Pub Date : 2024-03-30DOI: 10.30574/wjbphs.2024.17.3.0105
A Zaizi, I Zizi, J Boukhris, D Benchebba, B Chafry, M Boussouga
Pycnodysostosis is a rare genetic disorder characterized by dense but brittle bones, short stature, and dental anomalies. This review summarizes the clinical presentation, genetic basis, diagnostic methods, and management strategies for pycnodysostosis. Early recognition and multidisciplinary care are crucial for optimizing outcomes and improving the quality of life for affected individuals. Further research into the pathophysiology of pycnodysostosis may lead to novel therapeutic approaches. We report a case of pycnodysostosis in a 23-year-old male sustaining a low energy right femoral shaft fracture.
{"title":"Pycnodysostosis: A rare case report","authors":"A Zaizi, I Zizi, J Boukhris, D Benchebba, B Chafry, M Boussouga","doi":"10.30574/wjbphs.2024.17.3.0105","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.3.0105","url":null,"abstract":"Pycnodysostosis is a rare genetic disorder characterized by dense but brittle bones, short stature, and dental anomalies. This review summarizes the clinical presentation, genetic basis, diagnostic methods, and management strategies for pycnodysostosis. Early recognition and multidisciplinary care are crucial for optimizing outcomes and improving the quality of life for affected individuals. Further research into the pathophysiology of pycnodysostosis may lead to novel therapeutic approaches. We report a case of pycnodysostosis in a 23-year-old male sustaining a low energy right femoral shaft fracture.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"7 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140361497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.30574/wjbphs.2024.17.3.0130
Carolin shanthi. A, Geethanjali Santhanam
Gender is a term that is used when referring to social, cultural, and psychological characteristics that affect and pertain to stereotypes, norms, traits, and roles of men and women “Gender diversity exists in every culture and geographic context. Transgender people are people whose gender identity is different from the gender they were thought to be at birth. "Trans" is often used as a shorthand for transgender. Transgender is an umbrella term for people whose gender identity or gender expression differs from the sex they were designed at birth. Aim and Objectives: To empower the transgender through intervention and food processing training. To collect the socio-demographic profile of the transgender population. To provide the entrepreneurship skill training on food processing. To provide the intervention on reproductive health. Materials and Methods: In this study, 100 transgender persons were selected by a random method. Variables including age, anthropometric factors, food habits were recorded for each case. The socio-demographic variables, anthropometric, clinical assessment, dietary pattern, and associated factors of transgender are evaluated using an appropriate questionnaire. Statistical comparison of means among different groups was performed using SPSS version 17.0. Before and after without control design was adopted for this study, such as design a single test group or area is selected and the dependent variable is measured before the introduction of the treatment. The treatment is then introduced and the dependent variable is measured again after the treatment has been introduced. And provide skill training on food processing-malted foods, Vegetable preservation, and processing, Bakery products development. Results: There were significant differences in anthropometric factors including height, weight, and BMI among the literacy levels (p<0.01). And acquired knowledge on food processing skills, trained to prepare various food products, empowered to start self-employment, Improvement of transgender population living standard.
