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The value evaluation of Nomogram prediction model based on CTA imaging features for selecting treatment methods for isolated superior mesenteric artery dissection. 基于 CTA 成像特征的 Nomogram 预测模型对孤立性肠系膜上动脉夹层治疗方法选择的价值评估。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-07 DOI: 10.1186/s12880-024-01438-7
Xiaodong Jiang, Dongjian Chen, Qingbin Meng, Xiaokan Liu, Li Liang, Bosheng He, Wenbin Ding

Objective: To evaluate value of Nomogram prediction model based on CTA imaging features for selecting treatment methods for isolated superior mesenteric artery dissection (ISMAD).

Methods: Symptomatic ISMAD patients were randomly divided into a training set and a validation set in a 7:3 ratio. In the training set, relevant risk factors for conservative treatment failure in ISMAD patients were analyzed, and a Nomogram prediction model for treatment outcome of ISMAD was constructed with risk factors. The predictive value of the model was evaluated.

Results: Low true lumen residual ratio (TLRR), long dissection length, and large arterial angle (superior mesenteric artery [SMA]/abdominal aorta [AA]) were identified as independent high-risk factors for conservative treatment failure (P < 0.05). The receiver operating characteristic curve (ROC) results showed that the area under curve (AUC) of Nomogram prediction model was 0.826 (95% CI: 0.740-0.912), indicating good discrimination. The Hosmer-Lemeshow goodness-of-fit test showed good consistency between the predicted curve and the ideal curve of the Nomogram prediction model. The decision curve analysis (DCA) analysis results showed that when probability threshold for the occurrence of conservative treatment failure predicted was 0.05-0.98, patients could obtain more net benefits. Similar results were obtained for the predictive value in the validation set.

Conclusion: Low TLRR, long dissection length, and large arterial angle (SMA/AA) are independent high-risk factors for conservative treatment failure in ISMAD. The Nomogram model constructed with independent high-risk factors has good clinical effectiveness in predicting the failure.

目的评估基于 CTA 成像特征的 Nomogram 预测模型在选择孤立性肠系膜上动脉夹层(ISMAD)治疗方法方面的价值:按 7:3 的比例将有症状的 ISMAD 患者随机分为训练集和验证集。在训练集中,分析了 ISMAD 患者保守治疗失败的相关风险因素,并结合风险因素构建了 ISMAD 治疗结果的 Nomogram 预测模型。对模型的预测价值进行了评估:结果:低真腔残留率(TLRR)、长夹层长度和大动脉角(肠系膜上动脉 [SMA] / 腹主动脉 [AA])被认为是保守治疗失败的独立高危因素(P 结论:低真腔残留率、长夹层长度和大动脉角是导致保守治疗失败的独立高危因素:TLRR低、夹层长度长和动脉角度大(SMA/AA)是导致ISMAD保守治疗失败的独立高危因素。利用独立高危因素构建的 Nomogram 模型在预测治疗失败方面具有良好的临床效果。
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引用次数: 0
Clinic, CT radiomics, and deep learning combined model for the prediction of invasive pulmonary aspergillosis. 预测侵袭性肺曲霉菌病的临床、CT 放射组学和深度学习组合模型。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-07 DOI: 10.1186/s12880-024-01442-x
Kaixiang Zhang, Guoxin Zhao, Yinghui Liu, Yongbin Huang, Jie Long, Ning Li, Huangze Yan, Xiuzhu Zhang, Jingzhi Ma, Yuming Zhang

Background: Invasive pulmonary aspergillosis (IPA) is a serious fungal infection. However, current diagnostic methods have limitations. The purpose of this study was to use artificial intelligence to achieve a more accurate diagnosis of IPA.

Methods: Totally 263 patients (148 cases of IPA, 115 cases of non-IPA) were retrospectively enrolled from a single institution and randomly divided into training and test sets at a ratio of 7:3. Clinic-radiological independent risk factors for IPA were screened using univariate analysis and multivariate logistic regression analysis, after which a clinic-radiological model was constructed. The optimal radiomics features were extracted and screened based on CT images to construct the radiomics label score (Rad-score) and radiomics model. The optimal DL features were extracted and screened using four pre-trained convolutional neural networks, respectively, followed by the construction of the DL label score (DL-score) and DL model. Then, the radiomics-DL model was constructed. Finally, the combined model was constructed based on clinic-radiological independent risk factors, the Rad-score, and the DL-score. LR was adopted as the classifier. Receiver operating characteristic (ROC) curves were drawn, and the areas under the curve (AUC) were calculated to evaluate the efficacy of each model in predicting IPA. Additionally, based on the best-performing model on the LR classifier, four other machine learning (ML) classifiers were constructed to evaluate the predictive value for IPA.

Results: The AUC of the clinic-radiological model for predicting IPA in the training and test sets was 0.845 and 0.765, respectively. The AUC of the radiomics-DL and combined models in the training set was 0.871 and 0.932, while in the test set was 0.851 and 0.881, respectively. The combined model showed better predictive performance than all other models. DCA showed that taking 0.00-1.00 as the threshold, the clinical benefit of the combined model was higher than that of all other models. Then, the combined model was trained on four other machine learning classifiers, all of which achieved AUC values above 0.80 in the test set, showing good performance in predicting IPA.

Conclusion: Clinic, CT radiomics, and DL combined model could be used to predict IPA effectively.

