Pub Date : 2023-01-01DOI: 10.1051/bioconf/20235603013
E. Lamonaca, A. Seccia, F. Santeramo
New production and trade patterns due to climate change and policy interventions are increasingly affecting the wine sector. This paper investigates how patterns of production and trade in main wine producing regions respond to changes in climate and policy interventions. An approach based on a combination of Ricardian trade and climate models suggests that higher temperatures in the main producing regions of wine benefit both production and trade of wine. A gravity-based analysis shows that the effects of policy interventions on the global trade of wine are heterogeneous and dependent on the specific objective of the intervention.
{"title":"The role of climate and trade policies in the wine sector","authors":"E. Lamonaca, A. Seccia, F. Santeramo","doi":"10.1051/bioconf/20235603013","DOIUrl":"https://doi.org/10.1051/bioconf/20235603013","url":null,"abstract":"New production and trade patterns due to climate change and policy interventions are increasingly affecting the wine sector. This paper investigates how patterns of production and trade in main wine producing regions respond to changes in climate and policy interventions. An approach based on a combination of Ricardian trade and climate models suggests that higher temperatures in the main producing regions of wine benefit both production and trade of wine. A gravity-based analysis shows that the effects of policy interventions on the global trade of wine are heterogeneous and dependent on the specific objective of the intervention.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90632252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1051/bioconf/20236510003
Z. Ismailova, S. Ashurova, Z. Nasimova, A. Sultanov, O. Shukurova, M. Norqobilov
The article analyzes the scientific ideas of technical thinking and determines its role and importance in the professional activity of the engineer, analyzes the state of the problem of developing students’ technical thinking in psychological and pedagogical theory and practice in higher education, specializes in the development of technical thinking generalization and systematization in accordance with the quality characteristics, as well as the development of technical thinking of engineering students and the development of a mechanism for its implementation.
{"title":"Developing technical thinking of students in the process of preparation for professional activity","authors":"Z. Ismailova, S. Ashurova, Z. Nasimova, A. Sultanov, O. Shukurova, M. Norqobilov","doi":"10.1051/bioconf/20236510003","DOIUrl":"https://doi.org/10.1051/bioconf/20236510003","url":null,"abstract":"The article analyzes the scientific ideas of technical thinking and determines its role and importance in the professional activity of the engineer, analyzes the state of the problem of developing students’ technical thinking in psychological and pedagogical theory and practice in higher education, specializes in the development of technical thinking generalization and systematization in accordance with the quality characteristics, as well as the development of technical thinking of engineering students and the development of a mechanism for its implementation.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90640850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1051/bioconf/20236505020
S. M. Madaminov, N. X. Fattaxov, A. S. Nuriddinov, M. S. Palvanova, I. A. Sakizboev, S. M. Umurzakov
The article presents the experience of surgical treatment of 172 patients with post-burn scar deformities and defects of the lower extremities. Based on the results obtained, practical recommendations on the optimal choice of methods of operations are given.
本文介绍172例下肢烧伤后瘢痕畸形的手术治疗体会。在此基础上，对操作方法的优化选择提出了实用建议。
{"title":"Optimization of surgical treatment of post-burn scar deformities of the lower extremities","authors":"S. M. Madaminov, N. X. Fattaxov, A. S. Nuriddinov, M. S. Palvanova, I. A. Sakizboev, S. M. Umurzakov","doi":"10.1051/bioconf/20236505020","DOIUrl":"https://doi.org/10.1051/bioconf/20236505020","url":null,"abstract":"The article presents the experience of surgical treatment of 172 patients with post-burn scar deformities and defects of the lower extremities. Based on the results obtained, practical recommendations on the optimal choice of methods of operations are given.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86979367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1051/bioconf/20236611001
Alexandra Kamova, Tatiana Stepanova, Anna Orlova, Galina Stepanova, Marina Rumyantseva
Two-year studies of variegated alfalfa (Medicago varia Mart.) of the following varieties and hybrids were carried out: Pastbischnaya 88, Taisia, Agnia VIC, 506 and SGP, as well as observations of their reaction to inoculation. Strains of nodule bacteria Sinorhizobium meliloti were used as inoculants: SHM1-105, 415, A-1, A-5, and a control variant without inoculation. As a result of research, it was revealed that the minimum length of stems in 2021 was fixed in the Pastbischnaya 88 + 415 variant, and amounted to 12.5 cm, in 2022 — Taisia with A1 and SHM1-105, 8.8 cm each. The maximum length of stems in 2021 was marked by a hybrid 506 in a combination of A1 and SHM1-105 strains, the indicator was 40.4 and 40.3, respectively, in 2022 — Agnia VIC + A5, 28 cm. In 2021, the Pastbischnaya 88 variety with the strain SHM1-105 turned out to be the most competitive, its share prevailed over the unseeded admixture, and reached 54.8%, in 2022 variant Agnia VIC + 415 was distinguished with this indicator, with a mass fraction of 65.45%. The positive effect of inoculation was revealed, the best symbiotic varietal microbial systems were determined. The strain of nodule bacteria 415 is marked by a complex effect on all varieties of variegated alfalfa. According to the yield of dry weight (3.3 t/ha on average), the Taisia variety and the SGP hybrid were distinguished.
