Pub Date : 2024-08-01DOI: 10.1007/s13738-024-03061-3
Ayse Tan, Samir Abbas Ali Noma
In the present study, some hybrid compounds containing 1,2,3-triazole and naphthalene subunits 16(a–g) and 17(a–f) were synthesized and characterized by 1H, 13C-NMR, FT-IR, and HR-MS analyses. The in vitro inhibitor activities on the xanthine oxidase (XO) enzyme of all the target compounds were investigated and compared with allopurinol, which is one of the most common gout drugs and inhibits the XO. The activity results show that all the target compounds have potential XO inhibitor activities. The compounds showed IC50 values in the range of 0.825–2.254 μM on the XO. IC50 value of allopurinol on the XO was determined to be 1.475 μM. 16e and 17e compounds among them exhibited the best inhibitions compared to other compounds and allopurinol. Additionally, molecular docking studies were carried out on the 3D crystallographic structure of the XO to investigate possible interactions with the active site of the XO of all compounds. According to the docking results, all the target compounds showed that the best binding energies vary in the between − 9.71 kcal.mol−1 and − 11.43 kcal.mol−1. Finally, in silico ADME and toxicity properties of the compounds were investigated using the Swiss ADME, ProTox-II, and Osiris Property Explorer websites and it has been predicted that the target compounds have low toxicity profiles. Consequently, the compounds can be considered new promising inhibitors for the XO.
本研究合成了一些含有 1,2,3-三唑和萘亚基 16(a-g) 和 17(a-f) 的杂化化合物,并通过 1H、13C-NMR、FT-IR 和 HR-MS 分析对其进行了表征。研究了所有目标化合物对黄嘌呤氧化酶(XO)的体外抑制活性,并与别嘌醇进行了比较。活性结果表明,所有目标化合物都具有潜在的 XO 抑制活性。这些化合物对 XO 的 IC50 值在 0.825-2.254 μM 之间。别嘌醇对 XO 的 IC50 值为 1.475 μM。与其他化合物和别嘌醇相比,16e 和 17e 化合物的抑制效果最好。此外,还对 XO 的三维晶体结构进行了分子对接研究,以探讨所有化合物与 XO 活性位点之间可能存在的相互作用。根据对接结果,所有目标化合物的最佳结合能介于 - 9.71 kcal.mol-1 和 - 11.43 kcal.mol-1 之间。最后,利用 Swiss ADME、ProTox-II 和 Osiris Property Explorer 网站对化合物的 ADME 和毒性特性进行了研究,结果表明目标化合物具有低毒性。因此,这些化合物可被视为新的有前途的 XO 抑制剂。
{"title":"Novel hybrid compounds containing 1,2,3-triazole and naphthalene subunits as xanthine oxidase inhibitors","authors":"Ayse Tan, Samir Abbas Ali Noma","doi":"10.1007/s13738-024-03061-3","DOIUrl":"10.1007/s13738-024-03061-3","url":null,"abstract":"<div><p>In the present study, some hybrid compounds containing 1,2,3-triazole and naphthalene subunits <b>16</b>(<b>a</b>–<b>g</b>) and <b>17</b>(<b>a</b>–<b>f</b>) were synthesized and characterized by <sup>1</sup>H, <sup>13</sup>C-NMR, FT-IR, and HR-MS analyses. The in vitro inhibitor activities on the xanthine oxidase (XO) enzyme of all the target compounds were investigated and compared with allopurinol, which is one of the most common gout drugs and inhibits the XO. The activity results show that all the target compounds have potential XO inhibitor activities. The compounds showed IC<sub>50</sub> values in the range of 0.825–2.254 μM on the XO. IC<sub>50</sub> value of allopurinol on the XO was determined to be 1.475 μM. <b>16e</b> and <b>17e</b> compounds among them exhibited the best inhibitions compared to other compounds and allopurinol. Additionally, molecular docking studies were carried out on the 3D crystallographic structure of the XO to investigate possible interactions with the active site of the XO of all compounds. According to the docking results, all the target compounds showed that the best binding energies vary in the between − 9.71 kcal.mol<sup>−1</sup> and − 11.43 kcal.mol<sup>−1</sup>. Finally, in silico ADME and toxicity properties of the compounds were investigated using the Swiss ADME, ProTox-II, and Osiris Property Explorer websites and it has been predicted that the target compounds have low toxicity profiles. Consequently, the compounds can be considered new promising inhibitors for the XO.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 8","pages":"2249 - 2258"},"PeriodicalIF":2.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141871284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-30DOI: 10.1007/s13738-024-03054-2
