Carbohydrate Polymer Technologies and Applications最新文献_第9页

Chitosan/hydroxyapatite hydrogels for localized drug delivery and tissue engineering: A review

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2024-12-15 DOI: 10.1016/j.carpta.2024.100640

Khashayar Khodaverdi , Seyed Morteza Naghib , M.R. Mozafari , Mehdi Rahmanian

Bone defects arising from fractures and degenerative bone diseases present a substantial global health issue, highlighting the need for effective solutions in bone tissue engineering. Chitosan-hydroxyapatite (CS/HA) composites have emerged as highly promising biomaterials, owing to their biocompatibility, osteoconductive, and suitability for targeted drug delivery. This review examines recent progress in the synthesis, structural properties, and applications of CS/HA composites, along with an analysis of their limitations and potential avenues for enhancement. CS/HA scaffolds are typically fabricated through advanced techniques, including freeze-drying, electrophoretic deposition, and 3D printing. These allow for customized porosity and controlled biodegradation rates that promote cell proliferation and facilitate tissue integration. While effective for non-load-bearing applications, CS/HA hydrogels encounter limitations related to mechanical strength and degradation rates under high-stress conditions, especially when compared to newer materials such as graphene and bioactive glasses. Incorporating bioactive metals (e.g., magnesium, copper) and biodegradable polymers (e.g., PLA, PGA) has shown potential for enhancing mechanical stability and enabling controlled drug release. Additionally, the integration of 3D and 4D printing technologies facilitates the production of patient-specific scaffolds with adjustable pore structures, supporting improved cell adhesion and growth. The development of “smart” CS/HA scaffolds, which respond dynamically to environmental stimuli, further extends the potential for controlled therapeutic agent release, advancing personalized tissue engineering and regenerative medicine. Ongoing research focused on optimizing degradation rates and enhancing scaffold-tissue integration is essential for broadening the clinical applicability of CS/HA composites in bone regeneration. This review underscores the future potential of CS/HA composites and advocates for continued innovation in scaffold design to address the complex requirements of bone tissue engineering.

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引用次数: 0

Impact of water plasticization on dialcohol cellulose fibres melt processing-structure-properties relationship

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2024-12-15 DOI: 10.1016/j.carpta.2024.100642

Enrica Pellegrino , Basel Al-Rudainy , Per A. Larsson , Alberto Fina , Giada Lo Re

Cellulose and its derivatives are considered sustainable alternatives to non-biodegradable fossil-based plastics. Chemically modified cellulose fibres to dialcohol cellulose (DAC) fibres demonstrated a melt processing window between the glass transition and degradation temperatures which enabled their extrusion by using only water as a temporary plasticizer. With the aim of supporting an industrial upscale of DAC fibres, this study investigates the processing design and the feasibility of melt processing, minimizing the moisture. Melt processes-structure-properties relationships were studied by varying the sequence of primary and secondary melt processes, i.e., extrusion and injection moulding, and by changing the moisture content. The effect of moisture and processing design on the fibre structural properties, such as molecular weight, crystallinity, fibre morphology and fibre suspensions rheology, was assessed. Then, the thermomechanical behaviour of the 3D-shaped DAC injected materials was correlated with DAC fibres structural features obtained by the different processing design and moisture content. Our results identified the injection moulding as a milder process for achieving the preparation of 3D-shaped material with enhanced mechanical properties. Moreover, we disclosed the relevance of controlled moisture in the extrusion process for enabling a secondary shaping directly after compounding and the possibility of 3D-shaping DAC fibres after a rehydration step.

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引用次数: 0

Pilot evaluation of thymol-loaded chitosan gel as a complementary topical therapy for cutaneous leishmaniasis

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2024-12-14 DOI: 10.1016/j.carpta.2024.100641

Jebraeel Movaffagh , Bibi Razieh Hosseini Farash , Vahid Mashayekhi Goyonlo , Elhams Moghaddas , Mehdi Zarean , Seyed Aliakbar Shamsian , Saeed Yaghoobi Aval Riabi , Omid Ahmadi , Yousef Sharifi , Azadeh Shahroodi , Mohammadreza Ehsani Ghahramanlouie , Matin Ezzatabadipour , Javad Ghasemi , Seyed Javad Bahri

Objective: Cutaneous leishmaniasis is a parasitic skin disease endemic in Iran, with limited effective treatments. Pentavalent antimony compounds like Glucantime have been the standard treatment for over 60 years, but their toxicity and variable efficacy highlight the need for alternative therapies. This study evaluated the efficacy of thymol-loaded chitosan gel as a complementary topical therapy to standard treatment for wound healing in cutaneous leishmaniasis.

