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Multimodal medical image fusion based on interval gradients and convolutional neural networks. 基于区间梯度和卷积神经网络的多模态医学图像融合。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-05 DOI: 10.1186/s12880-024-01418-x
Xiaolong Gu, Ying Xia, Jie Zhang

Many image fusion methods have been proposed to leverage the advantages of functional and anatomical images while compensating for their shortcomings. These methods integrate functional and anatomical images while presenting physiological and metabolic organ information, making their diagnostic efficiency far greater than that of single-modal images. Currently, most existing multimodal medical imaging fusion methods are based on multiscale transformation, which involves obtaining pyramid features through multiscale transformation. Low-resolution images are used to analyse approximate image features, and high-resolution images are used to analyse detailed image features. Different fusion rules are applied to achieve feature fusion at different scales. Although these fusion methods based on multiscale transformation can effectively achieve multimodal medical image fusion, much detailed information is lost during multiscale and inverse transformation, resulting in blurred edges and a loss of detail in the fusion images. A multimodal medical image fusion method based on interval gradients and convolutional neural networks is proposed to overcome this problem. First, this method uses interval gradients for image decomposition to obtain structure and texture images. Second, deep neural networks are used to extract perception images. Three methods are used to fuse structure, texture, and perception images. Last, the images are combined to obtain the final fusion image after colour transformation. Compared with the reference algorithms, the proposed method performs better in multiple objective indicators of Q EN , Q NIQE , Q SD , Q SSEQ and Q TMQI .

人们提出了许多图像融合方法,以充分利用功能图像和解剖图像的优势,同时弥补它们的不足。这些方法整合了功能和解剖图像,同时呈现了生理和代谢器官信息,使其诊断效率远远高于单模态图像。目前,现有的多模态医学成像融合方法大多基于多尺度变换,即通过多尺度变换获得金字塔特征。低分辨率图像用于分析近似图像特征,高分辨率图像用于分析详细图像特征。不同的融合规则用于实现不同尺度的特征融合。虽然这些基于多尺度变换的融合方法能有效实现多模态医学图像融合,但在多尺度变换和反变换过程中会丢失很多细节信息,导致融合图像的边缘模糊和细节丢失。为了克服这一问题,本文提出了一种基于区间梯度和卷积神经网络的多模态医学图像融合方法。首先,该方法使用区间梯度进行图像分解,以获得结构和纹理图像。其次,利用深度神经网络提取感知图像。使用三种方法融合结构、纹理和感知图像。最后,图像经过色彩转换后得到最终的融合图像。与参考算法相比,所提出的方法在 Q EN、Q NIQE、Q SD、Q SSEQ 和 Q TMQI 等多个客观指标上表现更好。
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引用次数: 0
Revolutionizing breast ultrasound diagnostics with EfficientNet-B7 and Explainable AI. 利用 EfficientNet-B7 和可解释人工智能革新乳腺超声诊断。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-02 DOI: 10.1186/s12880-024-01404-3
M Latha, P Santhosh Kumar, R Roopa Chandrika, T R Mahesh, V Vinoth Kumar, Suresh Guluwadi

Breast cancer is a leading cause of mortality among women globally, necessitating precise classification of breast ultrasound images for early diagnosis and treatment. Traditional methods using CNN architectures such as VGG, ResNet, and DenseNet, though somewhat effective, often struggle with class imbalances and subtle texture variations, leading to reduced accuracy for minority classes such as malignant tumors. To address these issues, we propose a methodology that leverages EfficientNet-B7, a scalable CNN architecture, combined with advanced data augmentation techniques to enhance minority class representation and improve model robustness. Our approach involves fine-tuning EfficientNet-B7 on the BUSI dataset, implementing RandomHorizontalFlip, RandomRotation, and ColorJitter to balance the dataset and improve model robustness. The training process includes early stopping to prevent overfitting and optimize performance metrics. Additionally, we integrate Explainable AI (XAI) techniques, such as Grad-CAM, to enhance the interpretability and transparency of the model's predictions, providing visual and quantitative insights into the features and regions of ultrasound images influencing classification outcomes. Our model achieves a classification accuracy of 99.14%, significantly outperforming existing CNN-based approaches in breast ultrasound image classification. The incorporation of XAI techniques enhances our understanding of the model's decision-making process, thereby increasing its reliability and facilitating clinical adoption. This comprehensive framework offers a robust and interpretable tool for the early detection and diagnosis of breast cancer, advancing the capabilities of automated diagnostic systems and supporting clinical decision-making processes.

