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Determining Thresholds for Computer-Aided Detection for Silicosis—An Analytic Approach 确定计算机辅助检测矽肺病的阈值-一种分析方法。
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-04-06 DOI: 10.1002/ajim.23720
Stephen Barker, Annalee Yassi, Jerry Spiegel, Barry Kistnasamy, Rodney Ehrlich

Background

Computer-aided detection (CAD) is emerging as an adjunct to the use of the chest X-ray (CXR) in screening for pulmonary tuberculosis (TB). CAD for silicosis, a fibrotic lung disease due to silica dust and a strong risk factor for TB, is at an earlier stage of development and, unlike TB, depends on expert human reading for validation. For all CAD systems, an important step is the choice of threshold for classifying images as positive or negative for the disease in question. The objective of this article is to present an analytic approach to the choice of threshold in using CAD systems for silicosis.

Methods

Drawing on receiver operating curve data from a published study on agreement between CAD and two expert readings of silicosis, two criteria for choosing the sensitivity/specificity combination were compared—the Youden Index and a minimum sensitivity of 90%. We explore the impact of criterion selection, silicosis definition, and reader on the choice and interpretation of threshold, as well as the influence of positive predictive value (PPV) derived from screen prevalence. We present a novel technique for using two CAD thresholds to distinguish images with a high likelihood of being of positive or negative from those characterized by uncertainty.

Results

The sample was 501 CXR images from ex-gold miners. Derived thresholds varied across the two criteria, as well as across silicosis definition and expert reader. Varying the notional disease prevalence produced large differences in PPV and, therefore, proportions of false positives. The implications of these variations affecting threshold choice are described for three use cases—annual screening of active miners, outreach screening of former miners, and adjudication of claims for silicosis compensation.

Conclusion

In applying CAD to silicosis, users need to establish the use case, their preference for the sensitivity/specificity trade-off, and the silicosis definition, as well as considering the effect of disease prevalence. System developers need to take inter-reader variation in validation exercises into account and present this information transparently. A two-threshold model has potential utility in situations of high screening volume where there is a significant cost associated with referral for confirmation of diagnosis.

背景:计算机辅助检测(CAD)作为胸部x线(CXR)筛查肺结核(TB)的辅助手段正在兴起。矽肺病是一种由二氧化硅粉尘引起的纤维化肺病,是结核病的一个强大危险因素,其CAD尚处于早期发展阶段,与结核病不同,它依赖于专家的人类阅读来验证。对于所有CAD系统,一个重要的步骤是选择阈值,将图像分类为阳性或阴性的疾病。本文的目的是提出一种分析方法,以选择阈值在使用CAD系统的矽肺。方法:根据已发表的一项关于CAD与两份矽肺专家读数的一致性研究的受试者工作曲线数据,比较两种选择敏感性/特异性组合的标准——约登指数和最小灵敏度为90%。我们探讨了标准选择、矽肺定义和读者对阈值的选择和解释的影响,以及来自筛查患病率的阳性预测值(PPV)的影响。我们提出了一种新的技术,使用两个CAD阈值来区分具有高可能性的图像,从那些以不确定性为特征的阳性或阴性。结果:样本为前金矿工人的501张CXR图像。得出的阈值在两个标准之间,以及在矽肺定义和专家读者之间有所不同。不同的名义疾病流行率产生了PPV的巨大差异,因此,假阳性的比例。这些变化影响阈值选择的含义被描述为三个用例——在职矿工的年度筛选,前矿工的外联筛选,以及矽肺赔偿索赔的裁决。结论:在将CAD应用于矽肺病时,用户需要建立用例、对敏感性/特异性权衡的偏好、矽肺病的定义,并考虑疾病流行的影响。系统开发人员需要考虑验证练习中阅读器之间的差异,并透明地呈现这些信息。双阈值模型在高筛查量的情况下具有潜在的效用,其中转诊确认诊断的成本很高。
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引用次数: 0
Differences in the Effectiveness of Three OHS Training Delivery Methods 三种职业健康安全培训实施方式的有效性差异。
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-04-04 DOI: 10.1002/ajim.23719
Lynda S. Robson, Cynthia Chen, Cameron A. Mustard, Faraz Vahid Shahidi, Victoria Landsman, Peter M. Smith, Aviroop Biswas

Background

Methods of delivering occupational safety and health (OSH) training have shifted from in-person to online. Widespread delivery of a standardized OSH training course in three modalities in the province of Ontario, Canada allowed measurement of differences in their effectiveness.