{"title":"Empowerment of transgender people through intervention and food skill training","authors":"Carolin shanthi. A, Geethanjali Santhanam","doi":"10.30574/wjbphs.2024.17.3.0130","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.3.0130","url":null,"abstract":"Gender is a term that is used when referring to social, cultural, and psychological characteristics that affect and pertain to stereotypes, norms, traits, and roles of men and women “Gender diversity exists in every culture and geographic context. Transgender people are people whose gender identity is different from the gender they were thought to be at birth. \"Trans\" is often used as a shorthand for transgender. Transgender is an umbrella term for people whose gender identity or gender expression differs from the sex they were designed at birth. Aim and Objectives: To empower the transgender through intervention and food processing training. To collect the socio-demographic profile of the transgender population. To provide the entrepreneurship skill training on food processing. To provide the intervention on reproductive health. Materials and Methods: In this study, 100 transgender persons were selected by a random method. Variables including age, anthropometric factors, food habits were recorded for each case. The socio-demographic variables, anthropometric, clinical assessment, dietary pattern, and associated factors of transgender are evaluated using an appropriate questionnaire. Statistical comparison of means among different groups was performed using SPSS version 17.0. Before and after without control design was adopted for this study, such as design a single test group or area is selected and the dependent variable is measured before the introduction of the treatment. The treatment is then introduced and the dependent variable is measured again after the treatment has been introduced. And provide skill training on food processing-malted foods, Vegetable preservation, and processing, Bakery products development. Results: There were significant differences in anthropometric factors including height, weight, and BMI among the literacy levels (p<0.01). And acquired knowledge on food processing skills, trained to prepare various food products, empowered to start self-employment, Improvement of transgender population living standard.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.30574/wjbphs.2024.17.3.0466
Silas David Emmanuel, IM Bugaje, EM Okonkwo, S Umar, M Tanimu, MC adeyeye
Genetic(Pathogenic microbial free radical), lifestyle (social engagement) and environmental(free radical) are becoming unfathomable nowadays. Thus the rapid socio-economical development in recent decades, the proportion of elderly has rapidly, geometrically and arithmetically increased worldwide. In addition, many aging -related diseases have shown an upward trend, including nervous system disease, cardiovascular diseases, metabolic diseases, cancer diseases, covid-19 viral suppression infections, HIV/AID viral suppression infections etc., respectively. The burden of aging related disease has become an urgent global health wise challenge; thus, which would have been tackle with immediate alacrity for permanent solution. Although therapies involving these agents have shown promising potential with the efficacy of a good number of herbal products clearly established, many of them remain untested and their use are either poorly monitored or not even monitored at all. The consequence of this is an inadequate knowledge of their mode of action, potential adverse reactions, contraindications, and interactions with existing orthodox pharmaceuticals and functional foods to promote both safe and rational use of these agents. Since safety continues to be a major issue with the use of herbal remedies, it becomes imperative, therefore, that relevant regulatory authorities put in place appropriate measures to protect public. Selected ingredients of these dietary supplements include several vitamins, mineral, phytochemicals, complex of amino acid residues(proteins), probiotics, vitamins A, B, C, D and E assist in maintaining skin veracity. Zinc, Copper, and Selenium are the main minerals which are involve in sustenance of healthy skin. Phytochemical consisting of flavonoid, terpenoid, and alkaloids with antibacterial, antifungal, antioxidative property may benefit the texture and physiological parameters of skin delay.. In view of his review, it talks about results, discussions,toxicity-related issues and major safety concerns arising from the use of herbal medicinal products and also highlights some important challenges associated with effective monitoring of their bio-safety
{"title":"The complicated adverse effect relating to the used of direct herbal traditional extract(medicine) arbitrary in reciprocal to the use of modified herbal syrup containing antioxidants/nutraceuticals supplements (polyherbal drugs/syrup) as an active antiagi","authors":"Silas David Emmanuel, IM Bugaje, EM Okonkwo, S Umar, M Tanimu, MC adeyeye","doi":"10.30574/wjbphs.2024.17.3.0466","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.3.0466","url":null,"abstract":"Genetic(Pathogenic microbial free radical), lifestyle (social engagement) and environmental(free radical) are becoming unfathomable nowadays. Thus the rapid socio-economical development in recent decades, the proportion of elderly has rapidly, geometrically and arithmetically increased worldwide. In addition, many aging -related diseases have shown an upward trend, including nervous system disease, cardiovascular diseases, metabolic diseases, cancer diseases, covid-19 viral suppression infections, HIV/AID viral suppression infections etc., respectively. The burden of aging related disease has become an urgent global health wise challenge; thus, which would have been tackle with immediate alacrity for permanent solution. Although therapies involving these agents have shown promising potential with the efficacy of a good number of herbal products clearly established, many of them remain untested and their use are either poorly monitored or not even monitored at all. The consequence of this is an inadequate knowledge of their mode of action, potential adverse