A. Chaa, A. Haddad, G. Rekhila, S. Tria, M. Trari
The semiconducting properties of Mn3O4 thin films were assessed for the heterogeneous photocatalytic oxidation of Rhodamine B (Rh B). The films were grown on Al-substrate using a spray coating, and their physical and photoelectrochemical characteristics were studied. X-ray diffraction analysis showed a well-crystallized structure of the spinel Mn3O4. The atomic force microscopy revealed dense and irregular grains with a mean size of ~ 50 nm and a thickness of ~ 1 µm. The direct optical transition at 2.19 eV, in agreement with the brown color, is assigned to d–d transitions within the incomplete Mn-3d shell, which enables efficient photocatalytic conversion of the solar radiation. The photoelectrochemical measurements demonstrated p-type comportment, evidenced by a negative slope in the [capacitance−2–potential: C−2–E] graph with a flat band potential of + 0.35 VSCE and a hole density of 6.5 × 1018 cm−3. The electrochemical impedance spectroscopy (EIS) plot showed a semicircle due to a capacitive comportment of the bulk spinel (Rb = 70 kΩ cm2). The center positioned below the abscissa axis (− 23°) with a constant phase element (CPE). The conduction band (− 1.64 VSCE) is more cathodic than the ({text{O}}_{{2}} /{text{O}}_{{2}}^{ bullet - }) level, thus catalyzing the photocatalytic process by ({text{O}}_{{2}}^{ bullet - }) radicals. Under sunlight, 50% reduction of the Rh B concentration (10 ppm) was achieved within 1 h, the color removal, followed by spectrophotometry obeys a pseudo-first-order kinetic model with a rate constant of 9.9 × 10–3 min−1 (t1/2 = 70 min).
{"title":"Preparation of Mn3O4 nanoparticles on Al-substrate for degradation of Rhodamine B under solar light","authors":"A. Chaa, A. Haddad, G. Rekhila, S. Tria, M. Trari","doi":"10.1007/s13738-024-03054-2","DOIUrl":"10.1007/s13738-024-03054-2","url":null,"abstract":"<div><p>The semiconducting properties of Mn<sub>3</sub>O<sub>4</sub> thin films were assessed for the heterogeneous photocatalytic oxidation of Rhodamine B (Rh B). The films were grown on Al-substrate using a spray coating, and their physical and photoelectrochemical characteristics were studied. X-ray diffraction analysis showed a well-crystallized structure of the spinel Mn<sub>3</sub>O<sub>4</sub>. The atomic force microscopy revealed dense and irregular grains with a mean size of ~ 50 nm and a thickness of ~ 1 µm. The direct optical transition at 2.19 eV, in agreement with the brown color, is assigned to <i>d–d</i> transitions within the incomplete Mn-3<i>d</i> shell, which enables efficient photocatalytic conversion of the solar radiation. The photoelectrochemical measurements demonstrated <i>p</i>-type comportment, evidenced by a negative slope in the [capacitance<sup>−2</sup>–potential: C<sup>−2</sup>–E] graph with a flat band potential of + 0.35 <i>V</i><sub>SCE</sub> and a hole density of 6.5 × 10<sup>18</sup> cm<sup>−3</sup>. The electrochemical impedance spectroscopy (EIS) plot showed a semicircle due to a capacitive comportment of the bulk spinel (<i>R</i><sub><i>b</i></sub> = 70 kΩ cm<sup>2</sup>). The center positioned below the abscissa axis (− 23°) with a constant phase element (CPE). The conduction band (− 1.64 <i>V</i><sub>SCE</sub>) is more cathodic than the <span>({text{O}}_{{2}} /{text{O}}_{{2}}^{ bullet - })</span> level, thus catalyzing the photocatalytic process by <span>({text{O}}_{{2}}^{ bullet - })</span> radicals. Under sunlight, 50% reduction of the Rh B concentration (10 ppm) was achieved within 1 h, the color removal, followed by spectrophotometry obeys a pseudo-first-order kinetic model with a rate constant of 9.9 × 10<sup>–3</sup> min<sup>−1</sup> (<i>t</i><sub>1/2</sub> = 70 min).