乳腺癌是全球妇女死亡的主要原因,因此有必要对乳腺超声图像进行精确分类,以便早期诊断和治疗。使用 VGG、ResNet 和 DenseNet 等 CNN 架构的传统方法虽然有一定的效果,但往往难以解决类别不平衡和微妙纹理变化的问题,导致恶性肿瘤等少数类别的准确性降低。为了解决这些问题,我们提出了一种方法,利用 EfficientNet-B7(一种可扩展的 CNN 架构)与先进的数据增强技术相结合,来增强少数类别的代表性并提高模型的鲁棒性。我们的方法包括在 BUSI 数据集上微调 EfficientNet-B7,实施 RandomHorizontalFlip、RandomRotation 和 ColorJitter,以平衡数据集并提高模型的鲁棒性。训练过程包括早期停止,以防止过拟合并优化性能指标。此外,我们还整合了可解释人工智能(XAI)技术,如 Grad-CAM,以增强模型预测的可解释性和透明度,为影响分类结果的超声图像特征和区域提供可视化和定量的见解。我们的模型达到了 99.14% 的分类准确率,明显优于现有的基于 CNN 的乳腺超声图像分类方法。XAI 技术的融入增强了我们对模型决策过程的理解,从而提高了模型的可靠性,促进了临床应用。这个综合框架为乳腺癌的早期检测和诊断提供了一个稳健且可解释的工具,提高了自动诊断系统的能力,并为临床决策过程提供了支持。
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引用次数: 0
Fractional differentiation based image enhancement for automatic detection of malignant melanoma. 基于分数分化的图像增强技术自动检测恶性黑色素瘤
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-02 DOI: 10.1186/s12880-024-01400-7
Basmah Anber, Kamil Yurtkan

Recent improvements in artificial intelligence and computer vision make it possible to automatically detect abnormalities in medical images. Skin lesions are one broad class of them. There are types of lesions that cause skin cancer, again with several types. Melanoma is one of the deadliest types of skin cancer. Its early diagnosis is at utmost importance. The treatments are greatly aided with artificial intelligence by the quick and precise diagnosis of these conditions. The identification and delineation of boundaries inside skin lesions have shown promise when using the basic image processing approaches for edge detection. Further enhancements regarding edge detections are possible. In this paper, the use of fractional differentiation for improved edge detection is explored on the application of skin lesion detection. A framework based on fractional differential filters for edge detection in skin lesion images is proposed that can improve automatic detection rate of malignant melanoma. The derived images are used to enhance the input images. Obtained images then undergo a classification process based on deep learning. A well-studied dataset of HAM10000 is used in the experiments. The system achieves 81.04% accuracy with EfficientNet model using the proposed fractional derivative based enhancements whereas accuracies are around 77.94% when using original images. In almost all the experiments, the enhanced images improved the accuracy. The results show that the proposed method improves the recognition performance.

人工智能和计算机视觉技术的最新发展使自动检测医学图像中的异常情况成为可能。皮肤病变就是其中的一大类。导致皮肤癌的病变类型也有好几种。黑色素瘤是最致命的皮肤癌之一。其早期诊断至关重要。人工智能可以快速、准确地诊断出这些病症,从而大大有助于治疗。在使用边缘检测的基本图像处理方法时,对皮肤病变内部边界的识别和划分已显示出良好的前景。进一步改进边缘检测是可能的。本文探讨了利用分数微分改进边缘检测在皮肤病变检测中的应用。本文提出了一种基于分数微分滤波器的皮肤病变图像边缘检测框架,可提高恶性黑色素瘤的自动检测率。衍生图像用于增强输入图像。获得的图像随后进行基于深度学习的分类处理。实验中使用了一个经过充分研究的 HAM10000 数据集。该系统使用基于分数导数的增强技术,在 EfficientNet 模型中实现了 81.04% 的准确率,而使用原始图像时的准确率约为 77.94%。在几乎所有实验中,增强图像都提高了准确率。结果表明,建议的方法提高了识别性能。
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引用次数: 0
The value of quantitative shear wave elastography combined with conventional ultrasound in evaluating and guiding fine needle aspiration biopsy of axillary lymph node for early breast cancer: implication for axillary surgical stage. 定量剪切波弹性成像与传统超声相结合在评估和指导早期乳腺癌腋窝淋巴结细针穿刺活检中的价值:对腋窝手术分期的影响。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-30 DOI: 10.1186/s12880-024-01407-0
Xuan Liu, Yi-Ni Huang, Ying-Lan Wu, Xiao-Yao Zhu, Ze-Ming Xie, Jian Li

Objectives: To investigate the value of conventional ultrasonography (US) combined with quantitative shear wave elastography (SWE) in evaluating and identifying target axillary lymph node (TALN) for fine needle aspiration biopsy (FNAB) of patients with early breast cancer.

