Pub Date : 2024-08-27DOI: 10.1149/2162-8777/ad6f42
Balamurugapandian N, Suganya K, Hariharasuthan R, Jayanalina T, Swarnalatha V, SenthilKannan K, Manikandan R
The Zinc Acetate - ZA is grown in 16–17 days as colorless crystal by slow evaporation manner; in the present work, the shocked pulses of range of 50 scaling of ZA-100 Gy irradiated sample is represented after the pulsed reference of shock waves as ZA-100Gy-50S in physical reference, the single crystalline XRD data of ZA-100Gy-50S is having 15.108, 9.254, 4.7999 of a, b, c values in Å and beta as 99.12° with P21/c as space group and monoclinic as the system; the UV-visible spectral cut-off wavelength for ZA-100Gy-50S is 224 nm; the band gap in eV as 5.53 from Tauc’s plot and is 5.5357 eV from UV-visible data. The Fluorescence wavelength gives the energy impact of 2.4047 eV. The NLO-SHG as 1.34 times than the standard KDP and the phase matching proviso of ZA-100Gy-50S is 93.8 mV The surface morphological impact of ZA-100Gy-50S crystal is with small cracks, no major flaws; the third-order NLO of ZA-100Gy-50S is of 13.92 × 10–6 esu by Z-Scan; the frequency doubling circuit and frequency tripling circuit are analyzed for the ZA-100Gy-50S and are 2.28 times, 3.23 times the input. The (111) based displaying of the display action with Red-Green-Blue filled polygonal effect.
{"title":"Synthesis, Studies of Shocked Pulse of 50 Scale on 100 Gy Irradiated Zinc Acetate Crystals for Photonic, NLO, Phase-Matching and Electronic Utilities","authors":"Balamurugapandian N, Suganya K, Hariharasuthan R, Jayanalina T, Swarnalatha V, SenthilKannan K, Manikandan R","doi":"10.1149/2162-8777/ad6f42","DOIUrl":"https://doi.org/10.1149/2162-8777/ad6f42","url":null,"abstract":"The Zinc Acetate - ZA is grown in 16–17 days as colorless crystal by slow evaporation manner; in the present work, the shocked pulses of range of 50 scaling of ZA-100 Gy irradiated sample is represented after the pulsed reference of shock waves as ZA-100Gy-50S in physical reference, the single crystalline XRD data of ZA-100Gy-50S is having 15.108, 9.254, 4.7999 of a, b, c values in Å and beta as 99.12° with P2<sub>1</sub>/c as space group and monoclinic as the system; the UV-visible spectral cut-off wavelength for ZA-100Gy-50S is 224 nm; the band gap in eV as 5.53 from Tauc’s plot and is 5.5357 eV from UV-visible data. The Fluorescence wavelength gives the energy impact of 2.4047 eV. The NLO-SHG as 1.34 times than the standard KDP and the phase matching proviso of ZA-100Gy-50S is 93.8 mV The surface morphological impact of ZA-100Gy-50S crystal is with small cracks, no major flaws; the third-order NLO of ZA-100Gy-50S is of 13.92 × 10<sup>–6</sup> esu by Z-Scan; the frequency doubling circuit and frequency tripling circuit are analyzed for the ZA-100Gy-50S and are 2.28 times, 3.23 times the input. The (111) based displaying of the display action with Red-Green-Blue filled polygonal effect.","PeriodicalId":11496,"journal":{"name":"ECS Journal of Solid State Science and Technology","volume":"14 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-27DOI: 10.1149/2162-8777/ad6eb7
Heba Abdel Hafeez Ismail, Doaa Ahmed El-Setouhy, Basant A. Habib, Eman Abdelhakeem, Amany M. El Nahrawy
This study explores the microstructure, spectroscopic, and bonding arrangements within bioactive calcium silicate and calcium magnesium silicate systems loaded with different values (1–2.5 wt%) Coenzyme (CoQ10) ratios, synthesized using sol-gel processes. The investigation utilizes X-ray diffraction (XRD), transmission electron microscopy, and Fourier transform infrared (FTIR) spectroscopy to analyze the samples. The study explores the assignment of FTIR bonds, examining changes in the silicate-based bonds environment under the effect of the CoQ10 ratio. The observed frequency shifts and intensity variations in FTIR bonds, linked with the bioactive silicate composition, are attributed to a reduction in local symmetry resulting from introducing the calcium and magnesium oxides and CoQ10 to the silica network. The XRD and FTIR results contribute valuable insights into the structural role of silicate-based materials loaded with CoQ10, thereby enhancing our understanding of the CoQ10 release process. Approval of the CoQ10 drug loading in both calcium silicate and calcium magnesium silicate nanosystems was recognized by shifts in FTIR bands, changes in particle distribution, and the valuation of drug release activity showed by the bioactive two calcium silicate-based nanoparticles. Additionally, wound healing studies revealed the biocompatibility and wound healing response of calcium magnesium silicate nanoparticles.