</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 8","pages":"2113 - 2120"},"PeriodicalIF":2.2,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13738-024-03054-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141871285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Copper oxide nanoparticles calcined at temperatures varying from 500 to 900 °C were prepared through non-aqueous sol–gel route by using 2-ethyl hexanol as a modifying agent. Phase composition, presence of functional groups, thermal behavior, surface morphology and elemental composition of the prepared samples were identified by XRD, IR, TGA, FESEM and EDX. The results revealed the formation of single phase, i.e., monoclinic tenorite copper oxide with its entire transformation after calcination at 500 °C. Polyhedron shape nanoparticles of size below 100 nm were formed with a significant increase in the particle size and agglomeration due to nucleation growth of nanoparticles with the rise in calcination temperature. The synthesized samples showed a direct band gap of 4.08–4.14 eV. The study revealed that following the non-aqueous sol–gel process with 2-ethyl hexanol as a modifying agent inhibited agglomeration resulting in the formation of well-dispersed nanoparticles.
{"title":"Synthesis and characterization of nanosize copper oxide by non-aqueous sol–gel process","authors":"Samreen Zahra, Tania Abbas, Asma Sheikh, Hamim Bukhari, Sarwat Zahra","doi":"10.1007/s13738-024-03065-z","DOIUrl":"10.1007/s13738-024-03065-z","url":null,"abstract":"<div><p>Copper oxide nanoparticles calcined at temperatures varying from 500 to 900 °C were prepared through non-aqueous sol–gel route by using 2-ethyl hexanol as a modifying agent. Phase composition, presence of functional groups, thermal behavior, surface morphology and elemental composition of the prepared samples were identified by XRD, IR, TGA, FESEM and EDX. The results revealed the formation of single phase, i.e., monoclinic tenorite copper oxide with its entire transformation after calcination at 500 °C. Polyhedron shape nanoparticles of size below 100 nm were formed with a significant increase in the particle size and agglomeration due to nucleation growth of nanoparticles with the rise in calcination temperature. The synthesized samples showed a direct band gap of 4.08–4.14 eV. The study revealed that following the non-aqueous sol–gel process with 2-ethyl hexanol as a modifying agent inhibited agglomeration resulting in the formation of well-dispersed nanoparticles.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 8","pages":"2211 - 2220"},"PeriodicalIF":2.2,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Current antidiabetic medications have a plethora of harmful side effects, and most of the drugs do not contain 1,3,4-oxadiazole moiety. Therefore, research into the development of novel drugs which contain 1,3,4-oxadiazole moiety with fewer side effects is necessary. Novel fluorine-incorporated 1,3,4-oxadiazole derivatives (1c–1n) were synthesized, characterized, and evaluated for α-amylase and α-glucosidase enzyme inhibitor activity. An in vivo Drosophila melanogaster model and an in vitro system were used to investigate its antidiabetic properties, further, which were characterized by 1HNMR, MASS, and FT-IR. Spectroscopic techniques and DFT are used to calculate more geometrically optimized molecule structures using the B3LYP technique. The compounds were tested against the α-glucosidase and α-amylase enzymes. Among different compounds tested, compounds 1i (IC50 = 54.83 µg/ml), 1k (IC50 = 64.95 µg/ml), 1m (IC50 = 64.78 µg/ml), and 1n (IC50 = 66.30 µg/ml) showed significant α-amylase inhibitor efficacy compared to the acarbose (IC50 = 35.17 µg/ml); compounds 1m (IC50 = 74.64 µg/ml) and 1i (IC50 = 60.35 µg/ml) exhibited significant α-glucosidase inhibitory action compared to acarbose (IC50 = 46.06 µg/ml). The docking study exhibited that compound 1i creates six hydrogen bonds and compound 1m forms three hydrogen bonding contacts at the active site of the enzyme (PDBID:4w93). The obtained results are demonstrated that compounds 1i, 1m, 1n, and 1k had greater antidiabetic activities and can be further taken into consideration for antidiabetic therapeutic interventions.
