Pub Date : 2021-12-15DOI: 10.51580/2021-1/2710-1185.46
E. Yergaliyeva, L. Kayukova, A. Vologzhanina, G. Baitursynova, V. Vazhev
Amidoxime derivatives have practically valuable biological properties. We have previously obtained new spiropyrazolinium compounds by arylsulfo-chlorination of β-aminopropioamidoximes, but in case of β-(benzimidazol-1-yl)pro-pioamidoxime we have obtained O-substitution product – 3-(1H-benzo[d]imidazol-1-yl)-N'-(tosyloxy)pro-panimidamide. The aim of the work is predicting of structural parameters (bond lengths, bond angles), vibrational frequencies and NMR spectra of 3-(1H-benzo-[d]imidazol-1-yl)-N'-(tosyloxy)propanimidamide. The calculations were performed using Gaussian 09 package. Structural parameters and vibrational frequencies was calculated using DFT (B3LYP/B3PW91/WB97XD)/6-31G(d,p). 1H and 13C NMR was predicted using DFT B3LYP/6-31G(d,p)-GIAO in DMSO. All calculated values are in good agreement with experimental data. The calculated bond lengths and bond angles were compared with results of X-ray structural analysis. The best correlation coefficient was 0.981 (calcu-lations with B3LYP level). For bond angles, the best result was obtained with B3LYP level (0.990). For vibrational frequencies correlation coefficients between the calculated and experimental values were 0.997 (B3LYP), 0.996 (B3PW91) and 0.995 (WB97XD). The most accurate method was used for predic-ting NMR spectrum. The correlation coefficients between the experimental and calculated 1H and 13C chemical shifts were 0.949 and 0.999 respectively.
偕胺肟衍生物具有重要的生物学特性。我们以前用芳基磺化氯化法得到了新的螺吡唑啉化合物，但对于β-(苯并咪唑-1-基)原吡唑胺，我们得到了o取代产物- 3-(1h -苯并咪唑-1-基)- n '-(tosyloxy)原吡唑胺。这项工作的目的是预测3-(1h -苯并-[d]咪唑-1-基)- n '-(tosyloxy)丙酰胺的结构参数(键长，键角)，振动频率和核磁共振波谱。使用Gaussian 09软件包进行计算。采用DFT (B3LYP/B3PW91/WB97XD)/6-31G(d,p)计算结构参数和振动频率。用DFT B3LYP/6-31G(d,p)-GIAO在DMSO中预测1H和13C核磁共振。计算值与实验数据吻合较好。将计算得到的键长和键角与x射线结构分析结果进行比较。最佳相关系数为0.981(以B3LYP水平计算)。对于键角，以B3LYP水平(0.990)为最佳。振动频率计算值与实验值的相关系数分别为0.997 (B3LYP)、0.996 (B3PW91)和0.995 (WB97XD)。采用最准确的方法预测核磁共振谱。1H和13C化学位移与实验计算值的相关系数分别为0.949和0.999。
{"title":"DFT STUDIES OF STRUCTURAL PARAMETERS, VIBRATIONAL FREQUENCIES AND NMR SPECTRA OF 3-(1H-BENZO[D]IMIDAZOL-1-YL)-N'-(TOSYLOXY)PROPANIMIDAMIDE","authors":"E. Yergaliyeva, L. Kayukova, A. Vologzhanina, G. Baitursynova, V. Vazhev","doi":"10.51580/2021-1/2710-1185.46","DOIUrl":"https://doi.org/10.51580/2021-1/2710-1185.46","url":null,"abstract":"Amidoxime derivatives have practically valuable biological properties. We have previously obtained new spiropyrazolinium compounds by arylsulfo-chlorination of β-aminopropioamidoximes, but in case of β-(benzimidazol-1-yl)pro-pioamidoxime we have obtained O-substitution product – 3-(1H-benzo[d]imidazol-1-yl)-N'-(tosyloxy)pro-panimidamide. The aim of the work is predicting of structural parameters (bond lengths, bond angles), vibrational frequencies and NMR spectra of 3-(1H-benzo-[d]imidazol-1-yl)-N'-(tosyloxy)propanimidamide. The calculations were performed using Gaussian 09 package. Structural parameters and vibrational frequencies was calculated using DFT (B3LYP/B3PW91/WB97XD)/6-31G(d,p). 1H and 13C NMR was predicted using DFT B3LYP/6-31G(d,p)-GIAO in DMSO. All calculated values are in good agreement with experimental data. The calculated bond lengths and bond angles were compared with results of X-ray structural analysis. The best correlation coefficient was 0.981 (calcu-lations with B3LYP level). For bond angles, the best result was obtained with B3LYP level (0.990). For vibrational frequencies correlation coefficients between the calculated and experimental values were 0.997 (B3LYP), 0.996 (B3PW91) and 0.995 (WB97XD). The most accurate method was used for predic-ting NMR spectrum. The correlation coefficients between the experimental and calculated 1H and 13C chemical shifts were 0.949 and 0.999 respectively.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74984487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-15DOI: 10.51580/2021-1/2710-1185.45
А.А. Agatayeva, U. Jussipbekov, R. Chernyakova, R. Kaiynbayeva, N. Kozhabekova, А.М. Nabiyeva
