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Capacity of the intensity-driven signal transduction channel with and without feedback 有反馈和无反馈时强度驱动信号转导通道的容量
IF 4.7 4区 计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-12-11 DOI: 10.1016/j.nancom.2025.100609
Wenxuan Hui , Pengfeng Hou , Xiufang Ren
In the biological world, signal transduction plays a crucial role in coordinating cellular activities, maintaining homeostasis, and responding to the environment. In this paper, we first introduce the channel modeling of the intensity-driven signal transduction. We then show how to obtain the independent and identically distributed capacity and the feedback capacity for the Channel-Rhodopsin-2 receptor. We reveal that the non-feedback capacity of this channel equals its feedback capacity. Moreover, we give the upper bound of the capacity and provide a general method to maximize the directed information rate to obtain the optimal input distribution. Finally, simulation results are presented to confirm our analysis.
在生物世界中,信号转导在协调细胞活动、维持体内平衡和对环境的反应中起着至关重要的作用。本文首先介绍了强度驱动信号转导的信道建模。然后,我们展示了如何获得通道-视紫红质-2受体的独立和相同分布的容量和反馈容量。我们发现该信道的非反馈容量等于它的反馈容量。此外,我们还给出了容量的上界,并给出了最大化有向信息率以获得最优输入分布的一般方法。最后给出了仿真结果来验证我们的分析。
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引用次数: 0
Cascaded asymmetrical triple-ring multibus system: Modelling and performance analysis 级联不对称三环多总线系统:建模和性能分析
IF 4.7 4区 计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-11-09 DOI: 10.1016/j.nancom.2025.100598
Anshu Mala, Sanjoy Mandal
This study introduces a novel micro-optical ring resonator (MORR) structure designed to enhance filtering efficiency and channel capacity in dense wavelength-division multiplexing (DWDM) systems. The proposed design integrates two asymmetrical triple-ring multibus systems, effectively cascading three asymmetric ring-based MORRs with multiple output ports (1 × 2) to form a (1 × 4) bus configuration. The performance of the proposed MORR structures is mathematically modelled using the delay line approach in the Z-domain, with frequency response characteristics analyzed in MATLAB. The system is further designed and simulated using OptiFDTD software, where directional coupler design and field distribution analysis are also conducted. The frequency response of the designed MORRs is analyzed using OptiFDTD software and cross-verified with MATLAB simulations. The computed FSR from both methods shows a strong correlation, indicating high accuracy. Additionally, OptiSystem 18 is employed to simulate the system using an eye diagram analyzer, ensuring a noise-free model. The results demonstrate a high-quality signal with a low bit error rate (BER) and a Q-factor exceeding 20 at each output bus. This cascading approach significantly enhances signal processing efficiency, reduces crosstalk, and increases the number of output channels, thereby boosting data capacity in communication networks.
介绍了一种新型的微光环形谐振器(MORR)结构,旨在提高密集波分复用(DWDM)系统的滤波效率和信道容量。所提出的设计集成了两个不对称三环多总线系统,有效地级联了三个具有多个输出端口(1 × 2)的基于非对称环的morr,形成一个(1 × 4)总线配置。采用z域延迟线方法对该结构的性能进行了数学建模,并在MATLAB中对其频响特性进行了分析。利用OptiFDTD软件对系统进行了进一步的设计和仿真,并进行了定向耦合器设计和场分布分析。利用OptiFDTD软件分析了所设计的morr的频率响应,并通过MATLAB仿真进行了交叉验证。两种方法计算得到的FSR相关性强,精度高。此外,OptiSystem 18采用眼图分析仪对系统进行仿真,确保模型无噪声。结果表明,在每个输出总线上具有低误码率(BER)和超过20的q因子的高质量信号。这种级联方法显著提高了信号处理效率,减少了串扰,增加了输出通道的数量,从而提高了通信网络中的数据容量。
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引用次数: 0
Enhancing subthreshold interconnect performance with log-normal distribution model: A study of CNT bundles and CuCNT composites 利用对数正态分布模型增强阈下互连性能:碳纳米管束和碳纳米管复合材料的研究
IF 4.7 4区 计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-10-17 DOI: 10.1016/j.nancom.2025.100597
Ritika Sharma, Mayank Kumar Rai, Rajesh Khanna
This paper presents a more accurate diameter-dependent model based on a Log-Normal (Log-N) distribution, addressing the limitations of previous normal distribution models that can produce unrealistic negative CNT diameters. The model aligns closely with experimental data, with only a 1.1 % deviation. The study explores the circuit parameters and the performance of CNT bundles and CuCNT composite interconnects specifically within the subthreshold regime, where ultra-low-power operation is essential. Design optimizations enhance the electrical performance of CNT bundle interconnects by taking into account the effects of dielectric surface roughness and structural defects. Results indicate that optimized CuCNT composites reduce average crosstalk delay by 79.36 % and 45.41 % on rough and smooth substrates, respectively. The study further examines the impact of CNT count and aspect ratio scaling, showing that both optimized CNT bundles and CuCNT composites significantly improve subthreshold performance metrics. The optimized CuCNT composite interconnect achieves superior crosstalk delay reduction, bandwidth, power delay product, and stability, making it ideal for future low-power VLSI applications.
