Journal of engineering and science in medical diagnostics and therapy最新文献_第8页

Finite Element Analysis of Maxillary Anterior Dentition During Retraction with Varying Level of Bone Support 上颌前牙列在不同骨支持水平下后缩的有限元分析

Journal of engineering and science in medical diagnostics and therapy

Pub Date : 2023-03-21 DOI: 10.1115/1.4062158

J. Biswas, Rururaj Pradhan, N. Mondal, Sejuti Ballav, Masud Rana

This study is being carried out to evaluate and compare the stress along the root surfaces of anterior maxillary dentition during retraction in labial and lingual mechanics with varying level of bone support. Eight 3D Finite Element models (FEM) were created with normal periodontium and different levels of alveolar bone loss; four with labial brackets and four with lingual brackets. Sliding mechanics were simulated as en-masse retraction of the anterior dentition. The equivalent stresses along the roots of six anterior maxillary teeth were measured in all the models. Equivalent stresses generated at the root surfaces of central incisors are always higher in labial technique and of canines are always higher in lingual technique, suggesting the increased vulnerability towards root resorption in both cases. Stresses at the root apices of all the teeth are increasing progressively when the bone loss is progressively more than 2mm in labial technique. In labial technique, the stresses at the root apices of all the teeth are increasing progressively when the bone loss is progressively more than 2mm. In Lingual technique, equivalent stresses generated at the root surfaces of canines are more than central and lateral incisors irrespective of the alveolar bone loss, suggesting increased susceptibility to root resorption.

本研究旨在评估和比较上颌前牙列在不同骨支持水平下，在唇和舌力学中，沿根表面的应力。建立正常牙周组织和不同程度牙槽骨丢失的8个三维有限元模型;四个有唇托四个有舌托。滑动力学模拟为前牙列的大规模内缩。所有模型均测量了6颗上颌前牙沿牙根方向的等效应力。中切牙根面产生的等效应力在唇部技术上总是更高，而犬科在舌部技术上总是更高，这表明在这两种情况下，对根吸收的脆弱性都增加了。在唇部技术中，当骨质流失逐渐超过2mm时，所有牙齿的根尖应力逐渐增加。在唇部技术中，当骨质流失逐渐超过2mm时，所有牙齿的根尖应力逐渐增加。在舌技术中，与牙槽骨丢失无关，犬牙根表面产生的等效应力大于中门牙和侧门牙，这表明牙根吸收的易感性增加。

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引用次数: 0

A Microrobot With an Attached Microforce Sensor for Transurethral Access to the Bladder Interior Wall 一种带有附加微力传感器的经尿道膀胱内壁微型机器人

Journal of engineering and science in medical diagnostics and therapy

Pub Date : 2023-03-20 DOI: 10.1115/1.4056884

Samson Adejokun, Shashank Kumat, Panos Shiakolas

Abstract We present the conceptual design and limited functionality prototype and characterization of a system for application in transurethral palpation of any targeted area of the bladder interior wall tissue consisting of a robotic manipulator and a microforce sensor attached at its tip all less than 3.5 mm in diameter. A hyper-redundant ten-joint six degrees-of-freedom (6DOF) manipulator (5DOF rigid and five-joint continuum segments) is presented along with the forward and inverse kinematics analyses based on a Jacobian formulation to prevent configuration singularities. Simulated motion studies demonstrate the ability of the proposed manipulator to attain a desired pose (normal to the tissue) with any area in the bladder including the difficult to reach trigone area. A strain gauge-based microforce sensor is designed using finite element analysis (safety factor > 3), prototyped using additive manufacturing, and characterized. The characterized sensor was used to acquire in vivo measurements to evaluate human palm tissue viscoelastic properties. A single module of the continuum segment is designed and prototyped using additive manufacturing, and used to characterize its tension-bend angle behavior. Finite element analysis is used to improve structurally weak regions of the vertebra. A three-joint four-vertebrae prototype was successfully actuated to reach a bend state using tendons. The developed robot and sensor prototypes demonstrate capabilities of the proposed concept which could be a possible solution to quantitatively evaluate localized biomechanical properties of the bladder tissue to improve treatment and provide better patient care.

