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Electrofusion Device With High-Aspect-Ratio Electrodes for the Controlled Fusion of Lipid Vesicles 用于脂质囊泡控制融合的高纵横比电极电融合装置
IF 2.5 3区 工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-02-10 DOI: 10.1109/JMEMS.2025.3530466
Tsutomu Okita;Mamiko Tsugane;Kosuke Kato;Keisuke Shinohara;Hiroaki Suzuki
Giant liposomes or giant vesicles have been used as dynamic bioreactors because of their ability to fuse with other vesicles to mix their contents. Among various principles, electrofusion is particularly useful because it is quick and does not require solution exchange. In conventional vesicle fusion methods, quantitative evaluation of fusion events has often been difficult because vesicles float and move due to the unexpected flow. In this study, we developed a microfluidic device equipped with microchambers for structural trapping and electrodes for vesicle fusion, in which the fusion phenomenon can be observed in definite locations. Specifically, we fabricated an electrofusion device that had conductive silicon electrodes and PDMS microchambers that held giant unilamellar vesicles (GUVs; diameter $gt 6~mu $ m) in place. The fusion yield of GUV-GUV and GUV-small GUV (diameter $lt 2~mu $ m) was examined by detecting the fluorescence marker that appeared upon the mixing of internal contents of two vesicle populations. This architecture can be used to realize parallel electrofusion assays for quantitatively analyzing biochemical reactions in the cell-mimetic environment. [2024-0166]
由于巨脂质体或巨囊泡能够与其他囊泡融合以混合其内容物,因此已被用作动态生物反应器。在各种原理中,电熔合尤其有用,因为它快速且不需要交换溶液。在传统的囊泡融合方法中,由于囊泡由于意外流动而漂浮和移动,通常难以对融合事件进行定量评估。在本研究中,我们开发了一种微流控装置,该装置配备了用于结构捕获的微室和用于囊泡融合的电极,可以在确定的位置观察到融合现象。具体来说,我们制造了一种电融合装置,它具有导电硅电极和PDMS微室,可以容纳巨大的单层囊泡(GUVs;直径$gt 6~ $ mu $ m)到位。通过检测两个囊泡群体内部内容物混合后出现的荧光标记,检测GUV-GUV和GUV-小GUV(直径$lt 2~mu $ m)的融合率。该结构可用于实现平行电融合分析,定量分析模拟细胞环境中的生化反应。(2024 - 0166)
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引用次数: 0
Corrections to “Parallel In-Plane Electrothermal Actuators” 修正“平行平面内电热致动器”
IF 2.5 3区 工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-02-04 DOI: 10.1109/JMEMS.2025.3528660
Yen Nee Ho;Aron Michael;Chee Yee Kwok;Cibby Pulikkaseril
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引用次数: 0
Journal of Microelectromechanical Systems Publication Information 微机电系统出版信息学报
IF 2.5 3区 工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-02-04 DOI: 10.1109/JMEMS.2024.3523667
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引用次数: 0
Bidirectional Thermo-Acoustic Modulator Based on LiNbO₃ Thin Film 基于LiNbO₃薄膜的双向热声调制器
IF 2.5 3区 工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-01-30 DOI: 10.1109/JMEMS.2024.3510540
Xuankai Xu;Yushuai Liu;Tao Wu
This letter presents a bidirectional thermo-acoustic (TA) modulator utilizing Y36-cut LiNbO $_{mathbf {3}}$ thin film. The device integrates two TA phase modulators and a one-dimensional (1D) phase-control transducer within a compact footprint of less than 0.35 mm2. The suspended LN thin film TA phase modulator demonstrates a phase response of 17°/mW. The composed TA amplitude modulator supports bidirectional amplitude modulation, achieving over 30 dB modulation at 460 MHz with a control voltage of 1.1 V. This compact and efficient design makes it ideal for phononic integrated circuit (PnIC) and advanced acoustic signal processing applications. [2024-0162]