Materials and methods: A total of 222 patients with 223 ALNs were prospectively recruited from January 2018 to December 2021. All TALNs were evaluated by US, SWE and subsequently underwent FNAB. The diagnostic performances of US, SWE, UEor (either US or SWE was positive) and UEand (both US and SWE were positive), and FNAB guided by the above four methods for evaluating ALN status were assessed using receiver operator characteristic curve (ROC) analyses. Univariate and multivariate logistic regression analyses used to determine the independent predictors of axillary burden.

Results: The area under the ROC curve (AUC) for diagnosing ALNs using conventional US and SWE were 0.69 and 0.66, respectively, with sensitivities of 78.00% and 65.00% and specificities of 60.98% and 66.67%. The combined method, UEor, demonstrated significantly improved sensitivity of 86.00% (p < 0.001 when compared with US and SWE alone). The AUC of the UEor-guided FNAB [0.85 (95% CI, 0.80-0.90)] was significantly higher than that of US-guided FNAB [0.83 (95% CI, 0.78-0.88), p = 0.042], SWE-guided FNAB [0.79 (95% CI, 0.72-0.84), p = 0.001], and UEand-guided FNAB [0.77 (95% CI, 0.71-0.82), p < 0.001]. Multivariate logistic regression showed that FNAB and number of suspicious ALNs were found independent predictors of axillary burden in patients with early breast cancer.

Conclusion: The UEor had superior sensitivity compared to US or SWE alone in ALN diagnosis. The UEor-guided FNAB achieved a lower false-negative rate compared to FNAB guided solely by US or SWE, which may be a promising tool for the preoperative diagnosis of ALNs in early breast cancer, and had the potential implication for the selection of axillary surgical modality.

研究目的研究常规超声造影(US)结合定量剪切波弹性成像(SWE)在评估和识别早期乳腺癌患者细针穿刺活检(FNAB)目标腋窝淋巴结(TALN)中的价值:自2018年1月至2021年12月,共前瞻性招募了222名患者,其中有223个ALN。所有 TALN 均通过 US、SWE 进行评估,随后进行 FNAB。使用接收器操作者特征曲线(ROC)分析评估了US、SWE、UEor(US或SWE均为阳性)和UEand(US和SWE均为阳性)以及上述四种方法指导下的FNAB对评估ALN状态的诊断性能。单变量和多变量逻辑回归分析用于确定腋窝负荷的独立预测因素:使用传统 US 和 SWE 诊断 ALN 的 ROC 曲线下面积(AUC)分别为 0.69 和 0.66,敏感性分别为 78.00% 和 65.00%,特异性分别为 60.98% 和 66.67%。联合方法 UEor 的灵敏度显著提高了 86.00%(与单独的 US 和 SWE 相比,P < 0.001)。UEor 引导的 FNAB 的 AUC [0.85 (95% CI, 0.80-0.90)] 明显高于 US 引导的 FNAB [0.83 (95% CI, 0.78-0.88), p = 0.042]、SWE 引导的 FNAB [0.79 (95% CI, 0.72-0.84), p = 0.001] 和 UEand 引导的 FNAB [0.77 (95% CI, 0.71-0.82), p 结论:在 ALN 诊断中,UEor 的灵敏度优于单纯 US 或 SWE。UEor 引导的 FNAB 与仅由 US 或 SWE 引导的 FNAB 相比,假阴性率更低,这可能是早期乳腺癌 ALN 术前诊断的一种有前途的工具,并对腋窝手术方式的选择有潜在影响。
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引用次数: 0
Prediction model for lateral lymph node metastasis of papillary thyroid carcinoma in children and adolescents based on ultrasound imaging and clinical features: a retrospective study. 基于超声成像和临床特征的儿童和青少年甲状腺乳头状癌侧淋巴结转移预测模型:一项回顾性研究。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-29 DOI: 10.1186/s12880-024-01384-4
Shiyang Lin, Yuan Zhong, Yidi Lin, Guangjian Liu

Background: The presence of lateral lymph node metastases (LNM) in paediatric patients with papillary thyroid cancer (PTC) is an independent risk factor for recurrence. We aimed to identify risk factors and establish a prediction model for lateral LNM before surgery in children and adolescents with PTC.

