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Preparation and physico-chemical properties of lanthanide(III) complexes with 2-((E)- (tert- butylimino)methyl)-6-methoxyphenol 镧系(III)与2-((E)-(叔丁基)甲基)-6-甲氧基苯酚配合物的制备及理化性质
4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.8
Kwakhanya Mkwakwi, Eric Hosten, Richard Betz, Abubak’r Abrahams, Tatenda Madanhire
ABSTRACT. The reactions of lanthanide nitrates with 2-((E)-(tert-butylimino)methyl)-6-methoxyphenol (HL1) have yielded five complexes that are described by the formulae [Ce(HL1)2(NO3)3]∙MeOH and [Ln(HL1)2(NO3)3] (Ln = Nd(III), Gd(III), Ho(III) and Er(III)) and were characterized using physico-chemical techniques including single-crystal X-ray diffraction spectroscopy. The cerium complex crystallized in a triclinic P-1 space group, while the rest of the complexes crystallized in the monoclinic P21/c space group. All the complexes are ten-coordinate, adopting a tetradecahedron geometry with two HL1 molecules coordinated through the phenolic and methoxy oxygen atoms. The coordination sphere is completed by six oxygen atoms from three bidentately coordinated nitrate ligands. Electronic data reveals that only the neodymium, holmium and erbium complexes exhibit weak f-f transitions in the visible region. KEY WORDS: Preparation, Physico-chemical properties, Lanthanide, Schiff base complexes, Crystal structure, Geometry Bull. Chem. Soc. Ethiop. 2023, 37(6), 1397-1410. DOI: https://dx.doi.org/10.4314/bcse.v37i6.8
摘要硝酸镧系与2-((E)-(叔丁基苯基)甲基)-6-甲氧基苯酚(HL1)反应生成了5种配合物,分子式为[Ce(HL1)2(NO3)3]∙MeOH和[Ln(HL1)2(NO3)3] (Ln = Nd(III), Gd(III), Ho(III)和Er(III)),并利用包括单晶x射线衍射光谱在内的物理化学技术对其进行了表征。铈配合物在三斜P-1空间群中结晶,其余配合物在单斜P21/c空间群中结晶。所有的配合物都是十配位的,采用四面体的几何结构,两个HL1分子通过酚和甲氧基氧原子配位。配位球由三个双齿配位的硝酸盐配体中的六个氧原子组成。电子数据显示,只有钕、钬和铒配合物在可见光区表现出弱的f-f跃迁。 关键词:制备,理化性质,镧系元素,席夫碱配合物,晶体结构,几何;公牛。化学。Soc。中国生物医学工程学报,2017,37(6),1397-1410。DOI: https://dx.doi.org/10.4314/bcse.v37i6.8
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 KEY WORDS: Preparation, Physico-chemical properties, Lanthanide, Schiff base complexes, Crystal structure, Geometry
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引用次数: 0
Synthesis, spectral characterization, and biological activities of novel palladium(II) and platinum(II) complexes of active Schiff base ligands 新型活性席夫碱配体钯(II)和铂(II)配合物的合成、光谱表征和生物活性
4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.7
Jaswant Raj, Akshita Jain, Naveen Sharma, Anita Kumari, Nighat Fahmi
ABSTRACT. A new series of palladium(II) and platinum(II) Schiff base complexes have been synthesized by the interaction of ligands N-(2-fluoro benzylidene)isonicotinohydrazone (L1H) and N-(2-fluorophenylethanone) isonicotinohydrazone (L2H) with PdCl2 and PtCl2. Elemental investigations, melting point determinations, molecular weight determinations, IR, 1H NMR, and UV-Visible spectral studies were used to describe the structure and bonding pattern of ligands and their metal complexes. These analyses revealed