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The Effect of Murine Herpesvirus 68 (MHV-68) Related Growth Factor 68 (MHGF-68) on the Tumor Progression in Athymic Nude Mice 小鼠疱疹病毒68 (MHV-68)相关生长因子68 (MHGF-68)对胸腺裸鼠肿瘤进展的影响
Pub Date : 2019-01-15 DOI: 10.11648/J.AJBLS.20180606.13
M. Šupolíková, M. Labudova, E. Nováková, A. Staňová, V. Šišovský, F. Golais
In this study the effect of MHV-68 related growth factor 68 (MHGF-68) on initiation and progression of tumor growth using fractions in various stages of purification and treated with various chemical methods was demonstrated. The biological sample in the form of culture medium of BHK-21 cells infected with Murine herpesvirus 68 (MHV-68) was fractionated using conventional chemical procedures (dilution by deionized water and physiological solution pH 7.2, centrifugation and extraction with n-butanol and chloroform) and different chromatographic techniques. All obtained fractions were tested for biological activity. In the experiments were used 4 weeks old athymic nude mice, subcutaneously infected with the suspension of tumor Hepa 1c1c7 cells. Within 8 days post administration tumor proliferation was observed. Subsequently intravenously administered MHGF-68 fractions 1B1 and 1D2 with the antiproliferative effect were tested in vivo to see their inhibitory activity on the initiation or progression of tumor growth in mice. Tumors in experimental mice treated with MHGF-68 fractions exhibited decreased growth of tumors in comparison to control mice. These data show that tumor xenografts were suppressed after treatment with 1B1 and 1D2 fractions of MHGF-68. Taken together, the promising potential of MHGF-68 in modulating tumor growth could be used as a foundation for development of novel cancer treatment measures with antiproliferative effects.
在本研究中,MHV-68相关生长因子68 (MHGF-68)在不同纯化阶段和不同化学方法处理的馏分中对肿瘤生长的开始和进展的影响进行了论证。以感染鼠疱疹病毒68 (Murine herpesvirus 68, MHV-68)的BHK-21细胞为培养基,采用常规化学方法(去离子水和生理溶液pH 7.2稀释,正丁醇和氯仿离心提取)和不同的层析技术对生物样品进行分离。所有得到的组分都进行了生物活性测试。实验选用4周龄胸腺裸小鼠,皮下感染肿瘤Hepa 1c1c7细胞悬液。给药后8 d内观察肿瘤增殖。随后静脉注射具有抗增殖作用的MHGF-68组分1B1和1D2进行体内实验,观察其对小鼠肿瘤生长的开始或进展的抑制活性。与对照小鼠相比,用MHGF-68组分处理的实验小鼠肿瘤表现出肿瘤生长减少。这些数据表明,用MHGF-68的1B1和1D2部分治疗后,肿瘤异种移植物受到抑制。综上所述,MHGF-68在调节肿瘤生长方面的潜力可以作为开发具有抗增殖作用的新型癌症治疗措施的基础。
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引用次数: 1
Improving Corrosion Resistance of Co Using Silane Coupling Treatment in Neutral Solution 中性溶液中硅烷偶联处理提高Co的耐蚀性
Pub Date : 2019-01-15 DOI: 10.11648/j.ajpa.20180606.13
K. Mabuchi
Many products using a magnetic property, a mechanical property and chemical property of the thin metal film of the nm order are developing in the great many fields. The establishment of technology for corrosion prevention under nm level or the atom level is necessary to control corrosion without losing the characteristic of these products. In this study, surface treatments using BTSE, BTSPA, and BTSPS were evaluated from the viewpoint of improving the corrosion resistance of thin cobalt films. Corrosion behavior was evaluated corrosion current density using Tafel plots. Treated cobalt films were characterized by XPS and observed by SEM and AFM. A silane-coupling layer formed on the cobalt as a result of each of these treatments. However, the corrosion resistances offered by the different layers varied significantly. Immersion in BTSE with hydrogen peroxide for one hour did not yield an improvement, whereas immersion for 24 hours resulted in a large improvement. In contrast, immersion in BTSPA with hydrogen peroxide for 24 hours did not lead to a corrosion improvement, whereas immersion for one hour provided corrosion resistance. Immersion in BTSPS with hydrogen peroxide for either amount of time yielded no improvement, because of the poor coherency of the deposit on cobalt. These behaviors can be explained in terms of the hard and soft acid-base principle.
