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Lineages and sublineages of human papillomavirus type 16 in cervical samples of Iranian women 伊朗妇女宫颈样本中人乳头瘤病毒16型的谱系和亚系
IF 3.1 4区 医学 Q3 Immunology and Microbiology Pub Date : 2023-04-17 DOI: 10.2217/fvl-2022-0174
Mostafa Salehi-Vaziri, Farzin Sadeghi, H. Haeri, F. Bokharaei-Salim, S. Monavari, F. Hashemi, S. Jalilvand, H. Keyvani
Aim: This study was designed to analyze intratypic variations of human papillomavirus type 16 (HPV16) and to assess the risk of these variants for progression to cervical cancer. Materials & Methods: HPV16 variants of 58 women were determined by PCR-directed sequencing. Results: The most frequent lineage was D (67.2%) followed by A (32.8%). Lineage A was found predominantly in normal (62.5%) and cervical intraepithelial neoplasia-1 (CIN-1) (83.3%), while lineage D was the most prevalent variant in cervical cancer (100%). Conclusion: The present study revealed a distinct pattern of HPV16 variants in Iran. Based on our data, the predominant HPV16 lineage was D and there was a significant association between lineage D variants and cervical cancer.
目的:本研究旨在分析人乳头瘤病毒16型(HPV16)的型内变异,并评估这些变异发展为癌症的风险。材料与方法:采用聚合酶链式反应直接测序法对58例女性HPV16变异株进行检测。结果:最常见的谱系是D(67.2%),其次是A(32.8%)。A谱系主要出现在正常(62.5%)和宫颈上皮内瘤样病变-1(CIN-1)(83.3%)中,而D谱系是癌症最常见的变体(100%)。结论:本研究揭示了伊朗HPV16变异的独特模式。根据我们的数据,主要的HPV16谱系是D,并且谱系D变异与宫颈癌症之间存在显著关联。
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引用次数: 0
The involvement of NLRP3 inflammasome in herpes simplex virus infection and treatment NLRP3炎性体参与单纯疱疹病毒感染及治疗
IF 3.1 4区 医学 Q3 Immunology and Microbiology Pub Date : 2023-04-14 DOI: 10.2217/fvl-2023-0031
Yuan Ding, Haifeng Yu, Liqiong Ding
Herpes simplex virus (HSV) can cause life-threatening diseases such as herpes simplex keratitis and herpes simplex encephalitis, with considerable tissue damage resulting from viral replication. The immune response that is activated in response to infection to control viral replication may become exaggerated and contribute to this damage. An overactive inflammatory response could be controlled using immunomodulatory strategies, an ideal target for which may be the multiple pattern recognition receptors that are involved in the innate immune response to HSV, including Toll-like receptors, RIG-I-like receptors, nucleotide oligomerization domain like receptors and cGAS-STING. Here, we summarize the role of the NLRP3 inflammasome in HSV infection and discuss the potential mechanism and therapeutic strategies of targeting the NLRP3 inflammasome for HSV-related diseases.
单纯疱疹病毒(HSV)可导致危及生命的疾病,如单纯疱疹角膜炎和单纯疱疹脑炎,病毒复制会对组织造成相当大的损伤。在感染时被激活以控制病毒复制的免疫反应可能会被夸大,并导致这种损伤。过度活跃的炎症反应可以使用免疫调节策略来控制,其理想靶点可能是参与对HSV的先天免疫反应的多种模式识别受体,包括Toll样受体、RIG-I样受体、核苷酸寡聚结构域样受体和cGAS-STING。在此,我们总结了NLRP3炎症小体在HSV感染中的作用,并讨论了靶向NLRP3炎性小体治疗HSV相关疾病的潜在机制和治疗策略。
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引用次数: 0
Higher viral load of BK polyomavirus in urothelial bladder tumors compared with nontumoral bladder tissues 与非肿瘤膀胱组织相比,尿路上皮膀胱肿瘤中BK多瘤病毒的病毒载量更高
IF 3.1 4区 医学 Q3 Immunology and Microbiology Pub Date : 2023-04-14 DOI: 10.2217/fvl-2023-0025
H. Kamalinia, Talieh Mostaghimi, Mahdie Taheri, Moein Shirzad, A. A. Pasha, Y. Yahyapour, E. Moudi, Farzin Sadeghi
Aim: This study examined BK polyomavirus (BKPyV) genome and viral load in urothelial bladder carcinoma (UBC) and nontumoral bladder tissues. Materials & methods: Quantitative real-time PCR was used to measure viral LT-Ag copy number per cell in 114 fresh-frozen bladder biopsy samples (61 UBC and 53 nontumoral tissue samples). Results: Patients with UBC had a significantly higher mean BKPyV LT-Ag DNA load than those without UBC. In multivariate logistic regression analysis, BKPyV LT-Ag copies/cell and smoking/illicit use of drugs were associated with bladder cancer. Receiver operating characteristic curve analysis identified bladder cancer risk at 0.1 copies/cell. Conclusion: This study found high BKPyV LT-Ag DNA copy numbers in most UBC samples, supporting the hypothesis that BKPyV induces UBC tumorigenesis.