摘要:我们介绍了一种用于经尿道膀胱内壁组织任何目标区域触诊的系统的概念设计和有限功能原型和特性，该系统由机器人机械手和附着在其尖端的微力传感器组成，其直径小于3.5 mm。提出了一种超冗余十关节六自由度机械臂(五自由度刚性段和五关节连续段)，并基于防止位形奇异的雅可比矩阵进行了正运动学和逆运动学分析。模拟运动研究表明，所提出的机械臂能够在膀胱的任何区域(包括难以到达的三角区)达到所需的姿势(与组织正常)。利用有限元分析(安全系数)设计了一种基于应变片的微力传感器。3)，使用增材制造进行原型制作，并进行表征。该传感器被用于获得体内测量，以评估人体手掌组织的粘弹性特性。使用增材制造技术对连续体段的单个模块进行了设计和原型制作，并用于表征其拉伸弯曲角行为。有限元分析用于改善椎体结构薄弱区域。一个三关节四椎体原型成功地使用肌腱达到弯曲状态。开发的机器人和传感器原型展示了所提出概念的能力，这可能是定量评估膀胱组织局部生物力学特性的可能解决方案，以改善治疗并提供更好的患者护理。

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引用次数: 1

Quantifying Stent Wall Shear Stress for Assessing Stent and Flow Diverter Performance for Treating Intracranial Aneurysms 量化支架壁剪切应力以评估支架和血流分流器治疗颅内动脉瘤的性能

Journal of engineering and science in medical diagnostics and therapy

Pub Date : 2023-03-11 DOI: 10.1115/1.4062107

T. Suess, S. Gent

Analysis of flow diverting intracranial aneurysm repair devices has traditionally focused on reducing intrasaccular blood flow velocity and aneurysm wall shear stress (WSS) as the primary metrics for improved perceived device performance. However, the interpretation of this data has been debated, particularly with regards to the specific biological benefits of high or low aneurysm WSS. Therefore, this research proposes an additional parameter of WSS at the stent struts that could provide valuable insight regarding the device's potential to promote occlusion at the aneurysm neck by indicating locations of increased platelet activation and microparticle shedding. Fluid flow effects were evaluated for two flow diverters (PipelineTM and FREDTM) and three stents (EnterpriseTM, AtlasTM, and LVISTM) using computational fluid dynamics (CFD) models developed from two patient-derived CTA datasets with aneurysms in the middle cerebral artery (MCA) and basilar artery (BA), respectively. The device WSS data provides an additional metric for evaluating the ability of the device to constrain the blood flow within the main vessel, as well as indicating potential locations of the initiation of aneurysm occlusion. It is hypothesized that high device WSS close to the aneurysm neck creates a higher likelihood of thrombus formation and aneurysm occlusion due to platelet activation and microparticle shedding, while high device WSS proximal or distal on the device would indicate higher likelihood of undesirable daughter vessel occlusion. Conversely, low-to-moderate device WSS throughout the device length could be interpreted as a reduced likelihood of complete occlusion of the aneurysm over time, resulting in lesser device performance.

传统上，对分流颅内动脉瘤修复装置的分析主要集中在降低囊内血流速度和动脉瘤壁剪切应力(WSS)上，这是改善感知装置性能的主要指标。然而，对这些数据的解释一直存在争议，特别是关于高或低动脉瘤WSS的特定生物学益处。因此，本研究提出了支架支撑处WSS的附加参数，该参数可以通过指示血小板活化增加和微粒脱落的位置，为该装置促进动脉瘤颈部闭塞的潜力提供有价值的见解。使用计算流体动力学(CFD)模型评估两种分流器(PipelineTM和FREDTM)和三种支架(EnterpriseTM, AtlasTM和LVISTM)的流体流动效果，这些模型分别来自两个大脑中动脉(MCA)和基底动脉(BA)动脉瘤患者的CTA数据集。设备WSS数据为评估设备限制主血管内血流的能力以及指示动脉瘤闭塞起始的潜在位置提供了额外的指标。假设靠近动脉瘤颈部的高装置WSS由于血小板活化和微粒脱落导致血栓形成和动脉瘤闭塞的可能性更高，而装置近端或远端的高装置WSS则表明更有可能出现不良的子血管闭塞。相反，在整个装置长度中，低至中等的装置WSS可以解释为随着时间的推移，动脉瘤完全闭塞的可能性降低，从而导致较低的装置性能。

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引用次数: 0

A Vibrating-string Model for Closed-loop Wave Transmission and Reflection Between the Aorta and Periphery 主动脉与外周间闭环波传输与反射的振动弦模型

