Journal of hazardous materials advances最新文献_第9页

Simultaneous determination of eight tetracyclines in cattle hair using UPLC-QTRAP/MS: A novel non-invasive strategy for veterinary drug residue UPLC-QTRAP/MS同时测定牛毛中8种四环素类药物：一种新的兽药残留无创检测策略

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-01 DOI: 10.1016/j.hazadv.2025.100939

Zhanteng Song , Zhixin An , Maerhaba Paerhati , Adilitai Tielik , Jinrong Zhu , Gayna Serhali , Decheng Suo

The environmental residues caused by the abuse of tetracycline antibiotics (TCS) in animal husbandry threaten ecology and human health through the food chain, but the traditional biological matrix (such as blood and urine) is difficult to achieve long-term drug monitoring due to its strong invasiveness and short metabolic cycle. In this study, a high sensitivity method based on UPLC-Qtrap/MS was established, using bovine hair as a non-invasive detection matrix, which can simultaneously detect eight tetracycline antibiotics. The method validation showed that the linear correlation coefficient was>0.999, the recovery was 82.79 – 98.55 %, the coefficient of variation was<15 %, the limit of detection (LOD) and limit of quantification (LOQ) were 0.3 ng/kg and 1.0 ng/kg, respectively, which was significantly better than the existing methods. The method was successfully applied to a pilot study of 50 cattle hair samples from the northern region of Xinjiang, China, demonstrating its practical applicability. The microstructure, chemical composition and possible metabolic pathways into the hair after treatment with tetracycline were briefly investigated.The result and research shows that cattle hair can stably enrich drug residues for a long time, which provides an innovative solution for tracing illegal drug use in animal husbandry, and provides technical support for the formulation of new drug regulatory standards and environmental health risk assessment.

畜牧业滥用四环素类抗生素（TCS）造成的环境残留物通过食物链威胁生态和人类健康，但传统的生物基质（如血液和尿液）因其侵入性强、代谢周期短，难以实现长期的药物监测。本研究以牛毛为无创检测基质，建立了一种基于UPLC-Qtrap/MS的高灵敏度检测方法，可同时检测8种四环素类抗生素。方法验证表明，线性相关系数为0.999，回收率为82.79 ~ 98.55%，变异系数为15%，检出限（LOD）和定量限（LOQ）分别为0.3 ng/kg和1.0 ng/kg，显著优于现有方法。该方法已成功应用于中国新疆北部地区50份牛毛样品的中试研究，证明了该方法的实用性。简要研究了四环素处理后毛发的微观结构、化学成分和可能的代谢途径。结果与研究表明，牛毛可长期稳定富集药物残留，为畜牧业非法用药溯源提供创新解决方案，为新药监管标准制定和环境健康风险评估提供技术支撑。

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引用次数: 0

Physicochemical and mineralogical characterization of spent and unspent cupels in Ghana; implication for recycling 加纳废石和未废石的物化学和矿物学特征；对回收的影响

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-01 DOI: 10.1016/j.hazadv.2025.100925

Eliot Pappoe , Bennetta Koomson , Patrick Boakye

Ghana’s gold mining sector plays a crucial role in national economic development with fire assay method serving as a technique for accurate determination of precious metal content. One key component of this process is the use of cupels, a small porous ceramic material used in cupellation process to quantify the amount of Gold present in ore. As part of the process, lead metal is absorbed into the cupel in a form of lead oxide leaving gold and silver prill as a solid. This paper aims to analyse the physical, chemical and mineralogical features of both unspent and spent cupels from three mine assay laboratories in Ghana. Mass fraction showed significant negative correlation with unspent cupel weight (p=0.012) and positive correlation with weight difference. Lead was found to be averagely 28 wt% in spent cupels. Analytical techniques were used and the results revealed variations in mineral and elemental phase in unspent and spent cupel from the selected mine assay laboratories which influences the performance and also its environmental impact. Appreciable amount of lead was found to be contained in the spent cupels. Future studies are needed to control lead mobility in the soil and possible regeneration of cupels using green methods.

