Taro is plant that has a pseudostalk,cylindrical and light brown bulbs. The shape of leaf is the heart in length. Leaf stalk of taro contains are saponins, flavonoids, tanins, alkaloids, steroids and terpenoids. Leaf stalk of taro can be used as an alternative medicines wound and antioxidants. Flavonoids have an important role in the biological activity of taro leaf stalk. This research aims to determine the flavonoid and total flavonoids content in the taro leaf stalk extract. The extraction is done using maceration method with 70% ethanolas solvent. The extract which is got is used for qualitative and quantitative analysis. Quercetin used as a standard solution. Quantitative analysis using UV-Vis Spectrophotometry on a wavelength of 435.5 nm and operating time at the 29th minute. The results of qualitative test showed that the extract was positive flavonoids. The average concentrations of total flavonoids was 10,2223mg QE/gram extract with %CV value of 0,3051%.
{"title":"DETERMINATION of TOTAL FLAVONOID LEVELS on LEAF STALKS ETHANOL EXTRACT of TARO (Colocasia esculenta[L.]Schott)","authors":"Novena Yety Lindawati","doi":"10.37013/jf.v1i1.65","DOIUrl":"https://doi.org/10.37013/jf.v1i1.65","url":null,"abstract":"Taro is plant that has a pseudostalk,cylindrical and light brown bulbs. The shape of leaf is the heart in length. Leaf stalk of taro contains are saponins, flavonoids, tanins, alkaloids, steroids and terpenoids. Leaf stalk of taro can be used as an alternative medicines wound and antioxidants. Flavonoids have an important role in the biological activity of taro leaf stalk. This research aims to determine the flavonoid and total flavonoids content in the taro leaf stalk extract. The extraction is done using maceration method with 70% ethanolas solvent. The extract which is got is used for qualitative and quantitative analysis. Quercetin used as a standard solution. Quantitative analysis using UV-Vis Spectrophotometry on a wavelength of 435.5 nm and operating time at the 29th minute. The results of qualitative test showed that the extract was positive flavonoids. The average concentrations of total flavonoids was 10,2223mg QE/gram extract with %CV value of 0,3051%.","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77932629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elephantiasis (filariasis / elephantiasis) is still endemic in hundreds of districts in Indonesia and has become a health problem for the world community in accordance with the resolution of the World Health Assembly (WHA) in 1997. This is caused by Culex quinquefasciatus mosquitoes as one of many filariasis vectors found in urban areas (Gandahusada et al., 1998), while the number of filariasis chronic cases reported until 2009 was 11,914 cases. Filariasis / elephantiasisi is a chronic infectious disease caused by filarial worm infection transmitted by various types of mosquitoes in the lymph nodes, this disease is chronic (chronic) and if it does not get treatment can cause permanent disability in the form of enlargement of the legs, arms and genitals both women and men man. Rosmarin (Rosmarinus officinalis L.) is a multifunctional plant in Indonesia especially abroad, one of its benefits is as larvicides. Because rosmarin has a chemical compound, one of them is essential oil which has larvicidal effectiveness on Culex quinquefasciatus mosquito larvae as vector filariasis (elephantiasis) Essential oil was obtained by distillation of fresh rosmarin leaves, then each extract was made with 1000 ppm stock solution and then made 6 series of concentration of 12.5 ppm to 300 ppm then tested on 20 larvae of instar III Culex quinquefasciatus, Observations were made after 24 hours and calculated LC90 uses an analysis of the orbit. The results obtained were only essential oils of Rosmarin leaves (Rosmarinus officinalis L.) which had larvicidal activity against Culex quinquefasciatus mosquito larvae, with LC90 182,9756 ppm.
