Pub Date : 2018-06-30DOI: 10.18413/2075-4728-2018-41-2-214-219
I. O. Zhukova, O. Lebedeva, O. Ivashova, S. P. Pakhomov, M. Churnosov
The article is devoted to expression of clusters differentiation of T-lymphocytes in endometium of patients with spontaneous and missed abortions in 6-10 weeks of gestation. 34 patients with missed abortion, 34 – with miscarriages and 57 patients with progressive pregnancy of the same gestational age, ad-mitted for medical abortion (control group) were studied. Endometrium was obtained during uterine abra-sion. Expression of CD4, CD8 and CD25 mRNA was studied by quantitative PCR. Expression was counted as delta-delta cq. Statistical analysis was pefrormed using Mann-Whitney criteria. No significant differences of CD4 and CD8 expression was detected in patients with missed abortion and spontaneous miscarriages compared with control group. CD25 mRNA expression was significantly higher in patients with missed abortions. As CD25 is a marker of activated lymphocytes, it can be suggested, that this in-crease can stimulate reactions of cell cytotoxicity and therefore contribute to demise of embryo. Ключевые слова: невынашивание, самопроизвольный выкидыш, неразвивающаяся беременность, эндометрий, CD4, CD8, CD25, Т-лимфоциты. role chori-onic gonadotropin in modulation of functional acidity of naïve T-cells and immune memory T-cells]. signalizacija: statej Mezhdunarodnoj intracellular signaling: В.А., Н.А., Агад-жанова А.А., 2017.
{"title":"CD4+ AND CD8+ T-lymphocytes in endometrium and their role in early stage miscarriages","authors":"I. O. Zhukova, O. Lebedeva, O. Ivashova, S. P. Pakhomov, M. Churnosov","doi":"10.18413/2075-4728-2018-41-2-214-219","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-2-214-219","url":null,"abstract":"The article is devoted to expression of clusters differentiation of T-lymphocytes in endometium of patients with spontaneous and missed abortions in 6-10 weeks of gestation. 34 patients with missed abortion, 34 – with miscarriages and 57 patients with progressive pregnancy of the same gestational age, ad-mitted for medical abortion (control group) were studied. Endometrium was obtained during uterine abra-sion. Expression of CD4, CD8 and CD25 mRNA was studied by quantitative PCR. Expression was counted as delta-delta cq. Statistical analysis was pefrormed using Mann-Whitney criteria. No significant differences of CD4 and CD8 expression was detected in patients with missed abortion and spontaneous miscarriages compared with control group. CD25 mRNA expression was significantly higher in patients with missed abortions. As CD25 is a marker of activated lymphocytes, it can be suggested, that this in-crease can stimulate reactions of cell cytotoxicity and therefore contribute to demise of embryo. Ключевые слова: невынашивание, самопроизвольный выкидыш, неразвивающаяся беременность, эндометрий, CD4, CD8, CD25, Т-лимфоциты. role chori-onic gonadotropin in modulation of functional acidity of naïve T-cells and immune memory T-cells]. signalizacija: statej Mezhdunarodnoj intracellular signaling: В.А., Н.А., Агад-жанова А.А., 2017.","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82909594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-30DOI: 10.18413/2075-4728-2018-41-2-327-337
V. V. Sukhodolskaya
In the article discusses some aspects of the problem of tuberculosis and its prophylaxis on children. The main components of the World TB Control Program are timely detection and treatment of patients, prevention in persons at risk. It has been established that the main tool for preventing the disease is vaccination with the most effective vaccine against tuberculosis BCG. According to a number of available foreign literature sources summarize the information on BCG vaccination and its complications. Shows the bridging role between the development of adverse reactions and complications after BCG vaccination and various factors related both to the BCG vaccine and to the recipient. The statistics of complications after BCG vaccination was analyzed. It was concluded that the most common complication of BCG vaccination is regional lymphadenitis. Difficulties in the diagnosis of BCG-associated lymphadenitis have been studied. Despite a significant number of studies conducted to study the factors contributing to the development of BCG-associated lymphadenitis, some of them are still not fully understood. The question is: when and how to use the BCG vaccine to avoid complications, remains controversial, which determines the relevance of further research in this area. Ключевые слова: туберкулез, дети, вакцина БЦЖ, осложнения, лимфадениты.