{"title":"Synthesis and Characterization of Coenzyme Q10 onto Nanoporous Calcium Silicate-Based Systems for Wound Healing","authors":"Heba Abdel Hafeez Ismail, Doaa Ahmed El-Setouhy, Basant A. Habib, Eman Abdelhakeem, Amany M. El Nahrawy","doi":"10.1149/2162-8777/ad6eb7","DOIUrl":"https://doi.org/10.1149/2162-8777/ad6eb7","url":null,"abstract":"This study explores the microstructure, spectroscopic, and bonding arrangements within bioactive calcium silicate and calcium magnesium silicate systems loaded with different values (1–2.5 wt%) Coenzyme (CoQ<sub>10</sub>) ratios, synthesized using sol-gel processes. The investigation utilizes X-ray diffraction (XRD), transmission electron microscopy, and Fourier transform infrared (FTIR) spectroscopy to analyze the samples. The study explores the assignment of FTIR bonds, examining changes in the silicate-based bonds environment under the effect of the CoQ10 ratio. The observed frequency shifts and intensity variations in FTIR bonds, linked with the bioactive silicate composition, are attributed to a reduction in local symmetry resulting from introducing the calcium and magnesium oxides and CoQ<sub>10</sub> to the silica network. The XRD and FTIR results contribute valuable insights into the structural role of silicate-based materials loaded with CoQ<sub>10</sub>, thereby enhancing our understanding of the CoQ<sub>10</sub> release process. Approval of the CoQ<sub>10</sub> drug loading in both calcium silicate and calcium magnesium silicate nanosystems was recognized by shifts in FTIR bands, changes in particle distribution, and the valuation of drug release activity showed by the bioactive two calcium silicate-based nanoparticles. Additionally, wound healing studies revealed the biocompatibility and wound healing response of calcium magnesium silicate nanoparticles.","PeriodicalId":11496,"journal":{"name":"ECS Journal of Solid State Science and Technology","volume":"11 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-27DOI: 10.1149/2162-8777/ad6fd0
Maria Khalil, Aneeqa Bashir, Umara Khalil, Farman Ullah, Shahid M. Ramay, Murtaza Saleem
Doping non-metal elements into Cr2O3 can tailor its properties, making it more efficient for applications like sensors or photocatalysis. For this purpose, the current research work presents the impact of nitrogen doping on the structural and optical properties of Cr2O3 thin films. Pure and N-doped Cr2O3 (Cr2O3−xNx) thin films were synthesized using the DC reactive magnetron sputtering approach. The stoichiometry was obtained by raising values of x, where x = 0, 0.125, 0.25, and 0.50. X-ray diffraction analysis confirmed the rhombohedral crystal structure without the presence of any other secondary phase in undoped and N-doped Cr2O3 thin films. Furthermore, crystallinity and average crystallite size have enhanced by doping. Field emission scanning electron micrographs disclosed that the surface morphology of the prepared samples changed considerably with doping. A thorough optical investigation was carried out by spectroscopic ellipsometry. Several optical properties significantly changed with dopant content. The reduction in the optical bandgap from 2.50 eV to 1.82 eV, with N-doping was observed. The study demonstrated that N-doping improves the structural and optical properties that make it a promising candidate for optoelectronic applications.
