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2007 IEEE 20th International Conference on Micro Electro Mechanical Systems (MEMS)最新文献

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gold-nanoparticle-enhanced IGG immunological detection by in-situ fabry-perot sensor 金纳米颗粒增强IGG免疫检测的原位法布里-珀罗传感器
Pub Date : 2007-01-01 DOI: 10.1109/MEMSYS.2007.4432985
Y. Tseng, Shu-Ting Jhuang, Chung-Shi Yang, F. Tseng
This paper proposes a needle-type biosensor for immunological application, which combines the abilities of real-time monitoring, in-situ measurement and high sensitivity, by adopting gold-nanoparticles (GNPs) coated with antibody to enhance the signal of Fabry-Perot (F-P) interferometry in an optic fiber sensing system. Strong reflection induced by larger index mismatch and longer optical path from GNPs-protein conjugation are suggested to attribute most to the signal enhancement in F-P interference shift. The experiments carry out the monitoring of immuno-sensing in real-time by the employment of rabbit IgG conjugate to GNPs-anti-rabbit IgG And the detection limit was demonstrated to approach 0.17 nM (-25.5 ng/ml), which was three orders of magnitude better than those of the traditional fiber-based F-P biosensors. Besides, the reproducibility of the sensor has been tested through at least three cycles of detection/surface-regeneration process and demonstrated a reasonable consistency. The relationship between the concentrations of GNPs-antibody and F-P spectrum shift has also been characterized. The time-constant of this sensor to complete one cycle of biomolecule-detection and surface-regeneration can be as low as 4 minutes.
本文提出了一种结合实时监测、原位测量和高灵敏度的针刺型免疫传感器,该传感器采用包被抗体的金纳米粒子(GNPs)增强光纤传感系统中F-P干涉测量的信号。gnps -蛋白偶联引起的较大的折射率失配和较长的光程引起的强反射是F-P干涉位移中信号增强的主要原因。实验采用兔IgG偶联gnps -抗兔IgG对免疫传感进行实时监测,检测限接近0.17 nM (-25.5 ng/ml),比传统纤维基F-P生物传感器提高了3个数量级。此外,传感器的再现性已经通过至少三个周期的检测/表面再生过程进行了测试,并证明了合理的一致性。研究了gnps抗体浓度与F-P谱移之间的关系。该传感器完成一个生物分子检测和表面再生周期的时间常数可低至4分钟。
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引用次数: 1
Impact of miniaturization on the current handling of electrostatic MEMS resonators 微型化对静电MEMS谐振器电流处理的影响
Pub Date : 2007-01-01 DOI: 10.1109/MEMSYS.2007.4433092
M. Agarwal, H. Mehta, R. Candler, S. Chandorkar, Bongsang Kim, M. Hopcroft, R. Melamud, G. Bahl, G. Yama, T. Kenny, B. Murmann
This paper studies the scaling of nonlinearities with miniaturization in double-ended-tuning-fork (DETF) MEMS resonators. We find that the increase in resonant frequency associated with beam length reduction strongly improves current handling; e.g. shortening the beams by a factor of 5 results in a 100- fold increase in sustainable signal current. Using the nonlinear models and scaling observed in this work, we present considerations for optimization of the resonant structure design and the electrostatic gap size.
本文研究了双端音叉(DETF) MEMS谐振器中非线性的微型化问题。我们发现,随着波束长度的减小,谐振频率的增加大大改善了电流处理;例如,将波束缩短5倍,可使持续信号电流增加100倍。利用本工作中观察到的非线性模型和尺度,我们提出了优化谐振结构设计和静电间隙尺寸的考虑。
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引用次数: 7
Pyrolyzed parylene structure as selective emittter for high-efficiency thermophotovoltaic power generation 热解聚对二甲苯结构作为高效热光伏发电的选择性发射体
Pub Date : 2007-01-01 DOI: 10.1109/MEMSYS.2007.4433137
D. Takagi, Y. Suzuki, N. Kasagi
In this report, we propose Si microcavities coated with parylene-pyrolyzed carbon as a selective emitter for high-efficiency thermophotovoltaic (TPV) power generation system. In order to obtain carbon films with uniform thickness on three-dimensional Si structures, we adopt CxFy deposition on the top of the parylene film before the pyrolysis. The carbon yield doubles with the CxFy deposition. We also demonstrate that the Si microcavities coated with carbon thus fabricated exhibit an emittance peak near the wavelength of 2.6 mum, which corresponds to the characteristic electromagnetic mode of the cavity.