Methods

Learners (N = 899) self-selected into face-to-face (F2F) instructor-led learning, online instructor-led synchronous distance learning, or online self-paced e-learning. Pre- and post-training surveys collected information on knowledge and other measures. Multiple regression analyses compared modalities on knowledge achievement (0%–100% scale; the primary outcome), engagement, perceived utility, perceived applicability, self-efficacy, and intention-to-use.

Results

F2F learners achieved a statistically significant 2.5% (95% CI: 0.3%, 4.7%) higher post-training knowledge score than distance learners (Cohen's d = 0.23, which is considered small). A statistically insignificant difference of 0.4% (95%: −1.4%, 2.3%) was seen between e-learners and distance learners. Collaborating training providers regarded these differences as not meaningful in practice. Statistically significant differences between modalities were seen for engagement, perceived utility, and self-efficacy. Scores of F2F learners were more favorable than scores of distance learners, which were, in turn, more favorable than scores of e-learners.

Conclusions

This study provides evidence that there are small to no differences among F2F, distance and e-learning in their ability to ensure knowledge achievement among learners. This finding is likely generalizable to other well-designed short-term OSH training aimed at acquiring new knowledge. More research is needed to understand whether there are important differences across these modalities in basic OHS skill acquisition and transfer of learning to the workplace.

背景:提供职业安全与健康(OSH)培训的方法已经从面对面转向在线。在加拿大安大略省以三种方式广泛提供标准化职业安全与卫生培训课程,可以衡量其有效性的差异。方法:学习者(N = 899)自行选择参加面对面(F2F)教师主导的学习,在线教师主导的同步远程学习或在线自定进度的电子学习。培训前后的调查收集了有关知识和其他措施的信息。多元回归分析比较知识成就的模式(0%-100%量表;主要结果)、参与、感知效用、感知适用性、自我效能和使用意图。结果:F2F学习者的培训后知识得分比远程学习者高2.5% (95% CI: 0.3%, 4.7%),具有统计学意义(Cohen’s d = 0.23,这被认为是小的)。在线学习者和远程学习者之间的差异在统计学上不显著,仅为0.4%(95%:-1.4%,2.3%)。合作培训提供者认为这些差异在实践中没有意义。在参与、感知效用和自我效能方面,不同模式之间存在统计学上的显著差异。F2F学习者的分数比远程学习者的分数更有利,而远程学习者的分数又比电子学习者的分数更有利。结论:本研究提供的证据表明,F2F、远程学习和电子学习在确保学习者知识成就的能力方面存在很小甚至没有差异。这一发现很可能推广到其他旨在获取新知识的精心设计的短期职业安全与健康培训。需要更多的研究来了解这些模式在职业健康安全基本技能获得和学习转移到工作场所方面是否存在重要差异。
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引用次数: 0
Gastroesophageal Reflux Disease in the World Trade Center Health Program General Responder Cohort 世界贸易中心健康计划一般应答者队列中的胃食管反流病
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-04-02 DOI: 10.1002/ajim.23721
Christopher R. Dasaro, Ahmad Sabra, Henry S. Sacks, Benjamin J. Luft, Denise J. Harrison, Iris G. Udasin, Michael A. Crane, Jacqueline M. Moline, Winston Kwa, Andrew C. Todd, Nancy L. Sloan, Susan L. Teitelbaum

Background

People participating in the rescue, recovery, and clean-up effort after the September 11, 2001 attack on the World Trade Center (WTC) were exposed to a complex mix of noxious substances and subsequently experienced elevated gastroesophageal reflux disease (GERD) incidence, the second-most-common WTC-related condition.

