Pub Date : 2025-12-08DOI: 10.1038/s41928-025-01510-2
Arnau Marin-Llobet, Jia Liu
A subdural device that merges electrodes and complementary metal–oxide–semiconductor (CMOS) circuits on a single ultrathin silicon chip could be used to create scalable, dense and fully wireless brain–computer interfaces.
{"title":"Wireless recording with ultrathin brain interfaces","authors":"Arnau Marin-Llobet, Jia Liu","doi":"10.1038/s41928-025-01510-2","DOIUrl":"10.1038/s41928-025-01510-2","url":null,"abstract":"A subdural device that merges electrodes and complementary metal–oxide–semiconductor (CMOS) circuits on a single ultrathin silicon chip could be used to create scalable, dense and fully wireless brain–computer interfaces.","PeriodicalId":19064,"journal":{"name":"Nature Electronics","volume":"8 12","pages":"1144-1145"},"PeriodicalIF":40.9,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145808776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41928-025-01509-9
Taesung Jung, Nanyu Zeng, Jason D. Fabbri, Guy Eichler, Zhe Li, Erfan Zabeh, Anup Das, Konstantin Willeke, Katie E. Wingel, Agrita Dubey, Rizwan Huq, Mohit Sharma, Yaoxing Hu, Girish Ramakrishnan, Kevin Tien, Paolo Mantovani, Abhinav Parihar, Heyu Yin, Denise Oswalt, Alexander Misdorp, Ilke Uguz, Tori Shinn, Gabrielle J. Rodriguez, Cate Nealley, Tjitse van der Molen, Sophia Sanborn, Ian Gonzales, Michael Roukes, Jeffrey Knecht, Kenneth S. Kosik, Daniel Yoshor, Peter Canoll, Eleonora Spinazzi, Luca P. Carloni, Bijan Pesaran, Saumil Patel, Joshua Jacobs, Brett Youngerman, R. James Cotton, Andreas Tolias, Kenneth L. Shepard
Electrocorticography uses non-penetrating electrodes embedded in flexible substrates to record electrical activity from the surface of the brain. To use the technology to develop minimally invasive, high-bandwidth brain–computer interfaces, it will be necessary to improve the number of recording channels and the scalability of devices, which could be achieved by merging electrodes and electronics onto a single substrate. Here we report a 50-μm-thick, mechanically flexible micro-electrocorticography brain–computer interface that integrates a 256 × 256 array of electrodes, signal processing, data telemetry and wireless powering on a single complementary metal–oxide–semiconductor substrate. The device contains 65,536 recording electrodes, from which we can simultaneously record a selectable subset of up to 1,024 channels at a given time. Our chip is wirelessly powered, and when implanted below the dura, it can communicate bidirectionally with an external relay station outside the body. We show that the device can provide chronic, reliable recordings for up to two weeks in pigs and up to two months in behaving non-human primates from the somatosensory, motor and visual cortices, decoding brain signals at high spatiotemporal resolution. A flexible micro-electrocorticography brain–computer interface that integrates a 256 × 256 array of electrodes, signal processing, data telemetry and wireless powering on a single complementary metal–oxide–semiconductor substrate can provide stable, chronic in vivo recordings.
