A simple one, accurate and precise method for estimating tucatinib in tablet dosage form was developed on symmetry C18 column (150x4.6mm, 3.5µ) using buffer and acetonitrile 40:60 pumped through a column with 1ml/min flow rate 0.1 percent formic acid of the buffer used in this method. The run time was 6 min in assay method and 12 min in bio analytical method. Reference standard and sample solutions were prepared by dissolving firstly in acetonitrile and diluted with diluents (mobile phase). Cisplatin was used as internal standard in bio analytical technique. These assay and bio analytical methods establish good linearity results (R2-0.999) with an optimized wavelength of 220nm. The technique was validated in assay method with respect to specificity, linearity, accuracy, robustness, LOD, LOQ, method precision, intermediate precision, degradation and in bio analytical method the technique was validated regarding specificity, linearity, recovery, matrix factor, precision, accuracy, and stability. Keywords: Tucatinib, HPLC, Development, LC-MS/MS, Rat plasma.
{"title":"BIO ANALYTIC AND ANALYTIC METHOD QUANTITATIVE TO TUCATINIB ESTIMATION IN PURE AND PHARMACEUTICAL DOSAGE FORM","authors":"S. Mohan","doi":"10.37896/ymer21.08/65","DOIUrl":"https://doi.org/10.37896/ymer21.08/65","url":null,"abstract":"A simple one, accurate and precise method for estimating tucatinib in tablet dosage form was developed on symmetry C18 column (150x4.6mm, 3.5µ) using buffer and acetonitrile 40:60 pumped through a column with 1ml/min flow rate 0.1 percent formic acid of the buffer used in this method. The run time was 6 min in assay method and 12 min in bio analytical method. Reference standard and sample solutions were prepared by dissolving firstly in acetonitrile and diluted with diluents (mobile phase). Cisplatin was used as internal standard in bio analytical technique. These assay and bio analytical methods establish good linearity results (R2-0.999) with an optimized wavelength of 220nm. The technique was validated in assay method with respect to specificity, linearity, accuracy, robustness, LOD, LOQ, method precision, intermediate precision, degradation and in bio analytical method the technique was validated regarding specificity, linearity, recovery, matrix factor, precision, accuracy, and stability. Keywords: Tucatinib, HPLC, Development, LC-MS/MS, Rat plasma.","PeriodicalId":23848,"journal":{"name":"YMER Digital","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80072784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A sensitive HPLC method has been developed and validated for the determination of Triamcinolone Acetonide and 5-Fluorouracil in topical formulations. The developed method is found to be specific, reproducible and stability indicating. The Phenomenex C18, 250 × 4.6 mm, 5µm particle size column was used and mobile phase contains two solvents: Solvent A contains 10mM phosphate buffer pH 3.0 and solvent B was Acetonitrile. The detector linearity was established from concentrations ranging from 1 μg/ml to 10 μg/ml for both Triamcinolone Acetonide and 5-Fluorouracil with a correlation coefficient of 0.999. The limit of detection(LOD) and limit of quantification(LOQ) for Triamcinolone Acetonide was found to be 0.04 and 0.13 respectively and 5-Fluorouracil was found to be 0.01 and 0.03 respectively. The method was proved to be robust with respect to changes in flow rate, column temperature, mobile phase ratio and detector wavelength. Keywords: Triamcinolone Acetonide, 5-fluorouracil, Validation, HPLC method, topical formulations
{"title":"Development and Validation of HPLC Method for the estimation of Triamcinolone Acetonide and 5-Fluorouracil","authors":"Gulati Diksha","doi":"10.37896/ymer21.08/63","DOIUrl":"https://doi.org/10.37896/ymer21.08/63","url":null,"abstract":"A sensitive HPLC method has been developed and validated for the determination of Triamcinolone Acetonide and 5-Fluorouracil in topical formulations. The developed method is found to be specific, reproducible and stability indicating. The Phenomenex C18, 250 × 4.6 mm, 5µm particle size column was used and mobile phase contains two solvents: Solvent A contains 10mM phosphate buffer pH 3.0 and solvent B was Acetonitrile. The detector linearity was established from concentrations ranging from 1 μg/ml to 10 μg/ml for both Triamcinolone Acetonide and 5-Fluorouracil with a correlation coefficient of 0.999. The limit of detection(LOD) and