Background
Nanoscale investigations with ordinary optical microscopes require evanescent fields resolution when the target is to go beyond the λ/2 resolution limit. Photon-phonon interactions from quantum mechanics to Newtonian mechanics, explain how traditional microscopy can achieve nanometric accuracy in Experimental Mechanics.
Objectives
To detail NanoFraction (NF), a digital system that works beyond the limits of traditional optical microscopy.
Methods
The NF system is an extension of more than two decades of research work by the authors in super-resolution. NF overcomes the λ/2 resolution limit by recording the near-field in the far-field, enabling broader fields of view with unmatched spatial resolution. NF uses lasers with wavelengths between 400 and 700 nm to capture images of objects in the nanometer range. Unlike fluorescent super-resolution or cryogenic electron microscopy, NF is a label-free imaging modality. Artificial intelligence (AI) is integral to the NF system.
Results
The NF system is successfully utilized for nanoscale investigations in chemistry, semi-conductor industry and living organisms such as (i) detection of crystalline structures (i.e. NaCl nano-crystals); (ii) detection of defects in diamond wafers; (iii) detection of COVID-19 virus structures. The article demonstrates how the NF system can be applied to organic materials, such as the COVID-19 virus.
Conclusions
NF allows to visualize details that were previously only visible with transmission electron microscopy (TEM), but without the limitations of this technique. The NF system has important implications for understanding the nanoworld.
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