{"title":"UTILIZATION OF ROSMARIN LEAF OIL (Rosmarinus officinalis L) ON Culex Quinquefasciatus MOSQUITO LARVA AS A FILARIASIS VECTOR (ELEPHANT FOOT DISEASE)","authors":"D. Susilowati","doi":"10.37013/jf.v1i1.60","DOIUrl":"https://doi.org/10.37013/jf.v1i1.60","url":null,"abstract":"Elephantiasis (filariasis / elephantiasis) is still endemic in hundreds of districts in Indonesia and has become a health problem for the world community in accordance with the resolution of the World Health Assembly (WHA) in 1997. This is caused by Culex quinquefasciatus mosquitoes as one of many filariasis vectors found in urban areas (Gandahusada et al., 1998), while the number of filariasis chronic cases reported until 2009 was 11,914 cases. Filariasis / elephantiasisi is a chronic infectious disease caused by filarial worm infection transmitted by various types of mosquitoes in the lymph nodes, this disease is chronic (chronic) and if it does not get treatment can cause permanent disability in the form of enlargement of the legs, arms and genitals both women and men man. Rosmarin (Rosmarinus officinalis L.) is a multifunctional plant in Indonesia especially abroad, one of its benefits is as larvicides. Because rosmarin has a chemical compound, one of them is essential oil which has larvicidal effectiveness on Culex quinquefasciatus mosquito larvae as vector filariasis (elephantiasis) Essential oil was obtained by distillation of fresh rosmarin leaves, then each extract was made with 1000 ppm stock solution and then made 6 series of concentration of 12.5 ppm to 300 ppm then tested on 20 larvae of instar III Culex quinquefasciatus, Observations were made after 24 hours and calculated LC90 uses an analysis of the orbit. The results obtained were only essential oils of Rosmarin leaves (Rosmarinus officinalis L.) which had larvicidal activity against Culex quinquefasciatus mosquito larvae, with LC90 182,9756 ppm.","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"270 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75773071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Injuries are lost or damaged part of the body's tissues. Wounds are also defined as physical damage due to the opening or destruction of the skin which can cause abnormal skin function and anatomy. These plants widely used traditionally from fresh noni leaves used as a medicine for broken bones, cuts, burns and pain by boiling and drinking the juice. These studys to make use of more effective and efficient Noni leaf extract made in cream preparations as a wound medicine, so that people are easy to use. This study used an experimental research method, namely the cream formulation of noni concentrated ethanol extract of 5%, 10% and 15%. Cream preparation evaluation test included: Organoleptic, pH test, cream type test, homogeneity test, sticky power test, dispersion test and protection power test. The test method was carried out on mice by means of cream preparations applied to the back of mice which were given an incision wound. Its effectiveness is seen from the measurement of wound length for seven days to calculate the percentage of wound healing power. The results of the One Way ANOVA test showed that there were significant differences between concentrations of 5%, 10% and 15% with significant values <0.05. The percentage of healing power of noni leaf extract cream concentration of 5% = 7,69%, concentration of 10% = 17,26%, and concentration of 15% = 29,35%. The results showed that the ethanol extract of noni leaves can be made in cream dosage form and has the effectiveness to accelerate the healing of incision wounds in mice.