背景:侵袭性肺曲霉菌病(IPA)是一种严重的真菌感染:侵袭性肺曲霉菌病(IPA)是一种严重的真菌感染。然而,目前的诊断方法存在局限性。本研究旨在利用人工智能对 IPA 进行更准确的诊断:方法:从一家机构回顾性招募了263名患者(148例IPA,115例非IPA),并按7:3的比例随机分为训练集和测试集。通过单变量分析和多变量逻辑回归分析筛选出IPA的临床放射学独立危险因素,然后构建临床放射学模型。根据 CT 图像提取和筛选最佳放射组学特征,构建放射组学标签得分(Rad-score)和放射组学模型。使用四个预先训练好的卷积神经网络分别提取和筛选出最佳的 DL 特征,然后构建 DL 标签得分(DL-score)和 DL 模型。然后,构建放射组学-DL 模型。最后,根据临床放射学独立危险因素、Rad-score 和 DL-score,构建综合模型。采用 LR 作为分类器。绘制了接收者操作特征曲线(ROC),并计算了曲线下面积(AUC),以评估各模型预测 IPA 的效果。此外,根据 LR 分类器中表现最好的模型,构建了其他四个机器学习(ML)分类器,以评估对 IPA 的预测价值:在训练集和测试集中,临床-放射学模型预测 IPA 的 AUC 分别为 0.845 和 0.765。放射组学-DL模型和组合模型在训练集中的AUC分别为0.871和0.932,而在测试集中分别为0.851和0.881。综合模型的预测性能优于所有其他模型。DCA 显示,以 0.00-1.00 为阈值,组合模型的临床效益高于所有其他模型。然后,在其他四个机器学习分类器上对组合模型进行训练,在测试集中,所有分类器的AUC值都超过了0.80,显示出在预测IPA方面的良好性能:结论:临床、CT放射组学和 DL 组合模型可用于有效预测 IPA。
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引用次数: 0
Retrospective analysis of multiparametric MRI in predicting complete pathologic response of neo-adjuvant chemotherapy in bladder cancer. 多参数磁共振成像预测膀胱癌新辅助化疗完全病理反应的回顾性分析。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-07 DOI: 10.1186/s12880-024-01441-y
Daan De Maeseneer, Pieter De Visschere, Mats Van den Broecke, Felix Delbare, Geert Villeirs, Sofie Verbeke, Valérie Fonteyne, Charles Van Praet, Karel Decaestecker, Alexander Decruyenaere, Sylvie Rottey

Background: Muscle invasive bladder cancer (MIBC) treatment combines systemic therapy and radical cystectomy (RC) or local (chemo-)radiotherapy. Response to systemic therapy is an important outcome predictor but is difficult to assess pre-operatively.

Methods: We analyzed multiparametric MRI (mpMRI) in consecutive MIBC patients receiving cisplatin-based neo-adjuvant chemotherapy at our institution. Two readers, blinded for pathological outcome, independently scored mpMRI before and after 2 and 4 cycles using both a qualitative 3-step method and nacVI-RADS. We analyzed accuracy of mpMRI scores to predict pathologic complete response (pCR) and inter-observer agreement.

Results: We analyzed 46 patients receiving NAC, 6 patients did not undergo RC after NAC and were excluded. Eleven out of 40 (28%) patients showed a pCR. mpMRI could be assessed in over 90% of patients. Radiologic complete response (rCR) using both methods was significantly associated with pCR, with an overall specificity of 96% and sensitivity of 36% and a high inter-observer agreement. rCR as assessed by the 3-step score was significantly associated with disease free survival (DFS) benefit.

Conclusion: The use of nacVI-RADS can predict pCR after NAC with high specificity but low sensitivity and a high inter-observer agreement. A 3-step score adds value in determining local residual disease, rCR assessed by this method could correlate with DFS benefit. mpMRI scores should be prospectively assessed in future trials of multimodal management of MIBC and can be a predictive asset in routine clinical management.

背景:肌层浸润性膀胱癌(MIBC)的治疗结合了全身治疗和根治性膀胱切除术(RC)或局部(化疗)放疗。对全身治疗的反应是预测疗效的重要指标,但很难在术前进行评估:我们分析了在本院接受顺铂新辅助化疗的连续 MIBC 患者的多参数磁共振成像(mpMRI)。两名病理结果盲法阅读者使用定性三步法和 nacVI-RADS 对 2 个和 4 个周期前后的 mpMRI 独立评分。我们分析了mpMRI评分预测病理完全反应(pCR)的准确性和观察者之间的一致性:我们分析了46名接受NAC治疗的患者,其中6名患者在接受NAC治疗后未进行RC,因此被排除在外。40例患者中有11例(28%)出现了pCR。90%以上的患者可以进行mpMRI评估。使用这两种方法得出的放射学完全反应(rCR)与pCR显著相关,总体特异性为96%,敏感性为36%,观察者之间的一致性很高:结论:使用 nacVI-RADS 可以预测 NAC 后的 pCR,特异性高,但敏感性低,且观察者之间的一致性较高。mpMRI评分应在未来的MIBC多模式管理试验中进行前瞻性评估,并可作为常规临床管理的预测工具。
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引用次数: 0
Predicting response to immunotherapy in oral squamous cell carcinoma via a CT-based radiomics model. 通过基于 CT 的放射组学模型预测口腔鳞状细胞癌对免疫疗法的反应。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-07 DOI: 10.1186/s12880-024-01444-9
Qifan Ma, Jiliang Ren, Rui Wang, Ying Yuan, Xiaofeng Tao

Background: To investigate whether radiomics models derived from pretreatment CT could help to predict response to immunotherapy in oral squamous cell carcinoma (OSCC).

Methods: Retrospectively, a total of 40 patients with measurable OSCC were included. The patients were divided into responder group and non-responder group according to the comparison of pre-treatment and post-treatment CT findings. Radiomics features were extracted from pre-treatment CT images, and optimal features were selected by univariate analysis and the least absolute shrinkage and selection operator (LASSO) regression analysis. Neural network, support vector machine, random forest and logistic regression models were used to predict response to immunotherapy in OSCC, and leave-one-out cross validation was employed to assess the performance of the classifiers. The area under the curve (AUC), accuracy, sensitivity and specificity were calculated to quantify the predictive efficacy.

