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Exposure to Per- and Polyfluoroalkyl Substances and the Risk of Prostate and Ovarian Cancer: An Epidemiologic Meta-Analysis 暴露于全氟和多氟烷基物质与前列腺癌和卵巢癌的风险:一项流行病学荟萃分析。
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-05 DOI: 10.1002/ajim.23717
Shenglan Yang, Hui Dong, Xinyu Gou, Limei Chen, Ying Zhang, Jing Wu

Background

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants. Previous research has linked PFAS exposure to prostate and ovarian cancer risk, however, the conclusions have been inconsistent. This research purpose was to determine the relationship between PFAS exposure and prostate and ovarian cancer at the population level.

Methods

We systematically reviewed three databases—PubMed, Web of Science, and Embase—for research from when these databases were established to April 15, 2024. The quality of the retrieved research was evaluated using the Newcastle-Ottawa Scale (NOS) quality measurement tool. Meta-analysis of the extracted data was conducted using Stata 18. We also conducted sensitivity and subgroup analyses, as well as Begg's and Egger's tests.

Results

Twelve publications were involved in the analysis for prostate cancer, and six were included for ovary cancer. The outcomes indicated that PFOS exposure was positively related to prostate cancer (OR: 1.13, 95% CI: 1.00–1.28), while mixed PFAS exposure was positively related to ovarian cancer (OR: 1.63, 95% CI: 1.49–1.78). The source of heterogeneity identified in the subgroup analysis was primarily attributable to variations in study design. No significant study bias was detected in the analysis.

Conclusion

The study demonstrated an association between PFAS exposure and both prostate and ovarian cancers. Further investigation is required to clarify the underlying mechanisms and potential associations.

背景:全氟和多氟烷基物质(PFAS)是持久性环境污染物。先前的研究已经将PFAS暴露与前列腺癌和卵巢癌风险联系起来,然而,结论并不一致。本研究的目的是在人群水平上确定PFAS暴露与前列腺癌和卵巢癌之间的关系。方法:系统检索pubmed、Web of Science和embase三个数据库,从这些数据库建立到2024年4月15日。使用纽卡斯尔-渥太华量表(NOS)质量测量工具对所检索研究的质量进行评估。采用Stata 18对提取的数据进行meta分析。我们还进行了敏感性和亚组分析,以及贝格和埃格的测试。结果:12篇文献纳入前列腺癌的分析,6篇文献纳入卵巢癌的分析。结果表明,全氟辛烷磺酸暴露与前列腺癌呈正相关(OR: 1.13, 95% CI: 1.00-1.28),而混合全氟辛烷磺酸暴露与卵巢癌呈正相关(OR: 1.63, 95% CI: 1.49-1.78)。亚组分析中发现的异质性来源主要归因于研究设计的差异。分析中未发现显著的研究偏倚。结论:该研究表明PFAS暴露与前列腺癌和卵巢癌之间存在关联。需要进一步的调查来阐明潜在的机制和潜在的关联。
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引用次数: 0
Cover Image: Volume 68 Issue S1 封面图片:第68卷第S1期
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-28 DOI: 10.1002/ajim.23718

Cover Caption: Construction site workers, by wal_172619 via Pixabay.

封面说明:建筑工地工人,由wal_172619通过Pixabay。
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引用次数: 0
Work Participation in Patients With Carpal Tunnel Syndrome Referred to Departments of Occupational Medicine—A Danish Register-Based Cohort Study 职业医学系腕管综合征患者的工作参与情况——丹麦基于登记的队列研究
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-28 DOI: 10.1002/ajim.23716
Tine Hoffmann Aagaard, Karin Biering, Jesper Medom Vestergaard, Morten Vejs Willert, Marianne Kyndi

Background

We describe long-term work participation of patients with carpal tunnel syndrome (CTS) referred to Danish departments of occupational medicine and compare to patients with contact dermatitis.

Methods

One thousand seven hundred and sixty CTS-patients were included in this register-based nationwide longitudinal follow-up study and compared to 3158 contact dermatitis patients. We extracted register data on public benefits 5 years before and after assessment at a department of occupational medicine between 2000 and 2013. We defined a work participation score (WPS) as weeks where the patient was working divided by number of potential work weeks per year, dichotomized into low and high at the 75th percentile. We analyzed the risk of low WPS and of receiving permanent health-related public benefits during follow-up.

