Claudia Corwin MD, MPH, Hillary Waterhouse MPH, CIH, CPH, Jerrold L. Abraham MD, Soma Sanyal MD, Judith A. Crawford PhD, CIH, Matthew Caddell DO, MPH, Michael J. Hodgson MD, MPH
Exposure to aluminum compounds is clearly associated with pulmonary function decrements, and several animal models document possible mechanisms of aluminum- compound-induced pulmonary toxicity. Nevertheless, disagreements remain about the precise mechanism by which exposures lead to damage. We present a strong case for attributing a case of interstitial pulmonary disease to occupational exposure to aluminum trihydrate. This report follows a 2014 publication of another case of interstitial pulmonary disease following a similar exposure. Our patient eventually underwent double lung transplantation nearly 5 years postexposure. Detailed pulmonary particulate elemental analysis suggested that aluminum metal, including aluminum trihydrate, was the most likely cause. A detailed assessment of the worker's relevant occupational exposures accompanies this case report.
{"title":"Interstitial pulmonary disease and aluminum trihydrate exposure: A single case report and detailed workplace analysis","authors":"Claudia Corwin MD, MPH, Hillary Waterhouse MPH, CIH, CPH, Jerrold L. Abraham MD, Soma Sanyal MD, Judith A. Crawford PhD, CIH, Matthew Caddell DO, MPH, Michael J. Hodgson MD, MPH","doi":"10.1002/ajim.23564","DOIUrl":"10.1002/ajim.23564","url":null,"abstract":"<p>Exposure to aluminum compounds is clearly associated with pulmonary function decrements, and several animal models document possible mechanisms of aluminum- compound-induced pulmonary toxicity. Nevertheless, disagreements remain about the precise mechanism by which exposures lead to damage. We present a strong case for attributing a case of interstitial pulmonary disease to occupational exposure to aluminum trihydrate. This report follows a 2014 publication of another case of interstitial pulmonary disease following a similar exposure. Our patient eventually underwent double lung transplantation nearly 5 years postexposure. Detailed pulmonary particulate elemental analysis suggested that aluminum metal, including aluminum trihydrate, was the most likely cause. A detailed assessment of the worker's relevant occupational exposures accompanies this case report.</p>","PeriodicalId":7873,"journal":{"name":"American journal of industrial medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajim.23564","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139519263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chelsea L. Martin, Morgan Richey, David B. Richardson, Maryalice Nocera, John Cantrell, Elizabeth S. McClure, Amelia T. Martin, Stephen W. Marshall, Shabbar I. Ranapurwala