损伤是身体组织的一部分丢失或损坏。伤口也被定义为由于皮肤打开或破坏而造成的物理损伤，这可能导致皮肤功能和解剖结构异常。传统上，这些植物被广泛使用，从新鲜的诺丽叶中提取，通过煮沸和饮用汁液来治疗骨折、割伤、烧伤和疼痛。这些研究使诺丽叶提取物更有效、高效地制成乳膏制剂作为创面药，使人们易于使用。本研究采用实验研究方法，即乳膏配方中诺丽浓缩乙醇提取物的含量分别为5%、10%和15%。乳膏制剂评价试验包括:感官性试验、pH值试验、乳膏类型试验、均匀性试验、粘性试验、分散性试验和防护力试验。实验方法是将乳膏制剂涂于小鼠背部，并给予小鼠切口创面。通过测量伤口7天的长度来计算伤口愈合力的百分比，可以看出其有效性。单因素方差分析(One - Way ANOVA)结果显示，5%、10%和15%的浓度差异显著，且显著值<0.05。诺丽叶提取物乳膏浓度为5% = 7.69%，浓度为10% = 17.26%，浓度为15% = 29.35%。结果表明，诺丽叶乙醇提取物可制成乳膏剂型，具有促进小鼠切口伤口愈合的作用。
{"title":"FORMULATION DEVELOPMENT AND PHYSICAL TEST OF LEAF ETHANOL EXTRACT CREAM NONI (Morinda Citrifolia L) AS A WOUND HEALER","authors":"Anom Parmadi","doi":"10.37013/jf.v1i1.59","DOIUrl":"https://doi.org/10.37013/jf.v1i1.59","url":null,"abstract":"Injuries are lost or damaged part of the body's tissues. Wounds are also defined as physical damage due to the opening or destruction of the skin which can cause abnormal skin function and anatomy. These plants widely used traditionally from fresh noni leaves used as a medicine for broken bones, cuts, burns and pain by boiling and drinking the juice. These studys to make use of more effective and efficient Noni leaf extract made in cream preparations as a wound medicine, so that people are easy to use. This study used an experimental research method, namely the cream formulation of noni concentrated ethanol extract of 5%, 10% and 15%. Cream preparation evaluation test included: Organoleptic, pH test, cream type test, homogeneity test, sticky power test, dispersion test and protection power test. The test method was carried out on mice by means of cream preparations applied to the back of mice which were given an incision wound. Its effectiveness is seen from the measurement of wound length for seven days to calculate the percentage of wound healing power. The results of the One Way ANOVA test showed that there were significant differences between concentrations of 5%, 10% and 15% with significant values <0.05. The percentage of healing power of noni leaf extract cream concentration of 5% = 7,69%, concentration of 10% = 17,26%, and concentration of 15% = 29,35%. The results showed that the ethanol extract of noni leaves can be made in cream dosage form and has the effectiveness to accelerate the healing of incision wounds in mice.","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78391427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic Obstructive Pulmonary Disease (COPD) is one of the cause of mortality and morbidity in worldwide. This study aims to determine the pattern of treatment of bronchodilators with or without corticosteroids and their effects on changes carbon dioxide pressure in blood (PCO2) and oxygen pressure in blood (PO2) in COPD patients of inpatient in RSUD Dr. Moewardi Surakarta January 2016-June 2017. This research is a retrospective descriptive research design, data collecting by tracking medical records patients with 195 samples. The results showed that treatment of COPD patient using single bronchodilator of 30,8%, bronchodilator combination of 57,1%, bronchodilator combination with corticosteroid of 1% and corticosteroid equal to 91,3%.Effect of bronchodilator treatment without corticosteroids on changes in the largest largest PCO2 change of 14.8%, the smallest change in PCO25.9%, the largest PO2 change was 19%, the smallest PO2 change was 5.6%, whereas in patients who received bronchodilator treatment with corticosteroids there was the largest PCO2 change of 87.4%, the smallest PCO2 cha
{"title":"EVALUATION OF TREATMENT BRONCHODILATORS AND CORTICOSTEROIDS IN COPD INPATIENT IN HOSPITALS DR. MOEWARDI SURAKARTA JANUARY 2016-JUNE 2017","authors":"Lusia Murtisiwi","doi":"10.37013/jf.v1i1.67","DOIUrl":"https://doi.org/10.37013/jf.v1i1.67","url":null,"abstract":"Chronic Obstructive Pulmonary Disease (COPD) is one of the cause of mortality and morbidity in worldwide. This study aims to determine the pattern of treatment of bronchodilators with or without corticosteroids and their effects on changes carbon dioxide pressure in blood (PCO2) and oxygen pressure in blood (PO2) in COPD patients of inpatient in RSUD Dr. Moewardi Surakarta January 2016-June 2017. This research is a retrospective descriptive research design, data collecting by tracking medical records patients with 195 samples. The results showed that treatment of COPD patient using