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Advancements in the Treatment of Diabetic Macular Edema: Current Strategies and Future Directions 糖尿病黄斑水肿的治疗进展:当前策略与未来方向
Pub Date : 2024-06-03 DOI: 10.12775/jehs.2024.73.51687
Zuzanna Czach, Magdalena Czach, Dominika Bachurska, Wojciech Kopacz, Łukasz Mazurek, Monika Stradczuk, Wojciech Mazurek, Barbara Rękas, Barbara Kruczyk, Mateusz Piętak, Joanna Olędzka
This narrative review examines current and emerging treatment strategies for diabetic macular edema (DME), a complication of diabetic retinopathy characterised by fluid accumulation in the macula, which can lead to vision impairment. The incidence of DME is particularly high in patients with long-standing diabetes and advanced retinopathy. The current treatment options for DME include anti-vascular endothelial growth factor (anti-VEGF) agents, corticosteroids, and laser therapies. Anti-VEGF agents, including bevacizumab, ranibizumab, aflibercept, and the more recently developed brolucizumab and faricimab, have been demonstrated to reduce macular thickness and improve visual acuity. Brolucizumab offers the advantage of fewer injections due to its longer duration of action, although it carries a higher risk of ocular inflammation compared to other anti-VEGF agents. The dual inhibition of the VEGF and angiopoietin-2 (Ang-2) pathways by faricimab may enhance vascular stability and reduce inflammation, potentially improving patient outcomes. Steroid therapies, including dexamethasone, fluocinolone acetonide, and triamcinolone acetonide, represent an alternative for patients who do not respond adequately to anti-VEGF treatment. Laser therapies, including focal, navigated, and subthreshold laser treatments, remain a crucial component in the management of DME, with the ability to seal leaking vessels and reduce fluid accumulation. In order to achieve the best outcomes for patients, it is essential to continue to advance these treatment modalities and adopt a personalised, multifaceted approach.
糖尿病黄斑水肿(DME)是糖尿病视网膜病变的一种并发症,主要表现为黄斑部液体积聚,可导致视力受损。在长期糖尿病和晚期视网膜病变患者中,DME的发病率尤其高。目前治疗 DME 的方法包括抗血管内皮生长因子(anti-VEGF)药物、皮质类固醇和激光疗法。抗血管内皮生长因子药物,包括贝伐珠单抗、雷尼珠单抗、阿弗利百普,以及最近开发的布卢单抗和法立替单抗,已被证实可以减少黄斑厚度,提高视力。虽然与其他抗血管内皮生长因子药物相比,布卢单抗有眼部炎症风险较高的风险,但由于其作用时间较长,因此注射次数较少。法替单抗对血管内皮生长因子(VEGF)和血管生成素-2(Ang-2)通路的双重抑制可能会增强血管稳定性并减少炎症,从而改善患者的预后。类固醇疗法,包括地塞米松、醋酸氟西诺龙和醋酸曲安奈德,是抗血管内皮生长因子治疗无效患者的另一种选择。激光疗法,包括病灶激光、导航激光和阈下激光治疗,仍然是治疗 DME 的重要组成部分,能够封闭渗漏血管并减少液体积聚。为了使患者获得最佳疗效,必须继续推进这些治疗模式,并采用个性化、多方面的方法。
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引用次数: 0
What do we know about body dysmorphic disorder - Review of current knowledge 我们对身体畸形障碍了解多少--现有知识回顾
Pub Date : 2024-05-23 DOI: 10.12775/jehs.2024.71.51251
Aleksandra Brożyna, Arkadiusz Bydliński, Anita Kwiatkowska, Sara Emerla, Natalia Małek, Konrad Karłowicz, Łukasz Ciulkiewicz, Patryk Pluta, Julia Lubomirska, Patrycja Figurowska, Maria Hermanowska
Introduction Body dysmorphic disorder, also known as dysmorphophobia, is a severe psychiatric disorder characterized by DSM-V as preoccupation with one or more perceived defects or flaws in physical appearance, that are not observable or appear slight to others. BDD can cause significant distress or impairment in social and occupational areas of life. It is often comorbid with other psychiatric conditions like major depressive disorder. Current ways of treatment include a combination of pharmacotherapy and cognitive-behavioral therapy.  Aim of the study To summarize current knowledge of body dysmorphic disorder, its pharmacological and non-pharmacological treatment, outline possible areas for further research, and raise the awareness of the disorder.  Material and methods  The review was based on the PubMed database and was carried out using keywords to determine the latest publications. Summary Body dysmorphic disorder is a relatively common and severe condition that greatly diminishes patients' quality of life. While helpful diagnostic tools exist, BDD diagnosis remains relatively uncommon, posing challenges for patients to receive adequate treatment and continuing their suffering. Despite identifying several factors contributing to the disorder, much remains unknown. Many patients do not respond to standard treatment options, highlighting the need for further studies into the disorder's neurobiology, causes, and alternate treatment approaches to achieve a deeper comprehension of BDD as the number of new cases increases every year.
