Journal of hazardous materials advances最新文献_第8页

Organochlorine pesticides in placenta, blood and breast milk of mothers in Uganda: Concentrations and health risks to breast fed infants 乌干达母亲胎盘、血液和母乳中的有机氯农药：浓度和对母乳喂养婴儿的健康风险

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-12-03 DOI: 10.1016/j.hazadv.2025.100949

Daniel Omoding , Teddy Nantume , John Wasswa , Silver Odongo , Christine Kyarimpa , Ibrahim Karume , Henry Matovu , Mika Sillanpää , Charles Drago Kato , Josephine Nabuuma , Ashirafu Miiro , Patrick Ssebugere

Exposure to organochlorine pesticides (OCPs) remains a major public health concern in low-income countries, where historical usage and poor regulation continue to result in maternal and early-life exposures. This study assessed concentration profiles of selected OCPs, namely; p,p′-DDT, p,p′-DDE, o,p′-DDE, p,p′-DDD, o,p′-DDD, aldrin, dieldrin, lindane, α-endosulfan, β-endosulfan, and endosulfan-sulfate in maternal blood, breast milk, and placenta samples collected from 52 healthy mothers residing in the rural Kanungu District and urban Kampala District in Uganda. Analytical quantification was performed using gas chromatography-electron capture detection (GC-ECD), and compound identity was confirmed by gas chromatography–mass spectrometry (GC-MS). Concentrations of total DDTs (∑DDTs) were 63.0, 27.1, and 35.0 ng g^-1 lipid weight (l.w) in blood, breast milk, and placenta, respectively. o,p′-DDE was the predominant metabolite in blood (67% of ∑DDTs), while p,p′-DDE dominated in placenta and milk (34% and 70%, respectively), possibly due to degradation of technical DDT applied in past decades. Other OCPs were generally low (<Limit of detection, LOD to 88.4 ng g^-1 l.w), except for dieldrin, which reached 130 ng g^-1 l.w in breast milk. OCP levels were significantly higher in Kanungu than Kampala, attributable to ongoing informal pesticide use in agriculture. In general, the estimated hazard quotients were <1, which indicated that the health risks posed to infants due to ingestion of OCPs in breast milk was negligible. Our findings underscore the need for rural pesticide regulation and continuous maternal exposure monitoring.

在低收入国家，接触有机氯农药仍然是一个主要的公共卫生问题，这些国家的历史使用和监管不力继续导致孕产妇和生命早期接触有机氯农药。本研究评估了所选ocp的浓度分布，即；对居住在乌干达卡农古农村地区和坎帕拉城市地区的52名健康母亲血液、母乳和胎盘样本中的p，p ' -滴滴涕、p，p ' -DDE、o,p ' -DDE、p,p ' -DDD、o,p ' -DDD、艾氏剂、狄氏剂、林丹、α-硫丹、β-硫丹和硫丹硫酸盐进行了研究。采用气相色谱-电子捕获检测（GC-ECD）进行分析定量，采用气相色谱-质谱（GC-MS）进行化合物鉴定。血液、母乳和胎盘中总DDTs（∑DDTs）浓度分别为63.0、27.1和35.0 ng g-1脂质重（l.w）。o，p′-DDE是血液中的主要代谢物（占∑DDTs的67%），而p，p′-DDE在胎盘和乳液中占主导地位（分别为34%和70%），可能是由于过去几十年使用的技术滴滴涕降解所致。其他ocp普遍较低（检出限，LOD为88.4 ng g-1 l.w），但狄氏剂在母乳中的检出限为130 ng g-1 l.w。卡农古的OCP水平明显高于坎帕拉，这是由于农业中持续非正式使用农药造成的。总的来说，估计的危害商数为<；1，这表明由于母乳中摄入ocp对婴儿造成的健康风险可以忽略不计。我们的研究结果强调了农村农药监管和持续监测孕产妇暴露的必要性。

{"title":"Organochlorine pesticides in placenta, blood and breast milk of mothers in Uganda: Concentrations and health risks to breast fed infants","authors":"Daniel Omoding , Teddy Nantume , John Wasswa , Silver Odongo , Christine Kyarimpa , Ibrahim Karume , Henry Matovu , Mika Sillanpää , Charles Drago Kato , Josephine Nabuuma , Ashirafu Miiro , Patrick Ssebugere","doi":"10.1016/j.hazadv.2025.100949","DOIUrl":"10.1016/j.hazadv.2025.100949","url":null,"abstract":"<div><div>Exposure to organochlorine pesticides (OCPs) remains a major public health concern in low-income countries, where historical usage and poor regulation continue to result in maternal and early-life exposures. This study assessed concentration profiles of selected OCPs, namely; <em>p,p′</em>-DDT, <em>p,p′</em>-DDE, <em>o,p′</em>-DDE, <em>p,p′</em>-DDD, <em>o,p′</em>-DDD, aldrin, dieldrin, lindane, α-endosulfan, β-endosulfan, and endosulfan-sulfate in maternal blood, breast milk, and placenta samples collected from 52 healthy mothers residing in the rural Kanungu District and urban Kampala District in Uganda. Analytical quantification was performed using gas chromatography-electron capture detection (GC-ECD), and compound identity was confirmed by gas chromatography–mass spectrometry (GC-MS). Concentrations of total DDTs (∑DDTs) were 63.0, 27.1, and 35.0 ng g<sup>-1</sup> lipid weight (l.w) in blood, breast milk, and placenta, respectively. <em>o,p′</em>-DDE was the predominant metabolite in blood (67% of ∑DDTs), while <em>p,p′</em>-DDE dominated in placenta and milk (34% and 70%, respectively), possibly due to degradation of technical DDT applied in past decades. Other OCPs were generally low (<Limit of detection, LOD to 88.4 ng g<sup>-1</sup> l.w), except for dieldrin, which reached 130 ng g<sup>-1</sup> l.w in breast milk. OCP levels were significantly higher in Kanungu than Kampala, attributable to ongoing informal pesticide use in agriculture. In general, the estimated hazard quotients were <1, which indicated that the health risks posed to infants due to ingestion of OCPs in breast milk was negligible. Our findings underscore the need for rural pesticide regulation and continuous maternal exposure monitoring.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100949"},"PeriodicalIF":7.7,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145685539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotic residues in farmed fish and sediments from cage aquaculture: Insights from Stratum II of the Volta Lake, Ghana 养殖鱼类和网箱养殖沉积物中的抗生素残留：来自加纳Volta湖第二层的见解

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-12-02 DOI: 10.1016/j.hazadv.2025.100961

Samuel O. Dandi , Øystein Evensen , Samuel Addo , Emmanuel D. Abarike , Seth M. Abobi , Dzigbodi A. Doke , Jan L. Lyche , Stephen Mutoloki , Amii I. Obiakara-Amaechi , Elliot H. Alhassan , Kofitsyo S. Cudjoe , Regina E. Edziyie , Samuel Opokuware