Methods

Longitudinal WTC Health Program data, collected between July 2002 and December 2022, were used to describe the sample characteristics, diagnostic procedures, and treatment of consenting cohort members with self-reported GERD who reported incident GERD for a year or longer (n = 19,067). Cross-tabulations and binomial logistic regression, adjusted for confounders including comorbidities, assessed the associations with intermittent and resolved, compared with unresolved, GERD.

Results

12.6% of the study cohort reported intermittent GERD; 5.5% reported GERD resolution. Analyses indicated that most GERD resolution was reported by people of color and those with body mass index <25, and by cohort members who had longer postdiagnosis follow-up and implemented dietary modifications together with proton pump inhibitors or Program-approved antacids. GERD-certified members who underwent endoscopy, used medications without dietary modifications, or used bed head-elevation, and those with Barrett's disease (5.8%) or esophageal cancer (0.1%) may have had more severe GERD and reported little resolution.

Conclusions

The use of GERD services was consistent with clinical guidelines. Members' implementing dietary modifications in conjunction with proton pump inhibitors or Program-approved antacids reported more resolution and may have had less severe GERD. Earlier diagnosis and intervention might increase earlier therapeutic resolution.

背景:2001年9月11日世界贸易中心(WTC)遇袭后,参与救援、恢复和清理工作的人们暴露于复杂的有毒物质混合物中,随后经历了胃食管反流病(GERD)发病率升高,这是世界贸易中心(WTC)相关的第二大常见疾病。方法:从2002年7月至2022年12月收集的纵向WTC健康计划数据用于描述样本特征、诊断程序和同意自报告发生GERD一年或更长时间的GERD队列成员的治疗(n = 19,067)。交叉表和二项逻辑回归,调整混杂因素,包括合并症,评估间歇性和消退性胃食管反流与未消退性胃食管反流的关系。结果:12.6%的研究队列报告间歇性胃食管反流;5.5%报告GERD解决。分析表明,有色人种和有体重指数的人报告了大多数胃食管反流的消退。结论:使用胃食管反流服务符合临床指南。与质子泵抑制剂或项目批准的抗酸剂一起实施饮食调整的成员报告了更多的解决方案,并且可能减轻了严重的胃反流。早期诊断和干预可能会增加早期治疗效果。
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引用次数: 0
Exposure to the World Trade Center Disaster, Health, and Health-Related Quality of Life Nearly 20 Years After 9/11 9/11事件后近20年的世界贸易中心灾难、健康和与健康相关的生活质量
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-04-02 DOI: 10.1002/ajim.23706
Julia S. Sisti, Ananya Dhanya, Howard E. Alper, Nicholas Millet, Ayda Ahmadi, Robert M. Brackbill

Background

Exposure to the terrorist attacks on the World Trade Center (WTC) on September 11, 2001, has been associated with several chronic physical and mental health conditions. We assessed the burden, nearly 20 years after the attacks, of several 9/11-related health conditions and indicators of poor health-related quality of life (HRQOL) among individuals exposed to the WTC disaster.

Methods

Among individuals enrolled in the longitudinal WTC Health Registry in 2020–2021 (N = 26,964), we estimated post-9/11 prevalence of: self-reported diagnosed physical health conditions known to be associated with WTC exposure; probable posttraumatic stress disorder (PTSD) and depression; and poor HRQOL indicators. We also compared lifetime prevalence of selected conditions and poor-HRQOL indicators among WTC-exposed rescue and recovery workers and community members, separately, to New York State general population estimates, using multivariable-adjusted logistic regression.