在本报告中,我们提出了一种涂有二甲苯热解碳的硅微腔作为高效热光伏(TPV)发电系统的选择性发射器。为了在三维Si结构上获得厚度均匀的碳膜,我们在热解前在聚对二甲苯膜的顶部采用了CxFy沉积。碳产率随CxFy沉积而增加一倍。我们还证明了用这种方法制备的碳包覆的硅微腔在2.6 μ m波长附近有一个发射峰,这与腔的特征电磁模式相对应。
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引用次数: 1
Two approaches to micromachining si heat exchanger for Joule-Thomson cryosurgical probes 焦耳-汤姆逊冷冻探针硅热交换器微加工的两种方法
Pub Date : 2007-01-01 DOI: 10.1109/MEMSYS.2007.4433062
Weibin Zhu, M. White, D. W. Hoch, G. Nellis, S. Klein, Y. Gianchandani
This paper describes results from two types of micromachined recuperative heat exchangers intended for Joule-Thomson (J-T) cryosurgical probes, which require high stream-to-stream thermal conductance while restricting parasitic stream-wise (axial) conduction. In design A, rows of fins composed of high conductivity silicon are bonded onto a 100 mum thick base plate composed of low conductivity Pyrex glass. This planar device has a footprint of 6times1.5 cm2 and 2.5 mm thickness, and is fabricated using a 5-mask process. In design B, numerous high-conductivity silicon plates alternating with low-conductivity Pyrex spacers are stacked together. This has a footprint of 1times1cm2, a length of 1.4 cm, and is fabricated using a 3-mask process. Preliminary experiments show that the primary performance constraint for design A is imposed by the compromise between mechanical robustness and transverse conductance of the thin glass base plate that separates the high pressure and low pressure streams. Design B enhances the robustness of the device and can sustain higher pressure.
本文描述了用于焦耳-汤姆逊(J-T)冷冻探针的两种类型的微机械回热式热交换器的结果,这两种类型的热交换器需要高流到流的导热性,同时限制寄生流方向(轴向)传导。在设计A中,一排排由高导电性硅组成的鳍片粘合在100毫米厚的由低导电性耐热玻璃组成的底板上。该平面器件的占地面积为6倍1.5 cm2,厚度为2.5 mm,采用5掩模工艺制造。在设计B中,大量的高导电性硅片与低导电性的耐热玻璃间隔片交替堆叠在一起。它的占地面积为1乘以1平方厘米,长度为1.4厘米,并使用3掩模工艺制造。初步实验表明,设计A的主要性能约束是在分离高压流和低压流的薄玻璃基板的机械稳健性和横向电导之间的折衷。设计B增强了装置的坚固性,可以承受更高的压力。
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引用次数: 7
Unidirectional motion of microtubules and microspheres by Dynein motor protein 动力蛋白驱动微管和微球的单向运动
Pub Date : 2007-01-01 DOI: 10.1109/MEMSYS.2007.4433074
T. Murakami, T. Sugie, T. Kon, R. Yokokawa
This paper reports a nanotransport system with the directional movement control. The system consists of motor proteins, dynein and kinesin, and their tracks, microtubules. Dynein molecules are specifically immobilized on a microchannel glass surface and fluorescently labeled microtubules were transported by dynein motion. Moving directions of gliding microtubules were controlled by a pressure-driven flow through the microchannel, and their polarities were oriented in the designated direction. We have also examined their polarities by the unidirectional transport of kinesin-coated microspheres. Orientation ratios of microtubules were evaluated as 90.9% and 78.8% by moving microtubules and microspheres, respectively. Integrating dynein and kinesin provides a possibility to compose a two-dimensional nanotransport system.
本文报道了一种具有定向运动控制的纳米输运系统。该系统由运动蛋白、动力蛋白和动力蛋白以及它们的轨迹微管组成。动力蛋白分子被固定在微通道玻璃表面,荧光标记的微管通过动力蛋白运动进行运输。滑动微管的运动方向由通过微通道的压力驱动流控制,其极性在指定方向上取向。我们还通过动力蛋白包被的微球的单向输运检验了它们的极性。微管和微球的取向率分别为90.9%和78.8%。整合动力蛋白和动力蛋白提供了组成二维纳米输运系统的可能性。
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引用次数: 1
Localized back-side heating for low-temperature wafer-level bonding 局部背面加热,用于低温晶圆级粘合
Pub Date : 2007-01-01 DOI: 10.1109/MEMSYS.2007.4433146
J. Mitchell, K. Najafi
A new wafer-level method has been developed for localized heating of the bond region between two wafers. Using this method, one of the two wafers to be bonded is heated from the backside, and the other is cooled from the backside, so that heat flows through the bond regions while the device regions stay relatively cool. In this work, integrated temperature sensors were used to measure the temperature at different distances from the bond region during Si to glass and Si to Si (with a -7 mum SiO2) bonds in order to verify the utility of this bonding technique. The temperature was measured to be only 25% and 37% of the bond ring temperature at 650 mum away from the bond ring for a Si to glass bond and 250 mum away from the bond ring for a Si to Si (with a ~7 mum oxide) bond respectively for bond ring temperatures up to 410degC and 200degC. Furthermore a successful Au-Si eutectic bond was demonstrated using this technique.