Journal of engineering and science in medical diagnostics and therapy

Pub Date : 2023-03-08 DOI: 10.1115/1.4062078

Z. Hao

A tube-load model is used to reconstruct aortic pressure waveform from peripheral pressure waveform. Yet, the reconstructed aortic pressure waveform is greatly affected by load impedance used. In this work, a vibrating-string model for closed-loop wave transmission and reflection between the aorta and periphery is developed to examine the roles of all the parameters involved in aortic pressure waveform. The arterial pulsatile wave theory gives rise to the standard 1D wave equation for a vibrating string. A vibrating-string model based on radial displacement of the arterial wall is developed to relate aortic pressure waveform to peripheral pressure waveform, relate load impedance to input impedance, and derive theoretical expressions for associated clinical indices. The vibrating-string model is extended to incorporate blood velocity, and is further connected to the left ventricle (LV) to study the role of the LV in aortic pressure waveform. The difference between the vibrating-string model and the tube-load model is also examined. Load impedance is identified as an indispensable independent parameter for reconstruction of aortic pressure waveform with accuracy, and its physiologically realistic harmonic-dependence can only be obtained from the measured input impedance. The derived expressions for clinical indices interpret some clinical findings and underscore the role of harmonics in clinical indices. Some misconceptions in the tube-load model are revealed, including load impedance and characteristic impedance. This work clarifies the role of harmonics-dependence of load impedance and harmonics of aortic pressure waveform in determining clinical indices.

采用管载模型从外周压力波形重构主动脉压力波形。然而，重构的主动脉压波形受负载阻抗的影响较大。在这项工作中，建立了主动脉和周围之间闭环波传输和反射的振动弦模型，以检查主动脉压力波形中涉及的所有参数的作用。动脉脉动波理论给出了振动弦的标准一维波动方程。建立了基于动脉壁径向位移的振动弦模型，将主动脉压力波形与外周压力波形、负载阻抗与输入阻抗联系起来，推导出相关临床指标的理论表达式。将振动弦模型进行扩展，纳入血流速度，并进一步连接左心室(LV)，研究左心室在主动脉压波形中的作用。分析了弦振模型与管柱载荷模型的差异。负载阻抗是准确重建主动脉压波形不可缺少的独立参数，其生理真实的谐波依赖性只能由测量的输入阻抗获得。推导出的临床指标表达式解释了一些临床发现，强调了谐波在临床指标中的作用。揭示了管负载模型中存在的一些误解，包括负载阻抗和特性阻抗。这项工作阐明了负载阻抗的谐波依赖性和主动脉压波形的谐波在确定临床指标中的作用。

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引用次数: 0

Effect of Force Field On Deformation and Migration of Single Cell with Orientation Controlled by Micro-striped Topography Patterns 力场对微条纹形貌控制取向的单细胞变形和迁移的影响

Journal of engineering and science in medical diagnostics and therapy

Pub Date : 2023-03-03 DOI: 10.1115/1.4057030

S. Hashimoto, Kazuya Kishimoto

The effect of the force field parallel to the surface of the scaffold plate on cell activity (deformation, migration) has been studied in vitro. Cell orientation was aligned by microtopography patterns (striped ridgelines; height 0.7 μm, width 3 μm, spacing 3 μm) on the scaffold plane. Three compartments were designed with different angles (0 degrees, 45 degrees, and 90 degrees) between the longitudinal direction of the ridge and the direction of the force field. Osteoblasts (MC3T3-E1; osteoblast precursor cell line derived from mouse calvaria) were used in the experiment. After applying a force field for 5 hours, the position and contour of each cell were tracked on time-lapse microscopy images for 48 hours. Experimental results show that force fields not parallel to the major axis of the cell activate subsequent actions (deformation, migration) of the cell. The effect is maintained for 48 hours even if the cells move to different areas of the topography pattern.

体外实验研究了平行于支架板表面的力场对细胞活性(变形、迁移)的影响。微地形模式(条纹脊线;脚手架平面高度0.7 μm，宽度3 μm，间距3 μm。在脊线纵向与力场方向之间设计了3个不同角度(0度、45度和90度)的隔室。成骨细胞(MC3T3-E1;实验采用从小鼠颅骨中提取的成骨前体细胞。施加力场5小时后，在延时显微镜图像上追踪每个细胞的位置和轮廓48小时。实验结果表明，不平行于细胞长轴的力场会激活细胞的后续动作(变形、迁移)。即使细胞移动到地形模式的不同区域，这种效果也能维持48小时。

引用次数: 0

Investigation of Mechanical Behaviors of Dental Implants with Different Geometries 不同几何形状种植体力学行为的研究

