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Mineralogical composition of the Santonian deposits of the North Konimekh deposit in Uzbekistan 乌兹别克斯坦Konimekh北部矿床三东期矿床的矿物组成
Pub Date : 2023-01-01 DOI: 10.1051/bioconf/20236509005
Isomiddin Togaev, Doston Buriboyev, Shoxrux Toshtemirov, Baxtinur Abdujabborov
The article presents information about the results of studying the material composition, mineralogy and geochemistry of deposits formed in the Upper Cretaceous (K2) Santon strata of the North Konimekh uranium deposit located in the Kyzylkum region. Prospecting, appraisal and exploration at the North Konimekh uranium mine is an urgent problem, as it is in the focus of attention of many researchers. This article provides extensive information on underground alkalization, one of the methods for extracting uranium raw materials. Currently, it is emphasized that this method is convenient, has high financial efficiency in the extraction of uranium raw materials, and is also one of the cheapest and most effective methods.
本文介绍了位于Kyzylkum地区的北Konimekh铀矿床上白垩统(K2) Santon地层中形成的矿床的物质组成、矿物学和地球化学研究结果。北科尼梅赫铀矿的找矿、评价和勘探是一个迫切需要解决的问题,是许多研究者关注的焦点。本文详细介绍了地下碱化开采铀原料的方法之一。目前强调该方法提取铀原料方便,经济效益高,也是最便宜、最有效的方法之一。
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引用次数: 0
Effect of Exogenous Spermine on Biofilm Formation in Mycobacteria by Stimulating the Synthesis of Glycopeptidolipids 外源精胺通过刺激糖肽脂合成对分枝杆菌生物膜形成的影响
Pub Date : 2023-01-01 DOI: 10.1051/bioconf/20235702002
I. Tsyganov, А.G. Tkachenko
Biofilm formation is of great interest by its ability to increase bacterial tolerance to antibiotics that represent a serious problem for modern medicine. Among mycobacteria, which are also capable of forming biofilms, there are pathogens of socially dangerous infections, including tuberculosis. Basing on these data, the strains of Mycolicibacterium smegmatis mc2 155 were chosen as the objects of this study, including the parent strain without deletions and its mutants with one (ΔrelMsm) and double (ΔrelMsmΔrelZ) chromosomal deletions of the genes responsible for the synthesis of alarmone synthetase enzymes. Biofilms of mutant strains exhibited defects in biofilm formation. We have shown that the integrity, hydrophobicity, and the level of biomass of surface mycobacterial biofilms are dependent on the amount of glycopeptidolipids (GPL) in cells. The level of GPL depends on the activity of alarmone synthetases. The biogenic polyamine spermine is able to enhance the production of GPLs, restoring the integrity of biofilms of mutant strains. It is possible that this effect of spermine is caused by the influence on the activity of mycobacterial alarmone synthetases, which makes promising the further studying the molecular mechanisms of its action.
