{"title":"Laparoskopik Sleeve Gastrektomi Materyallerinde Rutin Histopatolojik İncelemenin Önemi ve Preoperatif Üst Gastrointestinal Endoskopik Biyopsinin Rolü","authors":"Döndü Nergi̇z","doi":"10.25048/tudod.1009269","DOIUrl":"https://doi.org/10.25048/tudod.1009269","url":null,"abstract":"","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127282938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: As diabetes mellitus and its complications become more prevalent in the world, it is becoming an important public health problem. Previous studies have investigated vitamin D in the context of diabetes mellitus and its complications.. Microalbuminuria is important as the initial level of diabetic nephropathy. In this context, we aimed to investigate the level and deficiency of vitamin D in diabetic patients with microalbuminuria. Material and Methods: 52 type 1 (20.1%) and 206 (79.9%) type 2 diabetes patients who applied to the outpatient Endocrinology and Metabolic Diseases clinic between April 2019 and December 2020 were included in the study. Patients were classified according to microalbuminuria. Fasting glucose, HbA1c, duration of diabetes, and 25 (OH) Vitamin D levels and mean waist circumference were compared between the groups. Finally, the groups were compared according to diabetes type and microalbuminuria. Results: Urinary albumin/creatinine rates (UAC) in 159 (42.7%) diabetic patients were in normal range, and 65 (17.5%) diabetics had UAC between 30-300 mcg. 12 (3.2%) had UAC >300 mcg. 22 (5.9%) had chronic renal failure. Vitamin D deficiency was 61.6% and vitamin D insufficiency was 28.6% in all study groups. Median GFR was 98 (38-136) ml/dk and median 25 (OH) D level was 17.1 (5.0-44.2)mg/dl. 25 (OH) Vitamin D levels and GFR were found to be significantly lower in the microalbuminuria group (p<0.01). 25 (OH) D levels were found to be low in both type 1 and type 2 diabetes patients with the complication of microalbuminuria, however only in type 1 diabetes patients low vitamin D this was found significant (p=0.01) Conclusion: 25 (OH) vitamin D deficiency and insufficiency were found to be more common in patients with diabetes. with microalbuminuria, which was more significant in type 1 diabetes patients The underlying mechanisms and potential therapeutic effect of vitamin D should be further investigated.
{"title":"Vitamin D Deficiency and Microalbuminuria in Patients with Diabetes Mellitus","authors":"Savaş Karataş, Ş. Köse, Y. Hacıoğlu","doi":"10.25048/tudod.942751","DOIUrl":"https://doi.org/10.25048/tudod.942751","url":null,"abstract":"Aim: As diabetes mellitus and its complications become more prevalent in the world, it is becoming an important public health problem. Previous studies have investigated vitamin D in the context of diabetes mellitus and its complications.. Microalbuminuria is important as the initial level of diabetic nephropathy. In this context, we aimed to investigate the level and deficiency of vitamin D in diabetic patients with microalbuminuria. Material and Methods: 52 type 1 (20.1%) and 206 (79.9%) type 2 diabetes patients who applied to the outpatient Endocrinology and Metabolic Diseases clinic between April 2019 and December 2020 were included in the study. Patients were classified according to microalbuminuria. Fasting glucose, HbA1c, duration of diabetes, and 25 (OH) Vitamin D levels and mean waist circumference were compared between the groups. Finally, the groups were compared according to diabetes type and microalbuminuria. Results: Urinary albumin/creatinine rates (UAC) in 159 (42.7%) diabetic patients were in normal range, and 65 (17.5%) diabetics had UAC between 30-300 mcg. 12 (3.2%) had UAC >300 mcg. 22 (5.9%) had chronic renal failure. Vitamin D deficiency was 61.6% and vitamin D insufficiency was 28.6% in all study groups. Median GFR was 98 (38-136) ml/dk and median 25 (OH) D level was 17.1 (5.0-44.2)mg/dl. 25 (OH) Vitamin D levels and GFR were found to be significantly lower in the microalbuminuria group (p<0.01). 25 (OH) D levels were found to be low in both type 1 and type 2 diabetes patients with the complication of microalbuminuria, however only in type 1 diabetes patients low vitamin D this was found significant (p=0.01) Conclusion: 25 (OH) vitamin D deficiency and insufficiency were found to be more common in patients with diabetes. with microalbuminuria, which was more significant in type 1 diabetes patients The underlying mechanisms and potential therapeutic effect of vitamin D should be further investigated.","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122402266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Birgül Altuğ, İnci Turan, Hale SAYAN ÖZAÇMAK, V. H. Özaçmak