Journal of engineering and science in medical diagnostics and therapy

Pub Date : 2023-02-24 DOI: 10.1115/1.4056952

Zhongxia Yuan, P. L. Chong, Sandipan Roy, A. Merdji, Abdelhak Ouldyerou, F. Faraji, L. K. Moey, Mohammad Hossein Yazdi, O. Mukdadi

Dental implants have received a lot of attention and have been used to treat symptoms like missing teeth and bad teeth. Due to the wide range of occupations and ages of patients, the functions and aims of implants are different. There are many kinds of dental implant shapes. However, with the popularity of dental implants, some problems caused by the dental implant shape have appeared in people's eyes. In fact, some implants were used incorrectly. This makes the stress distribution around the implant unreasonable; it not only affects the surrounding bone resorption but also causes mechanical fracture of the implant. This work aims to evaluate the mechanical features of five different kinds of dental implant systems. By applying engineering systems of investigations like FEM, five types of dental implants and surrounding bone tissue were modeled and simulated under vertical loads of 90N. Distributions of stresses and deformations in the bone were obtained and ranked into statistical scores, which were used to judge the optimum geometry of implants. Analytical results showed that the cylindrical implant, is the most optimum shape among other types of implants.

植牙已经受到了很多关注，并已被用于治疗缺牙和坏牙等症状。由于患者的职业和年龄不同，植入物的功能和目的也不同。牙种植体的形状有很多种。然而，随着种植牙的普及，种植牙的形状给人们的眼睛带来了一些问题。事实上，有些植入物使用不当。这使得种植体周围的应力分布不合理;它不仅影响周围的骨吸收，而且会引起种植体的机械性骨折。本研究旨在评估五种不同种植体系统的力学特性。应用有限元等工程研究系统，对5种种植体及其周围骨组织在90N垂直载荷下进行建模和模拟。获得骨内应力和变形的分布并进行统计评分，用于判断种植体的最佳几何形状。分析结果表明，圆柱形种植体是所有种植体中最理想的形状。

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引用次数: 0

A Finite Element Based Comparative Study of Lumbosacral Pedicle Screw Fixation and Artificial Disc Replacement 基于有限元的腰骶椎弓根螺钉固定与人工椎间盘置换术的比较研究

Journal of engineering and science in medical diagnostics and therapy

Pub Date : 2023-02-24 DOI: 10.1115/1.4056953

J. Biswas, Anik Banerjee, N. Mondal, Masud Rana

The aim of this is to evaluate the biomechanical performance of double-level semi-rigid pedicle screw fixation and artificial intervertebral disc replacement in lumbar spine. Ti6Al4V and CFR-PEEK material are used for pedicle screw fixation and artificial disc replacement. In the present study, pedicle screw fixation and artificial intervertebral disc replacement are carried out between L3-L4-L5 regions under the application of moment 6,8,10 Nm and range of motion is compared during flexion, extension, and right-left lateral bending. Two level pedicle screw fusion and total disc replacement are developed in the L3-L4-L5 of the lumber spine vertebrae. Carbon fiber reinforced (CFR-PEEK) and Ultra High Molecular Weight Polyethylene (UHMWPE) are considered for the spinal fusion and the core part of the artificial disc respectively. Afterwards, applying the finite element analysis, it is detected that CFR-PEEK rod is able to increase range of motion at the implanted level in comparison to Ti6Al4V rod for both flexion-extension and lateral bending. In case of artificial intervertebral disc replacement hypermobility was observed. Hence, it is significant that rod material with CFR-PEEK is a better alternative for the treatment of degenerative diseases.

目的是评价双节段半刚性椎弓根螺钉固定和人工椎间盘置换术在腰椎的生物力学性能。Ti6Al4V和CFR-PEEK材料用于椎弓根螺钉固定和人工椎间盘置换术。在本研究中，在6、8、10 Nm的力矩下，在L3-L4-L5区域之间进行椎弓根螺钉固定和人工椎间盘置换术，并比较屈曲、伸展和左右侧向弯曲时的活动范围。在腰椎L3-L4-L5进行双节段椎弓根螺钉融合术和全椎间盘置换术。碳纤维增强材料(CFR-PEEK)和超高分子量聚乙烯(UHMWPE)分别用于脊柱融合和人工椎间盘核心部分。随后，应用有限元分析，检测到与Ti6Al4V棒相比，CFR-PEEK棒能够增加植入水平的屈伸和侧向弯曲的运动范围。在人工椎间盘置换术中观察到过度活动。因此，具有CFR-PEEK的棒材料是治疗退行性疾病的更好选择是很重要的。

