Excess sodium (Na) intake is a major risk factor for hypertension, with taste perception and hedonic preference influencing consumption. This study examined demographic, body composition, and genetic influences on saltiness perception, pleasantness ratings, and Na intake among 211 young adults in Malaysia (median age 21 ± 3 years; 64.9 % females). Participants evaluated NaCl solutions (0.01, 0.1, 1.0 M) and spiced soups varying in NaCl, KCl, and MSG, answered a semi quantitative food frequency questionnaire of 22 common high-Na Malaysian foods, had anthropometrics/body compositions taken, and SCNN1B rs239345 and TRPV1 rs8065080 genotyped. Saltiness intensity ratings rose with concentration, while pleasantness followed an inverted U-shape, peaking for 0.1 M NaCl and low NaCl+low KCl + high MSG soup. Pleasantness did not differ between high NaCl soup and low NaCl+high KCl + low MSG soup (p = 0.107). Males rated higher pleasantness ratings for low NaCl solution and soups, lower perceived saltiness of low NaCl+high KCl + low MSG soup and higher total daily Na intake (median 1891.1 ± 1260.2 vs. 1404.4 ± 1396.7 mg/day) than females. Central adiposity was associated with lower perceived saltiness of control and low NaCl+low KCl + high MSG soups. SCNN1B and TRPV1 had limited genetic influences on sensory evaluations of salty stimuli, but were associated with Na consumption patterns - TRPV1 CC genotype/C allele carriers had higher daily Na intakes from selected Malaysian foods. These findings highlight demographic, physiological, and genetic drivers of Na consumption, suggesting that public health strategies incorporating taste modulation and genetic awareness may help reduce excess salt intake in young adults.
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