Methods: We developed a prediction model based on data obtained from 63 minors with PTC between January 2014 and June 2023. We collected and analysed clinical factors, ultrasound (US) features of the primary tumour, and pathology records of the patients. Multivariate logistic regression analysis was used to determine independent predictors and build a prediction model. We evaluated the predictive performance of risk factors and the prediction model using the area under the receiver operating characteristic (ROC) curve. We assessed the clinical usefulness of the predicting model using decision curve analysis.

Results: Among the minors with PTC, 21 had lateral LNM (33.3%). Logistic regression revealed that independent risk factors for lateral LNM were multifocality, tumour size, sex, and age. The area under the ROC curve for multifocality, tumour size, sex, and age was 0.62 (p = 0.049), 0.61 (p = 0.023), 0.66 (p = 0.003), and 0.58 (p = 0.013), respectively. Compared to a single risk factor, the combined predictors had a significantly higher area under the ROC curve (0.842), with a sensitivity and specificity of 71.4% and 81.0%, respectively (cutoff value = 0.524). Decision curve analysis showed that the prediction model was clinically useful, with threshold probabilities between 2% and 99%.

Conclusions: The independent risk factors for lateral LNM in paediatric PTC patients were multifocality and tumour size on US imaging, as well as sex and age. Our model outperformed US imaging and clinical features alone in predicting the status of lateral LNM.

背景:儿童甲状腺乳头状癌(PTC)患者出现侧淋巴结转移(LNM)是导致复发的独立风险因素。我们旨在确定儿童和青少年 PTC 患者手术前出现侧淋巴结转移的风险因素并建立预测模型:方法:我们根据 2014 年 1 月至 2023 年 6 月期间 63 名患有 PTC 的未成年人的数据建立了一个预测模型。我们收集并分析了患者的临床因素、原发肿瘤的超声(US)特征和病理记录。我们采用多变量逻辑回归分析来确定独立的预测因素并建立预测模型。我们使用接收者操作特征曲线下面积(ROC)评估了风险因素和预测模型的预测性能。我们利用决策曲线分析评估了预测模型的临床实用性:在患有 PTC 的未成年人中,21 人患有侧位 LNM(33.3%)。逻辑回归显示,侧位 LNM 的独立风险因素包括多灶性、肿瘤大小、性别和年龄。多灶性、肿瘤大小、性别和年龄的ROC曲线下面积分别为0.62(P = 0.049)、0.61(P = 0.023)、0.66(P = 0.003)和0.58(P = 0.013)。与单一风险因素相比,组合预测因子的 ROC 曲线下面积(0.842)明显更高,灵敏度和特异度分别为 71.4% 和 81.0%(临界值 = 0.524)。决策曲线分析表明,该预测模型对临床有用,阈值概率介于 2% 和 99% 之间:结论:儿科 PTC 患者患侧 LNM 的独立风险因素是 US 成像显示的多灶性和肿瘤大小,以及性别和年龄。我们的模型在预测侧位 LNM 的情况方面优于单纯的 US 成像和临床特征。
{"title":"Prediction model for lateral lymph node metastasis of papillary thyroid carcinoma in children and adolescents based on ultrasound imaging and clinical features: a retrospective study.","authors":"Shiyang Lin, Yuan Zhong, Yidi Lin, Guangjian Liu","doi":"10.1186/s12880-024-01384-4","DOIUrl":"https://doi.org/10.1186/s12880-024-01384-4","url":null,"abstract":"<p><strong>Background: </strong>The presence of lateral lymph node metastases (LNM) in paediatric patients with papillary thyroid cancer (PTC) is an independent risk factor for recurrence. We aimed to identify risk factors and establish a prediction model for lateral LNM before surgery in children and adolescents with PTC.</p><p><strong>Methods: </strong>We developed a prediction model based on data obtained from 63 minors with PTC between January 2014 and June 2023. We collected and analysed clinical factors, ultrasound (US) features of the primary tumour, and pathology records of the patients. Multivariate logistic regression analysis was used to determine independent predictors and build a prediction model. We evaluated the predictive performance of risk factors and the prediction model using the area under the receiver operating characteristic (ROC) curve. We assessed the clinical usefulness of the predicting model using decision curve analysis.</p><p><strong>Results: </strong>Among the minors with PTC, 21 had lateral LNM (33.3%). Logistic regression revealed that independent risk factors for lateral LNM were multifocality, tumour size, sex, and age. The area under the ROC curve for multifocality, tumour size, sex, and age was 0.62 (p = 0.049), 0.61 (p = 0.023), 0.66 (p = 0.003), and 0.58 (p = 0.013), respectively. Compared to a single risk factor, the combined predictors had a significantly higher area under the ROC curve (0.842), with a sensitivity and specificity of 71.4% and 81.0%, respectively (cutoff value = 0.524). Decision curve analysis showed that the prediction model was clinically useful, with threshold probabilities between 2% and 99%.</p><p><strong>Conclusions: </strong>The independent risk factors for lateral LNM in paediatric PTC patients were multifocality and tumour size on US imaging, as well as sex and age. Our model outperformed US imaging and clinical features alone in predicting the status of lateral LNM.</p>","PeriodicalId":9020,"journal":{"name":"BMC Medical Imaging","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11361114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Radiomics diagnostic performance for predicting lymph node metastasis in esophageal cancer: a systematic review and meta-analysis. 更正:预测食管癌淋巴结转移的放射组学诊断性能:系统综述和荟萃分析。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-28 DOI: 10.1186/s12880-024-01411-4
Dong Ma, Teli Zhou, Jing Chen, Jun Chen
{"title":"Correction: Radiomics diagnostic performance for predicting lymph node metastasis in esophageal cancer: a systematic review and meta-analysis.","authors":"Dong Ma, Teli Zhou, Jing Chen, Jun Chen","doi":"10.1186/s12880-024-01411-4","DOIUrl":"10.1186/s12880-024-01411-4","url":null,"abstract":"","PeriodicalId":9020,"journal":{"name":"BMC Medical Imaging","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimized deep CNN for detection and classification of diabetic retinopathy and diabetic macular edema. 用于糖尿病视网膜病变和糖尿病黄斑水肿检测与分类的优化深度 CNN。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-28 DOI: 10.1186/s12880-024-01406-1
V Thanikachalam, K Kabilan, Sudheer Kumar Erramchetty

