Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-308-310
E. Zvereva, O. Hendriсkson, D. Popravko, B. Dzantiev
Immunochromatographic test systems with rapid sample preparation have been developed for testing the composition of meat products, which ensure the identification and assessment of the content of muscle tissues from different groups of animals. It was shown that the technological processes of enzymatic and heat treatment did not impair the selective detection of biomarkers.
{"title":"DEVELOPMENT OF IMMUNOCHEMICAL SYSTEMS TO CONTROL AUTHENTICITY AND COMPOSITION OF MEAT PRODUCTS","authors":"E. Zvereva, O. Hendriсkson, D. Popravko, B. Dzantiev","doi":"10.37747/2312-640x-2021-19-308-310","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-308-310","url":null,"abstract":"Immunochromatographic test systems with rapid sample preparation have been developed for testing the composition of meat products, which ensure the identification and assessment of the content of muscle tissues from different groups of animals. It was shown that the technological processes of enzymatic and heat treatment did not impair the selective detection of biomarkers.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87742041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-139-140
S.E. Tarbeeva, A. V. Lisitsa, E. Ponomarenko
Information about the trends in studies of molecular profiles of healthy people has been obtained.
获得了有关健康人分子谱研究趋势的信息。
{"title":"MOLECULAR PROFILE OF A HEALTHY PERSON – MODERN RESEARCH TRENDS","authors":"S.E. Tarbeeva, A. V. Lisitsa, E. Ponomarenko","doi":"10.37747/2312-640x-2021-19-139-140","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-139-140","url":null,"abstract":"Information about the trends in studies of molecular profiles of healthy people has been obtained.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"154 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88141083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-365-367
E. Semenova, L. Teplitskaya, G. Zaitsev, I. Tsokalo, A. Omelchenko, I. Bugara
The efficiency of the consortium of lactic oxide bacteria and yeast is shown to suppress phytophotogenic bacteria and micromicets, conditionally pathogenic bacteria in vitro conditions. It has been shown that 1.0% of the solution of the culture fluid of the microbial consortium has the maximum effect in reducing the infestation of seed cereals.
{"title":"ANTAGONISTIC EFFECT OF MONOCULTURES OF MILK-OXIDE BACTERIA AND THEIR CONSORTIUM WITH YEASTS ON PATHOGENIC BACTERIA AND FUNGI","authors":"E. Semenova, L. Teplitskaya, G. Zaitsev, I. Tsokalo, A. Omelchenko, I. Bugara","doi":"10.37747/2312-640x-2021-19-365-367","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-365-367","url":null,"abstract":"The efficiency of the consortium of lactic oxide bacteria and yeast is shown to suppress phytophotogenic bacteria and micromicets, conditionally pathogenic bacteria in vitro conditions. It has been shown that 1.0% of the solution of the culture fluid of the microbial consortium has the maximum effect in reducing the infestation of seed cereals.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"30 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85939593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-250-252
G. Lomakina
Bioluminescent methods based on firefly luciferase for detecting the effect of membrane-active agents (antibiotics and saponins) on living prokaryotic and eukaryotic cells have been developed. New data on the kinetics and mechanism of action of colistin on E. coli cells and digitonin cells on NEK293 cells were obtained. Examples of the use of constitutive and inducible luciferase reporters in cell biology are given.
{"title":"APPLICATION OF BIOLUMINESCENT METHODS TO STUDY STRESS EFFECTS ON LIVING SYSTEMS","authors":"G. Lomakina","doi":"10.37747/2312-640x-2021-19-250-252","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-250-252","url":null,"abstract":"Bioluminescent methods based on firefly luciferase for detecting the effect of membrane-active agents (antibiotics and saponins) on living prokaryotic and eukaryotic cells have been developed. New data on the kinetics and mechanism of action of colistin on E. coli cells and digitonin cells on NEK293 cells were obtained. Examples of the use of constitutive and inducible luciferase reporters in cell biology are given.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85079987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-294-297
E. Faizulina, S. Aitkeldiyeva, L. Tatarkina, B. Baimakhanova, G. Spankulova
The ability of consortia of thermotolerant oil-oxidizing microorganisms to utilize oil at elevated temperatures has been studied. At 35°C the degree of oil destruction was 55-87.3%, at 40°C - 54.8-64.3%, at 50°C - 55-73.2%.
{"title":"CONSORTIA OF THERMOTOLERANT OIL-OXIDIZING MICROORGANISMS CAPABLE OF EFFICIENTLY DECOMPOSING OIL","authors":"E. Faizulina, S. Aitkeldiyeva, L. Tatarkina, B. Baimakhanova, G. Spankulova","doi":"10.37747/2312-640x-2021-19-294-297","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-294-297","url":null,"abstract":"The ability of consortia of thermotolerant oil-oxidizing microorganisms to utilize oil at elevated temperatures has been studied. At 35°C the degree of oil destruction was 55-87.3%, at 40°C - 54.8-64.3%, at 50°C - 55-73.2%.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91210333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-130-132
Approachability and high quality of the information on bio-samples in biobanks is a function for the efficient research work. The web-repository of biological samples "Vitrina" provides an opportunity for direct communication between researcher and the holder of the biobank.
