Journal of Ginseng Research最新文献

{"title":"Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways","authors":"Honglin Xu ,&nbsp;Mingjie Pang ,&nbsp;Changlei Hu ,&nbsp;Tong Xu ,&nbsp;Guanghong Chen ,&nbsp;Guoyong Zhang ,&nbsp;Xin Han ,&nbsp;Yue Hua ,&nbsp;Yuting Wu ,&nbsp;Jiayi Zhang ,&nbsp;Yiming Bi ,&nbsp;Bin Liu ,&nbsp;Yingchun Zhou","doi":"10.1016/j.jgr.2025.01.001","DOIUrl":"10.1016/j.jgr.2025.01.001","url":null,"abstract":"<div><h3>Background</h3><div>Myocardial fibrosis and inflammation induce adverse cardiac remodeling post-myocardial infarction (MI). <em>Panax ginseng</em> (<em>P. ginseng</em>) is beneficial for diverse cardiovascular diseases. However, the therapeutic effect and molecular mechanism underlying cardiac remodeling are largely unclear.</div></div><div><h3>Methods</h3><div>A MI mouse model was constructed through permanent left anterior descending (LAD) coronary artery ligation. Transforming growth factor-β1 (TGF-β1) or lipopolysaccharide (LPS) was used for stimulating cardiac fibroblasts (CFs) or RAW264.7 macrophages to construct the collagen synthesis and inflammation model <em>in vitro</em>. The cardiac structure and function were detected through hematoxylin-eosin staining, Masson staining, and echocardiography, while myocardial fibrosis and inflammation markers were determined by Western-blot, immunohistochemistry, RT-PCR, and ELISA. Additionally, the Silent information regulator 1 (SIRT1)/nuclear factor-κB (NF-κB) mediated NOD like receptor 3 (NLRP3) inflammasome and TGF-β receptor I (TGFBR1) signaling pathways were also evaluated. A SIRT1 selective inhibitor (EX-527) was used for confirming the pharmacological mechanism of <em>P. ginseng</em>.</div></div><div><h3>Results</h3><div><em>In vivo</em>, <em>P. ginseng</em> alleviated ventricular remodeling, enhanced heart function, and ameliorated collagen I, collagen III, IL-1β, and IL-18 levels dose-dependently. Moreover, <em>P. ginseng</em> significantly suppressed NLRP3-caspase1 inflammasome and TGFBR1/Smads signaling in MI mice. <em>In vitro</em>, <em>P. ginseng</em> significantly suppressed collagen and inflammation markers, NLRP3 inflammasome and TGFBR1/Smads signaling in TGF-β1-induced CFs or LPS-stimulated RAW264.7 cells. Mechanistically, <em>P. ginseng</em> suppressed NF-κB activity while promoting SIRT1 expression. SIRT1 suppression by EX-527 partially abolished the protective effects of <em>P. ginseng</em> in TGF-β1-induced CFs.</div></div><div><h3>Conclusion</h3><div><em>P. ginseng</em> protects from adverse cardiac remodeling by attenuating myocardial fibrosis and inflammation post-MI through the regulation of SIRT1 and its downstream signaling pathways.</div></div>","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":"49 2","pages":"Pages 197-207"},"PeriodicalIF":6.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginseng as a therapeutic target to alleviate gut and brain diseases via microbiome regulation","authors":"Hamid Iqbal ,&nbsp;Yihyo Kim ,&nbsp;Mirim Jin ,&nbsp;Dong-kwon Rhee","doi":"10.1016/j.jgr.2024.04.005","DOIUrl":"10.1016/j.jgr.2024.04.005","url":null,"abstract":"<div><div>The human gut, which contains a diverse microbiome, plays an important role in maintaining physiological balance and preserving the immune system. The complex interplay between the central nervous system (CNS) and the gut microbiome has gained significant attention due to its profound implications for overall health, particularly for gut and brain disorders. There is emerging evidence that the gut-brain axis (GBA) represents a bidirectional communication system between the CNS and the gastrointestinal tract and plays a pivotal role in regulating many aspects of human health. Ginseng has shown potential to ameliorate conditions associated with dysbiosis, such as gut and CNS disorders by restoring microbial balance and enhancing gut barrier function. This comprehensive review provides valuable insights into the potential of ginseng as a herbal modulator of GBA as a therapeutic intervention for preventing and treating gut and neurological diseases via microbiota regulation to ultimately