Diabetic Retinopathy (DR) and Diabetic Macular Edema (DME) are vision related complications prominently found in diabetic patients. The early identification of DR/DME grades facilitates the devising of an appropriate treatment plan, which ultimately prevents the probability of visual impairment in more than 90% of diabetic patients. Thereby, an automatic DR/DME grade detection approach is proposed in this work by utilizing image processing. In this work, the retinal fundus image provided as input is pre-processed using Discrete Wavelet Transform (DWT) with the aim of enhancing its visual quality. The precise detection of DR/DME is supported further with the application of suitable Artificial Neural Network (ANN) based segmentation technique. The segmented images are subsequently subjected to feature extraction using Adaptive Gabor Filter (AGF) and the feature selection using Random Forest (RF) technique. The former has excellent retinal vein recognition capability, while the latter has exceptional generalization capability. The RF approach also assists with the improvement of classification accuracy of Deep Convolutional Neural Network (CNN) classifier. Moreover, Chicken Swarm Algorithm (CSA) is used for further enhancing the classifier performance by optimizing the weights of both convolution and fully connected layer. The entire approach is validated for its accuracy in determination of grades of DR/DME using MATLAB software. The proposed DR/DME grade detection approach displays an excellent accuracy of 97.91%.

糖尿病视网膜病变(DR)和糖尿病黄斑水肿(DME)是糖尿病患者常见的视力相关并发症。早期识别 DR/DME 等级有助于制定适当的治疗方案,最终防止 90% 以上的糖尿病患者出现视力损伤。因此,本研究利用图像处理技术提出了一种 DR/DME 等级自动检测方法。在这项工作中,使用离散小波变换(DWT)对作为输入的视网膜眼底图像进行预处理,以提高其视觉质量。通过应用基于人工神经网络(ANN)的适当分割技术,进一步支持 DR/DME 的精确检测。分割后的图像随后使用自适应 Gabor 滤波器(AGF)进行特征提取,并使用随机森林(RF)技术进行特征选择。前者具有出色的视网膜静脉识别能力,而后者则具有卓越的泛化能力。RF 方法还有助于提高深度卷积神经网络(CNN)分类器的分类准确性。此外,鸡群算法(CSA)通过优化卷积层和全连接层的权重,进一步提高了分类器的性能。使用 MATLAB 软件验证了整个方法在确定 DR/DME 等级方面的准确性。所提出的 DR/DME 等级检测方法的准确率高达 97.91%。
{"title":"Optimized deep CNN for detection and classification of diabetic retinopathy and diabetic macular edema.","authors":"V Thanikachalam, K Kabilan, Sudheer Kumar Erramchetty","doi":"10.1186/s12880-024-01406-1","DOIUrl":"10.1186/s12880-024-01406-1","url":null,"abstract":"<p><p>Diabetic Retinopathy (DR) and Diabetic Macular Edema (DME) are vision related complications prominently found in diabetic patients. The early identification of DR/DME grades facilitates the devising of an appropriate treatment plan, which ultimately prevents the probability of visual impairment in more than 90% of diabetic patients. Thereby, an automatic DR/DME grade detection approach is proposed in this work by utilizing image processing. In this work, the retinal fundus image provided as input is pre-processed using Discrete Wavelet Transform (DWT) with the aim of enhancing its visual quality. The precise detection of DR/DME is supported further with the application of suitable Artificial Neural Network (ANN) based segmentation technique. The segmented images are subsequently subjected to feature extraction using Adaptive Gabor Filter (AGF) and the feature selection using Random Forest (RF) technique. The former has excellent retinal vein recognition