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Dependence of the dental status of young individuals with different body weights on their eating behavior 不同体重青少年牙齿状况对饮食行为的影响
IF 0.2 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-35901
M. Skrypnyk, T. Petrushanko, K. Neporada, R. Skrypnyk, V. Petrushanko, I. Skrypnyk
Introduction. Obesity is a global problem of modern society. According to the WHO, in 2016, more than 1.9 billion adults are overweight and about 650 million adults are obese. Numerous studies indicate the role of overweight, obesity and metabolic status on periodontal health, however, the mechanism of their development is not fully understood. Aim. The aim of the study was to explore the mechanism of periodontal disease development in patients with diverse body mass index and the mechanism of extra weight and obesity onset in these patients. Methods. The study involved 132 Ukrainian males and females, 18 - 22 years old. Body mass index was determined in all patients. Information on life history, illness and family history was collected. The assessment of dental status was conducted by indicating the oral and tongue hygiene indices and periodontal indices. Eating behaviour was assessed using the standardised Dutch eating behaviour questionnaire (DEBG) and the three-factor eating questionnaire (TFEQ R-18). Diet assessment was determined by standardized diet questionnaire. Results. More than 60% of young people with the 1st and 2nd degree obesity had eating disorders, the most prevalent were disturbance of cognitive restraint and emotional eating components of eating behavior. The prevalence of periodontal disease was significantly higher in obese individuals, up to 87% in patients with the 1st and 2nd degree obesity. Conclusion. Eating behavior disturbances play a crucial role in the development of obesity in young adults and onset of gingivitis. The cause of non-plaque-induced gingivitis in patients with the 1st and 2nd degree obesity is a impaired general host response to the pathogenic factors of the oral cavity, caused by excess adipose tissue, which led to the development of chronic systemic mild inflammation. That is why these patients need a specific, integrated periodontal treatment.
介绍。肥胖是现代社会的一个全球性问题。根据世界卫生组织的数据,2016年,超过19亿成年人超重,约6.5亿成年人肥胖。大量研究表明,超重、肥胖和代谢状态对牙周健康的影响,但其发展机制尚不完全清楚。的目标。本研究旨在探讨不同体重指数患者牙周病发生的机制,以及这些患者超重和肥胖发生的机制。方法。这项研究涉及132名18 - 22岁的乌克兰男性和女性。测定所有患者的体重指数。收集生活史、疾病和家族史等信息。通过口腔、舌头卫生指标和牙周指标对口腔健康状况进行评估。采用标准荷兰饮食行为问卷(DEBG)和三因素饮食问卷(TFEQ R-18)对饮食行为进行评估。饮食评估采用标准化饮食问卷。结果。60%以上的一、二度肥胖青少年存在饮食失调,最常见的是认知约束障碍和饮食行为中的情绪性饮食成分。肥胖人群的牙周病患病率明显更高,在1度和2度肥胖患者中高达87%。结论。饮食行为障碍在年轻人肥胖的发展和牙龈炎的发病中起着至关重要的作用。1度和2度肥胖患者发生非菌斑性牙龈炎的原因是由于口腔内脂肪组织过多导致宿主对口腔致病因子的一般应答受损,从而发展为慢性全身性轻度炎症。这就是为什么这些患者需要特殊的、综合的牙周治疗。
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引用次数: 2
Triglyceride to high density lipoprotein cholesterol ratio is elevated in patients with complicated type 2 diabetes mellitus 2型糖尿病患者甘油三酯与高密度脂蛋白胆固醇比值升高
IF 0.2 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-33239
S. Bilgin, G. Aktas, Tel Atak, O. Kurtkulagi, G. Kahveci, T. Duman, Havva Akın, Buse Balci, Asli Erturk
Introduction/Aims: Microvascular and macrovascular complications lead to recurrent hospital admissions, hospitalizations, disability, and death in the course of type 2 diabetes mellitus (T2DM). Triglyceride to HDL cholesterol ratio (THR) is associated with insulin resistance. We aimed to find out whether there is a relationship between THR and diabetic complications in patients with T2DM. Methods: Patients with T2DM were enrolled in the study. The study population was divided into two groups according to the presence or absence of diabetic complications. Characteristics and laboratory data of the patients with (group A) and without (group B) diabetic complications were compared. Results: Median THR values of the groups A and B were 3.86 (0.33-53.38) and 2.86 (0.63-17.88), respectively (p = 0.006). THR level was significantly and positively correlated with glycated hemoglobin (HbA1c) (r = 0.12, p = 0.04) and fasting glucose levels (r = 0.14, p = 0.02). Conclusion: We suggest that THR should be monitored in patients with type 2 diabetes mellitus in order to detect diabetic microvascular complications earlier. Increased THR levels should prompt further investigation of diabetic complications in this population.