在 Cr2O3 中掺入非金属元素可以调整其特性，使其在传感器或光催化等应用中更加有效。为此，目前的研究工作介绍了掺氮对 Cr2O3 薄膜结构和光学特性的影响。采用直流反应磁控溅射法合成了纯的和掺氮的 Cr2O3（Cr2O3-xNx）薄膜。通过提高 x 值（x = 0、0.125、0.25 和 0.50）获得了化学计量。X 射线衍射分析证实，未掺杂和掺 N 的 Cr2O3 薄膜具有斜方晶体结构，不存在任何其他次生相。此外，结晶度和平均晶粒大小也因掺杂而提高。场发射扫描电子显微镜照片显示，制备的样品表面形态随着掺杂发生了很大变化。通过光谱椭偏仪进行了全面的光学研究。随着掺杂剂含量的增加，一些光学特性发生了明显变化。据观察，掺入 N 后，光带隙从 2.50 eV 减小到 1.82 eV。研究表明，掺杂 N 可改善结构和光学特性，使其成为光电应用的理想候选材料。
{"title":"Structural and Optical Properties of Magnetron-Sputtered Chromium Oxynitride Thin Films","authors":"Maria Khalil, Aneeqa Bashir, Umara Khalil, Farman Ullah, Shahid M. Ramay, Murtaza Saleem","doi":"10.1149/2162-8777/ad6fd0","DOIUrl":"https://doi.org/10.1149/2162-8777/ad6fd0","url":null,"abstract":"Doping non-metal elements into Cr<sub>2</sub>O<sub>3</sub> can tailor its properties, making it more efficient for applications like sensors or photocatalysis. For this purpose, the current research work presents the impact of nitrogen doping on the structural and optical properties of Cr<sub>2</sub>O<sub>3</sub> thin films. Pure and N-doped Cr<sub>2</sub>O<sub>3</sub> (Cr<sub>2</sub>O<sub>3−x</sub>N<sub>x</sub>) thin films were synthesized using the DC reactive magnetron sputtering approach. The stoichiometry was obtained by raising values of x, where x = 0, 0.125, 0.25, and 0.50. X-ray diffraction analysis confirmed the rhombohedral crystal structure without the presence of any other secondary phase in undoped and N-doped Cr<sub>2</sub>O<sub>3</sub> thin films. Furthermore, crystallinity and average crystallite size have enhanced by doping. Field emission scanning electron micrographs disclosed that the surface morphology of the prepared samples changed considerably with doping. A thorough optical investigation was carried out by spectroscopic ellipsometry. Several optical properties significantly changed with dopant content. The reduction in the optical bandgap from 2.50 eV to 1.82 eV, with N-doping was observed. The study demonstrated that N-doping improves the structural and optical properties that make it a promising candidate for optoelectronic applications.","PeriodicalId":11496,"journal":{"name":"ECS Journal of Solid State Science and Technology","volume":"67 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-27DOI: 10.1149/2162-8777/ad6fd1
L. M. El-Khalawany, S. A. Gad, A. M. Moustafa, A. Nassar, E. M. El-Menyawy
Iron tris(8-hydroxyquinoline) (Feq3) was synthesized and investigated by X-ray photoemission spectroscopy. It crystalizes in triclinic polycrystalline structure in powder form, whereas the Feq3 films, with different thickness values (12, 20, 35, and 42 nm), have an amorphous structure. The influence of film thickness on the electrical resistivity and the optical properties is reported. The morphology of Feq3 was investigated in terms of field-emission scanning electron microscope. Electrical resistivity measurements indicate an inverse proportionality to the film thickness. The optical properties of Feq3 films were investigated in terms of photoluminescence spectra and spectrophotometric measurements of transmittance and reflectance. The optical functions such as absorption coefficient and refractive index of the films were calculated. The dependence of the Feq3 film thickness on the optical energy band gap and dispersion parameters was studied. The outcomes indicate that the Feq3 films are of great importance for applications in organic solar cells and light emitting diodes.