{"title":"Synthesis of novel oxadiazole derivatives: DFT calculations, molecular docking studies, and in vitro, in vivo evaluation of antidiabetic activity using Drosophila melanogaster model","authors":"Govinda Anjanayya, Ramesh Gani, Avinash Kudva, Shrinivas Joshi, Murigendra Hiremath, Apsara Kavital, Karabasanagouda Timanagouda, Basavarajaiah Mathada, Mohammad Javeed, Raifa Aziz, Shamprasad Raghu","doi":"10.1007/s13738-024-03067-x","DOIUrl":"10.1007/s13738-024-03067-x","url":null,"abstract":"<div><p>Current antidiabetic medications have a plethora of harmful side effects, and most of the drugs do not contain 1,3,4-oxadiazole moiety. Therefore, research into the development of novel drugs which contain 1,3,4-oxadiazole moiety with fewer side effects is necessary. Novel fluorine-incorporated 1,3,4-oxadiazole derivatives <b>(1c–1n)</b> were synthesized, characterized, and evaluated for <i>α</i>-amylase and <i>α</i>-glucosidase enzyme inhibitor activity. An in vivo <i>Drosophila melanogaster</i> model and an in vitro system were used to investigate its antidiabetic properties, further, which were characterized by <sup>1</sup>HNMR, MASS, and FT-IR. Spectroscopic techniques and DFT are used to calculate more geometrically optimized molecule structures using the B3LYP technique. The compounds were tested against the <i>α</i>-glucosidase and <i>α</i>-amylase enzymes. Among different compounds tested, compounds <b>1i</b> (IC<sub>50</sub> = 54.83 µg/ml), <b>1k</b> (IC<sub>50</sub> = 64.95 µg/ml), 1<b>m</b> (IC<sub>50</sub> = 64.78 µg/ml), and <b>1n</b> (IC<sub>50</sub> = 66.30 µg/ml) showed significant <i>α</i>-amylase inhibitor efficacy compared to the acarbose (IC<sub>50</sub> = 35.17 µg/ml); compounds <b>1m</b> (IC<sub>50</sub> = 74.64 µg/ml) and <b>1i</b> (IC<sub>50</sub> = 60.35 µg/ml) exhibited significant <i>α</i>-glucosidase inhibitory action compared to acarbose <b>(</b>IC<sub>50</sub> = 46.06 µg/ml). The docking study exhibited that compound <b>1i</b> creates six hydrogen bonds and compound <b>1m</b> forms three hydrogen bonding contacts at the active site of the enzyme (PDBID:4w93). The obtained results are demonstrated that compounds <b>1i, 1m, 1n, and 1k</b> had greater antidiabetic activities and can be further taken into consideration for antidiabetic therapeutic interventions.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 8","pages":"2221 - 2237"},"PeriodicalIF":2.2,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141783669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.1007/s13738-024-03072-0
Renan Fernando Rigueira, Gideã Taques Tractz, Daniela Aline Barancelli
Dye sensitized solar cell has been shown to be a promising technology for energy conversion. It presented in composition a scaffold material, an electrolyte, a counter electrode and a photosensiting molecule. Due to the costs of the most applied ruthenium-organic material, new compounds are synthesized with the aim of reducing costs. This work describes the synthesis and application of (E)-4-(4-hydroxy-3-methoxyphenyl) but-3-en-2-one (1), a monocarbonyl analog of curcumin, as a photosensiting material in a photovoltaic system. Devices were prepared using TiO2 as scaffold material sensitized with compound 1, graphene as a counter electrode, and I−/I3− as an electrolyte. The results showed the possibility of using new organic materials, providing an efficient device in energy conversion, with parameters of Jsc = 0.31 mA cm−2; Voc = 0.54 V, FF = 0.47, PCE = 0.07% and (tau_{n}) = 0.637 s.