加纳的黄金开采部门在国家经济发展中发挥着至关重要的作用，火测定法是一种准确测定贵金属含量的技术。该工艺的一个关键组成部分是铜杯的使用，铜杯是一种小型多孔陶瓷材料，用于制杯过程中量化矿石中金的含量。作为该工艺的一部分，铅金属以氧化铅的形式被吸收到铜杯中，留下金和银颗粒作为固体。本文的目的是分析物理，化学和矿物学特征，从三个矿山实验室在加纳的未使用和使用的杯子。质量分数与未废毛坯质量呈显著负相关（p=0.012），与毛坯质量差呈正相关。在用过的杯子中，铅的平均含量为28%。分析技术的使用和结果揭示了矿物和元素相的变化，从选定的矿山化验实验室的未使用和使用过的cupel影响性能和它的环境影响。在用过的杯子中发现了相当数量的铅。未来的研究需要控制铅在土壤中的流动性和可能的绿色再生方法。

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引用次数: 0

Urban wetlands as buffers against airborne microplastics and associated pollutants: Implications for public health and sustainable urban management 城市湿地对空气中微塑料和相关污染物的缓冲作用：对公共健康和可持续城市管理的影响

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-01 DOI: 10.1016/j.hazadv.2025.100940

Sneha Gautam , S Rathikannu , Gareth Cooper Marbaniang , Pawan Gupta , Deborah Grace Varghese , Chang-Hoi Ho

This study investigated the role of Ukkadam Lake, an urban wetland in Coimbatore, India, as both a sink and secondary source of airborne microplastics, and explored their implications for respiratory health. The selection of this urban wetland was motivated by its ecological significance and increasing vulnerability to anthropogenic pollution, particularly from urban runoff. The deterioration of the site has been progressive in recent years, owing to the discharge of untreated effluents and sewage, as well as the invasive proliferation of water hyacinth. Special emphasis was placed on the combined impacts of microplastic pollution and fine particulate matter on respiratory health issues. The FTIR analysis detected five main types of polymers in the samples: polyethylene (38.5%), polypropylene (27.3%), PET (19.6%), polystyrene (9.4%), and PVC (5.2%). Among these, PET was the most common in aquatic plants, revealing the bioaccumulation of microplastics in the vegetation. GIS mapping showed that pollution hotspots were mainly found near urban–wetland boundaries. Dispersion modeling (HYSPLIT) indicated that airborne microplastics can rise up to 1500 m and travel more than 350 km. Seasonal weather patterns and prevailing winds strongly influence their movement. In summary, the results revealed a significant association between airborne microplastic exposure and respiratory health risks in the local population. These suggested the urgent need for targeted mitigation strategies, including the restoration and active management of urban wetlands, enhanced regulation of point and non-point pollution sources, and the development of integrated monitoring frameworks to support sustainable urban ecological management and public health protection.

本研究调查了印度哥印拜陀的城市湿地Ukkadam湖作为空气中微塑料的汇和二次来源的作用，并探讨了它们对呼吸健康的影响。选择这片城市湿地的动机是其生态意义和日益增加的对人为污染的脆弱性，特别是来自城市径流的污染。近年来，由于排放未经处理的废水和污水，以及水葫芦的侵入性繁殖，该地点的情况日益恶化。特别强调了微塑料污染和细颗粒物对呼吸健康问题的综合影响。FTIR分析检测到样品中的五种主要聚合物：聚乙烯（38.5%）、聚丙烯（27.3%）、PET（19.6%）、聚苯乙烯（9.4%）和PVC（5.2%）。其中，PET在水生植物中最常见，揭示了微塑料在植被中的生物积累。GIS制图显示，污染热点主要集中在城市-湿地边界附近。分散模型（HYSPLIT）表明，空气中的微塑料可以上升到1500米，传播超过350公里。季节性天气模式和盛行风强烈影响它们的移动。总之，研究结果揭示了空气中微塑料暴露与当地人口呼吸健康风险之间的显著关联。这表明迫切需要制定有针对性的缓解战略，包括恢复和积极管理城市湿地，加强对点和非点污染源的监管，以及制定综合监测框架，以支持可持续的城市生态管理和公共健康保护。