{"title":"Some aspects of the problem of prevention of tuberculosis children of early age (review of foreign literature)","authors":"V. V. Sukhodolskaya","doi":"10.18413/2075-4728-2018-41-2-327-337","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-2-327-337","url":null,"abstract":"In the article discusses some aspects of the problem of tuberculosis and its prophylaxis on children. The main components of the World TB Control Program are timely detection and treatment of patients, prevention in persons at risk. It has been established that the main tool for preventing the disease is vaccination with the most effective vaccine against tuberculosis BCG. According to a number of available foreign literature sources summarize the information on BCG vaccination and its complications. Shows the bridging role between the development of adverse reactions and complications after BCG vaccination and various factors related both to the BCG vaccine and to the recipient. The statistics of complications after BCG vaccination was analyzed. It was concluded that the most common complication of BCG vaccination is regional lymphadenitis. Difficulties in the diagnosis of BCG-associated lymphadenitis have been studied. Despite a significant number of studies conducted to study the factors contributing to the development of BCG-associated lymphadenitis, some of them are still not fully understood. The question is: when and how to use the BCG vaccine to avoid complications, remains controversial, which determines the relevance of further research in this area. Ключевые слова: туберкулез, дети, вакцина БЦЖ, осложнения, лимфадениты.","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83502930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-30DOI: 10.18413/2075-4728-2018-41-2-205-213
E. Bryksina, A. Pochivalov, V. Bryksin
One of the most frequent infectious diseases in nosological structure of the neonatal period is pneumonia. The newborns who are on the artificial pulmonary ventilation (APV) get into risk group on development the ventilator-associated pneumonia (VAP) which frequency increases in process of increase in duration of APV. It is established, that newborns, being on APV in most cases have a microaspiration of gastric contents that does relevant the purpose of the real research: studying of influence of APV and a microaspiration of gastric contents on the frequency of development and feature of a course of neonatal pneumonia. Materials and methods. The research included 177 newborns receiving respiratory therapy. The ex-pressiveness of a microaspiration was estimated on the basis of definition of Pepsinum in a tracheobron-chial aspirate (TBA). The diagnosis of VAP was established on the basis of reference clinical and radio-logical criteria. Main results of a research. It is established that the newborns who are on the APV with "rigid" parameters had more frequent cases of pneumonia with the expressed microaspiration of gastric contents. Patients with a combination of a microaspiration and pneumonia had the maximal duration the APV and the subsequent kislorodoterapiya. In a genesis of heavy respiratory frustration in the neonatal period with requirement in the APV with "rigid" parameters contamination of respiratory tracts a Gram-negative microflora, presumably intestinal origin had the greatest statistical
{"title":"Infiuence of parameters of artificial pulmonary ventilation and microaspiration of gastric contents on the frequency of development of neonatal pneumonia","authors":"E. Bryksina, A. Pochivalov, V. Bryksin","doi":"10.18413/2075-4728-2018-41-2-205-213","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-2-205-213","url":null,"abstract":"One of the most frequent infectious diseases in nosological structure of the neonatal period is pneumonia. The newborns who are on the artificial pulmonary ventilation (APV) get into risk group on development the ventilator-associated pneumonia (VAP) which frequency increases in process of increase in duration of APV. It is established, that newborns, being on APV in most cases have a microaspiration of gastric contents that does relevant the purpose of the real research: studying of influence of APV and a microaspiration of gastric contents on the frequency of development and feature of a course of neonatal pneumonia. Materials and methods. The research included 177 newborns receiving respiratory therapy. The ex-pressiveness of a microaspiration was estimated on the basis of definition of Pepsinum in a tracheobron-chial aspirate (TBA). The diagnosis of VAP was established on the basis of reference clinical and radio-logical criteria. Main results of a research. It is established that the newborns who are on the APV with \"rigid\" parameters had more frequent cases of pneumonia with the expressed microaspiration of gastric contents. Patients with a combination of a microaspiration and pneumonia had the maximal duration the APV and the subsequent kislorodoterapiya. In a genesis of heavy respiratory frustration in the neonatal period with requirement in the APV with \"rigid\" parameters contamination of respiratory tracts a Gram-negative microflora, presumably intestinal origin had the greatest statistical","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85458144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-30DOI: 10.18413/2075-4728-2018-41-2-288-296