简介:身体畸形障碍(Body dysmorphic disorder)又称畸形恐惧症,是一种严重的精神障碍,DSM-V 将其描述为对身体外观上的一种或多种缺陷或瑕疵的偏执,而这些缺陷或瑕疵在他人看来是无法观察到的或轻微的。BDD 可对生活中的社交和职业领域造成严重困扰或损害。它通常与重度抑郁障碍等其他精神疾病合并存在。目前的治疗方法包括药物疗法和认知行为疗法。 研究目的 总结目前对身体畸形障碍、其药物和非药物治疗的认识,概述可能的进一步研究领域,并提高人们对该障碍的认识。 材料和方法 该综述基于 PubMed 数据库,使用关键词确定最新发表的文章。摘要 躯体畸形障碍是一种相对常见的严重疾病,会大大降低患者的生活质量。虽然存在有用的诊断工具,但 BDD 诊断仍相对少见,这给患者接受适当治疗和继续忍受痛苦带来了挑战。尽管确定了导致该障碍的几个因素,但仍有许多未知因素。许多患者对标准治疗方案没有反应,随着每年新增病例数量的增加,我们需要进一步研究该疾病的神经生物学、病因和替代治疗方法,以便更深入地了解 BDD。
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引用次数: 0
A review of treatment of relapsing-remitting type of multiple sclerosis (RRMS) 复发缓解型多发性硬化症(RRMS)治疗综述
Pub Date : 2024-05-23 DOI: 10.12775/jehs.2024.71.51250
Arkadiusz Bydliński, Aleksandra Brożyna, Natalia Małek, Sara Emerla, Anita Kwiatkowska, Konrad Karłowicz, Maria Hermanowska, Julia Lubomirska, Patrycja Figurowska, Łukasz Ciulkiewicz, Patryk Pluta
Introduction Multiple sclerosis (SM) is the most common chronic inflammatory-demyelinating disease of the Central Nervous System. In its course, a multifocal damage is done to a nervous tissue - myelin sheaths surrounding axons become disintegrated. This process leads to a dysfunction of the electrical impulses passage along nerve fibers which occurs as various symptoms that hinder the functioning of the patients.  Aim of the study This review aims to summarize treatment methods of relapsing-remitting type of multiple sclerosis (RRMS). Following information will be presented: groups of medications, mechanism of its action, its most important side effects and its effectiveness. Material and method This review presents the current state of knowledge about relapsing-remitting type of multiple sclerosis (RRMS) treatment - it is based on Pubmed database and was carried out using keywords concerning the issues of multiple sclerosis. Cited articles were selected in order to base on up-to-date investigation results. Summary A wide range of therapeutic options let neurologists treat their patients accurately, but the basic knowledge about each substance should be assimilated to choose the best individual therapy. Patients suffering from multiple sclerosis differ from each other and a personal approach is needed to implement appropriate treatment as soon as possible. Early start allows patients to not to lose their everyday functioning areas, as the neurodegenerative process is stopped at the initial stage. If some changes in brain tissue structure are permanently done, neurologists should know the options of symptomatic treatment to alleviate a patient's suffering. 