<div><h3>Introduction</h3><div>Antibiotics are commonly used to treat infections and promote fish welfare in Aquaculture. Reports suggest that the use of antibiotics in fish farming often breaches established protocols, frequently accumulating in fish muscles and sediments. These residues are known to be detrimental to the fish, altering antioxidant activity and immune responses, and posing environmental risks. In this study, we aimed to investigate the presence, types and quantify, quantify the levels of antibiotic and residues in Nila tilapia (<em>Oreochromis niloticus</em>) fish muscles and sediment samples, and evaluate the associated health risks to humans and the aquatic ecosystem in Stratum II of Lake Volta, Ghana.</div></div><div><h3>Methodology</h3><div>Muscles of table-sized fish and sediment samples were collected from cage aquaculture farms along the Stratum II of the Lake Volta, Ghana, and analysed using Liquid Chromatography with tandem mass spectrometry (LC-MS-MS) for the presence of antibiotic residues. Variations in residual antibiotic concentrations and basic sediment properties throughout the various strata of the Lake Volta were examined using analysis of variance (ANOVA) with a general linear model (GLM). A post-hoc test for multiple comparisons with a significance level of <em>p</em> < 0.05 was performed using Tukey's HSD technique. Potential antibiotic sources were examined using principal component analysis (PCA). Possible risks to human health and the environment were estimated using risk quotients described in the European Technical Guidance Document on Risk Assessment.</div></div><div><h3>Results</h3><div>Four antibiotics, namely ciprofloxacin, tetracycline, chloramphenicol, and azithromycin, were identified in both fish muscle and sediments, with Azithromycin, tetracycline, and ciprofloxacin residues being the most frequently detected antibiotics. Except ciprofloxacin which showed higher concentration midstream, the rest showed higher concentrations of the detected antibiotic residues from downstream sites. Risk analysis of antibiotic residues in fish muscle tissues and sediments revealed risk quotients that ranged from 0.0024–0.0382 for humans and from 0.0200 – 0.5713 for the aquatic ecosystem in the Lake.</div></div><div><h3>Discussion and conclusion</h3><div>The detection of antibiotic residues in both fish muscle and sediment from aquaculture farms along Lake Volta suggests evidence of antibiotic use or contamination in fish farming in the Lake Volta. Though current antibiotic levels may not pose immediate risks, their accumulation, particularly Chloramphenicol, which has been banned for use in aquaculture, could contribute to antimicrobial resistance making it difficult for future treatment of human infection as well as compromising the food quality and safety. Antibiotic residues in fish and sediments from Lake Volta aquaculture signal contamination risks and a potential threat to future infection treatment</d

在水产养殖中，抗生素通常用于治疗感染和促进鱼类福利。报告显示，在鱼类养殖中使用抗生素经常违反既定的规程，经常积聚在鱼类肌肉和沉积物中。已知这些残留物对鱼类有害，改变抗氧化活性和免疫反应，并构成环境风险。在这项研究中，我们旨在调查尼拉罗非鱼（Oreochromis niloticus）鱼肌肉和沉积物样本中抗生素和残留物的存在、类型和量化，并评估加纳沃尔塔湖第二层对人类和水生生态系统的相关健康风险。方法：从加纳Volta湖第II层的网箱养殖农场收集鱼的肌肉和沉积物样本，并使用液相色谱-串联质谱（LC-MS-MS）分析抗生素残留的存在。利用一般线性模型（GLM）进行方差分析（ANOVA），研究了Volta湖不同地层中残留抗生素浓度和基本沉积物性质的变化。采用Tukey’s HSD技术对多重比较进行事后检验，显著性水平为p <； 0.05。使用主成分分析（PCA）检查潜在的抗生素来源。使用《欧洲风险评估技术指导文件》中描述的风险商数对人类健康和环境可能面临的风险进行了估计。结果在鱼类肌肉和沉积物中检出环丙沙星、四环素、氯霉素和阿奇霉素4种抗生素残留，其中阿奇霉素、四环素和环丙沙星是检出最多的抗生素残留。除环丙沙星中游浓度较高外，其余抗生素残留量均在下游。鱼类肌肉组织和沉积物中抗生素残留的风险分析显示，人类的风险商数为0.0024 ~ 0.0382，湖泊水生生态系统的风险商数为0.0200 ~ 0.5713。讨论与结论在Volta湖沿岸养殖场的鱼肌肉和沉积物中都检测到抗生素残留，这表明Volta湖的养鱼场使用了抗生素或受到了污染。虽然目前的抗生素水平可能不会立即构成风险，但它们的积累，特别是已被禁止在水产养殖中使用的氯霉素，可能会导致抗菌素耐药性，使未来治疗人类感染变得困难，并危及食品质量和安全。来自Volta湖水产养殖的鱼类和沉积物中的抗生素残留表明污染风险和对未来感染治疗的潜在威胁

{"title":"Antibiotic residues in farmed fish and sediments from cage aquaculture: Insights from Stratum II of the Volta Lake, Ghana","authors":"Samuel O. Dandi , Øystein Evensen , Samuel Addo , Emmanuel D. Abarike , Seth M. Abobi , Dzigbodi A. Doke , Jan L. Lyche , Stephen Mutoloki , Amii I. Obiakara-Amaechi , Elliot H. Alhassan , Kofitsyo S. Cudjoe , Regina E. Edziyie , Samuel Opokuware","doi":"10.1016/j.hazadv.2025.100961","DOIUrl":"10.1016/j.hazadv.2025.100961","url":null,"abstract":"<div><h3>Introduction</h3><div>Antibiotics are commonly used to treat infections and promote fish welfare in Aquaculture. Reports suggest that the use of antibiotics in fish farming often breaches established protocols, frequently accumulating in fish muscles and sediments. These residues are known to be detrimental to the fish, altering antioxidant activity and immune responses, and posing environmental risks. In this study, we aimed to investigate the presence, types and quantify, quantify the levels of antibiotic and residues in Nila tilapia (<em>Oreochromis niloticus</em>) fish muscles and sediment samples, and evaluate the associated health risks to humans and the aquatic ecosystem in Stratum II of Lake Volta, Ghana.</div></div><div><h3>Methodology</h3><div>Muscles of table-sized fish and sediment samples were collected from cage aquaculture farms along the Stratum II of the Lake Volta, Ghana, and analysed using Liquid Chromatography with tandem mass spectrometry (LC-MS-MS) for the presence of antibiotic residues. Variations in residual antibiotic concentrations and basic sediment properties throughout the various strata of the Lake Volta were examined using analysis of variance (ANOVA) with a general linear model (GLM). A post-hoc test for multiple comparisons with a significance level of <em>p</em> < 0.05 was performed using Tukey's HSD technique. Potential antibiotic sources were examined using principal component analysis (PCA). Possible risks to human health and the environment were estimated using risk quotients described in the European Technical Guidance Document on Risk Assessment.</div></div><div><h3>Results</h3><div>Four antibiotics, namely ciprofloxacin, tetracycline, chloramphenicol, and azithromycin, were identified in both fish muscle and sediments, with Azithromycin, tetracycline, and ciprofloxacin residues being the most frequently detected antibiotics. Except ciprofloxacin which showed higher concentration midstream, the rest showed higher concentrations of the detected antibiotic residues from downstream sites. Risk analysis of antibiotic residues in fish muscle tissues and sediments revealed risk quotients that ranged from 0.0024–0.0382 for humans and from 0.0200 – 0.5713 for the aquatic ecosystem in the Lake.</div></div><div><h3>Discussion and conclusion</h3><div>The detection of antibiotic residues in both fish muscle and sediment from aquaculture farms along Lake Volta suggests evidence of antibiotic use or contamination in fish farming in the Lake Volta. Though current antibiotic levels may not pose immediate risks, their accumulation, particularly Chloramphenicol, which has been banned for use in aquaculture, could contribute to antimicrobial resistance making it difficult for future treatment of human infection as well as compromising the food quality and safety. Antibiotic residues in fish and sediments from Lake Volta aquaculture signal contamination risks and a potential threat to future infection treatment</d","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100961"},"PeriodicalIF":7.7,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep learning-based screening of zebrafish embryo malformations for assessing the developmental toxicity and EC50 estimation of disinfection by-products 基于深度学习的斑马鱼胚胎畸形筛选及其消毒副产物的发育毒性评估和EC50估计