limit of quantification(LOQ) for Triamcinolone Acetonide was found to be 0.04 and 0.13 respectively and 5-Fluorouracil was found to be 0.01 and 0.03 respectively. The method was proved to be robust with respect to changes in flow rate, column temperature, mobile phase ratio and detector wavelength. Keywords: Triamcinolone Acetonide, 5-fluorouracil, Validation, HPLC method, topical formulations","PeriodicalId":23848,"journal":{"name":"YMER Digital","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84928142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: - This study aims to show the significant relationship between Transformational Leadership and Authentic Leadership in higher educational institutes. Research Methodology: - This study follows a literature review approach. The study presents 70 research papers published in leading journals from 2011-to 2021. This Review provides an understanding of the direction for future researchers. Findings: - The finding of this study is that transformational Leadership and authentic leadership influence higher education. The study found that Transformational Leadership and Authentic Leadership significantly influence higher education. Transformational leaders are energetic passionate and inspire their followers to achieve the organization's goals. Authentic leaders promote authenticity among followers to enhance the better relationship with them. The higher educational institute needs Transformational Leadership and Authentic Leadership both for innovation. Conclusion & recommendations: - It can be concluded that transformational Leadership and Authentic Leadership have a significant relationship with the higher educational institute. The study recommends that higher educational institutes accept transformational Leadership and Authentic Leadership to improve performance and create innovation. Keywords: - Transformational Leadership, Authentic Leadership, appreciate, Higher education, Inspired, Employee engagement
{"title":"Transformational Leadership and Authentic Leadership Influenced on Higher Educational Institute","authors":"S. Kumari, Snigdha Dash","doi":"10.37896/ymer21.08/64","DOIUrl":"https://doi.org/10.37896/ymer21.08/64","url":null,"abstract":"Objectives: - This study aims to show the significant relationship between Transformational Leadership and Authentic Leadership in higher educational institutes. Research Methodology: - This study follows a literature review approach. The study presents 70 research papers published in leading journals from 2011-to 2021. This Review provides an understanding of the direction for future researchers. Findings: - The finding of this study is that transformational Leadership and authentic leadership influence higher education. The study found that Transformational Leadership and Authentic Leadership significantly influence higher education. Transformational leaders are energetic passionate and inspire their followers to achieve the organization's goals. Authentic leaders promote authenticity among followers to enhance the better relationship with them. The higher educational institute needs Transformational Leadership and Authentic Leadership both for innovation. Conclusion & recommendations: - It can be concluded that transformational Leadership and Authentic Leadership have a significant relationship with the higher educational institute. The study recommends that higher educational institutes accept transformational Leadership and Authentic Leadership to improve performance and create innovation. Keywords: - Transformational Leadership, Authentic Leadership, appreciate, Higher education, Inspired, Employee engagement","PeriodicalId":23848,"journal":{"name":"YMER Digital","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84737713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Most chronic illnesses as well as functional deficits happen to be exacerbated by aging. There happens to be an existing significant heterogeneity inside of the level that belongs to illness as well as functional impairment risk within an existing homogenous age group, highlighting the need that is going to belong to appropriate biomarkers to help inside of describing the complicated aging processes. The diversity that belongs to biological living environments, lifestyle activities, as well as medical treatments complicates the discovery that belongs to biomarkers even further. During the same time as an existing