Pub Date : 2025-07-07DOI: 10.1038/s41579-025-01210-w
Ka-Wai Ma
In this Journal Club, Ka-Wai Ma discusses a paper that establishes that phenotypic heterogeneity and division of labour promote plant infection.
在本期刊中，马家伟讨论了一篇建立表型异质性和劳动分工促进植物侵染的论文。
{"title":"Coordinated action by individuals orchestrates infection through the division of labour","authors":"Ka-Wai Ma","doi":"10.1038/s41579-025-01210-w","DOIUrl":"10.1038/s41579-025-01210-w","url":null,"abstract":"In this Journal Club, Ka-Wai Ma discusses a paper that establishes that phenotypic heterogeneity and division of labour promote plant infection.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 9","pages":"549-549"},"PeriodicalIF":103.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1038/s41579-025-01207-5
Dilfuza Egamberdieva
As environmental and agricultural challenges intensify, raising awareness and developing innovative microbial solutions to improve crop yields, enhance soil quality, sequester carbon and reduce greenhouse gas emissions becomes not just a choice, but a mission, states Dilfuza Egamberdieva.
{"title":"Building climate-resilient agriculture through science and local action","authors":"Dilfuza Egamberdieva","doi":"10.1038/s41579-025-01207-5","DOIUrl":"10.1038/s41579-025-01207-5","url":null,"abstract":"As environmental and agricultural challenges intensify, raising awareness and developing innovative microbial solutions to improve crop yields, enhance soil quality, sequester carbon and reduce greenhouse gas emissions becomes not just a choice, but a mission, states Dilfuza Egamberdieva.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 8","pages":"469-470"},"PeriodicalIF":103.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-30DOI: 10.1038/s41579-025-01202-w
Huldrych F. Günthard, Katharina Kusejko, Roger D. Kouyos
Despite decades of research and medical advances, the HIV-1 pandemic still presents major public health challenges, with most countries failing to meet the defined targets for HIV elimination. HIV-1 is the first chronic viral disease for which extensive virus sequence data became available through genotypic resistance testing. Phylogenetic methods have been instrumental in answering pathogenesis-related questions, such as ongoing viral replication on antiretroviral therapy and the role of the viral genome in pathogenesis and immunity. Molecular data have also largely enabled the development and application of phylogenetic and molecular epidemiology approaches to large populations, providing unique insights. These insights include the origin and timing of the HIV-1 pandemic, its global spread, transmission dynamics within and between subpopulations, and quantifying the impact of public health interventions on ongoing transmission. Such knowledge is essential for improving our understanding of key epidemic dynamics at both the micro and macro levels, as well as of the underlying biological mechanisms. In the future, these insights could be provided in real time to guide and optimize prevention measures. Molecular public health approaches should be expanded, particularly in low-income and middle-income countries where most of the pandemic’s burden persists. In this Review, Günthard, Kusejko and Kouyos examine how advances in phylogenetics and molecular epidemiology have deepened our understanding of the HIV pandemic, including tracing its zoonotic origins, monitoring transmission dynamics and prevention efforts, and understanding pathogenesis.
{"title":"Phylogenetics and molecular evolution to understand and curb the HIV pandemic","authors":"Huldrych F. Günthard, Katharina Kusejko, Roger D. Kouyos","doi":"10.1038/s41579-025-01202-w","DOIUrl":"10.1038/s41579-025-01202-w","url":null,"abstract":"Despite decades of research and medical advances, the HIV-1 pandemic still presents major public health challenges, with most countries failing to meet the defined targets for HIV elimination. HIV-1 is the first chronic viral disease for which extensive virus sequence data became available through genotypic resistance testing. Phylogenetic methods have been instrumental in answering pathogenesis-related questions, such as ongoing viral replication on antiretroviral therapy and the role of the viral genome in pathogenesis and immunity. Molecular data have also largely enabled the development and application of phylogenetic and molecular epidemiology approaches to large populations, providing unique insights. These insights include the origin and timing of the HIV-1 pandemic, its global spread, transmission dynamics within and between subpopulations, and quantifying the impact of public health interventions on ongoing transmission. Such knowledge is essential for improving our understanding of key epidemic dynamics at both the micro and macro levels, as well as of the underlying biological mechanisms. In the future, these insights could be provided in real time to guide and optimize prevention measures. Molecular public health approaches should be expanded, particularly in low-income and middle-income countries where most of the pandemic’s burden persists. In this Review, Günthard, Kusejko and Kouyos examine how advances in phylogenetics and molecular epidemiology have deepened our understanding of the HIV pandemic, including tracing its zoonotic origins, monitoring transmission dynamics and prevention efforts, and understanding pathogenesis.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"24 1","pages":"76-92"},"PeriodicalIF":103.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-30DOI: 10.1038/s41579-025-01201-x
Digby F. Warner, Amy K. Barczak, Maximiliano G. Gutierrez, Valerie Mizrahi
Since the release of the first Mycobacterium tuberculosis genome in 1998, major advances have been made in understanding the biology of this pathogen, the leading infectious cause of death in modern human history. In this Review, we outline the physiological and metabolic features thought to underpin the survival, evasion and subversion strategies employed by M. tuberculosis as it drives a cycle of transmission, infection and disease in its obligate human host. We also consider adaptations to key host innate immune effectors, including the roles of granulocytes, phagosomal damage and repair, autophagy and cell death in determining host–mycobacterium outcomes. Given the increasing awareness of the importance of asymptomatic M. tuberculosis infection and transmission, we advocate for the need to ensure greater intersection between laboratory and clinical research, taking into account the environmental context in which natural infection and disease occur. We identify knowledge gaps in the field and reflect on the opportunities and challenges for integrating host, bacterium and environment into future investigations to inform intervention strategies to control tuberculosis disease. In this Review, Warner, Barczak, Gutierrez and Mizrahi explore essential aspects of Mycobacterium tuberculosis physiology and biology, present recent advances related to its pathogenesis, metabolism and immune evasion mechanisms, and propose future directions for research.