enhance overall health. Furthermore, we emphasize the therapeutic benefits of ginseng, its ability to enhance beneficial probiotics, such as Firmicutes, <em>Bacteroides</em>, <em>Lactobacillus, Bifidobacterium</em>, and <em>Akkermansia</em> while reducing pathogenic bacteria prevalence, such as <em>Helicobacter, Clostridium</em>, and Proteobacteria. Although the connection between ginseng regulation of microbial communities in response to the gut and neuropsychiatric disorders is lacking, additional investigations are warranted to elucidate the underlying mechanisms, optimize dosages, and explore the clinical relevance of ginseng in promoting GBA balance and ultimately overall health.</div></div>","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":"49 1","pages":"Pages 12-21"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140838453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Panax notoginseng saponins promotes angiogenesis after cerebral ischemia-reperfusion injury”[J Ginseng Res 48(6), November 2024, 592–602]","authors":"Haiyan Xiao ,&nbsp;Shusen Liu ,&nbsp;Binyu Fang ,&nbsp;Wenchao Zhang ,&nbsp;Min Wang ,&nbsp;Jingxue Ye ,&nbsp;Tianxiao Huang ,&nbsp;Li Cao ,&nbsp;Xiaojun Zhang ,&nbsp;Guibo Sun","doi":"10.1016/j.jgr.2024.12.001","DOIUrl":"10.1016/j.jgr.2024.12.001","url":null,"abstract":"","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":"49 1","pages":"Pages 103-104"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginsenoside-Re-rich ethanol extract of Panax ginseng berry enhances healthspan extension via mitostasis and NAD metabolism","authors":"Minjeong Kim ,&nbsp;Su Hwan Kim ,&nbsp;Juewon Kim ,&nbsp;Eun-Ju Jin ,&nbsp;Shibo Wei ,&nbsp;Yunju Jo ,&nbsp;Chang-Myung Oh ,&nbsp;Ki-Tae Ha ,&nbsp;Jong-Hwa Roh ,&nbsp;Wan-Gi Kim ,&nbsp;Donghyun Cho ,&nbsp;Young Jin Choi ,&nbsp;Su Myung Jung ,&nbsp;Dongryeol Ryu","doi":"10.1016/j.jgr.2024.11.002","DOIUrl":"10.1016/j.jgr.2024.11.002","url":null,"abstract":"<div><h3>Background</h3><div>Ginseng Berry Concentrate (GBC) enhances exercise capacity in mice, but the effects of its key component, ginsenoside Re (G-Re), on aging and mitochondrial function are not well understood. This study investigates the impact of G-Re on mitophagy and its potential to promote healthy aging.</div></div><div><h3>Methods</h3><div>Experiments in C2C12 myocytes and HeLa-mitoKeima-PARKIN cells assessed GBC and G-Re's effects on mitophagy, supported by Gene Set Enrichment Analysis. G-Re was identified as the primary component of GBC via high-performance liquid chromatography. The influence of G-Re on lifespan and healthspan was examined in <em>Caenorhabditis elegans</em>, with a focus on mitophagy pathways.</div></div><div><h3>Results</h3><div>GBC and G-Re significantly induced mitophagy and enhanced mitochondrial gene expression, improving mitochondrial function. G-Re extended lifespan and healthspan in <em>C. elegans</em>, effects absent in mitophagy-impaired mutants.</div></div><div><h3>Conclusion</h3><div>G-Re enhances mitochondrial function and promotes healthy aging through mitophagy, suggesting its potential for mitigating age-related functional declines.</div></div>","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":"49 1","pages":"Pages 92-102"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethanol extract of lymphanax with gypenoside 17 and ginsenoside Re exerts anti-inflammatory properties by targeting the AKT/NF-κB pathway","authors":"Wooram Choi ,&nbsp;Hyun Soo Kim ,&nbsp;Donghyun Kim ,&nbsp;Yong Deog Hong ,&nbsp;Hyoung-June Kim ,&nbsp;Ji Hye Kim ,&nbsp;Jong-Hoon Kim ,&nbsp;Jae Youl Cho","doi":"10.1016/j.jgr.2024.08.003","DOIUrl":"10.1016/j.jgr.2024.08.003","url":null,"abstract":"<div><h3>Background</h3><div>Ginseng is processed into several types such as white ginseng, red ginseng, and black ginseng, according to the processing methods such as drying, steaming, and heating. These processing conditions can change the portion of the useful ingredients. Recently, new processing method was established to develop ‘lymphanax’, an aged fresh white ginseng prepared under anaerobic condition. This aging process was revealed to increase the content of gypenoside 17 (Gyp17) as well as ginsenoside Re, known to have anti-inflammatory effects. As the next step, therefore, we aimed to investigate the anti-inflammatory activity of lymphanax using its ethanol extract of lymphanax (Lymphanax-EE).