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-12-01 DOI: 10.1016/j.hazadv.2025.100960

Yizhi Pei , Chunxu Chen , Kongyan Luo , Junmin Gao , Haifeng Zhang

Chlorine disinfection of drinking water has widely led to the formation of carcinogenic and teratogenic halogenated disinfection by-products, but only a small fraction of them have been identified and undergone systematic toxicological evaluation. In this study, a high-throughput toxicity screening strategy that integrates a computer vision-based model with the zebrafish embryo assay was presented. This framework enables automated identification of teratogenic morphological endpoints from embryo images and facilitates subsequent dose–response analysis for toxicological metrics. Four DBPs (trichloroacetaldehyde, dichloroacetaldehyde, chloroacetaldehyde and tribromoacetaldehyde) were selected for acute exposure. An annotated zebrafish deformity image dataset with literature images and 609 in house images were curated. Channel Attention and Multi-scale Detection module were incorporated into the neural network architecture to improve detection performance. The optimized model demonstrated high classification accuracy across diverse malformation types (mAP50 = 0.873), with strong precision and recall metricsand EC₅₀ values calculated by the model were highly consistent with those obtained manually. Beyond high-throughput screening, this framework could bridge computer vision with the Adverse Outcome Pathway (AOP) concept, as AI-recognized malformations correspond to key developmental events related to cardiotoxicity and metabolic disruption in the future. This integration enhances the mechanistic interpretability and predictive capacity of AI-based toxicity evaluation, providing a scalable tool for zebrafish-based chemical screening and environmental risk assessment.

饮用水氯消毒广泛导致致癌性、致畸性卤化消毒副产物的形成，但目前仅有一小部分得到了鉴定并进行了系统的毒理学评价。在这项研究中，提出了一种高通量毒性筛选策略，该策略将基于计算机视觉的模型与斑马鱼胚胎测定相结合。该框架能够从胚胎图像中自动识别致畸形态学端点，并促进随后的毒理学指标剂量反应分析。四种dbp（三氯乙醛，二氯乙醛，氯乙醛和三溴乙醛）被选择急性暴露。整理了一个带注释的斑马鱼畸形图像数据集，包括文献图像和609张室内图像。在神经网络结构中加入了通道关注和多尺度检测模块，提高了检测性能。优化后的模型在不同的畸形类型中具有较高的分类准确率（mAP50 = 0.873），具有较强的精度和召回率指标，且模型计算的EC50值与人工获得的EC50值高度一致。除了高通量筛选之外，该框架还可以将计算机视觉与不良结果途径（AOP）概念联系起来，因为人工智能识别的畸形对应于未来与心脏毒性和代谢中断相关的关键发育事件。这种整合增强了基于人工智能的毒性评估的机制可解释性和预测能力，为基于斑马鱼的化学筛选和环境风险评估提供了可扩展的工具。

{"title":"Deep learning-based screening of zebrafish embryo malformations for assessing the developmental toxicity and EC50 estimation of disinfection by-products","authors":"Yizhi Pei , Chunxu Chen , Kongyan Luo , Junmin Gao , Haifeng Zhang","doi":"10.1016/j.hazadv.2025.100960","DOIUrl":"10.1016/j.hazadv.2025.100960","url":null,"abstract":"<div><div>Chlorine disinfection of drinking water has widely led to the formation of carcinogenic and teratogenic halogenated disinfection by-products, but only a small fraction of them have been identified and undergone systematic toxicological evaluation. In this study, a high-throughput toxicity screening strategy that integrates a computer vision-based model with the zebrafish embryo assay was presented. This framework enables automated identification of teratogenic morphological endpoints from embryo images and facilitates subsequent dose–response analysis for toxicological metrics. Four DBPs (trichloroacetaldehyde, dichloroacetaldehyde, chloroacetaldehyde and tribromoacetaldehyde) were selected for acute exposure. An annotated zebrafish deformity image dataset with literature images and 609 in house images were curated. Channel Attention and Multi-scale Detection module were incorporated into the neural network architecture to improve detection performance. The optimized model demonstrated high classification accuracy across diverse malformation types (mAP50 = 0.873), with strong precision and recall metricsand EC<sub>50</sub> values calculated by the model were highly consistent with those obtained manually. Beyond high-throughput screening, this framework could bridge computer vision with the Adverse Outcome Pathway (AOP) concept, as AI-recognized malformations correspond to key developmental events related to cardiotoxicity and metabolic disruption in the future. This integration enhances the mechanistic interpretability and predictive capacity of AI-based toxicity evaluation, providing a scalable tool for zebrafish-based chemical screening and environmental risk assessment.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100960"},"PeriodicalIF":7.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of long-term exposure to ambient PM2.5 mass and its chemical components in the trajectory of chronic disease multimorbidity: Evidence from a large longitudinal study 长期暴露于环境PM2.5质量及其化学成分在慢性病多发病轨迹中的作用：来自大型纵向研究的证据

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-30 DOI: 10.1016/j.hazadv.2025.100959

Xinjie Xiao , Wei Wu , Juanjuan Zhang , Qijiong Zhu , Yilin Li , Yayi Li , Haoyi Feng , Wan Peng , Jianxiong Hu , Dan Cai , Hongwei Tu , Guanhao He , Wenjun Ma , Tao Liu

Against the backdrop of global aging, rising risks of chronic diseases and multimorbidity pose considerable public health challenges. To investigate the association of long-term exposure to fine particulate matter (PM_2.5) and its chemical components with multimorbidity development, this prospective cohort study included 8,257 participants from the China Health and Retirement Longitudinal Study (CHARLS) cohort (2011–2020). PM_2.5 mass and its chemical components (sulfate [SO₄^2-], nitrate [NO₃^-], ammonium [NH₄⁺], organic matter [OM], and black carbon [BC]) were evaluated by city-level three-year average exposures. Multistate models were used to estimate the hazard ratios (HRs) for chronic disease accumulation and death, and the corresponding population-attributable fractions (PAFs) attributable to PM_2.5 mass and its chemical components were also calculated. For single chronic disease patients, each standard deviation (SD = 14.2 μg/m³) increase in PM_2.5 mass concentration was associated with HRs of 1.46 and 2.14 for basic multimorbidity and death, respectively. Among those with basic multimorbidity, each SD increase yielded HRs of 1.31 for complex multimorbidity and 2.20 for death. BC showed the strongest association with multimorbidity development, followed by SO₄^2-, OM, NH₄⁺, and NO₃^-. Achieving China's Grade II PM_2.5 standard (35 μg/m³) could avert 19.32% of transitions from one disease to basic multimorbidity and 13.86% of transitions from basic to complex multimorbidity. Long-term exposure to PM_2.5 mass and its chemical components was associated with increased risks across all disease stages of multimorbidity development. Targeted air pollution control, especially BC reduction, is crucial to mitigate associated health burdens.