Methods: A chitosan gel containing 5 % and 10 % thymol was formulated and tested for its properties. Patients with confirmed lesions were randomly assigned to four groups, receiving Glucantime alongside either 2 % chitosan gel, or gels loaded with 5 % or 10 % Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation thymol. Wound healing progress was monitored using ImageJ software at days 14, 28, 45, and 60.

Results: The chitosan-thymol gel showed no contamination, with thymol release plateauing after 6 h. All treatment groups showed significant improvement compared to the control (P < 0.05), with the 5 % thymol group exhibiting faster healing at multiple intervals (P < 0.01). No side effects were reported for 5 % thymol, while the 10 % group experienced mild burning.

Conclusion: Thymol-loaded chitosan gel, particularly at 5 %, effectively accelerates wound healing in cutaneous leishmaniasis and is a promising complementary therapy.

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引用次数: 0

Eco-friendly composite hydrogel based on cellulose and bentonite for removal of lead (II): Kinetics and isotherm studies

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2024-12-13 DOI: 10.1016/j.carpta.2024.100637

Abiy Lolasa Obsa , Nurelegne Tefera Shibeshi , Eyobel Mulugeta , Getachew Adam Workeneh

This study developed eco-friendly composite hydrogel based on cellulose and bentonite to remove Pb²⁺ from wastewater. The composite hydrogel adsorbents' morphology, chemical composition, and structure were characterized using FE-SEM, EDX, FT-IR, and XRD. Furthermore, EDX mapping displayed uniform dispersion of bentonite within the cellulose-based hydrogel (H), leading to enhanced swelling capacity and mechanical strength. To optimize the adsorption process, the effect of experimental conditions on the amount of Pb²⁺ adsorbed per bentonite/cellulose-based composite hydrogel (BCH3) was investigated. The batch adsorption results showed that the maximum adsorption capacity of Pb²⁺ onto BCH3 was 110.64 mg g^-1. Post-adsorption EDX spectra and FTIR analysis provided evidence of successful Pb²⁺ uptake by BCH3. The results obtained from these analyses suggest that the primary adsorption mechanism involves the interaction of Pb²⁺ with nitrogen (NH₂) and oxygen (COO^-) groups on the BCH3 surface. Kinetics and isotherm data were best described by the pseudo-second-order (R² = 0.999) and Sips models (R² = 0.996). The kinetic model indicated that Pb²⁺ uptake onto the BCH3 was primarily governed by chemisorption involving coordination bonding/electrostatic interactions. The BCH3 adsorbent exhibited selectivity towards Pb²⁺ compared to Cd²⁺ and demonstrated good reusability after five adsorption-desorption cycles.

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引用次数: 0

Physicochemical, morphological, and rheological properties of cellulose nanofibrils produced via ultra-high-pressure homogenization

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2024-12-13 DOI: 10.1016/j.carpta.2024.100635

Lingxin You , Benoît Marcolini , Jérôme Bour , Patrick Grysan , Yves Fleming , Peter Fischer , Christos Soukoulis

Cellulose nanofibrils (CNFs) possess desirable properties, including low density, high tensile strength, large surface area, and high biodegradability, making them valuable for broad industrial applications. High-pressure homogenization is the most common processing method to produce CNFs. This study reports on the impact of ultra-high-pressure homogenization (UHPH) on the structural and technofunctional properties of CNFs, including their Pickering o/w emulsion stabilizing performance. Microcrystalline cellulose suspensions (0.5 % w/w) were processed at pressures ranging from 500 to 3500 bar for up to 25 passes. According to our findings, the size (fiber length and width) of the CNFs was reduced with pressure increase. The highest colloidal stability of cellulose suspensions was observed at ≥ 2500 bar for at least 5 passes. The viscosity of cellulose suspensions increased progressively with the severity of the UHPH. Dynamic rheological characterization of the cellulose suspensions processed for 25 cycles revealed a true gel-like behavior within the linear viscoelastic regime and a strain stiffening effect at large strains (> 10 %). The lipid droplet polydispersity and creaming index of Pickering emulsions were minimized using the 3500 bar processed CNFs. In conclusion, UHPH is an efficient method to induce the nanofibrillation of cellulose, and improve its techno-functionality.

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引用次数: 0

Comparison of the pH- and NH3-sensitivity of chitosan/polyvinyl alcohol smart films containing anthocyanins or betacyanins for monitoring fish freshness

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2024-12-13 DOI: 10.1016/j.carpta.2024.100639

Reza Abedi-Firoozjah , Shamimeh Azimi-Salim , Arvin Afrah , Mohammad Hadi Moradiyan , Elham Assadpour , Zahra Sarlak , Maryam Azizi-Lalabadi , Danial Dehnad , Seid Mahdi Jafari