导言 多发性硬化症(SM)是中枢神经系统最常见的慢性炎症性脱髓鞘疾病。在发病过程中,神经组织受到多处损伤--轴突周围的髓鞘解体。这一过程导致神经纤维的电脉冲传导功能障碍,从而出现各种症状,阻碍患者的功能。 研究目的 本综述旨在总结复发缓解型多发性硬化症(RRMS)的治疗方法。将介绍以下信息:药物类别、作用机制、最重要的副作用及其有效性。材料与方法 本综述介绍了有关复发性-缓解型多发性硬化症(RRMS)治疗的知识现状--它基于 Pubmed 数据库,并使用了有关多发性硬化症问题的关键词。引用文章的选择以最新调查结果为基础。摘要 广泛的治疗方案可让神经科医生准确地治疗患者,但应吸收有关每种物质的基本知识,以选择最佳的个体疗法。多发性硬化症患者的病情各不相同,因此需要因人而异,尽快实施适当的治疗。及早开始治疗可以使患者不丧失日常功能,因为神经退行性病变过程在最初阶段就被阻止了。如果脑组织结构永久性地发生了某些变化,神经科医生应了解对症治疗的方案,以减轻患者的痛苦。
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引用次数: 0
SGLT2-Inhibitors - significant role in Heart Failure treatment SGLT2 抑制剂--在心力衰竭治疗中发挥重要作用
Pub Date : 2024-05-22 DOI: 10.12775/jehs.2024.71.49418
Karol Wielgus, Piotr Bator, Maria Pawłowska, Karol Magiera, K. Rachwał, Maria Antos, Jan Ramian, Grzegorz Łyko
Heart failure (HF), which has a high morbidity and mortality rate, is nevertheless a common and crippling ailment, especially in older populations. The complicated pathophysiology of heart failure (HF), which includes oxidative stress, endothelial dysfunction, fibrosis, and inflammation, is frequently not sufficiently treated despite advances in medication. Inhibitors of the sodium-glucose co-transporter 2 (SGLT2) have become a key treatment for HF in patients with varying left ventricular ejection fractions (LVEF). SGLT2 inhibitors have been shown in recent clinical trials to considerably lower hospitalization rates for heart failure, cardiovascular mortality, and all-cause mortality. The mechanisms of SGLT2 inhibitors, such as better ventricular loading, increased heart metabolic efficiency, and decreased inflammation and necrosis, are covered in this review. Additionally, we provide an overview of four important clinical trials—DAPA-HF, EMPEROR-Reduced, EMPEROR-Preserved, and DELIVER—highlighting their effectiveness in lowering unfavourable cardiovascular outcomes for patients with heart failure who have preserved (HFpEF), slightly reduced (HFmrEF), or reduced (HFrEF). The results validate the need for SGLT2 inhibitors in all-inclusive HF treatment plans by highlighting their adaptability and safety in a range of clinical contexts.
心力衰竭(HF)的发病率和死亡率都很高,是一种常见的致残性疾病,尤其是在老年人群中。心力衰竭(HF)的病理生理学非常复杂,包括氧化应激、内皮功能障碍、纤维化和炎症,尽管药物治疗取得了进展,但治疗效果往往不够理想。钠-葡萄糖共转运体 2(SGLT2)抑制剂已成为治疗不同左心室射血分数(LVEF)患者心力衰竭的关键药物。最近的临床试验表明,SGLT2 抑制剂可大大降低心衰住院率、心血管死亡率和全因死亡率。本综述将介绍 SGLT2 抑制剂的作用机制,如改善心室负荷、提高心脏代谢效率、减少炎症和坏死。此外,我们还概述了四项重要的临床试验--DAPA-HF、EMPEROR-Reduced、EMPEROR-Preserved 和 DELIVER--它们在降低保留型(HFpEF)、轻微降低型(HFmrEF)或降低型(HFrEF)心衰患者的不利心血管后果方面的有效性。这些结果证明了在全套心力衰竭治疗方案中使用 SGLT2 抑制剂的必要性,突出了它们在各种临床情况下的适应性和安全性。
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引用次数: 0
Breast milk – a living superfood. Review of current knowledge 母乳--有生命的超级食品现有知识回顾
Pub Date : 2024-05-22 DOI: 10.12775/jehs.2024.71.51247
Patrycja Figurowska, Natalia Małek, Sara Emerla, Aleksandra Brożyna, Anita Kwiatkowska, Arkadiusz Bydliński, Konrad Karłowicz, Maria Hermanowska, Julia Lubomirska, Łukasz Ciulkiewicz, Patryk Pluta
Introduction: Breastfeeding is considered the best nutrition for infants, including born preterm due to containing optimal ingredients for development and growth. Breast milk is a rich source of nutrients, it also contains diverse types of bacteria, which play a role in infant’s gastrointestinal tract colonization and preserving mammary health. Composition of human milk varies depending on numerous maternal and infant factors. Aim of the study: The aim of the study was to summarize the current knowledge about the content of nutrients, bioactive factors and microbiota diversity in human milk depending on various factors. Materials and methods: The work is a review of 26 mainly English-language scientific publications from 1989-2024 posted on the PubMed platform. Results: Milk composition changes in addition to several factors. Depending on postnatal age: preterm milk