reactions, contraindications, and interactions with existing orthodox pharmaceuticals and functional foods to promote both safe and rational use of these agents. Since safety continues to be a major issue with the use of herbal remedies, it becomes imperative, therefore, that relevant regulatory authorities put in place appropriate measures to protect public. Selected ingredients of these dietary supplements include several vitamins, mineral, phytochemicals, complex of amino acid residues(proteins), probiotics, vitamins A, B, C, D and E assist in maintaining skin veracity. Zinc, Copper, and Selenium are the main minerals which are involve in sustenance of healthy skin. Phytochemical consisting of flavonoid, terpenoid, and alkaloids with antibacterial, antifungal, antioxidative property may benefit the texture and physiological parameters of skin delay.. In view of his review, it talks about results, discussions,toxicity-related issues and major safety concerns arising from the use of herbal medicinal products and also highlights some important challenges associated with effective monitoring of their bio-safety","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"17 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Superficial mycoses, especially those of nails, scalp and skin, are very common in various countries. The presence of specific terrain, as well as other factors, can affect the prevalence of these. In this sense, diabetic patients are more susceptible to infections especially fungal infections because of changes in the immune system and macro and microvascular changes. The objective of our study was to determine the epidemiological and mycological profile of superficial mycoses in diabetic patients at the Mohammed VI Hospital in Oujda (Morocco). Material and methods: This is a retrospective, observational and descriptive study spread over 34 months, from January 2021 to October 2023 at the Parasitology-Mycology laboratory of the Mohammed VI Hospital Center of Oujda. We collected demographic and mycological data for the included patients. In the laboratory, upon reception of the samples, a direct examination (DE) of the sample was obtained after clarification by KOH to better visualize the mycelial filaments or yeasts and culture on both media: Sabouraud with chloramphenicol and Sabouraud with chloramphenicol and cycloheximide is systematically carried out. Results: We collected 136 diabetic patients referred to our laboratory for suspicion of superficial mycosis. The latter was confirmed in 46 of the 136 diabetic patients (33.82%) referred to our laboratory, which corresponds to 50 lesions among the 166 sites taken, a prevalence of 30.12%. At the mycological examination, the DE allowed the confirmation of the diagnosis of mycoses in 64% (n=32) and showed most often mycelial filaments (n=21; 65.62%) especially at the level of the feet and yeasts were observed in particular at the level of the nails of the hands (n=11; 34.37%). While culture was positive in all cases without exception (100%; n=50), dermatophytes were the most frequently isolated fungi (n=30; 60%), followed by yeasts (n=20; 40%). By species, T. rubrum (n=30; 60%) was the only isolated dermatophyte species, followed by Candida albicans (n=17; 34%). Conclusion: In recent years, we have seen an increase in the prevalence of superficial mycoses in diabetic patients which is why we conducted this study. The results show on the one hand that the most isolated fungi in the superficial mycoses of these patients are dominated by dermatophytes, as T. rubrum represents the most frequently encountered species. Furthermore, the high prevalence of the latter demonstrates the significance of implementing important prevention measures.
{"title":"Epidemiological and mycological profile of superficial mycoses in diabetic patient","authors":"Fatiha Bousnina, Oumaima Nassiri, Oumaima kharkhach, Asmae Rhoubi, Samira Laghzaoui, A. Hami","doi":"10.30574/wjbphs.2024.17.3.0075","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.3.0075","url":null,"abstract":"Introduction: Superficial mycoses, especially those of nails, scalp and skin, are very common in various countries. The presence of specific terrain, as well as other factors, can affect the prevalence of these. In this sense, diabetic patients are more susceptible to infections especially fungal infections because of changes in the immune system and macro and microvascular changes. The objective of our study was to determine the epidemiological and mycological profile of superficial mycoses in diabetic patients at the Mohammed VI Hospital in Oujda (Morocco). Material and methods: This is a retrospective, observational and descriptive study spread over 34 months, from January 2021 to October 2023 at the Parasitology-Mycology laboratory of the Mohammed VI Hospital Center of Oujda. We collected demographic and mycological data for the included patients. In the laboratory, upon reception of the samples, a direct examination (DE) of the sample was obtained after clarification by KOH to better visualize the mycelial filaments or yeasts and culture on both media: Sabouraud with chloramphenicol and Sabouraud with chloramphenicol and cycloheximide is systematically carried out. Results: We collected 136 diabetic patients referred to our laboratory for suspicion of superficial mycosis. The latter was confirmed in 46 of the 136 diabetic patients (33.82%) referred to our laboratory, which corresponds to 50 lesions among the 166 sites taken, a prevalence of 30.12%. At the mycological examination, the DE allowed the confirmation of the diagnosis of mycoses in 64% (n=32) and showed most often mycelial filaments (n=21; 65.62%) especially at the level of the feet and yeasts were observed in particular at the level of the nails of the hands (n=11; 34.37%). While culture was positive in all cases without exception (100%; n=50), dermatophytes were the most frequently isolated fungi (n=30; 60%), followed by yeasts (n=20; 40%). By species, T. rubrum (n=30; 60%) was the only isolated dermatophyte species, followed by Candida albicans (n=17; 34%). Conclusion: In recent years, we have seen an increase in the prevalence of superficial mycoses in diabetic patients which is why we conducted this study. The results show on the one hand that the most isolated fungi in the superficial mycoses of these patients are dominated by dermatophytes, as T. rubrum represents the most frequently encountered species. Furthermore, the high prevalence of the latter demonstrates the significance of implementing important prevention measures.