本文介绍了一种利用Y36-cut LiNbO $_{mathbf{3}}$薄膜的双向热声(TA)调制器。该器件集成了两个TA相位调制器和一个一维(1D)相位控制传感器,占地面积小于0.35 mm2。悬浮LN薄膜TA相位调制器的相位响应为17°/mW。组成的TA调幅器支持双向调幅,在460 MHz下实现超过30 dB的调制,控制电压为1.1 V。这种紧凑而高效的设计使其成为声子集成电路(PnIC)和先进声学信号处理应用的理想选择。(2024 - 0162)
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引用次数: 0
Sensing Voltage at Electrically Floating Nodes: A Path Toward Enhancing Performance and Robustness in Capacitive MEMS Resonators 电浮节点感应电压:电容式MEMS谐振器增强性能和稳健性的途径
IF 2.5 3区 工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-01-23 DOI: 10.1109/JMEMS.2025.3528762
Disha Chugh;Hyun-Keun Kwon;Gabrielle D. Haddon-Vukasin;Thomas W. Kenny;Saurabh A. Chandorkar
Capacitively transduced micromechanical resonators for timing reference applications are overwhelmingly measured from the current output at their sensing electrodes, using a transimpedance amplifier (TIA). Continuous time floating-voltage measurement in capacitive resonators has not found its reach due to various reasons, the primary drawback being picking up of stray charges through stray/unknown capacitances linked to the electrically floating electrode. In this paper, we introduce a novel concept of bias tuning electrodes which alleviates this issue. Through theoretical modelling and experimental evidence, we show that voltage measurement performed at electrically-floating sensing-electrode using a voltage-amplifier (VA) is superior to TIA topology in terms of robustness, noise performance, and bandwidth. Furthermore, we introduce a new electrical circuit equivalent model for resonator devices with a bias tuning electrode in lieu of the standard Mason and Butterworth-Van Dyke (BVD) models which are unsuitable for our new topology. This new model also offers better insights for the combined system of resonator and sensing-unit. The theoretical and experimental work was carried out using a Epi-seal encapsulated DETF device wherein the superior performance of VA topology in key parameters and equivalent performance in other measures is demonstrated. This work is readily extendable to any general capacitively transduced device.[2024-0156]
用于时序参考应用的电容式微机械谐振器,绝大多数是使用跨阻放大器(TIA)从其传感电极的电流输出进行测量的。由于各种原因,容性谐振器的连续时间浮电压测量尚未达到,主要缺点是通过与电浮电极相连的杂散/未知电容拾取杂散电荷。在本文中,我们引入了一种新的偏置调谐电极的概念,以缓解这一问题。通过理论建模和实验证据,我们表明使用电压放大器(VA)在电浮传感电极上进行的电压测量在鲁棒性,噪声性能和带宽方面优于TIA拓扑。此外,我们引入了一种新的电路等效模型,用于具有偏置调谐电极的谐振器器件,以取代不适合我们的新拓扑的标准Mason和Butterworth-Van Dyke (BVD)模型。这种新模型也为谐振器和传感单元的组合系统提供了更好的见解。利用Epi-seal封装的DETF器件进行了理论和实验工作,其中VA拓扑在关键参数上具有优越的性能,在其他指标上具有等效性能。这项工作很容易扩展到任何一般的电容传感装置。[2024-0156]
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引用次数: 0
Overcoming Welding and Contact Degradation Failures Incurred by Complementary N/MEMS Logic Gate Structures Fabricated on SOI Wafers 基于SOI晶圆的互补N/MEMS逻辑门结构焊接和接触退化失效的克服
IF 2.5 3区 工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-01-17 DOI: 10.1109/JMEMS.2025.3526543
Bennett Smith;Md Ataul Mamun;Benjamin Horstmann;Ümit Özgür;Vitaliy Avrutin
Nano/microelectromechanical systems (N/MEMS) based complementary logic circuits offer a physically robust alternative to conventional CMOS control systems, which are able to function in environments unsuitable for transistor devices. In this work we demonstrate novel, configurable, complementary logic circuits comprised entirely of relays at both NEMS and MEMS scale, which are capable of fulfilling all primary logic functions. Lifetime testing of the fabricated devices revealed two key failure modes: contact degradation and welding of high voltage cantilevers, both of which are caused by the charging and discharging of unwanted parasitic capacitances inherent