that the ligands coordinate with the metal ions in a monobasic bidentate manner and that the complexes have a square planar geometry. The antimicrobial activities of both the ligands and their palladium(II) and platinum(II) complexes have been tested against various bacterial and fungal strains and showed considerable antifungal and antibacterial characteristics. The in vitro cytotoxic activity of [Pt(L2H)]Cl2 complex was assessed by examining its potential to inhibit cell proliferation against the human HeLa cell line(cervical cancer cell line) using MTT assay and the antioxidant activity of [Pt(L1H)2]Cl2 compound was performed against DPPH. The results showed a dose-dependent cytotoxic and radical scavenging activity thus pointing towards the biological significance of Pt(II) complexes. KEY WORDS: Schiff base ligands, Antimicrobial activity, Scavenging activity, Cytotoxic Bull. Chem. Soc. Ethiop. 2023, 37(6), 1383-1396. DOI: https://dx.doi.org/10.4314/bcse.v37i6.7
摘要通过配体N-(2-氟苄基)异烟碱腙(L1H)和N-(2-氟苯乙酮)异烟碱腙(L2H)与PdCl2和PtCl2的相互作用,合成了一系列新的钯(II)和铂(II)希夫碱配合物。元素研究、熔点测定、分子量测定、IR、1H NMR和uv -可见光谱研究被用来描述配体及其金属配合物的结构和键合模式。这些分析表明,配体与金属离子以单碱双齿方式配位,配合物具有方形平面几何形状。该配体及其钯(II)和铂(II)配合物对多种细菌和真菌的抑菌活性进行了测试,并显示出相当的抗真菌和抗菌特性。采用MTT法检测[Pt(L2H)]Cl2复合物对人HeLa细胞系(宫颈癌细胞系)的细胞增殖抑制作用,并测定[Pt(L2H)]Cl2复合物对DPPH的抗氧化活性。结果显示,Pt(II)复合物具有剂量依赖性的细胞毒性和自由基清除活性,从而指出Pt(II)复合物的生物学意义。关键词:希夫碱配体;抗菌活性;清除活性;公牛。化学。Soc。中国生物医学工程学报,2017,37(6),1383-1396。DOI: https://dx.doi.org/10.4314/bcse.v37i6.7
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 KEY WORDS: Schiff base ligands, Antimicrobial activity, Scavenging activity, Cytotoxic
 Bull. Chem. Soc. Ethiop. 2023, 37(6), 1383-1396. DOI: https://dx.doi.org/10.4314/bcse.v37i6.7","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication of novel PN-heterojunction CuS/TiO2 nanocomposite for the photocatalytic degradation of rhodamine B dye under visible light irradiation 新型pn -异质结cu /TiO2纳米复合材料在可见光下光催化降解罗丹明B染料的制备
4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.19
Zahid Mahmood, Waheed Aslam, Muhammad Bilal, Khalid Javed
ABSTRACT. In the current study, a novel visible light-active photocatalyst CuS/TiO2 nanocomposite was synthesized by a template-free hydrothermal method. Fourier transform infrared spectroscopy (FTIR) confirmed the formation of synthesized nanocomposites and the structural characteristics of synthesized nanoparticles were characterized and confirmed by the X-ray diffraction (XRD) technique. The morphology and particle size of synthesized nanocomposites were measured by a field emission scanning electron microscope (FESEM), which revealed an average particle size of around 30 nm. The optimized efficiency of the fabricated photocatalyst was assessed for the photodegradation of rhodamine B (RhB) dye. It was observed that the photodegradation efficiency of CuS/TiO2-Y composites having a molar ratio of 1:1 for RhB was found to be 89.54% under visible light irradiation. KEY WORDS: CuS/TiO2 nanocomposite, Heterojunction structure, Rhodamine B, Photodegradation, Visible light irradiation Bull. Chem. Soc. Ethiop. 2023, 37(6), 1553-1564. DOI: https://dx.doi.org/10.4314/bcse.v37i6.19
