Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-73-75
B. Kurganov
Bioconjugate Ag‧PE was obtained by the synthesis of silver nanoparticles in the phycoerythrin tunnel cavity without an exogenous reducing agent. Physicochemical properties of the conjugate and analysis of published data indicate that Ag‧PE can find application for diagnostics and therapy (theranostics) of cancer, as well as fluorescent biosensors and electrochemical biointerfaces.
{"title":"BIOCONJUGATE OF R-PHYCOERYTHRIN WITH AG0 NANOPARTICLE – FUNCTIONAL NANOSTRUCTURE FOR CANCER THERANOSTICS, FLUORESCENT BIOSENSORS AND ELECTROCHEMICAL BIOINTERFACES","authors":"B. Kurganov","doi":"10.37747/2312-640x-2021-19-73-75","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-73-75","url":null,"abstract":"Bioconjugate Ag‧PE was obtained by the synthesis of silver nanoparticles in the phycoerythrin tunnel cavity without an exogenous reducing agent. Physicochemical properties of the conjugate and analysis of published data indicate that Ag‧PE can find application for diagnostics and therapy (theranostics) of cancer, as well as fluorescent biosensors and electrochemical biointerfaces.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75783708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-269-271
A. Aslanli, I. Lyagin
The conducted studies made it possible to identify new targets in the form of the most important decarboxylases for the possible negative effects of known organophosphorus compounds and to assess their potential danger to humans.
{"title":"ENZYMES AS TARGETS FOR THE EFFECTS OF ORGANOPHOSPHORUS COMPOUNDS AND THEIR BIOCATALYTIC DETOXIFIERS: A NEW LOOK AT A WELL-KNOWN PROBLEM","authors":"A. Aslanli, I. Lyagin","doi":"10.37747/2312-640x-2021-19-269-271","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-269-271","url":null,"abstract":"The conducted studies made it possible to identify new targets in the form of the most important decarboxylases for the possible negative effects of known organophosphorus compounds and to assess their potential danger to humans.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"2012 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78914584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-178-179
A. Potekhina, P. Alexyuk, I. Zaitseva, N. Sokolova, E.S. Omirtayeva, M. Alexyuk, A. P. Bogoyavlenskiy, V. Berezin
The ability of the Auricularia auricular-judae extract to suppress the reproduction of the influenza virus was studied. It was shown that the index of the therapeutic activity of the extract is comparable to that of commercial preparations Tamiflu and Remantadine.
{"title":"ABILITY OF AURICULARIA AURICULAR-JUDAE EXTRACT TO SUPPRESS INFLUENZA VIRUS REPRODUCTION","authors":"A. Potekhina, P. Alexyuk, I. Zaitseva, N. Sokolova, E.S. Omirtayeva, M. Alexyuk, A. P. Bogoyavlenskiy, V. Berezin","doi":"10.37747/2312-640x-2021-19-178-179","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-178-179","url":null,"abstract":"The ability of the Auricularia auricular-judae extract to suppress the reproduction of the influenza virus was studied. It was shown that the index of the therapeutic activity of the extract is comparable to that of commercial preparations Tamiflu and Remantadine.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"149 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74765473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-304-306
I. I. Grigorevskaya, E. Yushina
The use of the preparation from the biomass of the micromycete Mortierella polycephala provides an increase in the reliability of protection of fruits from microbial spoilage and an increase in the shelf life of fruits.
{"title":"APPLICATION OF THE PREPARATION FROM MICROSCOPIC FUNGI IN THE TECHNOLOGY OF FRUIT PROCESSING BEFORE LAYING FOR STORAGE","authors":"I. I. Grigorevskaya, E. Yushina","doi":"10.37747/2312-640x-2021-19-304-306","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-304-306","url":null,"abstract":"The use of the preparation from the biomass of the micromycete Mortierella polycephala provides an increase in the reliability of protection of fruits from microbial spoilage and an increase in the shelf life of fruits.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83772254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-122-123
T. I. Mulashkina, A. Kulakova
The mechanism of hydrolysis of organophosphates, dibutyl-4-nitro-phenylphosphate and its analogue with an inactivated leaving group – dibutylphenylphosphate by phosphotriesterase Pd-PTE has been determined.
{"title":"STRUCTURAL FEATURES OF PHOSPHOTRIESTERASES HYDROLYZING ORGANOPHOSPHATES WITH AN INACTIVATED LEAVING GROUP","authors":"T. I. Mulashkina, A. Kulakova","doi":"10.37747/2312-640x-2021-19-122-123","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-122-123","url":null,"abstract":"The mechanism of hydrolysis of organophosphates, dibutyl-4-nitro-phenylphosphate and its analogue with an inactivated leaving group – dibutylphenylphosphate by phosphotriesterase Pd-PTE has been determined.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89435808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-149-150
A. Kuzikov, A. Veselovsky, I. Toropygin, A. Archakov, V. Shumyantseva
Interactions of abiraterone and galeterone with steroid-metabolizing cytochrome P450 (CYP51A1) was studied. Binding of substrate type was observed, which indicates possible metabolism of abiraterone and galeterone by CYP51A1, however electrocatalytic reaction only towards abiraterone was observed.