has higher content of protein, fat and immunological factors and lower concentration of lactose than term milk. Depending on milk maturity: Colostrum is higher in protein but lower in lactose, fat and energy than mature milk. Human milk is also a source of viable bacteria important for developing infant’s gut microbiota, but the diversity of bacterial strains in milk may vary. Depending on mode of delivery: milk of mothers after spontaneous labour contents more probiotic vaginal- and enteric-associated bacteria, while milk of mothers after C-section has more skin-associated microbiota. Depending on mother’s weight: milk of overweight mothers is lower in probiotic- and higher in pathogenic bacteria. Alcohol, nicotine, and some medications also have negative impact on produced milk. Conclusions: Human milk varies from woman to woman and its composition depends on several factors. Postnatal and gestational stage, delivery mode, mother's weight and certain substances have been found to be important factors influencing the constitution of breast milk, including nutrients, microbiota and volume of milk.
引言母乳被认为是婴儿(包括早产儿)的最佳营养品,因为它含有促进发育和成长的最佳成分。母乳营养丰富,还含有多种细菌,在婴儿胃肠道定植和保护乳腺健康方面发挥作用。母乳的成分因母体和婴儿的多种因素而异。研究目的本研究旨在总结目前有关母乳中营养成分、生物活性因子含量和微生物群多样性的知识,这些知识取决于各种因素。材料和方法:本研究综述了 PubMed 平台上发布的 1989-2024 年间 26 篇主要为英文的科学出版物。结果牛奶成分的变化与多种因素有关。取决于产后年龄:与足月牛奶相比,早产牛奶的蛋白质、脂肪和免疫因子含量较高,乳糖浓度较低。取决于乳汁的成熟度:初乳的蛋白质含量比成熟乳高,但乳糖、脂肪和能量含量比成熟乳低。人奶也是对婴儿肠道微生物群发育很重要的可存活细菌的来源,但牛奶中细菌菌株的多样性可能有所不同。取决于分娩方式:自然分娩后母亲的乳汁中含有更多益生菌阴道和肠道相关细菌,而剖腹产后母亲的乳汁中含有更多皮肤相关微生物群。取决于母亲的体重:超重母亲的乳汁中益生菌含量较低,而致病菌含量较高。酒精、尼古丁和一些药物也会对母乳产生负面影响。结论母乳因人而异,其成分取决于多种因素。研究发现,产后和妊娠阶段、分娩方式、母亲体重和某些物质是影响母乳成分(包括营养成分、微生物群和乳汁量)的重要因素。
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引用次数: 0
Ultraviolet-Protective Clothing and Sunscreen: Sun-Protection for Healthy Skin 紫外线防护服和防晒霜:为健康皮肤提供防晒保护
Pub Date : 2024-05-22 DOI: 10.12775/jehs.2024.71.51237
Daria Sieniawska, Patrycja Proszowska, Magda Madoń, Zuzanna Kotowicz, Adrianna Orzeł, Aleksandra Pich-Czekierda, Julia Sieniawska
Introduction Prolonged exposure to ultraviolet (UV) radiation from the sun poses numerous risks to the skin, ranging from premature aging to serious health conditions such as skin cancer. UV radiation can penetrate the skin's surface, causing damage to its cells and DNA, which can lead to the formation of wrinkles, sunspots, and other signs of aging. Therefore, consistent and effective sun protection is essential for maintaining the health and vitality of the skin, as well as reducing the risk of sun-related skin damage and diseases. Aim of the study The objective of the study is to conduct a thorough investigation into different aspects of photoprotection and its effects on the skin. This entails assessing the effectiveness and safety of sunscreens, as well as evaluating the impact of sun-protection clothing on skin health. Materials and methods The purpose of this review is to assess the current literature of the effectiveness of the various sun protection measures. The literature was reviewed in the Pubmed, Google Scholar data base. Results Prolonged UV exposure incites photoaging, carcinogenesis, and immunosuppression, amplifying the risk of skin malignancies. Sun-protective clothing, with adequate UPF ratings, emerges as a pivotal element in mitigating UV-induced skin damage, notably reducing the development of pigmented moles and melanoma. Furthermore, effective sunscreen usage, coupled with broad-spectrum protection, is essential in averting UV-induced skin damage and curbing the incidence of skin cancer. These findings emphasize the imperative of comprehensive photoprotection strategies, integrating sunscreen application, sun-protective clothing, and individual risk assessment, to safeguard against solar-induced skin damage and mitigate the prevalence of skin cancer.