result, no one biomarker or gold standard instrument that is going to belong to monitoring effective or healthy aging has been identified. The current state that belongs to knowledge on top of possible biomarkers happens to be described inside of this brief overview, with an existing emphasis on top of their application to the primary physiological systems influenced by the aging process, such during the same time that physical capacity, nutritional status, body composition, as well as endocrine as well as immunological function. Keywords - Biomarkers, Aging, MARK-AGE consortium, biomarkers of different human organ systems, frailty syndrome biomarker, DNA methylation biomarker, Phenotypic biomarker, Genetic biomarker, Immunological biomarker, Cellular biomarker, Deep - Aging clocks
{"title":"Biomarkers associated with early detection of aging in human: a review","authors":"Aishi Bera, Preeti Roy","doi":"10.37896/ymer21.08/61","DOIUrl":"https://doi.org/10.37896/ymer21.08/61","url":null,"abstract":"Most chronic illnesses as well as functional deficits happen to be exacerbated by aging. There happens to be an existing significant heterogeneity inside of the level that belongs to illness as well as functional impairment risk within an existing homogenous age group, highlighting the need that is going to belong to appropriate biomarkers to help inside of describing the complicated aging processes. The diversity that belongs to biological living environments, lifestyle activities, as well as medical treatments complicates the discovery that belongs to biomarkers even further. During the same time as an existing result, no one biomarker or gold standard instrument that is going to belong to monitoring effective or healthy aging has been identified. The current state that belongs to knowledge on top of possible biomarkers happens to be described inside of this brief overview, with an existing emphasis on top of their application to the primary physiological systems influenced by the aging process, such during the same time that physical capacity, nutritional status, body composition, as well as endocrine as well as immunological function. Keywords - Biomarkers, Aging, MARK-AGE consortium, biomarkers of different human organ systems, frailty syndrome biomarker, DNA methylation biomarker, Phenotypic biomarker, Genetic biomarker, Immunological biomarker, Cellular biomarker, Deep - Aging clocks","PeriodicalId":23848,"journal":{"name":"YMER Digital","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86858111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A simple, specific, accurate and precise High Performance Thin Layer Chromatography (HPTLC) method was developed which can separate and quantitatively estimate formulation of Metformin Hydrochloride and Pioglitazone The chromatographic separation for Metformin Hydrochloride and Pioglitazone in HPTLC method separation was achieved with the mobile phase consisting of Toluene: Methanol: Triethylamine (6: 4: 0.1 % v/v/v/v). The detection of spot was carried out at 230 nm and the Rf values Metformin Hydrochloride and Pioglitazone were found to be 0.25±0.03 and 0.47±0.04.. Ths method was validated accordance with ICH guidelines. The recovery these combination were above 96%. The developed method are free from interference due to excipients present in tablets. These method are rapid and simple, do not require any sample preparation and is suitable for routine quality control analysis Keywords: HPTLC ,Method validation, Quantitative analysis
{"title":"DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE IN PHARMACEUTICAL DOSAGE FORM","authors":"G. Dharmamoorthy","doi":"10.37896/ymer21.08/52","DOIUrl":"https://doi.org/10.37896/ymer21.08/52","url":null,"abstract":"A simple, specific, accurate and precise High Performance Thin Layer Chromatography (HPTLC) method was developed which can separate and quantitatively estimate formulation of Metformin Hydrochloride and Pioglitazone The chromatographic separation for Metformin Hydrochloride and Pioglitazone in HPTLC method separation was achieved with the mobile phase consisting of Toluene: Methanol: Triethylamine (6: 4: 0.1 % v/v/v/v). The detection of spot was carried out at 230 nm and the Rf values Metformin Hydrochloride and Pioglitazone were found to be 0.25±0.03 and 0.47±0.04.. Ths method was validated accordance with ICH guidelines. The recovery these combination were above 96%. The developed method are