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引用次数: 1

Evaluation of Resonance Frequency and Micro motion to achieve Implant Stability using Vibroacoustic RFA: A Mathematical Model 用振动声学RFA评估种植体稳定性的共振频率和微运动:一个数学模型

Journal of engineering and science in medical diagnostics and therapy

Pub Date : 2023-02-24 DOI: 10.1115/1.4056951

Vineet Khened, Kanad Dhok, M. Pradhan, P. Dhatrak

Dental implants are surgically implanted into the patient's jaw to replace a missing tooth. The implant should have adequate time to integrate with bone before being subjected to masticatory force to avoid early failure. Resonance Frequency Analysis (RFA) is one of the approaches for determining an implant system's primary stability in terms of micromotion. This research aims to create a two-degree of freedom (dof) mathematical model for dental prostheses based on the vibroacoustic RFA approach. In vibroacoustic system, a loudspeaker or buzzer is used as an input and the displacement of implant is measured using RFA. A sinusoidal force is used which produces a combination of translational and rotational motion of the implant system. While adjusting the input frequency from 4000 to 12000 Hz, is used with the help of MATLAB which later computes the implant system's subsequent micro-motion and resonance frequency. MATLAB is used to visualise the resonance frequency, which is 6658.38 Hz in case of rotational motion and 8138 Hz in translational motion. The micromotion was 1.2692 X 10-11 meters in case of translational motion and 6.91088 X 10-9 radians in case of rotational motion. When there is less micromotion, a higher resonance frequency suggests more excellent osseointegration. For the evaluation of implant stability, a mathematical model is a primary approach which can be implemented to design a stability device using vibroacoustic RFA.

植牙是通过外科手术将牙植入病人的下颌以代替缺牙。种植体在接受咀嚼力之前应有足够的时间与骨融合，以避免早期失效。共振频率分析(RFA)是确定植入体系统微动稳定性的方法之一。本研究旨在建立基于振动声学RFA方法的口腔修复体的二自由度数学模型。在振动声学系统中，使用扬声器或蜂鸣器作为输入，并使用RFA测量植入物的位移。使用正弦力产生植入体系统的平移和旋转运动的组合。在将输入频率从4000 Hz调整到12000 Hz的同时，借助MATLAB计算植入体系统的后续微运动和共振频率。利用MATLAB可视化了共振频率，旋转运动时为6658.38 Hz，平移运动时为8138 Hz。平移微运动为1.2692 X 10-11米，旋转微运动为6.91088 X 10-9弧度。微动越少，共振频率越高，骨整合越好。为了评估植入体的稳定性，数学模型是采用振动声RFA设计稳定装置的主要方法。

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引用次数: 0

Computational Fluid Dynamics Study of Particle Deposition On Human Lung Dynamic: A Comparison Between the Healthy and Fibrotic Lung 粒子沉积对人体肺动力学的计算流体动力学研究:健康肺与纤维化肺的比较

Journal of engineering and science in medical diagnostics and therapy

Pub Date : 2023-02-04 DOI: 10.1115/1.4056840

Carlo Carotenuto, L. Scurani, L. Fontanili, L. Montorsi, M. Milani

The lung is the human organ mainly affected by severe coronavirus disease (COVID-19) caused by the novel coronavirus SARS-CoV-2. In this pathology, the dynamic lung function and the respiratory mechanics are compromised, leading to the development of the ARDS (acute respiratory distress syndrome). The resulting damage is the progressive reduction of gas exchange and death in the most critical patients. For these reasons, it is important to study and analyze how this virus adversely affects lung dynamics. The main objective of the present paper is to propose a modeling methods of SARS-CoV-2 virus particles spread in the 23rd generation of lung tree and the mechanical estimation of how a severe stage of Covid-19 characterized by pulmonary fibrosis affects the alveolar sac expansion and hence the breathing capability of the sick person. In this context, the dynamic analysis of the influence of SARS-CoV-2 spread on human lung under real conditions has been shown by means of a numerical approach. Therefore, a multiphase three-dimensional computational fluid dynamics (CFD) study is performed to estimate the Covid-19 virus particles dispersion throughout a simplify model of the 23rd generation of bronchial tree, at the alveolar region. Then, a fully coupled fluid-structure interaction (FSI) with the mesh morphing technique and solid displacement characteristics are used to obtain and evaluate a realistic wall displacement during the expansion of the alveolar sac. A comparison is made between a healthy and a diseased lung. These phases are studied under cyclic steady-state conditions The novelties of this analysis are: firstly, the innovative CFD method proposed in order to model the particles spread inside the alveolar region, and secondly the evaluation of how the presence of Sars-Cov-2 can affect the mechanical properties of the alveolar sac and damage the lung function of a sick person at an advanced stage of infection, such as a person affected by pulmonary fibrosis.