在全球老龄化的背景下，慢性病和多病风险的上升构成了相当大的公共卫生挑战。为了研究长期暴露于细颗粒物（PM2.5）及其化学成分与多种疾病发展的关系，本前瞻性队列研究纳入了来自中国健康与退休纵向研究（CHARLS）队列（2011-2020）的8,257名参与者。PM2.5质量及其化学成分（硫酸盐[SO42-]、硝酸盐[NO3-]、铵态氮[NH4+]、有机质[OM]和黑碳[BC]）采用城市3年平均暴露量评价。采用多状态模型估算慢性疾病积累和死亡的风险比（hr），并计算PM2.5质量及其化学成分对应的人群归因分数（paf）。对于单一慢性疾病患者，PM2.5质量浓度每增加一个标准差（SD = 14.2 μg/m³），基本多发病和死亡的hr分别为1.46和2.14。在基本多发病的患者中，每增加一个SD，复杂多发病的hr为1.31，死亡的hr为2.20。BC与多种疾病发展的相关性最强，其次是SO42-、OM、NH4+和NO3-。达到中国PM2.5二级标准（35 μg/m³）可以避免19.32%的疾病从一种疾病向基本多病过渡，13.86%的疾病从基本多病向复杂多病过渡。长期暴露于PM2.5质量及其化学成分与多病发展的所有疾病阶段的风险增加有关。有针对性的空气污染控制，特别是减少BC，对于减轻相关的健康负担至关重要。

{"title":"Roles of long-term exposure to ambient PM2.5 mass and its chemical components in the trajectory of chronic disease multimorbidity: Evidence from a large longitudinal study","authors":"Xinjie Xiao , Wei Wu , Juanjuan Zhang , Qijiong Zhu , Yilin Li , Yayi Li , Haoyi Feng , Wan Peng , Jianxiong Hu , Dan Cai , Hongwei Tu , Guanhao He , Wenjun Ma , Tao Liu","doi":"10.1016/j.hazadv.2025.100959","DOIUrl":"10.1016/j.hazadv.2025.100959","url":null,"abstract":"<div><div>Against the backdrop of global aging, rising risks of chronic diseases and multimorbidity pose considerable public health challenges. To investigate the association of long-term exposure to fine particulate matter (PM<sub>2.5</sub>) and its chemical components with multimorbidity development, this prospective cohort study included 8,257 participants from the China Health and Retirement Longitudinal Study (CHARLS) cohort (2011–2020). PM<sub>2.5</sub> mass and its chemical components (sulfate [SO<sub>4</sub><sup>2-</sup>], nitrate [NO<sub>3</sub><sup>-</sup>], ammonium [NH<sub>4</sub><sup>+</sup>], organic matter [OM], and black carbon [BC]) were evaluated by city-level three-year average exposures. Multistate models were used to estimate the hazard ratios (HRs) for chronic disease accumulation and death, and the corresponding population-attributable fractions (PAFs) attributable to PM<sub>2.5</sub> mass and its chemical components were also calculated. For single chronic disease patients, each standard deviation (SD = 14.2 μg/m³) increase in PM<sub>2.5</sub> mass concentration was associated with HRs of 1.46 and 2.14 for basic multimorbidity and death, respectively. Among those with basic multimorbidity, each SD increase yielded HRs of 1.31 for complex multimorbidity and 2.20 for death. BC showed the strongest association with multimorbidity development, followed by SO<sub>4</sub><sup>2-</sup>, OM, NH<sub>4</sub><sup>+</sup>, and NO<sub>3</sub><sup>-</sup>. Achieving China's Grade II PM<sub>2.5</sub> standard (35 μg/m³) could avert 19.32% of transitions from one disease to basic multimorbidity and 13.86% of transitions from basic to complex multimorbidity. Long-term exposure to PM<sub>2.5</sub> mass and its chemical components was associated with increased risks across all disease stages of multimorbidity development. Targeted air pollution control, especially BC reduction, is crucial to mitigate associated health burdens.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100959"},"PeriodicalIF":7.7,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145685540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies for the development of antifouling membranes for liquid filtration: A review 液体过滤用防污膜的研究进展

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-29 DOI: 10.1016/j.hazadv.2025.100958

Nasrul Arahman , Nafiu Umar Barambu , Mohammad Roil Bilad , Sri Mulyati , Cut Meurah Rosnelly , Sri Aprilia

Membrane technology has been embraced as the best technology for process separation and purification by virtue of its economic and environmental advantages. The performance of membrane technology is assessed by its selectivity and hydraulic output, which are challenged by membrane fouling. Membrane fouling encourages hydraulic resistance and retarded the selectivity of the membrane. Therefore, membrane fouling is the prime downside of membrane technology and it can be modulated by developing the membrane surface chemistry and/or the filtration system hydrodynamics. Membrane surface chemistry and filtration system hydrodynamics development for membrane fouling control have been intensively explored and many concepts are emerging day by day. Therefore, its paramount to review the performance of the emerging concepts and develop a roadmap for exploration of new concepts. This manuscript reviews the recent advances in membrane surface chemistry and filtration system hydrodynamics development for membrane fouling control in liquid filtration. The focus is mainly on the mechanisms and limitations of membrane surface chemistry and filtration system hydrodynamics development for membrane fouling mitigation. Moreover, the manuscript also outlined the future perspectives of membrane surface chemistry and filtration system hydrodynamics development for optimum membrane fouling control.

膜技术以其经济、环保的优点，已被公认为工艺分离净化的最佳技术。膜技术的性能是通过其选择性和水力输出来评价的，这是膜污染所面临的挑战。膜污染增加了膜的水力阻力，降低了膜的选择性。因此，膜污染是膜技术的主要缺点，它可以通过发展膜表面化学和/或过滤系统的水动力学来调节。膜表面化学和过滤系统水动力学在膜污染控制方面的发展得到了深入的探索，许多概念日益涌现。因此，审查新兴概念的性能并为探索新概念制定路线图是至关重要的。本文综述了膜表面化学和过滤系统流体力学在液体过滤中膜污染控制方面的研究进展。重点介绍了膜表面化学和过滤系统水动力学在膜污染防治中的作用机理和局限性。此外，本文还概述了膜表面化学和过滤系统水动力学发展的未来前景，以实现最佳的膜污染控制。

{"title":"Strategies for the development of antifouling membranes for liquid filtration: A review","authors":"Nasrul Arahman , Nafiu Umar Barambu , Mohammad Roil Bilad , Sri Mulyati , Cut Meurah Rosnelly , Sri Aprilia","doi":"10.1016/j.hazadv.2025.100958","DOIUrl":"10.1016/j.hazadv.2025.100958","url":null,"abstract":"<div><div>Membrane technology has been embraced as the best technology for process separation and purification by virtue of its economic and environmental advantages. The performance of membrane technology is assessed by its selectivity and hydraulic output, which are challenged by membrane fouling. Membrane fouling encourages hydraulic resistance and retarded the selectivity of the membrane. Therefore, membrane fouling is the prime downside of membrane technology and it can be modulated by developing the membrane surface chemistry and/or the filtration system hydrodynamics. Membrane surface chemistry and filtration system hydrodynamics development for membrane fouling control have been intensively explored and many concepts are emerging day by day. Therefore, its paramount to review the performance of the emerging concepts and develop a roadmap for exploration of new concepts. This manuscript reviews the recent advances in membrane surface chemistry and filtration system hydrodynamics development for membrane fouling control in liquid filtration. The focus is mainly on the mechanisms and limitations of membrane surface chemistry and filtration system hydrodynamics development for membrane fouling mitigation. Moreover, the manuscript also outlined the future perspectives of membrane surface chemistry and filtration system hydrodynamics development for optimum membrane fouling control.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100958"},"PeriodicalIF":7.7,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nature’s Cleanup Crew: Algal–Bacterial Partnerships in Heavy Metal-Polluted Waters 大自然的清理人员：重金属污染水域中的藻类-细菌伙伴关系

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-28 DOI: 10.1016/j.hazadv.2025.100957