本文提出了一个基于对数正态分布(Log-N)的更精确的直径相关模型,解决了以前正态分布模型可能产生不切实际的负碳纳米管直径的局限性。该模型与实验数据非常吻合,只有1.1%的偏差。该研究探索了电路参数和碳纳米管束和CuCNT复合互连的性能,特别是在亚阈值范围内,超低功耗运行是必不可少的。设计优化通过考虑介电表面粗糙度和结构缺陷的影响来提高碳纳米管束互连的电性能。结果表明,优化后的CuCNT复合材料在粗糙基片和光滑基片上的平均串扰延迟分别降低了79.36%和45.41%。该研究进一步研究了碳纳米管数量和纵横比缩放的影响,表明优化的碳纳米管束和碳纳米管复合材料都显著提高了亚阈值性能指标。优化后的CuCNT复合互连实现了卓越的串扰延迟降低、带宽、功率延迟产品和稳定性,使其成为未来低功耗VLSI应用的理想选择。
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引用次数: 0
Optimized quantum self-attention neural network for biomedical tongue colour image analysis disease diagnosis and classification in Internet of Things 优化量子自关注神经网络用于生物医学舌色图像分析、物联网疾病诊断与分类
IF 4.7 4区 计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-10-16 DOI: 10.1016/j.nancom.2025.100596
S.R. Preethi , P. Chinniah , P. Ezhilarasi , T.R. Vijaya Lakshmi
Tongue characteristics reflect health conditions. In the context of emerging IoT healthcare, automated tongue image analysis is essential for accurate disease classification and diagnosis. Existing challenges include imaging variations, preprocessing issues, poor multiclass accuracy, IoT integration challenges and security concerns. To overcome these complications, Biomedical Tongue Colour Image Analysis using Optimized Quantum Self-Attention Neural Network for Disease Diagnosis and Classification in Internet of Things (BM-TCIA-QS-ANN) is proposed. Here, the input images are taken from tongue image dataset and type 2 diabetes mellitus tongue dataset. The gathered input images are pre-processed using Maximum Correntropy Quaternion Kalman Filtering (MCQ-KF) is employed to decrease noise and enhance the image quality. After preprocessing, the images are fed into Synchro-Transient-Extracting Transform (STET) to extract geometric and texture features like smaller half distance, center distance, circle area, square area, triangle area, energy, entropy, contrast, and homogeneity. Then the extracted features are fed into Quantum Self-Attention Neural Network (QS-ANN) for classifying the tongue images as healthy, Erosive Gastritis (EG), Chronic Gastritis (CG), Nephrotic Syndrome (NS), Diabetes Mellitus (DM), Nephritis (NT), Gastritis Verrucosa (GV), and Coronary Heart disease (CH) in the tongue image dataset and diabetes and non-diabetes in the type 2 diabetes mellitus tongue database. To enhance accuracy, the Pelican Optimization Algorithm (POA) is utilized to optimize QS-ANN parameters, ensuring precise tongue colour image analysis disease classification. The proposed BM-TCIA-QS-ANN technique is implemented in Python. The BM-TCIA-QS-ANN method achieves superior performance with 99.42 % accuracy, 98.34 % precision, and 98.12 % recall, outperforming existing techniques such as TDM-SE-ResNet50-GD, TD-CTLNTI-DCNN, and TRTS-DenseNet-IC respectively.