{"title":"Effect of Film Thickness on the Electrical Resistivity and Optical Functions Distribution of Iron Tris(8-hydroxyquinoline) Thin Films","authors":"L. M. El-Khalawany, S. A. Gad, A. M. Moustafa, A. Nassar, E. M. El-Menyawy","doi":"10.1149/2162-8777/ad6fd1","DOIUrl":"https://doi.org/10.1149/2162-8777/ad6fd1","url":null,"abstract":"Iron tris(8-hydroxyquinoline) (Feq<sub>3</sub>) was synthesized and investigated by X-ray photoemission spectroscopy. It crystalizes in triclinic polycrystalline structure in powder form, whereas the Feq<sub>3</sub> films, with different thickness values (12, 20, 35, and 42 nm), have an amorphous structure. The influence of film thickness on the electrical resistivity and the optical properties is reported. The morphology of Feq<sub>3</sub> was investigated in terms of field-emission scanning electron microscope. Electrical resistivity measurements indicate an inverse proportionality to the film thickness. The optical properties of Feq<sub>3</sub> films were investigated in terms of photoluminescence spectra and spectrophotometric measurements of transmittance and reflectance. The optical functions such as absorption coefficient and refractive index of the films were calculated. The dependence of the Feq<sub>3</sub> film thickness on the optical energy band gap and dispersion parameters was studied. The outcomes indicate that the Feq<sub>3</sub> films are of great importance for applications in organic solar cells and light emitting diodes.","PeriodicalId":11496,"journal":{"name":"ECS Journal of Solid State Science and Technology","volume":"10 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-27DOI: 10.1149/2162-8777/ad6fd3
Ying-Chen Chen, Chih-Yang Lin, Chang-Hsien Lin, Chao-Cheng Lin
In this work, bilayer self-rectified memristors for highly scalable memory arrays have been realized in bilayer stacked structures for suppressing the sneak path current without an additional switch device integration. This is a groundbreaking development for high-density storage memory applications. The programmable reconfigurations and operational polarities on self-rectified memristor with temperature response on dielectric fusing phenomena with the impact of electrode thermal conductivity have been investigated. The nonlinear bifunctional memristor with low voltage dielectric fusing operation is also presented for reprogrammable read-only memory applications as the future features for security in artificial intelligence and internet hardware systems.