Results: A total of 7 features were selected to build models upon machine learning methods. By comparing different machine learning based models, the neural network model achieved the best predictive ability, with an AUC of 0.864, an accuracy of 82.5%, a sensitivity of 82.5%, and a specificity of 82.5%.

Conclusions: The pretreatment CT-based radiomics model showed good performance in predicting response to immunotherapy in OSCC. Pretreatment CT-based radiomics model might provide an alternative approach for the selection of patients who benefit from immunotherapy.

背景:研究从治疗前CT得出的放射组学模型是否有助于预测口腔鳞状细胞癌(OSCC)的免疫治疗反应:研究从治疗前CT得出的放射组学模型是否有助于预测口腔鳞状细胞癌(OSCC)对免疫疗法的反应:方法:回顾性纳入40例可测量的OSCC患者。根据治疗前和治疗后CT结果的比较,将患者分为应答组和非应答组。从治疗前的CT图像中提取放射组学特征,并通过单变量分析和最小绝对收缩和选择算子(LASSO)回归分析选出最佳特征。采用神经网络、支持向量机、随机森林和逻辑回归模型来预测OSCC对免疫疗法的反应,并采用leave-one-out交叉验证来评估分类器的性能。通过计算曲线下面积(AUC)、准确率、灵敏度和特异性来量化预测效果:结果:共选取了 7 个特征,利用机器学习方法建立模型。通过比较不同的机器学习模型,神经网络模型的预测能力最佳,其AUC为0.864,准确率为82.5%,灵敏度为82.5%,特异性为82.5%:结论:基于治疗前CT的放射组学模型在预测OSCC对免疫疗法的反应方面表现良好。结论:基于治疗前CT的放射组学模型在预测OSCC对免疫疗法的反应方面表现良好,它可能为选择免疫疗法受益患者提供了另一种方法。
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引用次数: 0
Artificial intelligence in predicting recurrence after first-line treatment of liver cancer: a systematic review and meta-analysis. 人工智能预测肝癌一线治疗后的复发:系统综述和荟萃分析。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-07 DOI: 10.1186/s12880-024-01440-z
Linyong Wu, Qingfeng Lai, Songhua Li, Shaofeng Wu, Yizhong Li, Ju Huang, Qiuli Zeng, Dayou Wei

Background: The aim of this study was to conduct a systematic review and meta-analysis to comprehensively evaluate the performance and methodological quality of artificial intelligence (AI) in predicting recurrence after single first-line treatment for liver cancer.

Methods: A rigorous and systematic evaluation was conducted on the AI studies related to recurrence after single first-line treatment for liver cancer, retrieved from the PubMed, Embase, Web of Science, Cochrane Library, and CNKI databases. The area under the curve (AUC), sensitivity (SENC), and specificity (SPEC) of each study were extracted for meta-analysis.

Results: Six percutaneous ablation (PA) studies, 16 surgical resection (SR) studies, and 5 transarterial chemoembolization (TACE) studies were included in the meta-analysis for predicting recurrence after hepatocellular carcinoma (HCC) treatment, respectively. Four SR studies and 2 PA studies were included in the meta-analysis for recurrence after intrahepatic cholangiocarcinoma (ICC) and colorectal cancer liver metastasis (CRLM) treatment. The pooled SENC, SEPC, and AUC of AI in predicting recurrence after primary HCC treatment via PA, SR, and TACE were 0.78, 0.90, and 0.92; 0.81, 0.77, and 0.86; and 0.73, 0.79, and 0.79, respectively. The values for ICC treated with SR and CRLM treated with PA were 0.85, 0.71, 0.86 and 0.69, 0.63,0.74, respectively.

Conclusion: This systematic review and meta-analysis demonstrates the comprehensive application value of AI in predicting recurrence after a single first-line treatment of liver cancer, with satisfactory results, indicating the clinical translation potential of AI in predicting recurrence after liver cancer treatment.

