International journal of hygiene and environmental health最新文献

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IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2026-01-01

引用次数: 0

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2026-01-01

引用次数: 0

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2026-01-01

引用次数: 0

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2026-01-01

引用次数: 0

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2026-01-01

引用次数: 0

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2026-01-01

引用次数: 0

Perinatal environmental exposures, maternal mental health and cognitive outcomes in very preterm infants born in urban London 围产期环境暴露，孕产妇心理健康和认知结果在伦敦城市出生的极早产儿。

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2025-12-27 DOI: 10.1016/j.ijheh.2025.114740

Zeyuan Sun , Kaili Liang , Andrew Lawrence , Marguerite Leoni , Serena J. Counsell , Paola Dazzan , A David Edwards , Chiara Nosarti

Introduction

Very preterm (VPT) infants face elevated neurodevelopmental risks. The impact of perinatal environmental exposures, where complex factors may affect maternal mental health and infant outcomes, remains poorly understood. This study examines how joint environmental exposures relate to postnatal maternal anxiety and neurodevelopment in VPT infants.

Methods

We included 427 VPT infants born in Greater London (2010–2013). We derived residential environmental exposures: air pollutants, noise, and open space. Clustering analysis identified exposure profiles. At term-equivalent age (38–44 weeks), infants underwent T2-weighted MRI for brain volume and cortical feature analysis. Maternal anxiety, assessed at term; neurodevelopment, evaluated at 18–24 months; and brain development were compared between exposure clusters, adjusting for socioeconomic status (SES). We further explored the role of SES in environmental exposure.

Results

Three exposure profiles emerged. Compared to Group 1 (reference; n = 358), Group 2 (n = 42), characterised by poor air quality and limited open space, had a higher risk of cognitive delay and greater socioeconomic disadvantage. Conversely, Group 3 (n = 27; low noise exposure) exhibited reduced maternal anxiety. SES contributed 20.91 % of the environmental effect on cognitive delay. No significant differences in brain volumes or cortical features were observed.

Conclusion

Perinatal environmental exposures have distinct effects on maternal-infant outcomes. Neurotoxicant exposure and limited access to restorative environments may negatively impact early neurodevelopment, while noise reduction may support maternal mental health. These findings underscore the importance of environmental factors in shaping early development and highlight the need for further research into underlying biological mechanisms and long-term effects.

极早产儿（VPT）面临较高的神经发育风险。围产期环境暴露的影响，其中复杂因素可能影响产妇心理健康和婴儿结局，仍然知之甚少。本研究探讨了联合环境暴露与产后母亲焦虑和VPT婴儿神经发育的关系。方法：我们纳入了2010-2013年在大伦敦出生的427名VPT婴儿。我们得出了住宅环境暴露：空气污染物、噪音和开放空间。聚类分析确定了暴露概况。在足月等龄（38-44周），婴儿接受t2加权MRI检查脑容量和皮质特征分析。产妇焦虑，足月评估；神经发育，18-24个月时评估；在调整社会经济地位（SES）后，比较不同暴露组之间的大脑发育情况。我们进一步探讨了SES在环境暴露中的作用。结果：出现了三种暴露谱。与第1组（参考文献；n = 358）相比，第2组（n = 42）的特点是空气质量差，开放空间有限，认知延迟的风险更高，社会经济劣势更大。相反，第3组（n = 27；低噪音暴露）表现出降低的母亲焦虑。环境因素对认知延迟的影响占20.91%。在脑容量或皮质特征上没有观察到显著差异。结论：围产期环境暴露对母婴结局有明显影响。接触神经毒物和接触恢复性环境的机会有限可能对早期神经发育产生负面影响，而减少噪音可能有助于产妇的心理健康。这些发现强调了环境因素在塑造早期发育中的重要性，并强调了进一步研究潜在生物学机制和长期影响的必要性。

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引用次数: 0

In utero and early childhood exposure to per- and polyfluoroalkyl substances and use of antibiotics in children from the Odense Child Cohort: A Danish cohort study 来自欧登塞儿童队列的儿童在子宫和幼儿期接触全氟烷基和多氟烷基物质以及抗生素的使用：一项丹麦队列研究。

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2025-12-24 DOI: 10.1016/j.ijheh.2025.114734

Nete Lundager Klokker Rausgaard , Lise Gehrt , Martin Thomsen Ernst , Iben Have Beck , Flemming Nielsen , Helene Kildegaard , Anton Pottegård , Tina Kold Jensen , Lars Christian Lund

Background

Per- and polyfluoroalkyl substances (PFAS) have been associated with an increased risk of infectious diseases. We aimed to investigate if in utero and early childhood exposure to PFAS was associated with the number of antibiotic prescriptions up to eight years of age.