目的:本研究检测BK多瘤病毒(BKPyV)基因组和尿路上皮膀胱癌(UBC)及非肿瘤膀胱组织中的病毒载量。材料与方法:采用实时定量聚合酶链式反应测定114份新鲜冷冻膀胱活检样本(61份UBC和53份非肿瘤组织样本)中每个细胞的病毒LT-Ag拷贝数。结果:UBC患者的BKPyV LT-Ag DNA平均载量显著高于无UBC患者。在多变量逻辑回归分析中,BKPyV LT-Ag拷贝数/细胞和吸烟/非法使用药物与癌症相关。受试者操作特征曲线分析确定了0.1拷贝/细胞的膀胱癌症风险。结论:本研究在大多数UBC样本中发现了高BKPyV LT-Ag DNA拷贝数,支持了BKPyV诱导UBC肿瘤发生的假说。
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引用次数: 0
In silico assessment of diterpenes as potential inhibitors of SARS-COV-2 main protease. 二萜作为SARS-COV-2主要蛋白酶潜在抑制剂的计算机模拟评估
IF 3.1 4区 医学 Q3 Immunology and Microbiology Pub Date : 2023-04-01 Epub Date: 2023-05-22 DOI: 10.2217/fvl-2022-0163
Yousef A Abdelrady, Naeem Mahmood Ashraf, Arslan Hamid, Hayam S Thabet, Asmaa M Sayed, Shimaa H Salem, Emad Hm Hassanein, Ahmed M Sayed

Aim: We aimed to investigate the potential inhibitory effects of diterpenes on SARS-CoV-2 main protease (Mpro).

Materials & methods: We performed a virtual screening of diterpenoids against Mpro using molecular docking, molecular dynamics simulation and absorption, distribution, metabolism and excretion) analysis.

Results: Some tested compounds followed Lipinski's rule and showed drug-like properties. Some diterpenoids possessed remarkable binding affinities with SARS-CoV-2 Mpro and drug-like pharmacokinetic properties. Three derivatives exhibited structural deviations lower than 1 Å.

Conclusion: The findings of the study suggest that some of the diterpenes could be candidates as potential inhibitors for Mpro of SARS-CoV-2.

目的:探讨二萜对SARS-CoV-2主蛋白酶(Mpro)的潜在抑制作用。材料与方法:采用分子对接、分子动力学模拟和吸收、分布、代谢和排泄分析等方法对抗Mpro二萜类化合物进行虚拟筛选。结果:一些被测化合物遵循利平斯基规则并表现出类似药物的性质。某些二萜类化合物与SARS-CoV-2 Mpro具有显著的结合亲和力和药物样药代动力学特性。三个衍生物的结构偏差均小于1 Å。结论:研究结果提示,部分二萜可能是SARS-CoV-2 Mpro的潜在抑制剂。
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引用次数: 0
Effects of COVID-19 and vaccination on the human immune system: cases of lymphopenia and autoimmunity 新冠肺炎和疫苗接种对人体免疫系统的影响:淋巴细胞减少和自身免疫病例
IF 3.1 4区 医学 Q3 Immunology and Microbiology Pub Date : 2023-04-01 DOI: 10.2217/fvl-2022-0218
Joachim Gerlach, A. Baig
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引用次数: 0
Conference proceedings from hybrid 25th Bangkok International Symposium on HIV Medicine 第25届曼谷艾滋病毒医学国际混合研讨会会议记录
IF 3.1 4区 医学 Q3 Immunology and Microbiology Pub Date : 2023-03-28 DOI: 10.2217/fvl-2023-0019
P. Ohata, A. Avihingsanon, Siwat Thammapiwan, W. M. Han, Akarin Hiransuthikul, Hay Mar Su Lwin, S. Ubolyam, Jedsadakorn Boonrungsirisap, S. Kerr, S. Gatechompol, T. Puthanakit, O. Putcharoen, K. Ruxrungtham, P. Phanuphak
The Bangkok International Symposium on HIV Medicine has commenced on the 3rd Wednesday in January since 1998. The Symposium aims to provide professional healthcare workers in Thailand and the region an opportunity to receive the most up-to-date information on HIV and its related conditions if they are unable to attend other HIV conferences abroad. This year’s hybrid symposium was held from 18 January to 20 January 2023. A total of six plenary sessions were held in the mornings, and four afternoon workshops held on Wednesday and Thursday. Expert speakers from Thailand, China, Malaysia, Singapore, India, Hong Kong, Philippines, Australia, UK, The Netherlands and the USA participated in the symposium.