{"title":"Mycobacterium tuberculosis biology, pathogenicity and interaction with the host","authors":"Digby F. Warner, Amy K. Barczak, Maximiliano G. Gutierrez, Valerie Mizrahi","doi":"10.1038/s41579-025-01201-x","DOIUrl":"10.1038/s41579-025-01201-x","url":null,"abstract":"Since the release of the first Mycobacterium tuberculosis genome in 1998, major advances have been made in understanding the biology of this pathogen, the leading infectious cause of death in modern human history. In this Review, we outline the physiological and metabolic features thought to underpin the survival, evasion and subversion strategies employed by M. tuberculosis as it drives a cycle of transmission, infection and disease in its obligate human host. We also consider adaptations to key host innate immune effectors, including the roles of granulocytes, phagosomal damage and repair, autophagy and cell death in determining host–mycobacterium outcomes. Given the increasing awareness of the importance of asymptomatic M. tuberculosis infection and transmission, we advocate for the need to ensure greater intersection between laboratory and clinical research, taking into account the environmental context in which natural infection and disease occur. We identify knowledge gaps in the field and reflect on the opportunities and challenges for integrating host, bacterium and environment into future investigations to inform intervention strategies to control tuberculosis disease. In this Review, Warner, Barczak, Gutierrez and Mizrahi explore essential aspects of Mycobacterium tuberculosis physiology and biology, present recent advances related to its pathogenesis, metabolism and immune evasion mechanisms, and propose future directions for research.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 12","pages":"788-804"},"PeriodicalIF":103.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-30DOI: 10.1038/s41579-025-01195-6
Stephen J. Mondo, Igor V. Grigoriev
Originating from aquatic unicellular ancestors, over the course of ~1 billion years, the fungi have evolved to occupy nearly all aerobic environments on the planet, diversified into millions of different ‘species’ and have developed complex multicellular structures. Their relatively small, simple genomes have facilitated massive-scale sequencing and allowed us to explore genome evolution across an ancient eukaryotic kingdom. With thousands of genomes from diverse lineages now available, this Review will discuss insights into fungal biology and evolution gleaned with genomics and other multi-omics approaches. Using published genomes available through GenBank and the Joint Genome Institute’s MycoCosm platform, we generated kingdom-wide phylogenies and used them to highlight how fungal genomes have changed over time. With this phylogeny as a guide, we also discuss major evolutionary transitions that occurred across the fungal kingdom. Although progress has been made, these efforts are hampered by biases in genome representation and limited characterization of gene functions. Here, we discuss these challenges and possible future directions to address them, including initiatives to characterize conserved genes of unknown function and scale up sequencing towards 10,000 annotated fungal genomes. In this Review, Mondo and Grigoriev explore the central role of omics approaches to investigate the biology and evolution of fungi and understand phylogeny and how traits evolved over time within the fungal kingdom.