Methods

Among 2448 singleton mother-child pairs from the Odense Child Cohort, 1425 had sufficient information on key variables and were included in the primary analysis. Information on redeemed antibiotic prescriptions from birth to eight years of age was obtained from the Danish National Prescription Registry. Longitudinal discrete-time Poisson models were used to quantify the relationship between PFAS and the number of antibiotic prescriptions redeemed. Analyses were carried out separately for PFAS measured in the mother during pregnancy and in the child at 18 months of age. Missing information was imputed using Multiple Imputation by Chained Equations.

Results

We observed no differences in the number of antibiotic prescriptions in the first eight years of life when comparing median and high PFAS concentrations measured in both pregnancy and at 18 months of age (rate ratio PFOA 1.01, 95 % confidence interval 0.94–1.08; PFOS 1.08, 0.98–1.19; PFNA 1.00, 0.94–1.07; PFDA 0.99, 0.94–1.04; PFHxS 1.02, 0.98–1.07).

Conclusion

We found no association between in utero or early childhood PFAS concentrations and number of antibiotic prescriptions up to eight years of age. Antibiotic prescriptions may be an unspecific marker of childhood infections, hampering the possibility to observe an association with PFAS exposure.

Trial registration

Real World Evidence Registry: https://osf.io/dyqxm, registered March 8, 2023.

背景：全氟和多氟烷基物质（PFAS）与传染病风险增加有关。我们的目的是调查在子宫和儿童早期暴露于PFAS是否与8岁前抗生素处方的数量有关。方法：在欧登塞儿童队列的2448对独生子女中，1425对关键变量信息充分，纳入初步分析。从出生到8岁的抗生素处方的信息是从丹麦国家处方登记处获得的。使用纵向离散泊松模型来量化PFAS与抗生素处方赎回数量之间的关系。分别对母亲怀孕期间和孩子18个月时的PFAS进行分析。缺失信息的输入采用链式方程的多重输入。结果：比较妊娠期和18月龄时PFAS中位浓度和高浓度时，我们观察到前8年抗生素处方数量无差异（比率比PFOA 1.01, 95%可信区间0.94-1.08;PFOS 1.08, 0.98-1.19; PFNA 1.00, 0.94-1.07; PFDA 0.99, 0.94-1.04; PFHxS 1.02, 0.98-1.07）。结论：我们没有发现子宫内或儿童早期PFAS浓度与8岁前抗生素处方数量之间的关联。抗生素处方可能是儿童感染的非特异性标记，阻碍了观察与PFAS暴露相关的可能性。试验注册：Real World Evidence Registry: https://osf.io/dyqxm， 2023年3月8日注册。

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引用次数: 0

Association between residential proximity to crop areas and childhood acute leukemia risk in mainland France – GEOCAP case-control study 在法国大陆，居住地靠近种植区与儿童急性白血病风险的关系——GEOCAP病例对照研究

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2025-12-23 DOI: 10.1016/j.ijheh.2025.114737

Matthieu Mancini , Laure Faure , Claire Poulalhon , Aurélie Danjou , Stéphanie Goujon

Background

Pesticide exposures are suspected to be a risk factor for several childhood cancers, particularly acute leukemia (AL) and the most common type, acute lymphoblastic leukemia (ALL). The role of environmental exposures due to agricultural uses of pesticides remains debated.

Objective

The study aimed to investigate whether residential proximity to different crops, used as a proxy for pesticide exposures, is associated with an increased risk of AL in France.