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"42 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140364202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zoonotic diseases pose significant public health threats worldwide, highlighting the need for effective surveillance strategies. The One Health approach, which recognizes the interconnection between human, animal, and environmental health, has gained traction as a comprehensive framework for addressing zoonotic disease surveillance. This review explores integrative strategies for zoonotic disease surveillance in the United States, focusing on the implementation of One Health principles. The review examines the collaborative efforts between human and animal health sectors, environmental agencies, and other relevant stakeholders in implementing One Health surveillance strategies. It highlights the importance of data sharing, communication, and coordination among these sectors to enhance early detection, rapid response, and effective control of zoonotic diseases. Key findings include the establishment of cross-sectoral surveillance systems, such as the National Notifiable Diseases Surveillance System (NNDSS) and the National Animal Health Monitoring System (NAHMS), which facilitate the collection and analysis of zoonotic disease data. These systems enable the identification of emerging zoonotic threats and the implementation of targeted interventions to mitigate risks. The review also discusses the role of technology, such as geographic information systems (GIS) and molecular epidemiology, in enhancing zoonotic disease surveillance. These tools enable the visualization of disease patterns and the tracking of disease transmission pathways, aiding in the development of effective control strategies. Challenges in implementing One Health surveillance strategies include limited resources, fragmented data systems, and regulatory barriers. Addressing these challenges requires increased investment in infrastructure, capacity building, and policy development to support integrated surveillance approaches. Overall, this review highlights the importance of One Health implementation in zoonotic disease surveillance and underscores the need for continued collaboration and innovation to enhance the effectiveness of surveillance efforts in the United States.
{"title":"Integrative strategies for zoonotic disease surveillance: A review of one health implementation in the United States","authors":"Olumuyiwa Tolulope Ojeyinka, Toritsemogba Tosanbami Omaghomi","doi":"10.30574/wjbphs.2024.17.3.0124","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.3.0124","url":null,"abstract":"Zoonotic diseases pose significant public health threats worldwide, highlighting the need for effective surveillance strategies. The One Health approach, which recognizes the interconnection between human, animal, and environmental health, has gained traction as a comprehensive framework for addressing zoonotic disease surveillance. This review explores integrative strategies for zoonotic disease surveillance in the United States, focusing on the implementation of One Health principles. The review examines the collaborative efforts between human and animal health sectors, environmental agencies, and other relevant stakeholders in implementing One Health surveillance strategies. It highlights the importance of data sharing, communication, and coordination among these sectors to enhance early detection, rapid response, and effective control of zoonotic diseases. Key findings include the establishment of cross-sectoral surveillance systems, such as the National Notifiable Diseases Surveillance System (NNDSS) and the National Animal Health Monitoring System (NAHMS), which facilitate the collection and analysis of zoonotic disease data. These systems enable the identification of emerging zoonotic threats and the implementation of targeted interventions to mitigate risks. The review also discusses the role of technology, such as geographic information systems (GIS) and molecular epidemiology, in enhancing zoonotic disease surveillance. These tools enable the visualization of disease patterns and the tracking of disease transmission pathways, aiding in the development of effective control strategies. Challenges in implementing One Health surveillance strategies include limited resources, fragmented data systems, and regulatory barriers. Addressing these challenges requires increased investment in infrastructure, capacity building, and policy development to support integrated surveillance approaches. Overall, this review highlights the importance of One Health implementation in zoonotic disease surveillance and underscores the need for continued collaboration and innovation to enhance the effectiveness of surveillance efforts in the United States.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"13 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140364540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.30574/wjbphs.2024.17.2.0046
Israel Osejie Okoduwa, Bankole Ibrahim Ashiwaju, Jane Osareme Ogugua, Jeremiah Olawumi Arowoogun, Kehinde Feranmi Awonuga, Evangel Chinyere Anyanwu