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引用次数: 0

Heavy metal mixture exposure and diabetes-related multiple long-term conditions (MLTC): Intermetallic interactions and the mediating role of biological age 重金属混合物暴露与糖尿病相关多重长期疾病（MLTC）：金属间相互作用和生物年龄的中介作用

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-01 DOI: 10.1016/j.hazadv.2025.100933

Ziyu Dong , Guohuan Yin , Jingtao Wu , Amujilite , Qun Xu

Long-term exposure to heavy metals is an emerging environmental risk factor for diabetes-related multiple long-term conditions (MLTC). Epidemiological evidence on combined exposures and intermetallic interactions is limited, and the mediating role of biological aging remains understudied. We conducted a longitudinal study from 2016 to 2021, including 473 elderly residents (1892 person-visits) chronically exposed to chromium (Cr), cadmium (Cd), manganese (Mn), and lead (Pb) in a heavily industrialized area of Liaoning Province, China. Linear mixed effects (LME) models examined single-metal associations with MLTC, and Bayesian Kernel Machine Regression (BKMR) was utilized to assess overall mixture exposure effects. Metal interactions were evaluated through Marginal effects models. Additionally, biological aging acceleration (KDM.Accel) was analyzed as a mediator using cross-lagged panel modeling (CLPM). Single-metal analysis indicated significant positive associations of urinary Cr, Cd, and Pb with diabetes-related MLTC, whereas Mn was inversely associated. Notably, BKMR analysis demonstrated a significant positive relationship between heavy metal mixture exposure and increased MLTC risk, particularly at higher combined concentrations. Interaction analyses revealed complex antagonistic interactions between Mn*Cr and Mn*Cd, synergistic interactions between Cr*Pb, and a three-way synergistic interaction involving Cr*Cd*Mn. Mediation analyses further indicated biological aging significantly mediated associations of Cd and Pb exposure with MLTC risk. This study provides supportive epidemiological evidence that exposure to heavy metal mixtures significantly elevates diabetes-related MLTC risk through complex intermetallic interactions. Furthermore, biological aging emerges as an important mediator, highlighting the potential for targeting aging processes in environmental health interventions.

长期接触重金属是糖尿病相关多重长期疾病（MLTC）的一个新兴环境风险因素。关于联合暴露和金属间相互作用的流行病学证据有限，生物老化的中介作用仍未得到充分研究。2016年至2021年，我们对中国辽宁省重度工业化地区的473名长期暴露于铬（Cr）、镉（Cd）、锰（Mn）和铅（Pb）的老年居民（1892人次）进行了纵向研究。线性混合效应（LME）模型检验了单一金属与MLTC的关联，贝叶斯核机回归（BKMR）用于评估总体混合暴露效应。通过边际效应模型评估金属相互作用。此外，使用交叉滞后面板模型（CLPM）分析生物老化加速（KDM.Accel）作为中介。单金属分析表明尿Cr、Cd和Pb与糖尿病相关的MLTC呈显著正相关，而Mn呈负相关。值得注意的是，BKMR分析表明，重金属混合物暴露与MLTC风险增加之间存在显著的正相关关系，特别是在较高的综合浓度下。相互作用分析显示Mn*Cr和Mn*Cd之间存在复杂的拮抗相互作用，Cr*Pb之间存在协同相互作用，Cr*Cd*Mn之间存在三方协同相互作用。中介分析进一步表明，生物老化显著介导了Cd和Pb暴露与MLTC风险的关联。本研究提供了支持性的流行病学证据，表明重金属混合物暴露通过复杂的金属间相互作用显著提高糖尿病相关的MLTC风险。此外，生物衰老作为一个重要的中介，突出了在环境健康干预中针对衰老过程的潜力。

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引用次数: 0

Changes in microbial community structure and responses to environmental factors in heavily polluted rivers remediated by bio-wax 生物蜡修复重污染河流微生物群落结构变化及其对环境因子的响应