Results

Prevalence of post-9/11 physical health conditions ranged from 10.5% (chronic obstructive pulmonary disease, COPD) to 26.3% (gastroesophageal reflux disease). Prevalence of probable post-9/11 PTSD and depression were 9.6% and 12.7%, respectively. Lifetime prevalence of physician-diagnosed asthma, COPD, and depression were higher among WTC-exposed individuals compared to the general population. Indicators of poor HRQOL were higher among WTC Registry enrollees relative to the general population, and among enrollees with any physical or probable mental health conditions compared to enrollees without any conditions.

Conclusions

Nearly 20 years after 9/11, WTC-exposed populations experience a high burden of health conditions that affect their wellbeing, highlighting the need for continued monitoring of this population.

背景:暴露在2001年9月11日世界贸易中心(WTC)的恐怖袭击中,与几种慢性身心健康状况有关。我们评估了9/11事件发生近20年后,与9/11事件相关的几种健康状况和与健康相关的生活质量(HRQOL)指标在世贸中心灾难暴露人群中的负担。方法:在2020-2021年参加世贸中心纵向健康登记的个体中(N = 26,964),我们估计了911后的患病率:已知与世贸中心暴露相关的自我报告诊断的身体健康状况;可能的创伤后应激障碍(PTSD)和抑郁症;HRQOL指标差。我们还使用多变量调整logistic回归,分别比较了wtc暴露的救援和恢复工作者和社区成员中选择条件和不良hrqol指标的终生患病率与纽约州一般人群估计值。结果:9/11后身体健康状况的患病率从10.5%(慢性阻塞性肺疾病,COPD)到26.3%(胃食管反流病)不等。9/11后PTSD和抑郁症的患病率分别为9.6%和12.7%。与普通人群相比,wtc暴露个体中医生诊断的哮喘、COPD和抑郁症的终生患病率更高。WTC登记注册者的HRQOL差指标高于一般人群,有任何身体或可能的精神健康状况的注册者的HRQOL差指标高于没有任何健康状况的注册者。结论:9/11事件发生近20年后,wtc暴露人群经历了影响其健康状况的沉重负担,突出了对这一人群进行持续监测的必要性。
{"title":"Exposure to the World Trade Center Disaster, Health, and Health-Related Quality of Life Nearly 20 Years After 9/11","authors":"Julia S. Sisti,&nbsp;Ananya Dhanya,&nbsp;Howard E. Alper,&nbsp;Nicholas Millet,&nbsp;Ayda Ahmadi,&nbsp;Robert M. Brackbill","doi":"10.1002/ajim.23706","DOIUrl":"10.1002/ajim.23706","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Exposure to the terrorist attacks on the World Trade Center (WTC) on September 11, 2001, has been associated with several chronic physical and mental health conditions. We assessed the burden, nearly 20 years after the attacks, of several 9/11-related health conditions and indicators of poor health-related quality of life (HRQOL) among individuals exposed to the WTC disaster.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Among individuals enrolled in the longitudinal WTC Health Registry in 2020–2021 (<i>N</i> = 26,964), we estimated post-9/11 prevalence of: self-reported diagnosed physical health conditions known to be associated with WTC exposure; probable posttraumatic stress disorder (PTSD) and depression; and poor HRQOL indicators. We also compared lifetime prevalence of selected conditions and poor-HRQOL indicators among WTC-exposed rescue and recovery workers and community members, separately, to New York State general population estimates, using multivariable-adjusted logistic regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Prevalence of post-9/11 physical health conditions ranged from 10.5% (chronic obstructive pulmonary disease, COPD) to 26.3% (gastroesophageal reflux disease). Prevalence of probable post-9/11 PTSD and depression were 9.6% and 12.7%, respectively. Lifetime prevalence of physician-diagnosed asthma, COPD, and depression were higher among WTC-exposed individuals compared to the general population. Indicators of poor HRQOL were higher among WTC Registry enrollees relative to the general population, and among enrollees with any physical or probable mental health conditions compared to enrollees without any conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Nearly 20 years after 9/11, WTC-exposed populations experience a high burden of health conditions that affect their wellbeing, highlighting the need for continued monitoring of this population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7873,"journal":{"name":"American journal of industrial medicine","volume":"68 5","pages":"413-427"},"PeriodicalIF":2.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajim.23706","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Student and Parental Job Loss During the COVID-19 Public Health Emergency: Effects on Household Economic Security COVID-19突发公共卫生事件期间学生和家长失业:对家庭经济安全的影响
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-08 DOI: 10.1002/ajim.23713
Sharon R. Silver, Taylor M. Shockey, Jonetta J. Mpofu