free from interference due to excipients present in tablets. These method are rapid and simple, do not require any sample preparation and is suitable for routine quality control analysis Keywords: HPTLC ,Method validation, Quantitative analysis","PeriodicalId":23848,"journal":{"name":"YMER Digital","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81536286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The financial area in India has been various changes. The banks are the life savers of the economy and assume a synergist part in enacting and supporting financial development, particularly, in emerging nations and India is no exemption. Driving supporter for GDP in India is Banking Industry. The vast majority of the banks have started to adopt an enhance strategy towards banking, with the target of making more incentive for clients in the banks. Banking in India has previously gone through a gigantic change in the years since freedom. These days we have E Banking framework alongside money notes. India's financial framework can make another instrument alongside liquidity and wellbeing. The Indian financial area where presented appearance of the card, presentation of Electronic Clearing Service (ECS) in 1990's such as “EFT, RTGS, NEFT” versatile banking, web-based banking are the different developments in banking. This paper focuses an outline of advancements in financial area. Keywords: Innovate banking. Challenges of banking, New Technological changes, Indian banking sector
{"title":"AN OVERVIEW OF INNOVATIVE PRODUCTS AND TECHNIQUES IN BANKING INDUSTRIES","authors":"R. Vijayalakshmi, J. Srinivasan","doi":"10.37896/ymer21.08/56","DOIUrl":"https://doi.org/10.37896/ymer21.08/56","url":null,"abstract":"The financial area in India has been various changes. The banks are the life savers of the economy and assume a synergist part in enacting and supporting financial development, particularly, in emerging nations and India is no exemption. Driving supporter for GDP in India is Banking Industry. The vast majority of the banks have started to adopt an enhance strategy towards banking, with the target of making more incentive for clients in the banks. Banking in India has previously gone through a gigantic change in the years since freedom. These days we have E Banking framework alongside money notes. India's financial framework can make another instrument alongside liquidity and wellbeing. The Indian financial area where presented appearance of the card, presentation of Electronic Clearing Service (ECS) in 1990's such as “EFT, RTGS, NEFT” versatile banking, web-based banking are the different developments in banking. This paper focuses an outline of advancements in financial area. Keywords: Innovate banking. Challenges of banking, New Technological changes, Indian banking sector","PeriodicalId":23848,"journal":{"name":"YMER Digital","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84007059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetes mellitus (DM) is a long-term disease that can be caused by a lack of insulin production by the pancreas, or by the ineffectiveness of the insulin produced. For the study, the antidiabetic effects of methanolic and 50% v/v hydroalcoholic methanolic and extracts of the leaves of Inula cappa were used as oral doses at 100, 200, and 400 mg/kg and Metformine (50 mg/kg) were administered continuously for 21 days as a single morning dose. 18 hours of fasting was used to assess the drug's anti-diabetic effects in normoglycemic rats. On the 0th, 10th, and 21st days of the experiment, glucose oxidase method readings were collected using an autoanalyzer to assess fasting blood glucose levels. Anti-oxidant parameters were determined including, total phenolic content, total flavonoid concentration, DPPH free radical scavenging activity, Hydroxyl radical scavenging activity, Scavenging of Hydrogen Peroxide, Superoxide radical scavenging assay, Nitric oxide scavenging activity and Reducing power assay. The methanolic (ICME) and hydroalcoholic (ICHE) extracts of Inula cappa leaves (100, 200, and 400 mg/kg, p.o.) passes the Oral Glucose Tolerance Test. Both extracts had a greater impact in lowering blood glucose levels. Out of which ICHE at all doses showed significant effect (P<0.05-P<0.001) when compared with control. ICME in terms of glucose tolerance at all doses had significant effects. Keywords: Diabetes mellitus, insulin, metformine, scavenging, Inula cappa.