This review provides a comprehensive analysis of the progress made in cancer research within the United States. Over the past few decades, significant strides have been taken to understand the complexities of cancer, leading to breakthroughs in diagnostics, treatment modalities, and overall patient care. The review explores key themes, including advancements in genomic medicine, immunotherapy, and personalized treatment approaches. Advancements in genomic medicine have emerged as a cornerstone of cancer research, allowing for a deeper understanding of the genetic basis of various cancers. The integration of precision medicine techniques has facilitated the identification of specific genetic mutations, paving the way for targeted therapies tailored to individual patients. Genomic profiling has not only enhanced diagnostic accuracy but has also provided valuable insights into cancer heterogeneity, guiding researchers toward more effective and personalized treatment strategies. Immunotherapy has revolutionized cancer treatment by harnessing the body's immune system to target and eliminate cancer cells. The review delves into the remarkable progress in developing immune checkpoint inhibitors, adoptive cell therapies, and cancer vaccines. These innovations have shown unprecedented success in treating previously challenging malignancies, offering new hope for patients with advanced-stage cancers. The concept of personalized medicine is further explored, emphasizing the shift from a one-size-fits-all approach to tailoring treatments based on individual patient characteristics. The advent of liquid biopsies and advanced imaging techniques has enabled real-time monitoring of treatment responses, facilitating timely adjustments and improving overall patient outcomes. Despite these advancements, the review acknowledges persistent challenges, such as the need for enhanced collaboration between research institutions, the imperative for increased funding, and the importance of addressing healthcare disparities in cancer outcomes. The ongoing commitment to interdisciplinary research, translational initiatives, and a patient-centered approach is emphasized as essential for overcoming these challenges and further propelling the field of cancer research in the USA. In conclusion, this review paints a comprehensive picture of the remarkable progress in cancer research within the United States. The integration of genomic insights, immunotherapeutic breakthroughs, and personalized treatment approaches underscores a promising future for cancer patients, while acknowledging the necessity of continued efforts to address existing challenges and propel the field toward even greater advancements.
{"title":"Reviewing the progress of cancer research in the USA","authors":"Israel Osejie Okoduwa, Bankole Ibrahim Ashiwaju, Jane Osareme Ogugua, Jeremiah Olawumi Arowoogun, Kehinde Feranmi Awonuga, Evangel Chinyere Anyanwu","doi":"10.30574/wjbphs.2024.17.2.0046","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0046","url":null,"abstract":"This review provides a comprehensive analysis of the progress made in cancer research within the United States. Over the past few decades, significant strides have been taken to understand the complexities of cancer, leading to breakthroughs in diagnostics, treatment modalities, and overall patient care. The review explores key themes, including advancements in genomic medicine, immunotherapy, and personalized treatment approaches. Advancements in genomic medicine have emerged as a cornerstone of cancer research, allowing for a deeper understanding of the genetic basis of various cancers. The integration of precision medicine techniques has facilitated the identification of specific genetic mutations, paving the way for targeted therapies tailored to individual patients. Genomic profiling has not only enhanced diagnostic accuracy but has also provided valuable insights into cancer heterogeneity, guiding researchers toward more effective and personalized treatment strategies. Immunotherapy has revolutionized cancer treatment by harnessing the body's immune system to target and eliminate cancer cells. The review delves into the remarkable progress in developing immune checkpoint inhibitors, adoptive cell therapies, and cancer vaccines. These innovations have shown unprecedented success in treating previously challenging malignancies, offering new hope for patients with advanced-stage cancers. The concept of personalized medicine is further explored, emphasizing the shift from a one-size-fits-all approach to tailoring treatments based on individual patient characteristics. The advent of liquid biopsies and advanced imaging techniques has enabled real-time monitoring of treatment responses, facilitating timely adjustments and improving overall patient outcomes. Despite these advancements, the review acknowledges persistent challenges, such as the need for enhanced collaboration between research institutions, the imperative for increased funding, and the importance of addressing healthcare disparities in cancer outcomes. The ongoing commitment to interdisciplinary research, translational initiatives, and a patient-centered approach is emphasized as essential for overcoming these challenges and further propelling the field of cancer research in the USA. In conclusion, this review paints a comprehensive picture of the remarkable progress in cancer research within the United States. The integration of genomic insights, immunotherapeutic breakthroughs, and personalized treatment approaches underscores a promising future for cancer patients, while acknowledging the necessity of continued efforts to address existing challenges and propel the field toward even greater advancements.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"10 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.30574/wjbphs.2024.17.2.0042
Wayan Wariata, Sulaiman N Depamede, Made Sriasih, Anwar Rosyidi, Ryan Aryadin Putra
This study aims to analyze whether antibodies produced through multiple vaccinations of a synthetic Binder of Sperm Protein-1 (BSP-1) epitope to local rabbits, can react against BSP-1 found in the ruminant sperm. BSP-1 is one of the biomarkers suggested to authenticate sire fertility. The method used was immunoblot assay against frozen semen of Bali cattle and local buffalo, also against the extracts of the caput-, and cauda- epididymis, as well as the testis of the buffalo. Analyses showed that the antibodies reacted to antigens found in the frozen semen of cattle and buffalo. The most notable result was that the antibody reacted specifically to buffalo frozen semen. No reactions occurred to the extracts of the caput-, and cauda-epididymis, as well as to the testis of the buffalo. Further research is needed to ascertain whether the antibody can be used to develop a sire fertility detection kit.