导语:长期暴露于阳光中的紫外线(UV)辐射会给皮肤带来许多风险,从过早衰老到严重的健康问题,如皮肤癌。紫外线辐射可穿透皮肤表面,对细胞和 DNA 造成损害,从而导致皱纹、晒斑和其他衰老迹象的形成。因此,持续有效的防晒对于保持皮肤的健康和活力以及降低与阳光相关的皮肤损伤和疾病风险至关重要。研究目的 这项研究的目的是彻底调查光防护的各个方面及其对皮肤的影响。这需要评估防晒霜的有效性和安全性,以及防晒服对皮肤健康的影响。材料和方法 本综述的目的是评估各种防晒措施有效性的现有文献。相关文献在 Pubmed 和 Google Scholar 数据库中进行了查阅。结果 长期暴露在紫外线下会引起光老化、致癌和免疫抑制,从而增加患皮肤恶性肿瘤的风险。防晒服具有足够的 UPF 值,是减轻紫外线引起的皮肤损伤的关键因素,尤其能减少色素痣和黑色素瘤的发生。此外,有效使用防晒霜,加上广谱防护,对于避免紫外线引起的皮肤损伤和遏制皮肤癌的发病率至关重要。这些发现强调,必须采取综合的光防护策略,将涂抹防晒霜、穿防晒服和个人风险评估结合起来,以防止太阳诱发的皮肤损伤,降低皮肤癌的发病率。
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引用次数: 0
Clinical Frailty Scale - frailty assessment and rehabilitation potential 临床虚弱量表--虚弱评估和康复潜力
Pub Date : 2024-05-22 DOI: 10.12775/jehs.2024.71.51507
Szymon Wiśniewski, Weronika Hołownia, Wiktoria Julia Krzesłowska, Paulina Pytel, Kamila Szewczyk, Bartłomiej Szewczyk
Background: Studies show a significant increase in frailty prevalence among older adults worldwide. Fortunately, several well-established and user-friendly screening tools can effectively identify frailty in older adults. Objectives: This article examines the Clinical Frailty Scale's effectiveness in informing treatment decisions for older adults in ambulatory care settings, analyzing its potential to improve patient care. Methods: On April 1, 2024, the PubMed database was searched for articles on the Clinical Frailty Scale in elderly patients. The 116 most pertinent and current articles, written in English and published within the past few years, were analyzed, and 38 were selected and categorized by content and topic.   Limitations: This study is limited because it is not a meta-analysis and thus does not examine the quality of the evidence presented in each article. Conclusions: Frailty research has illuminated aging and its potential biological causes. The Clinical Frailty Scale effectively identifies vulnerable individuals. By using the CFS to assess frailty risk, healthcare providers can personalize treatment plans and improve overall care for older adults.