{"title":"Fabrication of a dye sensitized solar cell using TiO2 sensitized with a mono-carbonyl curcumin analog","authors":"Renan Fernando Rigueira, Gideã Taques Tractz, Daniela Aline Barancelli","doi":"10.1007/s13738-024-03072-0","DOIUrl":"10.1007/s13738-024-03072-0","url":null,"abstract":"<div><p>Dye sensitized solar cell has been shown to be a promising technology for energy conversion. It presented in composition a scaffold material, an electrolyte, a counter electrode and a photosensiting molecule. Due to the costs of the most applied ruthenium-organic material, new compounds are synthesized with the aim of reducing costs. This work describes the synthesis and application of (<i>E</i>)-4-(4-hydroxy-3-methoxyphenyl) but-3-en-2-one (<b>1</b>), a monocarbonyl analog of curcumin, as a photosensiting material in a photovoltaic system. Devices were prepared using TiO<sub>2</sub> as scaffold material sensitized with compound 1, graphene as a counter electrode, and I<sup>−</sup>/I<sub>3</sub><sup>−</sup> as an electrolyte. The results showed the possibility of using new organic materials, providing an efficient device in energy conversion, with parameters of <i>J</i><sub>sc</sub> = 0.31 mA cm<sup>−2</sup>; <i>V</i><sub>oc</sub> = 0.54 V, FF = 0.47, PCE = 0.07% and <span>(tau_{n})</span> = 0.637 s.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 8","pages":"2095 - 2101"},"PeriodicalIF":2.2,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141783806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-24DOI: 10.1007/s13738-024-03075-x
Kiran Sabir Ali, Muhammad Sabir Zahoor, Muhammad Tariq, Hafiz Muhammad Asif, Shabbir Hussain, Jafir Hussain Shirazi
In the present study, we report fabrication of La@Co3O4 and La@CdO with rGO as new materials for NO2 sensing at a temperature range of 30–90 °C. The nanocomposites were characterized using various characterization tools like FTIR, Powder XRD and SEM to determine the composition and morphology of the nanocomposite sensors. The sensing properties such as sensor response, response time and recovery time were measured. The obtained results exhibited that rGO/La@Co3O4 showed a response of 2.9 while rGO /La@CdO is 2.4 at 50 °C. The sensor exhibited high selectivity to NO2, which is explained by a higher affinity for NO2 compared to other environmental pollutant gases like Cl2, NO, H2O and CO. The sensing mechanism was explained by the synergistic effect of reduced graphene with La@Co3O4 and La@CdO.
{"title":"Reduced graphene oxide with La@Co3O4 and La@CdO nanocomposite based sensors: synthesis, characterization and NO2 sensing properties","authors":"Kiran Sabir Ali, Muhammad Sabir Zahoor, Muhammad Tariq, Hafiz Muhammad Asif, Shabbir Hussain, Jafir Hussain Shirazi","doi":"10.1007/s13738-024-03075-x","DOIUrl":"10.1007/s13738-024-03075-x","url":null,"abstract":"<div><p>In the present study, we report fabrication of La@Co<sub>3</sub>O<sub>4</sub> and La@CdO with rGO as new materials for NO<sub>2</sub> sensing at a temperature range of 30–90 °C. The nanocomposites were characterized using various characterization tools like FTIR, Powder XRD and SEM to determine the composition and morphology of the nanocomposite sensors. The sensing properties such as sensor response, response time and recovery time were measured. The obtained results exhibited that rGO/La@Co<sub>3</sub>O<sub>4</sub> showed a response of 2.9 while rGO /La@CdO is 2.4 at 50 °C. The sensor exhibited high selectivity to NO<sub>2</sub>, which is explained by a higher affinity for NO<sub>2</sub> compared to other environmental pollutant gases like Cl<sub>2</sub>, NO, H<sub>2</sub>O and CO. The sensing mechanism was explained by the synergistic effect of reduced graphene with La@Co<sub>3</sub>O<sub>4</sub> and La@CdO.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 8","pages":"2067 - 2075"},"PeriodicalIF":2.2,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141783807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-23DOI: 10.1007/s13738-024-03069-9
Dariush Fallah, Mohammad Ali Zarei, Masoud Faal, Rohollah Zarei
The degradation temperature in high-energy materials is vital, and by predicting, it is possible to prevent the dangers of the degradation of high-energy materials and increase their safety. In this study, the degradation temperature of 63 energetic ionic liquids was investigated based on imidazole cation, and a mathematical model was presented to predict the degradation temperature of this class of materials. In this model, 20% of the data were randomly used as test data, and the rest were used as training sets. Correlation prediction (R2) in training and test data was 0.946 and 0.909, respectively. Also, in the internal leave-many-out cross-validation method, the average correlation is 0.953. The average absolute deviation and the root mean square deviation were calculated for both training and test groups. The results showed that the presented model for predicting the degradation temperature in energetic ionic liquids is highly accurate.