</div></div><div><h3>Methods</h3><div>LC-MS/MS identified the ginsenoside content of lymphanax-EE. A nitric oxide (NO) assay revealed the anti-inflammatory activity of lymphanax-EE. Pro-inflammatory gene expression was analyzed by quantitative PCR. Finally, we identified the underlying mechanism for the anti-inflammatory activity of lymphanax-EE through luciferase analysis, Western blotting, and CETSA.</div></div><div><h3>Results</h3><div>The LC-MS/MS analysis revealed lymphanax-EE to contain more protopanaxatriol-type ginsenosides, and Gyp17 than fresh ginseng. Lymphanax-EE (0–200 μg/ml) suppressed NO release and mRNA levels of pro-inflammatory cytokines such as iNOS and COX-2 in LPS-treated RAW264.7 cells. Moreover, lymphanax-EE (200 μg/ml) reduced the activity of NF-κB and phosphorylation of NF-κB signal proteins such as p65, p50, IκBα, and IKKα/β. Finally, lymphanax-EE (200 μg/ml) decreased the phosphorylation of IKKα/β induced by AKT overexpression. Among the components of lymphanax-EE, ginsenoside Re and Gyp17 were found to suppress AKT1 activity.</div></div><div><h3>Conclusions</h3><div>Lymphanax-EE-containing ginsenosides and Gyp17 with anti-inflammatory properties suppressed LPS-induced inflammation by reducing the NF-κB signal.</div></div>","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":"49 1","pages":"Pages 22-33"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex transcriptome network regulates the anthocyanin accumulation of four Panax ginseng cultivars in fruit","authors":"Jaewook Kim ,&nbsp;Bae Young Choi ,&nbsp;Donghwan Shim ,&nbsp;Ick-Hyun Jo","doi":"10.1016/j.jgr.2024.12.007","DOIUrl":"10.1016/j.jgr.2024.12.007","url":null,"abstract":"<div><h3>Background</h3><div><em>Panax ginseng</em> fruit tissue is one of the richest sources of valuable constituents such as ginsenosides and anthocyanins. Although anthocyanins extracted from the fruit tissue of <em>P. ginseng</em> are utilized, it is uncertain how anthocyanin accumulation is regulated and which anthocyanin varieties are synthesized.</div></div><div><h3>Methods</h3><div>Fruits of four <em>P. ginseng</em> cultivars were collected for total RNA extraction and RNA-Seq analysis using the Illumina HiSeq X platform. Anthocyanins were extracted and analyzed by UPLC-DAD-QToF/MS to identify and quantify individual derivatives. Differentially expressed genes (DEGs) were identified, followed by functional annotation and network analysis to evaluate gene expression patterns.</div></div><div><h3>Results</h3><div>Comparative transcriptome analysis of four differently colored <em>P. ginseng</em> cultivars revealed that flavonoid biosynthetic genes associated with the karrikin response and jasmonate-responsive genes were upregulated in anthocyanin-rich fruits. Network analysis further revealed a putative regulatory complex consists of karrikin- and jasmonate-responsive genes along with flavonoid biosynthetic genes. Analyzing the UPLC-DAD extracts of the fruit of cv. Chunpoong found that the fruit tissue of <em>P. ginseng</em> is rich in pelargonidin.</div></div><div><h3>Conclusion</h3><div>Our research provides how anthocyanin is accumulated and which type is accumulated in fruit tissue of <em>P. ginseng,</em> including the original compound, pelargonidin 3-O-(2″-O-glucosyl)galactoside. We expect that our research will lead to improved breeding efficiency for the development of cultivars containing more flavonoid species that are beneficial to humans.</div></div>","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":"49 3","pages":"Pages 315-325"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of skin regeneration through activation of TGF-β/SMAD signaling pathway by Panax ginseng meyer non-edible callus-derived extracellular vesicles","authors":"Ha Young Park ,&nbsp;Min Ho Kang ,&nbsp;Guewha Lee ,&nbsp;Jin Woo Kim","doi":"10.1016/j.jgr.2024.08.002","DOIUrl":"10.1016/j.jgr.2024.08.002","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the effects of ginseng non-edible callus-derived extracellular vesicle (GNEV) on skin regeneration, particularly focusing on its impact on proliferation and migration in human dermal fibroblast (HDF).