{"title":"Bimodal Reconfigurable Memristor and Read-Only Operations Coexisting in HfOx-Based Stacked Structures","authors":"Ying-Chen Chen, Chih-Yang Lin, Chang-Hsien Lin, Chao-Cheng Lin","doi":"10.1149/2162-8777/ad6fd3","DOIUrl":"https://doi.org/10.1149/2162-8777/ad6fd3","url":null,"abstract":"In this work, bilayer self-rectified memristors for highly scalable memory arrays have been realized in bilayer stacked structures for suppressing the sneak path current without an additional switch device integration. This is a groundbreaking development for high-density storage memory applications. The programmable reconfigurations and operational polarities on self-rectified memristor with temperature response on dielectric fusing phenomena with the impact of electrode thermal conductivity have been investigated. The nonlinear bifunctional memristor with low voltage dielectric fusing operation is also presented for reprogrammable read-only memory applications as the future features for security in artificial intelligence and internet hardware systems.","PeriodicalId":11496,"journal":{"name":"ECS Journal of Solid State Science and Technology","volume":"30 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-23DOI: 10.1149/2162-8777/ad6c7e
Mingze Gao, Zhongyuan Li, Weifeng Sun
This study explores and verifies the chemical modifications achieved by grafting 4-formylcyclohexyl heptanoate (FH) and 4-(2,5-dioxopyrrolidin-1-yl) cyclohexane-1-carbaldehyde (CC) onto ethylene propylene diene monomer (EPDM) elastomer, a prevalent dielectric material used for reinforced insulation in cable accessories. Employing a rigorous theoretical methodology combining first-principles calculations, molecular dynamics, and Monte Carlo molecular simulations, we elucidate the intricate effects of these chemical-graft modifications on the polymeric structure of EPDM to resist charge transport, moisture-aging, and thermal impact of partial discharge. Our investigation uncovers the emergence of both shallow and deep charge traps within the material, effectively mitigating electron avalanche breakdown. Additionally, we scrutinize the influence of two proposed organic species, acting as grafting agents, on several crucial properties of EPDM including water adsorption uptake, heat capacity, molecular thermal vibration, and polymer pyrolysis. These modifications substantially bolster EPDM’s resistance to high-temperature electrical breakdown and water thermodynamic adsorption, while also enhancing its thermal stability, rendering the proposed chemical-graft modifications an effective way and underling mechanisms for ameliorating electrical insulation performances of EPDM elastomer. Our findings highlight the significant potential of graft modification in molecular structures through comprehensive molecular simulations, offering valuable insights for advancing competent elastomeric polymers in cable accessory insulation.
{"title":"Molecular Simulation Insights into Chemical-Grafted EPDM for Improving Charge Traps, Moisture Resistance, and Pyrolysis Tolerance","authors":"Mingze Gao, Zhongyuan Li, Weifeng Sun","doi":"10.1149/2162-8777/ad6c7e","DOIUrl":"https://doi.org/10.1149/2162-8777/ad6c7e","url":null,"abstract":"This study explores and verifies the chemical modifications achieved by grafting 4-formylcyclohexyl heptanoate (FH) and 4-(2,5-dioxopyrrolidin-1-yl) cyclohexane-1-carbaldehyde (CC) onto ethylene propylene diene monomer (EPDM) elastomer, a prevalent dielectric material used for reinforced insulation in cable accessories. Employing a rigorous theoretical methodology combining first-principles calculations, molecular dynamics, and Monte Carlo molecular simulations, we elucidate the intricate effects of these chemical-graft modifications on the polymeric structure of EPDM to resist charge transport, moisture-aging, and thermal impact of partial discharge. Our investigation uncovers the emergence of both shallow and deep charge traps within the material, effectively mitigating electron avalanche breakdown. Additionally, we scrutinize the influence of two proposed organic species, acting as grafting agents, on several crucial properties of EPDM including water adsorption uptake, heat capacity, molecular thermal vibration, and polymer pyrolysis. These modifications substantially bolster EPDM’s resistance to high-temperature electrical breakdown and water thermodynamic adsorption, while also enhancing its thermal stability, rendering the proposed chemical-graft modifications an effective way and underling mechanisms for ameliorating electrical insulation performances of EPDM elastomer. Our findings highlight the significant potential of graft modification in molecular structures through comprehensive molecular simulations, offering valuable insights for advancing competent elastomeric polymers in cable accessory insulation.","PeriodicalId":11496,"journal":{"name":"ECS Journal of Solid State Science and Technology","volume":"161 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-22DOI: 10.1149/2162-8777/ad6eb6
Hsiao-Hsuan Wan, Haochen Zhu, Chao-Ching Chiang, Xinyi Xia, Jian-Sian Li, Fan Ren, Cheng-Tse Tsai, Yu-Te Liao, Tai-Cheng Chou, Dan Neal, Joseph Katz, Josephine F. Esquivel-Upshaw
Oral leukoplakia (OL) or white patched in the oral cavity poses a diagnostic challenge in oral health due to its white patches on the oral mucosa, affecting 1%-2% of the population, predominantly those over 40 years old. Despite being often benign, OL often precedes potentially malignant disorders and oral cancer, necessitating early detection and intervention. The search for novel biomarkers has intensified, with interleukin-6 (IL-6) emerging as a promising candidate. IL-6 detection levels in saliva offer a non-invasive approach, aiding an accurate risk assessment and treatment planning. Here, we introduce an IL-6-based biosensor for rapid concentration detection. A novel, hour-long functionalization method streamlines mass production, maintaining a low detection limit down to 10−15 g ml−1, which is three order lower than current commercial ELISA kits, with a sensitivity around 18/dec. Utilizing a specially designed printed circuit board with double pulse technology ensures precise concentration results, with human sample tests confirming the biosensor’s efficacy in real-world applications. This innovation represents a significant advancement in early OL detection, enabling timely intervention to prevent its progression to more severe forms of oral cancer.