{"title":"Immunoblot analysis of antibodies obtained from rabbits immunized with a synthetic Binder of Sperm Protein-1 (BSP-1) epitope","authors":"Wayan Wariata, Sulaiman N Depamede, Made Sriasih, Anwar Rosyidi, Ryan Aryadin Putra","doi":"10.30574/wjbphs.2024.17.2.0042","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0042","url":null,"abstract":"This study aims to analyze whether antibodies produced through multiple vaccinations of a synthetic Binder of Sperm Protein-1 (BSP-1) epitope to local rabbits, can react against BSP-1 found in the ruminant sperm. BSP-1 is one of the biomarkers suggested to authenticate sire fertility. The method used was immunoblot assay against frozen semen of Bali cattle and local buffalo, also against the extracts of the caput-, and cauda- epididymis, as well as the testis of the buffalo. Analyses showed that the antibodies reacted to antigens found in the frozen semen of cattle and buffalo. The most notable result was that the antibody reacted specifically to buffalo frozen semen. No reactions occurred to the extracts of the caput-, and cauda-epididymis, as well as to the testis of the buffalo. Further research is needed to ascertain whether the antibody can be used to develop a sire fertility detection kit.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"33 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.30574/wjbphs.2024.17.2.0081
Nwakamma Ninduwezuor-Ehiobu, Alex Olanrewaju Adekanmbi, Emmanuel Chigozie Ani, Ayodeji Abatan, Uchenna Izuka, Alexander Obaigbena
Plastic production and recycling have become integral processes in modern society, but their environmental and health impacts have garnered significant attention in recent years. This review outlines key findings from a comprehensive assessment of these impacts, drawing from a range of scientific literature and empirical studies. The environmental footprint of plastic production encompasses various stages, from extraction of raw materials to manufacturing and distribution. These processes contribute to greenhouse gas emissions, energy consumption, and pollution of air, water, and soil. Additionally, plastic waste, particularly single-use items, poses a significant threat to ecosystems and wildlife, with marine environments being particularly vulnerable. While recycling is often promoted as a solution to mitigate the environmental impact of plastics, its effectiveness is limited by various factors. Challenges such as contamination, inadequate infrastructure, and low rates of collection and recycling hinder the potential benefits. Moreover, the recycling process itself can generate pollutants and emissions, albeit to a lesser extent than primary production. Beyond environmental concerns, the health implications of plastic use are increasingly recognized. Plastics contain additives such as phthalates and bisphenols, which have been linked to endocrine disruption, reproductive issues, and other health problems in humans and wildlife. Furthermore, the accumulation of microplastics in the environment raises concerns about potential bioaccumulation and transfer through the food chain, with implications for human health. Addressing the environmental and health impacts of plastic production and recycling requires a multifaceted approach, including reduction of plastic consumption, improvement of recycling infrastructure and technologies, development of alternative materials, and policy interventions to promote sustainable practices. This assessment highlights the complex interplay between plastic usage, environmental degradation, and public health, underscoring the need for concerted efforts to mitigate these challenges.