capability, while the latter has exceptional generalization capability. The RF approach also assists with the improvement of classification accuracy of Deep Convolutional Neural Network (CNN) classifier. Moreover, Chicken Swarm Algorithm (CSA) is used for further enhancing the classifier performance by optimizing the weights of both convolution and fully connected layer. The entire approach is validated for its accuracy in determination of grades of DR/DME using MATLAB software. The proposed DR/DME grade detection approach displays an excellent accuracy of 97.91%.</p>","PeriodicalId":9020,"journal":{"name":"BMC Medical Imaging","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: YOLO-V5 based deep learning approach for tooth detection and segmentation on pediatric panoramic radiographs in mixed dentition. 更正:基于 YOLO-V5 的深度学习方法,用于混合牙区儿科全景 X 光片上的牙齿检测和分割。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-28 DOI: 10.1186/s12880-024-01410-5
Busra Beser, Tugba Reis, Merve Nur Berber, Edanur Topaloglu, Esra Gungor, Münevver Coruh Kılıc, Sacide Duman, Özer Çelik, Alican Kuran, Ibrahim Sevki Bayrakdar
{"title":"Correction: YOLO-V5 based deep learning approach for tooth detection and segmentation on pediatric panoramic radiographs in mixed dentition.","authors":"Busra Beser, Tugba Reis, Merve Nur Berber, Edanur Topaloglu, Esra Gungor, Münevver Coruh Kılıc, Sacide Duman, Özer Çelik, Alican Kuran, Ibrahim Sevki Bayrakdar","doi":"10.1186/s12880-024-01410-5","DOIUrl":"10.1186/s12880-024-01410-5","url":null,"abstract":"","PeriodicalId":9020,"journal":{"name":"BMC Medical Imaging","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic utility of apparent diffusion coefficient in preoperative assessment of endometrial cancer: are we ready for the 2023 FIGO staging? 表观扩散系数在子宫内膜癌术前评估中的诊断效用:我们为 2023 年 FIGO 分期做好准备了吗?
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-28 DOI: 10.1186/s12880-024-01391-5
Gehad A Saleh, Rasha Abdelrazek, Amany Hassan, Omar Hamdy, Mohammed Salah Ibrahim Tantawy

Background: Although endometrial cancer (EC) is staged surgically, magnetic resonance imaging (MRI) plays a critical role in assessing and selecting the most appropriate treatment planning. We aimed to assess the diagnostic performance of quantitative analysis of diffusion-weighted imaging (DWI) in preoperative assessment of EC.

Methods: Prospective analysis was done for sixty-eight patients with pathology-proven endometrial cancer who underwent MRI and DWI. Apparent diffusion coefficient (ADC) values were measured by two independent radiologists and compared with the postoperative pathological results.

Results: There was excellent inter-observer reliability in measuring ADCmean values. There were statistically significant lower ADCmean values in patients with deep myometrial invasion (MI), cervical stromal invasion (CSI), type II EC, and lympho-vascular space involvement (LVSI) (AUC = 0.717, 0.816, 0.999, and 0.735 respectively) with optimal cut-off values of ≤ 0.84, ≤ 0.84, ≤ 0.78 and ≤ 0.82 mm2/s respectively. Also, there was a statistically significant negative correlation between ADC values and the updated 2023 FIGO stage and tumor grade (strong association), and the 2009 FIGO stage (medium association).