背景:研究表明,全球老年人体弱患病率大幅上升。幸运的是,有几种成熟且便于使用的筛查工具可以有效识别老年人的虚弱状况。目的:本文研究了临床虚弱量表:本文研究了临床虚弱量表在非住院治疗环境中为老年人的治疗决策提供信息的有效性,分析了其改善患者护理的潜力。方法:2024 年 4 月 1 日,我们在 PubMed 数据库中搜索了有关老年患者临床虚弱量表的文章。分析了过去几年内发表的 116 篇最相关的最新英文文章,选出 38 篇并按内容和主题进行了分类。 局限性:本研究具有局限性,因为它不是一项荟萃分析,因此没有对每篇文章中提供的证据的质量进行检查。结论:虚弱研究揭示了衰老及其潜在的生物学原因。临床虚弱量表可有效识别易受影响的个体。通过使用临床虚弱量表评估虚弱风险,医疗服务提供者可以为老年人制定个性化的治疗计划并改善整体护理。
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引用次数: 0
How can caffeine alleviate the motor symptoms of Parkinson’s disease? – the implications of adenosine 2A receptor antagonism 咖啡因如何缓解帕金森病的运动症状?- 腺苷 2A 受体拮抗剂的影响
Pub Date : 2024-05-22 DOI: 10.12775/jehs.2024.71.49808
Anna Wójcik, Aleksander Górny, Justyna Chwiejczak, Julita Młynarska, Jan Kościan, Karolina Szczerkowska, Anna Seroka, Maria Mitkowska, Maria Rybicka, Michał Obrębski
Introduction and purpose: Parkinson’s disease (PD) is the second most common neurodegenerative disease, mainly characterized by motor impairment with symptoms including rigidity, bradykinesia, rest tremor and imbalance. It develops upon degeneration of dopaminergic neurons in the substantia nigra associated with neuroinflammatory process initiated by alpha-synuclein deposits. Although, levodopa replacement therapy is the gold-standard treatment, majority of the treated patients develop dyskinesia as the side effect, resulting from altered function of dopamine receptors. It is thought that the abnormal pulsate release of dopamine can be prevented by antagonism of adenosine 2A receptors (A2ARs).Aim of the study: This review aims to outline the action mechanism of A2AR antagonism on motor performance, and thus evaluate the suggested implications of coffee consumption in PD. Material and method: The involvement of A2ARs in the pathology and treatment of PD has been analyzed based on the findings of many published studies examining the effects of A2AR modulation.Results: Blockage of A2ARs enhances the action of dopamine via D2 receptors on striatopallidal neurons, decreasing their hyperactivity, and exerts neuroprotective effect, suppressing the neuroinflammation.Conclusions: Istradefylline, being the only approved A2AR antagonist, was able to reduce total cumulative dose of levodopa, improve motor control, alleviate postural abnormalities, and provide a reduction in daily ‘off’ time experienced by patients. Recent findings suggest the effects of drinking one cup of coffee are comparable with ones obtained by the newly introduced medication, presumably via shared action mechanism by A2AR inhibition.
简介和目的:帕金森病(Parkinson's disease,PD)是第二大常见的神经退行性疾病,主要特征是运动障碍,症状包括僵直、运动迟缓、静止性震颤和失衡。这种疾病是由于黑质中的多巴胺能神经元发生变性,并伴有由α-突触核蛋白沉积引发的神经炎症过程。尽管左旋多巴替代疗法是黄金标准疗法,但大多数接受治疗的患者都会出现运动障碍这一副作用,这是多巴胺受体功能改变所致。据认为,通过拮抗腺苷 2A 受体(A2ARs),可以防止多巴胺的异常脉冲式释放:本综述旨在概述 A2AR 拮抗剂对运动表现的作用机制,从而评估饮用咖啡对帕金森病的影响。材料与方法根据许多已发表的关于A2AR调节作用的研究结果,对A2AR参与帕金森病的病理和治疗进行了分析:结果:阻断A2ARs可增强多巴胺通过D2受体对纹状体神经元的作用,降低其亢进性,并发挥神经保护作用,抑制神经炎症:伊斯替菲林是唯一获批的A2AR拮抗剂,能够减少左旋多巴的总累积剂量,改善运动控制,缓解姿势异常,并减少患者每天的 "休息 "时间。最近的研究结果表明,饮用一杯咖啡的效果与新引进药物的效果相当,这可能是通过抑制 A2AR 的共同作用机制实现的。
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引用次数: 0
Does sauna bathing prevent chronic obstructive pulmonary disease or Alzheimer's disease? May adults with cardiovascular disease use a sauna? A systematic review 桑拿浴能预防慢性阻塞性肺病或老年痴呆症吗?患有心血管疾病的成年人可以使用桑拿浴吗?系统回顾
Pub Date : 2024-05-22 DOI: 10.12775/jehs.2024.70.49802
Maciej Sobczyk, Małgorzata Słaboń, Małgorzata Pasztelan, Jarosław Pulikowski, Karolina Garbacz, Maria Maciąg, Julia Krawczuk vel Walczuk, Joanna Baran, Aleksandra Muca, Aleksandra Marczak