{"title":"INTERACTIONS OF ANTICANCER DRUGS – ABIRATERONE AND GALETERONE – WITH CYTOCHROME P450 51A1 (CYP51A1)","authors":"A. Kuzikov, A. Veselovsky, I. Toropygin, A. Archakov, V. Shumyantseva","doi":"10.37747/2312-640x-2021-19-149-150","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-149-150","url":null,"abstract":"Interactions of abiraterone and galeterone with steroid-metabolizing cytochrome P450 (CYP51A1) was studied. Binding of substrate type was observed, which indicates possible metabolism of abiraterone and galeterone by CYP51A1, however electrocatalytic reaction only towards abiraterone was observed.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75019425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-203-204
A. Klimenko, S. Lashin
The results of our simulations show that motile forms (as opposed to sedentary forms) have an advantage under nutrient-poor conditions corresponding to the environment in which marine bacteria live. There is a turning point in the magnitude of the migration penalty that determines whether the Nomadic strategy will be successful or not.
{"title":"MODELING CHANGES IN THE ADAPTABILITY AND MOTILITY OF MICROORGANISMS IN CHANGING AQUATIC ECOSYSTEMS","authors":"A. Klimenko, S. Lashin","doi":"10.37747/2312-640x-2021-19-203-204","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-203-204","url":null,"abstract":"The results of our simulations show that motile forms (as opposed to sedentary forms) have an advantage under nutrient-poor conditions corresponding to the environment in which marine bacteria live. There is a turning point in the magnitude of the migration penalty that determines whether the Nomadic strategy will be successful or not.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73865423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-16-18
D. Vishnevetskii, A. R. Mekhtiev, S. Khizhnyak, P. Pakhomov
Reversible hydrogels containing silver nanoparticles stabilized by the amino acid L-cysteine in their volume were obtained. The silver salt that initiates gelation - nitrite, nitrate and acetate - affects the bioactive properties of the final material and various possibilities for its modification.
{"title":"AN UNUSUAL SYSTEM BASED ON SULFUR-CONTAINING AMINO ACIDS AND SILVER SALTS: FROM SELF-ORGANIZATION TO APPLICATION PROSPECTS","authors":"D. Vishnevetskii, A. R. Mekhtiev, S. Khizhnyak, P. Pakhomov","doi":"10.37747/2312-640x-2021-19-16-18","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-16-18","url":null,"abstract":"Reversible hydrogels containing silver nanoparticles stabilized by the amino acid L-cysteine in their volume were obtained. The silver salt that initiates gelation - nitrite, nitrate and acetate - affects the bioactive properties of the final material and various possibilities for its modification.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"33 7-8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77653547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-101-104
A. M. Inshakova, E. Darnotuk, A. Shipelova, N. Shastina, O. Baranova, A. Chekanov, K. Kazarinov, E. Solovieva, A. Fedin
Various nanodispersions (liposomes and nanoemulsions) with lipoic acid (LA) with size of particles 50-250 nm were obtained and characterized by 80±10% encapsulation efficiency (EI) of LA into NPs, its slow release from nanoconstructions, and possessing stability during long-term storage at room temperature. It was revealed that liposomes and LA NPs inhibit platelet aggregation caused by arachidonic acid, and the mechanism of antiplatelet action was proposed.
{"title":"NANODISPERSIONS OF LIPOIC ACID: PRODUCTION AND STUDY OF INFLUENCE ON FUNCTIONAL ACTIVITY OF PLATELETS","authors":"A. M. Inshakova, E. Darnotuk, A. Shipelova, N. Shastina, O. Baranova, A. Chekanov, K. Kazarinov, E. Solovieva, A. Fedin","doi":"10.37747/2312-640x-2021-19-101-104","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-101-104","url":null,"abstract":"Various nanodispersions (liposomes and nanoemulsions) with lipoic acid (LA) with size of particles 50-250 nm were obtained and characterized by 80±10% encapsulation efficiency (EI) of LA into NPs, its slow release from nanoconstructions, and possessing stability during long-term storage at room temperature. It was revealed that liposomes and LA NPs inhibit platelet aggregation caused by arachidonic acid, and the mechanism of antiplatelet action was proposed.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77345109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-275-276
N. V. Zavyalova, V. Zavyalov, V. Gorelenkov, G. Frolov, N. Stepanov, A. Aslanli, E. Efremenko
Modern innovative approaches which can be applied to obtain universal protective materials with a wide spectrum of action are analyzed.
分析了可用于获得具有广泛作用谱的通用保护材料的现代创新方法。
{"title":"MODERN BIOCATALYTIC TECHNOLOGIES FOR PROTECTIVE MATERIALS AGAINST BIOLOGICAL AND CHEMICAL AGENTS","authors":"N. V. Zavyalova, V. Zavyalov, V. Gorelenkov, G. Frolov, N. Stepanov, A. Aslanli, E. Efremenko","doi":"10.37747/2312-640x-2021-19-275-276","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-275-276","url":null,"abstract":"Modern innovative approaches which can be applied to obtain universal protective materials with a wide spectrum of action are analyzed.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"38 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78332785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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