to complementary relay structures. Devices are consequently damaged by high transient current and arc discharge between contacts. Several solutions are proposed and implemented to mitigate these issues, including minimization of unwanted capacitances, optimization of metallization scheme, introduction of intermediate operation cycles intended to increase time between state changes, and prevention of welding by preemptively charging capacitors to an intermediate voltage. To this effect, a detailed study of lifetimes for both single cantilevers and logic gate structures is presented comparing a variety of metallization schemes using Pt, Ti, TiN, and W, including their multilayer combinations. These varied optimization methods yielded single cantilever lifetimes of 1.74 billion cycles on average for devices with a Ti adhesion layer, a Pt primary layer, and a W surface layer to increase durability. Using the same metallization scheme, complementary logic structures achieved 0.6 million cycles on average. These results demonstrate the viability of robust N/MEMS based complementary logic circuits for safety critical control applications.[2024-0203]
基于纳米/微机电系统(N/MEMS)的互补逻辑电路为传统CMOS控制系统提供了物理上强大的替代方案,能够在不适合晶体管器件的环境中运行。在这项工作中,我们展示了新颖的,可配置的,互补的逻辑电路,完全由NEMS和MEMS规模的继电器组成,能够实现所有主要逻辑功能。器件的寿命测试揭示了两种主要失效模式:接触退化和高压悬臂的焊接,这两种失效模式都是由互补继电器结构固有的不必要寄生电容的充放电引起的。因此,触点之间的高瞬态电流和电弧放电会损坏器件。提出并实施了几种解决方案来缓解这些问题,包括最小化不必要的电容,优化金属化方案,引入中间操作循环以增加状态变化之间的时间,以及通过将电容器预先充电到中间电压来防止焊接。为此,对单悬臂和逻辑门结构的寿命进行了详细的研究,比较了使用Pt, Ti, TiN和W的各种金属化方案,包括它们的多层组合。这些不同的优化方法使具有Ti粘附层、Pt初级层和W表面层的器件的单悬臂寿命平均达到17.4亿次循环,以增加耐用性。使用相同的金属化方案,互补逻辑结构平均达到60万次循环。这些结果证明了基于N/MEMS的鲁棒互补逻辑电路在安全关键控制应用中的可行性。[2024-0203]
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引用次数: 0
Study of Stiction Mitigation in Micromachine Structures via Naphthalene Sublimation 通过萘升华缓解微机械结构中的粘滞问题研究
IF 2.5 3区 工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-01-17 DOI: 10.1109/JMEMS.2025.3527416
Hamed Nikfarjam;Sepehr Sheikhlari;Siavash Pourkamali
Micromachined devices are susceptible to stiction failure, where suspended structures irreversibly adhere due to surface forces. This paper investigates the effectiveness and reproducibility of simple, low-cost sublimation methods to reduce stiction using a saturated naphthalene-isopropyl alcohol (IPA) solution or molten naphthalene. Six categories of test structures were fabricated on silicon-on-insulator wafers, including narrow and wide cantilevers, clamped-clamped beams, parallel clamped-clamped beams, meandering beams, and suspended proof masses. We evaluated the effectiveness of air drying, IPA rinse, supercritical point drying (CPD), naphthalene-IPA solution, and molten naphthalene by identifying the longest and least stiff intact structure released for each method. Results showed that molten naphthalene outperformed CPD for wider structures, and reproducibility was confirmed over 10 repetitions per structure and method. These cost-effective, room-temperature techniques are well-suited for mitigating stiction in larger and softer structures, enhancing accessibility and availability for MEMS fabrication. [2024-0170]
微机械设备容易发生粘滞失效,其中悬浮结构由于表面力而不可逆转地粘附。本文研究了使用饱和萘-异丙醇(IPA)溶液或熔融萘的简单、低成本升华方法的有效性和可重复性。在绝缘体硅晶片上制作了六类测试结构,包括窄悬臂和宽悬臂、夹紧梁、平行夹紧梁、弯曲梁和悬挂防块。我们评估了空气干燥、IPA漂洗、超临界点干燥(CPD)、萘-IPA溶液和熔融萘的有效性,通过确定每种方法释放的最长和最不僵硬的完整结构。结果表明,熔融萘在更宽的结构上优于CPD,并且每种结构和方法的重复性超过10次。这些具有成本效益的室温技术非常适合于减轻较大和较软结构的粘滞,提高MEMS制造的可及性和可用性。(2024 - 0170)
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引用次数: 0