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-01 DOI: 10.1016/j.hazadv.2025.100930

Lei Dong , Li Lin , Quanxi Xu , Liangyuan Zhao , Xingrui Qi , Guochuan Yin , Xiong Pan , Aihua Xu , Yujie Liu

Bio-wax is a biocomposite carrier that slowly releases bio-promoting factors for remediation by enriching and activating microbes to restore water quality. This study examined microbial community changes in the Xun Si River in Wuhan, China, to evaluate the efficacy of bio-wax application in environmental restoration. Water samples were monitored over a 7-month treatment period for changes in chemical oxygen demand (COD), ammonia nitrogen (NH₃-N), total phosphorus (TP), and total nitrogen (TN). Microbial communities were characterized using 16S rRNA high-throughput sequencing. Results showed that, based on the Surface Water Environment Quality Standards (GB3838–2002), COD, NH₃-N, and TP decreased from Class IV to predominantly Class I–II, demonstrating a substantial reduction in eutrophication. Although α-diversity indices remained similar between treatment and control groups, bio-wax significantly altered microbial community composition at the genus level, in which Nitrospira with an average relative abundance of 4.8 % dominated treatment groups; Cloacibacterium, Dechloromonas with an average relative abundance of 6.9 % each co-dominated control groups. Notably, the relative abundance of Acinetobacter and Limnohabitans decreased, whereas Sphingomonas and Dechloromonas increased, reflecting enhanced ecological resilience. Correlation analysis identified COD and TN as the main environmental drivers of community shifts. Acinetobacter, Limnohabitans, Dechloromonas, and Sphingomonas emerged as indicator microorganisms for ecological assessment. These findings highlight the dual function of bio-wax in improving water quality and modulating microbial assemblages. Therefore, bio-wax is a sustainable and scalable strategy for river restoration that offers a framework for microbial-based water quality monitoring.

生物蜡是一种生物复合载体，通过富集和激活微生物，缓慢释放生物促进因子进行修复，从而恢复水质。通过对武汉逊斯河微生物群落变化的研究，评价生物蜡在环境修复中的应用效果。在7个月的处理期间监测水样的化学需氧量（COD）、氨氮（NH₃-N）、总磷（TP）和总氮（TN）的变化。采用16S rRNA高通量测序对微生物群落进行了表征。结果表明，根据地表水环境质量标准（GB3838-2002）， COD、NH₃-N和TP从IV类下降到主要是I-II类，表明富营养化明显减少。虽然处理组α-多样性指数与对照组相似，但生物蜡在属水平上显著改变了微生物群落组成，其中硝化螺旋菌的平均相对丰度为4.8%；阴沟杆菌和脱氯单胞菌的平均相对丰度均为6.9%。值得注意的是，不动杆菌和Limnohabitans的相对丰度下降，而鞘脂单胞菌和脱氯单胞菌的相对丰度增加，反映了生态恢复能力的增强。相关性分析表明，COD和TN是群落迁移的主要环境驱动因素。不动杆菌、Limnohabitans、脱氯单胞菌和鞘氨单胞菌成为生态评价的指示微生物。这些发现强调了生物蜡在改善水质和调节微生物组合方面的双重功能。因此，生物蜡是一种可持续和可扩展的河流恢复策略，为基于微生物的水质监测提供了框架。

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引用次数: 0

Identification of by-products in the degradation process of diclofenac in water using solar photo-Fenton process 双氯芬酸在水中降解副产物的太阳光fenton法鉴定

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-01 DOI: 10.1016/j.hazadv.2025.100924

Leydi C. Parra-Enciso , Ainhoa Rubio-Clemente , Boris Santiago Avila Taborda , Gustavo A. Peñuela