肺是由新型冠状病毒SARS-CoV-2引起的严重冠状病毒病(COVID-19)主要影响的人体器官。在这种病理中，动态肺功能和呼吸力学受损，导致ARDS(急性呼吸窘迫综合征)的发展。由此造成的损害是气体交换的逐渐减少和最危重患者的死亡。由于这些原因，研究和分析这种病毒如何对肺动力学产生不利影响是很重要的。本文的主要目的是提出一种SARS-CoV-2病毒颗粒在第23代肺树中传播的建模方法，以及以肺纤维化为特征的Covid-19严重阶段如何影响肺泡囊扩张从而影响患者呼吸能力的机械估计。在此背景下，通过数值方法，对实际条件下SARS-CoV-2传播对人体肺部影响的动态分析。因此，通过多相三维计算流体动力学(CFD)研究估算了第23代支气管树的简化模型中Covid-19病毒颗粒在肺泡区域的分散情况。然后，结合网格变形技术和固体位移特性，采用完全耦合流固耦合(FSI)方法获得肺泡囊膨胀过程中真实的壁面位移。对健康的肺和患病的肺进行比较。该分析的新颖之处在于:首先，提出了创新的CFD方法，以模拟在肺泡区域内扩散的颗粒;其次，评估了Sars-Cov-2的存在如何影响感染晚期患者(例如肺纤维化患者)的肺泡囊的力学特性和肺功能的损害。

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引用次数: 0

Biaxial Tensile Prestress and Waveguide Effects on Estimates of the Complex Shear Modulus Using Optical-Based Dynamic Elastography in Plate-Like Soft Tissue Phantoms. 基于光学动态弹性成像的板状软组织幻影中复合剪切模量估算的双轴拉伸预应力和波导效应。

Journal of engineering and science in medical diagnostics and therapy

Pub Date : 2023-02-01 DOI: 10.1115/1.4056103

Marta Dore, Aime Luna, Thomas J Royston

Dynamic elastography attempts to reconstruct quantitative maps of the viscoelastic properties of biological tissue, properties altered by disease and injury, by noninvasively measuring mechanical wave motion in the tissue. Most reconstruction strategies that have been developed neglect boundary conditions, including quasi-static tensile or compressive loading resulting in a nonzero prestress. Significant prestress is inherent to the functional role of some biological tissues, such as skeletal and cardiac muscle, arterial walls, and the cornea. In the present article a novel configuration, inspired by corneal elastography but generalizable to other applications, is studied. A polymer phantom layer is statically elongated via an in-plane biaxial normal stress while the phantom's response to transverse vibratory excitation is measured. We examine the interplay between biaxial prestress and waveguide effects in this plate-like tissue phantom. Finite static deformations caused by prestressing coupled with waveguide effects lead to results that are predicted by a novel coordinate transformation approach previously used to simplify reconstruction of anisotropic properties. Here, the approach estimates material viscoelastic properties independent of the nonzero prestress conditions without requiring advanced knowledge of those stress conditions.

动态弹性成像试图通过无创测量组织中的机械波运动，重建生物组织粘弹性特性的定量图，这些特性因疾病和损伤而改变。大多数已经开发的重建策略忽略了边界条件，包括导致非零预应力的准静态拉伸或压缩加载。显著的预应力是固有的一些生物组织的功能作用，如骨骼肌和心肌，动脉壁和角膜。在本文中，研究了一种新的结构，灵感来自角膜弹性成像，但可推广到其他应用。通过平面内双轴法向应力静态拉伸聚合物模体层，同时测量了模体对横向振动激励的响应。我们研究了双轴预应力和波导效应之间的相互作用。预应力引起的有限静态变形与波导效应耦合导致的结果由一种新的坐标变换方法预测，该方法先前用于简化各向异性特性的重建。在这里，该方法估计材料的粘弹性特性独立于非零预应力条件，而不需要这些应力条件的先进知识。

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引用次数: 3