简介/目的:微血管和大血管并发症导致2型糖尿病(T2DM)过程中反复住院、住院、残疾和死亡。甘油三酯与高密度脂蛋白胆固醇比值(THR)与胰岛素抵抗有关。我们旨在了解T2DM患者THR与糖尿病并发症之间是否存在关系。方法:T2DM患者入组研究。研究人群根据有无糖尿病并发症分为两组。比较糖尿病合并组(A组)和非糖尿病合并组(B组)的特点和实验室资料。结果:A、B组THR中位数分别为3.86(0.33 ~ 53.38)、2.86(0.63 ~ 17.88),差异有统计学意义(p = 0.006)。THR水平与糖化血红蛋白(HbA1c) (r = 0.12, p = 0.04)和空腹血糖水平(r = 0.14, p = 0.02)呈显著正相关。结论:2型糖尿病患者应监测THR,以便及早发现糖尿病微血管并发症。THR水平升高应促使对这一人群的糖尿病并发症进行进一步调查。
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引用次数: 10
Evaluation of the clinical and biochemical parameters of hospitalized COVID-19 patients: A retrospective, single-center study from Bosnia and Herzegovina 波斯尼亚和黑塞哥维那住院COVID-19患者临床和生化指标评价:一项回顾性、单中心研究
IF 0.2 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-33738
A. Subo, A. Dervišević, Z. Omerbašić, M. Zeid, Selma Spahić, Almir Fajkić, D. Suljević
Background/Aim. For the first time, we evaluated and presented the socio-demographic characteristics, clinical manifestations and laboratory findings of hospitalized coronavirus disease 2019 (COVID-19) patients from Canton Sarajevo, Bosnia and Herzegovina. Methods. This retrospective, single-centre study included 159 RT-PCR verified COVID-19 patients (92 mild/moderate; 67 severe/critical) consecutively hospitalized at the General Hospital "Prim. dr Abdulah Nakaš" in Sarajevo, Bosnia and Herzegovina. Socio-demographic, clinical, and laboratory data on admission were retrospectively obtained from each patient's electronic medical record and patient files by two experienced physicians. Results. 43.4% of the patients belonged to the age range of 46-65 years; 71.1% were men, and 68.6% had comorbidities; hypertension was the most prevalent comorbidity (100%), followed by diabetes (91.7%) and ischemic heart disease (35.8%). The leading clinical symptoms were fever (87.44%), tiredness (77.8%), and body/muscle aches (70.3%). There was significant reduction of blood oxygen saturation (p = 0.005), and significant elevation of D-dimer (p = 0.003), CRP (p = 0.044), and fasting plasma glucose (p = 0.047) in the severe/critical patients group compared to mild/moderate group. Conclusion. Older age, the male gender, confirmed comorbidities, decreased blood oxygen saturation, increased levels of CRP, D-dimer, and fasting plasma glucose, together with symptoms of chest pain/shortness of breath and/or diarrhea occurred more frequently in severe/critical than mild/moderate COVID-19 patients.