{"title":"A new equation for determine the degradation temperature in energetic ionic liquid","authors":"Dariush Fallah, Mohammad Ali Zarei, Masoud Faal, Rohollah Zarei","doi":"10.1007/s13738-024-03069-9","DOIUrl":"10.1007/s13738-024-03069-9","url":null,"abstract":"<div><p>The degradation temperature in high-energy materials is vital, and by predicting, it is possible to prevent the dangers of the degradation of high-energy materials and increase their safety. In this study, the degradation temperature of 63 energetic ionic liquids was investigated based on imidazole cation, and a mathematical model was presented to predict the degradation temperature of this class of materials. In this model, 20% of the data were randomly used as test data, and the rest were used as training sets. Correlation prediction (R<sup>2</sup>) in training and test data was 0.946 and 0.909, respectively. Also, in the internal leave-many-out cross-validation method, the average correlation is 0.953. The average absolute deviation and the root mean square deviation were calculated for both training and test groups. The results showed that the presented model for predicting the degradation temperature in energetic ionic liquids is highly accurate.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 8","pages":"2201 - 2210"},"PeriodicalIF":2.2,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141783808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-13DOI: 10.1007/s13738-024-03018-6
Ismail Khlifi, Imen Gouti, Santiago García-Granda, Hejer Litaiem
In the current research work, we investigated the growth of the new potassium arsenate tellurate material formulated as K2(HAsO4).Te(OH)6 (KAsTe) through the use of the slow preparation method. The (KAsTe) compound crystallized in the monoclinic system with centrosymmetric space group P21/c. Within this structure, two types of polyhedra (Te-O6 and HAsO4) were observed in the presence of K+ cations. The stability and the cohesion of the crystal structure were ensured by the linkage of different polyhedra via O‒H…O hydrogen bonds. To locate the closest contacts within this crystal structure, Hirshfeld surface analysis was performed. In fact, according to the fingerprint plots, we inferred that the hydrogen bonds constitute the dominant interactions present within this structure. The vibrational spectroscopy study at room temperature unveiled the occurrence and the independence of the ionic groups and provided detailed data on hydrogen bonds present in the crystal lattice. Thermal analyses (DSC, DTA, TG and MS) proved the presence of three phase transitions at 445, 514 and 555 K and indicated that no mass loss was recorded before 460 K. Furthermore, the σdc variation performed on (KAsTe) material suggested an important level of conductivity at high temperature, associated with the motion of H+ proton. This behavior goes in good agreement with the presence of the super‒ionic protonic phase transition at 445 K.