In the Persian Gulf and Oman Sea, where silver pomfret (Pampus argenteus) is widely consumed, monitoring its freshness is highly important to guarantee its safety, quality, and economic value. Traditional methods of assessing seafood freshness are usually subjective or involve complicated lab analyses that can hardly be viable within a supply chain environment. This comparative study addresses the gap by developing smart halochromic films using chitosan (CS) and polyvinyl alcohol (PVA), incorporated with different contents of Sambucus nigra L. anthocyanins (SNA; 4, 6 and 8 %) or red beetroot betacyanin (RBB; 10, 20 and 30 %). SEM images and FTIR spectra revealed that both SNA and RBB were uniformly distributed within the biopolymeric matrix, demonstrating significant molecular interactions such as hydrogen and electrostatic connections. However, the films rich in RBB exhibited irregular and rough surfaces with small pores. Both SNA/RBB-rich films displayed effective antioxidant activity and pH/ammonia-sensitivity; in addition, SNA-rich films outperformed the others. Under simulated supply chain conditions, PVA/CS indicators reliably indicated the freshness of fish fillets stored at 4 and 25 °C, correlating with the accumulation of ammonia gases and pH changes in the package's headspace. The SNA-rich indicators had more pronounced visual color changes.

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引用次数: 0

Double cross-linking oxidized sodium alginate with Ag-based metal-organic framework and borax as an antibacterial spray-filming hydrogel for bacterial barrier

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2024-12-09 DOI: 10.1016/j.carpta.2024.100629

Siamak Javanbakht, Reza Mohammadi

Hydrogels with spray-filming ability still face difficulties preventing infections, mainly when used on mass wounds. These challenges arise due to their lack of flexibility, antibacterial activity, and slow protective film formation on the wound. This study developed a spray-filming hydrogel using an amine-functionalized silver-based metal-organic framework (Ag-MOF), oxidized alginate (O-Alg), and borax (BX). The designed double cross-linked O-Alg/Ag-MOF/BX hydrogel exhibited superior spray-filming ability by utilizing dynamic Schiff base and boronic ester bonds. Various methods were employed to analyze and confirm the structure and characteristics of the hydrogel films. Furthermore, the gelation process of O-Alg/Ag-MOF/BX hydrogel was found to occur within 5–30 s, allowing for rapid film formation through spray application of the two-precursor mixture. An antibacterial study showed significant activity against gram-negative and positive bacteria, with an inhibition zone measuring about 1.3 ± 0.1 cm. Notably, the bacterial barriers test demonstrated that the O-Alg/Ag-MOF/BX hydrogel films effectively prevented the growth of E. coli and S. aureus for 12 h The hydrogels also exhibited good cytocompatibility with human skin fibroblast cells (HFF-1, over 70 % cell viability). As a result, the O-Alg/Ag-MOF/BX hydrogel holds a promising bio-platform for potential use in wound dressings, particularly in scenarios involving large and irregularly shaped injuries.

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引用次数: 0

Potential of chitosan for targeted mitochondrial delivery of therapeutic agents

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2024-12-09 DOI: 10.1016/j.carpta.2024.100634

Deepika Yadav , Rishabha Malviya , Waleed Y. Rizg , Musarrat Husain Warsi

Background

Chitosan, an innately sourced polymer, is esteemed for its biological compatibility and breakdown. Its cationic properties enable good interaction with diverse biological molecules, particularly beneficial in drug-delivery systems. Its capacity to target intracellular components, such as mitochondria, renders it a crucial substance in biomedical research.

Aim

This paper seeks to examine the efficacy of chitosan-based nanoparticles for targeted medication delivery to mitochondria, particularly in the context of cancer treatment. The aim is to improve drug bioavailability, stability, and efficacy through the chemical modification of chitosan. The document additionally explores its extensive applications in gene therapy and vaccination administration.

Discussion

The electrostatic characteristics of chitosan and its capacity to create diverse structures such as hydrogels and nanoparticles facilitate targeted medication release and enhanced cellular absorption. This biopolymer improves the specificity of cancer cells while reducing toxicity to healthy cells. The paper examines chitosan's interaction with cellular membranes and mitochondria to optimize therapeutic results.

Conclusion

Chitosan nanoparticles have considerable promise in the targeted delivery of drugs to mitochondria, especially in the context of cancer therapy. Their cationic properties enhance bioavailability; yet, issues related to solubility and safety require resolution. Further study is required to optimize these nanoparticles for safe and effective application in clinical environments.