Results

Before assessment, both CTS and contact dermatitis patients had high work participation. In the follow-up period work participation decreased permanently for both patient groups. Comparing women with CTS to women with contact dermatitis, odds ratios (OR) of low WPS were 2.56 (2.11–3.11) and 1.68 (1.38–2.05) one and 5 years after assessment. For men, OR of low WPS were 2.01 (95% CI, 1.67–2.44) and 1.27 (95% CI, 1.04–1.56). ORs of receiving permanent health-related public benefits during follow-up were 2.10 (95% CI, 1.56–2.83) for men and 1.97 (95% CI, 1.54–2.54) for women with CTS compared to those with contact dermatitis.

Conclusions

Patients referred to Danish departments of occupational medicine due to CTS have increased risk of reduced long-term work participation and of receiving permanent health-related public benefits compared to patients referred due to contact dermatitis.

背景:我们描述了丹麦职业医学部门转诊的腕管综合征(CTS)患者长期参加工作的情况,并与接触性皮炎患者进行了比较:这项基于登记册的全国性纵向跟踪研究纳入了 1760 名 CTS 患者,并与 3158 名接触性皮炎患者进行了比较。我们提取了 2000 年至 2013 年期间在职业医学部门进行评估前后 5 年的公共福利登记数据。我们将工作参与评分(WPS)定义为患者的工作周数除以每年的潜在工作周数,以第75百分位数分为低分和高分。我们分析了低WPS风险和在随访期间领取永久性健康相关公共福利的风险:结果:在评估前,CTS 和接触性皮炎患者的工作参与度都很高。在随访期间,两组患者的工作参与率都出现了永久性下降。将患有 CTS 的妇女与患有接触性皮炎的妇女进行比较,在评估后 1 年和 5 年,低 WPS 的几率比(OR)分别为 2.56(2.11-3.11)和 1.68(1.38-2.05)。对于男性而言,WPS 低的几率比为 2.01(95% CI,1.67-2.44)和 1.27(95% CI,1.04-1.56)。与接触性皮炎患者相比,患有CTS的男性和女性在随访期间获得永久性健康相关公共福利的OR值分别为2.10(95% CI,1.56-2.83)和1.97(95% CI,1.54-2.54):结论:与因接触性皮炎转诊到丹麦职业医学科的患者相比,因CTS转诊到丹麦职业医学科的患者长期工作参与度降低和获得永久性健康相关公共福利的风险更高。
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引用次数: 0
Self-Reported Pesticide Application, Access to Pesticide Labels, and QR Code Use Among Agricultural H-2A Workers, North Carolina, 2024 农业H-2A工人自我报告的农药使用、农药标签获取和QR码使用,北卡罗来纳州,2024。
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-21 DOI: 10.1002/ajim.23712
Cesar Asuaje, Joseph G. L. Lee, Nowrin Nusrat, Lilibeth Andres, Natalie D. Rivera, Tania Connaughton-Espino, Paul Janampa, Catherine E. LePrevost

Background

Despite the composition of the United States' agricultural workforce and the sector's reliance on Spanish-speaking migrant labor, pesticide labels are largely available in English only. Currently, federal regulators are considering strategies to provide pesticide label information access in Spanish via a QR code or through other electronic methods on the pesticide container. Data on access to labels and the use of QR codes among agricultural workers are limited. We provide policy-relevant findings from surveys collected at a large agricultural worker H-2A visa arrival hub.

Methods

In April and May 2024, we verbally administered Spanish-language, in-person surveys in North Carolina (n = 160). We asked questions about pesticide use, access to labels, and QR code use as well as age, gender, and seasons worked in the United States.

Results

Descriptive analyses revealed approximately 60% of workers had not used a QR code. Among participants who had used pesticides and worked for two or more seasons (42%), approximately 30% reported not having access to the label on the container.

Conclusion

The survey findings show QR-code-based pesticide labels will reach a subset of workers, but substantial gaps will remain.