In the last two decades, pharmaceuticals have become an environmental problem due to their presence in wastewater, surface water and even drinking water sources. Many medications are used daily, leaving residual waste in wastewater since the elimination processes by water treatment plants are not efficient in removing these compounds. A drug that is more commonly detected in the aquatic environment is the analgesic diclofenac (DCF). In the present work, several degradation by-products of 1 mg l^-1 of DCF under optimal operating conditions previously optimized (0.20 mg l^-1 of Fe²⁺ and 1 mg l^-1 of H₂O₂) at a simulated solar irradiance of 425 W m^-2 were identified. Due to its complex structure and the non-selective nature of the hydroxyl radical (OH•), several degradation routes were proposed for DCF. It can be observed that hydroxylated diclofenac has been identified through the degradation of DCF by the photo-Fenton process under the experimental domain tested. This structure undergoes additional hydroxylation in the benzene ring containing the chlorine atoms, causing their loss and subsequent hydroxylation and, finally, resulting in the cleavage of the CN bond. The dechlorination, hydroxylation and decarboxylation processes of the DCF emerging compound allow the formation of degradation by-products that are less toxic than the parent compound to be elucidated. In this regard, the possible application of the solar photo-Fenton process under the operating conditions tested here at a larger scale could be inferred.

在过去的二十年里，药物已经成为一个环境问题，因为它们存在于废水、地表水甚至饮用水源中。许多药物每天都在使用，在废水中留下残留的废物，因为水处理厂的消除过程不能有效地去除这些化合物。在水生环境中更常见的一种药物是镇痛药双氯芬酸（DCF）。在模拟太阳辐照度为425 W m-2的条件下，在先前优化的最佳操作条件（0.20 mg l-1 Fe2+和1 mg l-1 H2O2）下，鉴定了几种1 mg l-1 DCF降解副产物。由于其复杂的结构和羟基自由基（OH•）的非选择性，人们提出了几种降解DCF的途径。可以观察到，在实验测试域下，通过光- fenton法降解DCF，已鉴定出羟基化双氯芬酸。这种结构在含有氯原子的苯环上发生额外的羟基化，导致氯原子的丢失和随后的羟基化，最后导致CN键的断裂。DCF新兴化合物的脱氯、羟基化和脱羧过程允许形成比母体化合物毒性更小的降解副产物。在这方面，可以推断在这里测试的操作条件下太阳能光芬顿工艺在更大规模上的可能应用。

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引用次数: 0

Complementary roles of drinking water and rice in mineral intake and metal exposure: Insights from a longevity region in Southern Hainan, China 饮用水和大米在矿物质摄入和金属暴露中的互补作用：来自中国海南南部长寿地区的见解

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-01 DOI: 10.1016/j.hazadv.2025.100950

Yangchun Han , Shixi Zhang , Xiaoyun Yan , Kun Zheng , Yifan He , Kunli Luo

Growing concerns over aging and food safety highlight the need to evaluate both nutritional benefits and toxic risks in daily diets. This study assessed exposure to 27 elements in drinking water and rice from southern Hainan, China—a recognized longevity region. Of the samples analyzed, 10.4% of water and 18.8% of rice were non-compliant with national safety standards. Using Monte Carlo simulation, we estimated the probabilistic intake of essential minerals and assessed non-carcinogenic risks from heavy meta(loid)s. Drinking water contributed little to mineral intake, covering at most 10.9% of Mn needs for children and 21.6% for adults. In contrast, rice was identified as a major dietary source of Fe, Zn, Mg, Cu, and P, with Cr intake reaching 639.8% and 853.1% of the recommended daily levels for children and adults, respectively. Health risk assessments showed negligible risks from water but higher risks from rice, especially for children. Arsenic in rice was the dominant risk driver, followed by Cr. Multivariate statistics confirmed these elements are co-transported with essential nutrients during plant uptake, suggesting that simply cleaning soils may be insufficient for reducing their presence in grains. This calls for an integrated approach that combines source control with targeted farming practices to reduce co-uptake of contaminants and nutrients. Cross-regional comparisons with 21 global regions revealed a complementary exposure profile in southern Hainan: while the drinking water is mineral-poor but safe, locally produced rice is nutrient-rich and poses manageable health risks.