背景/目的。首次对波黑萨拉热窝州2019冠状病毒病(COVID-19)住院患者的社会人口学特征、临床表现和实验室检查结果进行评估。方法。这项回顾性单中心研究纳入了159例经RT-PCR验证的COVID-19患者(92例轻/中度;67人(严重/危重)连续在波斯尼亚和黑塞哥维那萨拉热窝"普里姆·阿卜杜拉·纳卡什医生"总医院住院。入院时的社会人口学、临床和实验室数据由两名经验丰富的医生从每位患者的电子病历和患者档案中回顾性获取。结果:43.4%的患者年龄在46 ~ 65岁;71.1%为男性,68.6%有合并症;高血压是最常见的合并症(100%),其次是糖尿病(91.7%)和缺血性心脏病(35.8%)。主要临床症状为发热(87.44%)、疲劳(77.8%)、体/肌痛(70.3%)。与轻/中度组相比,重/危重组血氧饱和度显著降低(p = 0.005), d -二聚体(p = 0.003)、CRP (p = 0.044)、空腹血糖(p = 0.047)显著升高。结论。年龄较大、男性、确认的合并症、血氧饱和度降低、CRP、d -二聚体和空腹血糖水平升高,以及胸痛/呼吸短促和/或腹泻症状在重/危重型COVID-19患者中比轻/中度患者更常见。
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引用次数: 0
Neurological and psychiatric comorbidities in bullous pemphigoid 大疱性类天疱疮的神经和精神合并症
IF 0.2 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-35922
Arsovska Mirceska, K. Damevska, V. Simeonovski, A. Jović, D. Tiodorovic
Introduction: Bullous pemphigoid (BP) is an autoimmune skin disease that typically presents with severe itching and blistering, with or without eczematous and urticarial lesions. Patients with BP are at an increased risk of comorbid conditions, especially neurologic and psychiatric diseases. Several recent studies have found a link between BP and neurological disorders, especially stroke, dementia, and Parkinson's disease. The aim of our study was to evaluate the prevalence of neurological and psychiatric comorbidities and their treatment in BP patients. Methods: A cross-sectional, observational, descriptive study was conducted based on the analysis of the medical records of 105 patients with confirmed BP. Demographic and clinical data on BP, neurological and psychiatric comorbidities were collected and statistically analyzed for all patients. Results: The median age was 77.8±10.6 years (range, 39-98 years). Among the study group, 71 (67,61%) patients had neurological comorbidity. Comorbidity with the highest frequency was ischemic stroke found in 28 (26,67%) patients, followed by dementia in 27 (25,71%), Alzheimer's in 11 (10,48%) and Parkinson's disease 5 (4,76%) patients. It was noted that there was a statistically significant difference among male and female patients with Alzheimer's disease (p = 0,0046) and psychiatric disorder (p = 0,044). Conclusion: Neurological disorders usually precede the diagnosis of BP, and mortality may be higher in patients with comorbid conditions. Clinicians should be aware of the early signs and symptoms of BP, primarily in patients with primary neurological disorders such as dementia, stroke, or Parkinson's disease.
大疱性类天疱疮(BP)是一种自身免疫性皮肤病,通常表现为严重的瘙痒和水泡,伴有或不伴有湿疹和荨麻疹病变。BP患者出现合并症的风险增加,尤其是神经和精神疾病。最近的几项研究发现,血压与神经系统疾病,特别是中风、痴呆和帕金森病之间存在联系。本研究的目的是评估BP患者神经和精神合并症的患病率及其治疗方法。方法:对105例确诊BP患者的病历进行横断面、观察性、描述性研究。收集所有患者的血压、神经和精神合并症的人口学和临床数据并进行统计分析。结果:中位年龄77.8±10.6岁(范围39 ~ 98岁)。在研究组中,71例(67.61%)患者有神经系统合并症。共病发生率最高的是缺血性脑卒中28例(26.67%),其次是痴呆27例(25.71%),阿尔茨海默病11例(10.48%),帕金森病5例(4.76%)。值得注意的是,阿尔茨海默病(p = 0,0046)和精神障碍(p = 0,044)的男女患者之间存在统计学上的显著差异。结论:神经系统疾病通常先于BP的诊断,并且合并并发症的患者死亡率可能更高。临床医生应该意识到BP的早期症状和体征,尤其是在原发性神经系统疾病,如痴呆、中风或帕金森病的患者中。
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引用次数: 0
An overview of the hematological picture with antithyroid therapy in Graves' disease 格雷夫斯病抗甲状腺治疗的血液学图像综述
IF 0.2 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-36192
Aksanur Gokce, T. Omma, Mustafa Çelikc, I. Taşkaldıran