许多利用纳米级金属薄膜的磁性、力学和化学性能的产品正在许多领域得到开发。建立纳米级或原子级防腐蚀技术是控制腐蚀而不失去这些产品特性的必要条件。本研究从提高钴薄膜耐蚀性的角度对BTSE、BTSPA和BTSPS表面处理进行了评价。用Tafel图评价腐蚀电流密度的腐蚀行为。用XPS对处理后的钴膜进行了表征,并用SEM和AFM对处理后的钴膜进行了观察。这些处理的结果是在钴上形成硅烷偶联层。然而,不同层提供的耐腐蚀性差异很大。用双氧水浸泡BTSE一小时没有改善,而浸泡24小时则有很大改善。相比之下,在BTSPA中与双氧水浸泡24小时不会导致腐蚀改善,而浸泡1小时则具有耐腐蚀性。用双氧水浸泡在BTSPS中两种时间都没有改善,因为沉积在钴上的一致性很差。这些行为可以用软硬酸碱原理来解释。
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引用次数: 0
The First Law of Thermodynamics in Vector Form and Convective Heat Transfer 矢量形式的热力学第一定律与对流传热
Pub Date : 2018-12-25 DOI: 10.11648/J.AJPA.20180606.12
Davidzon Mikhail Yosifovich
Nowadays most of the practical calculations and theoretical findings in convective heat transfer amount to determining heat transfer coefficient (a coefficient of proportionality between surface density of the heat flux and temperature difference between the wall and the heated medium). An expression that includes heat transfer coefficient is called Newton’s law of cooling. The purpose of this study is to show that Newton’s law of cooling is not consistent with the first law of thermodynamics, and the study proves it using a new, vector form of the first law of thermodynamics, along with the more traditional scalar form. The study also offers a new analytically obtained expression for calculating surface density of the heat flux, and shows that it is not consistent with the Newton’s law of cooling. It also shows that Fourier’s thermal conduction law is a consequence of the first law of thermodynamics in vector form, and that Fourier-Richmann’s law of cooling and Newton’s law of cooling do not agree with the first law of thermodynamics. The results of this study can be used in engineering calculations for heat-using devices, as well as in a theoretical research. Additionally, the study suggests a new possible way to derive a nonlinear energy equation – by using vector form of the first law of thermodynamics. If previously obtained nonlinear Navier-Stokes equation is added to this nonlinear energy equation, a system of nonlinear equations could be obtained to correctly describe theory and practice of convective heat exchange, introducing completely new methods for calculating convective heat exchange (without using traditional heat transfer coefficients and laws of cooling).
目前,对流换热的大多数实际计算和理论发现都是关于换热系数(热流的表面密度与壁面和被加热介质之间的温差之间的比例系数)的确定。包含传热系数的表达式称为牛顿冷却定律。本研究的目的是证明牛顿冷却定律与热力学第一定律不一致,并使用热力学第一定律的一种新的矢量形式,以及更传统的标量形式来证明这一点。本文还提出了一种新的计算热流密度的解析表达式,并表明该表达式不符合牛顿冷却定律。还表明傅立叶热传导定律是矢量形式热力学第一定律的结果,而傅立叶-里奇曼冷却定律和牛顿冷却定律与热力学第一定律不一致。研究结果可用于热利用装置的工程计算,也可用于理论研究。此外,该研究提出了一种新的可能的方法来推导非线性能量方程-通过使用热力学第一定律的矢量形式。如果将之前得到的非线性Navier-Stokes方程加入到这个非线性能量方程中,就可以得到一个能够正确描述对流换热理论和实践的非线性方程组,从而引入全新的对流换热计算方法(不使用传统的换热系数和冷却定律)。
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引用次数: 2
Angular Correlations of Particle Momentum in the Hot Dense Medium 热致密介质中粒子动量的角关联
Pub Date : 2018-12-21 DOI: 10.11648/J.AJPA.20180606.11
Zirui Wang, Yuhuan Li
The early universe consists of element particles such as quarks and gluons after the big bang. Understanding their interactions is crucial for the physics, especially their interaction strength: do they behave like a gas or like water? A lot of experiments and theoretical calculations have been performed in labs, using different particles to study the properties of the early universe. Luckily, scientists can create this state of matter on earth by proton-proton collisions (or nucleus-nucleus collisions). As this matter produced in the particle collisions last only a very short of time ~ fm/c where c is the speed of light. How to probe this medium becomes difficult? This work suggests that people can study the momentum correlations between particles moving in the opposite direction in the hot medium. If the early universe is a STRONGLY coupled medium, then the medium will change both particles’ momentum. After they move out of the hot medium, their momentum angular is NOT pi anymore. In summary, the hot medium random interactions will change the momentum angular between two particles even their initial momentum is in the opposite direction. This work employs the Langevin equation to simulate their evolutions in the hot medium, and get good results.