摘要本研究采用无模板水热法制备了一种新型可见光活性光催化剂cu /TiO2纳米复合材料。傅里叶变换红外光谱(FTIR)证实了合成的纳米复合材料的形成,并用x射线衍射(XRD)技术对合成的纳米颗粒的结构特征进行了表征和证实。利用场发射扫描电镜(FESEM)测量了合成的纳米复合材料的形貌和粒径,发现其平均粒径约为30 nm。考察了优化后的光催化剂对罗丹明B染料的光降解效率。结果表明,在可见光照射下,物质摩尔比为1:1的cu /TiO2-Y复合材料对RhB的光降解效率为89.54%。 关键词:cu /TiO2纳米复合材料,异质结结构,罗丹明B,光降解,可见光照射;公牛。化学。Soc。中国生物医学工程学报,2016,37(6):1553-1564。DOI: https://dx.doi.org/10.4314/bcse.v37i6.19
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 KEY WORDS: CuS/TiO2 nanocomposite, Heterojunction structure, Rhodamine B, Photodegradation, Visible light irradiation
 Bull. Chem. Soc. Ethiop. 2023, 37(6), 1553-1564. DOI: https://dx.doi.org/10.4314/bcse.v37i6.19","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Fluoride content of common legume beans consumed in Ethiopia 埃塞俄比亚食用的普通豆豆的氟化物含量
4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.3
Kalkidan Lemma, Bhagwan Singh Chandravanshi, Yonas Chebude
ABSTRACT. The most widely used legume beans food in Ethiopia are fava beans (Vicia faba), green gram (Vigna radiata), white lupin (Lupinus albus), and three types of kidney beans (Phaseolus vulgaris). These legume crops are grown in various regions of Ethiopia and can absorb significant amounts of fluoride from air, water, and soil. This study examined the fluoride content of legume beans collected from four different regions of Ethiopia by ion selective electrode potentiometry. Fluoride concentrations in this study were found to range from 1.9 to 22.8 mg/kg. Fava bean sample from Asella was found to contain higher fluoride (22.8 mg/kg) than in the fava beans from other sites and other beans from any site. Fluoride levels (13.0 mg/kg) in kidney bean from Migira was in the middle of the range while the fluoride levels (2.5 mg/kg) in the white lupin and green gram (1.9 mg/kg) were found in the lower end of the range. This study indicates that daily consumption of 100 g of fava and kidney beans may results in health problem while that of green gram and white lupin are safe for human health (will not exceed 3 mg/day set by Food and Nutrition Board of USA). KEY WORDS: Fava bean, Green gram, Kidney beans, White lupin, Food, Fluoride Bull. Chem. Soc. Ethiop. 2023, 37(6), 1325-1336. DOI: https://dx.doi.org/10.4314/bcse.v37i6.3
摘要在埃塞俄比亚最广泛使用的豆类食品是蚕豆(Vicia faba),绿克(Vigna radiata),白罗苹(Lupinus albus)和三种芸豆(Phaseolus vulgaris)。这些豆科作物生长在埃塞俄比亚的各个地区,可以从空气、水和土壤中吸收大量的氟化物。本研究采用离子选择电极电位法检测了从埃塞俄比亚四个不同地区收集的豆豆的氟化物含量。本研究发现氟化物浓度在1.9至22.8毫克/公斤之间。发现来自Asella的蚕豆样品的氟化物含量(22.8毫克/公斤)高于来自其他地点的蚕豆和来自任何地点的其他蚕豆。米吉拉芸豆的氟化物含量(13.0毫克/公斤)处于该范围的中间,而白豆和绿豆的氟化物含量(2.5毫克/公斤)和绿豆的氟化物含量(1.9毫克/公斤)处于该范围的低端。本研究表明,每天食用100克蚕豆和芸豆可能会导致健康问题,而食用绿克和白豆对人体健康是安全的(不超过美国食品和营养委员会规定的每天3毫克)。 关键词:蚕豆、绿豆、芸豆、白豆、食品、氟化物;公牛。化学。Soc。中国生物医学工程学报,2017,37(6),1325-1336。DOI: https://dx.doi.org/10.4314/bcse.v37i6.3