背景:尽管美国农业劳动力的构成和该部门对讲西班牙语的移民劳工的依赖,农药标签大多只有英文。目前,联邦监管机构正在考虑通过QR码或其他电子方法在农药容器上提供西班牙语农药标签信息。关于农业工人获得标签和使用二维码的数据有限。我们从一个大型农业工人H-2A签证到达中心收集的调查中提供了与政策相关的发现。方法:在2024年4月和5月,我们在北卡罗来纳州进行了口头西班牙语面对面调查(n = 160)。我们询问了有关农药使用、标签获取、QR码使用以及年龄、性别和在美国工作的季节的问题。结果:描述性分析显示,大约60%的员工没有使用QR码。在使用农药并工作了两个或两个以上季节的参与者中(42%),大约30%的人报告没有接触到容器上的标签。结论:调查结果显示,基于qr码的农药标签将覆盖一小部分工人,但仍存在很大差距。
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引用次数: 0
Blunted Blood Pressure Dipping During Night Shift Work: Does It Matter? Can We Intervene? 夜班工作时血压下降迟钝:这有关系吗?我们可以干预吗?
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-15 DOI: 10.1002/ajim.23711
P. Daniel Patterson, David Hostler, Matthew F. Muldoon, Daniel J. Buysse, Steven E. Reis

Cardiovascular disease (CVD) is the leading cause of adult death in the United States. Numerous studies show that night shift workers face a disproportionately higher risk of CVD compared to non-shift workers. Despite these data, the scientific and medical communities have not identified the physiological mechanisms that contribute to increased CVD risks for night shift workers. We propose that repetitive exposure to blunted blood pressure (BP) dipping associated with sleep loss during night shift work is an important, clinically meaningful, understudied, and modifiable contributor to increased risk of CVD. Blunted BP dipping occurs when BP fails to decrease or “dip” 10%−20% during nighttime hours (typically while sleeping) relative to daytime hours (typically while awake). Blunted BP dipping is widely considered a clinically meaningful indicator of poor cardiovascular health. Previous research suggests it is a common consequence of night shift work and occurs during sleep before and immediately after night shifts. Relatively few studies of shift work and CVD have focused on blunted BP dipping as a mechanism of CVD risk. Recent experimental research shows that restoration of normal BP patterns—during night shift work—is achievable with strategic napping and may reduce the risk of CVD. We present a series of important mechanistic-related questions and next steps for future research focused on blunted BP dipping and night shift work.

心血管疾病(CVD)是美国成年人死亡的主要原因。大量研究表明,夜班工人比非夜班工人患心血管疾病的风险高得多。尽管有这些数据,科学界和医学界还没有确定导致夜班工人心血管疾病风险增加的生理机制。我们认为,夜班工作期间反复暴露于与睡眠不足相关的钝性血压(BP)下降是CVD风险增加的一个重要的、临床意义的、研究不足的、可改变的因素。当血压在夜间(通常是在睡觉时)相对于白天(通常是在醒着的时候)没有下降或“下降”10%-20%时,就会发生钝化的血压下降。钝性血压下降被广泛认为是心血管健康状况不佳的临床有意义的指标。先前的研究表明,这是夜班工作的常见后果,发生在夜班前和夜班后的睡眠中。相对较少的倒班工作和心血管疾病的研究集中在钝性血压下降作为心血管疾病风险的机制。最近的实验研究表明,恢复正常的血压模式——在夜班工作期间——可以通过有策略的午睡来实现,并可能降低心血管疾病的风险。我们提出了一系列重要的机械相关问题和未来研究的下一步,重点是钝化BP和夜班工作。
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引用次数: 0
Enhancing the Psychosocial Hierarchy of Controls: Contextual, Sequential, and Integrated Approaches for Workplace Mental Health 加强控制的社会心理层次:工作场所心理健康的情境、顺序和综合方法。
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 DOI: 10.1002/ajim.23709
San-Ping Wang, Lien-Chung Wei
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引用次数: 0
Response to Enhancing the Psychosocial Hierarchy of Controls: Contextual, Sequential, and Integrated Approaches for Workplace Mental Health 对加强控制的社会心理层次的反应:工作场所心理健康的情境、顺序和综合方法。
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 DOI: 10.1002/ajim.23710
Asta Kjærgaard, Emilie M. Rudolf, Julie Palmqvist, Mikala E. Jakobsen, Jeppe Z. Nguyen Ajslev
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引用次数: 0
Foreword: Progress in Construction Safety and Health 前言:建筑安全与健康研究进展。
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-01-28 DOI: 10.1002/ajim.23708
Knut Ringen, Karl-Heinz Noetel, Krishna N. Sen, Miles Fisher

The construction industry has always been a large economic sector that is very hazardous to work in. Over the past 40 years there have been major improvements in safety and health practices driven by increased research and more rapid adoption of best practices, not just in the developed countries but also in emerging economies. This special issue aims to showcase a spectrum of perspectives from research to practice, about the current state of construction safety and health.