Recently, there has been a surge of interest in sauna bathing and its role in health aspects. However, there are few studies focusing on the association between regular sauntering and the risk of dementia and chronic obstructive pulmonary disease (COPD). Considerably better understood are the effects on the cardiovascular system. This study delves into contemporary scientific research on Finnish saunas, exploring their potential correlation with Alzheimer's disease prevention, their impact on vascular health in adults with cardiovascular disorders, and their association with reducing the risk of chronic obstructive pulmonary disease. Scientific studies published in PubMed, Scopus and Google Scholar databases were analyzed, including terms related to Finnish sauna, dementia, COPD and cardiovascular disease. The methodological quality and results of each study were evaluated. Sauna bathing in addition to being a relaxing lifestyle habit, remains a potential additional strategy which can be used in improving cardiovascular function in adults with well-controlled cardiovascular disorders. A limited amount of research has been identified on the correlation between sauna bathing and reduced risk of Alzheimer's disease and COPD. The accumulating evidence suggests that frequent sauna bathing may reduce the risk or severity of several vascular and nonvascular conditions including COPD and also moderate to high frequency of sauna bathing was associated with lowered risks of dementia and Alzheimer’s disease. Further research is required, especially large-scale cohort studies with repeated measurement on sauna to establish the potential mechanisms linking sauna bathing and either memory diseases or COPD and better understand the relationship between sauntering and cardiovascular health. Upcoming studies may become very promising for the development of sauna bathing as a new non-pharmacological treatment or prevention of various diseases and improvement in the quality of life.
最近,人们对桑拿浴及其在健康方面的作用产生了浓厚的兴趣。然而,很少有研究关注定期桑拿与痴呆症和慢性阻塞性肺病(COPD)风险之间的关系。人们对桑拿对心血管系统的影响了解得更多。本研究深入探讨了有关芬兰桑拿的当代科学研究,探讨了桑拿与阿尔茨海默氏症预防的潜在关联、桑拿对患有心血管疾病的成年人血管健康的影响,以及桑拿与降低慢性阻塞性肺病风险的关联。我们分析了发表在 PubMed、Scopus 和 Google Scholar 数据库中的科学研究,包括与芬兰桑拿、痴呆症、慢性阻塞性肺病和心血管疾病相关的术语。对每项研究的方法质量和结果进行了评估。桑拿浴不仅是一种放松身心的生活习惯,还是一种潜在的额外策略,可用于改善心血管疾病控制良好的成年人的心血管功能。关于桑拿浴与降低阿尔茨海默氏症和慢性阻塞性肺病风险之间的相关性,已发现的研究数量有限。不断积累的证据表明,经常洗桑拿浴可以降低包括慢性阻塞性肺病在内的几种血管性和非血管性疾病的风险或严重程度,而且中高频率的桑拿浴与降低痴呆症和阿尔茨海默氏症的风险有关。还需要进一步的研究,特别是对桑拿浴进行重复测量的大规模队列研究,以确定桑拿浴与记忆疾病或慢性阻塞性肺病之间的潜在联系机制,并更好地了解桑拿浴与心血管健康之间的关系。即将开展的研究可能会对桑拿浴作为一种新的非药物治疗或预防各种疾病和提高生活质量的方法的发展带来很大的希望。
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引用次数: 0
The promising form of supporting the treatment of depression 支持治疗抑郁症的有效形式
Pub Date : 2024-05-21 DOI: 10.12775/jehs.2024.71.49421
Izabela Halczuk, Bartłomiej Stachura, Justyna Górska, Samanta Gawryszczak, Anna Gliwa, Katarzyna Nowak
Introduction and purpose Recently, there has been a significant increase in interest in the dynamically developing field of science, nutripsychiatry, which has contributed to an increase in the number of studies conducted assessing the relationship between the use of a vegetarian nutritional model and its potential therapeutic impact on holistically understood mental health. Material and methods For the purposes of this work, a review of the literature available in the PubMed and Google Scholar search engines, was performed using the following keywords: vegetarian diet; depression; psychiatry. Works published before 2015 were excluded from the analysis. During the review of the literature of available scientific texts, attempts were made to comprehensively present the state of