本文提出了一种新的晶圆级方法,用于对两个晶圆之间的键合区域进行局部加热。使用这种方法,两个晶圆中的一个从背面加热,另一个从背面冷却,这样热量流过键合区域,而器件区域保持相对凉爽。在这项工作中,为了验证这种键合技术的实用性,使用集成温度传感器测量了Si到玻璃和Si到Si(含-7 mum SiO2)键合过程中距离键合区域不同距离的温度。当键环温度高达410℃和200℃时,在距离硅-玻璃键环650℃和距离Si - Si键环250℃时,测得的温度分别为键环温度的25%和37%。此外,利用该技术成功地证明了金硅共晶键。
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引用次数: 1
A high-resolution amperometric acetylcholine biosensor based on nano self-assembly of carbon nanotubes 基于碳纳米管纳米自组装的高分辨率乙酰胆碱生物传感器
Pub Date : 2007-01-01 DOI: 10.1109/MEMSYS.2007.4433151
W. Xue, T. Cui
We present a carbon nanotube thin film based device as a high-resolution acetylcholine sensor. Carbon nanotube and acetylcholinesterase thin films are self-assembled on a silicon substrate as conducting and sensing layers, respectively. Both films are deposited using layer-by-layer self-assembly process. The conductance of the carbon nanotube film is changed due to the generated hydrogen ions in the acetylcholine solution. The resolution of the device is measured as 100 pM. Due to its high resolution, small size, and low cost, the carbon nanotube biosensor has tremendous potential for applications to medical research and clinical diagnosis.
我们提出了一种基于碳纳米管薄膜的器件作为高分辨率乙酰胆碱传感器。碳纳米管薄膜和乙酰胆碱酯酶薄膜分别在硅衬底上自组装为导电层和传感层。这两种薄膜都是用一层一层的自组装工艺沉积的。乙酰胆碱溶液中产生的氢离子改变了碳纳米管薄膜的电导。该装置的分辨率测量为100pm。碳纳米管生物传感器具有分辨率高、体积小、成本低等特点,在医学研究和临床诊断方面具有巨大的应用潜力。
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引用次数: 4
Development of high-resolution intraluminal and intravascular MRI probe using microfabrication on cylindrical substrates 高分辨率腔内和血管内MRI探针在圆柱形基板上的微加工
Pub Date : 2007-01-01 DOI: 10.1109/MEMSYS.2007.4433065
S. Goto, T. Matsunaga, Y. Matsuoka, K. Kuroda, M. Esashi, Y. Haga
The objective of this study is development of high-resolution intraluminal and intravascular MRI probe using microfabrication on cylindrical substrates. MRI holds promise for in vivo characterization due to its potential for obtaining high-resolution images and its sensitivity to the compositional characteristics of lesion. By placing a receive coil in the human body, NMR signals from the tissue surrounding the coil can be detected sensitively and the method enables in vivo high-resolution imaging (high spatial resolution and high spectroscopic resolution). The preferable receive coil has homogeneous RF receptivity around the probe and high-SNR. Novel coil designs and/or multi-coil have capabilities to meet these demands. To connect the tuning/matching circuit and amplifier circuit near the coil is needed to improve SNR of the system. Microfabrication on cylindrical substrate is one of methods for fabricating arbitrary coil pattern and the tuning/matching circuit on the tube with small diameters. Using a maskless lithography technique, solenoid coil, tilted coil and saddle shaped coil have been fabricated on glass tube with 2 mm O.D.. Imaging test of the coils were performed on 3 T MRI in a 2% agar phantom.