舌头的特征反映了健康状况。在新兴的物联网医疗背景下,自动舌头图像分析对于准确的疾病分类和诊断至关重要。现有的挑战包括成像变化、预处理问题、多类精度差、物联网集成挑战和安全问题。为了克服这些问题,提出了一种基于优化量子自关注神经网络的生物医学舌色图像分析方法(BM-TCIA-QS-ANN)。在这里,输入图像分别取自舌图像数据集和2型糖尿病舌数据集。采集到的输入图像采用最大相关四元数卡尔曼滤波(MCQ-KF)进行预处理,以降低噪声,提高图像质量。经过预处理后,将图像送入同步瞬态提取变换(STET),提取较小的半距、中心距离、圆形面积、正方形面积、三角形面积、能量、熵、对比度、均匀性等几何和纹理特征。然后将提取的特征输入量子自关注神经网络(QS-ANN),将舌头图像分类为健康、糜烂性胃炎(EG)、慢性胃炎(CG)、肾病综合征(NS)、糖尿病(DM)、肾炎(NT)、疣状胃炎(GV)、冠心病(CH),以及2型糖尿病舌头数据库中的糖尿病和非糖尿病。为了提高准确率,利用鹈鹕优化算法(Pelican Optimization Algorithm, POA)对QS-ANN参数进行优化,确保舌色图像分析疾病的精确分类。提出的BM-TCIA-QS-ANN技术在Python中实现。BM-TCIA-QS-ANN方法的准确率为99.42%,精密度为98.34%,召回率为98.12%,优于现有的TDM-SE-ResNet50-GD、TD-CTLNTI-DCNN和TRTS-DenseNet-IC技术。
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引用次数: 0
A nano-scale quantum-dot multiplexer architecture for logic units in internet of things healthcare systems 一种用于物联网医疗系统中逻辑单元的纳米级量子点多路复用架构
IF 4.7 4区 计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-10-01 DOI: 10.1016/j.nancom.2025.100595
Nuriddin Safoev , Madjit Karimov , Seyed-Sajad Ahmadpour , Muhammad Zohaib , Komil Tashev , Suhaib Ahmed
The Internet of Things (IoT) is a propelling technological shift that enables seamless networking between billions of physical devices across healthcare sectors, agriculture, smart cities, and industrial production lines. By integrating embedded sensors, actuators, and communication modules, IoT systems can gather real-time data, leading to better operational decisions and improved efficiency in healthcare systems. The rapid growth of IoT devices creates three main operational challenges related to power usage, efficiency, and thermal management requirements. The demand for more efficient, compact, high-speed, and energy-efficient devices poses significant challenges for these systems. Traditional complementary metal-oxide-semiconductor (CMOS)-based architectures struggle to meet these demanding requirements, representing a major barrier to the development of reliable and scalable next-generation IoT systems. This research demonstrates Quantum-Dot Cellular Automata (QCA) nanotechnology as an alternative solution because it performs logical operations through electron positioning rather than conventional current flow. This paper proposes a modified version of a QCA-based multiplexer design (MUX) since digital logic systems require these signal routing elements for operation. The fundamental 2:1 MUX is established using QCA cell-interaction principles, and then 4:1 and 8:1 QCA MUXs are designed through hierarchical expansion. The suggested modified MUX devices operate on a compact scale with minimal cells to reduce the occupied area compared to current MUX designs. The research outcomes demonstrate that QCA circuits hold promising potential for creating energy-saving, powerful, and scalable computational platforms for future IoT healthcare systems.