{"title":"Assessing the environmental and health impacts of plastic production and recycling","authors":"Nwakamma Ninduwezuor-Ehiobu, Alex Olanrewaju Adekanmbi, Emmanuel Chigozie Ani, Ayodeji Abatan, Uchenna Izuka, Alexander Obaigbena","doi":"10.30574/wjbphs.2024.17.2.0081","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0081","url":null,"abstract":"Plastic production and recycling have become integral processes in modern society, but their environmental and health impacts have garnered significant attention in recent years. This review outlines key findings from a comprehensive assessment of these impacts, drawing from a range of scientific literature and empirical studies. The environmental footprint of plastic production encompasses various stages, from extraction of raw materials to manufacturing and distribution. These processes contribute to greenhouse gas emissions, energy consumption, and pollution of air, water, and soil. Additionally, plastic waste, particularly single-use items, poses a significant threat to ecosystems and wildlife, with marine environments being particularly vulnerable. While recycling is often promoted as a solution to mitigate the environmental impact of plastics, its effectiveness is limited by various factors. Challenges such as contamination, inadequate infrastructure, and low rates of collection and recycling hinder the potential benefits. Moreover, the recycling process itself can generate pollutants and emissions, albeit to a lesser extent than primary production. Beyond environmental concerns, the health implications of plastic use are increasingly recognized. Plastics contain additives such as phthalates and bisphenols, which have been linked to endocrine disruption, reproductive issues, and other health problems in humans and wildlife. Furthermore, the accumulation of microplastics in the environment raises concerns about potential bioaccumulation and transfer through the food chain, with implications for human health. Addressing the environmental and health impacts of plastic production and recycling requires a multifaceted approach, including reduction of plastic consumption, improvement of recycling infrastructure and technologies, development of alternative materials, and policy interventions to promote sustainable practices. This assessment highlights the complex interplay between plastic usage, environmental degradation, and public health, underscoring the need for concerted efforts to mitigate these challenges.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"24 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.30574/wjbphs.2024.17.2.0044
Ravindra B. Malabadi, Simuzar S. Mammadova, Kiran P. Kolkar, Sadiya MR, Raju K. Chalannavar, Karen Viviana Castaño Coronado
Cannabis has been used for thousands of years for recreational, medicinal, or religious purposes and the therapeutic potential of medicinal Cannabis was demonstrated in various medical conditions. The legalization of Cannabis is an important source of economic growth as it contributes to the growing revenue tax, and the creation of new workplaces. The maturity of the Cannabis market varies across the globe mainly due to differing legal environments and public attitudes towards Cannabis. Some countries such as Canada and the United States have adopted fully regulated frameworks that allow the cultivation, consumption, and retail distribution of various Cannabis products. Uruguay became the first country in the world to legalize the production, distribution and consumption of cannabis in 2013. The Cannabis market in Canada and the USA is experiencing rapid growth due to the country's legalization of recreational use. Regulations can also differ regarding how cannabis is used. However, the use, cultivation, and marketing of Medical Cannabis sativa (drug or Marijuana type ) is banned and prohibited in India due to the presence of high levels of psychoactive principle THC (Narcotic drug). On the other hand, Industrial Cannabis sativa (seed or fiber type) Hemp was legalized in 2021 by The Food Safety and Standards Authority of India (FSSAI), Government of India, New Delhi. In Azerbaijan, Cannabis is not available for medical or recreational use. Recreational Cannabis and medical marijuana are illegal in Azerbaijan. Marijuana is illegal for medical and recreational purposes in China. There is still a huge prejudice in society about medical Cannabis due to its recreational use. However, this scenario is changing, and the social resistance is decreasing for the medicinal use of Cannabis. The Cannabis (Hemp) market in India is predicted to experience a substantial revenue growth, with projections indicating that it will reach ₹US$100.80m by 2024. The Cannabis market worldwide is projected to reach a revenue of US$60.79bn in 2024. The global legal marijuana market size is expected to reach USD 73.6 billion by 2027 and is anticipated to expand at a CAGR of 18.1% during the forecast period.