Asra Fadaeipour , Noreen Ashraf , Ammad Abbas , Assemgul K. Sadvakasova , Mostafa E. Elshobary , Amina Khalid , Da-Chuan Yin , Fiaz Ahmad

The escalating accumulation and dissemination of heavy metals (HMs) in the environmental matrices present growing ecological and public health concerns, underscoring the significance of natural process mediating their removal from environment. Among emerging biotechnological approaches, microalgae–bacteria consortia have garnered significant attention as naturally occurring, sustainable systems for the remediation of HMs and organic pollutants in industrial and municipal wastewaters. Despite their promise, the underlying mechanisms that govern microalgae–bacteria interactions, particularly under stress from emerging pollutants and during HM removal remain inadequately understood. Two primary modes of interaction, physical associations and molecular-level communications, are fundamental to their co-adaptation, survival, and functional synergy. These interactions encompass extracellular and intracellular processes such as chemotaxis, quorum sensing, transcriptomic reprogramming, and genetic adaptation. This review synthesizes current knowledge on the dynamic interplay within microalgae–bacteria systems, emphasizing their mechanistic roles in metal sequestration. We presented recent advancements to deepen our understanding of these interactions and support the development of efficient and sustainable biotechnologies for environmental remediation and resource recovery.

重金属在环境基质中的积累和传播不断升级，引起了越来越多的生态和公共卫生问题，强调了自然过程介导其从环境中移除的重要性。在新兴的生物技术方法中，微藻-细菌联合体作为一种自然发生的、可持续的系统，已经引起了人们的极大关注，用于修复工业和城市废水中的HMs和有机污染物。尽管它们很有前景，但控制微藻-细菌相互作用的潜在机制，特别是在新出现的污染物和HM去除过程中的压力下，仍然没有得到充分的了解。两种主要的相互作用模式，物理关联和分子水平的通信，是它们共同适应、生存和功能协同的基础。这些相互作用包括细胞外和细胞内的过程，如趋化性、群体感应、转录组重编程和遗传适应。本文综述了目前关于微藻-细菌系统内动态相互作用的知识，强调了它们在金属隔离中的机制作用。我们介绍了最近的进展，以加深我们对这些相互作用的理解，并支持开发高效和可持续的生物技术用于环境修复和资源恢复。

{"title":"Nature’s Cleanup Crew: Algal–Bacterial Partnerships in Heavy Metal-Polluted Waters","authors":"Asra Fadaeipour , Noreen Ashraf , Ammad Abbas , Assemgul K. Sadvakasova , Mostafa E. Elshobary , Amina Khalid , Da-Chuan Yin , Fiaz Ahmad","doi":"10.1016/j.hazadv.2025.100957","DOIUrl":"10.1016/j.hazadv.2025.100957","url":null,"abstract":"<div><div>The escalating accumulation and dissemination of heavy metals (HMs) in the environmental matrices present growing ecological and public health concerns, underscoring the significance of natural process mediating their removal from environment. Among emerging biotechnological approaches, microalgae–bacteria consortia have garnered significant attention as naturally occurring, sustainable systems for the remediation of HMs and organic pollutants in industrial and municipal wastewaters. Despite their promise, the underlying mechanisms that govern microalgae–bacteria interactions, particularly under stress from emerging pollutants and during HM removal remain inadequately understood. Two primary modes of interaction, physical associations and molecular-level communications, are fundamental to their co-adaptation, survival, and functional synergy. These interactions encompass extracellular and intracellular processes such as chemotaxis, quorum sensing, transcriptomic reprogramming, and genetic adaptation. This review synthesizes current knowledge on the dynamic interplay within microalgae–bacteria systems, emphasizing their mechanistic roles in metal sequestration. We presented recent advancements to deepen our understanding of these interactions and support the development of efficient and sustainable biotechnologies for environmental remediation and resource recovery.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100957"},"PeriodicalIF":7.7,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First evidence of CuPANotic cell death in fish gut upon environmentally relevant co-exposure to Copper and PVC microplastics 在环境相关的铜和聚氯乙烯微塑料共同暴露下，鱼类肠道中CuPANotic细胞死亡的第一个证据

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-28 DOI: 10.1016/j.hazadv.2025.100956

Jumman Bakhasha , Vaishnavi Saxena , Neeti Arya , Pradeep Kumar , Kamlesh K. Yadav , Dana Kühnel , Abha Trivedi

Microplastic-metal interactions represent a critical but underexplored dimension of aquatic ecotoxicology. Here, we provide the first validation of a novel CuPANoptosis (Cuproptosis and PANoptosis) paradigm in fish, uncovering how polyvinyl chloride microplastics (PVC-MPs) intensifies copper (Cu²⁺)-induced toxicity in Channa punctatus. Fish were exposed to environmentally relevant concentrations of PVC-MPs (0.5 mg/L) and copper (0.85 mg/L), individually and in combination, for 60 days. PVC-MPs acted as potent vectors, enhancing copper bioavailability, tissue retention, and translocation across intestinal barriers, resulting in exacerbated oxidative stress and mitochondrial dysfunction. Mechanistically, FDX1-mediated Cu⁺ reduction accelerated abnormal protein lipoylation and aggregation, collapsing TCA cycle function and triggering cuproptosis. Strikingly, this cuproptotic activation integrated with apoptotic, pyroptotic, and necroptotic pathways, forming an interconnected programmed cell death circuitry ‘CuPANoptosis’. The co-exposure group exhibited maximal ROS accumulation, lipid peroxidation, GSH depletion, and severe disruption of intestinal architecture, including vacuolization, villi detachment, and widespread cellular damage, with all key alterations showing high statistical significance (p < 0.05). Transcriptional and protein-level analyses revealed upregulation of key mediators including fdx1, dlat, dlst, bax, nlrp3, ripk1, and caspases, validating synchronized activation of multiple cell death pathways. These findings highlight that PVC-MPs act as dynamic carriers amplifying copper-induced toxicity and unveil a previously unrecognized mechanism of gut injury. Collectively, our study provides the first transformative framework for understanding MP-metal synergy in aquatic systems, emphasizing urgent ecological risks and the need for targeted mitigation strategies.

微塑料与金属的相互作用是水生生态毒理学中一个关键但未被充分探索的方面。在这里，我们首次在鱼类中验证了一种新的CuPANoptosis （cuprotosis和PANoptosis）模式，揭示了聚氯乙烯微塑料（PVC-MPs）如何增强铜（Cu 2 +）在斑鳉鱼中诱导的毒性。鱼分别或同时暴露于环境相关浓度的PVC-MPs （0.5 mg/L）和铜（0.85 mg/L）中60天。PVC-MPs作为有效载体，增强了铜的生物利用度、组织保留和跨肠屏障的易位，从而加剧了氧化应激和线粒体功能障碍。机制上，fdx1介导的Cu⁺还原加速了异常蛋白脂酰化和聚集，破坏了TCA循环功能，引发铜还原。引人注目的是，这种铜细胞凋亡激活与凋亡、焦亡和坏死途径结合在一起，形成了一个相互关联的程序性细胞死亡回路“铜细胞凋亡”。共暴露组表现出最大的ROS积累、脂质过氧化、谷胱甘肽耗损以及肠道结构的严重破坏，包括空泡化、绒毛脱落和广泛的细胞损伤，所有关键改变均具有高度统计学意义（p < 0.05）。转录和蛋白水平分析显示，fdx1、dlat、dlst、bax、nlrp3、ripk1和caspases等关键介质上调，证实了多种细胞死亡途径的同步激活。这些发现强调PVC-MPs作为动态载体放大铜诱导的毒性，并揭示了以前未被认识的肠道损伤机制。总的来说，我们的研究为理解水生系统中的mp -金属协同作用提供了第一个变革性框架，强调了紧迫的生态风险和有针对性的缓解战略的必要性。