</div></div><div><h3>Methods</h3><div>GNEV was isolated from ginseng non-edible callus using sequential filtration and size exclusion chromatography (SEC). The extracellular vesicle was characterized using nanoparticle tracking analysis (NTA). HDF was treated with various concentrations of GNEV, and cell viability, proliferation, and migration were assessed using MTT and scratch wound healing assays. Gene expression related to collagen synthesis (<em>TGF-β, SMAD-2, SMAD-3, COL1A1</em>) was measured using RT-PCR.</div></div><div><h3>Results</h3><div>Treatment of HDF with GNEV resulted in a significant 2.5-fold increase in cell migration compared to the non-treated group. Furthermore, GNEV demonstrated the upregulation of collagen synthesis genes, specifically <em>TGF-β, SMAD-2, SMAD-3</em>, and <em>COL1A1</em>, by 41.7 %, 59.4 %, 60.2 %, and 21.8 %, respectively. These findings indicated that GNEV activates the <em>TGF-β/SMAD</em> signaling pathway, showcasing its potential to induce skin regeneration.</div></div><div><h3>Conclusions</h3><div>In conclusion, GNEV exhibits a notable ability to enhance skin regeneration through its stimulatory effects on cell migration and the upregulation of key collagen synthesis genes. The activation of the <em>TGF-β/SMAD</em> signaling pathway further suggests the potential of GNEV as a promising candidate for drug delivery systems in the fields of cosmetics and pharmaceuticals, opening avenues for further research and application in skincare and dermatology.</div></div>","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":"49 1","pages":"Pages 34-41"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the DNA damage response (DDR) of cancer cells with natural compounds derived from Panax ginseng and other plants","authors":"SeokGyeong Choi ,&nbsp;Minwook Shin ,&nbsp;Woo-Young Kim","doi":"10.1016/j.jgr.2024.04.001","DOIUrl":"10.1016/j.jgr.2024.04.001","url":null,"abstract":"<div><div>DNA damage is a driver of cancer formation, leading to the impairment of repair mechanisms in cancer cells and rendering them susceptible to DNA-damaging therapeutic approaches. The concept of “synthetic lethality” in cancer clinics has emerged, particularly with the use of PARP inhibitors and the identification of DNA damage response (DDR) mutation biomarkers, emphasizing the significance of targeting DDR in cancer therapy. Novel approaches aimed at genome maintenance machinery are under development to further enhance the efficacy of cancer treatments. Natural compounds from traditional medicine, renowned for their anti-aging and anticarcinogenic properties, have garnered attention. Ginseng-derived compounds, in particular, exhibit anti-carcinogenic effects by suppressing reactive oxygen species (ROS) and protecting cells from DNA damage-induced carcinogenesis. However, the anticancer therapeutic effect of ginseng compounds has also been demonstrated by inducing DNA damage and blocking DDR. This review concentrates on the biphasic effects of ginseng compounds on DNA mutations—both inhibiting mutation accumulation and impairing DNA repair. Additionally, it explores other natural compounds targeting DDR directly, providing potential insights into enhancing cancer therapy efficacy.</div></div>","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":"49 1","pages":"Pages 1-11"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140625759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compositional changes and physiological activities of fresh ginseng extracts prepared at various temperatures in subcritical water","authors":"Jong Won Lee ,&nbsp;Mi-Yeon Lee ,&nbsp;SangYoon Lee ,&nbsp;Geun-Pyo Hong","doi":"10.1016/j.jgr.2024.09.007","DOIUrl":"10.1016/j.jgr.2024.09.007","url":null,"abstract":"<div><h3>Background</h3><div>Subcritical water (SW) is regarded as an effective conversion technology for lignocellulosic biomass. The effect of SW on ginseng are limited to evaluate the ginsenoside composition of red ginseng, and there is little information on the effects of SW on fresh ginseng.