物联网(IoT)是一项推动技术变革的技术,可实现医疗保健行业、农业、智慧城市和工业生产线上数十亿物理设备之间的无缝连接。通过集成嵌入式传感器、执行器和通信模块,物联网系统可以收集实时数据,从而实现更好的运营决策,提高医疗保健系统的效率。物联网设备的快速增长带来了与电力使用、效率和热管理要求相关的三大运营挑战。对更高效、紧凑、高速和节能设备的需求对这些系统提出了重大挑战。传统的基于互补金属氧化物半导体(CMOS)的架构难以满足这些苛刻的要求,这是开发可靠和可扩展的下一代物联网系统的主要障碍。这项研究证明量子点细胞自动机(QCA)纳米技术是一种替代解决方案,因为它通过电子定位而不是传统的电流来执行逻辑操作。由于数字逻辑系统需要这些信号路由元素来运行,因此本文提出了基于qca的多路复用器设计(MUX)的改进版本。利用QCA细胞相互作用原理建立基本的2:1 MUX,然后通过分层扩展设计4:1和8:1 QCA MUX。与目前的MUX设计相比,建议修改的MUX设备以最小的单元在紧凑的规模上运行,以减少占用的面积。研究结果表明,QCA电路在为未来的物联网医疗保健系统创建节能、强大和可扩展的计算平台方面具有很大的潜力。
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引用次数: 0
TRMAC: A time-reversal-based MAC protocol for wireless networks within computing packages TRMAC:一种基于时间反转的MAC协议,用于计算包内的无线网络
IF 4.7 4区 计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-09-16 DOI: 10.1016/j.nancom.2025.100593
Ama Bandara, Abhijit Das, Fátima Rodríguez-Galán, Eduard Alarcón, Sergi Abadal
As chiplet-based integration and many-core architectures become the norm in computing, on-chip wireless communication has emerged as a compelling alternative to traditional interconnects. However, scalable Medium Access Control (MAC) remains a fundamental challenge, particularly under dense traffic and limited spectral resources. This paper presents TRMAC, a novel cross-layer MAC protocol that exploits the spatial focusing capability of Time Reversal (TR) to enable multiple parallel transmissions over a shared frequency channel. By leveraging the quasi-deterministic nature of on-chip wireless channels, TRMAC pre-characterizes Channel Impulse Responses (CIRs) to coordinate access using energy-based thresholds, eliminating the need for orthogonal resource allocation or centralized arbitration. Through detailed physical-layer simulation and system-level evaluation on diverse traffic, TRMAC demonstrates comparable or superior performance to existing multi-channel MAC protocols, achieving low latency, high throughput, and strong scalability across hundreds of cores. Moreover, we prove that TRMAC can be utilized for parallel transmissions with a single frequency channel with a similar throughput and latency as in using multiple frequency bands, omitting the need for complex transceivers.
随着基于芯片的集成和多核架构成为计算领域的标准,片上无线通信已经成为传统互连的一个引人注目的替代方案。然而,可扩展的介质访问控制(MAC)仍然是一个根本性的挑战,特别是在密集的流量和有限的频谱资源下。TRMAC是一种新颖的跨层MAC协议,它利用时间反转(TR)的空间聚焦能力,在共享频率信道上实现多个并行传输。通过利用片上无线信道的准确定性特性,TRMAC预先表征了信道脉冲响应(CIRs),使用基于能量的阈值来协调访问,从而消除了正交资源分配或集中仲裁的需要。通过详细的物理层仿真和对不同流量的系统级评估,TRMAC表现出与现有多通道MAC协议相当或更好的性能,实现了低延迟、高吞吐量和跨数百核的强大可扩展性。此外,我们证明TRMAC可以用于单频通道的并行传输,其吞吐量和延迟与使用多个频段相似,从而无需复杂的收发器。
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引用次数: 0
Parity generator-checker based nano communication network using reversible quantum majority voter 基于奇偶生成器校验器的可逆量子多数投票人纳米通信网络
IF 4.7 4区 计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-09-10 DOI: 10.1016/j.nancom.2025.100594
Arpita Kundu , Jadav Chandra Das , Bikash Debnath , Debashis De
Quantum computing has emerged as a transformative paradigm with profound implications for computation, communication, encryption, and information theory. As classical systems approach their miniaturization and energy-efficiency limits, quantum technologies offer new mechanisms rooted in superposition, entanglement, and reversibility. This paper introduces a foundational nanocommunication framework that integrates three known reversible circuit primitives—majority voter, parity generator, and parity checker—into a unified communication system. Unlike prior works that analyze these circuits in isolation, the proposed architecture validates their combined functionality on the IBM Quantum platform, tested under both ideal (Aer simulator) and realistic noisy (NISQ hardware) conditions. By incorporating depolarizing noise models, mid-circuit resets, and hardware execution, the framework directly reflects the physical constraints of real devices, including qubit errors, decoherence, and relaxation effects. Simulation and hardware results demonstrate system-level fidelity, circuit cost, and accuracy for both small- and higher-bit counts. Comparative analysis with existing teleportation- and entanglement-based protocols highlights the efficiency and scalability of the approach. Overall, this study establishes a practical and foundational step toward noise-resilient, parity-based quantum communication systems, paving the way for larger processor-scale designs in the future.