对老龄化和食品安全日益增长的担忧凸显了评估日常饮食中的营养益处和有毒风险的必要性。这项研究评估了中国海南南部（公认的长寿地区）饮用水和大米中27种元素的暴露情况。在分析的样品中，10.4%的水和18.8%的大米不符合国家安全标准。使用蒙特卡罗模拟，我们估计了必需矿物质的概率摄入量，并评估了重金属（样物质）的非致癌风险。饮用水对矿物质摄入的贡献很小，最多只能满足儿童10.9%和成人21.6%的锰需求。相比之下，大米被确定为铁、锌、镁、铜和磷的主要膳食来源，铬的摄入量分别达到儿童和成人每日推荐摄入量的639.8%和853.1%。健康风险评估显示，来自水的风险可以忽略不计，但来自大米的风险更高，尤其是对儿童而言。水稻中的砷是主要的风险驱动因素，其次是铬。多元统计证实，这些元素在植物吸收过程中与必需营养素共同运输，这表明仅仅清洁土壤可能不足以减少它们在谷物中的存在。这需要一种综合方法，将源头控制与有针对性的耕作方法结合起来，以减少污染物和营养物质的共同吸收。与全球21个地区的跨区域比较揭示了海南南部的互补暴露概况：虽然饮用水缺乏矿物质但安全，但当地生产的大米营养丰富，构成可控的健康风险。

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引用次数: 0

Effects of vortex flow on the tiny particle transportation behavior in a swirling instrument 旋涡流动对旋流仪器中微小颗粒输运行为的影响

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-01 DOI: 10.1016/j.hazadv.2025.100943

Sina Gouran , Saad Alshahrani

This work examines the effect of the forced vortex phenomenon on particle transportation in a rotational flow field. The nonlinear governing equations of motion are solved analytically by a Collocation method. The results are in reasonable agreement with existing studies. Furthermore, changing the initial angular velocity of the fluid or the primary radius of the particle reveals a decreasing pattern in the particle location but an increasing pattern in the radial speed as the initial angular velocity increases. In addition, enlarging the primary particle sizes leads to particle location and tangential speed reduction.

本文研究了旋转流场中强迫涡现象对粒子输运的影响。用配点法解析求解了非线性运动控制方程。研究结果与已有的研究结果基本一致。此外，改变流体的初始角速度或颗粒的初始半径，颗粒的位置呈减小的趋势，而径向速度随初始角速度的增加而增加。此外，初始粒径的增大导致颗粒位置和切向速度的降低。

引用次数: 0

The radioactive waste management - State of the art and emerging technologies 放射性废物管理——最新技术和新兴技术

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-01 DOI: 10.1016/j.hazadv.2025.100932

Miguta Faustine Ngulimi , Kamal Asghar , Sion Kim , Bum Kyoung Seo , Changhyun Roh

The sustainable management of radioactive waste remains a critical challenge amid the global expansion of nuclear energy. Although nuclear power offers a reliable and low carbon energy source, its radioactive byproducts, if inadequately managed, pose significant environmental and public health risks. This review provides an integrated assessment of current and emerging strategies for radioactive waste management, encompassing waste minimization, treatment, immobilization, and characterization. Emphasis is placed on the hierarchical framework of waste management, which prioritizes reduction, recycling, and reuse over final disposal. The paper further examines recent advancements in waste characterization, including real-time monitoring, advanced imaging, and artificial intelligence, which together enhance spatial radionuclide mapping and predictive modeling of waste form behavior. Beyond technological innovation, the review underscores the importance of robust policy frameworks and active public engagement to ensure transparency, social acceptance, and regulatory coherence. By promoting adaptive, science based, and participatory approaches, the nuclear sector can advance safer and more sustainable pathways for radioactive waste management.