Methods

We included 2731 AL cases diagnosed in 2008–2013 and 28,303 controls representative of the contemporary French pediatric population (1–14 years old), drawn from the national registry-based GEOCAP study. National annual maps of agricultural land use were developed to assess proximity to 13 crop types. Multivariate logistic regression models adjusted for age were used to evaluate the association with the densities of crops within 1000 m of children's addresses. A hierarchical classification was also used to categorize children according to their agricultural neighborhood profiles.

Results

The majority of children (69 %) lived less than 1000 m from crops at time of diagnosis/inclusion. Barley and viticulture densities were positively associated with ALL: Odds ratio (OR) = 1.05 (1.00–1.10) and 1.06 (0.99–1.13) for a density increase of 3 % and 10 %, respectively. Two agricultural neighborhood profiles were also associated with an increased risk of ALL: ‘Vines (large areas)’, OR = 1.35 (1.03–1.78) and ‘Wheat with diverse crops’, OR = 1.28 (1.10–1.49). The results remained stable across sensitivity analyses.

Conclusion

Our results support the hypothesis of a role of agricultural pesticide exposures in childhood ALL risk. Future research should focus on the chemical substances applied to crops.

背景：农药暴露被怀疑是几种儿童癌症的危险因素，特别是急性白血病（AL）和最常见的急性淋巴细胞白血病（ALL）。由于农业使用农药而造成的环境暴露的作用仍然存在争议。目的：该研究旨在调查法国不同作物的住宅邻近程度（作为农药暴露的代表）是否与AL风险增加有关。方法：我们纳入了2008-2013年诊断的2731例AL病例和28,303例对照，这些病例代表了当代法国儿科人群（1-14岁），来自全国基于登记的GEOCAP研究。制定了全国农业土地利用年度地图，以评估与13种作物类型的接近程度。使用调整年龄的多变量logistic回归模型来评估与儿童地址1000米内作物密度的关系。分层分类也被用于根据他们的农业社区概况对儿童进行分类。结果：大多数儿童（69%）在诊断/纳入时生活在距离作物不到1000米的地方。大麦和葡萄密度与ALL呈显著正相关：当密度增加3%和10%时，优势比分别为1.05（1.00-1.10）和1.06（0.99-1.13）。两种农业社区情况也与ALL风险增加有关：“葡萄（大面积）”，OR = 1.35（1.03-1.78）和“小麦与多种作物”，OR = 1.28（1.10-1.49）。结果在敏感性分析中保持稳定。结论：我们的研究结果支持农药暴露与儿童ALL风险有关的假设。今后的研究应集中在应用于作物的化学物质上。

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引用次数: 0

Paternal preconception urinary concentrations of bisphenol A and F in relation to in vitro fertilization outcomes: A prospective cohort study 父亲孕前尿双酚A和F浓度与体外受精结果的关系：一项前瞻性队列研究。

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2025-12-20 DOI: 10.1016/j.ijheh.2025.114739

Ningxin Zhang , Yue Zhao , Lingling Zhai , Yannan Zhao , Kuai Yu , Lihong Jia

Bisphenol F (BPF), a substitute for the widely recognized environmental endocrine-disrupting chemical bisphenol A (BPA), is increasingly utilized in consumer products. Despite the well-established association of BPA with adverse reproductive outcomes, the association with BPF exposure on in vitro fertilization (IVF) outcomes remains largely unknown, particularly regarding paternal exposure, given that male factors already account for approximately 40 % of global infertility. We aimed to evaluate the associations between exposure to BPA and BPF and IVF outcomes among men undergoing assisted reproductive technology (ART) treatment. The study enrolled 128 men undergoing ART treatment from a prospective cohort study in Shenyang, China, between September 2020 and February 2021. Urinary levels of bisphenols using mass spectrometry. Compared to the lowest quartile, men with urinary BPA concentrations in the highest quartile had 0.10 lower adjusted fertilization rate (95 % CI: 0.18, −0.02). Men with urinary BPA concentrations in the highest quartile had a lower probability of live birth compared to those with concentrations in the lowest quartile (adjusted RR = 0.27, 95 % CI: 0.09, −0.86). The quantile g-computation (QGC) model revealed that per quantile increase in the bisphenol mixture was inversely associated with fertilization rate (adjusted β = −0.04, 95 % CI: 0.07, −0.01) and probability of live birth (adjusted RR = 0.54, 95 % CI: 0.34, 0.85). Male co-exposure to BPA and BPF was inversely associated with IVF outcomes, including reduced fertilization rate and the probability of a live birth. Public health initiatives should prioritize reducing bisphenol exposure in men to mitigate infertility risks, not merely focusing on women.