Aim: Graves' disease is an autoimmune thyroid disease that is the most common cause of hyperthyroidism. Peripheral blood cell parameters such as neutrophils, lymphocytes, and platelets play a role in inflammation control. Several studies have proven that neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio are indicators of chronic subclinical inflammation in various diseases. In our study, we aimed to review the peripheral blood picture by evaluating these parameters before and after antithyroid treatment in patients with Graves' disease. Patients and methods: A total of 120 patients (93 female, 27 male) between the ages of 18-65 were included. Demographic data, hemogram and biochemical data of the patients were recorded retrospectively at the time of diagnosis and after euthyroidism was achieved with medical treatment. Results: During the treatment, there was an increase in hemoglobin, lymphocytes, neutrophils and red cell distribution width, while a decrease in monocytes was observed. There was no significant difference between white blood cell, platelet and mean platelet volume. In addition, while there was no statistically significant difference between neutrophil-lymphocyte ratio (p = 0.8) and thrombocyt-lymphocyte ratio (p = 0.078) after euthyroid state, a statistically significant difference was found in favor of a decrease in monocyte-lymphocyte ratio (p = 0.006). Conclusion: Changes in hematopoiesis are relatively common in patients with newly diagnosed Graves' disease, and initiation of antithyroid therapy leads to improvement in these parameters. Although neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio are accepted as new, non-invasive markers in clinical evaluation, in our study only a significant decrease in monocyte-lymphocyte ratio levels was observed after euthyroidism was achieved with antithyroid treatment.
目的:Graves病是一种自身免疫性甲状腺疾病,是甲状腺功能亢进的最常见原因。外周血细胞参数如中性粒细胞、淋巴细胞和血小板在炎症控制中起作用。多项研究证实,中性粒细胞-淋巴细胞比率、单核细胞-淋巴细胞比率和血小板-淋巴细胞比率是多种疾病慢性亚临床炎症的指标。在我们的研究中,我们旨在通过评估Graves病患者抗甲状腺治疗前后的这些参数来回顾外周血图像。患者和方法:共纳入120例患者,其中女性93例,男性27例,年龄18-65岁。回顾性记录患者在诊断时及经治疗后甲状腺功能恢复正常时的人口学资料、血象及生化指标。结果:治疗期间,血红蛋白、淋巴细胞、中性粒细胞及红细胞分布宽度增加,单核细胞减少。白细胞、血小板及平均血小板体积差异无统计学意义。甲状腺功能正常后中性粒细胞-淋巴细胞比值(p = 0.8)和血小板-淋巴细胞比值(p = 0.078)差异无统计学意义,单核细胞-淋巴细胞比值下降有统计学意义(p = 0.006)。结论:造血功能改变在新诊断的Graves病患者中较为常见,抗甲状腺治疗的开始可改善这些参数。虽然中性粒细胞-淋巴细胞比率、单核细胞-淋巴细胞比率和血小板-淋巴细胞比率被认为是临床评估中新的、无创的指标,但在我们的研究中,只有在抗甲状腺治疗达到甲状腺功能正常后,单核细胞-淋巴细胞比率水平才有显著下降。
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引用次数: 0
Eating and swallowing disorders in children with cleft lip and/or palate 唇裂和/或腭裂儿童饮食和吞咽障碍
IF 0.2 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-30733
J. Todorović, Mirna Zelić, Lana Jerkić
Introduction. Cleft lip and palate are complex congenital anomalies of the orofacial system of children. Feeding and swallowing problems occur with varying degrees in children with cleft lip and/or palate. Aim. The aim of this paper was to review the literature and available evidence regarding the types of eating and swallowing disorders that can be identified in children with cleft lip and/or palate, as well as a description and types of compensatory strategies and interventions to alleviate difficulties. Methods. Insight into the relevant literature was performed by specialized search engines on the internet and insight into the electronic database. Results. The extent of the cleft is related to the severity of eating and swallowing disorders, so the most common problems are decreased oral sensitivity, cough, choking, nasal regurgitation, difficulty in sucking, laryngotracheal aspiration due to inadequate airway protection during swallowing, which may result in pneumonia and lung damage. Feeding and swallowing difficulty is also a source of stress for parents. Conclusion. Choking, coughing, nasal regurgitation, laryngotracheal aspiration, excessive air intake can lead to dehydration, malnutrition, but also the need for alternative feeding methods Therefore, it is of great importance to identify the problems of feeding and swallowing in a timely manner, along with modifications of the feeding method.