O. Efremova, N. I. Golovina, M. A. Krivoruchenko, L. A. Кamyshnikova
Rheumatoid arthritis is a systemic disease of unclear etiology with autoimmune pathogenesis, which is characterized by chronic erosive polyarthritis. In some patients with rheumatoid arthritis, there is a dis-crepancy between the processes of bone resorption and bone formation, which is the cause of secondary metabolic osteopathy. A complication of rheumatoid arthritis with a change in bone quality is osteoporosis. Reduced bone density and an increased risk of fractures in osteoporosis determine the adverse course and significantly worsen the prognosis of the disease. IHD in combination with rheumatoid arthritis ag-gravates risk factors, leading to a decrease in bone density and an increased risk of fractures in osteoporosis, which determines the unfavorable course and significantly worsens the prognosis of the disease. At the present time, a number of studies the association of an increased risk of osteoporosis with the pres-ence of the following factors in patients with IHD in combination with rheumatoid arthritis has been re-vealed: low bone mineral density, female sex, age 65 years, early menopause, weight less than 57 kg, family history of osteoporosis, previous fractures, prolonged the course of rheumatoid arthritis and irra-tional therapy with glucocorticosteroids. This article presents the results of an analysis of the factors that lead to the development of osteoporosis in patients with ischemic heart disease in combination with rheumatoid arthritis who are inpatient treatment in the rheumatological department. сердечно-сосудистые
{"title":"Factors leading to the development of osteoporosis in patients with ischemic heart disease in combination with rheumatoid arthritis","authors":"O. Efremova, N. I. Golovina, M. A. Krivoruchenko, L. A. Кamyshnikova","doi":"10.18413/2075-4728-2018-41-2-288-296","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-2-288-296","url":null,"abstract":"Rheumatoid arthritis is a systemic disease of unclear etiology with autoimmune pathogenesis, which is characterized by chronic erosive polyarthritis. In some patients with rheumatoid arthritis, there is a dis-crepancy between the processes of bone resorption and bone formation, which is the cause of secondary metabolic osteopathy. A complication of rheumatoid arthritis with a change in bone quality is osteoporosis. Reduced bone density and an increased risk of fractures in osteoporosis determine the adverse course and significantly worsen the prognosis of the disease. IHD in combination with rheumatoid arthritis ag-gravates risk factors, leading to a decrease in bone density and an increased risk of fractures in osteoporosis, which determines the unfavorable course and significantly worsens the prognosis of the disease. At the present time, a number of studies the association of an increased risk of osteoporosis with the pres-ence of the following factors in patients with IHD in combination with rheumatoid arthritis has been re-vealed: low bone mineral density, female sex, age 65 years, early menopause, weight less than 57 kg, family history of osteoporosis, previous fractures, prolonged the course of rheumatoid arthritis and irra-tional therapy with glucocorticosteroids. This article presents the results of an analysis of the factors that lead to the development of osteoporosis in patients with ischemic heart disease in combination with rheumatoid arthritis who are inpatient treatment in the rheumatological department. сердечно-сосудистые","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79853402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-30DOI: 10.18413/2075-4728-2018-41-2-228-234
A. V. Avsiankin
{"title":"Restarch warm-characteristics of deformation hard tissue of teeth and restorations photocomposite","authors":"A. V. Avsiankin","doi":"10.18413/2075-4728-2018-41-2-228-234","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-2-228-234","url":null,"abstract":"","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":"307 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76340168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-30DOI: 10.18413/2075-4728-2018-41-2-280-287
L. Rymarova, E. Klyosova, A. Volkova, O. Bushueva, I. Azarova, V. Laskov, A. Polonikov
Polymorphic variants of matrix metalloproteinase genes are an attractive object for testing associations with the risk of ischemic stroke. To date, no studies have been done to assess the contribution of polymorphisms of matrix metalloproteinase genes in the development of ischemic stroke in Russians. The purpose of this study was to analyze the association between polymorphic variants of the genes encoding matrix metalloproteinases type 1 (MMP1 rs1799750) and 2 (MMP2 rs243865) and the risk of ischemic stroke (IS) in Russians from Central Russia. The results of this study, as well as studies performed in oth-er populations clearly demonstrate the crucial role of synergy in the interaction between polymorphic variants of matrix metalloproteinase genes in the predisposition to ischemic stroke, thereby dictating the need for further research in this direction.