The processing of phosphorites into elemental phosphorus is accom-panied by the formation of waste - cotrile "milk", in which indium, gallium, and silver are present. This waste can be considered as a cheap raw material for the production of rare and precious metals. In the scientific literature there are data on the sorption capacity of hexacyano-ferrates of iron, which has a crystal lattice with a channel diameter from 3.0 to 3.5Å. Investigation of the sorption process in the model system "Fe4[Fe(CN)6]3·10H2O - Ag+- In3+- Ga3+ - H2O" depending on the norm of iron hexacyanoferrate (sorbent). The initial concentration of silver, indium and gallium ions and their residual content in solutions were determined using the atomic absorption spectrophotometer "PerkinElmer Analyst 400" (USA). The microstructure of the initial iron hexacyanoferrate and iron hexacyano-ferrate, after sorption, was studied on the CarlZeissFESEM and JEOL brand "JXA-8230" (Japan). With a ratio to T:W equal to 1.75-2.5:100, the degree of sorption of Ag+ with iron hexacyanoferrate is 99.5 and 99.8 %. The highest degree of sorption (96.75%) of In3+ ions can be obtained with a sorbent weighing 3 g per 100 g of solution at 60oC. A high degree of sorption of Ga3+ cations is achieved at low (0.5:100 wt. h.) and high (3:100 wt. h.) consumption of iron hexacyanoferrate. It was revealed that iron hexacyanoferrate exhibits sorption properties simultaneously with respect to mono- and trivalent metals, and the basic laws of their sorption were established.
{"title":"INFLUENCE OF THE RATE OF IRON HEXATIANOFERRATE ON ITS SORPTION ABILITY IN RELATION TO SILVER, INDIUM AND GALLIUM CATIONS","authors":"А.А. Agatayeva, U. Jussipbekov, R. Chernyakova, R. Kaiynbayeva, N. Kozhabekova, А.М. Nabiyeva","doi":"10.51580/2021-1/2710-1185.45","DOIUrl":"https://doi.org/10.51580/2021-1/2710-1185.45","url":null,"abstract":"The processing of phosphorites into elemental phosphorus is accom-panied by the formation of waste - cotrile \"milk\", in which indium, gallium, and silver are present. This waste can be considered as a cheap raw material for the production of rare and precious metals. In the scientific literature there are data on the sorption capacity of hexacyano-ferrates of iron, which has a crystal lattice with a channel diameter from 3.0 to 3.5Å. Investigation of the sorption process in the model system \"Fe4[Fe(CN)6]3·10H2O - Ag+- In3+- Ga3+ - H2O\" depending on the norm of iron hexacyanoferrate (sorbent). The initial concentration of silver, indium and gallium ions and their residual content in solutions were determined using the atomic absorption spectrophotometer \"PerkinElmer Analyst 400\" (USA). The microstructure of the initial iron hexacyanoferrate and iron hexacyano-ferrate, after sorption, was studied on the CarlZeissFESEM and JEOL brand \"JXA-8230\" (Japan). With a ratio to T:W equal to 1.75-2.5:100, the degree of sorption of Ag+ with iron hexacyanoferrate is 99.5 and 99.8 %. The highest degree of sorption (96.75%) of In3+ ions can be obtained with a sorbent weighing 3 g per 100 g of solution at 60oC. A high degree of sorption of Ga3+ cations is achieved at low (0.5:100 wt. h.) and high (3:100 wt. h.) consumption of iron hexacyanoferrate. It was revealed that iron hexacyanoferrate exhibits sorption properties simultaneously with respect to mono- and trivalent metals, and the basic laws of their sorption were established.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83779415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-15DOI: 10.51580/2021-1/2710-1185.51
D. Muktaly, Z. Myltykbaeva, M. Smaiyl
Continuous growth in consumption of oil in the world, as well as ever-increasing quality requirements stimulate the search for new scientific and technological solutions to directionally affect the characteristics of petroleum products, including their chemical composition. The advantages of oxidative desulfurization before hydrotreating are the absence of the need to use hydrogen, as well as small capital and energy costs, since the method does not require high temperatures and pressures. The purpose of this work was to study the oxidation process of diesel fuel and to search for the optimal mode of oxidative desulfurization of diesel fuel in the presence of transition metals salts with the addition of mineral acids. The object of the study is a straight-run diesel