介绍。摘要唇腭裂是儿童复杂的先天性口面系统畸形。唇裂和/或腭裂患儿存在不同程度的进食和吞咽问题。的目标。本文的目的是回顾文献和现有的证据,关于可以在唇裂和/或腭裂儿童中识别的饮食和吞咽障碍的类型,以及描述和类型的补偿策略和干预措施,以减轻困难。方法。通过互联网上的专门搜索引擎和电子数据库对相关文献进行深入研究。结果。唇裂的程度与进食和吞咽障碍的严重程度有关,因此最常见的问题是口腔敏感性下降、咳嗽、窒息、鼻反流、吸吮困难、吞咽时由于气道保护不足导致的喉气管误吸,这些都可能导致肺炎和肺部损伤。喂养和吞咽困难也是父母压力的一个来源。结论。窒息、咳嗽、鼻反流、喉气管误吸、吸入空气过多均可导致脱水、营养不良,还需要更换喂养方式,因此,及时发现喂养和吞咽的问题,并对喂养方式进行修改是非常重要的。
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引用次数: 0
Dietary and lifestyle habits of patients with type 2 diabetes in Subotica 苏博蒂察2型糖尿病患者的饮食和生活习惯
IF 0.2 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-34287
Hajnalka Požar, D. Simin, Čaba Požar
Introduction: The activities of the health care service in the control of diabetes and the improvement of glucoregulation of patients are primarily focused on lifestyle modification. The goal of this study was to review the recommendations in the field of adequate nutrition and lifestyle and to assess the health behavior of patients with type 2 diabetes in Subotica. Methodology: The research was conducted in the form of a cross-sectional study in February 2017 at the Diabetes Counseling Center of the Health Center in Subotica, Serbia. The study included 114 patients with type 2 diabetes. The research instrument consisted of a customized survey questionnaire. Results: Only a third of the patients actually consumed at least five meals a day, that was suggested as part of the treatment. Three-quarters of patients always prepared their own meals, but 41% of them never read the declarations about the ingredients of the food they consumed. Twenty percent of patients did not know how to assemble a healthy plate and what low-carbohydrate foods were. Two-thirds of patients used dietary supplements. A relatively small number, one-quarter of patients, consumed alcoholic beverages and 22 patients were active smokers. More than half of the patients exercised lightly, although 68% of them were dissatisfied with their body weight. Conclusion: We identified some deficiencies in the health behavior and lifestyle of people with diabetes. There is a recommendation to repeat the information on proper nutrition and the importance of physical activity in achieving ideal health and optimal glucoregulation during the educational work with patients.
