Photobiomodulation, photomedicine, and laser surgery最新文献

Objective: The aim of this study was to map and analyze the 20 most cited articles on the use of photobiomodulation (PBM) in different areas of dentistry. Methods: To this end, in June 2024, a search was carried out in the main Web of Science Core Collection for the most cited articles in the following areas: implantology, oral surgery, restorative dentistry, temporomandibular dysfunction and orofacial pain, oral pathology and stomatology, orthodontics, and periodontics. There were no restrictions regarding the year, type of study, and language of publication. From the resulting search, the 20 most cited articles were selected in descending order in each of the cited areas. Information such as authors, number of citations, country of origin of the corresponding author, keywords, study design, year of publication, type of laser used, wavelength, power, and total irradiation time were extracted. Results: The results demonstrated that some characteristics were repeated in the various areas analyzed, such as the fact that Brazil was the country with the largest number of publications; the period between 2012 and 2016 presented the largest number of published articles; the type of laser used in the vast majority of studies was gallium-aluminum arsenide, while the most referenced power and wavelength were 0.25-99 mW and infrared (780-980 nm), respectively. The other bibliometric data varied greatly between areas. Conclusion: Thus, it was observed that PBM is a resource widely used in dentistry and that different protocols are used depending on the specialty, the tissue to be irradiated, and the purpose of the application.

Background: In the eyelid region numerous lesions can develop, spanning from cosmetic imperfections to benign tumors and extending to inflammatory and precancerous lesions. Aim: This study aimed to treat benign periocular lesions with a CO₂ laser and assess the effectiveness, the number of sessions required for resolution, and any potential side effects after the procedure. Materials and Methods: All patients were treated with a nonfractional ablative CO₂ laser. The last evaluation and follow-up visit took place 2 months after the previous operation, with the clinical goal being the complete removal of the lesion. Before the first session and immediately afterward, clinical photographic documentation was completed, and it was done again 2 months after the final session. Patients were rated on a 4-point scale: none, mild, moderate, or severe. Results: A total of 715 patients were registered with different palpebral pathologies, all of whom showed good to excellent results with either no or mild adverse reactions. Conclusions: CO₂ laser is effective and well tolerated to treat periocular lesions, despite the sensitivity of this region.

Background: Working memory (WM) impairments and inattention symptoms are prevalent among adults with attention-deficit/hyperactivity disorder (ADHD). Transcranial photobiomodulation (tPBM) is a promising brain stimulation technique that may enhance cognitive function among adults with ADHD. Objectives: We aimed to explore the effects of tPBM on improving N-back WM and Continuous Performance Test-Identical Pairs (CPT-IP) attention tasks in adults with ADHD, as well as its baseline predictive factors. Methods: Forty-eight adults with ADHD underwent a 7-day tPBM intervention (720 s daily, 1064-nm wavelength, 250 mW/cm² irradiance). Participants completed the N-back (1-back, 2-back, 3-back) WM, and CPT-IP (cpt-2, cpt-3, cpt-4) attention tasks at baseline (T1), after the first (T2), and seventh (T3) interventions, and during four weekly follow-ups (T4-T7). Safety was assessed using the Treatment Emergent Symptom Scale (TESS). Results: The participants showed significant improvements in the 2-back, 3-back, cpt-3, and cpt-4 tasks (all p < 0.001), with peak effect sizes observed at 2-3 weeks post-intervention (Cohen's d = 0.84-1.26). Lower baseline performance predicted greater improvement. The intervention was well-tolerated; three (6.3%) participants reported mild adverse events (TESS scores ≤2), all of which resolved spontaneously. Conclusions: tPBM is effective and well-tolerated for improving WM and attention in adults with ADHD, suggesting its potential use as a non-pharmacological approach for ADHD management.