量子计算已经成为一种革命性的范式,对计算、通信、加密和信息理论有着深远的影响。当经典系统接近其小型化和能效极限时,量子技术提供了基于叠加、纠缠和可逆性的新机制。本文介绍了一个基本的纳米通信框架,该框架集成了三种已知的可逆电路原语-多数投票人,奇偶校验器和奇偶校验器-到一个统一的通信系统中。与之前孤立分析这些电路的工作不同,所提出的架构在IBM量子平台上验证了它们的综合功能,并在理想(Aer模拟器)和现实噪声(NISQ硬件)条件下进行了测试。通过结合去极化噪声模型、中路复位和硬件执行,该框架直接反映了实际设备的物理约束,包括量子位误差、退相干和松弛效应。仿真和硬件结果证明了系统级保真度、电路成本和小比特数和高比特数的精度。与现有的基于隐形传态和纠缠的协议的比较分析突出了该方法的效率和可扩展性。总的来说,这项研究为抗噪声、基于奇偶的量子通信系统迈出了实用和基础的一步,为未来更大的处理器规模设计铺平了道路。
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引用次数: 0
DPOR: A data priority-based opportunity routing protocol for intra-body nanonetworks DPOR:基于数据优先级的体内纳米网络机会路由协议
IF 4.7 4区 计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-09-01 DOI: 10.1016/j.nancom.2025.100586
Yi-Wei Chen , Xin-Wei Yao , Qiang Li
The improvement of nanocommunication technology has promoted intra-body medical applications. With the advancement of nano-devices and terahertz communication technology, the performance of intra-body nanonetworks has been continuously enhanced, making the remote medical data transmission a reality. Intra-body nanonetworks can stably transmit the physiological information captured within the human body to the distant medical service center. Considering the aqueous environment of the human body, the communication of nanonetworks is subject to environmental interference and the physical limitations of nano-devices, and traditional routing protocols are difficult to meet the communication requirements in intra-body nanonetworks. Especially in the aspect of health monitoring,different types of data have corresponding importance, and some urgent data deserve more attention. For example, signals of acute arrhythmias (such as ventricular fibrillation) detected by nano-nodes are of the highest priority. Therefore, this paper designs a Data Priority-based Opportunistic Routing (DPOR) protocol. In this protocol, nano-nodes select the appropriate relay according to the level of data priority to improve the transmission efficiency of intra-body nanonetworks. On this basis, a thermal-aware model is constructed. By restricting the energy of nano-nodes and managing the energy consumption of nodes, it prevents nodes from overheating and damaging human tissues. Simulation experiments show that this model can optimize the routing selection, extend the network lifetime, and ensure the timeliness and reliability of transmission during the data transmission process while ensuring the safety of node temperature.
纳米通信技术的进步促进了体内医疗的应用。随着纳米器件和太赫兹通信技术的进步,体内纳米网络的性能不断增强,使远程医疗数据传输成为现实。体内纳米网络可以稳定地将人体内捕获的生理信息传输到远程医疗服务中心。考虑到人体的水环境,纳米网络的通信受到环境干扰和纳米器件的物理限制,传统的路由协议难以满足体内纳米网络的通信需求。特别是在健康监测方面,不同类型的数据有相应的重要性,一些紧急的数据更值得关注。例如,纳米节点检测到的急性心律失常(如心室颤动)信号是最优先考虑的。为此,本文设计了一种基于数据优先级的机会路由协议(DPOR)。在该协议中,纳米节点根据数据优先级的高低选择合适的中继,以提高体内纳米网络的传输效率。在此基础上,建立了热感知模型。通过限制纳米节点的能量和管理节点的能量消耗,它可以防止节点过热和损害人体组织。仿真实验表明,该模型可以优化路由选择,延长网络寿命,在数据传输过程中保证传输的及时性和可靠性,同时保证节点温度的安全性。
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引用次数: 0
Tunable THz sensing for early detection of skin cancer by deep learning enabled image reconstruction 通过深度学习实现图像重建,用于皮肤癌早期检测的可调谐太赫兹感应
IF 4.7 4区 计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-08-14 DOI: 10.1016/j.nancom.2025.100585
Priyanka Das, Ameer Abbas H, Sheena Christabel Pravin, Lekha P
This research reports deep learning model-based image reconstruction of healthy cells and cancerous cells by deployment of metamaterial absorbers. Two different tunable absorbers have been proposed. In absorber I, tunability is introduced by varying the chemical potential of graphene strips which act as switches while in absorber II, tunability is facilitated by using multiple graphene patches embedded in slotted silver patches. Equivalent circuit models (ECM) have been proposed for modelling the electromagnetic coupling between different constituents in the absorbers by lumped parameters for analysing the reflection characteristics. This study is vital for comprehending the effect of the absorber geometry in determining the resonant frequencies corresponding to peak absorption and reflection nulls. The surface current distribution aids in determining whether electric or magnetic resonances are formed in the absorber. The tunable absorbers achieved a maximum sensitivity of 435 GHz/RIU. Maximum quality factor of 319 and figure of merit (FOM) of 11 have been obtained. The proposed absorbers can be used in detecting cancerous cells of human skin when the latter is placed as an analyte over it. Distinct 2D images of healthy and cancerous cells have been reconstructed from the reflection characteristics of the absorber when placed in vicinity of human skin which ensures that it can be used as a biosensor for non-invasive detection of skin cancer at an early stage. A meticulous analysis of convolutional neural network (CNN) enabled imaging algorithm from the reflectance spectrum has been elucidated. The model achieved 94.3% accuracy, 92.7% sensitivity, 95.8% specificity, and an F1 score of 93.2%.
