BMC Research Notes最新文献

Objective: The aim of this study was to determine the association between VEGF-A (rs10434, rs3025040) gene polymorphisms and polymorphisms associated with VEGF-A levels (POLR1C: rs4416670, rs6921438, ZFPM2: rs6993770, rs10738760) with hypertension, adiposity (BMI and waist circumference), diabetes and metabolic syndrome in the black South African population.

Results: No polymorphisms were associated with VEGF-A levels or metabolic syndrome in our study. The rs6921438 AA genotype was associated with increased BMI (OR: 5.18, 95% CI [1.42; 18.8], p = 0.013) and waist circumference (OR: 3.26, 95% CI [1.21; 8.75], p = 0.019) compared to participants with the rs6921438 G allele. The rs10434 AG genotype was associated with increased BMI (OR: 1.95, 95% CI [1.00; 3.78], p = 0.049), waist circumference (OR: 2.36, 95% CI [1.21; 4.63], p = 0.012) and a lower risk of diabetes (OR: 0.40, 95% CI [0.17; 0.94], p = 0.036) compared to participants with the two homozygous genotypes. Participants with the rs6993770 AT genotype were less likely to have hypertension (OR: 0.46, 95% CI [0.24; 0.91], p = 0.025) compared to participants with the two homozygous genotypes.

Objective: Conducting health research with adolescents involves navigating complex challenges at both organisational and individual levels. As part of evaluating the EACH-B (Engaging Adolescents with Changing Behaviour) intervention-a school-based randomised controlled trial aimed at improving diet and physical activity in adolescents, we explored researchers' insider experiences of programme implementation. The study investigates real-world implementation challenges and protocol adaptations in the EACH-B trial to provide practical guidance for public health interventions in schools. Applying the Consolidated Framework for Implementation Research (CFIR), data were collected through semi-structured interviews and focus groups with 10 members of the research team.

Results: Researchers identified significant barriers within the 'Inner' settings (internal research processes) and 'Outer' settings (external school environment and policy landscape). Research delivery was hindered by post-pandemic school priorities-specifically academic recovery and mental health support which limited the feasibility of maintaining adolescent engagement and school access. Researcher-led adaptations emerged as a critical, yet often hidden, component of maintaining trial fidelity. The study concludes that reflexive 'insider' perspectives and flexible designs are essential to align research with shifting school priorities. These adaptive strategies provide a blueprint for more resilient and feasible public health interventions.

Introduction: Early pregnancy bleeding (EPB) is considered as an important risk factor for pregnancy loss. Therefore, the rest of the pregnancy is managed cautiously in order to prevent adverse outcome in these patients. Sri Lanka, although a developing country, maternal and fetal health is maintained as a high standard despite limitations. This study is aimed at analysing association of EPB with neonatal outcomes in a low resource setting.

Results: A total of 238 women were included in this retrospective case-control study, of whom 81 (34%) experienced EPB and 157 (66%) served as matched controls. EPB was significantly associated with lower neonatal birth weight (adjusted OR = 2.44, p = 0.017). The odds of preterm delivery were markedly higher among women with EPB (adjusted OR = 14.34, P = 0.001), though the model fit was marginal. No significant associations were found between EPB and, pregnancy induced hypertension, or gestational diabetes mellitus.

Conclusions: This study demonstrates a significant association between EPB and low birth weight and strong but model-wise marginal association with preterm delivery, warranting early identification and close antenatal surveillance of pregnancies complicated by early bleeding, especially in resource-limited settings.

Objective: Our objective was to determine the prevalence of hypertension, overall and by sociodemographic factors, in a large clinical population of 13,873 primarily rural and Indigenous Guatemalan women. The purpose of the research is to present epidemiological findings that can be useful for public health planning and resource allocation.

Results: Overall prevalence of hypertension was 16.3% (95% CI 15.7-17.0%) and age-adjusted prevalence was 16.0% (95% CI 15.3-16.8%) using American Heart Association thresholds of 130 mmHg for systolic blood pressure and 80 mmHg for diastolic blood pressure for classification. Seventy-nine percent of those classified as hypertensive were previously undiagnosed. Hypertension prevalence increased with age and body mass index. Indigenous women and women who spoke Mayan languages both had approximately 20% lower prevalence of hypertension than non-Indigenous and Spanish-speaking women, respectively. In general, hypertension prevalence increased as likelihood of poverty decreased. Among those classified as hypertensive who had a second blood pressure reading available, 53% had elevated blood pressure on the second reading. When thresholds of 140 mmHg and 90 mmHg were used for systolic and diastolic blood pressure, respectively, overall hypertension prevalence was 5.4% (95% CI 5.0-5.8%) and age-adjusted prevalence was 6.0% (95% CI 5.4-6.6%).