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 KEY WORDS: Fava bean, Green gram, Kidney beans, White lupin, Food, Fluoride
 Bull. Chem. Soc. Ethiop. 2023, 37(6), 1325-1336. DOI: https://dx.doi.org/10.4314/bcse.v37i6.3","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of biologically active xanthene, chromene, thiazole, thiophene, pyrazole, and isoxazole derivatives from camphor 以樟脑为原料合成具有生物活性的杂蒽、铬烯、噻唑、噻吩、吡唑和异恶唑衍生物
4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.18
Ensaf Sultan Alwan, Rafat Milad Mohareb
ABSTRACT. Xanthene, chromene, thiazole, thiophene, pyrazole, and isoxazole derivatives were synthesized from camphor-D monoterpene using multi-component reactions. Camphor has anti-bacterial, anti-fungal and anti-inflammatory properties. It is also used to mitigate pain, treat skin diseases, and improve respiratory functions. In this research, we focus on the effectiveness of the produced compounds from the biologically active camphor. The produced compounds were formed according to various reactions such as a Knoevenagel condensation, Michael adduct, Gewald reaction, a nucleophilic attack, substitution, addition, elimination and cyclization reactions. Furthermore, the novel produced compounds have been tested towards the six cancer cell lines namely A549, MKN-45, U87MG, HT-29, H460 and SMMC-772. Compounds 5, 11, 15b, 16, 25b and 27b displayed the highest inhibitions compounds toward the mentioned cancer cell lines. In addition, compounds 3, 13, 15a, 22a, 27a and 28 showed moderate inhibitory effects against the cancer cell lines. KEY WORDS: Camphor, Xanthenes, Pyrimidine, Heterocyclic, Anti-cancer Bull. Chem. Soc. Ethiop. 2023, 37(6), 1539-1552. DOI: https://dx.doi.org/10.4314/bcse.v37i6.18
摘要以樟脑- d单萜为原料,采用多组分反应合成了杂蒽、铬烯、噻唑、噻吩、吡唑和异恶唑衍生物。樟脑具有抗菌、抗真菌和抗炎的特性。它也被用来减轻疼痛,治疗皮肤病,改善呼吸功能。在本研究中,我们重点研究了从生物活性樟脑中提取的化合物的有效性。所生成的化合物是根据各种反应形成的,如Knoevenagel缩合、Michael加合、Gewald反应、亲核攻击、取代、加成、消除和环化反应。此外,新合成的化合物已对A549、MKN-45、U87MG、HT-29、H460和SMMC-772 6种癌细胞系进行了测试。化合物5、11、15b、16、25b和27b对上述肿瘤细胞系的抑制作用最强。此外,化合物3、13、15a、22a、27a和28对癌细胞具有中等抑制作用。 关键词:樟脑,杂蒽,嘧啶,杂环,抗癌;公牛。化学。Soc。中国生物医学工程学报,2016,37(6):1539-1552。DOI: https://dx.doi.org/10.4314/bcse.v37i6.18
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 KEY WORDS: Camphor, Xanthenes, Pyrimidine, Heterocyclic, Anti-cancer
 Bull. Chem. Soc. Ethiop. 2023, 37(6), 1539-1552. DOI: https://dx.doi.org/10.4314/bcse.v37i6.18","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemical analysis and biological activities of two oil-bearing extracts from fresh Pistacia lentiscus 两种新鲜黄连木含油提取物的植物化学分析及生物活性研究
4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.15
Omayma Abidi, Zaineb Abdelkafi-Koubaa, Nadia Fares-Zagrouba, Salem Elkahoui, Lamjed Toumi, Lamjed Marzouki, Ouajdi Souilem