fraction of the Pavlodar Petrochemical Plant with boiling temperatures of 180-350°C. The oxidation process was carried out with hydrogen peroxide in the presence of salts of the transition metals molybdenum, vanadium and tungsten. The article defined the basic physico-chemical characteristics of straight-run and desulfurized diesel fractions. The optimal catalyst (Na2MoO4) was selected at a molar ratio of metal to sulfur of 1:100 for the oxidation process of straight-run diesel fractions. As a result of oxidative desulfurization of diesel fuel in the presence of sodium molybdenum perox complexes, the total sulfur content decreased by 42.9%, and with the addition of sulfuric acid by 56.5%. An increase in the cetane index from 56.3 to 58.6 was revealed in the presence of sodium molybdate with the addition of sulfuric acid.
{"title":"STUDY OF THE PROCESS OF OXIDATIVE DESULFURIZATION OF DIESEL FUEL IN THE PRESENCE OF CO-CATALYSTS","authors":"D. Muktaly, Z. Myltykbaeva, M. Smaiyl","doi":"10.51580/2021-1/2710-1185.51","DOIUrl":"https://doi.org/10.51580/2021-1/2710-1185.51","url":null,"abstract":"Continuous growth in consumption of oil in the world, as well as ever-increasing quality requirements stimulate the search for new scientific and technological solutions to directionally affect the characteristics of petroleum products, including their chemical composition. The advantages of oxidative desulfurization before hydrotreating are the absence of the need to use hydrogen, as well as small capital and energy costs, since the method does not require high temperatures and pressures. The purpose of this work was to study the oxidation process of diesel fuel and to search for the optimal mode of oxidative desulfurization of diesel fuel in the presence of transition metals salts with the addition of mineral acids. The object of the study is a straight-run diesel fraction of the Pavlodar Petrochemical Plant with boiling temperatures of 180-350°C. The oxidation process was carried out with hydrogen peroxide in the presence of salts of the transition metals molybdenum, vanadium and tungsten. The article defined the basic physico-chemical characteristics of straight-run and desulfurized diesel fractions. The optimal catalyst (Na2MoO4) was selected at a molar ratio of metal to sulfur of 1:100 for the oxidation process of straight-run diesel fractions. As a result of oxidative desulfurization of diesel fuel in the presence of sodium molybdenum perox complexes, the total sulfur content decreased by 42.9%, and with the addition of sulfuric acid by 56.5%. An increase in the cetane index from 56.3 to 58.6 was revealed in the presence of sodium molybdate with the addition of sulfuric acid.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84890275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-15DOI: 10.51580/2021-1/2710-1185.49
L. Soliev, M. Jumaev
The structure of the phase complex of the six-component reciprocal system Na, K, Mg, Ca || SO4, Cl-H2O at 500C in the region of crystallization of anhydrite (CaSO4) was studied by the translation method, and variants of the formation of divariant fields during the transition of the system from the five-component to the six-component state were shown
{"title":"DIVARENT EQUILIBRIUM IN MULTI-COMPONENT SYSTEMS","authors":"L. Soliev, M. Jumaev","doi":"10.51580/2021-1/2710-1185.49","DOIUrl":"https://doi.org/10.51580/2021-1/2710-1185.49","url":null,"abstract":"The structure of the phase complex of the six-component reciprocal system Na, K, Mg, Ca || SO4, Cl-H2O at 500C in the region of crystallization of anhydrite (CaSO4) was studied by the translation method, and variants of the formation of divariant fields during the transition of the system from the five-component to the six-component state were shown","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77758049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-15DOI: 10.51580/2021-1/2710-1185.48
A. Bagirli