{"title":"A genomic perspective on fungal diversity and evolution","authors":"Stephen J. Mondo, Igor V. Grigoriev","doi":"10.1038/s41579-025-01195-6","DOIUrl":"10.1038/s41579-025-01195-6","url":null,"abstract":"Originating from aquatic unicellular ancestors, over the course of ~1 billion years, the fungi have evolved to occupy nearly all aerobic environments on the planet, diversified into millions of different ‘species’ and have developed complex multicellular structures. Their relatively small, simple genomes have facilitated massive-scale sequencing and allowed us to explore genome evolution across an ancient eukaryotic kingdom. With thousands of genomes from diverse lineages now available, this Review will discuss insights into fungal biology and evolution gleaned with genomics and other multi-omics approaches. Using published genomes available through GenBank and the Joint Genome Institute’s MycoCosm platform, we generated kingdom-wide phylogenies and used them to highlight how fungal genomes have changed over time. With this phylogeny as a guide, we also discuss major evolutionary transitions that occurred across the fungal kingdom. Although progress has been made, these efforts are hampered by biases in genome representation and limited characterization of gene functions. Here, we discuss these challenges and possible future directions to address them, including initiatives to characterize conserved genes of unknown function and scale up sequencing towards 10,000 annotated fungal genomes. In this Review, Mondo and Grigoriev explore the central role of omics approaches to investigate the biology and evolution of fungi and understand phylogeny and how traits evolved over time within the fungal kingdom.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 11","pages":"718-733"},"PeriodicalIF":103.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-26DOI: 10.1038/s41579-025-01208-4
Andrea Du Toit
This study shows that regional mismatches between transplanted microbiota and the host gut environment alter the metabolic and immune states of host tissues as well as the composition of regional microbiomes.
{"title":"A misplaced microbiome","authors":"Andrea Du Toit","doi":"10.1038/s41579-025-01208-4","DOIUrl":"10.1038/s41579-025-01208-4","url":null,"abstract":"This study shows that regional mismatches between transplanted microbiota and the host gut environment alter the metabolic and immune states of host tissues as well as the composition of regional microbiomes.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 8","pages":"472-472"},"PeriodicalIF":103.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-25DOI: 10.1038/s41579-025-01209-3
Andrea Du Toit
This study discovers that two distinct cryptic Pseudogymnoascus destructans species cause white-nose disease.
本研究发现两种不同的隐生破坏假裸子霉引起白鼻病。
{"title":"A long-lost species","authors":"Andrea Du Toit","doi":"10.1038/s41579-025-01209-3","DOIUrl":"10.1038/s41579-025-01209-3","url":null,"abstract":"This study discovers that two distinct cryptic Pseudogymnoascus destructans species cause white-nose disease.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 8","pages":"472-472"},"PeriodicalIF":103.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-11DOI: 10.1038/s41579-025-01203-9
Agustina Taglialegna
In a recent study, Sidhu et al. show that depletion of the pla virulence gene in Yersinia pestis ancient and modern pandemic strains reduced their virulence, thereby promoting the pathogen’s persistence and transmission.
{"title":"Persistence over virulence in Yersinia pestis","authors":"Agustina Taglialegna","doi":"10.1038/s41579-025-01203-9","DOIUrl":"10.1038/s41579-025-01203-9","url":null,"abstract":"In a recent study, Sidhu et al. show that depletion of the pla virulence gene in Yersinia pestis ancient and modern pandemic strains reduced their virulence, thereby promoting the pathogen’s persistence and transmission.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 8","pages":"471-471"},"PeriodicalIF":103.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-11DOI: 10.1038/s41579-025-01204-8
Agustina Taglialegna
In a recent study, Li et al. report microbial mechanisms that enhance plant adaptation to drought conditions.
在最近的一项研究中，Li等人报道了增强植物对干旱条件适应的微生物机制。
{"title":"Microbial allies in plant defence against drought","authors":"Agustina Taglialegna","doi":"10.1038/s41579-025-01204-8","DOIUrl":"10.1038/s41579-025-01204-8","url":null,"abstract":"In a recent study, Li et al. report microbial mechanisms that enhance plant adaptation to drought conditions.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 8","pages":"471-471"},"PeriodicalIF":103.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-30DOI: 10.1038/s41579-025-01198-3
Amy K. Winter, Spencer J. Fox
Measles vaccination rates fell during the COVID-19 pandemic and have yet to recover, fuelling large and disruptive outbreaks globally. Now, a substantial outbreak in the Americas threatens elimination status in the region. The US response, marked by mixed messaging and a retreat from global health leadership and partnerships, further jeopardizes progress that took decades to achieve.
{"title":"Measles is resurging in the Americas and the world is watching","authors":"Amy K. Winter, Spencer J. Fox","doi":"10.1038/s41579-025-01198-3","DOIUrl":"10.1038/s41579-025-01198-3","url":null,"abstract":"Measles vaccination rates fell during the COVID-19 pandemic and have yet to recover, fuelling large and disruptive outbreaks globally. Now, a substantial outbreak in the Americas threatens elimination status in the region. The US response, marked by mixed messaging and a retreat from global health leadership and partnerships, further jeopardizes progress that took decades to achieve.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 7","pages":"407-408"},"PeriodicalIF":103.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：