本研究报告了基于深度学习模型的图像重建健康细胞和癌细胞通过部署超材料吸收剂。提出了两种不同的可调谐吸收器。在吸收剂I中,通过改变充当开关的石墨烯条的化学势来引入可调性,而在吸收剂II中,通过在开槽银片中嵌入多个石墨烯片来促进可调性。提出了等效电路模型(ECM),利用集总参数来模拟吸收器中不同组分之间的电磁耦合,从而分析其反射特性。这项研究对于理解吸收器几何形状对确定峰值吸收和反射零值对应的共振频率的影响至关重要。表面电流分布有助于确定在吸收器中是否形成了电或磁共振。可调谐吸收器的最大灵敏度达到435 GHz/RIU。最大品质因子为319,最佳品质系数(FOM)为11。所提出的吸收剂可用于检测人体皮肤的癌细胞,当后者作为分析物放置在其上。当将吸收剂放置在人体皮肤附近时,根据其反射特性重建了健康细胞和癌细胞的不同二维图像,这确保了它可以用作生物传感器,用于在早期阶段对皮肤癌进行非侵入性检测。从反射光谱角度对卷积神经网络(CNN)成像算法进行了细致的分析。该模型准确率为94.3%,灵敏度为92.7%,特异性为95.8%,F1评分为93.2%。
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引用次数: 0
Using off-the-shelf biosensors to implement gateways for alarm-system nanonetworks 使用现成的生物传感器实现警报系统纳米网络的网关
IF 4.7 4区 计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-07-30 DOI: 10.1016/j.nancom.2025.100584
Florian Lau , Lara Josephine Prange , Regine Wendt , Sarah Scheer , Christian Hyttrek , Saswati Pal , Jorge Torres Gómez , Falko Dressler , Stefan Fischer
DNA-based nanonetworks hold great promise for future biomedical applications, especially in the areas of early disease detection and targeted therapy. However, reliably transmitting information from the nanoscale to external monitoring systems remains a major challenge. This paper explores using commercially available continuous glucose monitoring (CGM) sensors as gateways between in vivo nanonetworks and external devices. We propose a novel architecture in which DNA-based nanosensors release glucose as a signaling molecule when disease-relevant biomarkers are detected. CGM systems can detect these glucose surges, enabling real-time external communication. After analyzing various biosensor types, we found that CGM sensors are the most viable option due to their widespread availability, biocompatibility, and ability to measure biochemical signals. We present several architectural alternatives, calculate the required signal strength for reliable detection, and discuss potential experimental validation strategies. Our findings highlight a feasible and practical pathway toward integrating nanoscale diagnostics with existing biosensing technologies.
基于dna的纳米网络在未来的生物医学应用中有着巨大的前景,特别是在早期疾病检测和靶向治疗领域。然而,可靠地将信息从纳米尺度传输到外部监测系统仍然是一个主要挑战。本文探讨了使用商业上可用的连续葡萄糖监测(CGM)传感器作为体内纳米网络和外部设备之间的网关。我们提出了一种新的结构,当检测到与疾病相关的生物标志物时,基于dna的纳米传感器释放葡萄糖作为信号分子。CGM系统可以检测这些血糖激增,实现实时外部通信。在分析了各种类型的生物传感器后,我们发现CGM传感器是最可行的选择,因为它们具有广泛的可用性、生物相容性和测量生化信号的能力。我们提出了几种架构替代方案,计算了可靠检测所需的信号强度,并讨论了潜在的实验验证策略。我们的发现强调了将纳米级诊断与现有生物传感技术相结合的可行和实用途径。
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引用次数: 0
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