{"title":"First evidence of CuPANotic cell death in fish gut upon environmentally relevant co-exposure to Copper and PVC microplastics","authors":"Jumman Bakhasha , Vaishnavi Saxena , Neeti Arya , Pradeep Kumar , Kamlesh K. Yadav , Dana Kühnel , Abha Trivedi","doi":"10.1016/j.hazadv.2025.100956","DOIUrl":"10.1016/j.hazadv.2025.100956","url":null,"abstract":"<div><div>Microplastic-metal interactions represent a critical but underexplored dimension of aquatic ecotoxicology. Here, we provide the first validation of a novel CuPANoptosis (Cuproptosis and PANoptosis) paradigm in fish, uncovering how polyvinyl chloride microplastics (PVC-MPs) intensifies copper (Cu²⁺)-induced toxicity in <em>Channa punctatus</em>. Fish were exposed to environmentally relevant concentrations of PVC-MPs (0.5 mg/L) and copper (0.85 mg/L), individually and in combination, for 60 days. PVC-MPs acted as potent vectors, enhancing copper bioavailability, tissue retention, and translocation across intestinal barriers, resulting in exacerbated oxidative stress and mitochondrial dysfunction. Mechanistically, FDX1-mediated Cu⁺ reduction accelerated abnormal protein lipoylation and aggregation, collapsing TCA cycle function and triggering cuproptosis. Strikingly, this cuproptotic activation integrated with apoptotic, pyroptotic, and necroptotic pathways, forming an interconnected programmed cell death circuitry ‘CuPANoptosis’. The co-exposure group exhibited maximal ROS accumulation, lipid peroxidation, GSH depletion, and severe disruption of intestinal architecture, including vacuolization, villi detachment, and widespread cellular damage, with all key alterations showing high statistical significance (<em>p <</em> 0.05)<strong>.</strong> Transcriptional and protein-level analyses revealed upregulation of key mediators including <em>fdx1, dlat, dlst, bax, nlrp3, ripk1</em>, and <em>caspases</em>, validating synchronized activation of multiple cell death pathways. These findings highlight that PVC-MPs act as dynamic carriers amplifying copper-induced toxicity and unveil a previously unrecognized mechanism of gut injury. Collectively, our study provides the first transformative framework for understanding MP-metal synergy in aquatic systems, emphasizing urgent ecological risks and the need for targeted mitigation strategies.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100956"},"PeriodicalIF":7.7,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145737452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary phthalate metabolites and central precocious puberty in girls: Evidence for luteinizing hormone mediation 女孩尿邻苯二甲酸酯代谢物和中枢性性早熟：黄体生成素介导的证据

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-28 DOI: 10.1016/j.hazadv.2025.100955

Iman Al-Saleh , Rola Elkhatib , Afaf Alsagheir , Habiba Sultana , Khalid Alhusayn , Saleh Aldgither , Syed N Alvi , Yara Aljerayed , Mawadah Baali , Edward Devol

There is growing concern that endocrine-disrupting chemicals (EDCs) may contribute to the rising incidence of central precocious puberty (CPP). This case-control study examined whether urinary concentrations of phthalate metabolites and bisphenol A (BPA) are associated with CPP risk. We recruited 77 girls (20 with idiopathic CPP and 57 age-matched controls) between 2021 and 2025 from a tertiary hospital in Saudi Arabia. Urinary EDCs were quantified using ultra-performance liquid chromatography–tandem mass spectrometry, and serum reproductive hormones, including luteinizing hormone (LH), follicle-stimulating hormone, estradiol, and cortisol, were assessed. Although urinary BPA and phthalate levels did not differ significantly between groups, LH correlated positively with several DEHP metabolites among CPP cases (rs = 0.34–0.45, p < 0.05). Specifically, di(2-ethylhexyl) phthalate (DEHP)-related metabolites—mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)—were most consistently associated. Logistic regression suggested an increased risk trend for the molar sum of three DEHP metabolites (∑₃DEHP; OR = 2.18; 95 % CI: 0.86–5.52) and the sum of high-molecular-weight (HMW) phthalates (∑HMW; OR = 1.91; 95 % CI: 0.77–4.78), though not statistically significant. Cortisol levels did not differ between groups, but in CPP cases, moderate positive correlations were observed with MECPP and monobenzyl phthalate. BPA showed no significant associations with reproductive hormones or cortisol. Mediation analysis indicated borderline indirect effects via LH for several DEHP metabolites (MEOHP, MEHHP) and monobutyl phthalate (MnBP). Although MnBP showed the largest effect estimate, MEOHP was the most statistically suggestive (indirect effect = 0.79, p = 0.077). In conclusion, DEHP-related phthalates may influence early pubertal development through LH-mediated pathways. This study is novel in identifying LH as a potential mediator and detecting cortisol–phthalate correlations in CPP cases, underscoring the need for larger longitudinal cohorts with repeated biomonitoring to validate these findings.

越来越多的人担心，内分泌干扰化学物质（EDCs）可能会导致中枢性性早熟（CPP）的发病率上升。本病例对照研究考察了尿中邻苯二甲酸代谢物和双酚A （BPA）浓度是否与CPP风险相关。我们在2021年至2025年间从沙特阿拉伯的一家三级医院招募了77名女孩（20名特发性CPP患者和57名年龄匹配的对照组）。采用超高效液相色谱-串联质谱法定量尿液EDCs，并评估血清生殖激素，包括黄体生成素（LH）、促卵泡激素、雌二醇和皮质醇。虽然尿中BPA和邻苯二甲酸盐水平在两组之间没有显著差异，但在CPP病例中，LH与几种DEHP代谢物呈正相关（rs = 0.34-0.45, p < 0.05）。具体来说，邻苯二甲酸二（2-乙基己基）酯（DEHP）相关代谢物-邻苯二甲酸单（2-乙基-5-羧基戊基）酯（MECPP）、邻苯二甲酸单（2-乙基-5-氧己基）酯（MEOHP）和邻苯二甲酸单（2-乙基-5-羟基己基）酯(MEHHP) -最一致地相关。Logistic回归结果显示，三种DEHP代谢物的摩尔和（∑3DEHP; OR = 2.18; 95% CI: 0.86 ~ 5.52）和高分子量邻苯二甲酸酯（∑HMW; OR = 1.91; 95% CI: 0.77 ~ 4.78）的风险增加趋势，但无统计学意义。皮质醇水平在两组之间没有差异，但在CPP病例中，MECPP和邻苯二甲酸一苯酯观察到中度正相关。BPA与生殖激素或皮质醇没有明显的联系。中介分析表明，LH对几种DEHP代谢物（MEOHP， MEHHP）和邻苯二甲酸一丁酯（MnBP）有边缘性间接影响。虽然MnBP显示了最大的效应估计，但MEOHP最具统计学暗示（间接效应= 0.79,p = 0.077）。总之，dehp相关的邻苯二甲酸盐可能通过lh介导的途径影响青春期早期发育。这项研究在确定黄体生成素作为潜在介质和检测CPP病例中皮质醇-邻苯二甲酸盐相关性方面是新颖的，强调需要更大的纵向队列和重复的生物监测来验证这些发现。