研究背景本研究旨在进行系统综述和荟萃分析,以全面评估人工智能(AI)在预测肝癌单次一线治疗后复发方面的性能和方法学质量:对从PubMed、Embase、Web of Science、Cochrane Library和CNKI数据库中检索到的与肝癌单次一线治疗后复发相关的人工智能研究进行了严格而系统的评估。提取每项研究的曲线下面积(AUC)、敏感性(SENC)和特异性(SPEC)进行荟萃分析:结果:6 项经皮消融术(PA)研究、16 项手术切除术(SR)研究和 5 项经动脉化疗栓塞术(TACE)研究分别被纳入了预测肝细胞癌(HCC)治疗后复发的荟萃分析。针对肝内胆管癌(ICC)和结直肠癌肝转移(CRLM)治疗后复发的荟萃分析纳入了 4 项 SR 研究和 2 项 PA 研究。AI预测PA、SR和TACE治疗原发性HCC后复发的汇总SENC、SEPC和AUC分别为0.78、0.90和0.92;0.81、0.77和0.86;0.73、0.79和0.79。SR治疗的ICC和PA治疗的CRLM的数值分别为0.85、0.71、0.86和0.69、0.63、0.74:本系统综述和荟萃分析展示了人工智能在预测肝癌单次一线治疗后复发的综合应用价值,结果令人满意,表明人工智能在预测肝癌治疗后复发方面具有临床转化潜力。
{"title":"Artificial intelligence in predicting recurrence after first-line treatment of liver cancer: a systematic review and meta-analysis.","authors":"Linyong Wu, Qingfeng Lai, Songhua Li, Shaofeng Wu, Yizhong Li, Ju Huang, Qiuli Zeng, Dayou Wei","doi":"10.1186/s12880-024-01440-z","DOIUrl":"10.1186/s12880-024-01440-z","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to conduct a systematic review and meta-analysis to comprehensively evaluate the performance and methodological quality of artificial intelligence (AI) in predicting recurrence after single first-line treatment for liver cancer.</p><p><strong>Methods: </strong>A rigorous and systematic evaluation was conducted on the AI studies related to recurrence after single first-line treatment for liver cancer, retrieved from the PubMed, Embase, Web of Science, Cochrane Library, and CNKI databases. The area under the curve (AUC), sensitivity (SENC), and specificity (SPEC) of each study were extracted for meta-analysis.</p><p><strong>Results: </strong>Six percutaneous ablation (PA) studies, 16 surgical resection (SR) studies, and 5 transarterial chemoembolization (TACE) studies were included in the meta-analysis for predicting recurrence after hepatocellular carcinoma (HCC) treatment, respectively. Four SR studies and 2 PA studies were included in the meta-analysis for recurrence after intrahepatic cholangiocarcinoma (ICC) and colorectal cancer liver metastasis (CRLM) treatment. The pooled SENC, SEPC, and AUC of AI in predicting recurrence after primary HCC treatment via PA, SR, and TACE were 0.78, 0.90, and 0.92; 0.81, 0.77, and 0.86; and 0.73, 0.79, and 0.79, respectively. The values for ICC treated with SR and CRLM treated with PA were 0.85, 0.71, 0.86 and 0.69, 0.63,0.74, respectively.</p><p><strong>Conclusion: </strong>This systematic review and meta-analysis demonstrates the comprehensive application value of AI in predicting recurrence after a single first-line treatment of liver cancer, with satisfactory results, indicating the clinical translation potential of AI in predicting recurrence after liver cancer treatment.</p>","PeriodicalId":9020,"journal":{"name":"BMC Medical Imaging","volume":"24 1","pages":"263"},"PeriodicalIF":2.9,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MRI T2WI-based radiomics combined with KRAS gene mutation constructed models for predicting liver metastasis in rectal cancer. 基于核磁共振 T2WI 的放射组学结合 KRAS 基因突变构建的直肠癌肝转移预测模型
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-04 DOI: 10.1186/s12880-024-01439-6
Jiaqi Ma, Xinsheng Nie, Xiangjiang Kong, Lingqing Xiao, Han Liu, Shengming Shi, Yupeng Wu, Na Li, Linlin Hu, Xiaofu Li

Background: The study aimed to identify the optimal model for predicting rectal cancer liver metastasis (RCLM). This involved constructing various prediction models to aid clinicians in early diagnosis and precise decision-making.

Methods: A retrospective analysis was conducted on 193 patients diagnosed with rectal adenocarcinoma were randomly divided into training set (n = 136) and validation set (n = 57) at a ratio of 7:3. The predictive performance of three models was internally validated by 10-fold cross-validation in the training set. Delineation of the tumor region of interest (ROI) was performed, followed by the extraction of radiomics features from the ROI. The least absolute shrinkage and selection operator (LASSO) regression algorithm and multivariate Cox analysis were employed to reduce the dimensionality of radiomics features and identify significant features. Logistic regression was employed to construct three prediction models: clinical, radiomics, and combined models (radiomics + clinical). The predictive performance of each model was assessed and compared.

Results: KRAS mutation emerged as an independent predictor of liver metastasis, yielding an odds ratio (OR) of 8.296 (95%CI: 3.471-19.830; p < 0.001). 5 radiomics features will be used to construct radiomics model. The combined model was built by integrating radiomics model with clinical model. In both the training set (AUC:0.842, 95%CI: 0.778-0.907) and the validation set (AUC: 0.805; 95%CI: 0.692-0.918), the AUCs for the combined model surpassed those of the radiomics and clinical models.

Conclusions: Our study reveals that KRAS mutation stands as an independent predictor of RCLM. The radiomics features based on MR play a crucial role in the evaluation of RCLM. The combined model exhibits superior performance in the prediction of liver metastasis.

Clinical trial number: Not applicable.