single bronchodilator of 30,8%, bronchodilator combination of 57,1%, bronchodilator combination with corticosteroid of 1% and corticosteroid equal to 91,3%.Effect of bronchodilator treatment without corticosteroids on changes in the largest largest PCO2 change of 14.8%, the smallest change in PCO25.9%, the largest PO2 change was 19%, the smallest PO2 change was 5.6%, whereas in patients who received bronchodilator treatment with corticosteroids there was the largest PCO2 change of 87.4%, the smallest PCO2 cha","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75806446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Babies born today will normally have an oval head shape because they have to pass through the birth canal. The size of the baby's head will continue to grow, because the baby's skull is still malleable, it is too long to spend time in one same position could lead to changes in the baby's head shape. Therefore, the optimal form of development that parents are very influential, namely in the patterns of parenting a newborn. Among infant sleep position, the use of baby bedding, baby feeding positions, baby's pillow. Determine the relation of parenting to the shape of the baby's head. This study is an sresearch observational withmethod. cross sectional The sampling technique used purposive sampling with 66 respondents. Data collected by filling the questionnaire and observation baby's head shape. The observations categorized by shape of the baby's head. Observations done on 66 respondents, ie 39 respondents have normocephaly head shape,15 respondents have plagiochepaly head shapes,6 respondents have scaphocephaly headshape,and 6 respondents have brachycephaly head shape.There is a relation parenting to the baby's head shape, including normocephaly, scaphocephaly, plagiocephaly, brachycephaly
{"title":"RELATIONSHIP BETWEEN PATTERNS FOR BABY'S HEAD","authors":"Agus Widodo","doi":"10.37013/jf.v1i1.63","DOIUrl":"https://doi.org/10.37013/jf.v1i1.63","url":null,"abstract":"Babies born today will normally have an oval head shape because they have to pass through the birth canal. The size of the baby's head will continue to grow, because the baby's skull is still malleable, it is too long to spend time in one same position could lead to changes in the baby's head shape. Therefore, the optimal form of development that parents are very influential, namely in the patterns of parenting a newborn. Among infant sleep position, the use of baby bedding, baby feeding positions, baby's pillow. Determine the relation of parenting to the shape of the baby's head. This study is an sresearch observational withmethod. cross sectional The sampling technique used purposive sampling with 66 respondents. Data collected by filling the questionnaire and observation baby's head shape. The observations categorized by shape of the baby's head. Observations done on 66 respondents, ie 39 respondents have normocephaly head shape,15 respondents have plagiochepaly head shapes,6 respondents have scaphocephaly headshape,and 6 respondents have brachycephaly head shape.There is a relation parenting to the baby's head shape, including normocephaly, scaphocephaly, plagiocephaly, brachycephaly","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79361826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lime (Citrus urantifolia) contains vitamin C and flavonoids which have antioxidant activity that can be used as a sunscreen. Antioxidants can repaire the effects of damage to human skin caused by free radicals which are the main factors in the aging process and damage to skin tissue. This purposes of this study were to determine the SPF value of ethanol extract of lime peel and lotion of lime peel extract. Firstly, lime fruit skin was extracted by remaceration method using 70% ethanol and followed by determination or SPF values, lotion formulated and tested for SPF values with UV-VIS Spectrophotometry.The results showed that SPF values of the ethanol extract of lime peel in various concentrations 100ppm, 150ppm, 200ppm, 250ppm and 300ppm were respectively 4.77 ± 0.12; 10.17 ± 0.01; 27.05 ± 0.02; 50.33 ± 0.18; 80.54 ± 0.49. The result showed that SPF value of lime ethanol extract sunscreen lotio in 300ppm was 80.54 ± 0.49. Ethanol extract of lime fruit skin has the potential as a sunscreen.