生物膜的形成是非常有趣的,因为它能够增加细菌对抗生素的耐受性,这是现代医学的一个严重问题。在分枝杆菌中,也能够形成生物膜,其中有社会危险感染的病原体,包括结核病。在此基础上,选择耻垢分枝杆菌mc2155菌株作为研究对象,包括无缺失的亲本菌株及其1个(ΔrelMsm)和2个(ΔrelMsmΔrelZ)染色体缺失负责合成alarmone合成酶基因的突变体。突变菌株的生物膜在生物膜形成方面存在缺陷。我们已经证明,分枝杆菌表面生物膜的完整性、疏水性和生物量水平取决于细胞中糖肽类磷脂(GPL)的含量。GPL的水平取决于alarmone合成酶的活性。生物多胺精胺能够增强gpl的产生,恢复突变菌株生物膜的完整性。精胺的这种作用可能是通过影响分枝杆菌的警铃酮合成酶活性引起的,这为进一步研究其作用的分子机制提供了前景。
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引用次数: 0
Physicochemical, Antibacterial, and Cytotoxic Properties of Composite Materials Based on Biodegradable Poly (Lactic-Co-Glycolic Acid) Functionalized with Zno Nanoparticles 纳米氧化锌功能化可生物降解聚乳酸-羟基乙酸复合材料的理化、抗菌和细胞毒性研究
Pub Date : 2023-01-01 DOI: 10.1051/bioconf/20235702005
D. Burmistrov, D. Serov, D. Grigorieva, A. Simakin
One of the tasks of modern nanotechnology is the creation of new materials with a wide range of applications and good antibacterial activity. In this work, we developed a new composite material based on poly(lactic-co-glycolic acid) and zinc oxide nanoparticles. The resulting material had a smooth surface without microdefects. The polymer matrix did not affect the generation of reactive oxygen species, 8-oxoguanine, and long-lived protein forms. The addition of ZnO-NPs enhanced the generation of these compounds. The addition of ZnO-NPs to the polymer at a concentration of 0.001-0.1 wt% made it possible to achieve a significant bacteriostatic effect, while not affecting the growth, division, and viability of eukaryotic cells. The resulting composite material is of great interest for biomedical use and the food industry due to controlled biodegradability and antibacterial activity.
现代纳米技术的任务之一是创造具有广泛应用和良好抗菌活性的新材料。在这项工作中,我们开发了一种新的基于聚乳酸-羟基乙酸和氧化锌纳米颗粒的复合材料。所得材料表面光滑,无微缺陷。聚合物基质不影响活性氧、8-氧鸟嘌呤和长寿命蛋白质形式的产生。ZnO-NPs的加入促进了这些化合物的生成。在聚合物中添加浓度为0.001-0.1 wt%的ZnO-NPs,可以达到显著的抑菌效果,同时不影响真核细胞的生长、分裂和活力。由此产生的复合材料由于具有可控的生物降解性和抗菌活性,在生物医学和食品工业中具有很大的应用价值。
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引用次数: 0
Bioecology of russet mites in tomatoes and their control 番茄褐螨的生物生态学及其防治
Pub Date : 2023-01-01 DOI: 10.1051/bioconf/20236501019
Abdusalim Yusupov, Dilnoza Nuralieva, Asamiddin Kholliev
Tomato russet mite develops freely and quickly mainly on tomatoes and potatoes. The next places are occupied by black and red nightshades and eggplant. The mite can press both the upper and lower sides of the plant leaves. First, the lower leaves and branches of the plant begin to be damaged. It gradually spreads upwards. The affected branch becomes smooth with a brown color, yellow spots appear on the leaves, and the general color begins to turn brown. Infected flowers and small fruit buds and leaves dry up and fall off, large fruits have a web-like pattern and crack. In this article, the species composition, distribution, damage to plants and bioecology of the pest are covered in this article. The development characteristics of the russet mite by plant are presented, in which tomato, potato, and eggplant plants are the most common tomato russet mite in the analysis based on the table. In addition, the results of the research on the effect of the tomato russet mite on productivity in different growth periods are highlighted.