口腔白斑病（OL）或口腔白斑是口腔健康诊断中的一项挑战，因为口腔黏膜上的白斑会影响 1%-2%的人群，主要是 40 岁以上的人群。尽管 OL 通常是良性的，但它往往先于潜在的恶性疾病和口腔癌，因此需要及早发现和干预。对新型生物标志物的研究不断深入，其中白细胞介素-6（IL-6）是一个很有希望的候选标志物。唾液中的 IL-6 检测水平提供了一种非侵入性方法，有助于准确的风险评估和治疗规划。在此，我们介绍一种基于 IL-6 的生物传感器，用于快速浓度检测。新颖的、长达一小时的功能化方法简化了批量生产，使检测限低至 10-15 g ml-1，比目前的商用酶联免疫吸附试剂盒低三个数量级，灵敏度约为 18/dec。利用专门设计的印刷电路板和双脉冲技术确保了精确的浓度结果，人体样本测试证实了生物传感器在实际应用中的功效。这一创新代表了早期 OL 检测领域的重大进步，能够及时干预，防止其发展为更严重的口腔癌。
{"title":"Functionalization Process for Commercial Viability: Oral Leukoplakia Detection Using IL-6 Biomarker","authors":"Hsiao-Hsuan Wan, Haochen Zhu, Chao-Ching Chiang, Xinyi Xia, Jian-Sian Li, Fan Ren, Cheng-Tse Tsai, Yu-Te Liao, Tai-Cheng Chou, Dan Neal, Joseph Katz, Josephine F. Esquivel-Upshaw","doi":"10.1149/2162-8777/ad6eb6","DOIUrl":"https://doi.org/10.1149/2162-8777/ad6eb6","url":null,"abstract":"Oral leukoplakia (OL) or white patched in the oral cavity poses a diagnostic challenge in oral health due to its white patches on the oral mucosa, affecting 1%-2% of the population, predominantly those over 40 years old. Despite being often benign, OL often precedes potentially malignant disorders and oral cancer, necessitating early detection and intervention. The search for novel biomarkers has intensified, with interleukin-6 (IL-6) emerging as a promising candidate. IL-6 detection levels in saliva offer a non-invasive approach, aiding an accurate risk assessment and treatment planning. Here, we introduce an IL-6-based biosensor for rapid concentration detection. A novel, hour-long functionalization method streamlines mass production, maintaining a low detection limit down to 10<sup>−15</sup> g ml<sup>−1</sup>, which is three order lower than current commercial ELISA kits, with a sensitivity around 18/dec. Utilizing a specially designed printed circuit board with double pulse technology ensures precise concentration results, with human sample tests confirming the biosensor’s efficacy in real-world applications. This innovation represents a significant advancement in early OL detection, enabling timely intervention to prevent its progression to more severe forms of oral cancer.","PeriodicalId":11496,"journal":{"name":"ECS Journal of Solid State Science and Technology","volume":"23 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-21DOI: 10.1149/2162-8777/ad68a2
Youngwook Park, Hokyoung Jung, Doyeon Kim, Taekyung Lee, Haedo Jeong, Hyoungjae Kim
We investigated the impact of the designed contact area (DCA) and designed contact length (DCL) on material removal rates (MRR) when using a pad with a structured surface in chemical mechanical polishing. The structure of the structured surface pad (SSP) was precisely defined, and an examination was conducted to assess the influence of variations in the shape, size, and spacing of the unit figure (UF) on the MRR. The results revealed that maintaining the DCA constant while altering the UF shape to extend the DCL led to a 203% increase in the MRR. Furthermore, modifications in the UF size enhanced the MRR by approximately 630%. The relationship between the DCL and MRR was dependent on the DCA. The characteristics of the SSP, particularly the concentrated pressure and involvement of slurry particles at the edges of the contact area, indicated that an increase in the DCL could augment the active slurry particles. This study offers valuable insights into the pad figure structure, simultaneously advancing our understanding of the pad surface topography and its influence on material removal. By focusing on both structural engineering and practical applications, this study paves the way for future research and enables further exploration in this field.