{"title":"THE SPF VALUE DETERMINATION OF EXTRACT AND SUNSCREEN LOTIO OF LIME RIND EXTRACT BY SPEKTROFOMETRI UV-VIS METHOD","authors":"S. Rejeki","doi":"10.37013/jf.v1i1.58","DOIUrl":"https://doi.org/10.37013/jf.v1i1.58","url":null,"abstract":"Lime (Citrus urantifolia) contains vitamin C and flavonoids which have antioxidant activity that can be used as a sunscreen. Antioxidants can repaire the effects of damage to human skin caused by free radicals which are the main factors in the aging process and damage to skin tissue. This purposes of this study were to determine the SPF value of ethanol extract of lime peel and lotion of lime peel extract. Firstly, lime fruit skin was extracted by remaceration method using 70% ethanol and followed by determination or SPF values, lotion formulated and tested for SPF values with UV-VIS Spectrophotometry.The results showed that SPF values of the ethanol extract of lime peel in various concentrations 100ppm, 150ppm, 200ppm, 250ppm and 300ppm were respectively 4.77 ± 0.12; 10.17 ± 0.01; 27.05 ± 0.02; 50.33 ± 0.18; 80.54 ± 0.49. The result showed that SPF value of lime ethanol extract sunscreen lotio in 300ppm was 80.54 ± 0.49. Ethanol extract of lime fruit skin has the potential as a sunscreen.","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87925286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saccharin is hundreds of times sweeter than sucrose, so that it can save production costs. Saccharin as a synthetic sweetener sugar substitute is very potential to be used in making sweet tasting foods that are sold at cheap prices in traditional market, one of which is red porridge. Many foods sold in traditional market are not accompanied by marketing permits as a home industry product, thus increasing the potential for saccharin abuse. This study aimed to determine the content of saccharin in red porridge sold in traditional market and to found out its suitability with the safe limits required in Regulation of the Head of the Food and Drug Supervisory Agency of the Republic Indonesia number 4 of 2014 concerning the maximum limit for the use of sweetener food additives. Identification of saccharin was carried out by resorcinol test and thin layer chromatography. Determination of saccharin was carried out by UV-Visible Spectrophotometric which had been validated at 267.5 nm. The results show that 9 samples of red porridge sold in traditional market contain saccharin with concentrations of 0.0154 – 0.0652 %, so that it exceeds the required safe limit of 0.0100 %. In the analysis method validation, selective method is obtained in the range of 20 – 60 μg/mL, with recovery 98.7371 %, coefficient of variation 0.8671%, coefficient of correlation 0.9993, limit of detection 1,9859 μg/mL, limit of quantitation 6.6197 μg/mL
{"title":"ANALYSIS OF SACCHARIN IN RED PORRIDGE FROM TRADITIONAL MARKET WHICH VALIDATED USING UVVISIBLE SPECTROPHOTOMETRIC","authors":"Crescentiana Emy Dhurhania, Asri Nur Hidayah","doi":"10.37013/jf.v1i1.66","DOIUrl":"https://doi.org/10.37013/jf.v1i1.66","url":null,"abstract":"Saccharin is hundreds of times sweeter than sucrose, so that it can save production costs. Saccharin as a synthetic sweetener sugar substitute is very potential to be used in making sweet tasting foods that are sold at cheap prices in traditional market, one of which is red porridge. Many foods sold in traditional market are not accompanied by marketing permits as a home industry product, thus increasing the potential for saccharin abuse. This study aimed to determine the content of saccharin in red porridge sold in traditional market and to found out its suitability with the safe limits required in Regulation of the Head of the Food and Drug Supervisory Agency of the Republic Indonesia number 4 of 2014 concerning the maximum limit for the use of sweetener food additives. Identification of saccharin was carried out by resorcinol test and thin layer chromatography. Determination of saccharin was carried out by UV-Visible Spectrophotometric which had been validated at 267.5 nm. The results show that 9 samples of red porridge sold in traditional market contain saccharin with concentrations of 0.0154 – 0.0652 %, so that it exceeds the required safe limit of 0.0100 %. In the analysis method validation, selective method is obtained in the range of 20 – 60 μg/mL, with recovery 