研究背景该研究旨在确定预测直肠癌肝转移(RCLM)的最佳模型。这包括构建各种预测模型,以帮助临床医生进行早期诊断和精确决策:方法:对193名确诊为直肠腺癌的患者进行了回顾性分析,按7:3的比例随机分为训练集(n = 136)和验证集(n = 57)。三个模型的预测性能在训练集中通过 10 倍交叉验证进行了内部验证。首先划分肿瘤感兴趣区(ROI),然后从感兴趣区提取放射组学特征。采用最小绝对收缩和选择算子(LASSO)回归算法和多变量考克斯分析来降低放射组学特征的维度,并识别重要特征。Logistic 回归用于构建三种预测模型:临床模型、放射组学模型和组合模型(放射组学 + 临床)。对每个模型的预测性能进行了评估和比较:结果:KRAS突变是肝转移的独立预测因子,其几率比(OR)为8.296(95%CI:3.471-19.830;P 结论:我们的研究揭示了KRAS突变对肝转移的影响:我们的研究表明,KRAS 突变是 RCLM 的独立预测因素。基于 MR 的放射组学特征在 RCLM 的评估中起着至关重要的作用。综合模型在预测肝转移方面表现出卓越的性能:不适用。
{"title":"MRI T2WI-based radiomics combined with KRAS gene mutation constructed models for predicting liver metastasis in rectal cancer.","authors":"Jiaqi Ma, Xinsheng Nie, Xiangjiang Kong, Lingqing Xiao, Han Liu, Shengming Shi, Yupeng Wu, Na Li, Linlin Hu, Xiaofu Li","doi":"10.1186/s12880-024-01439-6","DOIUrl":"10.1186/s12880-024-01439-6","url":null,"abstract":"<p><strong>Background: </strong>The study aimed to identify the optimal model for predicting rectal cancer liver metastasis (RCLM). This involved constructing various prediction models to aid clinicians in early diagnosis and precise decision-making.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 193 patients diagnosed with rectal adenocarcinoma were randomly divided into training set (n = 136) and validation set (n = 57) at a ratio of 7:3. The predictive performance of three models was internally validated by 10-fold cross-validation in the training set. Delineation of the tumor region of interest (ROI) was performed, followed by the extraction of radiomics features from the ROI. The least absolute shrinkage and selection operator (LASSO) regression algorithm and multivariate Cox analysis were employed to reduce the dimensionality of radiomics features and identify significant features. Logistic regression was employed to construct three prediction models: clinical, radiomics, and combined models (radiomics + clinical). The predictive performance of each model was assessed and compared.</p><p><strong>Results: </strong>KRAS mutation emerged as an independent predictor of liver metastasis, yielding an odds ratio (OR) of 8.296 (95%CI: 3.471-19.830; p < 0.001). 5 radiomics features will be used to construct radiomics model. The combined model was built by integrating radiomics model with clinical model. In both the training set (AUC:0.842, 95%CI: 0.778-0.907) and the validation set (AUC: 0.805; 95%CI: 0.692-0.918), the AUCs for the combined model surpassed those of the radiomics and clinical models.</p><p><strong>Conclusions: </strong>Our study reveals that KRAS mutation stands as an independent predictor of RCLM. The radiomics features based on MR play a crucial role in the evaluation of RCLM. The combined model exhibits superior performance in the prediction of liver metastasis.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9020,"journal":{"name":"BMC Medical Imaging","volume":"24 1","pages":"262"},"PeriodicalIF":2.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11453062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive value of dynamic diffusion tensor imaging for surgical outcomes in patients with cervical spondylotic myelopathy. 动态弥散张量成像对颈椎病患者手术效果的预测价值。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-01 DOI: 10.1186/s12880-024-01428-9
Xiaoyun Wang, Xiaonan Tian, Yujin Zhang, Baogen Zhao, Ning Wang, Ting Gao, Li Zhang

Background: Cervical spondylotic myelopathy (CSM) is the most common chronic spinal cord injury with poor surgical and neurologic recovery in the advanced stages of the disease. DTI parameters can serve as important biomarkers for CSM prognosis. The study aimed to investigate the predictive value of dynamic diffusion tensor imaging (DTI) for the postoperative outcomes of CSM.

Methods: One hundred and five patients with CSM who underwent surgery were included in this study. Patients were assessed using the Modified Japanese Orthopedic Association Score (mJOA) before and one year after surgery and then divided into groups with good (≥ 50%) and poor (< 50%) prognoses according to the rate of recovery. All patients underwent preoperative dynamic magnetic resonance imaging of the cervical spine, including T2WI and DTI in natural(N), extension (E), and flexion (F) positions. ROM, Cross-sectional area, fractional anisotropy (FA), and apparent diffusion coefficient (ADC) were measured at the narrowest level in three neck positions. Univariate and multivariate logistic regression were used to identify risk factors for poor postoperative recovery based on clinical characteristics, dynamic T2WI, and DTI parameters. Predictive models were developed for three different neck positions.

Results: Forty-four (41.9%) patients had a good postoperative prognosis, and 61 (58.1%) had a poor prognosis. Univariate analysis showed statistically significant differences in diabetes, number of compression segments, preoperative mJOA score, cross-sectional area ((Area-N), (Area-E), (Area-F)), ADC((ADC-N), (ADC-E), (ADC-F)) and FA (((FA-N), (FA-E), (FA-F)) (p < 0.05). Multivariable logistic regression showed that natural neck position: Area-N ([OR] 0.226; [CI] 0.069-0.732, p = 0.013),FA-N([OR]3.028;[CI]1.12-8.19,p = 0.029); extension ne-ck position: Area-E([OR]0.248;[CI]0.076-0.814,p = 0.021), FA-E([OR]4.793;[CI]1.737-13.228,p = 0.002);And flextion neck postion: Area-F([OR] 0.288; [CI] 0.095-0.87, p = 0.027),FA-F ([OR] 2.964; [CI] 1.126-7.801, p = 0.028) were independent risk factors for poor prognosis.The area under the curve (AUC) of the prediction models in the natural neck position, extension neck position, and flexion neck positions models were 0.708[(95% CI:0.608∼0.808), P < 0.001]; 0.738 [(95% CI:0.641∼0.835), P < 0.001]; 0.703 [(95% CI:0.602∼0.803), P < 0.001], respectively.

Conclusion: Dynamic DTI can predict postoperative outcomes in CSM. Reduced FA in the extension position is a valid predictor of poor postoperative neurological recovery in patients with CSM.