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In this paper, an analytical model for a novel design dielectric modulated plasma-assisted carbon nanotube field-effect transistor (DM-PA-CNTFET) biosensor is proposed for breast cancer detection. This work is based on a PA-CNTFET in which CNT is used as a channel of FET, and various other device engineering techniques such as dual metal gate-all-around structure and dielectric stack of SiO2 and HfO2 have been used. A comparative analysis of DS-GAAE-CNTFET was performed using a silicon gate all-around FET (Silicon-GAA-FET)-based biosensor. Early detection of breast cancer is made possible by immobilizing MDA-MB-231 and HS578t into the dual-sided nanocavity, which alters the electrical properties of the proposed CNTFET-based biosensor. The DS-GAAE-CNTFET sensor demonstrates a drain ON current sensitivity of 236.9 nA and a threshold voltage sensitivity of 285.58 mV for HS578t cancer cells. Malignant MDA-MB-231 breast cells exhibit a higher drain ON current sensitivity of 343.35 nA and a corresponding threshold voltage sensitivity of 293.23 mV. The exceptional sensitivity and structural resilience of the DS-GAAE-CNTFET biosensor establish it as a promising candidate for early breast cancer detection.
{"title":"DM-PA-CNTFET Biosensor for Breast Cancer Detection: Analytical Model","authors":"Bhargavi Sharma, Shivani Yadav, Sonam Rewari, Yasha Hasija","doi":"10.1149/2162-8777/ad6a88","DOIUrl":"https://doi.org/10.1149/2162-8777/ad6a88","url":null,"abstract":"In this paper, an analytical model for a novel design dielectric modulated plasma-assisted carbon nanotube field-effect transistor (DM-PA-CNTFET) biosensor is proposed for breast cancer detection. This work is based on a PA-CNTFET in which CNT is used as a channel of FET, and various other device engineering techniques such as dual metal gate-all-around structure and dielectric stack of SiO<sub>2</sub> and HfO<sub>2</sub> have been used. A comparative analysis of DS-GAAE-CNTFET was performed using a silicon gate all-around FET (Silicon-GAA-FET)-based biosensor. Early detection of breast cancer is made possible by immobilizing MDA-MB-231 and HS578t into the dual-sided nanocavity, which alters the electrical properties of the proposed CNTFET-based biosensor. The DS-GAAE-CNTFET sensor demonstrates a drain ON current sensitivity of 236.9 nA and a threshold voltage sensitivity of 285.58 mV for HS578t cancer cells. Malignant MDA-MB-231 breast cells exhibit a higher drain ON current sensitivity of 343.35 nA and a corresponding threshold voltage sensitivity of 293.23 mV. The exceptional sensitivity and structural resilience of the DS-GAAE-CNTFET biosensor establish it as a promising candidate for early breast cancer detection.","PeriodicalId":11496,"journal":{"name":"ECS Journal of Solid State Science and Technology","volume":"67 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-13DOI: 10.1149/2162-8777/ad6a89
Shwetapadma Panda, Sidhartha Dash