{"title":"Potential of chitosan for targeted mitochondrial delivery of therapeutic agents","authors":"Deepika Yadav , Rishabha Malviya , Waleed Y. Rizg , Musarrat Husain Warsi","doi":"10.1016/j.carpta.2024.100634","DOIUrl":"10.1016/j.carpta.2024.100634","url":null,"abstract":"<div><h3>Background</h3><div>Chitosan, an innately sourced polymer, is esteemed for its biological compatibility and breakdown. Its cationic properties enable good interaction with diverse biological molecules, particularly beneficial in drug-delivery systems. Its capacity to target intracellular components, such as mitochondria, renders it a crucial substance in biomedical research.</div></div><div><h3>Aim</h3><div>This paper seeks to examine the efficacy of chitosan-based nanoparticles for targeted medication delivery to mitochondria, particularly in the context of cancer treatment. The aim is to improve drug bioavailability, stability, and efficacy through the chemical modification of chitosan. The document additionally explores its extensive applications in gene therapy and vaccination administration.</div></div><div><h3>Discussion</h3><div>The electrostatic characteristics of chitosan and its capacity to create diverse structures such as hydrogels and nanoparticles facilitate targeted medication release and enhanced cellular absorption. This biopolymer improves the specificity of cancer cells while reducing toxicity to healthy cells. The paper examines chitosan's interaction with cellular membranes and mitochondria to optimize therapeutic results.</div></div><div><h3>Conclusion</h3><div>Chitosan nanoparticles have considerable promise in the targeted delivery of drugs to mitochondria, especially in the context of cancer therapy. Their cationic properties enhance bioavailability; yet, issues related to solubility and safety require resolution. Further study is required to optimize these nanoparticles for safe and effective application in clinical environments.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100634"},"PeriodicalIF":6.2,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Removal of heavy metal ions from wastewater using modified cornstalk cellulose-derived poly(amidoxime) ligand

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2024-12-07 DOI: 10.1016/j.carpta.2024.100633

Md Lutfor Rahman , Siti Aisyah Shamrih , Nurul Afifah Azlyzan , Mohd Sani Sarjadi , Sazmal Effendi Arsad , Shaheen M. Sarkar , Sandeep Kumar

The use of modified cellulose for the removal of heavy metal ions is a promising method to enhance the efficiency of metal ion extraction from water. In this study, cellulose was grafted with acrylonitrile to produce a polyacrylonitrile-grafted cellulose. This product was further converted into a poly(amidoxime) ligand through amidoximation. The structures of the cellulose, grafted cellulose, and poly(amidoxime) ligand were characterized using FT-IR, FE-SEM, and thermogravimetric analysis (TGA). A batch adsorption study was conducted to assess the polymer ligand's ability to adsorb heavy metal ions, including Cu²⁺, Fe²⁺, Co²⁺, Cr³⁺, and Ni²⁺. The poly(amidoxime) ligand demonstrated exceptional Cu²⁺ adsorption capacity, primarily due to the complexation of amidoxime functional groups, with a maximum adsorption capacity of 310 mg g⁻¹ at an optimal pH of 6. Adsorption behavior was found to be pH-dependent, with various metal concentrations tested at a constant pH of 6. The Cu²⁺ ions exhibited highest adsorption capacity, followed by Fe²⁺, Co²⁺, Cr³⁺, and Ni²⁺, with adsorption capacities of 280, 240, 220, and 205 mg g⁻¹, respectively. The adsorption isotherms were well described by the Freundlich model, showing a high correlation coefficient (R² > 0.99), indicating a heterogeneous adsorption surface capable of forming multiple layers on the polymer ligand. Additionally, the adsorption kinetics followed a pseudo-second-order model (R² > 0.997). This poly(amidoxime) ligand was able to remove 90–98 % of toxic metals from industrial wastewater, highlighting its potential for large-scale environmental applications. The development of poly(amidoxime) ligands from cellulosic materials offers a sustainable and eco-friendly approach to heavy metal ion extraction.

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引用次数: 0

Living electronics in cellulose zoogleal mats

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2024-12-07 DOI: 10.1016/j.carpta.2024.100627

Panagiotis Mougkogiannis , Anna Nikolaidou , Andrew Adamatzky

The review starts by investigating the concepts that underpin the use of kombucha in electronic systems, such as its conducting properties, self-healing properties, and capacity to form long-lasting biofilms. The research explores the diverse uses of kombucha-based living electronics, including biosensors, biocomputing devices, energy harvesting systems, and flexible electronics. Proteinoids, a synthetic class of polypeptides, have attracted researchers’ interest because of their structural and functional analogies to natural proteins. This similarity offers numerous opportunities for their usage in diverse fields, such as the development of cutting-edge living electronic systems. This paper analyses the fundamental concepts of integrating proteinoids into living electrical systems, with a specific emphasis on their distinct structural and functional characteristics. The paper explores the possible uses of proteinoid-based electronics, including molecular switches, memory devices, and self-assembling nanostructures, emphasising their superiority to traditional electronic components. Nevertheless, the incorporation of kombucha and proteinoids into living electronics presents several difficulties. These technical challenges affect the production, durability, and expandability of these bio-hybrid systems. Furthermore, this article tackles concerns about biocompatibility, durability, and the necessity for standardised characterisation methodologies.

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引用次数: 0