Objective: This interventional prospective double-blind randomized study investigated the adjunctive inflammation-modulatory effects of photobiomodulation therapy on the periodontal clinical parameters of patients undergoing chemotherapy. Methods: Twenty diagnosed patients with cancer were enrolled in this split-mouth trial. Patients were randomized to implantation with either SRP alone in one quadrant or with five sessions of adjunctive photobiomodulation using a diode laser (density of energy = 2 J/cm² | wavelength = 635 nm | power = 50 mW | spot diameter = 4 mm | exposure time = 5 s | continuous mode) on the other quadrant. The gingiva was radiated buccally and lingually. The laser beam was positioned 3 mm vertically away from the gingival surface and at a right angle to it. Before chemotherapy, all participants were given oral hygiene training and received SRP. In the same session, the patient's baseline clinical measures were taken immediately after the beginning of one chemotherapy session, interventions for each side were started and clinical parameters including gingival index (GI), plaque index (PI), clinical attachment level (CAL), and pain/burning sensation after one chemotherapy session were obtained. Results: Regarding GI and PI, both control and test groups showed favorable results compared with baseline. However, the adjunctive photobiomodulation group outperformed the control group in one chemotherapy session regarding both abovementioned indices (p < 0.05). The photobiomodulation+scaling and root planing (SRP) group showed promising results in terms of gingival discomfort reduction and SRP alone was not effective. No significant effect was observed regarding CAL in both groups (p > 0.05). Conclusion: Based on the results of this study, it can be concluded that photobiomodulation promotes gingival health and reduces PI and GI indices. Photobiomodulation also alleviates pain or burning in the gingiva. Accordingly, adjunctive photobiomodulation therapy may be suggested as a supplementary treatment in patients with cancer.

Objectives: We aimed to compare the effectiveness of oxygen-releasing gel (Blue®M [BM]) alone or associated with photodynamic therapy (PDT), after scaling and root planing (SRP), as adjuvants during the treatment of ligature-induced experimental periodontitis (EP). Materials and Methods: For this aim, Wistar rats underwent EP by placing a cotton ligature around the lower first molar. Ligatures were maintained for 7 days and were subsequently removed. Then, rats were arbitrarily allocated into five groups: EP group-untreated animals; SRP group-SRP followed by the application of saline; BM group-SRP followed by the application of BM gel (0.4 mL); PDT group-SRP followed by photosensitizer and low power laser irradiation (660 nm, 40mW, 60 s); and BM+PDT-SRP followed by BM and later PDT. Results: Treatment with BM, PDT, and BM+PDT groups at both 7 and 30 days resulted in decreased alveolar bone destruction compared with the EP and SRP groups. At 30 days, the PDT and BM+PDT groups enhanced the resolution of inflammation by decreasing the inflammatory infiltrate and increasing alveolar bone neoformation, as evidenced by increased immunostaining of osteocalcin, transforming growth factor beta 1, bone morphogenetic protein-2, and -4. The BM group showed positive effects regarding the inhibition of bone resorption and inflammation but was less effective when compared with the PDT group. Conclusion: In conclusion, our findings demonstrate that PDT significantly reduces alveolar bone loss and enhances connective tissue repair. Treatment with BM gel alone also decreases bone loss and ameliorates the repair of periodontal tissues. However, combining BM with PDT appears to diminish the effects of PDT.

Objective: This study aimed to evaluate the effects of different Er,Cr:YSGG laser disinfection protocols on the bonding performance of bioactive restorative materials to caries-affected dentin (CAD). Background: With the adoption of minimally invasive caries removal techniques, bonding to CAD has become increasingly important. Adhesion challenges caused by CAD can be overcome through the application of effective disinfection methods and the selection of compatible bioactive restorative materials. Methods: A total of 120 human third molars (240 specimens) were prepared, with dentin surfaces exposed under water cooling. After pH-cycling to simulate CAD, specimens were assigned to four disinfection groups: no disinfection (C), 2% chlorhexidine gluconate (CHX), Er,Cr:YSGG laser at 0.5 W (L1), and 1 W (L2). Four restorative materials (n = 12 per group)-G-ænial Achord (a resin composite used as the control group), Equia Forte HT, Beautifil-II Restorative, and Cention Forte-were applied according to manufacturers' instructions. Shear bond strength (SBS) testing was conducted on 192 specimens, while energy-dispersive spectroscopy (EDS) analyzed F, P, and Ca on 48 specimens, and scanning electron microscopy images were obtained from representative specimens. Results: CHX disinfection significantly improved SBS compared to the control group. Among restorative materials, G-ænial Achord showed the highest SBS, while Equia Forte HT demonstrated the lowest (p < 0.05). L1 disinfection combined with G-ænial Achord achieved the highest bond strength, whereas its combination with Equia Forte HT resulted in the lowest (p < 0.05). EDS revealed increased fluoride content on CAD surfaces treated with CHX. Conclusion: Er,Cr:YSGG laser disinfection at 0.5W improved bonding performance for resin composites. Selecting a disinfection protocol based on the restorative material is crucial for optimizing adhesion to CAD.