导言:保健服务在控制糖尿病和改善患者血糖调节方面的活动主要集中在生活方式的改变上。本研究的目的是回顾苏博蒂卡地区关于充足营养和生活方式的建议,并评估2型糖尿病患者的健康行为。方法:该研究于2017年2月在塞尔维亚Subotica健康中心的糖尿病咨询中心以横断面研究的形式进行。该研究包括114名2型糖尿病患者。研究工具包括定制的调查问卷。结果:只有三分之一的患者实际上每天至少吃五顿饭,这是建议作为治疗的一部分。四分之三的患者总是自己做饭,但41%的患者从不阅读他们所吃食物的成分说明。20%的患者不知道如何搭配健康餐盘,也不知道什么是低碳水化合物食物。三分之二的患者使用膳食补充剂。相对较少的患者(四分之一)饮用酒精饮料,22名患者是活跃的吸烟者。尽管68%的患者对自己的体重不满意,但超过一半的患者运动量不大。结论:我们发现糖尿病患者的健康行为和生活方式存在一些不足。建议在对患者的教育工作中重复适当的营养和体育活动对实现理想健康和最佳血糖调节的重要性的信息。
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引用次数: 0
Textural and sensory characterization of carbomeric gels with panthenol 泛醇碳聚物凝胶的结构和感官特性
IF 0.2 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-31063
M. Martinović, Nenad Stojanović, I. Nešić
Introduction. The aim of this study was to evaluate the influence of the carbomer concentration (used as the gelling agent, in the range 0.5 - 2.0%) on textural and sensory characteristics of gels with 3% panthenol using sensory analysis as subjective and texture analysis as an objective assessment method. An active substance in the gels was panthenol, which also acted as a neutralizing agent of the carbomer. Participants and methods. Twenty female panelists, aged between 20 and 36, participated in the sensory study and had to fulfill a questionnaire regarding product attributes before, during and after application on the skin. Texture analysis was performed on CT3 Texture Analyzer, after each week for a month, and the following parameters were calculated: hardness cycle 1, hardness cycle 2, cohesiveness, adhesiveness, resilience and springiness. Results. The results showed that gels were stable over time and the structure of the gels was preserved regardless of compression. An increase in hardness and resilience was followed by an increase in the concentration of carbomer, while adhesiveness, cohesiveness and springiness did not differ much among different gels. The same trend was noticed when gels were compared during time. Sensory analysis confirmed findings of texture analysis and showed that with the increment of carbomer concentration, stickiness and density also enhanced, while absorption rate and spreadability decreased. Gel with 1% carbomer was chosen by the majority of panelists as favorite and as a gel they would regularly use. Conclusion. The methods of textural and sensory analysis represent valuable approaches in drug/cosmetic product design because they offer insight in the compliance of patients/consumers.
介绍。本研究的目的是评价卡波姆浓度(用作胶凝剂,在0.5 - 2.0%范围内)对3%泛醇凝胶的结构和感官特性的影响,以感官分析为主观评价方法,结构分析为客观评价方法。凝胶中的一种活性物质是泛醇,它也是卡波姆的中和剂。参与者和方法。20名年龄在20至36岁之间的女性小组成员参加了感官研究,并在皮肤上使用产品之前,期间和之后填写了一份关于产品属性的问卷。在CT3织构分析仪上进行织构分析,每周一次,连续一个月,计算硬度周期1、硬度周期2、内聚性、黏附性、回弹性、弹性等参数。结果。结果表明,随着时间的推移,凝胶是稳定的,无论压缩凝胶的结构保持不变。硬度和回弹性的增加伴随着卡波姆浓度的增加,而黏附性、内聚性和弹性在不同凝胶之间差异不大。同样的趋势也被注意到,当凝胶在一段时间内进行比较。感官分析证实了织构分析的结果,表明随着卡波姆浓度的增加,黏性和密度增加,吸收率和铺展性降低。含有1%卡波姆的凝胶被大多数小组成员选为他们最喜欢的凝胶,也是他们经常使用的凝胶。结论。质地和感官分析方法代表了药物/化妆品设计中有价值的方法,因为它们提供了对患者/消费者依从性的洞察。
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引用次数: 1
The influence of selected thickeners on the textural properties of oil-in-water emulsions 选择增稠剂对水包油乳剂结构性能的影响
IF 0.2 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-31064
Aleksandra Stolić-Jovanović, M. Martinović, I. Nešić
Introduction. Texture profile analysis, as the most popular method of texture analysis today, is used for relating the mechanical characteristics of the samples to their sensory characteristics. Thickeners have an important influence on the mechanical properties of semi-solid products, and thus on the physical stability of creams. Choosing the right one often requires more skill than knowledge. Aims. The aim of this study was to evaluate the influence of thickeners-natural (xanthan gum) as well as naturally modified polymers (hydroxyethylcellulose, c) at the concentration of 1% w/w on the textural properties of oil-in-water emulsions. Results and Discussion. The following parameters of the tested emulsions were determined: adhesiveness, cohesiveness, and hardness. All tested creams reached higher adhesiveness values at the end of the study compared to the originally measured values. However, the presence of thickeners did not increase the stickiness of the formulations since the adhesiveness of the tested samples did not differ much compared to the control sample. Almost similar values of cohesiveness were measured for all samples compared to the initial values. The values of hardness showed that the deformation after two compression cycles did not disrupt the structure and that all preparations were of similar spreadability. Conclusion. The results obtained by texture analysis could be used in the formulation of a cosmetic product with predefined sensory characteristics. Also, they could help in finding an adequate combination and concentration of thickeners for their application in the formulation. Further research should be directed towards the application of more different thickeners and different ranges of their concentrations in the formulation.