Background

While studies have examined effects of parental job loss early in the COVID-19 pandemic, few have assessed economic impacts of student job loss.

Methods

The Adolescent Behaviors and Experiences Survey (ABES) was a one-time online, nationally-representative survey administered by CDC in 2021 to understand high school students' experiences. We assessed associations between student, parent, and dyadic employment experiences and two measures of economic stress: housing instability and food insufficiency.

Results

Parental job loss was common and associated with both adverse economic outcomes. The adjusted prevalence rate (aPR) for housing instability was 2.79, 95% confidence interval (CI) = 1.73–4.51. A new finding is that student employment may also play a role in food sufficiency. Student job loss was significantly associated with both any food insufficiency and frequent food insufficiency (aPR = 1.61, 95% CI = 1.35–1.93 and aPR = 1.96, 95% CI = 1.43–2.70, respectively).

Discussion

Analysis of associations between employment status before and during the COVID-19 public health emergency and measures of household economic insecurity reveals social safety net gaps. Our finding that student employment may affect household food sufficiency highlights the need to better understand the role of student employment in household economic stress.

背景:虽然有研究调查了COVID-19大流行早期父母失业的影响,但很少有研究评估学生失业的经济影响。方法:《青少年行为与经历调查》(ABES)是CDC于2021年实施的一项具有全国代表性的一次性在线调查,旨在了解高中生的经历。我们评估了学生、家长和二元就业经历与两项经济压力指标之间的联系:住房不稳定和食物不足。结果:父母失业是常见的,并且与不利的经济结果有关。住房不稳定的调整患病率(aPR)为2.79,95%可信区间(CI) = 1.73 ~ 4.51。一项新的发现是,学生就业也可能在食物充足方面发挥作用。学生失业与任何食物不足和频繁食物不足均显著相关(aPR = 1.61, 95% CI = 1.35-1.93, aPR = 1.96, 95% CI = 1.43-2.70)。讨论:分析2019冠状病毒病突发公共卫生事件之前和期间的就业状况与家庭经济不安全措施之间的关联,揭示社会安全网缺口。我们发现学生就业可能会影响家庭食物充足,这突出了更好地理解学生就业在家庭经济压力中的作用的必要性。
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引用次数: 0
Reliability and Validity of the Japanese Version of the Four-Item Psychosocial Safety Climate Scale (PSC-4J) 日本版心理社会安全气候量表(PSC-4J)的信度和效度
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-05 DOI: 10.1002/ajim.23715
Akiomi Inoue, Hisashi Eguchi, Yuko Kachi, Maureen F. Dollard, Akizumi Tsutsumi

Background

Short measurement scales are increasingly sought-after for reasons of efficiency and survey fatigue. A short four-item measure of an organization's climate for employee psychological health, the psychosocial safety climate (PSC-4), has gained international usage. However, the psychometric properties of its Japanese version (PSC-4J) are unknown. We examined the reliability and validity of the PSC-4J.

Methods

An online survey containing the Japanese 12-item PSC scale (PSC-12J), from which the PSC-4J derived, and relevant variables (job demands, job resources, and outcomes) was administered to 2200 employees registered with a Japanese online survey provider. Two weeks later, the PSC-12J was measured again with a follow-up survey of 1400 respondents. Internal consistency and test-retest reliability were examined by Cronbach's α and intraclass correlation (ICC). Agreement between PSC-4J and PSC-12J was examined by Spearman's correlation. Structural validity was examined by confirmatory factor analysis (CFA) and item response theory (IRT) analysis. Convergent validity was examined by Spearman's correlations of PSC-4J with relevant variables, comparing these results with the PSC-12J.