ABSTRACT. This study aims to investigate the anti-cancer, antimicrobial and antioxidant activities of Pistacia lentiscus L. (P. lentiscus) extracts, as well as their phyto-chemical profile. The GC-MS crude chemical profile provided new chemotypes of fixed oil (FO) and essential oil (EO) extracts. Secondary metabolites screened high levels of polyphenols and condensed tannins in EO, while FO had the highest flavonoids content. A potent anti-proliferative activity of both extracts was shown on two human breast cancer cells (EO-IC50 = 5.2 mg/mL MDA-MB-231 cells). The antimicrobial activity showed that only EO was active against six multidrug resistant bacteria (inhibition zone 20-8 mm) and two fungi strains (inhibition zone 3-4 mm). Also, the highest in vitro antioxidant free-radical scavenging ability was in the case of EO (125.5 μg/mL). In vivo P. lentiscus EO provided corrective effect vs the tamoxifen (Txf) induced oxidative damage in liver and kidney in C57BL/6 in female mouse. These findings confirm that EO inhibits cell proliferation, induces bacterial death and has a potential antioxidant activity. KEY WORDS: Phytotherapy, Pistacia lentiscus, Antioxidant, Antimicrobial activity, Breast cancer Bull. Chem. Soc. Ethiop. 2023, 37(6), 1487-1501. DOI: https://dx.doi.org/10.4314/bcse.v37i6.15
摘要本研究旨在研究扁豆皮(Pistacia lentiscus L., P. lentiscus)提取物的抗癌、抑菌和抗氧化活性,以及其植物化学特征。GC-MS粗化学谱提供了固定油(FO)和精油(EO)提取物的新化学类型。次生代谢物筛选出高含量的多酚和浓缩单宁,而鱼油中黄酮类化合物含量最高。两种提取物对两种人乳腺癌细胞(EO-IC50 = 5.2 mg/mL MDA-MB-231细胞)均有较强的抗增殖活性。抑菌活性表明,只有EO对6株多药耐药菌(抑制区20 ~ 8 mm)和2株真菌(抑制区3 ~ 4 mm)有抑菌活性。体外抗氧化自由基清除能力最高的是EO (125.5 μg/mL)。在体内,对雌性小鼠C57BL/6 (t57bl /6)所致的肝、肾氧化损伤有一定的纠正作用。这些发现证实了EO抑制细胞增殖,诱导细菌死亡,并具有潜在的抗氧化活性。 关键词:植物疗法;黄连木;抗氧化;公牛。化学。Soc。中国生物医学工程学报,2016,37(6),1487-1501。DOI: https://dx.doi.org/10.4314/bcse.v37i6.15
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 KEY WORDS: Phytotherapy, Pistacia lentiscus, Antioxidant, Antimicrobial activity, Breast cancer
 Bull. Chem. Soc. Ethiop. 2023, 37(6), 1487-1501. DOI: https://dx.doi.org/10.4314/bcse.v37i6.15","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-component synthesis of pyrazolo[1,5-a]quinazoline, thiazole and thiophene derivatives as cytotoxic agents 吡唑啉[1,5-a]、喹唑啉、噻唑和噻吩衍生物的多组分合成
4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.17
Rafat M. Mohareb, Maher H. E. Helal, Amany E. Mayhoub, Amira E. M. Abdallah
ABSTRACT. This study demonstrated the synthesis of a number of pyrazolo[1,5-a]quinazoline derivatives about 24 products based on the starting material 4-(2-phenylhydrazono)-4H-pyrazol-3-amine derivatives 1a-f. Moreover, other ring systems including thiophene, pyrazole, thiazole and pyran (16 compounds) were prepared based on another starting compounds 2-(furan-2-ylmethylene)cyclohexane-1,3-dione 10 and 5,5-dimethyl-3-phenyl-2-thioxo-2,3,5,6-tetrahydrobenzo[d]thiazol-7(4H)-one 18. The multi-component reaction was used to prepare all the previous compounds. The structures of all the synthesised compounds were confirmed by the analytical and spectral data. Some selected compounds were chosen to test their anticancer activity against six cancer cell lines, namely A549, HT-29, MKN-45, U87MG, SMMC-7721 and, H460 utilizing foretinib as the positive control and the standard MTT assay in vitro. Toward the tested cell lines, nine compounds were the most cytotoxic compounds. The results obtained revealed that the synthesized compounds are good cytotoxic agents and of great impact for future work. KEY WORDS: Multi-component reactions, Pyrazolo[1,5-a]quinazoline, Thiophene, Thiazole, Cytotoxicity Bull. Chem. Soc. Ethiop. 