Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02957-z
Lei Tang
Protein editors complement genome editing tools by enabling direct modifications to protein molecules.
蛋白质编辑器通过直接修改蛋白质分子来补充基因组编辑工具。
{"title":"Protein editing","authors":"Lei Tang","doi":"10.1038/s41592-025-02957-z","DOIUrl":"10.1038/s41592-025-02957-z","url":null,"abstract":"Protein editors complement genome editing tools by enabling direct modifications to protein molecules.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2496-2496"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02951-5
Lin Tang
Virtual cells based on artificial intelligence models are on the horizon
基于人工智能模型的虚拟细胞即将出现
{"title":"The virtual cell","authors":"Lin Tang","doi":"10.1038/s41592-025-02951-5","DOIUrl":"10.1038/s41592-025-02951-5","url":null,"abstract":"Virtual cells based on artificial intelligence models are on the horizon","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2493-2493"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02955-1
Nina Vogt
Extracellular recordings provide a wealth of information about neuronal activity but it is difficult to link this information to cell types.
细胞外记录提供了大量关于神经元活动的信息，但很难将这些信息与细胞类型联系起来。
{"title":"Cell typing by electrophysiology","authors":"Nina Vogt","doi":"10.1038/s41592-025-02955-1","DOIUrl":"10.1038/s41592-025-02955-1","url":null,"abstract":"Extracellular recordings provide a wealth of information about neuronal activity but it is difficult to link this information to cell types.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2495-2496"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02941-7
Moritz Helmstaedter
Connectomics has so far outpaced the Moore’s law predictions about technological progress. At this pace, many whole-brain connectomes and connectomic screening will soon be realistic.
{"title":"Optimism for abundant whole-brain connectomes and connectomic screening","authors":"Moritz Helmstaedter","doi":"10.1038/s41592-025-02941-7","DOIUrl":"10.1038/s41592-025-02941-7","url":null,"abstract":"Connectomics has so far outpaced the Moore’s law predictions about technological progress. At this pace, many whole-brain connectomes and connectomic screening will soon be realistic.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2490-2492"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02956-0
Lei Tang
Experimental and computational advances have improved enhancer characterization and design.
实验和计算的进步改进了增强子的特性和设计。
{"title":"Understanding enhancer logic through synthetic design","authors":"Lei Tang","doi":"10.1038/s41592-025-02956-0","DOIUrl":"10.1038/s41592-025-02956-0","url":null,"abstract":"Experimental and computational advances have improved enhancer characterization and design.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2494-2495"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02988-6
A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes of various organisms.
{"title":"Method of the Year 2025: electron microscopy-based connectomics","authors":"","doi":"10.1038/s41592-025-02988-6","DOIUrl":"10.1038/s41592-025-02988-6","url":null,"abstract":"A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes of various organisms.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2463-2464"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41592-025-02988-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02958-y
Lin Tang
Artificial intelligence agents may have a transformative effect on how biological research is performed.
人工智能代理可能会对生物研究的进行方式产生变革性的影响。
{"title":"Artificial intelligence agents for biology","authors":"Lin Tang","doi":"10.1038/s41592-025-02958-y","DOIUrl":"10.1038/s41592-025-02958-y","url":null,"abstract":"Artificial intelligence agents may have a transformative effect on how biological research is performed.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2496-2497"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02953-3
Madhura Mukhopadhyay
New technologies and computational approaches will illuminate the role of the cancer microbiome.
新技术和计算方法将阐明癌症微生物组的作用。
{"title":"Cracking the cancer microbiome","authors":"Madhura Mukhopadhyay","doi":"10.1038/s41592-025-02953-3","DOIUrl":"10.1038/s41592-025-02953-3","url":null,"abstract":"New technologies and computational approaches will illuminate the role of the cancer microbiome.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2494-2494"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41592-025-02906-w
Vivien Marx
Using electron microscopy, scientists mapped a Caenorhabditis elegans nervous system and Drosophila brain at single-neuron resolution. Connectomics work on bigger brains takes new methods strategies.
{"title":"Method of the Year: EM connectomics","authors":"Vivien Marx","doi":"10.1038/s41592-025-02906-w","DOIUrl":"10.1038/s41592-025-02906-w","url":null,"abstract":"Using electron microscopy, scientists mapped a Caenorhabditis elegans nervous system and Drosophila brain at single-neuron resolution. Connectomics work on bigger brains takes new methods strategies.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 12","pages":"2470-2475"},"PeriodicalIF":32.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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