Results

Cronbach's α and ICC for PSC-4J were 0.91 and 0.68, respectively. Spearman's correlation between PSC-4J and PSC-12J was 0.97. The CFA assuming a one-factor structure showed good model fit. The IRT analysis indicated each PSC-4J item had very high discrimination and appropriate difficulty. Spearman's correlations of PSC-4J with relevant variables were slightly lower than for PSC-12J but in the theoretically expected direction.

Conclusions

The PSC-4J, while slightly inferior to the PSC-12J in psychometric properties, provides comparable measurements with fewer items while maintaining adequate reliability and validity.

背景:由于效率和调查疲劳的原因,短测量量表越来越受欢迎。社会心理安全气候(PSC-4)是衡量组织员工心理健康气候的一个简短的四项指标,已在国际上得到使用。然而,其日文版本(PSC-4J)的心理测量特性尚不清楚。我们检查了PSC-4J的可靠性和有效性。方法:采用日语12题PSC量表(PSC- 12j)和相关变量(工作需求、工作资源和结果)对在日本在线调查提供商注册的2200名员工进行在线调查,PSC- 4j由此衍生。两周后,又对1400名受访者进行了PSC-12J测试。采用Cronbach’s α和类内相关(ICC)检验内部一致性和重测信度。PSC-4J和PSC-12J的一致性采用Spearman相关检验。采用验证性因子分析(CFA)和项目反应理论(IRT)检验结构效度。通过PSC-4J与相关变量的Spearman相关性来检验收敛效度,并将这些结果与PSC-12J进行比较。结果:PSC-4J的Cronbach’s α和ICC分别为0.91和0.68。PSC-4J与PSC-12J的Spearman相关系数为0.97。假设单因素结构的CFA显示出良好的模型拟合。IRT分析显示PSC-4J的每个条目具有很高的辨识度和适当的难度。PSC-4J与相关变量的Spearman相关性略低于PSC-12J,但符合理论预期方向。结论:PSC-4J虽然在心理测量特性上略低于PSC-12J,但在保持足够信度和效度的同时,提供了较少项目的可比较测量。
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引用次数: 0
Exposure to Per- and Polyfluoroalkyl Substances and the Risk of Prostate and Ovarian Cancer: An Epidemiologic Meta-Analysis 暴露于全氟和多氟烷基物质与前列腺癌和卵巢癌的风险:一项流行病学荟萃分析。
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-05 DOI: 10.1002/ajim.23717
Shenglan Yang, Hui Dong, Xinyu Gou, Limei Chen, Ying Zhang, Jing Wu

Background

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants. Previous research has linked PFAS exposure to prostate and ovarian cancer risk, however, the conclusions have been inconsistent. This research purpose was to determine the relationship between PFAS exposure and prostate and ovarian cancer at the population level.

Methods

We systematically reviewed three databases—PubMed, Web of Science, and Embase—for research from when these databases were established to April 15, 2024. The quality of the retrieved research was evaluated using the Newcastle-Ottawa Scale (NOS) quality measurement tool. Meta-analysis of the extracted data was conducted using Stata 18. We also conducted sensitivity and subgroup analyses, as well as Begg's and Egger's tests.

Results

Twelve publications were involved in the analysis for prostate cancer, and six were included for ovary cancer. The outcomes indicated that PFOS exposure was positively related to prostate cancer (OR: 1.13, 95% CI: 1.00–1.28), while mixed PFAS exposure was positively related to ovarian cancer (OR: 1.63, 95% CI: 1.49–1.78). The source of heterogeneity identified in the subgroup analysis was primarily attributable to variations in study design. No significant study bias was detected in the analysis.