Conclusions: The preoperative ADCmean values of EC were significantly correlated with main prognostic factors including depth of MI, CSI, EC type, grade, nodal involvement, and LVSI.

背景:尽管子宫内膜癌(EC)是通过手术分期的,但磁共振成像(MRI)在评估和选择最合适的治疗方案方面发挥着至关重要的作用。我们旨在评估弥散加权成像(DWI)定量分析在子宫内膜癌术前评估中的诊断性能:方法:我们对 68 例接受核磁共振成像和 DWI 检查的病理证实子宫内膜癌患者进行了前瞻性分析。由两名独立的放射科医生测量表观弥散系数(ADC)值,并与术后病理结果进行比较:结果:在测量 ADC 平均值时,观察者之间的可靠性非常高。子宫肌层深部浸润(MI)、宫颈基质浸润(CSI)、II型EC和淋巴管间隙受累(LVSI)患者的ADC均值明显较低(AUC分别为0.717、0.816、0.999和0.735),最佳临界值分别为≤0.84、≤0.84、≤0.78和≤0.82 mm2/s。此外,ADC值与2023年更新的FIGO分期和肿瘤分级(强相关)以及2009年的FIGO分期(中等相关)之间存在统计学意义上的显著负相关:EC的术前ADC均值与主要预后因素(包括MI深度、CSI、EC类型、分级、结节受累和LVSI)显著相关。
{"title":"Diagnostic utility of apparent diffusion coefficient in preoperative assessment of endometrial cancer: are we ready for the 2023 FIGO staging?","authors":"Gehad A Saleh, Rasha Abdelrazek, Amany Hassan, Omar Hamdy, Mohammed Salah Ibrahim Tantawy","doi":"10.1186/s12880-024-01391-5","DOIUrl":"10.1186/s12880-024-01391-5","url":null,"abstract":"<p><strong>Background: </strong>Although endometrial cancer (EC) is staged surgically, magnetic resonance imaging (MRI) plays a critical role in assessing and selecting the most appropriate treatment planning. We aimed to assess the diagnostic performance of quantitative analysis of diffusion-weighted imaging (DWI) in preoperative assessment of EC.</p><p><strong>Methods: </strong>Prospective analysis was done for sixty-eight patients with pathology-proven endometrial cancer who underwent MRI and DWI. Apparent diffusion coefficient (ADC) values were measured by two independent radiologists and compared with the postoperative pathological results.</p><p><strong>Results: </strong>There was excellent inter-observer reliability in measuring ADCmean values. There were statistically significant lower ADCmean values in patients with deep myometrial invasion (MI), cervical stromal invasion (CSI), type II EC, and lympho-vascular space involvement (LVSI) (AUC = 0.717, 0.816, 0.999, and 0.735 respectively) with optimal cut-off values of ≤ 0.84, ≤ 0.84, ≤ 0.78 and ≤ 0.82 mm<sup>2</sup>/s respectively. Also, there was a statistically significant negative correlation between ADC values and the updated 2023 FIGO stage and tumor grade (strong association), and the 2009 FIGO stage (medium association).</p><p><strong>Conclusions: </strong>The preoperative ADCmean values of EC were significantly correlated with main prognostic factors including depth of MI, CSI, EC type, grade, nodal involvement, and LVSI.</p>","PeriodicalId":9020,"journal":{"name":"BMC Medical Imaging","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic value of combined CT lymphangiography and 99Tcm-DX lymphoscintigraphy in primary chylopericardium. CT淋巴管造影和99Tcm-DX淋巴管造影对原发性乳糜心包炎的诊断价值。
IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-28 DOI: 10.1186/s12880-024-01399-x
Yimeng Zhang, Zhe Wen, Mengke Liu, Xingpeng Li, Mingxia Zhang, Rengui Wang

Objective: To investigate the diagnostic value of combined 99Tcm-DX lymphoscintigraphy and CT lymphangiography (CTL) in primary chylopericardium.

Methods: Fifty-five patients diagnosed with primary chylopericardium clinically were retrospectively analyzed. 99Tcm-DX lymphoscintigraphy and CTL were performed in all patients. Primary chylopericardium was classified into three types, according to the 99Tcm-DX lymphoscintigraphy results. The evaluation indexes of CTL include: (1) abnormal contrast distribution in the neck, (2) abnormal contrast distribution in the chest, (3) dilated thoracic duct was defined as when the widest diameter of thoracic duct was > 3 mm, (4) abnormal contrast distribution in abdominal. CTL characteristics were analyzed between different groups, and P < 0.05 was considered a statistically significant difference.