98.7371 %, coefficient of variation 0.8671%, coefficient of correlation 0.9993, limit of detection 1,9859 μg/mL, limit of quantitation 6.6197 μg/mL","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90700345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Red yeast rice is one of thefoodstuff that contains flavonoid compounds which are useful as natural antioxidants. One attempt to overcome wrinkles is with antioxidants. The easy way to apply red yeast rice can be make in an extract that are formulated in cream preparations. This study aims to determine the antioxidant activities of Red yeast rice extract and its formulation in cream dosage form and the test of penetration and safety. Red yeast rice extract obtained by the method of maseration using ethanol 96% as a solvent. The cream is make in 3 formula, where the first formula as a negative control, second formula is cream of red yeast rice extract and third formula is cream of red yeast ricemicroemulsion. The antioxidant activity tested by DPPH method, the penetrationstrengthtested by Franz difussionmethod and the safety by primary and ocular irritation test.Research results demonstrated that red yeast rice extract had activity as antioxidant with the IC50 value was 2,60 ppm < 50 ppm (strong antioxidant) and microemulsion cream had penetrationstrength greater than red yeast rice extractcream. And the results of the primary irritation test showed that the cream is very little irritate and the results of the ocular irritation test cream does not irritate the eyes.
{"title":"ANTIOXIDANT ACTIVITY TEST OF THE RED YEAST RICE EXTRACT AND THE FORMULATION IN A CREAM PREPARATIONS ANDIT’S PENETRATION AND SAFETY TEST AT RABBIT","authors":"J. M. Peranginangin","doi":"10.37013/jf.v1i1.62","DOIUrl":"https://doi.org/10.37013/jf.v1i1.62","url":null,"abstract":"Red yeast rice is one of thefoodstuff that contains flavonoid compounds which are useful as natural antioxidants. One attempt to overcome wrinkles is with antioxidants. The easy way to apply red yeast rice can be make in an extract that are formulated in cream preparations. This study aims to determine the antioxidant activities of Red yeast rice extract and its formulation in cream dosage form and the test of penetration and safety. Red yeast rice extract obtained by the method of maseration using ethanol 96% as a solvent. The cream is make in 3 formula, where the first formula as a negative control, second formula is cream of red yeast rice extract and third formula is cream of red yeast ricemicroemulsion. The antioxidant activity tested by DPPH method, the penetrationstrengthtested by Franz difussionmethod and the safety by primary and ocular irritation test.Research results demonstrated that red yeast rice extract had activity as antioxidant with the IC50 value was 2,60 ppm < 50 ppm (strong antioxidant) and microemulsion cream had penetrationstrength greater than red yeast rice extractcream. And the results of the primary irritation test showed that the cream is very little irritate and the results of the ocular irritation test cream does not irritate the eyes.","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85724692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Corticosteroids was the mainstay therapy for SLE, an autoimmune chronic desease. Prolonged use of Corticosteroid caused many side effects’ risk. This study was aimed to evaluate corticosteroid drug use in SLE outpatients. This study was conducted on April 2017 to August 2017. Cross sectional design was used and presented with analytical descriptive. The result is, 192 SLE outpatients pass the inclusion criteria and 98,96% are women. Methylprednisolon per oral is the most corticosteroid used for SLE outpatients, combine with 1 other immnunsuppresant ( 65,10 %) and combine with 2 other immunsuppresant ( 8,33% ). From BMI, 26,05% subjects are overweight, perhaps because of corticosteroids side effect, such as weight gain. More than a half SLE outpatients (58,33%) get Calcium supplement and vitamin D3 as prophylactive for osteoporosis because of prolonged use of corticosteroid and 61 SLE outpatients get drug for gastrointestinal use to avoid peptic ulcer. There are 44 cases of potential corticosteroid interaction with other drug that are given together, the most are corticosteroid and aspirin interaction, on 14 patients.