Conclusion

The study demonstrated an association between PFAS exposure and both prostate and ovarian cancers. Further investigation is required to clarify the underlying mechanisms and potential associations.

背景:全氟和多氟烷基物质(PFAS)是持久性环境污染物。先前的研究已经将PFAS暴露与前列腺癌和卵巢癌风险联系起来,然而,结论并不一致。本研究的目的是在人群水平上确定PFAS暴露与前列腺癌和卵巢癌之间的关系。方法:系统检索pubmed、Web of Science和embase三个数据库,从这些数据库建立到2024年4月15日。使用纽卡斯尔-渥太华量表(NOS)质量测量工具对所检索研究的质量进行评估。采用Stata 18对提取的数据进行meta分析。我们还进行了敏感性和亚组分析,以及贝格和埃格的测试。结果:12篇文献纳入前列腺癌的分析,6篇文献纳入卵巢癌的分析。结果表明,全氟辛烷磺酸暴露与前列腺癌呈正相关(OR: 1.13, 95% CI: 1.00-1.28),而混合全氟辛烷磺酸暴露与卵巢癌呈正相关(OR: 1.63, 95% CI: 1.49-1.78)。亚组分析中发现的异质性来源主要归因于研究设计的差异。分析中未发现显著的研究偏倚。结论:该研究表明PFAS暴露与前列腺癌和卵巢癌之间存在关联。需要进一步的调查来阐明潜在的机制和潜在的关联。
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引用次数: 0
Cover Image: Volume 68 Issue S1 封面图片:第68卷第S1期
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-28 DOI: 10.1002/ajim.23718

Cover Caption: Construction site workers, by wal_172619 via Pixabay.

封面说明:建筑工地工人,由wal_172619通过Pixabay。
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引用次数: 0
Work Participation in Patients With Carpal Tunnel Syndrome Referred to Departments of Occupational Medicine—A Danish Register-Based Cohort Study 职业医学系腕管综合征患者的工作参与情况——丹麦基于登记的队列研究
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-28 DOI: 10.1002/ajim.23716
Tine Hoffmann Aagaard, Karin Biering, Jesper Medom Vestergaard, Morten Vejs Willert, Marianne Kyndi

Background

We describe long-term work participation of patients with carpal tunnel syndrome (CTS) referred to Danish departments of occupational medicine and compare to patients with contact dermatitis.

Methods

One thousand seven hundred and sixty CTS-patients were included in this register-based nationwide longitudinal follow-up study and compared to 3158 contact dermatitis patients. We extracted register data on public benefits 5 years before and after assessment at a department of occupational medicine between 2000 and 2013. We defined a work participation score (WPS) as weeks where the patient was working divided by number of potential work weeks per year, dichotomized into low and high at the 75th percentile. We analyzed the risk of low WPS and of receiving permanent health-related public benefits during follow-up.

Results

Before assessment, both CTS and contact dermatitis patients had high work participation. In the follow-up period work participation decreased permanently for both patient groups. Comparing women with CTS to women with contact dermatitis, odds ratios (OR) of low WPS were 2.56 (2.11–3.11) and 1.68 (1.38–2.05) one and 5 years after assessment. For men, OR of low WPS were 2.01 (95% CI, 1.67–2.44) and 1.27 (95% CI, 1.04–1.56). ORs of receiving permanent health-related public benefits during follow-up were 2.10 (95% CI, 1.56–2.83) for men and 1.97 (95% CI, 1.54–2.54) for women with CTS compared to those with contact dermatitis.

Conclusions

Patients referred to Danish departments of occupational medicine due to CTS have increased risk of reduced long-term work participation and of receiving permanent health-related public benefits compared to patients referred due to contact dermatitis.