双酚F （BPF）是公认的环境内分泌干扰化学物质双酚a （BPA）的替代品，在消费品中的应用越来越广泛。尽管双酚a与不良生殖结果的关系已得到证实，但BPA暴露与体外受精（IVF）结果的关系在很大程度上仍然未知，特别是关于父亲暴露，因为男性因素已经占全球不孕症的40%左右。我们的目的是评估在接受辅助生殖技术（ART）治疗的男性中BPA和BPF暴露与IVF结果之间的关系。该研究从2020年9月至2021年2月在中国沈阳进行的一项前瞻性队列研究中招募了128名接受ART治疗的男性。用质谱法测定尿液中双酚类物质的含量。与最低的四分位数相比，尿液中BPA浓度最高的四分位数的男性调整受精率降低了0.10 （95% CI: 0.18, -0.02）。尿中BPA浓度最高的男性与浓度最低的男性相比，活产的可能性更低（调整后RR = 0.27, 95% CI: 0.09, -0.86）。分位数g计算（QGC）模型显示，双酚混合物每增加分位数与受精率（调整后的β = -0.04, 95% CI: 0.07, -0.01）和活产概率（调整后的RR = 0.54, 95% CI: 0.34, 0.85）呈负相关。男性同时暴露于BPA和BPF与体外受精结果呈负相关，包括受精率降低和活产的可能性。公共卫生倡议应优先减少男性双酚暴露，以减轻不育风险，而不仅仅是关注女性。

{"title":"Paternal preconception urinary concentrations of bisphenol A and F in relation to in vitro fertilization outcomes: A prospective cohort study","authors":"Ningxin Zhang , Yue Zhao , Lingling Zhai , Yannan Zhao , Kuai Yu , Lihong Jia","doi":"10.1016/j.ijheh.2025.114739","DOIUrl":"10.1016/j.ijheh.2025.114739","url":null,"abstract":"<div><div>Bisphenol F (BPF), a substitute for the widely recognized environmental endocrine-disrupting chemical bisphenol A (BPA), is increasingly utilized in consumer products. Despite the well-established association of BPA with adverse reproductive outcomes, the association with BPF exposure on <em>in vitro</em> fertilization (IVF) outcomes remains largely unknown, particularly regarding paternal exposure, given that male factors already account for approximately 40 % of global infertility. We aimed to evaluate the associations between exposure to BPA and BPF and IVF outcomes among men undergoing assisted reproductive technology (ART) treatment. The study enrolled 128 men undergoing ART treatment from a prospective cohort study in Shenyang, China, between September 2020 and February 2021. Urinary levels of bisphenols using mass spectrometry. Compared to the lowest quartile, men with urinary BPA concentrations in the highest quartile had 0.10 lower adjusted fertilization rate (95 % CI: 0.18, −0.02). Men with urinary BPA concentrations in the highest quartile had a lower probability of live birth compared to those with concentrations in the lowest quartile (adjusted RR = 0.27, 95 % CI: 0.09, −0.86). The quantile g-computation (QGC) model revealed that per quantile increase in the bisphenol mixture was inversely associated with fertilization rate (adjusted β = −0.04, 95 % CI: 0.07, −0.01) and probability of live birth (adjusted RR = 0.54, 95 % CI: 0.34, 0.85). Male co-exposure to BPA and BPF was inversely associated with IVF outcomes, including reduced fertilization rate and the probability of a live birth. Public health initiatives should prioritize reducing bisphenol exposure in men to mitigate infertility risks, not merely focusing on women.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"272 ","pages":"Article 114739"},"PeriodicalIF":4.4,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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