{"title":"Urinary phthalate metabolites and central precocious puberty in girls: Evidence for luteinizing hormone mediation","authors":"Iman Al-Saleh , Rola Elkhatib , Afaf Alsagheir , Habiba Sultana , Khalid Alhusayn , Saleh Aldgither , Syed N Alvi , Yara Aljerayed , Mawadah Baali , Edward Devol","doi":"10.1016/j.hazadv.2025.100955","DOIUrl":"10.1016/j.hazadv.2025.100955","url":null,"abstract":"<div><div>There is growing concern that endocrine-disrupting chemicals (EDCs) may contribute to the rising incidence of central precocious puberty (CPP). This case-control study examined whether urinary concentrations of phthalate metabolites and bisphenol A (BPA) are associated with CPP risk. We recruited 77 girls (20 with idiopathic CPP and 57 age-matched controls) between 2021 and 2025 from a tertiary hospital in Saudi Arabia. Urinary EDCs were quantified using ultra-performance liquid chromatography–tandem mass spectrometry, and serum reproductive hormones, including luteinizing hormone (LH), follicle-stimulating hormone, estradiol, and cortisol, were assessed. Although urinary BPA and phthalate levels did not differ significantly between groups, LH correlated positively with several DEHP metabolites among CPP cases (rs = 0.34–0.45, <em>p</em> < 0.05). Specifically, di(2-ethylhexyl) phthalate (DEHP)-related metabolites—mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)—were most consistently associated. Logistic regression suggested an increased risk trend for the molar sum of three DEHP metabolites (∑<sub>3</sub>DEHP; OR = 2.18; 95 % CI: 0.86–5.52) and the sum of high-molecular-weight (HMW) phthalates (∑HMW; OR = 1.91; 95 % CI: 0.77–4.78), though not statistically significant. Cortisol levels did not differ between groups, but in CPP cases, moderate positive correlations were observed with MECPP and monobenzyl phthalate. BPA showed no significant associations with reproductive hormones or cortisol. Mediation analysis indicated borderline indirect effects via LH for several DEHP metabolites (MEOHP, MEHHP) and monobutyl phthalate (M<em>n</em>BP). Although M<em>n</em>BP showed the largest effect estimate, MEOHP was the most statistically suggestive (indirect effect = 0.79, <em>p</em> = 0.077). In conclusion, DEHP-related phthalates may influence early pubertal development through LH-mediated pathways. This study is novel in identifying LH as a potential mediator and detecting cortisol–phthalate correlations in CPP cases, underscoring the need for larger longitudinal cohorts with repeated biomonitoring to validate these findings.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100955"},"PeriodicalIF":7.7,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Removal of tetracycline from water using immobilized laccase on polyvinyl alcohol-gum Arabic hydrogel nanocomposites 聚乙烯醇-阿拉伯胶水凝胶纳米复合材料固定化漆酶去除水中四环素的研究

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-28 DOI: 10.1016/j.hazadv.2025.100954

Naghmeh Taghizadeh , Shohreh Ariaeenejad , Elaheh Motamedi

This study explored the synthesis of the hydrogel nanocomposite based on gum Arabic (GA) and polyvinyl alcohol (PVA) reinforced with Fe₂O₃ nanoparticles incorporated onto nanocellulose (NC-Fe). The water absorbencies of the hydrogels varied from 33.1 to 217.1 g/g, depending on Fe/NC and cross-linker content, as well as PVA molecular weight. The SEM images of the hydrogels revealed that the presence of Fe/NC led to smaller pores in the hydrogel matrix (i.e., pore size range of 6.9–50 µm in hydrogel nanocomposite vs. 8.3–63.3 μm in the pristine hydrogel). The immobilization of a metagenomic laccase (PersiLac3) onto the hydrogels provided an efficient, innovative, and multi-functional system for the removal of the antibiotic tetracycline (TC) from water. Immobilizing PersiLac3 on both the pristine hydrogel (PVA-GA-hydrogel) and the hydrogel nanocomposite (PVA-GA-hydrogel/NC-Fe) remarkably boosted its performance in TC removal compared to the free enzyme. At an initial TC concentration of 500 mg/L, the maximum removal reached 83 %, 67 %, and 38 % for PersiLac3@PVA-GA-hydrogel/NC-Fe, PersiLac3@PVA-GA-hydrogel, and the free PersiLac3, respectively, within 60 min. Moreover, the TC removal performance of the neat hydrogels (48 % for PVA-GA-hydrogel/NC-Fe and 17 % for PVA-GA-hydrogel) suggested that the antibiotic was eliminated through the combined processes of adsorption by the hydrogels and enzymatic degradation by PersiLac3. Addition of NC-Fe in the hydrogel played a bi-functional role in TC removal: it reduced the pore size, thereby increasing TC sorption by the hydrogel, and it acted as a Fenton-like catalyst in TC degradation. Finally, the immobilized enzyme demonstrated superior stability in harsh environments compared to the free enzyme, removing 70 % of TC after six consecutive runs. This is the first report on the potential application of the bio-based PVA–GA/Fe–NC hydrogel as a robust, reusable, and eco-friendly carrier for metagenomic laccase in antibiotic degradation, offering a novel strategy for sustainable water treatment.

本研究探索了以阿拉伯胶（GA）和聚乙烯醇（PVA）为基础的水凝胶纳米复合材料的合成，并将Fe2O3纳米颗粒掺入纳米纤维素（NC-Fe）中。水凝胶的吸水率在33.1 ~ 217.1 g/g之间变化，取决于Fe/NC和交联剂的含量，以及PVA的分子量。水凝胶的SEM图像显示，Fe/NC的存在导致水凝胶基质中的孔隙变小（即水凝胶纳米复合材料的孔径范围为6.9-50 μm，而原始水凝胶的孔径范围为8.3-63.3 μm）。将宏基因组漆酶（PersiLac3）固定在水凝胶上，为从水中去除抗生素四环素（TC）提供了一种高效、创新和多功能的系统。与游离酶相比，将PersiLac3固定在原始水凝胶（pva - ga -水凝胶）和纳米复合水凝胶（pva - ga -水凝胶/NC-Fe）上显著提高了其去除TC的性能。初始TC浓度为500 mg/L时，对PersiLac3@PVA-GA-hydrogel/NC-Fe、PersiLac3@PVA-GA-hydrogel和游离PersiLac3的去除率分别在60 min内达到83%、67%和38%。此外，纯水凝胶的TC去除性能（pva - ga -水凝胶/NC-Fe为48%，pva - ga -水凝胶为17%）表明，通过水凝胶吸附和PersiLac3酶降解的联合过程，抗生素被消除了。在水凝胶中加入NC-Fe对TC的去除具有双重功能：减小了孔隙大小，从而增加了水凝胶对TC的吸附；同时在TC的降解中起到了类芬顿催化剂的作用。最后，与游离酶相比，固定化酶在恶劣环境中表现出更好的稳定性，在连续六次运行后去除70%的TC。本文首次报道了生物基PVA-GA / Fe-NC水凝胶作为宏基因组漆酶在抗生素降解中的强大、可重复使用和环保载体的潜在应用，为可持续水处理提供了一种新的策略。