介绍。纹理轮廓分析是当今最流行的纹理分析方法,用于将样品的力学特性与其感官特性联系起来。增稠剂对半固体产品的机械性能有重要影响,从而对乳膏的物理稳定性有重要影响。选择合适的人往往需要更多的技巧而不是知识。目标本研究的目的是评价天然增稠剂(黄原胶)和天然改性聚合物(羟乙基纤维素,c)在1% w/w浓度下对水包油乳液结构性能的影响。结果和讨论。测定了乳状液的粘附性、内聚性和硬度。与最初的测量值相比,所有测试的面霜在研究结束时都达到了更高的粘附性值。然而,增稠剂的存在并没有增加配方的粘性,因为测试样品的粘性与对照样品相比没有太大差异。与初始值相比,所有样品的内聚性测量值几乎相似。硬度值表明,经过两次压缩循环后的变形没有破坏结构,并且所有的制备都具有相似的铺展性。结论。织构分析的结果可用于具有预定感官特性的化妆品配方。此外,它们还可以帮助找到适当的增稠剂组合和浓度,以便在配方中应用。进一步的研究应着眼于在配方中应用更多不同的增稠剂及其不同的浓度范围。
{"title":"The influence of selected thickeners on the textural properties of oil-in-water emulsions","authors":"Aleksandra Stolić-Jovanović, M. Martinović, I. Nešić","doi":"10.5937/afmnai39-31064","DOIUrl":"https://doi.org/10.5937/afmnai39-31064","url":null,"abstract":"Introduction. Texture profile analysis, as the most popular method of texture analysis today, is used for relating the mechanical characteristics of the samples to their sensory characteristics. Thickeners have an important influence on the mechanical properties of semi-solid products, and thus on the physical stability of creams. Choosing the right one often requires more skill than knowledge. Aims. The aim of this study was to evaluate the influence of thickeners-natural (xanthan gum) as well as naturally modified polymers (hydroxyethylcellulose, c) at the concentration of 1% w/w on the textural properties of oil-in-water emulsions. Results and Discussion. The following parameters of the tested emulsions were determined: adhesiveness, cohesiveness, and hardness. All tested creams reached higher adhesiveness values at the end of the study compared to the originally measured values. However, the presence of thickeners did not increase the stickiness of the formulations since the adhesiveness of the tested samples did not differ much compared to the control sample. Almost similar values of cohesiveness were measured for all samples compared to the initial values. The values of hardness showed that the deformation after two compression cycles did not disrupt the structure and that all preparations were of similar spreadability. Conclusion. The results obtained by texture analysis could be used in the formulation of a cosmetic product with predefined sensory characteristics. Also, they could help in finding an adequate combination and concentration of thickeners for their application in the formulation. Further research should be directed towards the application of more different thickeners and different ranges of their concentrations in the formulation.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
In vitro assessment of the lipid peroxidation of N,N'-disubstituted benzimidazole-2-thiones: Hydrazides vs esters N,N'-二取代苯并咪唑-2-硫酮脂质过氧化的体外评价:肼类与酯类
IF 0.2 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-36399
J. Lazarević, J. Zvezdanović, N. Anastassova, A. Mavrova, D. Yancheva, A. Šmelcerović
Introduction: Oxidative stress and resulting lipid peroxidation are involved in numerous pathological conditions. For this reason, the role of antioxidants attracts attention and the radical-scavenging capacity of many natural and synthetic supplements and drugs has been extensively evaluated. Material and methods: In the present study, seven N,N'-disubstituted benzimidazole-2-thiones with ester (1 - 4) and hydrazide (5 - 7) side chains were investigated for in vitro antioxidant activity using lipid peroxidation method. Results: Among the assayed compounds, three hydrazides, 1,3-bis[3-(hydrazinooxy)-3-oxopropyl]-1,3dihydro-2H-benzimidazole-2-thione (5), 1,3-bis[3-(hydrazinooxy)-3-oxopropyl]-5-methyl-1,3-dihydro-2H benzimidazole-2-thione (6) and 1,3-bis[3-(hydrazinooxy)-3-oxopropyl]-5-benzoyl-1,3-dihydro-2H benzimidazole-2-thione (7) showed good antioxidant properties (IC50 ˂ 100 mM), with the best lipid peroxidation inhibition values (IC50) shown for compound 5 (64 ± 10 mM) and compound 6 (73 ± 29 mM). Conclusion: Indicated hydrazide structures may constitute a sort of molecular basis, a promising starting point for the development of compounds for the prevention and treatment of diseases resulting from oxidative damage.