{"title":"Analysis of association study between polymorphic variants of genes encoding matrix metalloproteinases types 1 and 2 and the risk of ischemic stroke: pilot study in the central Russia population","authors":"L. Rymarova, E. Klyosova, A. Volkova, O. Bushueva, I. Azarova, V. Laskov, A. Polonikov","doi":"10.18413/2075-4728-2018-41-2-280-287","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-2-280-287","url":null,"abstract":"Polymorphic variants of matrix metalloproteinase genes are an attractive object for testing associations with the risk of ischemic stroke. To date, no studies have been done to assess the contribution of polymorphisms of matrix metalloproteinase genes in the development of ischemic stroke in Russians. The purpose of this study was to analyze the association between polymorphic variants of the genes encoding matrix metalloproteinases type 1 (MMP1 rs1799750) and 2 (MMP2 rs243865) and the risk of ischemic stroke (IS) in Russians from Central Russia. The results of this study, as well as studies performed in oth-er populations clearly demonstrate the crucial role of synergy in the interaction between polymorphic variants of matrix metalloproteinase genes in the predisposition to ischemic stroke, thereby dictating the need for further research in this direction.","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74394479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-30DOI: 10.18413/2075-4728-2018-41-2-305-316
V. Ruzhenkova, V. Ruzhenkov, I. Shkileva, E. V. Shelyakina, Ya.V. Sidyakina, N. M. Naumenko
Applicants who entering medical schools are characterized by a high level of stress and anxiety and in the initial years of study they meet the high level of academic stress, which negatively affects their health. In this regard, the study aimed to verify the prevalence of anxiety and anxiety-phobic disorders among first-year medical students to develop recommendations for prevention. A sample of 166 Russian-speaking first-year students aged 17 to 22 (18.0±0.9) years were examined at the 3-4 months of study using the structured interview, clinical psychopathological and psychometric methods. met. More than a third part of the students of both groups used alcohol, took medications, and communi-cated in a social network for a long time to reduce stress, which creates the risk of addictive behavior. Thus, due to the high level of educational stress accompanied by affective and psychosomatic symptoms, trainings for "Time Management" and "Stress Management" are necessary for first-year medical students (at the beginning of course of study). Comparative characteristics of the level of stress associated with the organization of the educational process (the Mann-Whitney test)
{"title":"Academic stress affects on the appearance of anxiaty and anxiaty-fobic dis-orders in first year medical students","authors":"V. Ruzhenkova, V. Ruzhenkov, I. Shkileva, E. V. Shelyakina, Ya.V. Sidyakina, N. M. Naumenko","doi":"10.18413/2075-4728-2018-41-2-305-316","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-2-305-316","url":null,"abstract":"Applicants who entering medical schools are characterized by a high level of stress and anxiety and in the initial years of study they meet the high level of academic stress, which negatively affects their health. In this regard, the study aimed to verify the prevalence of anxiety and anxiety-phobic disorders among first-year medical students to develop recommendations for prevention. A sample of 166 Russian-speaking first-year students aged 17 to 22 (18.0±0.9) years were examined at the 3-4 months of study using the structured interview, clinical psychopathological and psychometric methods. met. More than a third part of the students of both groups used alcohol, took medications, and communi-cated in a social network for a long time to reduce stress, which creates the risk of addictive behavior. Thus, due to the high level of educational stress accompanied by affective and psychosomatic symptoms, trainings for \"Time Management\" and \"Stress Management\" are necessary for first-year medical students (at the beginning of course of study). Comparative characteristics of the level of stress associated with the organization of the educational process (the Mann-Whitney test)","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":"34 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77514686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-30DOI: 10.18413/2075-4728-2018-41-2-245-253
I. Simanov
{"title":"Cytokine levels in postmenopausal women depending on IL-6, TNFSF11 and TNFRSF11B genes polymorphisms","authors":"I. Simanov","doi":"10.18413/2075-4728-2018-41-2-245-253","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-2-245-253","url":null,"abstract":"","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75977585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-30DOI: 10.18413/2075-4728-2018-41-2-220-227
A. A. Kopytov, A. Nikishaeva, L. B. Pashchenko, I. Fedorova, N. М. Kunitsyna, Z. K. Kozyreva
The diseases of the hard tissue of teeth (tooth decay and it’s complications) and the pathology of digestive organs of teenagers are both an actual medical and social problem that needs to be solved. The changes in the body of teenagers caused by the concomitant pathology of diseases of the oral cavity and digestive organs are described in this article. Their main clinical symptoms and interdependence between the pathological processes are also outlined. The immunological processes occurring in the body play a huge role in the etiology and pathogenesis of the diseases of teeth. In its turn tooth decay influences the develop-ment of digestive organs’ disorders because a carious tooth is a source of permanent microbian invasion. Close relationship between this pathological processes determine the need of a comprehensive approach to treatment of the patients. The information outlined in the article underline the expediency of diagnostic system reorganization by including the results of dental examination into the medical card of a child. This lets to optimize the work of both dentists and pediatrician.