A dual-source cavity charge plasma tunneling FET (DSC-SP-CPTFET) with SiGe Pocket is proposed, and its effectiveness as a biological sensor for label-free detection is explored. The fabrication complexity and cost have been reduced by using the charge-plasma concept. For improved sensing, an etched nanocavity is added to the upper and lower of the source metal section. The high-k (HfO2) gate oxide and minimal energy gap (Si0.6Ge0.4) alloy with a 40% mole fraction improve the current sensitivity by enhancing the drain current gradient. The sensitivity of the suggested biological sensor is assessed here for several neutral biological molecules, such as Gelatin, Keratin, Biotin, and 3-Aminopropyl-Triethoxysilane (APTES). Deoxyribonucleic acid (DNA), a charged biological molecule, is also considered with varying positive and negative charge densities. The suggested biological sensor shows a (SIDS)max of 2.21 × 1010 and a Sratio of 3.11 × 109 for biological molecules with higher dielectric constant at room temperature. Different electrostatic performances are estimated in the ON state, including energy band, electron (e-) BTBT rate, electrical field, and IDS-VGS characteristics. In addition, the proposed biological sensor provides a much superior drain current sensitivity (SIDS), current ratio sensitivity (Sratio), and average SS sensitivity (SSS) performance in the presence of both charged and neutral biological molecules.
{"title":"Modeling and Sensitivity Estimation of a Dual Cavity Source Pocket-Based Charge Plasma Tunneling FET for Label-Free Biological Molecule Detection","authors":"Shwetapadma Panda, Sidhartha Dash","doi":"10.1149/2162-8777/ad6a89","DOIUrl":"https://doi.org/10.1149/2162-8777/ad6a89","url":null,"abstract":"A dual-source cavity charge plasma tunneling FET (DSC-SP-CPTFET) with SiGe Pocket is proposed, and its effectiveness as a biological sensor for label-free detection is explored. The fabrication complexity and cost have been reduced by using the charge-plasma concept. For improved sensing, an etched nanocavity is added to the upper and lower of the source metal section. The high-<italic toggle=\"yes\">k</italic> (HfO<sub>2</sub>) gate oxide and minimal energy gap (Si<sub>0.6</sub>Ge<sub>0.4</sub>) alloy with a 40% mole fraction improve the current sensitivity by enhancing the drain current gradient. The sensitivity of the suggested biological sensor is assessed here for several neutral biological molecules, such as Gelatin, Keratin, Biotin, and 3-Aminopropyl-Triethoxysilane (APTES). Deoxyribonucleic acid (DNA), a charged biological molecule, is also considered with varying positive and negative charge densities. The suggested biological sensor shows a (S<sub>IDS</sub>)<sub>max</sub> of 2.21 × 10<sup>10</sup> and a S<sub>ratio</sub> of 3.11 × 10<sup>9</sup> for biological molecules with higher dielectric constant at room temperature. Different electrostatic performances are estimated in the ON state, including energy band, electron (e<sup>-</sup>) BTBT rate, electrical field, and I<sub>DS</sub>-V<sub>GS</sub> characteristics. In addition, the proposed biological sensor provides a much superior drain current sensitivity (S<sub>IDS</sub>), current ratio sensitivity (S<sub>ratio</sub>), and average SS sensitivity (S<sub>SS</sub>) performance in the presence of both charged and neutral biological molecules.","PeriodicalId":11496,"journal":{"name":"ECS Journal of Solid State Science and Technology","volume":"14 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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