在全球核能扩张的背景下，放射性废物的可持续管理仍然是一项重大挑战。虽然核电提供了可靠的低碳能源，但其放射性副产品如果管理不当，会对环境和公众健康构成重大风险。这篇综述提供了对放射性废物管理的当前和新兴战略的综合评估，包括废物最小化，处理，固定化和表征。重点放在废物管理的层次框架上，优先考虑减少、回收和再利用，而不是最终处置。本文进一步探讨了废物表征方面的最新进展，包括实时监测、先进成像和人工智能，它们共同增强了空间放射性核素制图和废物形态行为的预测建模。除了技术创新，评估还强调了强有力的政策框架和积极的公众参与对确保透明度、社会接受度和监管一致性的重要性。通过促进适应性的、以科学为基础的和参与性的方法，核部门可以推进更安全、更可持续的放射性废物管理途径。

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引用次数: 0

Nanoplastics cause an increased risk of Parkinson’s disease compared to microplastics at environmental exposure levels 与环境暴露水平下的微塑料相比，纳米塑料导致帕金森病的风险增加

IF 7.7 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances

Pub Date : 2025-11-01 DOI: 10.1016/j.hazadv.2025.100941

Hyeju Jeong , Joycie Shanmugiah , Jaehee Jang , Do Hee Lee , Jonghoon Choi , Jin Su Kim

Recent evidence suggests a potential link between airborne microplastics (MP) and nanoplastics (NP) and neurodegenerative diseases, yet direct in vivo demonstration of their neurotoxicity remains limited. This study aimed to assess the potential risk of Parkinson’s disease (PD) associated with chronic inhalation exposure to polystyrene nanoplastics (PS-NP), by examining PD-relevant behavioral and neuropathological alterations compared to polystyrene microplastics (PS-MP). Adult mice were exposed daily to 100 ppm/200 µL of 20 nm PS-NP or 0.25 µm PS-MP via inhalation for 16 weeks. Brain uptake and exposed dose were quantified using ⁶⁴Cu-labeled PS and gamma counting. Behavioral assessments, histology, immunohistochemistry, western blotting, and RNA sequencing were performed to evaluate PD-relevant outcomes. Only 0.094 % of the estimated human-equivalent environmental dose was exposed to the substantia nigra and striatum. PS-NP exposure induced greater behavioral deficits compared to PS-MP. RNA-seq revealed dysregulation of PD-related genes, overlapping with those in MPTP-induced PD models. Western blot and immunohistochemistry confirmed reduced tyrosine hydroxylase, increased phospho-α-synuclein (Ser129) aggregation, and elevated markers of glial activation (GFAP, IBA1) and pro-inflammatory cytokines in the PS-NP group. Inhaled PS-NP induced PD-relevant neuropathological and behavioral changes, suggesting that chronic exposure may contribute to increased PD risk under environmentally realistic conditions. These findings emphasize the need to evaluate airborne NP exposure as a novel environmental risk factor for PD.

最近的证据表明，空气中的微塑料（MP）和纳米塑料（NP）与神经退行性疾病之间存在潜在联系，但其神经毒性的直接体内证明仍然有限。本研究旨在通过检测与聚苯乙烯微塑料（PS-MP）相比，与PD相关的行为和神经病理改变，评估慢性吸入暴露于聚苯乙烯纳米塑料（PS-NP）相关的帕金森病（PD）的潜在风险。成年小鼠每天吸入100 ppm/200µL的20 nm PS-NP或0.25µm PS-MP，持续16周。采用64cu标记的PS和伽马计数定量脑摄取和暴露剂量。通过行为评估、组织学、免疫组织化学、免疫印迹和RNA测序来评估pd相关结果。只有0.094%的估计人体等效环境剂量暴露于黑质和纹状体。与PS-MP相比，PS-NP暴露引起更大的行为缺陷。RNA-seq显示PD相关基因的失调，与mptp诱导的PD模型中的基因重叠。Western blot和免疫组化证实，PS-NP组酪氨酸羟化酶降低，磷酸-α-突触核蛋白（Ser129）聚集增加，胶质细胞活化标志物（GFAP, IBA1）和促炎细胞因子升高。吸入PS-NP诱导PD相关的神经病理和行为改变，提示在环境现实条件下，慢性暴露可能导致PD风险增加。这些发现强调有必要评估空气中NP暴露作为PD的一种新的环境风险因素。

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