{"title":"Deneysel Diyabetin Serebellar CREB / BDNF Yolağı, Oksidatif Stres ve Motor Fonksiyona Etkisi","authors":"Birgül Altuğ, İnci Turan, Hale SAYAN ÖZAÇMAK, V. H. Özaçmak","doi":"10.25048/tudod.976507","DOIUrl":"https://doi.org/10.25048/tudod.976507","url":null,"abstract":"","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126115778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The sense of coherence is a concept that reflects people’s coping with stress in a way that contributes positively to their health. The relationship of this concept with chronic diseases has attracted attention. Based on this, our study aims to investigate the relationship between the sense of coherence and glycemic control in patients with diabetes who applied to our Obesity outpatient clinic. Material and Methods: In this cross-sectional study, 319 Type 2 Diabetes patients who had diabetes for less than 10 years and who did not receive treatment changes between two HbA1c values measured at three months intervals were included in this cross-sectional study. The patients were divided into two groups according to the HbA1c level. Those with a HbA1c level of 7 and above were included in the group with poor glycemic control, those with a HbA1c level below 7, and those with optimal glycemic control. Depression, anxiety, and sense of coherence were compared between the group with good and poor glycemic control. In order to test the differences between the two measurements; independent samples t test for parametric tests, Mann-Whitney-U test for non-parametric tests and Pearson chi-square analysis for testing the differences between categoric measurements was performed. Results: No difference was found between the groups with poor and glycemic control in terms of depression, anxiety and sense of coherence (p = 0.441; p = 0.688; p = 0.761). Conclusion: In our study, no relationship was found between glycemic control and sense of coherence.
{"title":"Diyabetik Hastalarda Bütünlük Duygusu ile Glisemik Kontrol İlişkisi","authors":"Levent Çoban, Ceren Beyca, H. Mutlu","doi":"10.25048/tudod.835154","DOIUrl":"https://doi.org/10.25048/tudod.835154","url":null,"abstract":"Aim: The sense of coherence is a concept that reflects people’s coping with stress in a way that contributes positively to their health. The relationship of this concept with chronic diseases has attracted attention. Based on this, our study aims to investigate the relationship between the sense of coherence and glycemic control in patients with diabetes who applied to our Obesity outpatient clinic. Material and Methods: In this cross-sectional study, 319 Type 2 Diabetes patients who had diabetes for less than 10 years and who did not receive treatment changes between two HbA1c values measured at three months intervals were included in this cross-sectional study. The patients were divided into two groups according to the HbA1c level. Those with a HbA1c level of 7 and above were included in the group with poor glycemic control, those with a HbA1c level below 7, and those with optimal glycemic control. Depression, anxiety, and sense of coherence were compared between the group with good and poor glycemic control. In order to test the differences between the two measurements; independent samples t test for parametric tests, Mann-Whitney-U test for non-parametric tests and Pearson chi-square analysis for testing the differences between categoric measurements was performed. Results: No difference was found between the groups with poor and glycemic control in terms of depression, anxiety and sense of coherence (p = 0.441; p = 0.688; p = 0.761). Conclusion: In our study, no relationship was found between glycemic control and sense of coherence.","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127125063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Merkezi Yolla Enjekte Edilen Histamin ve Reseptör Antagonistlerinin, Sıçanların Yem, Su Alımı ve Vücut Ağırlıkları Üzerine Etkileri","authors":"Burcin Altinbas, G. Bayram, Murat Yalçın","doi":"10.25048/tudod.968923","DOIUrl":"https://doi.org/10.25048/tudod.968923","url":null,"abstract":"","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125309297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Relationship Between Eating Behaviors and Learned Helplessness among the People with Overweight and Affected by Obesity: A Cross-Sectional Study","authors":"A. Ozdemir, E. Serin, T. Şahin","doi":"10.25048/tudod.970776","DOIUrl":"https://doi.org/10.25048/tudod.970776","url":null,"abstract":"","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116459184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of