背景:颈椎病(CSM)是最常见的慢性脊髓损伤,疾病晚期的手术和神经功能恢复较差。DTI 参数可作为 CSM 预后的重要生物标志物。本研究旨在探讨动态弥散张量成像(DTI)对CSM术后预后的预测价值:本研究共纳入了 105 名接受手术的 CSM 患者。方法:该研究纳入了 105 名接受手术治疗的 CSM 患者,在术前和术后一年使用改良日本骨科协会评分(mJOA)对患者进行评估,然后将患者分为良好组(≥ 50%)和不良组(结果:44 例(41.9%)患者的术后疗效为良好(≥ 50%):44例(41.9%)患者术后预后良好,61例(58.1%)预后不良。单变量分析显示,糖尿病、压迫节段数、术前 mJOA 评分、横截面积((Area-N)、(Area-E)、(Area-F))、ADC((ADC-N)、(ADC-E)、(ADC-F))和 FA(((FA-N)、(FA-E)、(FA-F))存在显著统计学差异(P 结论:动态 DTI 可以预测术后预后:动态 DTI 可以预测 CSM 的术后结果。伸展位的 FA 值降低是 CSM 患者术后神经功能恢复不良的有效预测指标。
{"title":"Predictive value of dynamic diffusion tensor imaging for surgical outcomes in patients with cervical spondylotic myelopathy.","authors":"Xiaoyun Wang, Xiaonan Tian, Yujin Zhang, Baogen Zhao, Ning Wang, Ting Gao, Li Zhang","doi":"10.1186/s12880-024-01428-9","DOIUrl":"10.1186/s12880-024-01428-9","url":null,"abstract":"<p><strong>Background: </strong>Cervical spondylotic myelopathy (CSM) is the most common chronic spinal cord injury with poor surgical and neurologic recovery in the advanced stages of the disease. DTI parameters can serve as important biomarkers for CSM prognosis. The study aimed to investigate the predictive value of dynamic diffusion tensor imaging (DTI) for the postoperative outcomes of CSM.</p><p><strong>Methods: </strong>One hundred and five patients with CSM who underwent surgery were included in this study. Patients were assessed using the Modified Japanese Orthopedic Association Score (mJOA) before and one year after surgery and then divided into groups with good (≥ 50%) and poor (< 50%) prognoses according to the rate of recovery. All patients underwent preoperative dynamic magnetic resonance imaging of the cervical spine, including T2WI and DTI in natural(N), extension (E), and flexion (F) positions. ROM, Cross-sectional area, fractional anisotropy (FA), and apparent diffusion coefficient (ADC) were measured at the narrowest level in three neck positions. Univariate and multivariate logistic regression were used to identify risk factors for poor postoperative recovery based on clinical characteristics, dynamic T2WI, and DTI parameters. Predictive models were developed for three different neck positions.</p><p><strong>Results: </strong>Forty-four (41.9%) patients had a good postoperative prognosis, and 61 (58.1%) had a poor prognosis. Univariate analysis showed statistically significant differences in diabetes, number of compression segments, preoperative mJOA score, cross-sectional area ((Area-N), (Area-E), (Area-F)), ADC((ADC-N), (ADC-E), (ADC-F)) and FA (((FA-N), (FA-E), (FA-F)) (p < 0.05). Multivariable logistic regression showed that natural neck position: Area-N ([OR] 0.226; [CI] 0.069-0.732, p = 0.013),FA-N([OR]3.028;[CI]1.12-8.19,p = 0.029); extension ne-ck position: Area-E([OR]0.248;[CI]0.076-0.814,p = 0.021), FA-E([OR]4.793;[CI]1.737-13.228,p = 0.002);And flextion neck postion: Area-F([OR] 0.288; [CI] 0.095-0.87, p = 0.027),FA-F ([OR] 2.964; [CI] 1.126-7.801, p = 0.028) were independent risk factors for poor prognosis.The area under the curve (AUC) of the prediction models in the natural neck position, extension neck position, and flexion neck positions models were 0.708[(95% CI:0.608∼0.808), P < 0.001]; 0.738 [(95% CI:0.641∼0.835), P < 0.001]; 0.703 [(95% CI:0.602∼0.803), P < 0.001], respectively.</p><p><strong>Conclusion: </strong>Dynamic DTI can predict postoperative outcomes in CSM. Reduced FA in the extension position is a valid predictor of poor postoperative neurological recovery in patients with CSM.</p>","PeriodicalId":9020,"journal":{"name":"BMC Medical Imaging","volume":"24 1","pages":"260"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the clinical application value of artificial intelligence in diagnosing head and neck aneurysms. 评估人工智能在诊断头颈部动脉瘤中的临床应用价值。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-01 DOI: 10.1186/s12880-024-01436-9
Yi Shen, Chao Zhu, Bingqian Chu, Jian Song, Yayuan Geng, Jianying Li, Bin Liu, Xingwang Wu

Objective: To evaluate the performance of a semi-automated artificial intelligence (AI) software program (CerebralDoc® system) in aneurysm detection and morphological measurement.

Methods: In this study, 354 cases of computed tomographic angiography (CTA) were retrospectively collected in our hospital. Among them, 280 cases were diagnosed with aneurysms by either digital subtraction angiography (DSA) and CTA (DSA group, n = 102), or CTA-only (non-DSA group, n = 178). The presence or absence of aneurysms, as well as their location and related morphological features determined by AI were evaluated using DSA and radiologist findings. Besides, post-processing image quality from AI and radiologists were also rated and compared.

Results: In the DSA group, AI achieved a sensitivity of 88.24% and an accuracy of 81.97%, whereas radiologists achieved a sensitivity of 95.10% and an accuracy of 84.43%, using DSA results as the gold standard. The AI in the non-DSA group achieved 81.46% sensitivity and 76.29% accuracy, as per the radiologists' findings. The comparison of position consistency results showed better performance under loose criteria than strict criteria. In terms of morphological characteristics, both the DSA and the non-DSA groups agreed well with the diagnostic results for neck width and maximum diameter, demonstrating excellent ICC reliability exceeding 0.80. The AI-generated images exhibited superior quality compared to the standard software for post-processing, while also demonstrating a significantly reduced processing time.

Conclusions: The AI-based aneurysm detection rate demonstrates a commendable performance, while the extracted morphological parameters exhibit a remarkable consistency with those assessed by radiologists, thereby showcasing significant potential for clinical application.