自1998年以来,曼谷艾滋病毒医学国际研讨会于每年1月的第3个星期三开始。研讨会旨在为泰国和该地区的专业医护人员提供一个机会,如果他们无法参加国外的其他艾滋病毒会议,就可以获得有关艾滋病毒及其相关病症的最新信息。今年的混合研讨会于2023年1月18日至1月20日举行。上午共举行了六次全体会议,星期三和星期四下午举行了四次讲习班。来自泰国、中国、马来西亚、新加坡、印度、香港、菲律宾、澳大利亚、英国、荷兰和美国的专家演讲者参加了研讨会。
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引用次数: 0
RT-LAMP is a potential future molecular diagnostic tool for influenza A virus RT-LAMP是一种潜在的a型流感病毒分子诊断工具
IF 3.1 4区 医学 Q3 Immunology and Microbiology Pub Date : 2023-03-15 DOI: 10.2217/fvl-2022-0136
Sanjit Boora, Anishkumar Khan, Vikrant Sharma, S. Kaushik, P. Mehta, S. Singh, S. Kaushik
Aim: Influenza A virus (IAV) causes serious illness and is responsible for significant morbidity and mortality. To diagnose IAV infection in its early stages, a quick, sensitive, precise detection method is needed for effective clinical management. Materials & methods: In-house hydroxylnaphthol blue (HNB)-based RT-LAMP assay for early detection of IAV using the HA gene was compared with RT-PCR/multiplex-RT-PCR. Results: For the reference strains of IAV, (H1N1 (A/Texas/50/2012) and H3N2 (A/Malaysia/2089302/2009)) RT-LAMP and RT-PCR/M-RT-PCR exhibited a limit of detection (LOD) of 10 and 100 fg/ml, respectively. Conclusion: HNB-based RT-LAMP is a rapid, sensitive, cost-effective diagnostic tool, and could be a point-of-care test for IAV patients during outbreaks.
目的:甲型流感病毒(IAV)引起严重疾病,并导致严重的发病率和死亡率。为了在早期诊断IAV感染,需要一种快速、灵敏、精确的检测方法来进行有效的临床管理。材料与方法:将基于HNB的HA基因RT-LAMP室内早期检测IAV的方法与RT-PCR/多重RT-PCR进行比较。结果:对于IAV的参考菌株(H1N1(A/Texas/50/2012)和H3N2(A/Malaysia/2089302/2009)),RT-LAMP和RT-RTP/M-RTP分别显示出10和100fg/ml的检测限(LOD)。结论:基于HNB的RT-LAMP是一种快速、灵敏、成本效益高的诊断工具,可以作为IAV患者在疫情期间的护理点测试。
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引用次数: 4
Potential roles of core and core+1 proteins during the chronic phase of hepatitis C virus infection 核心蛋白和核心+1蛋白在丙型肝炎病毒感染慢性期的潜在作用
IF 3.1 4区 医学 Q3 Immunology and Microbiology Pub Date : 2023-03-14 DOI: 10.2217/fvl-2022-0117
Asra Malekshahi, A. Alamdary, Ali Safarzadeh, A. Khavandegar, H. R. Nikoo, Mahshid Safavi, Mobina Ajorloo, Atefeh Bahavar, Mehdi Ajorloo
The HCV Core protein is a multifunctional protein that interacts with many viral and cellular proteins. In addition to the encapsidation of the viral genome, it can disturb various cellular pathways and impede antiviral cellular responses such as interferon (IFN) production. The Core protein can also disrupt the functions of immune cells against HCV. The Core protein helps viral infection persistency by interfering with apoptosis. The Core+1 protein plays a significant role in inducing chronic HCV infection through diverse mechanisms. We review some of the mechanisms by which Core and Core+1 proteins facilitate HCV infection to chronic infection. These proteins could be considered for designing more sufficient treatments and effective vaccines against HCV.