{"title":"Methods of increasing the productivity of various varieties and hybrids of variegated alfalfa in the conditions of arable farming biologization","authors":"Alexandra Kamova, Tatiana Stepanova, Anna Orlova, Galina Stepanova, Marina Rumyantseva","doi":"10.1051/bioconf/20236611001","DOIUrl":"https://doi.org/10.1051/bioconf/20236611001","url":null,"abstract":"Two-year studies of variegated alfalfa (Medicago varia Mart.) of the following varieties and hybrids were carried out: Pastbischnaya 88, Taisia, Agnia VIC, 506 and SGP, as well as observations of their reaction to inoculation. Strains of nodule bacteria Sinorhizobium meliloti were used as inoculants: SHM1-105, 415, A-1, A-5, and a control variant without inoculation. As a result of research, it was revealed that the minimum length of stems in 2021 was fixed in the Pastbischnaya 88 + 415 variant, and amounted to 12.5 cm, in 2022 — Taisia with A1 and SHM1-105, 8.8 cm each. The maximum length of stems in 2021 was marked by a hybrid 506 in a combination of A1 and SHM1-105 strains, the indicator was 40.4 and 40.3, respectively, in 2022 — Agnia VIC + A5, 28 cm. In 2021, the Pastbischnaya 88 variety with the strain SHM1-105 turned out to be the most competitive, its share prevailed over the unseeded admixture, and reached 54.8%, in 2022 variant Agnia VIC + 415 was distinguished with this indicator, with a mass fraction of 65.45%. The positive effect of inoculation was revealed, the best symbiotic varietal microbial systems were determined. The strain of nodule bacteria 415 is marked by a complex effect on all varieties of variegated alfalfa. According to the yield of dry weight (3.3 t/ha on average), the Taisia variety and the SGP hybrid were distinguished.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77326336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1051/bioconf/20236305013
Saralinova Dzhamilya, V. Fursov, D. Dokhkilgova
At the present stage, one of the scientific problems of research is the study of processes and factors influencing sustainable development. The increasing relevance of methods for achieving sustainable development of the world economy is due to several factors. The fuel and energy complex is not only the backbone of the Russian economy, but also one of the most important elements in ensuring (taking into account climatic conditions) the country’s energy security. The geopolitical factor today forms the energy reality, and this trend implies the growing importance of developing an optimal mechanism for managing all processes in this area. Particular attention in public administration should be given to updating the priority tasks of the state energy policy and energy strategies of the Russian Federation, taking into account the goals of sustainable development. The strategic task today is to protect Russia’s interests in the dynamic system of regulation of world energy markets.
{"title":"Tasks of State Management of the Fuel and Energy Complex for Sustainable Development","authors":"Saralinova Dzhamilya, V. Fursov, D. Dokhkilgova","doi":"10.1051/bioconf/20236305013","DOIUrl":"https://doi.org/10.1051/bioconf/20236305013","url":null,"abstract":"At the present stage, one of the scientific problems of research is the study of processes and factors influencing sustainable development. The increasing relevance of methods for achieving sustainable development of the world economy is due to several factors. The fuel and energy complex is not only the backbone of the Russian economy, but also one of the most important elements in ensuring (taking into account climatic conditions) the country’s energy security. The geopolitical factor today forms the energy reality, and this trend implies the growing importance of developing an optimal mechanism for managing all processes in this area. Particular attention in public administration should be given to updating the priority tasks of the state energy policy and energy strategies of the Russian Federation, taking into account the goals of sustainable development. The strategic task today is to protect Russia’s interests in the dynamic system of regulation of world energy markets.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90672389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1051/bioconf/20235902010
Chang Qi, Yang Wu
In the aftermath of the new crown epidemic, people’s lives have been turned upside down and stress levels have increased, resulting in negative psychological and mental health outcomes. Anxiety, depression, insomnia, and other psychological symptoms ensued. And if appropriate measures are not taken in a timely manner, the “psychological crisis pandemic” will erode people more than COVID-19. To date, many experts have proposed interventions centred on maintaining the mental health of the population. Considering some special populations and the specificity of the epidemic period, researchers have given a variety of references, encompassing traditional psychological treatment methods and emerging online therapies. This paper reviews and summarizes the psychological problems that emerged in the population during the COVID-19 pandemic, and proposes appropriate interventions for different populations, providing feasible solutions for maintaining the mental health of the population, which will help people have a clearer understanding of mental health and prevent mental illness in time.
