Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02951-5
Lin Tang
Virtual cells based on artificial intelligence models are on the horizon
基于人工智能模型的虚拟细胞即将出现
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Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02955-1
Nina Vogt
Extracellular recordings provide a wealth of information about neuronal activity but it is difficult to link this information to cell types.
细胞外记录提供了大量关于神经元活动的信息，但很难将这些信息与细胞类型联系起来。
{"title":"Cell typing by electrophysiology","authors":"Nina Vogt","doi":"10.1038/s41592-025-02955-1","DOIUrl":"10.1038/s41592-025-02955-1","url":null,"abstract":"Extracellular recordings provide a wealth of information about neuronal activity but it is difficult to link this information to cell types.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2495-2496"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02941-7
Moritz Helmstaedter
Connectomics has so far outpaced the Moore’s law predictions about technological progress. At this pace, many whole-brain connectomes and connectomic screening will soon be realistic.
{"title":"Optimism for abundant whole-brain connectomes and connectomic screening","authors":"Moritz Helmstaedter","doi":"10.1038/s41592-025-02941-7","DOIUrl":"10.1038/s41592-025-02941-7","url":null,"abstract":"Connectomics has so far outpaced the Moore’s law predictions about technological progress. At this pace, many whole-brain connectomes and connectomic screening will soon be realistic.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2490-2492"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02956-0
Lei Tang
Experimental and computational advances have improved enhancer characterization and design.
实验和计算的进步改进了增强子的特性和设计。
{"title":"Understanding enhancer logic through synthetic design","authors":"Lei Tang","doi":"10.1038/s41592-025-02956-0","DOIUrl":"10.1038/s41592-025-02956-0","url":null,"abstract":"Experimental and computational advances have improved enhancer characterization and design.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2494-2495"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02988-6
A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes of various organisms.
{"title":"Method of the Year 2025: electron microscopy-based connectomics","authors":"","doi":"10.1038/s41592-025-02988-6","DOIUrl":"10.1038/s41592-025-02988-6","url":null,"abstract":"A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes of various organisms.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2463-2464"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41592-025-02988-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02958-y
Lin Tang
Artificial intelligence agents may have a transformative effect on how biological research is performed.
人工智能代理可能会对生物研究的进行方式产生变革性的影响。
{"title":"Artificial intelligence agents for biology","authors":"Lin Tang","doi":"10.1038/s41592-025-02958-y","DOIUrl":"10.1038/s41592-025-02958-y","url":null,"abstract":"Artificial intelligence agents may have a transformative effect on how biological research is performed.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2496-2497"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02953-3
Madhura Mukhopadhyay
New technologies and computational approaches will illuminate the role of the cancer microbiome.
新技术和计算方法将阐明癌症微生物组的作用。
{"title":"Cracking the cancer microbiome","authors":"Madhura Mukhopadhyay","doi":"10.1038/s41592-025-02953-3","DOIUrl":"10.1038/s41592-025-02953-3","url":null,"abstract":"New technologies and computational approaches will illuminate the role of the cancer microbiome.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2494-2494"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02906-w
Vivien Marx
Using electron microscopy, scientists mapped a Caenorhabditis elegans nervous system and Drosophila brain at single-neuron resolution. Connectomics work on bigger brains takes new methods strategies.
{"title":"Method of the Year: EM connectomics","authors":"Vivien Marx","doi":"10.1038/s41592-025-02906-w","DOIUrl":"10.1038/s41592-025-02906-w","url":null,"abstract":"Using electron microscopy, scientists mapped a Caenorhabditis elegans nervous system and Drosophila brain at single-neuron resolution. Connectomics work on bigger brains takes new methods strategies.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2470-2475"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02949-z
Albert Lin, Mala Murthy
Detailed maps, or connectomes, of the fly brain and nervous system reveal how circuit architecture (wiring) shapes both neural activity and behavior. These maps already demonstrate that it is possible to predict function from structure, and provide the essential foundation for biologically realistic models of circuit function.
{"title":"Linking structure and function: biological insights from fly connectomes","authors":"Albert Lin, Mala Murthy","doi":"10.1038/s41592-025-02949-z","DOIUrl":"10.1038/s41592-025-02949-z","url":null,"abstract":"Detailed maps, or connectomes, of the fly brain and nervous system reveal how circuit architecture (wiring) shapes both neural activity and behavior. These maps already demonstrate that it is possible to predict function from structure, and provide the essential foundation for biologically realistic models of circuit function.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2476-2478"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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