大爆炸后的早期宇宙由夸克和胶子等元素粒子组成。了解它们的相互作用对物理学来说至关重要,尤其是它们的相互作用强度:它们的行为像气体还是像水?在实验室里进行了大量的实验和理论计算,使用不同的粒子来研究早期宇宙的性质。幸运的是,科学家们可以通过质子-质子碰撞(或核-核碰撞)在地球上创造出这种物质状态。由于这种物质在粒子碰撞中产生,只持续很短的时间~ fm/c,其中c为光速。如何探测这种介质就变得困难了?这项工作表明,人们可以研究在热介质中反向运动的粒子之间的动量相关性。如果早期宇宙是强耦合介质,那么介质将改变两个粒子的动量。当它们离开热介质后,它们的动量角不再是。综上所述,热介质随机相互作用会改变两个粒子之间的动量角,即使它们的初始动量方向相反。本文采用朗之万方程模拟了它们在热介质中的演化,得到了较好的结果。
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引用次数: 0
Advanced Physics of Thermoelectric Generators and Photovoltaic Cells 热电发电机和光伏电池高级物理
Pub Date : 2018-12-03 DOI: 10.11648/J.AJPA.20180605.14
S. Abdelhady
The measured efficiencies of modern photovoltaic solar cells that exceed the limit determined by Shockley and Queisser indicate a need for advanced physics to solve such conflict. Similarly, the duality confusion represents another conflict that acquires new physics. Such conflicts and confusions were recently solved by using an innovative definition of the nature of electric current as electromagnetic waves of electric potential. This definition was used to find also plausible physical explanation of the results of Tesla’s experiment of transmission of electric power in space and the success of Faraday in polarizing light by electric field in one of his experiments. Additionally, literature failed to find plausible physical explanation of estimating the electric potential of the output electric current from thermopiles and thermoelectric generators as the sum of electric potentials gained in crossing the junctions of these devices. It is shown in this paper that the introduced nature of electric current leads to advanced and plausible physical explanation of such results. It is shown also in this paper that the electric potential of the output electric current from multijunction photovoltaic cells can be estimated, similar to the thermopiles and TEG, as sum of electric potentials gained in crossing the junctions of these cells. Such similarity between the relations applied in estimating the gained potentials in all these multijunction-devices in addition to the relation found by Goldsmid and Sharp between the Seebeck coefficient and the energy bandgap prove that the Photovoltaic effect and the Seebeck effect corresponds simply to the same phenomenon. In other words; the gained potential in photovoltaic cells is generated by the thermal potential of the incident radiation and the difference of the Seebeck coefficients of the materials of its junctions. Such advanced physics may represent a gateway to understand other phenomena in the nature.