番茄赤霉病螨主要在番茄和马铃薯上繁殖迅速、繁殖自由。接下来的位置是黑色和红色的茄和茄子。螨虫可以按压植物叶片的上下两侧。首先,植物下部的叶子和树枝开始受损。它逐渐向上扩散。受影响的树枝变得光滑,呈棕色,叶子上出现黄色斑点,整体颜色开始变成棕色。受感染的小花和小果实芽叶干枯脱落,大果实有网状花纹和裂纹。本文介绍了该害虫的种类组成、分布、对植物的危害及生物生态学。介绍了植物赤铁矿螨的发育特点,根据表格分析,番茄、马铃薯和茄子是番茄赤铁矿螨最常见的植物。重点介绍了不同生育期番茄赤霉病螨对产量影响的研究结果。
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引用次数: 0
Agronomic assessment of the herbicides application on winter wheat crops 冬小麦除草剂施用的农艺评价
Pub Date : 2023-01-01 DOI: 10.1051/bioconf/20236604004
O. Savoskina, S. Chebanenko, I. Zavertkin, A. Shitikova, S. Zapivalov
In modern conditions of agricultural production, it is important to obtain a high yield of good quality, which may be limited by a high degree of contamination of crops. At the same time, it is necessary to search for new approaches to the weed control problem, which involves solving a number of issues: determining and analyzing the floral composition of weeds with constant monitoring of contamination to make forecasts and make operational decisions. This work is devoted to the study of these issues. It reveals the features of winter wheat agrophytocenosis formation with the analysis of weed species composition, and shows the effectiveness of the use of herbicides recommended on the basis of mapping. The biological efficiency of the spray mixture of herbicides Verdict + Dinat was 84.1% (by the number of weeds) and 94.9% (by air-dry weight). The agronomic effectiveness of herbicides was expressed in obtaining an increase in yield of 2.67 t/ha, and the profitability level was above the threshold of economic feasibility of the weed management and amounted to 141.8%.
在现代农业生产条件下,获得高质量的高产是很重要的,但这可能受到作物污染程度高的限制。与此同时,有必要寻找新的方法来解决杂草控制问题,这涉及到解决一些问题:确定和分析杂草的花卉组成,不断监测污染,做出预测和操作决策。本书致力于研究这些问题。通过对杂草种类组成的分析,揭示了冬小麦农草病形成的特征,并在作图的基础上显示了推荐除草剂的使用效果。判决+迪纳特混合除草剂的生物效率(以杂草数量计)为84.1%,以空气干重计为94.9%。除草剂的农艺效益表现为增产2.67 t/ha,盈利水平高于杂草管理经济可行性阈值,达141.8%。
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引用次数: 0
Systematic Composition and Analysis of the Biomorph of Medicinal Plants in the Flora of the Chechen Republic 车臣共和国植物区系药用植物的系统组成及生物形态分析
Pub Date : 2023-01-01 DOI: 10.1051/bioconf/20236306005
Z. Iriskhanova, H. R. Hanaeva, Sh. M. Bakasheva
It was extremely difficult for the deported peoples to adapt to new natural conditions, and to a new ethnic environment, and to a new humiliating situation. K.D. Ushinsky wrote that the influence of natural conditions on people is so powerful that the destruction of these conditions (and in this case separation) torments a person with painful homesickness. A number of government regulations established a cruel special regime. Settlers scattered in small groups from Kyrgyzstan to Kazakhstan did not have the opportunity to keep in touch with each other. In order to survive physically and morally, the settlers had to prove their innocence every minute of their existence. Adaptation in new geographic and climatic conditions, different from historical ones, had a dominating and depressing effect on the moral and psychological state of people.
对于被驱逐的人民来说,适应新的自然条件、新的民族环境和新的屈辱处境是极其困难的。K.D. Ushinsky写道,自然条件对人的影响是如此强大,以至于这些条件的破坏(在这种情况下是分离)使人痛苦地想家。许多政府条例建立了一个残酷的特殊制度。从吉尔吉斯斯坦到哈萨克斯坦,分散在小群体中的移民没有机会彼此保持联系。为了身体和精神上的生存,移民们必须在他们生存的每一分钟证明自己的清白。不同于历史上的地理和气候条件下的适应,对人们的道德和心理状态产生了支配和压抑的作用。
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引用次数: 0
Stability and Bifurcation of Tumor Immune Model with Time Delay 具有时滞的肿瘤免疫模型的稳定性和分岔
Pub Date : 2023-01-01 DOI: 10.1051/bioconf/20235902017
Li Yangjuan, Xiao Zhengying, Lin Jinzhong
In this paper, we investigate the effect of time delay on the stability of the tumor immune system using theoretical calculations and numerical simulations. Since it takes a certain time for immune cells to recognize tumor cells to make an appropriate response, a model of tumor-immune system interaction with time delay is established by considering time delay in this process. The four equilibrium points are solved by simplifying the model using Taylor expansion with a small time delay. Then the stability of each equilibrium point of the system under a small time delay is determined by calculating the characteristic roots of each equilibrium point with numerical simulation software. The results show that the system has a bistability phenomenon. The saddle point and stable node are not affected by the delay, while only the stability of the stable foci changes with the time delay with Hopf bifurcation. This study can help determine the optimal time for tumor treatment and provide a reference for analyzing tumor status and treatment.