</div></div><div><h3>Methods</h3><div>The general characteristics of ginseng extracts (GE) prepared with SW were evaluated in terms of brix, reducing sugar and residual solid content, and compositions of GE was estimated using chromatography. For utilization of GE as a bioactive food, the ginsenoside composition, antioxidative activity, angiotensin-converting enzyme (ACE) inhibitory activity, prebiotic potential and taste attributes were measured.</div></div><div><h3>Results</h3><div>Increasing SW temperature decreased residual solid content of ginseng and the soluble compounds of GE were yielded by SW at 250 °C. Despite that ginsenoside content decreased with SW temperature, a steep increase in Rg5 was observed at 200 °C. The SW at 200–250 °C manifested the highest antioxidant activities and ACE inhibitory activity of GE. However, the GE prepared at greater than 250 °C completely lost prebiotic potentials. Based on electronic-tongue, umami taste was enhanced by SW at 200 °C, but sweetness and bitterness were dominated at 250–300 °C.</div></div><div><h3>Conclusion</h3><div>The results demonstrated that SW has a potential application to convert lignocellulosic wastes generated from ginseng roots into bioactive food resource, and SW at ∼200 °C can be potentially used to enhance the physiological activities of GE.</div></div>","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":"49 1","pages":"Pages 64-70"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Korean red ginseng on auditory, cognitive, and liver functions in a naturally aged mouse model","authors":"Sung Woo Shin ,&nbsp;Ji Heon Shim ,&nbsp;Youn Hee Nam ,&nbsp;Na Woo Kim ,&nbsp;Gyeong Jin Seo ,&nbsp;Murughanantham Nevedita ,&nbsp;Pandian Subha ,&nbsp;Quy-Hoai Nguyen ,&nbsp;Yong Su Jeong ,&nbsp;Bin Na Hong ,&nbsp;Tong Ho Kang","doi":"10.1016/j.jgr.2024.10.001","DOIUrl":"10.1016/j.jgr.2024.10.001","url":null,"abstract":"<div><h3>Background</h3><div>Korean Red Ginseng and ginsenosides have been studied for their efficacy against various diseases, including those related to aging. However, most aging studies use D-galactose to induce aging, which often does not accurately represent natural aging. This study aimed to verify improvements in auditory, cognitive, and liver function through administering red ginseng to an 18-month-old naturally aging mouse model.</div></div><div><h3>Methods</h3><div>Auditory function was assessed using Auditory Brainstem Response (ABR) and Auditory Middle Latency Response (AMLR). Cognitive function was evaluated electrophysiologically with P300 and mismatch negativity (MMN), and behaviorally using the Y-maze. Additionally, biochemical tests and histological analysis were conducted to assess liver function. The effects of red ginseng on gene expression regulation were also examined in the cochlea, auditory cortex, and liver, focusing on age-related disease processes.</div></div><div><h3>Results</h3><div>Red ginseng significantly decreased hearing thresholds and improved central auditory function. It also enhanced cognitive behavior and function in response to external stimulation. Furthermore, red ginseng regulated alkaline phosphatase (ALP), albumin (Alb), and total protein (TP) levels, notably decreasing aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Hematoxylin and eosin (H&amp;E) staining of liver tissue showed significant improvement in fat droplets. These effects appear to be mediated by the regulation of aging-related genes <em>Dec</em>, <em>c-Jun</em>, <em>Stat5b</em>, and <em>Lims2</em>.</div></div><div><h3>Conclusion</h3><div>These results suggest that red ginseng improves auditory, cognitive, and liver functions in a naturally aged mouse model.</div></div>","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":"49 1","pages":"Pages 71-79"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}