Activation Model of Nano Getter for MEMS Devices Based on Sandwich Structures of Au-Porous Ti-Dense Ti Film 基于au多孔Ti-致密Ti膜夹层结构的MEMS器件纳米吸气剂活化模型
IF 2.5 3区 工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-01-16 DOI: 10.1109/JMEMS.2025.3526153
Haowen Hu;Zhiyu Sun;Chenzhe Du;Qiancheng Zhao;Yufeng Jin;Jian Cui
Ti-based nano Nonevaporable getters (NEGs) have become essential materials for maintaining a long-term high vacuum in Micro-Electro-Mechanical System (MEMS) devices. However, it is still a confusing issue how to select the annealing temperature and time for the getter activation on the basis of the required activation level, excessive temperature and time will damage the MEMS devices inside the package. Therefore, the relationship between the activation temperature, activation time and activation level gains more attention since it can give guidance for the vacuum packaging process, which currently lacks an effective quantitative model to be followed. This paper introduces a simple and efficacious model for determining the activation parameters according to Fick’s diffusion law and reports a sandwich getter with an ‘Au-Porous Ti-Dense Ti’ structure based on this model to improve the getter performances. Experimental results indicate that ~50% activation level is achieved for a 3mm $times 3$ mm sandwich-style getter with 2 hours of 300°C annealing, which is expected to enable a high vacuum for a $1mu $ L microcavity up to 12 years. These results show close agreement with the model, proving to be valuable for optimizing the recipe of getter activation and providing an efficient way to prevent MEMS device failures.[2024-0165]
钛基纳米不可蒸发吸收体(NEGs)已成为微机电系统(MEMS)器件中保持长期高真空的重要材料。然而,如何根据所需的激活水平选择getter激活的退火温度和时间仍然是一个令人困惑的问题,过高的温度和时间会损坏封装内的MEMS器件。因此,活化温度、活化时间和活化水平之间的关系受到更多的关注,因为它可以指导真空包装工艺,目前缺乏一个有效的定量模型可以遵循。本文介绍了一种简单有效的根据菲克扩散定律确定活化参数的模型,并在此基础上设计了一种具有“au -多孔Ti-致密Ti”结构的夹层吸气剂,以提高吸气剂的性能。实验结果表明,在300℃退火2小时的情况下,3mm × 3mm的三明治式吸气器达到了50%的活化水平,有望实现1 μ L微腔长达12年的高真空。这些结果与模型非常吻合,证明了对优化getter激活配方的价值,并提供了一种有效的方法来防止MEMS器件故障。[2024-0165]
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引用次数: 0
Modeling Temperature Effects in a MEMS Ring Gyroscope: Toward Physics-Aware Drift Compensation 模拟 MEMS 环形陀螺仪的温度效应:实现物理感知漂移补偿
IF 2.5 3区 工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-01-15 DOI: 10.1109/JMEMS.2024.3524796
Mehran Hosseini-Pishrobat;Erdinc Tatar
Temperature plays an indispensable role in the long-term performance of MEMS gyroscopes, and despite extensive studies in the literature, analytical treatment of temperature effects is still an open problem. This paper, to the best of our knowledge, is the first attempt to address this gap for ring gyroscopes. We start with a superposition principle that disentangles thermal displacement fields from the gyroscope’s nominal vibration. We set forth a geometrically nonlinear variational formulation to obtain the temperature-induced stiffness matrix. We conduct temperature tests on our 3.2 mm-diameter, 58 kHz ring gyroscopes equipped with 16 capacitive stress sensors. The experimental data validate our analytical modeling in the following key aspects: 1) The model accounts for not only changes in material properties but also a less explored factor, thermal stresses. Thanks to a strain interpolation module that leverages the measured stresses, the model predicts frequency variations consistently and captures hysteresis loops arising from residual stresses. Notably, we accurately estimate the deviation of the temperature coefficient of frequency (TCF) from the expected value −30 ppm/°C (based on the widely known −60 ppm/°C dependency of Young’s modulus of silicon). 