Petrochemical products based on petroleum naphthenic acids have special properties. Esters of naphthenic acids possess practically valuable organic compounds. The aim of this work is the development of effective methods for the preparation of aromatic esters based on naphthenic and individual fatty acids which is a very promising direction in the medicine practice. The synthesis of unsaturated racemic and chiral oxyethers was carried out on the basis of the interaction of chloromethylpropargyl (allyl) esters with carbonyl compounds with the participation of metallic zinc. Also, to study the biological activity, racemic and optically active esters were synthesized based on naphthenic acids and unsaturated racemic and chiral oxyesters. As test cultures used: gram-positive (Staphylo-coccus aureus-Staphylococcus aureus), gram-negative (Pseudomonas aeruginosa – Pseu-domonas aeruginosa, Escherichia coli) bacteria, as well as yeast-like fungi of the genus Candida - Candida albicans. Analysis of the biological activity of the synthesized compounds showed that optically active bicyclo [2.2.1] hept-5-ene-2-methylol monoesters have higher antimicrobial and antifungal activity compared to their racemic analogs and drugs used in medicine.
{"title":"STUDY OF BIOLOGICAL ACTIVITY OF RACEMIC AND OPTICALLY ACTIVE ESTERS OF NAPHTHENIC AND FATTY ACIDS BASED ON UNSATURATED OXYESTERS","authors":"A. Bagirli","doi":"10.51580/2021-1/2710-1185.48","DOIUrl":"https://doi.org/10.51580/2021-1/2710-1185.48","url":null,"abstract":"Petrochemical products based on petroleum naphthenic acids have special properties. Esters of naphthenic acids possess practically valuable organic compounds. The aim of this work is the development of effective methods for the preparation of aromatic esters based on naphthenic and individual fatty acids which is a very promising direction in the medicine practice. The synthesis of unsaturated racemic and chiral oxyethers was carried out on the basis of the interaction of chloromethylpropargyl (allyl) esters with carbonyl compounds with the participation of metallic zinc. Also, to study the biological activity, racemic and optically active esters were synthesized based on naphthenic acids and unsaturated racemic and chiral oxyesters. As test cultures used: gram-positive (Staphylo-coccus aureus-Staphylococcus aureus), gram-negative (Pseudomonas aeruginosa – Pseu-domonas aeruginosa, Escherichia coli) bacteria, as well as yeast-like fungi of the genus Candida - Candida albicans. Analysis of the biological activity of the synthesized compounds showed that optically active bicyclo [2.2.1] hept-5-ene-2-methylol monoesters have higher antimicrobial and antifungal activity compared to their racemic analogs and drugs used in medicine.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74632017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-15DOI: 10.51580/2021-1/2710-1185.50
G.K. Mukusheva, A.R. Zhasymbekova, Z. Satpaeva, Е.V. Minayeva, Z. Nurmaganbetov, S. T. Shulgau, О. Nurkenov, Т. Seilkhanov
The alkaloid cytisine is of great importance for modern pharmacological studies. This alkaloid can be used as a component of the supramolecular system with cyclic oligosaccharides, namely β-cyclodextrins, which have a truncated cone-shaped molecule with internal protons Н3 and Н5 and external ones Н2 and Н4. The aim of the work is to obtain inclusion complexes of pharmaceutically active derivatives of the alkaloid cytisine. The inclusion complexes of cytisine alkaloid derivatives with β-CD and 2-HP-β-CD were obtained by the coprecipitation method. Thermogravimetric, differential thermal, and differential scanning calorimetric analyzes were performed. It was shown that inclusion complexes of substrate with cyclodextrin cavity of receptors were formed. The greatest change in the chemical shifts of protons during the formation of supra-molecular complexes occurs with the internal protons H-3 and H-5 of the cyclodextrin cavity. All calculated values are in good agreement with experimental data. The prepa-ration of supramolecular complexes has been proven using a variety of physicochemical methods of analysis. According to DSC data, the process of complexes destruction in the temperature range of 30-610°C was studied in comparison with the data of the initial cyclodextrin. The hemorheological effects of the investigated samples were studied in vitro. Among four samples studied, two samples showed the ability to reduce blood viscosity in vitro in the blood hyperviscosity model.