在当前的研究工作中,我们采用缓慢制备法研究了 K2(HAsO4).Te(OH)6(KAsTe)这一新型砷酸钾碲酸盐材料的生长情况。KAsTe)化合物在单斜体系中结晶,具有中心对称空间群 P21/c。在该结构中,观察到两种类型的多面体(Te-O6 和 HAsO4)存在于 K+ 阳离子中。不同多面体通过 O-H...O 氢键连接,确保了晶体结构的稳定性和内聚力。为了确定该晶体结构中最紧密接触点的位置,我们进行了 Hirshfeld 表面分析。事实上,根据指纹图,我们推断氢键是该结构中存在的主要相互作用。室温下的振动光谱研究揭示了离子基团的存在和独立性,并提供了晶格中氢键的详细数据。热分析(DSC、DTA、TG 和 MS)证明了在 445、514 和 555 K 时存在三个相变,并表明在 460 K 之前没有质量损失。这种行为与 445 K 时出现的超离子质子相变十分吻合。
{"title":"Structural characterization, atomic Hirshfeld surface analysis, thermal behavior, electric and vibrational studies of the new tellurate conductor material","authors":"Ismail Khlifi, Imen Gouti, Santiago García-Granda, Hejer Litaiem","doi":"10.1007/s13738-024-03018-6","DOIUrl":"10.1007/s13738-024-03018-6","url":null,"abstract":"<div><p>In the current research work, we investigated the growth of the new potassium arsenate tellurate material formulated as K<sub>2</sub>(HAsO<sub>4</sub>).Te(OH)<sub>6</sub> (KAsTe) through the use of the slow preparation method. The (KAsTe) compound crystallized in the monoclinic system with centrosymmetric space group P2<sub>1</sub>/c. Within this structure, two types of polyhedra (Te-O<sub>6</sub> and HAsO<sub>4</sub>) were observed in the presence of K<sup>+</sup> cations. The stability and the cohesion of the crystal structure were ensured by the linkage of different polyhedra via O‒H…O hydrogen bonds. To locate the closest contacts within this crystal structure, Hirshfeld surface analysis was performed. In fact, according to the fingerprint plots, we inferred that the hydrogen bonds constitute the dominant interactions present within this structure. The vibrational spectroscopy study at room temperature unveiled the occurrence and the independence of the ionic groups and provided detailed data on hydrogen bonds present in the crystal lattice. Thermal analyses (DSC, DTA, TG and MS) proved the presence of three phase transitions at 445, 514 and 555 K and indicated that no mass loss was recorded before 460 K. Furthermore, the σ<sub>dc</sub> variation performed on (KAsTe) material suggested an important level of conductivity at high temperature, associated with the motion of H<sup>+</sup> proton. This behavior goes in good agreement with the presence of the super‒ionic protonic phase transition at 445 K.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 8","pages":"2053 - 2066"},"PeriodicalIF":2.2,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141612683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-11DOI: 10.1007/s13738-024-03056-0
Mohamed A. M. Abdel Reheim, Gameel A. M. Elhagali, Khadija E. Saadon, Nadia M. H. Taha, N. A. Mahmoud, Mohamed. S. A. El-Gaby
The present work details the synthesis of several intriguing nitrogenous heterocycles utilizing a cyano-N-aryl-acetamide-reagent, notably chlorinated thiazolidine, thiophene and 2-iminochromene derivatives. Thus, the precursor 2-cyano-N-(2,4-dichlorophenyl) acetamide 1 underwent the reaction with phenyl isothiocyanate in DMF/KOH to afford the intermediate salt 3, which reacted in situ with several α-halogenated reagents 4a-c like ethylchloroacetate,α-bromoethylpropionate and α-bromo ethyl butaneoate and afforded the corresponding 4-thiazolidinnone derivatives (6a–c, yield%; 67–85), thiophene derivatives (11;yield 80%) and (15, yield 77%) obtained from the reaction of 3 with α- chloroacetyl acetone 9 and ethyl 2-chloro-3-oxobutanoate 12.Novel series of different 4-thiazolidinones(16a–e; yield%; 65–84) were obtained via condensation of 6a with different aldehydes. Finally, the reaction of compound 1 with different bifunctional reagents, such as salicylaldehyde derivatives and 2-hydroxynaphthaldehyde, in ethanol furnished the iminochromenes (17a,b; yield %77,80) and (18; yield 85%). In addition, molecular docking studies of the prepared molecules were carried out against papain-like protease (PLpro) to identify novel promising inhibitors of Coronavirus Disease COVID-19. The binding affinity of the best docked compounds 16c and 16a toward the target enzyme was − 9.6 and − 8.9 kcal/mole, respectively. In silico-docking-Studies indicate, that compounds 16c and 16a have the potential as antiviral against COVID-19.