2023, 37(6), 1521-1538. DOI: https://dx.doi.org/10.4314/bcse.v37i6.17
摘要本研究以4-(2-苯基肼)- 4h -吡唑-3-胺衍生物1a-f为原料,合成了约24个吡唑啉[1,5-a]喹唑啉衍生物。此外,以2-(呋喃-2-基亚甲基)环己烷-1,3-二酮10和5,5-二甲基-3-苯基-2-硫氧基-2,3,5,6-四氢苯并[d]噻唑-7(4H)- 1 18为起始化合物制备了包括噻吩、吡唑、噻唑和吡喃(16个化合物)在内的其他环体系。上述化合物均采用多组分反应制得。所有合成化合物的结构都通过分析和光谱数据得到证实。以福替尼为阳性对照,采用标准MTT法对6种肿瘤细胞系A549、HT-29、MKN-45、U87MG、SMMC-7721和H460进行体外抑癌活性试验。对被试细胞系,9种化合物的细胞毒性最强。结果表明,合成的化合物是良好的细胞毒性药物,对今后的研究具有重要意义。关键词:多组分反应,吡唑啉[1,5-a]喹唑啉,噻吩,噻唑,细胞毒性;公牛。化学。Soc。中国生物医学工程学报,2016,37(6):1521-1538。DOI: https://dx.doi.org/10.4314/bcse.v37i6.17
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 KEY WORDS: Multi-component reactions, Pyrazolo[1,5-a]quinazoline, Thiophene, Thiazole, Cytotoxicity
 Bull. Chem. Soc. Ethiop. 2023, 37(6), 1521-1538. DOI: https://dx.doi.org/10.4314/bcse.v37i6.17","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation of voltammetric sensors for taurine detection from Cu(II)-loaded carbon materials 负载Cu(II)碳材料制备牛磺酸检测伏安传感器
4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.20
Fatma Bilge Emre
ABSTRACT. In this study, for the detection of taurine in philological fluids, modified electrodes were prepared from glassy carbon electrodes with MWCNT (multi-wall carbon nanotube) + Cu(NO3)2 + carbon-based material. A carbon-based material was obtained by carbonization of Pinus sylvestris branch needles (CPS). Cu(NO3)2 and MWCNT structure (Cu(NO3)2/MWCNT) were added to the carbon-based material and the obtained mixture was used in the modification of the glassy carbon electrode surface. The surface morphology and structure of the prepared electrodes were characterized by electron microscopy scanning (SEM) and atomic force microscopy (AFM). Taurine detection with a modified electrode was made by cyclic voltammetry (CV) in 0.1 M KCl (vs. Ag/AgCl). The calibration curve of the modified electrode for taurine in the 10-150 µM range showed a linear response, and R2 value was 0.976. Limit of detection (LOD) and limit of quantification (LOQ) of the modified electrode were found 19 µM and 9.75 µM, respectively. The application of the electrode as a chemical sensor was carried out with commercially available energy drink samples. Satisfactory results have been obtained from the samples. The sensor can be used for routine taurine analysis. This electrode can quickly determine the amount of taurine in real samples with 90% accuracy in two minutes. KEY WORDS: Taurine detection, Modified electrode, MWCNT, Sensor, Cyclic voltammetry Bull. Chem. Soc. Ethiop. 2023, 37(6), 1565-1576. DOI: https://dx.doi.org/10.4314/bcse.v37i6.20