本文采用理论计算和数值模拟的方法研究了时间延迟对肿瘤免疫系统稳定性的影响。由于免疫细胞对肿瘤细胞的识别需要一定的时间才能做出适当的反应,因此考虑到这一过程中的时间延迟,建立了肿瘤-免疫系统相互作用的时滞模型。利用Taylor展开式对模型进行了简化,求解了四个平衡点。然后利用数值模拟软件计算各平衡点的特征根,确定系统在小时延下各平衡点的稳定性。结果表明,该系统具有双稳态现象。鞍点和稳定节点不受时延的影响,只有稳定焦点的稳定性随时延变化而变化,存在Hopf分岔。本研究有助于确定肿瘤的最佳治疗时间,为分析肿瘤状态及治疗提供参考。
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引用次数: 0
Stimulus-responsive tumor supramolecular nanotherapeutic system based on indocyanine green 基于吲哚菁绿的刺激反应性肿瘤超分子纳米治疗系统
Pub Date : 2023-01-01 DOI: 10.1051/bioconf/20236101003
Wenbi Feng, Yuhan Wei, Xianfeng Zhou
Indocyanine green (ICG), a clinical near-infrared fluorescent probe, has the potential to be used as an integrated diagnostic and therapeutic agent for tumors. In this study, ICG-COOH-TK was obtained by connecting ICG molecules through stimulus-responsive thioketone (TK) bond, which can self-assemble into nanoparticles in water. Under 808 nm near-infrared light irradiation, the molecule exhibited excellent photothermal conversion efficiency, as well as better photostability and in vivo circulation stability than free ICG. The nanoparticle can respond to reactive oxygen species (ROS) overexpression in the tumor microenvironment and release ICG upon disassembly, resulting in significantly enhanced fluorescence emission at the tumor. In vitro cell experiments demonstrated excellent biocompatibility and photothermal killing effect on cancer cells, indicating that this molecule can serve as a diagnostic and therapeutic agent for fluorescence-guided tumor photothermal therapy.
吲哚菁绿(ICG)是一种临床近红外荧光探针,具有作为肿瘤综合诊断和治疗药物的潜力。本研究通过刺激响应型硫酮(TK)键连接ICG分子获得ICG- cooh -TK, ICG- cooh -TK可在水中自组装成纳米颗粒。在808 nm近红外光照射下,该分子表现出优异的光热转化效率,并具有比游离ICG更好的光稳定性和体内循环稳定性。该纳米颗粒可以响应肿瘤微环境中活性氧(ROS)的过度表达,并在拆卸后释放ICG,从而显著增强肿瘤处的荧光发射。体外细胞实验表明,该分子具有良好的生物相容性和对癌细胞的光热杀伤作用,可作为荧光引导肿瘤光热治疗的诊断和治疗剂。
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引用次数: 0
Tactics of surgical treatment in necrotising enterocolitis stage II-B in newborn 新生儿坏死性小肠结肠炎II-B期的外科治疗策略
Pub Date : 2023-01-01 DOI: 10.1051/bioconf/20236505005
A. Vakhidov, D. Mamarasulova, Akmal Khaitov
An analysis was made of the results of surgical treatment of 18 newborns with a diagnosis of stage II-B NEC, admitted in the period from 2018 to 2022. The aim of the work: to analyze the results of surgical treatment for stage II-B necrotizing enterocolitis in newborns using modern technologies. A total of 18 diagnostic laparoscopies (DL) were performed, of which 4 cases were converted - laparotomy. In 14 patients cases, DL was completed by therapeutic laparoscopy using minilaparotomy with video-assessment, including 8 patients, resection of the necrotic portion of the intestine was performed with end-to-end anastomosis. In 6 cases, an intestinal stoma was applied through a minilaparotomy.In comparison, after laparoscopic operations with video assessment, mortality was observed of cases 1 patient out of 14, after traditional surgical interventions, mortality was in 25% of cases 1 patient out of 4. Based on the results of DL at the surgical stage of NEC, it is possible to build further tactics of radical surgical treatment, the possibility of transforming it into a therapeutic one minimizes intraoperative trauma, which positively affects the postoperative survival of patients.