HCV核心蛋白是一种多功能蛋白,与许多病毒和细胞蛋白相互作用。除了病毒基因组的外壳外,它还可以干扰各种细胞途径,阻碍抗病毒细胞反应,如干扰素(IFN)的产生。核心蛋白还可以破坏免疫细胞对抗丙型肝炎病毒的功能。核心蛋白通过干扰细胞凋亡来帮助病毒感染的持续性。核心+1蛋白通过多种机制在诱导慢性丙型肝炎病毒感染中发挥着重要作用。我们综述了核心蛋白和核心+1蛋白促进丙型肝炎病毒感染转变为慢性感染的一些机制。这些蛋白质可用于设计更充分的治疗方法和有效的HCV疫苗。
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引用次数: 0
Nanocarrier-based drug delivery system in herpes simplex virus treatment 纳米载体给药系统在单纯疱疹病毒治疗中的应用
IF 3.1 4区 医学 Q3 Immunology and Microbiology Pub Date : 2023-03-09 DOI: 10.2217/fvl-2022-0171
W. Yin, Liqiong Ding
Herpes simplex virus (HSV) is a highly contagious DNA virus that affects the majority of people worldwide. HSV establishes a latent infection in the ganglia, where it can reactivate, leading to recurrent disease. Currently, there are many experimental vaccines against HSV, but none have been used to treat herpes infections. At the same time, the therapeutic effect of existing anti-HSV drugs is limited. Nanocarriers, which deliver drugs to specific targets, have been used in different diseases, including viral infections. Nanocarriers could be designed to encapsulate drugs and directly target infected cells. This review will describe in detail the use of nanocarriers for targeted therapy of HSV infection.
单纯疱疹病毒(HSV)是一种高度传染性的DNA病毒,影响着全世界大多数人。HSV在神经节中建立了一种潜在的感染,在那里它可以重新激活,导致疾病复发。目前,有许多针对HSV的实验性疫苗,但没有一种用于治疗疱疹感染。同时,现有抗HSV药物的治疗效果有限。将药物输送到特定靶点的纳米载体已被用于不同的疾病,包括病毒感染。纳米载体可以被设计成封装药物并直接靶向受感染的细胞。这篇综述将详细描述纳米载体在HSV感染靶向治疗中的应用。
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引用次数: 0
Epidemiological and clinical features of human rabies in Dazu District, Chongqing, China from 2014 to 2021 2014 - 2021年重庆市大足区人狂犬病流行病学及临床特征
IF 3.1 4区 医学 Q3 Immunology and Microbiology Pub Date : 2023-03-06 DOI: 10.2217/fvl-2022-0149
Wan Shi-Gang, Liu He-Lei, Xia Hong, Wu Jing
The epidemiological and clinical data of human rabies cases in the Dazu District of Chongqing from 2014 to 2021 were analyzed retrospectively to determine the epidemiological and clinical features of human rabies cases in Chonqing, China. Nine cases were reported. All cases occurred in farmers from rural areas associated with lower rabies awareness, and eight cases had a definitive history of animal exposure, most commonly in the form of domestic dog bites. All nine patients presented as manic and died within 1–8 days from disease onset (mortality rate of 100%). Increased public awareness of rabies prevention and control is needed, especially among middle-aged and elderly populations in rural areas.
对重庆市大足区2014~2021年狂犬病病例的流行病学和临床资料进行回顾性分析,以确定重庆市狂犬病病例的流行和临床特征。报告了9例病例。所有病例都发生在农村地区的农民中,他们对狂犬病的认识较低,其中8例有明确的动物接触史,最常见的是家狗咬伤。所有9名患者均表现为躁狂,并在发病后1-8天内死亡(死亡率为100%)。需要提高公众对狂犬病预防和控制的认识,特别是在农村地区的中老年人群中。
{"title":"Epidemiological and clinical features of human rabies in Dazu District, Chongqing, China from 2014 to 2021","authors":"Wan Shi-Gang, Liu He-Lei, Xia Hong, Wu Jing","doi":"10.2217/fvl-2022-0149","DOIUrl":"https://doi.org/10.2217/fvl-2022-0149","url":null,"abstract":"The epidemiological and clinical data of human rabies cases in the Dazu District of Chongqing from 2014 to 2021 were analyzed retrospectively to determine the epidemiological and clinical features of human rabies cases in Chonqing, China. Nine cases were reported. All cases occurred in farmers from rural areas associated with lower rabies awareness, and eight cases had a definitive history of animal exposure, most commonly in the form of domestic dog bites. All nine patients presented as manic and died within 1–8 days from disease onset (mortality rate of 100%). Increased public awareness of rabies prevention and control is needed, especially among middle-aged and elderly populations in rural areas.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49236943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Future Virology
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