摘要本研究以MWCNT(多壁碳纳米管)+ Cu(NO3)2 +碳基材料为电极,制备了修饰电极,用于检测语言流体中的牛磺酸。以松针为原料,进行炭化制备碳基材料。在碳基材料中加入Cu(NO3)2和MWCNT结构(Cu(NO3)2/MWCNT),并将所得混合物用于玻碳电极表面改性。利用电子显微镜(SEM)和原子力显微镜(AFM)对制备电极的表面形貌和结构进行了表征。采用0.1 M KCl (vs. Ag/AgCl)循环伏安法(CV)对改进电极进行牛磺酸检测。改良电极对牛磺酸在10 ~ 150µM范围内的校准曲线呈线性响应,R2值为0.976。修饰电极的检测限(LOD)和定量限(LOQ)分别为19µM和9.75µM。将该电极作为化学传感器应用于市售能量饮料样品中。样品得到了满意的结果。该传感器可用于常规牛磺酸分析。该电极可在两分钟内快速测定实际样品中牛磺酸的含量,准确度达90%。 关键词:牛磺酸检测,修饰电极,MWCNT,传感器,循环伏安法;公牛。化学。Soc。中国生物医学工程学报,2016,37(6):1565-1576。DOI: https://dx.doi.org/10.4314/bcse.v37i6.20
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 KEY WORDS: Taurine detection, Modified electrode, MWCNT, Sensor, Cyclic voltammetry
 Bull. Chem. Soc. Ethiop. 2023, 37(6), 1565-1576. DOI: https://dx.doi.org/10.4314/bcse.v37i6.20","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"184 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of phosphorus by phosphorus molybdenum blue spectrophotometry by bismuth antimony sensitization 铋锑敏化磷钼蓝分光光度法测定磷
4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.1
Qing-Zhou Zhai
ABSTRACT. The determination of phosphorus in rain water is of great significance. In this paper the optimum conditions of phosphorus molybdenum blue spectrophotometric method for the determination of phosphorus content were obtained. At the maximum absorption wavelength 690 nm, the apparent molar absorptivity is ε690 nm = 1.44 × 104 L·mol-1·cm-1. Beer’s law is followed over the range of 0.02-1.8 μg·mL-1 for phosphorus(V) content. Bismuth(III) and antimony(III) as the sensitizer has a sensitization effect on the phosphomolybdenum blue photometry. The addition of both simultaneously increases the sensitivity by 71.3%. The present method has been used for the determination of phosphorus in water samples. The recovery of method is between 99.20 - 100.1% and the relative standard deviation is between 1.31-1.33% for eleven determination. The results determined by the present method were in agreement with those of atomic absorption spectrometry. This method can avoid the harm of organic reagent to human body and to environmental pollution without organic solvent extraction. This method does not need heating with room temperature color development. Compared with other methods, it has the advantages that the operation is simple, fast and the sensitivity is high. Bull. Chem. Soc. Ethiop. 2023, 37(6), 1307-1313. DOI: https://dx.doi.org/10.4314/bcse.v37i6.1
摘要雨水中磷的测定具有重要意义。本文确定了磷钼蓝分光光度法测定磷含量的最佳条件。在最大吸收波长690 nm处,表观摩尔吸收率ε690 nm = 1.44 × 104 L·mol-1·cm-1。磷(V)含量在0.02 ~ 1.8 μg·mL-1范围内符合Beer定律。铋(III)和锑(III)作为增感剂对磷钼蓝光度法有增感作用。两者同时加入可使灵敏度提高71.3%。本方法已用于水样中磷的测定。方法的回收率为99.20 ~ 100.1%,相对标准偏差为1.31 ~ 1.33%。本方法测定的结果与原子吸收光谱法测定的结果一致。该方法既避免了有机试剂对人体的危害,又避免了有机溶剂萃取对环境的污染。这种方法不需要室温显色加热。与其他方法相比,具有操作简单、快速、灵敏度高的优点。 公牛。化学。Soc。中国生物医学工程学报,2017,37(6),1307-1313。& # x0D;DOI: https://dx.doi.org/10.4314/bcse.v37i6.1
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 Bull. Chem. Soc. Ethiop. 2023, 37(6), 1307-1313. 