{"title":"DRUG USE EVALUATION OF CORTICOSTEROIDSIN SYSTEMIC LUPUS ERYTHEMATOSUS OUTPATIENTS","authors":"M. N.Setiawati","doi":"10.37013/jf.v1i1.57","DOIUrl":"https://doi.org/10.37013/jf.v1i1.57","url":null,"abstract":"Corticosteroids was the mainstay therapy for SLE, an autoimmune chronic desease. Prolonged use of Corticosteroid caused many side effects’ risk. This study was aimed to evaluate corticosteroid drug use in SLE outpatients. This study was conducted on April 2017 to August 2017. Cross sectional design was used and presented with analytical descriptive. The result is, 192 SLE outpatients pass the inclusion criteria and 98,96% are women. Methylprednisolon per oral is the most corticosteroid used for SLE outpatients, combine with 1 other immnunsuppresant ( 65,10 %) and combine with 2 other immunsuppresant ( 8,33% ). From BMI, 26,05% subjects are overweight, perhaps because of corticosteroids side effect, such as weight gain. More than a half SLE outpatients (58,33%) get Calcium supplement and vitamin D3 as prophylactive for osteoporosis because of prolonged use of corticosteroid and 61 SLE outpatients get drug for gastrointestinal use to avoid peptic ulcer. There are 44 cases of potential corticosteroid interaction with other drug that are given together, the most are corticosteroid and aspirin interaction, on 14 patients.","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"57 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91498726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tamarind is a medicinal plant that has benefits as an antiseptic, antipyretic and analgetic (anti-pain). Pain is an unpleasant sensory and emotional experience due to actual or potential damage.The purpose thisstudy to determine the optimal analgetic and dosage activity of tamarind leaf ethanol extract on male mice swiss strain induced by acetic acid. The method used is analysis of results by observing the amount of stretching of mice every five minutes for an hour. The cumulative amount of stretching in mice to calculate the analgetic activity was obtained from the amount of stretching of mice induced by acetid acid intraperitoneally within 30 minutes after orally induced. Statistical analgetic data using kolmogorov-smirnov normality test, test of homogenity of variances followed by Anova test and post hoc tests using SPSS 24.0 for windows. Percentanalgesic activity of ethanol extract of leaves tamarind dosage 5%, 10%, 20%wererespectively (9,81 ± 2,24)%, (24,68 ± 2,10)% and (36,39 ± 3,06)%. Ethanol extract of leaves tamarind dosage 20% provide the most optimal activity analgesic
{"title":"ANALGETICACTIVITY TEST OF ETHANOL EXTRACT OFTAMARIND LEAVES (TamarindusIndica L.) TO MALEMICE OF SWISS STRAIN","authors":"S. Wahyuningsih","doi":"10.37013/jf.v1i1.61","DOIUrl":"https://doi.org/10.37013/jf.v1i1.61","url":null,"abstract":"Tamarind is a medicinal plant that has benefits as an antiseptic, antipyretic and analgetic (anti-pain). Pain is an unpleasant sensory and emotional experience due to actual or potential damage.The purpose thisstudy to determine the optimal analgetic and dosage activity of tamarind leaf ethanol extract on male mice swiss strain induced by acetic acid. The method used is analysis of results by observing the amount of stretching of mice every five minutes for an hour. The cumulative amount of stretching in mice to calculate the analgetic activity was obtained from the amount of stretching of mice induced by acetid acid intraperitoneally within 30 minutes after orally induced. Statistical analgetic data using kolmogorov-smirnov normality test, test of homogenity of variances followed by Anova test and post hoc tests using SPSS 24.0 for windows. Percentanalgesic activity of ethanol extract of leaves tamarind dosage 5%, 10%, 20%wererespectively (9,81 ± 2,24)%, (24,68 ± 2,10)% and (36,39 ± 3,06)%. Ethanol extract of leaves tamarind dosage 20% provide the most optimal activity analgesic","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79276366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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