current knowledge. State of knowledge Numerous clinical studies support the beneficial effect of a vegetarian diet on mood by improving well-being and lower levels of anxiety and depression. However, there are also studies that did not show a relationship between the diet and the mood of the subjects, as well as studies indicating possible dangers associated with the use of this nutritional model. Conclusions The use of a vegetarian dietary pattern as a potential intervention is a promising method of non-pharmacological support. The amount of available scientific data confirming the beneficial effect of a vegetarian diet on mental health is insufficient to recommend it as a standard form of supporting the treatment of depression. Before implementing a vegetarian nutritional model, it is necessary to assess its safety in the patient and individualize dietary recommendations.
导言和目的 最近,人们对营养精神病学这一蓬勃发展的科学领域的兴趣显著增加,这也促使评估素食营养模式的使用与其对全面理解的心理健康的潜在治疗效果之间关系的研究数量增加。材料与方法 为了完成这项工作,我们使用以下关键词对 PubMed 和谷歌学术搜索引擎中的文献进行了综述:素食;抑郁症;精神病学。分析中不包括 2015 年之前发表的作品。在审查现有科学文献时,我们试图全面介绍当前的知识状况。知识现状 大量临床研究支持素食对情绪的有益影响,它能改善幸福感,降低焦虑和抑郁水平。然而,也有一些研究并未显示饮食与受试者的情绪之间存在关系,还有一些研究显示使用这种营养模式可能会带来危险。结论 将素食饮食模式作为一种潜在的干预措施,是一种很有前景的非药物支持方法。现有的科学数据证实了素食对心理健康的有益影响,但还不足以建议将其作为支持抑郁症治疗的标准形式。在实施素食营养模式之前,有必要评估其对患者的安全性,并提出个性化的饮食建议。
{"title":"The promising form of supporting the treatment of depression","authors":"Izabela Halczuk, Bartłomiej Stachura, Justyna Górska, Samanta Gawryszczak, Anna Gliwa, Katarzyna Nowak","doi":"10.12775/jehs.2024.71.49421","DOIUrl":"https://doi.org/10.12775/jehs.2024.71.49421","url":null,"abstract":"Introduction and purpose \u0000Recently, there has been a significant increase in interest in the dynamically developing field of science, nutripsychiatry, which has contributed to an increase in the number of studies conducted assessing the relationship between the use of a vegetarian nutritional model and its potential therapeutic impact on holistically understood mental health. \u0000Material and methods \u0000For the purposes of this work, a review of the literature available in the PubMed and Google Scholar search engines, was performed using the following keywords: vegetarian diet; depression; psychiatry. Works published before 2015 were excluded from the analysis. During the review of the literature of available scientific texts, attempts were made to comprehensively present the state of current knowledge. \u0000State of knowledge \u0000Numerous clinical studies support the beneficial effect of a vegetarian diet on mood by improving well-being and lower levels of anxiety and depression. However, there are also studies that did not show a relationship between the diet and the mood of the subjects, as well as studies indicating possible dangers associated with the use of this nutritional model. \u0000Conclusions \u0000The use of a vegetarian dietary pattern as a potential intervention is a promising method of non-pharmacological support. The amount of available scientific data confirming the beneficial effect of a vegetarian diet on mental health is insufficient to recommend it as a standard form of supporting the treatment of depression. Before implementing a vegetarian nutritional model, it is necessary to assess its safety in the patient and individualize dietary recommendations.","PeriodicalId":15567,"journal":{"name":"Journal of Education, Health and Sport","volume":"22 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141118194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Education, Health and Sport
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