简介:氧化应激和由此产生的脂质过氧化涉及许多病理条件。因此,抗氧化剂的作用引起了人们的关注,许多天然的和合成的补充剂和药物的自由基清除能力已经得到了广泛的评估。材料与方法:本研究采用脂质过氧化法研究了7种具有酯(1 - 4)和肼(5 - 7)侧链的N,N'-二取代苯并咪唑-2-硫酮的体外抗氧化活性。结果:在化验化合物,三酰肼类,1,二(3 - (hydrazinooxy) 3-oxopropyl] 1、3 dihydro-2h-benzimidazole-2-thione(5), 1,二[3 - (hydrazinooxy) 3-oxopropyl] 5-methyl-1 3-dihydro-2H benzimidazole-2-thione(6)和1,二[3 - (hydrazinooxy) 3-oxopropyl] 5-benzoyl-1 3-dihydro-2H benzimidazole-2-thione(7)显示良好的抗氧化性能(IC50˂100毫米),用最好的脂质过氧化抑制值(IC50)所示化合物5(64±10毫米),化合物6(73±29毫米)。结论:已知的肼结构可能构成一种分子基础,为开发预防和治疗氧化损伤引起的疾病的化合物提供了良好的起点。
{"title":"In vitro assessment of the lipid peroxidation of N,N'-disubstituted benzimidazole-2-thiones: Hydrazides vs esters","authors":"J. Lazarević, J. Zvezdanović, N. Anastassova, A. Mavrova, D. Yancheva, A. Šmelcerović","doi":"10.5937/afmnai39-36399","DOIUrl":"https://doi.org/10.5937/afmnai39-36399","url":null,"abstract":"Introduction: Oxidative stress and resulting lipid peroxidation are involved in numerous pathological conditions. For this reason, the role of antioxidants attracts attention and the radical-scavenging capacity of many natural and synthetic supplements and drugs has been extensively evaluated. Material and methods: In the present study, seven N,N'-disubstituted benzimidazole-2-thiones with ester (1 - 4) and hydrazide (5 - 7) side chains were investigated for in vitro antioxidant activity using lipid peroxidation method. Results: Among the assayed compounds, three hydrazides, 1,3-bis[3-(hydrazinooxy)-3-oxopropyl]-1,3dihydro-2H-benzimidazole-2-thione (5), 1,3-bis[3-(hydrazinooxy)-3-oxopropyl]-5-methyl-1,3-dihydro-2H benzimidazole-2-thione (6) and 1,3-bis[3-(hydrazinooxy)-3-oxopropyl]-5-benzoyl-1,3-dihydro-2H benzimidazole-2-thione (7) showed good antioxidant properties (IC50 ˂ 100 mM), with the best lipid peroxidation inhibition values (IC50) shown for compound 5 (64 ± 10 mM) and compound 6 (73 ± 29 mM). Conclusion: Indicated hydrazide structures may constitute a sort of molecular basis, a promising starting point for the development of compounds for the prevention and treatment of diseases resulting from oxidative damage.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71196002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Acta Facultatis Medicae Naissensis
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