{"title":"«SHOWCASE» OF BIOSPECIMEN: METHOD OF COMMUNICATION BETWEEN RESEARCHER AND BIOBANK HOLDER","authors":"","doi":"10.37747/2312-640x-2021-19-130-132","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-130-132","url":null,"abstract":"Approachability and high quality of the information on bio-samples in biobanks is a function for the efficient research work. The web-repository of biological samples \"Vitrina\" provides an opportunity for direct communication between researcher and the holder of the biobank.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91416272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-209-211
D. Druzhilovskiy, P. Savosina, O. Gomazkov, B. Sobolev, A. Veselovsky, O. Tarasova, N. Biziukova, N. Ionov, S. Ivanov, A. Rudik, L. Stolbov, P. Pogodin, D. Karasev, D.A. Dmitriev, A. Lagunin, D. Filimonov
Drug repositioning – the discovery of new indications for the launched drugs – is the rapid natural response to viral infection SARS-CoV-2/COVID-19. We will consider the current state of research and development of repositioned pharmaceuticals for the therapy of COVID-19 using in silico and in vitro methods.
{"title":"DRUG REPOSITIONING FOR THERAPY OF COVID-19","authors":"D. Druzhilovskiy, P. Savosina, O. Gomazkov, B. Sobolev, A. Veselovsky, O. Tarasova, N. Biziukova, N. Ionov, S. Ivanov, A. Rudik, L. Stolbov, P. Pogodin, D. Karasev, D.A. Dmitriev, A. Lagunin, D. Filimonov","doi":"10.37747/2312-640x-2021-19-209-211","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-209-211","url":null,"abstract":"Drug repositioning – the discovery of new indications for the launched drugs – is the rapid natural response to viral infection SARS-CoV-2/COVID-19. We will consider the current state of research and development of repositioned pharmaceuticals for the therapy of COVID-19 using in silico and in vitro methods.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88474940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-77-79
D. Zhdanov, N. Sokolov, E. Kudryashova
Covalent conjugates of asparaginase with copolymers of chitosan-PEG, chitosan-glycol and chitosan-PEI were obtained and their antitumor activity on human chronic myeloma leukemia K-562 cells was determined.
{"title":"REGULATION OF BIOCATALYTIC PROPERTIES OF RHODOSPIRILLUM RUBRUM L-ASPARAGINASE BY THE FORMATION OF ENZYME CONJUGATES WITH POLYCATIONS","authors":"D. Zhdanov, N. Sokolov, E. Kudryashova","doi":"10.37747/2312-640x-2021-19-77-79","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-77-79","url":null,"abstract":"Covalent conjugates of asparaginase with copolymers of chitosan-PEG, chitosan-glycol and chitosan-PEI were obtained and their antitumor activity on human chronic myeloma leukemia K-562 cells was determined.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84735158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-82-84
D. Baidamshina, M. Holyavka, E. Trizna, Koroleva V.A., S.M. Olshannikova
The successful destruction of biofilm structures and the significant decrease of non-specific bacterial adhesion to the surfaces after either Ficin or Papain treatment have been detected. The combination of enzymes with antimicrobials increased the efficacy of the latter against biofilm-embedded bacteria. Moreover, Ficin treatment lead to smoother reepithelisation, and new tissue formation exhibiting collagen structure characteristics closely reminiscent of those observed in the native tissue. Thus, both soluble and immobilized Ficin and Papain appear beneficial for the treatment of biofilm-associated infections, speeding up wound healing and microbial decontamination.
{"title":"THE USE OF HYDROLYTIC ENZYMES TO INCREASE THE EFFICIENCY OF THERAPY OF INFECTIONS ASSOCIATED\u0000WITH THE FORMATION OF BACTERIAL BIOFILM","authors":"D. Baidamshina, M. Holyavka, E. Trizna, Koroleva V.A., S.M. Olshannikova","doi":"10.37747/2312-640x-2021-19-82-84","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-82-84","url":null,"abstract":"The successful destruction of biofilm structures and the significant decrease of non-specific bacterial adhesion to the surfaces after either Ficin or Papain treatment have been detected. The combination of enzymes with antimicrobials increased the efficacy of the latter against biofilm-embedded bacteria. Moreover, Ficin treatment lead to smoother reepithelisation, and new tissue formation exhibiting collagen structure characteristics closely reminiscent of those observed in the native tissue. Thus, both soluble and immobilized Ficin and Papain appear beneficial for the treatment of biofilm-associated infections, speeding up wound healing and microbial decontamination.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83233118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-320-322
L. Rimareva, P.Yu. Tadjibova, N. Pogorzhelskaya, N. Ignatova, M. Overchenko
Comparative studies of biotechnological methods for obtaining fermented products based on the conversion of soy raw materials with a selected complex of endogenous enzymes and using a selected strain of Aspergillus oryzae - the producer of a complex of proteases and other hydrolases.
{"title":"FEATURES OF THE BIOCONVERSION OF SOY RAW MATERIALS INTO FERMENTED PRODUCTS","authors":"L. Rimareva, P.Yu. Tadjibova, N. Pogorzhelskaya, N. Ignatova, M. Overchenko","doi":"10.37747/2312-640x-2021-19-320-322","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-320-322","url":null,"abstract":"Comparative studies of biotechnological methods for obtaining fermented products based on the conversion of soy raw materials with a selected complex of endogenous enzymes and using a selected strain of Aspergillus oryzae - the producer of a complex of proteases and other hydrolases.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79915255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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