Purpose: The study's main objective was to assess the efficacy and safety of TANIT, a platform combining functional dermal stimulation with damped bioactive current and mechanical stimulation to reduce adipose tissue (AT) in patients with stage I (SI) or II (SII) lipedema. Methods: A single-center, before-after clinical trial without a control group was conducted on adult women diagnosed with SI or SII lipedema. Patients underwent a treatment protocol for 5 weeks, with weekly sessions. Blood tests, AT thickness, pain threshold, and anthropometric measurements were assessed at baseline and the end of the study, and a satisfaction survey was conducted after treatment. Results: Twenty-three women were enrolled with a mean age of 44.91 (standard deviation 11.58) and a median of 46.00 (Q25 = 36.50, Q75 = 51.50). Seven (30.4%) patients had SI lipedema and 16 (69.6%) had SII. The pain threshold increased in 78.3% of patients at the knee level and 80.0% at the ankle level. Lower limb volume decreased in 78.3% of patients. AT thickness decreased in all treated areas, with a mean decrease of 26.1% at the ankles, 14.5% at the knees, and 17.4% at the trochanter level. Patients reported high satisfaction with the results obtained after the treatment sessions, and no unexpected adverse effects were found. Conclusions: The TANIT platform provided an effective and safe conservative treatment option for patients with S and SII lipedema, reducing leg volume, AT thickness, and pain. However, additional randomized clinical trials and standardized assessment tools would be necessary.

Background and Objective: Breast cancer (BC) is one of the most common cancers among women, with a high potential for metastasis. The epithelial-mesenchymal transition (EMT) is crucial in the invasion and metastasis of cancer cells. This research was designed to examine the efficacy of photobiomodulation therapy in combination with celecoxib in inhibiting the EMT process. We also analyzed the changes in the expression of E-cadherin, N-cadherin, and α-SMA genes in BC cell lines MCF-7 and MDA-MB-231. Material and Methods: In this study, the IC₅₀ of celecoxib was first determined using the 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide assay for both cell lines. The cells were then treated with celecoxib, laser irradiation, and their combination. A migration assay was performed to evaluate the cell migration. Real-time polymerase chain reaction also assessed the changes in the expression of the abovementioned genes. Results: A combination of celecoxib and laser therapy significantly reduced the migration of cancer cells. Additionally, the potentiated effect of the combined therapy altered the expression levels of the aforementioned genes, indicating the potential role of the combination treatment in regulating EMT. Conclusions: Our research discloses that combining laser therapy with celecoxib could serve as an effective therapeutic approach to inhibit BC invasion and metastasis by targeting the EMT process and decelerating disease progression. Further investigations are essential to validate these results in clinical environments.

Objective: This study was conducted to investigate whether the addition of photobiomodulation therapy (PBMT) to pelvic floor exercises (PFEs) is more effective in treating postpartum coccydynia compared with either modality alone. Background: Postpartum coccydynia is a widespread condition that significantly affects the quality of life. Inflammation as a response to childbirth trauma and weakening of the muscles and ligaments attached to the coccyx are presumed causes of postpartum coccydynia. Finding effective modalities to manage this condition will help the quality of life for most women. Methods: Sixty women aged 25-35 years with postpartum coccydynia ≥6 weeks were randomly allocated to Group A (PBMT + hot pack + PFEs), Group B (PBMT + hot pack), and Group C (placebo PBMT + hot pack + PFEs). All groups received 12 sessions over 4 weeks of hot packs plus their allocated active treatment (PBMT and/or PFEs). Outcomes were pain intensity (visual analog scale), lumbar flexion range of motion (ROM) (modified Schober test), and self-reported disability (Oswestry Disability Index). The assessors were blinded to group allocation. Results: All the measured outcomes showed significant differences (p < 0.001), with the superiority of Group A over the other groups (p < 0.001). Within groups, all groups showed statistically significant improvement from baseline across outcomes (p < 0.05). Conclusions: Adding PBMT to PFEs is recommended in the management of postpartum coccydynia as this combination resulted in greater reductions in pain and disability, along with improved lumbar flexion ROM.