分析2018年至2022年收治的18例II-B期NEC新生儿的手术治疗结果。目的:分析现代技术在新生儿II-B期坏死性小肠结肠炎手术治疗中的应用效果。共行诊断性腹腔镜检查18例,其中中转开腹4例。在14例患者中,治疗性腹腔镜下采用小切口视频评估完成DL,其中8例患者采用端对端吻合术切除小肠坏死部分。6例采用小切口肠造口术。相比之下,采用视频评估的腹腔镜手术后死亡率为1 / 14,而采用传统手术干预后死亡率为25%,为1 / 4。基于手术阶段DL的结果,可以建立进一步的根治性手术治疗策略,将其转化为治疗性治疗的可能性最小化术中创伤,这对患者的术后生存有积极的影响。
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引用次数: 0
Role of foliar biostimulants (of plant origin) on grapevine adaptation to climate change 叶面生物刺激素(植物源)在葡萄适应气候变化中的作用
Pub Date : 2023-01-01 DOI: 10.1051/bioconf/20235601002
L. Bavaresco, Ginevra Canavera, M. G. Parisi, L. Lucini
Heat waves and drought stress are typical aspects of current climate change, significantly affecting the grapevine physiology in many world growing areas. Biostimulants can play an important role in reducing the negative effects of climate change; that’s why this experiment was set up in order to test two new foliar biostimulants (protein hydrolysates of plant origin). The field experiment was carried out in 2017 and 2018 in Oltrepo pavese area (Lombardia region, northwest Italy, 270 m asl), on a six-year-old vineyard of V. vinifera L. cv. Merlot clone 181 grafted on Gravesac, Guyot trellis, 4,000 vines/ha and not irrigated. Two new protein hydrolysates of plant origin were sprayed twice, just after fruit set and 15 days later, by using 2.5 L/ha. Leaf proteomics and metabolomics were studied in 2017, while productive and qualitative data were recorded in both years at harvest (September 1st, 2017 and August 28th 2018). The most significant findings were: (a) the treatments slowed down the grape ripening, by stimulating vegetative activity and reducing sugar accumulation; (b) less heat and drought stress symptoms were observed in the canopies of treated vines, as compared to the control ones.
热浪和干旱胁迫是当前气候变化的典型方面,显著影响着世界上许多葡萄种植区的葡萄生理。生物刺激剂可以在减少气候变化的负面影响方面发挥重要作用;这就是为什么这个实验是为了测试两种新的叶面生物刺激剂(植物来源的蛋白质水解物)而建立的。该田间试验于2017年和2018年在Oltrepo pavese地区(意大利西北部伦巴第大区,海拔270米)的一个6年葡萄园上进行。梅洛181克隆嫁接于格雷夫萨克、盖尤特棚架上,4000株/公顷,不灌溉。两种新的植物源蛋白水解物分别在坐果后和15天后喷施两次,喷施量为2.5 L/ha。2017年进行了叶片蛋白质组学和代谢组学研究,并记录了收获年份(2017年9月1日和2018年8月28日)的生产和定性数据。最显著的发现是:(a)通过刺激营养活动和减少糖积累,处理减缓了葡萄的成熟;(b)与对照相比,处理过的葡萄藤树冠上观察到的高温和干旱胁迫症状较少。
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