{"title":"ASSESSMENT OF INULA CAPPA LEAVES EXTRACTS FOR ANTIDIABETIC POTENTIAL IN EXPERIMENTAL ANIMALS","authors":"A. Verma","doi":"10.37896/ymer21.08/54","DOIUrl":"https://doi.org/10.37896/ymer21.08/54","url":null,"abstract":"Diabetes mellitus (DM) is a long-term disease that can be caused by a lack of insulin production by the pancreas, or by the ineffectiveness of the insulin produced. For the study, the antidiabetic effects of methanolic and 50% v/v hydroalcoholic methanolic and extracts of the leaves of Inula cappa were used as oral doses at 100, 200, and 400 mg/kg and Metformine (50 mg/kg) were administered continuously for 21 days as a single morning dose. 18 hours of fasting was used to assess the drug's anti-diabetic effects in normoglycemic rats. On the 0th, 10th, and 21st days of the experiment, glucose oxidase method readings were collected using an autoanalyzer to assess fasting blood glucose levels. Anti-oxidant parameters were determined including, total phenolic content, total flavonoid concentration, DPPH free radical scavenging activity, Hydroxyl radical scavenging activity, Scavenging of Hydrogen Peroxide, Superoxide radical scavenging assay, Nitric oxide scavenging activity and Reducing power assay. The methanolic (ICME) and hydroalcoholic (ICHE) extracts of Inula cappa leaves (100, 200, and 400 mg/kg, p.o.) passes the Oral Glucose Tolerance Test. Both extracts had a greater impact in lowering blood glucose levels. Out of which ICHE at all doses showed significant effect (P<0.05-P<0.001) when compared with control. ICME in terms of glucose tolerance at all doses had significant effects. Keywords: Diabetes mellitus, insulin, metformine, scavenging, Inula cappa.","PeriodicalId":23848,"journal":{"name":"YMER Digital","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78374614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Treatments for the current global COVID-19 pandemic are still being studied. There are many drugs like Antivirals and immunomodulators have had varying degrees of success in clinical trials. Traditional herbal treatments are widely used to treat a variety of ailments. for disease prevention and treatment, particularly in countries with limited resources. It is really worth noting that now in lower elevations, COVID-related mortality rates were lower. Countries in comparison to the western world other factors that contributed to the disparity nationality, temp, relative humidity, normal resistance, and nourishment are all factors to consider. Objective: The goal of this study was to find out popularity of traditional herbs were utilized in north India to protect against COVID. Method: From October to November 2021, a questionnaire-based study was done in Dehradun district at different place North India. The brief interview was conducted at the request of the participants. A pre-designed questionnaire was used to record responses (Annexure). The data was analyses using descriptive statistics. The interview drew a total of 500 participants. Mask was utilized by the majority of respondents 84%. The use of traditional herbs and spices was affirmed by 66% of the respondents. COVID positive was found in 4 % (n = 10) of the respondents' family members. Key world: COVID-19, Traditional herb, statistics, questionnaire, immunity
{"title":"POPULARITY OF AYURVEDIC MEDICINE AFTER COVID-19","authors":"Nidhi Gairola","doi":"10.37896/ymer21.08/47","DOIUrl":"https://doi.org/10.37896/ymer21.08/47","url":null,"abstract":"Treatments for the current global COVID-19 pandemic are still being studied. There are many drugs like Antivirals and immunomodulators have had varying degrees of success in clinical trials. Traditional herbal treatments are widely used to treat a variety of ailments. for disease prevention and treatment, particularly in countries with limited resources. It is really worth noting that now in lower elevations, COVID-related mortality rates were lower. Countries in comparison to the western world other factors that contributed to the disparity nationality, temp, relative humidity, normal resistance, and nourishment are all factors to consider. Objective: The goal of this study was to find out popularity of traditional herbs were utilized in north India to protect against COVID. Method: From October to November 2021, a questionnaire-based study was done in Dehradun district at different place North India. The brief interview was conducted at the request of the participants. A pre-designed questionnaire was used to record responses (Annexure). The data was analyses using descriptive statistics. The interview drew a total of 500 participants. Mask was utilized by the majority of respondents 84%. The use of traditional herbs and spices was affirmed by 66% of the respondents. COVID positive was found in 4 % (n = 10) of the respondents' family members. Key world: COVID-19, Traditional herb, statistics, questionnaire, immunity","PeriodicalId":23848,"journal":{"name":"YMER Digital","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73642917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psoriasis is a common inflammatory skin disease with an incompletely understood etiology. The disease is characterized by red, scaly and well-demarcated skin lesions. It is an immune – mediated chronic inflammatory skin disease affecting approximately 2-3% of worldwide population. Psoriasis has a negative impact on the patient’s health and quality of life and affects the quality of family members. Skin and joints affecting around 0.5-1% of children and 2-3% of adults. It can occur at any age, although the majority of cases develop before the age of 40 year and it is common in Children. Psoriasis is a chronic inflammatory disease, predominantly affecting the skin included in the group of immune mediated inflammatory disease and several systemic condition like metabolic syndrome, cardiovascular disease, diabetes, Arthritis, obesity, hypertension, Cancer are prevalent in psoriasis patients. This review offers inside into management of psoriasis and pharmaceutical approach for treatment for this disease. The review deals in details about topical drug delivery, phototherapy and biological against psoriasis. Review provides a detailed summary of the pathophysiology, epidemiology, of psoriasis. This review also summarizes different technology of nanotechnology methods of preparations.[26] Keywords: Psoriasis, skin disorder, inflammation, therapies for disease, Nanotechnology therapies.