Results: Primary chylopericardium showed 12 patients with type I, 14 patients with type II, and 22 patients with type III. The incidence of abnormal contrast distribution in the posterior mediastinum was greater in type I than type III (P = 0.003). The incidence of abnormal contrast distribution in the pericardial and aortopulmonary windows, type I was greater than type III (P = 0.008). And the incidence of abnormal distribution of contrast agent in the bilateral cervical or subclavian region was greater in type II than type III (P = 0.002).

Conclusion: The combined application of the 99Tcm-DX lymphoscintigraphy and CTL is of great value for the localized and qualitative diagnosis of primary chylopericardium and explore the pathogenesis of lesions.

目的研究 99Tcm-DX 淋巴管造影和 CT 淋巴管造影(CTL)对原发性乳糜心包炎的诊断价值:方法:对55例经临床诊断为原发性乳糜心包炎的患者进行回顾性分析。对所有患者进行了 99Tcm-DX 淋巴透视和 CTL 检查。根据 99Tcm-DX 淋巴闪烁扫描结果,原发性乳糜心包炎被分为三种类型。CTL 的评价指标包括(1)对比剂在颈部的异常分布;(2)对比剂在胸部的异常分布;(3)胸导管扩张,胸导管最宽直径大于 3 mm;(4)对比剂在腹部的异常分布。对不同组间的 CTL 特征进行分析,并得出 P 结果:原发性乳糜胸患者中,Ⅰ型 12 例,Ⅱ型 14 例,Ⅲ型 22 例。后纵隔对比剂分布异常的发生率 I 型高于 III 型(P = 0.003)。心包窗和主动脉肺窗对比剂分布异常的发生率,I 型高于 III 型(P = 0.008)。对比剂在双侧颈部或锁骨下区域异常分布的发生率,II 型高于 III 型(P = 0.002):99Tcm-DX淋巴管造影和CTL的联合应用对原发性乳糜心包炎的定位和定性诊断以及病变发病机制的探索具有重要价值。
{"title":"Diagnostic value of combined CT lymphangiography and <sup>99</sup>Tc<sup>m</sup>-DX lymphoscintigraphy in primary chylopericardium.","authors":"Yimeng Zhang, Zhe Wen, Mengke Liu, Xingpeng Li, Mingxia Zhang, Rengui Wang","doi":"10.1186/s12880-024-01399-x","DOIUrl":"10.1186/s12880-024-01399-x","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the diagnostic value of combined <sup>99</sup>Tc<sup>m</sup>-DX lymphoscintigraphy and CT lymphangiography (CTL) in primary chylopericardium.</p><p><strong>Methods: </strong>Fifty-five patients diagnosed with primary chylopericardium clinically were retrospectively analyzed. <sup>99</sup>Tc<sup>m</sup>-DX lymphoscintigraphy and CTL were performed in all patients. Primary chylopericardium was classified into three types, according to the <sup>99</sup>Tc<sup>m</sup>-DX lymphoscintigraphy results. The evaluation indexes of CTL include: (1) abnormal contrast distribution in the neck, (2) abnormal contrast distribution in the chest, (3) dilated thoracic duct was defined as when the widest diameter of thoracic duct was > 3 mm, (4) abnormal contrast distribution in abdominal. CTL characteristics were analyzed between different groups, and P < 0.05 was considered a statistically significant difference.</p><p><strong>Results: </strong>Primary chylopericardium showed 12 patients with type I, 14 patients with type II, and 22 patients with type III. The incidence of abnormal contrast distribution in the posterior mediastinum was greater in type I than type III (P = 0.003). The incidence of abnormal contrast distribution in the pericardial and aortopulmonary windows, type I was greater than type III (P = 0.008). And the incidence of abnormal distribution of contrast agent in the bilateral cervical or subclavian region was greater in type II than type III (P = 0.002).</p><p><strong>Conclusion: </strong>The combined application of the <sup>99</sup>Tc<sup>m</sup>-DX lymphoscintigraphy and CTL is of great value for the localized and qualitative diagnosis of primary chylopericardium and explore the pathogenesis of lesions.</p>","PeriodicalId":9020,"journal":{"name":"BMC Medical Imaging","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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BMC Medical Imaging
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