目的评估半自动人工智能(AI)软件程序(CerebralDoc® 系统)在动脉瘤检测和形态测量中的性能:本研究回顾性收集了本院 354 例计算机断层扫描血管造影(CTA)病例。其中,280 例通过数字减影血管造影(DSA)和 CTA(DSA 组,102 例)或仅 CTA(非 DSA 组,178 例)确诊为动脉瘤。根据 DSA 和放射科医生的检查结果评估动脉瘤的存在与否,以及 AI 确定的动脉瘤位置和相关形态特征。此外,还对人工智能和放射科医生的后处理图像质量进行了评价和比较:以 DSA 结果为金标准,在 DSA 组中,人工智能的灵敏度为 88.24%,准确率为 81.97%,而放射医师的灵敏度为 95.10%,准确率为 84.43%。非 DSA 组的人工智能灵敏度为 81.46%,准确率为 76.29%,与放射科医生的结果一致。位置一致性结果比较显示,宽松标准比严格标准的性能更好。在形态学特征方面,DSA 组和非 DSA 组在颈部宽度和最大直径方面的诊断结果都非常一致,显示出超过 0.80 的出色 ICC 可靠性。与用于后处理的标准软件相比,人工智能生成的图像显示出更高的质量,同时还显著缩短了处理时间:结论:基于人工智能的动脉瘤检测率表现值得称赞,同时提取的形态学参数与放射科医生评估的参数表现出显著的一致性,从而展示了临床应用的巨大潜力。
{"title":"Evaluation of the clinical application value of artificial intelligence in diagnosing head and neck aneurysms.","authors":"Yi Shen, Chao Zhu, Bingqian Chu, Jian Song, Yayuan Geng, Jianying Li, Bin Liu, Xingwang Wu","doi":"10.1186/s12880-024-01436-9","DOIUrl":"10.1186/s12880-024-01436-9","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the performance of a semi-automated artificial intelligence (AI) software program (CerebralDoc<sup>®</sup> system) in aneurysm detection and morphological measurement.</p><p><strong>Methods: </strong>In this study, 354 cases of computed tomographic angiography (CTA) were retrospectively collected in our hospital. Among them, 280 cases were diagnosed with aneurysms by either digital subtraction angiography (DSA) and CTA (DSA group, n = 102), or CTA-only (non-DSA group, n = 178). The presence or absence of aneurysms, as well as their location and related morphological features determined by AI were evaluated using DSA and radiologist findings. Besides, post-processing image quality from AI and radiologists were also rated and compared.</p><p><strong>Results: </strong>In the DSA group, AI achieved a sensitivity of 88.24% and an accuracy of 81.97%, whereas radiologists achieved a sensitivity of 95.10% and an accuracy of 84.43%, using DSA results as the gold standard. The AI in the non-DSA group achieved 81.46% sensitivity and 76.29% accuracy, as per the radiologists' findings. The comparison of position consistency results showed better performance under loose criteria than strict criteria. In terms of morphological characteristics, both the DSA and the non-DSA groups agreed well with the diagnostic results for neck width and maximum diameter, demonstrating excellent ICC reliability exceeding 0.80. The AI-generated images exhibited superior quality compared to the standard software for post-processing, while also demonstrating a significantly reduced processing time.</p><p><strong>Conclusions: </strong>The AI-based aneurysm detection rate demonstrates a commendable performance, while the extracted morphological parameters exhibit a remarkable consistency with those assessed by radiologists, thereby showcasing significant potential for clinical application.</p>","PeriodicalId":9020,"journal":{"name":"BMC Medical Imaging","volume":"24 1","pages":"261"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual stage MRI image restoration based on blind spot denoising and hybrid attention. 基于盲点去噪和混合注意力的双级磁共振成像修复
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-28 DOI: 10.1186/s12880-024-01437-8
Renfeng Liu, Songyan Xiao, Tianwei Liu, Fei Jiang, Cao Yuan, Jianfeng Chen

Background: Magnetic Resonance Imaging (MRI) is extensively utilized in clinical diagnostics and medical research, yet the imaging process is often compromised by noise interference. This noise arises from various sources, leading to a reduction in image quality and subsequently hindering the accurate interpretation of image details by clinicians. Traditional denoising methods typically assume that noise follows a Gaussian distribution, thereby neglecting the more complex noise types present in MRI images, such as Rician noise. As a result, denoising remains a challenging and practical task.

Method: The main research work of this paper focuses on modifying mask information based on a global mask mapper. The mask mapper samples all blind spot pixels on the denoised image and maps them to the same channel. By incorporating perceptual loss, it utilizes all available information to improve performance while avoiding identity mapping. During the denoising process, the model may mistakenly remove some useful information as noise, resulting in a loss of detail in the denoised image. To address this issue, we train a generative adversarial network (GAN) with adaptive hybrid attention to restore the detailed information in the denoised MRI images.

Result: The two-stage model NRAE shows an improvement of nearly 1.4 dB in PSNR and approximately 0.1 in SSIM on clinical datasets compared to other classic models. Specifically, compared to the baseline model, PSNR is increased by about 0.6 dB, and SSIM is only 0.015 lower. From a visual perspective, NRAE more effectively restores the details in the images, resulting in richer and clearer representation of image details.

Conclusion: We have developed a deep learning-based two-stage model to address noise issues in medical MRI images. This method not only successfully reduces noise signals but also effectively restores anatomical details. The current results indicate that this is a promising approach. In future work, we plan to replace the current denoising network with more advanced models to further enhance performance.