{"title":"Mental health outcomes and psychological interventions during the COVID-19 pandemic","authors":"Chang Qi, Yang Wu","doi":"10.1051/bioconf/20235902010","DOIUrl":"https://doi.org/10.1051/bioconf/20235902010","url":null,"abstract":"In the aftermath of the new crown epidemic, people’s lives have been turned upside down and stress levels have increased, resulting in negative psychological and mental health outcomes. Anxiety, depression, insomnia, and other psychological symptoms ensued. And if appropriate measures are not taken in a timely manner, the “psychological crisis pandemic” will erode people more than COVID-19. To date, many experts have proposed interventions centred on maintaining the mental health of the population. Considering some special populations and the specificity of the epidemic period, researchers have given a variety of references, encompassing traditional psychological treatment methods and emerging online therapies. This paper reviews and summarizes the psychological problems that emerged in the population during the COVID-19 pandemic, and proposes appropriate interventions for different populations, providing feasible solutions for maintaining the mental health of the population, which will help people have a clearer understanding of mental health and prevent mental illness in time.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90771405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1051/bioconf/20236503006
Mukhammadali Saidov, I. Ochilov
This article analyzes the theoretical aspects of clusters in the innovative economy and their management, including the increase in economic efficiency of agro-clusters as a result of the organization of the agricultural sector on the basis of “production - service - production - storage - supply - processing - sales” development of cluster services, increase in production and diversification of exported finished products as a result of improvements, the authors have developed a unique, new definition of the term “cluster”. From a methodological point of view, the “face” of a cluster, its specialization and name are formed by the cluster core companies, and this is of fundamental importance. Companies that belong to one cluster core cannot access the core of another cluster, but can participate in another cluster at the second or third level of the cluster structure. As the companies in the cluster core produce the same type of products, competition between them will continue. A key feature of the cluster core is the competition between the companies that make it up, i.e. there is both competition and collaboration in the cluster core. As a result authors, proposals were made to improve the efficiency of clusters in Uzbekistan.
{"title":"Theoretical analysis of agricultural clusters in innovative economy","authors":"Mukhammadali Saidov, I. Ochilov","doi":"10.1051/bioconf/20236503006","DOIUrl":"https://doi.org/10.1051/bioconf/20236503006","url":null,"abstract":"This article analyzes the theoretical aspects of clusters in the innovative economy and their management, including the increase in economic efficiency of agro-clusters as a result of the organization of the agricultural sector on the basis of “production - service - production - storage - supply - processing - sales” development of cluster services, increase in production and diversification of exported finished products as a result of improvements, the authors have developed a unique, new definition of the term “cluster”. From a methodological point of view, the “face” of a cluster, its specialization and name are formed by the cluster core companies, and this is of fundamental importance. Companies that belong to one cluster core cannot access the core of another cluster, but can participate in another cluster at the second or third level of the cluster structure. As the companies in the cluster core produce the same type of products, competition between them will continue. A key feature of the cluster core is the competition between the companies that make it up, i.e. there is both competition and collaboration in the cluster core. As a result authors, proposals were made to improve the efficiency of clusters in Uzbekistan.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89983569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1051/bioconf/20236306015
R. Ilyasov, A. Chernyavskaya, N. Trots
At present, the ideas of economic, social and environmental balance of development, harmonization of nature and society are no longer new, however, the transformation of the economy based on “green” standards, taking into account rational environmental management and eco-efficiency, remains very relevant in modern conditions. The problem of environmental protection and rational nature management is complex, interdisciplinary and multifaceted. This nature of the problem is determined, first of all, by the complexity of the structure of the managed object. The most important components of the ecological-socio-economic system are nature, man, society and production. All these elements are closely interconnected. Thus, human well-being depends on the socio-economic level of development, the level of manufacturability of production and the state of the natural environment. The development of production depends on the number of workers, the level of their education and training, the state of health and the interest of people in the development of production. At the same time, production depends on the scale and intensity of the use of natural resources. In turn, the state of ecological systems to a decisive extent depends on the scale of production and the nature of production technologies, the results of their impact on nature.