{"title":"CYCLODEXTRIN INCLUSION COMPLEXES OF PHARMACEUTICALLY ACTIVE DERIVATIVES OF THE CYTISINE ALKALOID AND THEIR HEMORHEOLOGICAL ACTIVITY","authors":"G.K. Mukusheva, A.R. Zhasymbekova, Z. Satpaeva, Е.V. Minayeva, Z. Nurmaganbetov, S. T. Shulgau, О. Nurkenov, Т. Seilkhanov","doi":"10.51580/2021-1/2710-1185.50","DOIUrl":"https://doi.org/10.51580/2021-1/2710-1185.50","url":null,"abstract":"The alkaloid cytisine is of great importance for modern pharmacological studies. This alkaloid can be used as a component of the supramolecular system with cyclic oligosaccharides, namely β-cyclodextrins, which have a truncated cone-shaped molecule with internal protons Н3 and Н5 and external ones Н2 and Н4. The aim of the work is to obtain inclusion complexes of pharmaceutically active derivatives of the alkaloid cytisine. The inclusion complexes of cytisine alkaloid derivatives with β-CD and 2-HP-β-CD were obtained by the coprecipitation method. Thermogravimetric, differential thermal, and differential scanning calorimetric analyzes were performed. It was shown that inclusion complexes of substrate with cyclodextrin cavity of receptors were formed. The greatest change in the chemical shifts of protons during the formation of supra-molecular complexes occurs with the internal protons H-3 and H-5 of the cyclodextrin cavity. All calculated values are in good agreement with experimental data. The prepa-ration of supramolecular complexes has been proven using a variety of physicochemical methods of analysis. According to DSC data, the process of complexes destruction in the temperature range of 30-610°C was studied in comparison with the data of the initial cyclodextrin. The hemorheological effects of the investigated samples were studied in vitro. Among four samples studied, two samples showed the ability to reduce blood viscosity in vitro in the blood hyperviscosity model.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78794898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.51580/2021-1/2710-1185.41
S. Adekenov, Karaganda Kazakhstan Production Holding “Phytochemistry”
This article summarizes the literature data and the results of our own studies on the search for antiviral compounds based on terpenoids, flavonoids, alkaloids. New bimolecular and ketoamide derivatives based on sesquiterpene γ-lactones arglabin, grossheimin and α-santonin were synthesized in quantitative yields up to 80%. The molecular docking method was used to study the “structure-activity” relationship of natural compounds and their derivatives in relation to SARS-Cov-2. The results obtained in silico demonstrated that sesquiterpene γ-lactones and their derivatives inhibit the SARS-Cov-2 spike protein and proteases, as well as the angiotensin-converting enzyme 2. The identified molecules can be considered as candidates for the development of new drugs with antiviral activity on their basis.
{"title":"PLANT SUBSTANCES AS POTENTIAL SOURCE OF ORIGINAL ANTI-VIRUS AGENTS","authors":"S. Adekenov, Karaganda Kazakhstan Production Holding “Phytochemistry”","doi":"10.51580/2021-1/2710-1185.41","DOIUrl":"https://doi.org/10.51580/2021-1/2710-1185.41","url":null,"abstract":"This article summarizes the literature data and the results of our own studies on the search for antiviral compounds based on terpenoids, flavonoids, alkaloids. New bimolecular and ketoamide derivatives based on sesquiterpene γ-lactones arglabin, grossheimin and α-santonin were synthesized in quantitative yields up to 80%. The molecular docking method was used to study the “structure-activity” relationship of natural compounds and their derivatives in relation to SARS-Cov-2. The results obtained in silico demonstrated that sesquiterpene γ-lactones and their derivatives inhibit the SARS-Cov-2 spike protein and proteases, as well as the angiotensin-converting enzyme 2. The identified molecules can be considered as candidates for the development of new drugs with antiviral activity on their basis.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90511045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.51580/2021-1/2710-1185.36
М.B. Umerzakova, R. Sarieva, V. Kravtsova
lopment of arylalicyclic copolyimides based on alicyclic dianhydride, aromatic dianhydrides of benzophenone- and diphenyloxidetetracarboxylic acids with 4,4'-diaminodiphenyl oxide at various ratios of alicyclic and aromatic dianhydrides, as well as various compositions based on these copolymers with low- or other high-molecular compounds that enhance the characteristics of the polymer matrix. Composite films were formed from solutions of the obtained polymer mixtures, and their properties were studied. It was noted that at optimal ratio of components, the films have improved thermal and strength properties, etc., exceeding the analogous properties of the initial arylalicyclic copolymer, while the elasticity has acceptable values for such material. The best characteristics had the composite films formed from a ternary composition of copo-lyimide-polyethylene glycol-alkylated montmorillonite. Metal-containing composite films, along with higher thermal stability compared to unmodified copolyimide, were resistant to aggressive reagents, lower values of specific volume and surface resistance, higher viscosity values, and different colors depending on the nature of the salt. By introducing a silicon-containing compound into the copolyimide solution, the new polymer systems have been obtained, and the porous films could be formed.