背景:我们描述了丹麦职业医学部门转诊的腕管综合征(CTS)患者长期参加工作的情况,并与接触性皮炎患者进行了比较:这项基于登记册的全国性纵向跟踪研究纳入了 1760 名 CTS 患者,并与 3158 名接触性皮炎患者进行了比较。我们提取了 2000 年至 2013 年期间在职业医学部门进行评估前后 5 年的公共福利登记数据。我们将工作参与评分(WPS)定义为患者的工作周数除以每年的潜在工作周数,以第75百分位数分为低分和高分。我们分析了低WPS风险和在随访期间领取永久性健康相关公共福利的风险:结果:在评估前,CTS 和接触性皮炎患者的工作参与度都很高。在随访期间,两组患者的工作参与率都出现了永久性下降。将患有 CTS 的妇女与患有接触性皮炎的妇女进行比较,在评估后 1 年和 5 年,低 WPS 的几率比(OR)分别为 2.56(2.11-3.11)和 1.68(1.38-2.05)。对于男性而言,WPS 低的几率比为 2.01(95% CI,1.67-2.44)和 1.27(95% CI,1.04-1.56)。与接触性皮炎患者相比,患有CTS的男性和女性在随访期间获得永久性健康相关公共福利的OR值分别为2.10(95% CI,1.56-2.83)和1.97(95% CI,1.54-2.54):结论:与因接触性皮炎转诊到丹麦职业医学科的患者相比,因CTS转诊到丹麦职业医学科的患者长期工作参与度降低和获得永久性健康相关公共福利的风险更高。
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引用次数: 0
Self-Reported Pesticide Application, Access to Pesticide Labels, and QR Code Use Among Agricultural H-2A Workers, North Carolina, 2024 农业H-2A工人自我报告的农药使用、农药标签获取和QR码使用,北卡罗来纳州,2024。
IF 2.7 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-21 DOI: 10.1002/ajim.23712
Cesar Asuaje, Joseph G. L. Lee, Nowrin Nusrat, Lilibeth Andres, Natalie D. Rivera, Tania Connaughton-Espino, Paul Janampa, Catherine E. LePrevost

Background

Despite the composition of the United States' agricultural workforce and the sector's reliance on Spanish-speaking migrant labor, pesticide labels are largely available in English only. Currently, federal regulators are considering strategies to provide pesticide label information access in Spanish via a QR code or through other electronic methods on the pesticide container. Data on access to labels and the use of QR codes among agricultural workers are limited. We provide policy-relevant findings from surveys collected at a large agricultural worker H-2A visa arrival hub.

Methods

In April and May 2024, we verbally administered Spanish-language, in-person surveys in North Carolina (n = 160). We asked questions about pesticide use, access to labels, and QR code use as well as age, gender, and seasons worked in the United States.

Results

Descriptive analyses revealed approximately 60% of workers had not used a QR code. Among participants who had used pesticides and worked for two or more seasons (42%), approximately 30% reported not having access to the label on the container.

Conclusion

The survey findings show QR-code-based pesticide labels will reach a subset of workers, but substantial gaps will remain.

背景:尽管美国农业劳动力的构成和该部门对讲西班牙语的移民劳工的依赖,农药标签大多只有英文。目前,联邦监管机构正在考虑通过QR码或其他电子方法在农药容器上提供西班牙语农药标签信息。关于农业工人获得标签和使用二维码的数据有限。我们从一个大型农业工人H-2A签证到达中心收集的调查中提供了与政策相关的发现。方法:在2024年4月和5月,我们在北卡罗来纳州进行了口头西班牙语面对面调查(n = 160)。我们询问了有关农药使用、标签获取、QR码使用以及年龄、性别和在美国工作的季节的问题。结果:描述性分析显示,大约60%的员工没有使用QR码。在使用农药并工作了两个或两个以上季节的参与者中(42%),大约30%的人报告没有接触到容器上的标签。结论:调查结果显示,基于qr码的农药标签将覆盖一小部分工人,但仍存在很大差距。
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引用次数: 0
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American journal of industrial medicine
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