{"title":"The study of changes in the body of adolescents with combined pathology of the oral cavity and digestive organs","authors":"A. A. Kopytov, A. Nikishaeva, L. B. Pashchenko, I. Fedorova, N. М. Kunitsyna, Z. K. Kozyreva","doi":"10.18413/2075-4728-2018-41-2-220-227","DOIUrl":"https://doi.org/10.18413/2075-4728-2018-41-2-220-227","url":null,"abstract":"The diseases of the hard tissue of teeth (tooth decay and it’s complications) and the pathology of digestive organs of teenagers are both an actual medical and social problem that needs to be solved. The changes in the body of teenagers caused by the concomitant pathology of diseases of the oral cavity and digestive organs are described in this article. Their main clinical symptoms and interdependence between the pathological processes are also outlined. The immunological processes occurring in the body play a huge role in the etiology and pathogenesis of the diseases of teeth. In its turn tooth decay influences the develop-ment of digestive organs’ disorders because a carious tooth is a source of permanent microbian invasion. Close relationship between this pathological processes determine the need of a comprehensive approach to treatment of the patients. The information outlined in the article underline the expediency of diagnostic system reorganization by including the results of dental examination into the medical card of a child. This lets to optimize the work of both dentists and pediatrician.","PeriodicalId":8785,"journal":{"name":"Belgorod State University Scientific bulletin Medicine Pharmacy","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75901174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-30DOI: 10.18413/2075-4728-2018-41-2-317-326
O. A. Kisteneva, E. Berdnikova, V. V. Kistenev
The article analyzes the history of the formation and development of the regional state budgetary health care institution "Tomarovskaya District Hospital named after I.S. Sal'tevskij" Belgorod region in the late XIX century – the beginning of the XXI century. The study is carried out through the study of regional archival materials. It is noted that the heads of the hospital played a special role in the development of the medical institution. From the organizational and professional qualities of the chief doctors depended the pace of construction of new buildings, the attraction of highly qualified specialists to the region, coordination of the activities of medical services. The scientific data is entered from the family archive and personal diaries of I.S. Sal'tevskij, who was the chief physician of the hospital from 1962 to 1993, laid the foundations of the hospital town of Tomarovka Belgorod region and made a huge contribution to the development of the hospital. Ключевые слова: здравоохранение, Белгородская область, история развития лечебного учреждения, Сальтевский И.С., главный врач, Томаровская больница им. И.С. Сальтевского, исследование.
本文分析了区域性国家预算卫生保健机构“托马罗夫斯卡亚区医院”的形成和发展历史，该医院以iss Sal'tevskij命名，于19世纪末至21世纪初在别尔哥罗德地区。本研究是通过对区域档案资料的研究来进行的。报告指出，医院院长在医疗机构的发展中发挥了特殊作用。主要医生的组织和专业素质取决于新建筑的建设速度、吸引高素质专家到该地区、医疗服务活动的协调。科学数据来自I.S. Sal'tevskij的家庭档案和个人日记，他于1962年至1993年担任医院的主任医生，奠定了托马罗夫卡别尔哥罗德地区医院城的基础，并为医院的发展作出了巨大贡献。Ключевыеслова:здравоохранение,Белгородскаяобласть,историяразвитиялечебногоучреждения,СальтевскийИС。， главный врач， Томаровская больница им。ИС。Сальтевского,исследование。
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