建筑业一直是一个很大的经济部门,工作起来非常危险。在过去40年里,不仅在发达国家,而且在新兴经济体,由于研究的增加和最佳做法的更迅速采用,安全和卫生做法取得了重大进展。本期特刊旨在展示从研究到实践的一系列观点,探讨建筑安全与健康的现状。
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引用次数: 0
Innovation Leading to Improved Safety, Health, and Productivity Is Enabled by Close Collaboration Between Construction Companies and Technology Start-Ups 通过建筑公司与科技初创企业的密切合作,创新可以改善安全、健康和生产力。
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-01-28 DOI: 10.1002/ajim.23702
Melike Yildiz, Stéphanie Bigeon-Bienvenu

The transfer of innovation to practice is one of the fundamental challenges of efficient social advancement. Because of its structure, with mostly small employers with limited working capital and short-term thinking arising from working on time-limited projects, historically the construction industry has been a slow adopter of technological advances. Now it is faced with a barrage of new technologies that not only can help solve some of the most pressing occupational safety and health needs but at the same time also contribute to productivity improvements. To address this, we—and others—have been finding ways to bring together tech start-ups and their innovations with construction companies who are willing to put them to use. We present four examples to illustrate how this can be accomplished and discuss the lessons we have learned in doing so.

将创新转化为实践是高效社会进步的基本挑战之一。由于其结构,大多数小雇主的流动资金有限,并且由于工作时间有限的项目而产生的短期思维,从历史上看,建筑业一直是技术进步的缓慢采纳者。现在,它面临着大量的新技术,这些新技术不仅可以帮助解决一些最紧迫的职业安全和健康需求,同时还有助于提高生产率。为了解决这个问题,我们和其他人一直在寻找方法,将科技初创企业及其创新与愿意将其投入使用的建筑公司结合起来。我们将提供四个示例来说明如何实现这一点,并讨论我们在此过程中吸取的经验教训。
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引用次数: 0
Incidence of Occupational Injuries Among Military Working Dog Handlers, 2016–2023 2016-2023年军事工作犬训导员职业伤害发生率
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-01-26 DOI: 10.1002/ajim.23707
Sithembile L. Mabila, Jessica H. Murray, Shauna L. Stahlman, Alexis A. McQuistan, Edward A. Sheriff

Objective

This study examines the incidence of injuries among active component service members in Military Working Dog (MWD) handler occupations compared to three other active component occupational groups.

Methods

A retrospective cohort study was conducted with a total of 2,524,092 active component service members including, 3935 MWD handlers, 2025 veterinary personnel, 113,413 military police, and 2,404,719 all other active component service members (ACSM). Incidence rate and incident rate ratios of injuries were determined.

Results

MWD handlers had the second highest rates of injuries (14,194.42 injuries per 10,000 p-yrs.) with veterinary personnel having the highest rate of injuries (17,320.11 injuries per 10,000 p-yrs.). Military police (11,521.71 injuries per 10,000 p-yrs.) and other ACSM (11,708.60 injuries per 10,000 p-yrs.) had similar incidence rates. Risk for injury was highest among women and older service members.

Conclusion

This study is among the first investigations into MWD handlers' occupational health outcomes. These results suggest the importance of continued MWD handler health assessment.

目的:本研究比较了军事工作犬(MWD)训导员职业中现役军人的伤害发生率,并与其他三个现役军人职业群体进行了比较。方法:采用回顾性队列研究方法,共纳入现役军人2,524,092人,其中MWD处理人员3935人,兽医人员2025人,宪兵113,413人,其他现役军人(ACSM) 2,404,719人。测定损伤发生率和事故率比。结果:MWD处理人员的伤害率第二高(14,194.42伤害/ 10,000 p-年),兽医人员的伤害率最高(17,320.11伤害/ 10,000 p-年)。宪兵(11,521.71人每10,000 p年受伤)和其他ACSM(11,708.60人每10,000 p年受伤)的发生率相似。受伤的风险在女性和老年服役人员中最高。结论:本研究是第一次对MWD操作人员的职业健康结果进行调查。这些结果表明持续进行随钻作业人员健康评估的重要性。
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引用次数: 0
期刊
American journal of industrial medicine
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