{"title":"POLYMERIC NANOPARTICLES BASED TOPICAL DELIVERY SYSTEMS IN PSORIASIS","authors":"Shalini Vashisht","doi":"10.37896/ymer21.08/48","DOIUrl":"https://doi.org/10.37896/ymer21.08/48","url":null,"abstract":"Psoriasis is a common inflammatory skin disease with an incompletely understood etiology. The disease is characterized by red, scaly and well-demarcated skin lesions. It is an immune – mediated chronic inflammatory skin disease affecting approximately 2-3% of worldwide population. Psoriasis has a negative impact on the patient’s health and quality of life and affects the quality of family members. Skin and joints affecting around 0.5-1% of children and 2-3% of adults. It can occur at any age, although the majority of cases develop before the age of 40 year and it is common in Children. Psoriasis is a chronic inflammatory disease, predominantly affecting the skin included in the group of immune mediated inflammatory disease and several systemic condition like metabolic syndrome, cardiovascular disease, diabetes, Arthritis, obesity, hypertension, Cancer are prevalent in psoriasis patients. This review offers inside into management of psoriasis and pharmaceutical approach for treatment for this disease. The review deals in details about topical drug delivery, phototherapy and biological against psoriasis. Review provides a detailed summary of the pathophysiology, epidemiology, of psoriasis. This review also summarizes different technology of nanotechnology methods of preparations.[26] Keywords: Psoriasis, skin disorder, inflammation, therapies for disease, Nanotechnology therapies.","PeriodicalId":23848,"journal":{"name":"YMER Digital","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79419728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CSR of PSUs in Odisha is studied to find out the benefits of CSR to the local people. The environmental and philanthropic CSR are taken under the study by a mixed research method. Five selected PSUs are taken as the samples and found that the environmental CSR of PSUs’ is insignificant and not providing benefits to the local people. But the philanthropic CSR is highly impressive and benefiting to the local people. Henceforth, it is suggested to the executives of the PSUs that they should focus on practice of the environmental CSR to provide ultimate benefits to the local people and the planet. Finally, the executives should follow the NTPC’s CSR as the unique model for implementing the CSR and for providing benefits to the local beneficiaries. The CSR of NTPC, Kaniha is the role model CSR initiative for other PSUs in Odisha. Keywords: Selected PSUs, Environmental CSR, Philanthropic CSR, Benefits, Local beneficiaries
{"title":"Analytical Study of PSUs’ Environmental and Philanthropic CSR, Benefits to Local Beneficiaries in Odisha","authors":"N. Mohanty, S. Nath, P. K. Padhi","doi":"10.37896/ymer21.08/55","DOIUrl":"https://doi.org/10.37896/ymer21.08/55","url":null,"abstract":"CSR of PSUs in Odisha is studied to find out the benefits of CSR to the local people. The environmental and philanthropic CSR are taken under the study by a mixed research method. Five selected PSUs are taken as the samples and found that the environmental CSR of PSUs’ is insignificant and not providing benefits to the local people. But the philanthropic CSR is highly impressive and benefiting to the local people. Henceforth, it is suggested to the executives of the PSUs that they should focus on practice of the environmental CSR to provide ultimate benefits to the local people and the planet. Finally, the executives should follow the NTPC’s CSR as the unique model for implementing the CSR and for providing benefits to the local beneficiaries. The CSR of NTPC, Kaniha is the role model CSR initiative for other PSUs in Odisha. Keywords: Selected PSUs, Environmental CSR, Philanthropic CSR, Benefits, Local beneficiaries","PeriodicalId":23848,"journal":{"name":"YMER Digital","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79606745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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