{"title":"MODIFIED WITH VARIOUS ADDITIVES ARYLALYCLIC COPOLYIMIDES AND COMPOSITE FILMS BASED ON THEIR BASIS","authors":"М.B. Umerzakova, R. Sarieva, V. Kravtsova","doi":"10.51580/2021-1/2710-1185.36","DOIUrl":"https://doi.org/10.51580/2021-1/2710-1185.36","url":null,"abstract":"lopment of arylalicyclic copolyimides based on alicyclic dianhydride, aromatic dianhydrides of benzophenone- and diphenyloxidetetracarboxylic acids with 4,4'-diaminodiphenyl oxide at various ratios of alicyclic and aromatic dianhydrides, as well as various compositions based on these copolymers with low- or other high-molecular compounds that enhance the characteristics of the polymer matrix. Composite films were formed from solutions of the obtained polymer mixtures, and their properties were studied. It was noted that at optimal ratio of components, the films have improved thermal and strength properties, etc., exceeding the analogous properties of the initial arylalicyclic copolymer, while the elasticity has acceptable values for such material. The best characteristics had the composite films formed from a ternary composition of copo-lyimide-polyethylene glycol-alkylated montmorillonite. Metal-containing composite films, along with higher thermal stability compared to unmodified copolyimide, were resistant to aggressive reagents, lower values of specific volume and surface resistance, higher viscosity values, and different colors depending on the nature of the salt. By introducing a silicon-containing compound into the copolyimide solution, the new polymer systems have been obtained, and the porous films could be formed.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83083054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.51580/2021-1/2710-1185.37
R. Kaiynbayeva, N.N. Kojabekova, G. Sultanbayeva, А.А. Аgatayeva, R. Chernyakova, U. Jussipbekov
Sorbents modified with hydrochloric acid and chitosan based on the Shankanai bridge formation zeolite were obtained, and the effect of drying temperature on the sorption properties of sorbents was studied. It was found that 25 °C is the optimal temperature for obtaining acid-modified zeolite. A chitosan-modified sorbent with good sorption characteristics can be obtained at 25 °C with cation-exchange (COE 68.05 mg-eq/g) and 70°C with anion-exchange (SEC 70.16 mg-eq/g) properties. Physicochemical analysis of modified zeolites showed an increase in the size of voids and channels on the surface of acid-modified zeolite, and when modified with chitosan, the latter is crosslinked with the surface of natural zeolite.