{"title":"“Green” Standards as a Tool for Preserving the Environment","authors":"R. Ilyasov, A. Chernyavskaya, N. Trots","doi":"10.1051/bioconf/20236306015","DOIUrl":"https://doi.org/10.1051/bioconf/20236306015","url":null,"abstract":"At present, the ideas of economic, social and environmental balance of development, harmonization of nature and society are no longer new, however, the transformation of the economy based on “green” standards, taking into account rational environmental management and eco-efficiency, remains very relevant in modern conditions. The problem of environmental protection and rational nature management is complex, interdisciplinary and multifaceted. This nature of the problem is determined, first of all, by the complexity of the structure of the managed object. The most important components of the ecological-socio-economic system are nature, man, society and production. All these elements are closely interconnected. Thus, human well-being depends on the socio-economic level of development, the level of manufacturability of production and the state of the natural environment. The development of production depends on the number of workers, the level of their education and training, the state of health and the interest of people in the development of production. At the same time, production depends on the scale and intensity of the use of natural resources. In turn, the state of ecological systems to a decisive extent depends on the scale of production and the nature of production technologies, the results of their impact on nature.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89530446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1051/bioconf/20235602012
C. Tampaktsi, A. Gancel, J. Escudier, A. Samson, H. Ojeda, L. Pic, J. Rousseau, P. Gauthier, D. Viguier, M. Furet, Pierre-Louis Teissèdre
The hybrids are new varieties that are resistant to the cryptogamic diseases of vines, and they may be a good solution to the reduction of pesticide use. However, these new varieties have appeared recently and only few studies have been conducted to check the quality of the wine that they produce. In this study, wines originated from hybrids were chemically characterized (polyphenols, tannins, anthocyanins, and color analysis). Results show that their oenological parameters were close to those of the Vitis vinifera wines. The wines made from Vinifera (100%), with Vidoc, and all the resistant Bouquets studied are malvidin-3 glucoside dominant, and all the others hybrids varieties are cyanidin dominant. Furthermore, the hybrid wines had a higher concentration in condensed tannins and a lower one in molecular tannins compared with the Vitis vinifera wines, except for the Vidoc wines. As far as the anthocyanin content is concerned, the samples contained anthocyanin diglucosides, with the malvidin-3,5-diglucoside (malvin) the most abundant one. Also, their concentration in molecular anthocyanins were higher than the concentration in normal wines. The Vidoc wines do not contain any malvin. For the other wines, malvin co-eluted with cyanidin-3-O-glucoside and in this case, the cyanidin’s concentration was impressively higher than the Vidoc wines. The current OIV method gives different results for malvidol diglucoside compared to the use of an HPLC chromatography method (HPLC-DAD-QQQ). The current OIV method does not appear reliable in comparison with the HPLC method for detecting malvin. Finally, the hybrid wines had a darker blue/purplish color than the Vitis vinifera wines.
杂交品种是抗葡萄隐孢子病的新品种，是减少农药使用的一个很好的解决方案。然而，这些新品种是最近才出现的，只有很少的研究来检查它们生产的葡萄酒的质量。在这项研究中，对杂交葡萄酒进行了化学表征(多酚、单宁、花青素和颜色分析)。结果表明，其酿酒参数与葡萄品种接近。用Vinifera(100%)、Vidoc和所有抗花酿造的葡萄酒均以malvidin-3葡萄糖苷为主，其他杂交品种均以花青素为主。此外，除了维多克葡萄酒外，杂交葡萄酒的浓缩单宁浓度高于葡萄品种，分子单宁浓度低于葡萄品种。就花青素含量而言，样品中含有花青素二葡糖苷，其中以马柳苷-3,5-二葡糖苷(malvin)含量最多。它们在分子花青素中的含量也高于普通葡萄酒中的含量。维多克葡萄酒不含马尔文酒。对于其他葡萄酒，马尔文与花青素-3- o-葡萄糖苷共洗脱，在这种情况下，花青素的浓度明显高于维多克葡萄酒。与HPLC色谱法(HPLC- dad - qqq)相比，目前的OIV方法对马尔维多二葡糖苷的测定结果有所不同。与高效液相色谱法相比，目前的紫外分光光度法检测马尔文的可靠性不高。最后，混合葡萄酒的颜色比葡萄葡萄酒更深，呈蓝色/紫色。
{"title":"Phenolic potential of new red hybrid grape varieties to produce quality wines and identification by the malvin","authors":"C. Tampaktsi, A. Gancel, J. Escudier, A. Samson, H. Ojeda, L. Pic, J. Rousseau, P. Gauthier, D. Viguier, M. Furet, Pierre-Louis Teissèdre","doi":"10.1051/bioconf/20235602012","DOIUrl":"https://doi.org/10.1051/bioconf/20235602012","url":null,"abstract":"The hybrids are new varieties that are resistant to the cryptogamic diseases of vines, and they may be a good solution to the reduction of pesticide use. However, these new varieties have appeared recently and only few studies have been conducted to check the quality of the wine that they produce. In this study, wines originated from hybrids were chemically characterized (polyphenols, tannins, anthocyanins, and color analysis). Results show that their oenological parameters were close to those of the Vitis vinifera wines. The wines made from Vinifera (100%), with Vidoc, and all the resistant Bouquets studied are malvidin-3 glucoside dominant, and all the others hybrids varieties are cyanidin dominant. Furthermore, the hybrid wines had a higher concentration in condensed tannins and a lower one in molecular tannins compared with the Vitis vinifera wines, except for the Vidoc wines. As far as the anthocyanin content is concerned, the samples contained anthocyanin diglucosides, with the malvidin-3,5-diglucoside (malvin) the most abundant one. Also, their concentration in molecular anthocyanins were higher than the concentration in normal wines. The Vidoc wines do not contain any malvin. For the other wines, malvin co-eluted with cyanidin-3-O-glucoside and in this case, the cyanidin’s concentration was impressively higher than the Vidoc wines. The current OIV method gives different results for malvidol diglucoside compared to the use of an HPLC chromatography method (HPLC-DAD-QQQ). The current OIV method does not appear reliable in comparison with the HPLC method for detecting malvin. Finally, the hybrid wines had a darker blue/purplish color than the Vitis vinifera wines.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89656706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To investigate the therapeutic effects of Coptis chinensis on diabetic nephropathy using systematic pharmacological techniques. The TCMSP database was used to search the main components and related targets of Coptis chinensis; the GeneCards and CTD databases were used to screen the disease targets of diabetic nephropathy, and the intersection of the targets and disease targets was taken and plotted in Venn diagram; the target protein interaction (PPI) network was constructed from STRING database; the DAVID 6.8 online tool was used to GO and KEGG enrichment analyses were performed using DAVID 6.8 online tool to obtain the key signaling pathways of Coptis chinensis acting in diabetic nephropathy. Fourteen effective components of Coptis chinensis and 186 targets were obtained from the TCMSP database, and 3358 diabetic nephropathy targets were obtained from the summary of two databases, GeneCards and CTD. 118 intersecting targets of Coptis chinensis components and diabetic nephropathy diseases were obtained, and the core targets were TP53, MAPK1, AKT1, RELA, TNF, CAV1, RXRA, which may act on MAPK signaling pathway and PI3K-Akt signaling pathway to regulate the inflammatory response and oxidative stress generated by diabetic nephropathy process, thus reducing the disease symptoms. Coptis chinensis can exert its mechanism of action for the treatment of diabetic nephropathy through multiple components with multiple targets and pathways.
{"title":"Study on the Mechanism of Coptis Chinensis in the Treatment of Diabetic Nephropathy Based on Network Pharmacology","authors":"Cheng Yu, Liting Qian, Ying Chen, Jing Guan, Shuang Jiang, Danning Song","doi":"10.1051/bioconf/20236001009","DOIUrl":"https://doi.org/10.1051/bioconf/20236001009","url":null,"abstract":"To investigate the therapeutic effects of Coptis chinensis on diabetic nephropathy using systematic pharmacological techniques. The TCMSP database was used to search the main components and related targets of Coptis chinensis; the GeneCards and CTD databases were used to screen the disease targets of diabetic nephropathy, and the intersection of the targets and disease targets was taken and plotted in Venn diagram; the target protein interaction (PPI) network was constructed from STRING database; the DAVID 6.8 online tool was used to GO and KEGG enrichment analyses were performed using DAVID 6.8 online tool to obtain the key signaling pathways of Coptis chinensis acting in diabetic nephropathy. Fourteen effective components of Coptis chinensis and 186 targets were obtained from the TCMSP database, and 3358 diabetic nephropathy targets were obtained from the summary of two databases, GeneCards and CTD. 118 intersecting targets of Coptis chinensis components and diabetic nephropathy diseases were obtained, and the core targets were TP53, MAPK1, AKT1, RELA, TNF, CAV1, RXRA, which may act on MAPK signaling pathway and PI3K-Akt signaling pathway to regulate the inflammatory response and oxidative stress generated by diabetic nephropathy process, thus reducing the disease symptoms. Coptis chinensis can exert its mechanism of action for the treatment of diabetic nephropathy through multiple components with multiple targets and pathways.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90455074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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