{"title":"A wireless subdural-contained brain–computer interface with 65,536 electrodes and 1,024 channels","authors":"Taesung Jung, Nanyu Zeng, Jason D. Fabbri, Guy Eichler, Zhe Li, Erfan Zabeh, Anup Das, Konstantin Willeke, Katie E. Wingel, Agrita Dubey, Rizwan Huq, Mohit Sharma, Yaoxing Hu, Girish Ramakrishnan, Kevin Tien, Paolo Mantovani, Abhinav Parihar, Heyu Yin, Denise Oswalt, Alexander Misdorp, Ilke Uguz, Tori Shinn, Gabrielle J. Rodriguez, Cate Nealley, Tjitse van der Molen, Sophia Sanborn, Ian Gonzales, Michael Roukes, Jeffrey Knecht, Kenneth S. Kosik, Daniel Yoshor, Peter Canoll, Eleonora Spinazzi, Luca P. Carloni, Bijan Pesaran, Saumil Patel, Joshua Jacobs, Brett Youngerman, R. James Cotton, Andreas Tolias, Kenneth L. Shepard","doi":"10.1038/s41928-025-01509-9","DOIUrl":"10.1038/s41928-025-01509-9","url":null,"abstract":"Electrocorticography uses non-penetrating electrodes embedded in flexible substrates to record electrical activity from the surface of the brain. To use the technology to develop minimally invasive, high-bandwidth brain–computer interfaces, it will be necessary to improve the number of recording channels and the scalability of devices, which could be achieved by merging electrodes and electronics onto a single substrate. Here we report a 50-μm-thick, mechanically flexible micro-electrocorticography brain–computer interface that integrates a 256 × 256 array of electrodes, signal processing, data telemetry and wireless powering on a single complementary metal–oxide–semiconductor substrate. The device contains 65,536 recording electrodes, from which we can simultaneously record a selectable subset of up to 1,024 channels at a given time. Our chip is wirelessly powered, and when implanted below the dura, it can communicate bidirectionally with an external relay station outside the body. We show that the device can provide chronic, reliable recordings for up to two weeks in pigs and up to two months in behaving non-human primates from the somatosensory, motor and visual cortices, decoding brain signals at high spatiotemporal resolution. A flexible micro-electrocorticography brain–computer interface that integrates a 256 × 256 array of electrodes, signal processing, data telemetry and wireless powering on a single complementary metal–oxide–semiconductor substrate can provide stable, chronic in vivo recordings.","PeriodicalId":19064,"journal":{"name":"Nature Electronics","volume":"8 12","pages":"1272-1288"},"PeriodicalIF":40.9,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145711518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-05DOI: 10.1038/s41928-025-01522-y
Peigen Zhang, He Tian
Two-dimensional field-effect transistors with damascene-type top contacts can be created using a selective etch process, providing a potential route to integrating two-dimensional transistors into back-end-of-line processes.
{"title":"Steps to integrating 2D transistors into the back-end of line","authors":"Peigen Zhang, He Tian","doi":"10.1038/s41928-025-01522-y","DOIUrl":"10.1038/s41928-025-01522-y","url":null,"abstract":"Two-dimensional field-effect transistors with damascene-type top contacts can be created using a selective etch process, providing a potential route to integrating two-dimensional transistors into back-end-of-line processes.","PeriodicalId":19064,"journal":{"name":"Nature Electronics","volume":"8 12","pages":"1130-1131"},"PeriodicalIF":40.9,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-05DOI: 10.1038/s41928-025-01521-z
Taeyoung Song, Asif Islam Khan
A three-dimensional dynamic random-access memory (DRAM) architecture that uses oxide-semiconductor channel transistors offers a route to high-density, low-power memory.
Pub Date : 2025-12-05DOI: 10.1038/s41928-025-01526-8
Shaocong Wang, Yuchao Yang
By integrating arrays of amorphous silicon photodiodes and polycrystalline silicon thin-film transistor spike generators, a neuromorphic silicon retina can be created that perceives and processes light as spikes.
{"title":"A silicon retina that works with spikes","authors":"Shaocong Wang, Yuchao Yang","doi":"10.1038/s41928-025-01526-8","DOIUrl":"10.1038/s41928-025-01526-8","url":null,"abstract":"By integrating arrays of amorphous silicon photodiodes and polycrystalline silicon thin-film transistor spike generators, a neuromorphic silicon retina can be created that perceives and processes light as spikes.","PeriodicalId":19064,"journal":{"name":"Nature Electronics","volume":"8 12","pages":"1134-1135"},"PeriodicalIF":40.9,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1038/s41928-025-01541-9
Hansol Park, Cheong Beom Lee, Jongmin Lee, Seon-Jeong Lim, Bum Ho Jeong, Hakjun Kim, Seong Jae Lee, Hayoung Oh, Hyungju Ahn, Do Hwan Kim, Kyeounghak Kim, Hui Joon Park
Pub Date : 2025-12-02DOI: 10.1038/s41928-025-01511-1
Carlo Vittorio Cannistraci, Eunhye Baek
An artificial spiking neuron that integrates six key neural functions within a single device could be used to build scalable neuromorphic networks.
在单个设备中集成了六个关键神经功能的人工尖峰神经元可用于构建可扩展的神经形态网络。
{"title":"Artificial neurons beyond spikes","authors":"Carlo Vittorio Cannistraci, Eunhye Baek","doi":"10.1038/s41928-025-01511-1","DOIUrl":"10.1038/s41928-025-01511-1","url":null,"abstract":"An artificial spiking neuron that integrates six key neural functions within a single device could be used to build scalable neuromorphic networks.","PeriodicalId":19064,"journal":{"name":"Nature Electronics","volume":"8 12","pages":"1140-1141"},"PeriodicalIF":40.9,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145664829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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