现代光伏太阳能电池的测量效率超过了肖克利和奎瑟确定的极限,这表明需要先进的物理学来解决这种冲突。同样,二元性的混淆代表了另一种获得新物理学的冲突。这种矛盾和困惑最近得到了解决,因为人们采用了一种创新的定义,将电流的性质定义为电势的电磁波。这个定义也被用来寻找对特斯拉在空间中传输电力的实验结果和法拉第在他的一个实验中通过电场偏振光的成功的合理的物理解释。此外,文献没有找到合理的物理解释来估计热电堆和热电发电机输出电流的电势,作为通过这些装置的连接处获得的电势之和。本文指出,引入电流的性质,可以对这些结果作出先进而合理的物理解释。本文还表明,与热电堆和TEG类似,多结光伏电池输出电流的电势可以估计为通过这些电池的结获得的电势之和。除了Goldsmid和Sharp发现的塞贝克系数与能带隙之间的关系之外,用于估计所有这些多结器件中获得的势的关系之间的这种相似性证明了光伏效应和塞贝克效应对应于相同的现象。换句话说;光伏电池中获得的电势是由入射辐射的热势和其结材料的塞贝克系数的差异产生的。这种先进的物理学可能是理解自然界其他现象的途径。
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引用次数: 2
Realistic Simulations of Non-Linear Acceleration of the Rocket in the Air 火箭在空中非线性加速度的逼真模拟
Pub Date : 2018-11-29 DOI: 10.11648/J.AJPA.20180605.13
H. Xiong
The motion of the object in the medium has always been a hot research topic, and it is closely connected with many applications in our life. The acceleration of the object with multiple forces becomes very complicated, especially when these forces depend on the motion of the object. The exact formula for the object motion is a differential-integral equation and is very difficult to be solved analytically. One example of this kind of motions is the rocket launch. With sufficient thrust, the rocket can obtain an acceleration large enough to escape from the gravity of the earth. With the increasing height, the gravity from the earth becomes smaller, which affects the net acceleration of the rocket. Meanwhile, the air resistance becomes more and more important when the velocity of the rocket increases. It even plays the main role in the middle stage of the launch. Also, as the air resistance depends on both the velocity of the rocket and the air density (there is no air resistance in vacuum), the air resistance will decrease when the air density becomes small enough at the large height. In this article, a model that includes all of the factors mentioned above is established, and how these forces change the velocity of the rocket is analyzed. Two scenarios, one with air resistance and one without, are described. The velocity of the rocket in each scenario is represented by graphs, which are compared. With justification, the Taylor series is used to solve the differential-integral equation, and it is found that the fuel thrust and the gravity become important in the rocket launch at the beginning stage. In the middle stage, the air resistance begins to have a significant effect and reduces the acceleration of the rocket. In the final stage, there is virtually no gravity or air resistance, and only the fuel thrust contributes to the acceleration of the rocket.
物体在介质中的运动一直是一个研究热点,它与我们生活中的许多应用密切相关。物体在多重力作用下的加速度变得非常复杂,特别是当这些力取决于物体的运动时。物体运动的精确公式是一个微分积分方程,很难解析求解。这种运动的一个例子是火箭发射。只要有足够的推力,火箭就能获得足够大的加速度以摆脱地球引力。随着高度的增加,来自地球的重力变小,这影响了火箭的净加速度。同时,随着火箭速度的增加,空气阻力也变得越来越重要。它甚至在发射的中间阶段起着主要作用。此外,由于空气阻力取决于火箭的速度和空气密度(在真空中没有空气阻力),当空气密度在大高度变得足够小时,空气阻力将减小。在本文中,建立了一个包括上述所有因素的模型,并分析了这些力如何改变火箭的速度。描述了两种情况,一种有空气阻力,一种没有空气阻力。火箭在每种情况下的速度用图表表示,并进行比较。在证明的基础上,采用泰勒级数求解了微分积分方程,发现燃料推力和重力在火箭发射起始阶段起着重要的作用。在中间阶段,空气阻力开始产生显著影响,降低了火箭的加速度。在最后阶段,几乎没有重力或空气阻力,只有燃料推力有助于火箭的加速。
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引用次数: 0
To the Theory of Low-Dimensional Hydrogen Molecules 到低维氢分子理论
Pub Date : 2018-11-09 DOI: 10.11648/J.AJPA.20180605.12
V. V. Skobelev
Using analytical and numerical methods, the possibility of existence of the elongated and flat hydrogen molecules H2 is first analyzed by analogy with the possibility of existence of low-dimensional single- and two-electron atoms previously proved theoretically (including us) and the impossibility of existence of the same multi-electron atom first pointed out in one of our previous works. In principle, conclusions of the present work can be verified experimentally, since low-dimensional, that is, one- and two-dimensional atoms were obtained experimentally long time ago. In our opinion, the material presented in the Appendix is of independent methodical interest because of its possible inclusion in traditional courses of quantum mechanics.