{"title":"INFLUENCE OF THE NATURE OF THE MODIFIER ON THE SORPTION PROPERTIES OF SHANKANAI ZEOLITE","authors":"R. Kaiynbayeva, N.N. Kojabekova, G. Sultanbayeva, А.А. Аgatayeva, R. Chernyakova, U. Jussipbekov","doi":"10.51580/2021-1/2710-1185.37","DOIUrl":"https://doi.org/10.51580/2021-1/2710-1185.37","url":null,"abstract":"Sorbents modified with hydrochloric acid and chitosan based on the Shankanai bridge formation zeolite were obtained, and the effect of drying temperature on the sorption properties of sorbents was studied. It was found that 25 °C is the optimal temperature for obtaining acid-modified zeolite. A chitosan-modified sorbent with good sorption characteristics can be obtained at 25 °C with cation-exchange (COE 68.05 mg-eq/g) and 70°C with anion-exchange (SEC 70.16 mg-eq/g) properties. Physicochemical analysis of modified zeolites showed an increase in the size of voids and channels on the surface of acid-modified zeolite, and when modified with chitosan, the latter is crosslinked with the surface of natural zeolite.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83950682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.51580/2021-1/2710-1185.43
Z. Nurmaganbetov, O.A. Hurkenov, S. Fazylov, G.K. Mukusheva, A. Gazaliyev, Z. Muldakhmetov
The modification of the quinolysin alkaloid lupinine was carried out with the intro-duction of 1,2,3-triazolyl substituents for the hydroxymethylene group in the C-1 position of the quinolysin backbone. The reaction of lupinine with methanesulfochloride in the presence of triethylamine smoothly led to lupinine methanesulfonate, whose further reaction with sodium azide in DMFA led to lupinilazide. 1,3-Dipolar [4+2]-cycloaddition of the resulting azide to alkynes produced more stable 1,2,3-triazole compounds. The interaction of lupinilazide with 2-ethinylpyridine and with alcohols containing a terminal acetylene group (propargyl alcohol, 2-methylbut-3-in -2-ol or hex-5-in -1-ol) proceeded smoothly in the DMFA medium. The reactions were carried out in the presence of an aqueous solution of CuSO4 and sodium ascorbate in DMFA and allowed the corresponding 4-substituted (1S,9aR)-1H-1,2,3-triazol-1-yl to be synthesized with good yields)methyl)octahydro-1H-quinolysins. The results of studying the structural features of synthesized compounds by 1H - and 13C - NMR spectroscopy, as well as data from the two-dimensional COSY (1H-1H) and HMQC (1H-13C) spectra are presented. The values of chemical shifts, multiplicity and integral intensity of 1H and 13C signals in one-dimensional NMR spectra are determined. In the spectra of all synthesized new quinolizi-dinotriazoles, there is a peak of the fragmentary C10H17N ion (150-151 cu), corresponding to the cleavage of the molecule by the C-10 atom of the quinolizidine backbone.
{"title":"SYNTHESIS OF 1,2,3-TRIAZOLO-QUINOLIZIDINES BASED ON THE QUINOLIZIDINE ALKALOID LUPININE","authors":"Z. Nurmaganbetov, O.A. Hurkenov, S. Fazylov, G.K. Mukusheva, A. Gazaliyev, Z. Muldakhmetov","doi":"10.51580/2021-1/2710-1185.43","DOIUrl":"https://doi.org/10.51580/2021-1/2710-1185.43","url":null,"abstract":"The modification of the quinolysin alkaloid lupinine was carried out with the intro-duction of 1,2,3-triazolyl substituents for the hydroxymethylene group in the C-1 position of the quinolysin backbone. The reaction of lupinine with methanesulfochloride in the presence of triethylamine smoothly led to lupinine methanesulfonate, whose further reaction with sodium azide in DMFA led to lupinilazide. 1,3-Dipolar [4+2]-cycloaddition of the resulting azide to alkynes produced more stable 1,2,3-triazole compounds. The interaction of lupinilazide with 2-ethinylpyridine and with alcohols containing a terminal acetylene group (propargyl alcohol, 2-methylbut-3-in -2-ol or hex-5-in -1-ol) proceeded smoothly in the DMFA medium. The reactions were carried out in the presence of an aqueous solution of CuSO4 and sodium ascorbate in DMFA and allowed the corresponding 4-substituted (1S,9aR)-1H-1,2,3-triazol-1-yl to be synthesized with good yields)methyl)octahydro-1H-quinolysins. The results of studying the structural features of synthesized compounds by 1H - and 13C - NMR spectroscopy, as well as data from the two-dimensional COSY (1H-1H) and HMQC (1H-13C) spectra are presented. The values of chemical shifts, multiplicity and integral intensity of 1H and 13C signals in one-dimensional NMR spectra are determined. In the spectra of all synthesized new quinolizi-dinotriazoles, there is a peak of the fragmentary C10H17N ion (150-151 cu), corresponding to the cleavage of the molecule by the C-10 atom of the quinolizidine backbone.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87740257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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