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引用次数: 0
Exploring novel coral reef-like RuO2 oxides: Synthesis and physicochemical characterizations of gatifloxacin-based Ru(III) complexes 探索新型珊瑚礁状RuO2氧化物:基于加替沙星的Ru(III)配合物的合成和理化表征
4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.12
Khaled Althubeiti
ABSTRACT. Two mixed-ligand complexes of Ru(III) ions were synthesized and used to generate nanostructured RuO2 oxide. Complex A contains gatifloxacin (L1), the amino acid glycine (L2), and Ru(III) ions in a 1:1:1 ratio. Complex B contains gatifloxacin (L1), the amino acid alanine (L3), and Ru(III) ions in a 1:1:1 ratio. The synthesized complexes were characterized using UV-Visible and IR spectroscopies, molar conductance, elemental analyses, thermogravimetry, XRD, and SEM-EDX techniques. In both complexes, the L1 ligand acts as a bidentate and uses the nitrogen atoms of the piperazine ring to capture the Ru(III) ions, while the L2 and L3 ligands capture the Ru(III) ions using their oxygen atom of the carboxylate group and the nitrogen atom of the amino group. The atmosphere around the Ru(III) ion is octahedral, and the complexes were formulated as [RuL1L2(H2O)2]Cl2 and [RuL1L3(H2O)2]Cl2 for Complex A and Complex B, respectively. Complex A was directly decomposed in air at 600 °C for 3 h to produce RuO2 oxide (Oxide A), and complex B was decomposed under the same conditions to produce RuO2 oxide (Oxide B). Morphologically, oxide A and oxide B have a coral reef-like texture with large holes and cavities. KEY WORDS: Gatifloxacin, Ru(III) ion, Glycine, Alanine, Morphology, RuO2 oxide Bull. Chem. Soc. Ethiop. 2023, 37(6), 1443-1457. DOI: https://dx.doi.org/10.4314/bcse.v37i6.12
摘要合成了两种钌(III)离子的混合配体配合物,并用于制备纳米结构的氧化钌。配合物A含有加替沙星(L1)、甘氨酸(L2)和Ru(III)离子,比例为1:1:1。配合物B含有加替沙星(L1)、氨基酸丙氨酸(L3)和Ru(III)离子,比例为1:1:1。利用紫外-可见和红外光谱、摩尔电导、元素分析、热重、XRD和SEM-EDX技术对合成的配合物进行了表征。在这两个配合物中,L1配体作为双齿体,利用哌嗪环的氮原子捕获Ru(III)离子,而L2和L3配体利用羧酸基的氧原子和氨基的氮原子捕获Ru(III)离子。Ru(III)离子周围的气氛为八面体,配合物A和配合物B分别为[RuL1L2(H2O)2]Cl2和[RuL1L3(H2O)2]Cl2。配合物A在空气中600℃下直接分解3 h生成氧化若o2(氧化物A),配合物B在相同条件下分解生成氧化若o2(氧化物B)。从形貌上看,氧化物A和氧化物B具有类似珊瑚礁的结构,具有较大的孔洞和空腔。 关键词:加替沙星,钌(III)离子,甘氨酸,丙氨酸,形貌,氧化钌 公牛。化学。Soc。中国生物医学工程学报,2017,37(6),1443-1457。DOI: https://dx.doi.org/10.4314/bcse.v37i6.12
{"title":"Exploring novel coral reef-like RuO2 oxides: Synthesis and physicochemical characterizations of gatifloxacin-based Ru(III) complexes","authors":"Khaled Althubeiti","doi":"10.4314/bcse.v37i6.12","DOIUrl":"https://doi.org/10.4314/bcse.v37i6.12","url":null,"abstract":"ABSTRACT. Two mixed-ligand complexes of Ru(III) ions were synthesized and used to generate nanostructured RuO2 oxide. Complex A contains gatifloxacin (L1), the amino acid glycine (L2), and Ru(III) ions in a 1:1:1 ratio. Complex B contains gatifloxacin (L1), the amino acid alanine (L3), and Ru(III) ions in a 1:1:1 ratio. The synthesized complexes were characterized using UV-Visible and IR spectroscopies, molar conductance, elemental analyses, thermogravimetry, XRD, and SEM-EDX techniques. In both complexes, the L1 ligand acts as a bidentate and uses the nitrogen atoms of the piperazine ring to capture the Ru(III) ions, while the L2 and L3 ligands capture the Ru(III) ions using their oxygen atom of the carboxylate group and the nitrogen atom of the amino group. The atmosphere around the Ru(III) ion is octahedral, and the complexes were formulated as [RuL1L2(H2O)2]Cl2 and [RuL1L3(H2O)2]Cl2 for Complex A and Complex B, respectively. Complex A was directly decomposed in air at 600 °C for 3 h to produce RuO2 oxide (Oxide A), and complex B was decomposed under the same conditions to produce RuO2 oxide (Oxide B). Morphologically, oxide A and oxide B have a coral reef-like texture with large holes and cavities.
 KEY WORDS: Gatifloxacin, Ru(III) ion, Glycine, Alanine, Morphology, RuO2 oxide
 Bull. Chem. Soc. Ethiop. 2023, 37(6), 1443-1457. DOI: https://dx.doi.org/10.4314/bcse.v37i6.12","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Bulletin of the Chemical Society of Ethiopia
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