利用解析和数值方法,首先类比我们先前在理论上证明的低维单电子和双电子原子存在的可能性,以及我们先前的一篇作品中首次指出的相同多电子原子不存在的可能性,分析了细长扁平氢分子H2存在的可能性。原则上,本工作的结论可以通过实验得到验证,因为低维,即一维和二维原子很早以前就通过实验得到了。在我们看来,附录中提出的材料具有独立的方法论意义,因为它可能包含在传统的量子力学课程中。
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引用次数: 0
Investigation and the Improvement Strategy of the Inquiry Physics Experiment Teaching in Senior High School 高中探究式物理实验教学的调查与改进策略
Pub Date : 2018-10-25 DOI: 10.11648/J.AJPA.20180605.11
Cuixia Zhang, Huanxia Wang, Yu Liu, Ji-Quan Jiang
In accordance with the international trend, the new round of curriculum reform of basic education in China vigorously advocates inquiry teaching. Experiment plays an important role in physics. However, experiments have not been paid much attention in the past, so it is necessary to analyze how to carry out inquiry experiment teaching and investigate the current implementation status of inquiry-based experiment teaching. In this paper, literature research and questionnaire survey are conducted to investigate the students from the aspects of implementation conditions, implementation intention, implementation process and implementation effect of the inquiry physics experiment teaching. The results show that the present situation of physical inquiry experiment teaching is not optimistic. Although the overwhelming majority of students have positive intention to carry out the physical inquiry experiment, there are many problems in the implementation condition, implementation process and implementation effect of the physical inquiry experiment teaching. And it is in some degree trapped in the practical dilemma of formalism, which needs further improvement and perfection. Therefore, in order to promote the further optimization of exploratory experimental teaching, it is firstly suggested to provide multiparty support for the effective implementation of exploratory experiment teaching. Then, the operational examination is considered to be added in high-interest examinations. Finally, the physics teachers need to improve their professional quality.
顺应国际潮流,中国新一轮基础教育课程改革大力倡导探究性教学。实验在物理学中起着重要的作用。然而,实验在过去并没有受到足够的重视,因此有必要对如何开展探究性实验教学进行分析,并调查探究性实验教学的实施现状。本文采用文献研究法和问卷调查法,从探究性物理实验教学的实施条件、实施意图、实施过程和实施效果等方面对学生进行调查。结果表明,物理探究性实验教学的现状不容乐观。虽然绝大多数学生对开展物理探究性实验有积极的意愿,但在物理探究性实验教学的实施条件、实施过程、实施效果等方面存在诸多问题。它在一定程度上陷入了形式主义的实践困境,需要进一步改进和完善。因此,为了促进探究性实验教学的进一步优化,首先建议为探究性实验教学的有效实施提供多方支持。然后,考虑在高兴趣考试中增加操作考试。最后,物理教师需要提高自身的专业素质。
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引用次数: 5
A Method of Enhancing Fault Delineation Based on Reflection Strength AC Component Filtering 一种基于反射强度交流分量滤波的增强故障描述方法
Pub Date : 2018-10-12 DOI: 10.11648/J.AJPA.20180604.14
C. Zhigang, Tian Shuling, Sun Xing, W. Yuzhu, Han Yuchun, Ma Hui, C. Jie
Ant tracking technique is a widely used seismic interpretation method of identifying faults in the field of oil and gas exploration and development. However, due to its poor noise immunity, the fault identification effect of ant tracking could be easily affected by the quality of seismic data. Usually, two types of methods can be used to improve the effect of ant tracking, to improve the algorithm of ant tracking or to remove the noise of the seismic data. The first method is usually carried out by the research personnel, and it will take quite a long time before it can be integrated into the software, therefore, the de-noising method is more realistic for the interpreters. This paper puts forward a method of improving the effect of ant tracking by using AC component filtering of reflected intensity. In this method, the structural orientation filtering of the original seismic data is carried out first, and then a coherence cube is calculated based on multiple seismic trace dip scanning. Next, a filtering will be carried out on the coherence cube by using the AC component of the reflected intensity, and then the positive value after the filtering will be set to zero. Finally, the ant tracking will be processed based on the data volume. The improved ant tracking has a better fault identification effect with a higher fault identification rate, which is more favorable for the detailed interpretation of faults.