背景:磁共振成像(MRI)被广泛应用于临床诊断和医学研究,但成像过程经常受到噪声干扰。这些噪声来源多样,会导致图像质量下降,进而妨碍临床医生准确解读图像细节。传统的去噪方法通常假定噪声服从高斯分布,从而忽略了磁共振成像中存在的更复杂的噪声类型,如里昂噪声。因此,去噪仍然是一项具有挑战性的实际任务:本文的主要研究工作是基于全局掩膜映射器修改掩膜信息。掩膜映射器对去噪图像上的所有盲点像素进行采样,并将它们映射到同一通道。通过结合感知损失,它可以利用所有可用信息来提高性能,同时避免身份映射。在去噪过程中,模型可能会错误地将一些有用的信息作为噪声去除,导致去噪图像细节丢失。为了解决这个问题,我们训练了一个具有自适应混合注意力的生成对抗网络(GAN),以恢复去噪核磁共振图像中的细节信息:与其他经典模型相比,两阶段模型 NRAE 在临床数据集上的 PSNR 提高了近 1.4 dB,SSIM 提高了约 0.1。具体来说,与基线模型相比,PSNR 提高了约 0.6 dB,SSIM 仅降低了 0.015。从视觉角度来看,NRAE 能更有效地还原图像中的细节,从而更丰富、更清晰地呈现图像细节:我们开发了一种基于深度学习的两阶段模型来解决医学核磁共振图像中的噪声问题。这种方法不仅能成功降低噪声信号,还能有效还原解剖细节。目前的结果表明,这是一种很有前景的方法。在未来的工作中,我们计划用更先进的模型取代当前的去噪网络,以进一步提高性能。
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引用次数: 0
Diagnosis of suspected pediatric distal forearm fractures with point-of-care-ultrasound (POCUS) by pediatric orthopedic surgeons after minimal training. 小儿骨科外科医生经过最低限度的培训后,利用护理点超声 (POCUS) 诊断疑似小儿前臂远端骨折。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-27 DOI: 10.1186/s12880-024-01433-y
Josephine Edith Pohl, Philipp Schwerk, René Mauer, Gabriele Hahn, Ricardo Beck, Guido Fitze, Jurek Schultz

Background: Several studies have advocated the use of ultrasound to diagnose distal forearm fractures in children. However, there is limited data on the diagnostic accuracy of ultrasound for distal forearm fractures when conducted by pediatric surgeons or trainees who manage orthopedic injuries in children. The objective of this study was to determine the diagnostic accuracy of point-of-care ultrasound (POCUS) for pediatric distal forearm fractures when conducted by pediatric surgeons and trainees after minimal training.

Methods: This diagnostic study was conducted in a tertiary hospital emergency department in Germany. Participants were children and adolescents under 15 years of age who presented to the emergency department with an acute, suspected, isolated distal forearm fracture requiring imaging. Pediatric surgeons and trainees, after minimal training for sonographic fracture diagnosis, performed 6-view distal forearm POCUS on each participant prior to X-ray imaging. All data was retrospectively collected from the hospital's routine digital patient files. The primary outcome was the diagnostic accuracy of POCUS compared to X-ray as the reference standard.

Results: From February to June 2021, 146 children under 15 met all inclusion and exclusion criteria, and 106 data sets were available for analysis. Regarding the presence of a fracture, X-ray and Wrist-POCUS showed the same result in 99.1%, with 83/106 (78.3%) fractures detected in both modalities and one suspected buckle fracture on POCUS not confirmed in the radiographs. Wrist-POCUS had a sensitivity of 100% (95% CI [0.956, 1]) and a specificity of 95.8% (95% CI [0.789, 0.999]) compared to radiographs. In 6 cases, there were minor differences regarding a concomitant ulnar buckle. The amount of prior ultrasound training had no influence on the accuracy of Wrist-POCUS for diagnosing distal forearm fractures. All fractures were reliably diagnosed even when captured POCUS images did not meet all quality criteria.

Conclusion: Pediatric surgeons and trainees, after minimal training in POCUS, had excellent diagnostic accuracy for distal forearm fractures in children and adolescents using POCUS compared to X-ray.

背景:多项研究提倡使用超声波诊断儿童前臂远端骨折。然而,由儿科外科医生或管理儿童骨科损伤的受训人员对前臂远端骨折进行超声诊断的准确性数据却很有限。本研究的目的是确定儿科外科医生和受训人员在经过最低限度的培训后对小儿前臂远端骨折进行护理点超声(POCUS)诊断的准确性:这项诊断研究在德国一家三级医院急诊科进行。参与者为 15 岁以下的儿童和青少年,他们因急性、疑似、孤立性前臂远端骨折而到急诊科就诊,需要进行影像学检查。小儿外科医生和受训人员在接受了最基本的骨折声学诊断培训后,在进行X光成像前对每位受试者进行了6视角前臂远端POCUS检查。所有数据均从医院的常规数字患者档案中进行回顾性收集。主要结果是与作为参考标准的X光相比,POCUS的诊断准确性:2021年2月至6月,146名15岁以下儿童符合所有纳入和排除标准,106组数据可供分析。关于是否存在骨折,X射线和腕部POCUS显示99.1%的结果相同,其中83/106(78.3%)的骨折在两种模式下均可检测到,POCUS显示的1处疑似扣骨骨折未在X射线照片中得到证实。与X光片相比,腕部POCUS的灵敏度为100%(95% CI [0.956,1]),特异性为95.8%(95% CI [0.789,0.999])。在 6 个病例中,并发尺骨扣的情况略有不同。之前接受过多少超声培训对 Wrist-POCUS 诊断前臂远端骨折的准确性没有影响。即使采集的POCUS图像不符合所有质量标准,所有骨折都能得到可靠诊断:结论:小儿外科医生和受训人员在接受过最低限度的 POCUS 培训后,使用 POCUS 诊断儿童和青少年前臂远端骨折的准确性优于 X 光检查。
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引用次数: 0
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BMC Medical Imaging
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