Relationship Between Body Mass Index and Neck Biomechanics in Healty Young Adults: A Cross-Sectional Study in a Single Center","authors":"H. Kılınç, A. Karaduman","doi":"10.25048/tudod.852027","DOIUrl":"https://doi.org/10.25048/tudod.852027","url":null,"abstract":"","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130081059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of the Relationship between Healthy Lifestyle Behaviors and the Risk of Type 2 Diabetes in Healthcare Professionals","authors":"E. Serin, Kevser Işık, Ahmet Ozdemir","doi":"10.25048/tudod.872780","DOIUrl":"https://doi.org/10.25048/tudod.872780","url":null,"abstract":"","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116361157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Prediabetes is a condition with hyperglycemia and risk of development type 2 diabetes mellitus (T2DM). The aim of this study is to determine the concentrations of blood pressure, serum lipoproteins, glucose and insulin levels as well as the concentrations of α-klotho and FGF-23 parameters. We also aim at the correlation between all these parameters in obese prediabetics and obese normoglycemics. Material and Methods: A total of 26 obese normoglycemic (control group) and 25 obese prediabetic individuals were included in this study. Glucose, haemoglobin A1c (HbA1c) and cholesterols levels were analyzed as part of a routine procedure in the biochemistry laboratories of our hospital using an autoanalyzer. In order to determine α-klotho and fibroblast growth factor-23 (FGF-23) levels, ELISA method was used. Student-t Test and Mann-Whitney U Test were used for evaluation of parameters’ statistical analyzes. Spearman correlation test was used for correlation analysis. Results: According to the findings, a significant increase was detected in serum LDL-C, TC, HbA1c, glucose, insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) levels in the obese prediabetic group compared to the control group (p <0.05). However, serum α-klotho and FGF-23 levels were found to be significantly lower in the obese prediabetic group compared to the control group (p <0.05). α-klotho and FGF-23 values showed strong negative correlation when compared with HOMA-IR values separately (p <0.01). Conclusion: These findings indicate that α-klotho and FGF-23 levels decrease in prediabetic patients and are associated with insulin resistance. The results of our study will make a significant contribution to the literature.
{"title":"Evaluation of α-klotho, FGF-23 and Insulin Resistance in Obese Prediabetics","authors":"C. Severcan, A. Hamamcioglu, T. Bayraktaroğlu","doi":"10.25048/tudod.926907","DOIUrl":"https://doi.org/10.25048/tudod.926907","url":null,"abstract":"Aim: Prediabetes is a condition with hyperglycemia and risk of development type 2 diabetes mellitus (T2DM). The aim of this study is to determine the concentrations of blood pressure, serum lipoproteins, glucose and insulin levels as well as the concentrations of α-klotho and FGF-23 parameters. We also aim at the correlation between all these parameters in obese prediabetics and obese normoglycemics. Material and Methods: A total of 26 obese normoglycemic (control group) and 25 obese prediabetic individuals were included in this study. Glucose, haemoglobin A1c (HbA1c) and cholesterols levels were analyzed as part of a routine procedure in the biochemistry laboratories of our hospital using an autoanalyzer. In order to determine α-klotho and fibroblast growth factor-23 (FGF-23) levels, ELISA method was used. Student-t Test and Mann-Whitney U Test were used for evaluation of parameters’ statistical analyzes. Spearman correlation test was used for correlation analysis. Results: According to the findings, a significant increase was detected in serum LDL-C, TC, HbA1c, glucose, insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) levels in the obese prediabetic group compared to the control group (p <0.05). However, serum α-klotho and FGF-23 levels were found to be significantly lower in the obese prediabetic group compared to the control group (p <0.05). α-klotho and FGF-23 values showed strong negative correlation when compared with HOMA-IR values separately (p <0.01). Conclusion: These findings indicate that α-klotho and FGF-23 levels decrease in prediabetic patients and are associated with insulin resistance. The results of our study will make a significant contribution to the literature.","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133771695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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