{"title":"Removal of tetracycline from water using immobilized laccase on polyvinyl alcohol-gum Arabic hydrogel nanocomposites","authors":"Naghmeh Taghizadeh , Shohreh Ariaeenejad , Elaheh Motamedi","doi":"10.1016/j.hazadv.2025.100954","DOIUrl":"10.1016/j.hazadv.2025.100954","url":null,"abstract":"<div><div>This study explored the synthesis of the hydrogel nanocomposite based on gum Arabic (GA) and polyvinyl alcohol (PVA) reinforced with Fe<sub>2</sub>O<sub>3</sub> nanoparticles incorporated onto nanocellulose (NC-Fe). The water absorbencies of the hydrogels varied from 33.1 to 217.1 g/g, depending on Fe/NC and cross-linker content, as well as PVA molecular weight. The SEM images of the hydrogels revealed that the presence of Fe/NC led to smaller pores in the hydrogel matrix (i.e., pore size range of 6.9–50 µm in hydrogel nanocomposite vs. 8.3–63.3 μm in the pristine hydrogel). The immobilization of a metagenomic laccase (PersiLac3) onto the hydrogels provided an efficient, innovative, and multi-functional system for the removal of the antibiotic tetracycline (TC) from water. Immobilizing PersiLac3 on both the pristine hydrogel (PVA-GA-hydrogel) and the hydrogel nanocomposite (PVA-GA-hydrogel/NC-Fe) remarkably boosted its performance in TC removal compared to the free enzyme. At an initial TC concentration of 500 mg/L, the maximum removal reached 83 %, 67 %, and 38 % for PersiLac3@PVA-GA-hydrogel/NC-Fe, PersiLac3@PVA-GA-hydrogel, and the free PersiLac3, respectively, within 60 min. Moreover, the TC removal performance of the neat hydrogels (48 % for PVA-GA-hydrogel/NC-Fe and 17 % for PVA-GA-hydrogel) suggested that the antibiotic was eliminated through the combined processes of adsorption by the hydrogels and enzymatic degradation by PersiLac3. Addition of NC-Fe in the hydrogel played a bi-functional role in TC removal: it reduced the pore size, thereby increasing TC sorption by the hydrogel, and it acted as a Fenton-like catalyst in TC degradation. Finally, the immobilized enzyme demonstrated superior stability in harsh environments compared to the free enzyme, removing 70 % of TC after six consecutive runs. This is the first report on the potential application of the bio-based PVA–GA/Fe–NC hydrogel as a robust, reusable, and eco-friendly carrier for metagenomic laccase in antibiotic degradation, offering a novel strategy for sustainable water treatment.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100954"},"PeriodicalIF":7.7,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145685541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative tomography of contaminant phytomobilization: β+ emitters 83Sr and 86Y as tracers of fission-product analog mobility 污染物植物迁移的定量断层扫描：β+发射体83Sr和86Y作为裂变产物类似物迁移率的示踪剂

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-22 DOI: 10.1016/j.hazadv.2025.100952

Jann Schöngart , Marcel Lindemann , Max Klotzsche , Karsten Franke , Cornelius Fischer

The mobility of fission-product analogs in sandy soil and phytoremediation contexts was investigated using positron emission tomography (PET) ⁸³Sr²⁺ and ⁸⁶Y³⁺ β⁺ tracers. Flow experiments in quartz and FeOOH-coated sands revealed limited baseline mobility of ⁸⁶Y³⁺. Chelating agents enhanced transport: citrate mobilized ⁸⁶Y³⁺ in quartz sand, while NTA was required for FeOOH-coated sand. Phosphate reduced citrate-driven mobilization, highlighting chemical controls on rare earth element transport relevant in the phytoremediation context. High-resolution ⁸³Sr²⁺ PET captured millimeter-scale heterogeneities in hydrodynamics, with ammonium nitrate mobilization producing mean velocities of 55.8 mm·h⁻¹.

Phytomobilization experiments with Avena strigosa demonstrated plant-mediated contaminant movement. Localized radiotracer injections remained confined due to strong adsorption, with ⁸³Sr²⁺ showing tracer cloud velocities of 33–360 μm·h⁻¹ and ⁸⁶Y exhibiting minimal mobilization. Detection of radiotracer concentrations down to 0.1 fmol·mm⁻³ provides quantitative insight into substrate-dependent transport processes.

The results validate the capabilities of PET for high-resolution quantification of radiometal mobility in both abiotic and plant-mediated remediation scenarios. The datasets provide an estimate for assessing the time-scales on which remediation efforts should be planned. In addition, the introduction of novel radiotracers, experimental designs and methods for data validation lay the groundwork for ex-situ research concerning remediation and environmental safety.

利用正电子发射断层扫描（PET） 83Sr2+和86Y3+ β +示踪剂研究了裂变产物类似物在沙质土壤和植物修复环境中的迁移率。石英和feooh包覆砂的流动实验表明，86Y3+的基线迁移率有限。螯合剂增强了运输：柠檬酸盐在石英砂中调动了86Y3+，而在feoh包覆砂中则需要NTA。磷酸盐减少了柠檬酸盐驱动的动员，突出了与植物修复相关的稀土元素运输的化学控制。高分辨率的83Sr2+ PET捕捉到了流体力学中毫米尺度的非均质性，硝酸铵的动员产生了55.8 mm·h⁻¹的平均速度。藻化实验证明了植物介导的污染物运动。由于强吸附，局部放射性示踪剂注射仍然受到限制，83Sr2+的示踪剂云速度为33-360 μm·h⁻¹，86Y的示踪剂云速度最小。对低至0.1 fmol·mm的放射性示踪剂浓度的检测提供了对底物依赖性运输过程的定量洞察。结果验证了PET在非生物和植物介导的修复方案中高分辨率量化放射性金属迁移的能力。这些数据集为评估应在何种时间尺度上规划补救工作提供了估计。此外，新的放射性示踪剂、实验设计和数据验证方法的引入为有关修复和环境安全的非原位研究奠定了基础。

{"title":"Quantitative tomography of contaminant phytomobilization: β+ emitters 83Sr and 86Y as tracers of fission-product analog mobility","authors":"Jann Schöngart , Marcel Lindemann , Max Klotzsche , Karsten Franke , Cornelius Fischer","doi":"10.1016/j.hazadv.2025.100952","DOIUrl":"10.1016/j.hazadv.2025.100952","url":null,"abstract":"<div><div>The mobility of fission-product analogs in sandy soil and phytoremediation contexts was investigated using positron emission tomography (PET) <sup>83</sup>Sr<sup>2+</sup> and <sup>86</sup>Y<sup>3+</sup> β⁺ tracers. Flow experiments in quartz and FeOOH-coated sands revealed limited baseline mobility of <sup>86</sup>Y<sup>3+</sup>. Chelating agents enhanced transport: citrate mobilized <sup>86</sup>Y<sup>3+</sup> in quartz sand, while NTA was required for FeOOH-coated sand. Phosphate reduced citrate-driven mobilization, highlighting chemical controls on rare earth element transport relevant in the phytoremediation context. High-resolution <sup>83</sup>Sr<sup>2+</sup> PET captured millimeter-scale heterogeneities in hydrodynamics, with ammonium nitrate mobilization producing mean velocities of 55.8 mm·h⁻¹.</div><div>Phytomobilization experiments with <em>Avena strigosa</em> demonstrated plant-mediated contaminant movement. Localized radiotracer injections remained confined due to strong adsorption, with <sup>83</sup>Sr<sup>2+</sup> showing tracer cloud velocities of 33–360 μm·h⁻¹ and <sup>86</sup>Y exhibiting minimal mobilization. Detection of radiotracer concentrations down to 0.1 fmol·mm⁻³ provides quantitative insight into substrate-dependent transport processes.</div><div>The results validate the capabilities of PET for high-resolution quantification of radiometal mobility in both abiotic and plant-mediated remediation scenarios. The datasets provide an estimate for assessing the time-scales on which remediation efforts should be planned. In addition, the introduction of novel radiotracers, experimental designs and methods for data validation lay the groundwork for <em>ex-situ</em> research concerning remediation and environmental safety.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100952"},"PeriodicalIF":7.7,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0