{"title":"Cannabis sativa: A therapeutic medicinal plant-global marketing updates","authors":"Ravindra B. Malabadi, Simuzar S. Mammadova, Kiran P. Kolkar, Sadiya MR, Raju K. Chalannavar, Karen Viviana Castaño Coronado","doi":"10.30574/wjbphs.2024.17.2.0044","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0044","url":null,"abstract":"Cannabis has been used for thousands of years for recreational, medicinal, or religious purposes and the therapeutic potential of medicinal Cannabis was demonstrated in various medical conditions. The legalization of Cannabis is an important source of economic growth as it contributes to the growing revenue tax, and the creation of new workplaces. The maturity of the Cannabis market varies across the globe mainly due to differing legal environments and public attitudes towards Cannabis. Some countries such as Canada and the United States have adopted fully regulated frameworks that allow the cultivation, consumption, and retail distribution of various Cannabis products. Uruguay became the first country in the world to legalize the production, distribution and consumption of cannabis in 2013. The Cannabis market in Canada and the USA is experiencing rapid growth due to the country's legalization of recreational use. Regulations can also differ regarding how cannabis is used. However, the use, cultivation, and marketing of Medical Cannabis sativa (drug or Marijuana type ) is banned and prohibited in India due to the presence of high levels of psychoactive principle THC (Narcotic drug). On the other hand, Industrial Cannabis sativa (seed or fiber type) Hemp was legalized in 2021 by The Food Safety and Standards Authority of India (FSSAI), Government of India, New Delhi. In Azerbaijan, Cannabis is not available for medical or recreational use. Recreational Cannabis and medical marijuana are illegal in Azerbaijan. Marijuana is illegal for medical and recreational purposes in China. There is still a huge prejudice in society about medical Cannabis due to its recreational use. However, this scenario is changing, and the social resistance is decreasing for the medicinal use of Cannabis. The Cannabis (Hemp) market in India is predicted to experience a substantial revenue growth, with projections indicating that it will reach ₹US$100.80m by 2024. The Cannabis market worldwide is projected to reach a revenue of US$60.79bn in 2024. The global legal marijuana market size is expected to reach USD 73.6 billion by 2027 and is anticipated to expand at a CAGR of 18.1% during the forecast period.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"44 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.30574/wjbphs.2024.17.2.0084
Varenya S Sarangamath, E. Gopinath, J. Adlin, Jino Nesalin, V. Chandy
The transdermal route serves as a crucial pathway for delivering localized or systemic medications. Recognizing the skin's significance as a vital organ, it is imperative to develop effective strategies for drug delivery through this route. Invasomes represent a novel vesicular system that has shown superior transdermal penetration compared to traditional liposomes. Comprising phospholipids, ethanol, and terpene, invasomes exhibit suitable transdermal penetration properties for soft vesicles. These nanovesicles enhance drug permeability into the epidermis while minimizing systemic absorption, thereby confining drug action within the skin subcaste. In comparison to liposomes and ethosomes, invasomes penetrate deeper into the skin. They offer various advantages, including enhancing medication efficacy, improving patient compliance, and enhancing comfort. The ability to access the skin subcaste enhances the effectiveness of invasomes, which exert their effects by fluidizing the bilayer structure of stratum corneum (SC) lipids and disrupting lipid and intracellular protein interactions. These recently discovered vesicles are tailored for use in topical and transdermal drug delivery due to their saturation effect and high deformability, distinguishing them from transferosomes.
{"title":"Invasomes: A vesicular carrier for transdermal delivery","authors":"Varenya S Sarangamath, E. Gopinath, J. Adlin, Jino Nesalin, V. Chandy","doi":"10.30574/wjbphs.2024.17.2.0084","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0084","url":null,"abstract":"The transdermal route serves as a crucial pathway for delivering localized or systemic medications. Recognizing the skin's significance as a vital organ, it is imperative to develop effective strategies for drug delivery through this route. Invasomes represent a novel vesicular system that has shown superior transdermal penetration compared to traditional liposomes. Comprising phospholipids, ethanol, and terpene, invasomes exhibit suitable transdermal penetration properties for soft vesicles. These nanovesicles enhance drug permeability into the epidermis while minimizing systemic absorption, thereby confining drug action within the skin subcaste. In comparison to liposomes and ethosomes, invasomes penetrate deeper into the skin. They offer various advantages, including enhancing medication efficacy, improving patient compliance, and enhancing comfort. The ability to access the skin subcaste enhances the effectiveness of invasomes, which exert their effects by fluidizing the bilayer structure of stratum corneum (SC) lipids and disrupting lipid and intracellular protein interactions. These recently discovered vesicles are tailored for use in topical and transdermal drug delivery due to their saturation effect and high deformability, distinguishing them from transferosomes.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"559 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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