2) The model is able to capture stiffness couplings in the orders of less than 0.1 N/m (in a 7 kN/m device) and closely predicts the quadrature error and its leakage into the in-phase channel. Additionally, the model incorporates temperature variations of mechanical scale factor, drive mode’s amplitude, damping coupling, and sense mode’s phase in terms of their contribution to the in-phase error. Based on these merits, our model serves as a building block toward drift compensation algorithms encompassing the underlying physics of the temperature effects. [2024-0163]
温度在MEMS陀螺仪的长期性能中起着不可或缺的作用,尽管在文献中进行了广泛的研究,但温度效应的分析处理仍然是一个悬而未决的问题。这篇论文,据我们所知,是第一次尝试解决这一差距的环形陀螺仪。我们从一个叠加原理开始,将热位移场从陀螺仪的标称振动中分离出来。我们提出了一个几何非线性变分公式来获得温度诱导刚度矩阵。我们在直径3.2毫米、58千赫的环形陀螺仪上进行温度测试,陀螺仪配备了16个电容性应力传感器。实验数据在以下几个关键方面验证了我们的分析模型:1)该模型不仅考虑了材料性能的变化,还考虑了一个较少探索的因素,即热应力。由于应变插值模块可以利用测量的应力,该模型可以一致地预测频率变化,并捕获由残余应力引起的滞后回路。值得注意的是,我们准确地估计了频率温度系数(TCF)与期望值- 30 ppm/°C的偏差(基于众所周知的硅的杨氏模量的- 60 ppm/°C依赖性)。2)该模型能够捕获小于0.1 N/m量级的刚度耦合(在7 kN/m的设备中),并能很好地预测正交误差及其向同相通道的泄漏。此外,该模型还考虑了机械比例因子、驱动模式振幅、阻尼耦合和感知模式相位对同相误差的贡献。基于这些优点,我们的模型可以作为包含温度效应的底层物理的漂移补偿算法的构建块。(2024 - 0163)
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引用次数: 0
Turnover Temperature Point Adjustment in Mechanically Coupled Single-Crystal Silicon MEMS Resonators 机械耦合单晶硅MEMS谐振器的翻转温度点调节
IF 2.5 3区 工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-01-13 DOI: 10.1109/JMEMS.2024.3524384
Yuhao Xiao;Jinzhao Han;Bowen Li;Guoqiang Wu
This paper presents an effective approach for adjusting the zero temperature coefficient of frequency (turnover point) in mechanically coupled single-crystal silicon (SCS) microelectromechanical system (MEMS) resonators. The mechanically coupled MEMS resonators are fabricated on a heavily n-type doped SCS with a phosphorus doping concentration of around $1.0times 10^{20}$ cm $^ - 3 $ for achieving high turnover points. A turnover point tuning prediction model is derived, showing that the turnover point of mechanically coupled resonators can be represented as the weighted average sum of the product of the effective mass and the second order TCF of each individual resonator, along with its corresponding turnover point. By leveraging mechanical coupling between breathing-ring (BR) mode resonators and length-extensional (LE) or width-extensional (WE) mode resonators, the turnover point of mechanically coupled resonator can be purposely manipulated to above industrial temperature ranges by adjusting the dimensions of the coupled components. Such turnover temperatures can be employed in micro-oven-controlled MEMS oscillators (OCMOs) to achieve excellent frequency stability. The results offer valuable insights into optimizing the frequency-temperature characteristic of MEMS resonators in high-end timing field.[2024-0184]
本文提出了一种调整机械耦合单晶硅(SCS)微机电系统(MEMS)谐振器频率零温度系数(翻转点)的有效方法。机械耦合MEMS谐振器是在重n型掺杂的SCS上制造的,磷掺杂浓度约为1.0 × 10^{20}$ cm $^ - 3 $,以获得高周转点。推导了一个周转点调谐预测模型,表明机械耦合谐振器的周转点可表示为每个谐振器的有效质量与二阶TCF乘积的加权平均值及其对应的周转点。利用呼吸环(BR)模式谐振器与长伸(LE)或宽伸(WE)模式谐振器之间的机械耦合,通过调整耦合元件的尺寸,可以有意地将机械耦合谐振器的翻转点控制在工业温度范围以上。这样的翻转温度可以用于微烤箱控制的MEMS振荡器(OCMOs),以实现优异的频率稳定性。研究结果为优化MEMS谐振器的频率-温度特性提供了有价值的见解。[2024-0184]
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引用次数: 0
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Journal of Microelectromechanical Systems
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