本研究的目的是开发高分辨率腔内和血管内MRI探针,在圆柱形衬底上使用微加工。由于MRI具有获得高分辨率图像的潜力以及对病变成分特征的敏感性,因此它有望用于体内表征。通过在人体中放置一个接收线圈,可以灵敏地检测到来自线圈周围组织的核磁共振信号,并且该方法可以实现体内高分辨率成像(高空间分辨率和高光谱分辨率)。优选的接收线圈在探头周围具有均匀的射频接受度和高信噪比。新颖的线圈设计和/或多线圈有能力满足这些要求。为了提高系统的信噪比,需要在线圈附近连接调谐/匹配电路和放大电路。圆柱基板微加工是在小直径管上制作任意线圈图案和调谐/匹配电路的方法之一。采用无掩模光刻技术,电磁线圈,倾斜线圈和鞍形线圈已制作在玻璃管与2mm外径。在3t MRI上对线圈进行2%琼脂幻影成像测试。
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引用次数: 19
Nanoelectromechanical systems: Potential, progress, & projections 纳米机电系统:潜力、进展与展望
Pub Date : 2007-01-01 DOI: 10.1109/MEMSYS.2007.4433022
M. Roukes
Nanoelectromechanical systems (NEMS) represent the next regime of size reduction beyond the microscale for mechanical devices. In their tiniest, ultimate realization, NEMS will be formed with sub-nanometer scale precision from atomic- and molecular-scale mechanical elements as first envisaged by Feynman (1). Although nanowire and nanotube based NEMS today verge on this domain, their assembly into functional devices remains more of an art than a science, as they are typically fabricated one-by-one by complicated means with low yield. By contrast, the most robust forms of NEMS are currently patterned by top-down methods; in fact their production is now being scaled to enable large-scale integration over 200 mm wafers with minimum feature sizes that are below 50 nm. In this paper I will describe how nanoscale mechanical elements provide benefits beyond the obvious, that is, benefits in addition to the possibility of increased device density. The reduced size of NEMS enables mechanical functionality that completely transcends what is possible at the microscale with MEMS (2). However, size reduction to the nanoscale may not be a panacea for all applications - for some applications larger may still be better!
纳米机电系统(NEMS)代表了机械设备在微观尺度之外的下一个尺寸减小机制。在最小的、最终的实现中,NEMS将以亚纳米尺度的精度由Feynman首先设想的原子和分子尺度的机械元件形成(1)。尽管基于纳米线和纳米管的NEMS今天接近于这个领域,但将它们组装成功能器件仍然是一门艺术,而不是一门科学,因为它们通常是通过复杂的方法一个接一个地制造,产量很低。相比之下,目前最强大的NEMS形式是由自上而下的方法形成的;事实上,他们的生产现在正在扩大规模,以实现200毫米以上晶圆的大规模集成,最小特征尺寸低于50纳米。在本文中,我将描述纳米级机械元件如何提供超越显而易见的好处,即除了增加器件密度的可能性之外的好处。NEMS的缩小尺寸使机械功能完全超越了MEMS在微尺度上的可能性(2)。然而,尺寸缩小到纳米尺度可能不是所有应用的灵丹妙药-对于某些应用来说,更大的可能仍然更好!
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引用次数: 2
Microprobe microsystem platform inserted during early metamorphosis to actuate insect flight muscle 微探针微系统平台插入在早期变态,以驱动昆虫飞行肌肉
Pub Date : 2007-01-01 DOI: 10.1109/MEMSYS.2007.4432976
A. Bozkurt, A. Paul, S. Pulla, A. Ramkumar, B. Blossey, J. Ewer, R. Gilmour, A. Lal
Following from early work demonstrating that early pupal- stage inserts are accepted by insects [9], a microprobe based microsystem platform was designed with respect to the position of the muscle bundles, and was inserted into the thorax at 4 days of the pupal stage. The platform is roughly 8times7times1.5 mm3 in size with probe thickness of 200 mum and weighs 500 mg, which the moth is able to successfully carry in the adult stage. In addition to the microsystem, an anchor to easily manipulate the adults was successfully formed in the insect by placing a glass-capillary through the pupae. The pupae emerged successfully, and the microsystem was used to characterize the potential for flight control. As part of the work to determine the microplatform design, we determined the strength-interval profiles of the pulses needed for direct muscle actuation. Two sets of flight muscles, which are symmetrically present on either side of the thorax, were differentially electrically actuated, which potentially influences the individual wing beat frequency and amplitude resulting in controlled turning behavior during flight.
根据早期的研究表明昆虫可以接受早期的蛹期插入物[9],我们根据肌束的位置设计了一个基于微探针的微系统平台,并在蛹期第4天将其插入胸腔。该平台的大小约为8 × 7 × 1.5毫米,探针厚度为200毫米,重量为500毫克,蛾子能够在成虫阶段成功携带。除了微系统外,通过在蛹中放置玻璃毛细管,成功地在昆虫体内形成了一个易于操纵成虫的锚。蛹成功出现,微系统被用来表征飞行控制的潜力。作为确定微平台设计工作的一部分,我们确定了直接肌肉驱动所需脉冲的强度间隔分布。两组飞行肌肉对称地分布在胸部两侧,是不同的电动驱动,这可能会影响单个翅膀拍打的频率和幅度,从而在飞行过程中控制转弯行为。
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引用次数: 31
期刊
2007 IEEE 20th International Conference on Micro Electro Mechanical Systems (MEMS)
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