蚂蚁跟踪技术是油气勘探开发领域广泛应用的一种断层识别地震解释方法。然而,由于蚁群跟踪的抗噪能力较差,其故障识别效果容易受到地震数据质量的影响。通常可以采用两种方法来提高蚁群跟踪的效果,改进蚁群跟踪的算法或去除地震数据的噪声。第一种方法通常由研究人员进行,需要相当长的时间才能集成到软件中,因此,降噪方法对于口译员来说更现实。本文提出了一种利用反射强度的交流分量滤波来改善蚂蚁跟踪效果的方法。该方法首先对原始地震资料进行结构方位滤波,然后基于多次地震道倾角扫描计算相干立方。接下来,利用反射强度的交流分量对相干立方体进行滤波,滤波后的正值设为零。最后,根据数据量对蚂蚁跟踪进行处理。改进的蚁群跟踪具有较好的故障识别效果,故障识别率较高,更有利于故障的详细解释。
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引用次数: 0
In vivo Micro-Tomographic Visualization of Capillary Angio-Dynamics Around Upper Dermis Under Mechanical Stimulus Using Low Coherence Interferometer “Optical Coherence Doppler Velocigraphy” 低相干干涉仪“光学相干多普勒速度成像”在机械刺激下上真皮周围毛细血管动力学的体内显微层析成像
Pub Date : 2018-09-10 DOI: 10.11648/J.AJPA.20180604.13
D. Furukawa, S. Saeki, Takafumi Ito, Yoshiaki Nishino
The skin aging process, e.g. wrinkles and sagging, caused by not only aging but also ultraviolet irradiation, could be related to the depression of metabolic function. Therefore, an in vivo quantitative measurement of capillary blood flow velocity governing skin metabolism functionally, i.e. microcirculation, is crucial to clarify the skin aging and to create skincare products. The purpose of this study is to visualize the tomographic velocity of red blood cell in capillaries just below human epidermal skin using Optical Coherence Doppler Velocigraphy, namely OCDV. This was constructed on a low coherence interferometer, which could provide tomographic distribution of flow-modulated Doppler frequency by developing OCDV algorithm of Hilbert transform and adjacent autocorrelation. In order to validate OCDV system, this was in vivo applied to human forearm skin under respective mechanically stimulated conditions of control and avascularization. As a result, a cross-sectional imaging of blood flow velocity was found to display not only morphological OCT images but also networks of capillary vasculature inside dermal tissue. It was confirmed that blood flow velocity further decreased in upper dermis under avascularization than control condition. Additionally, OCDV could provide a velocity map of blood flow having sensitivity to mechanical stimulus, so has strong efficacy to diagnose “ Capillary Angio-Dynamics ” of skin tissue. In conclusions, OCDV system could be quite useful for a micro-tomographic imaging of blood flow velocity of capillaries inside skin.
皮肤的老化过程,如皱纹和松弛,除了老化,也与紫外线照射有关,可能与代谢功能的抑制有关。因此,体内定量测量控制皮肤代谢功能的毛细血管血流速度,即微循环,对于弄清皮肤老化和创造护肤品至关重要。本研究的目的是利用光学相干多普勒速度成像技术(OCDV)可视化人体表皮皮肤下方毛细血管中红细胞的层析速度。该系统建立在低相干干涉仪上,通过发展希尔伯特变换和相邻自相关的OCDV算法,可以提供流调制多普勒频率的层析分布。为了验证OCDV系统,我们分别在控制和无血管化的机械刺激条件下,将该系统在人体前臂皮肤上进行了体内应用。结果发现,血流速度的横断成像不仅可以显示形态学OCT图像,还可以显示真皮组织内的毛细血管网络。证实无血管化组真皮上部血流速度比对照组进一步降低。此外,OCDV可以提供对机械刺激敏感的血流速度图,因此对诊断皮肤组织的“毛细血管动力学”有很强的功效。综上所述,OCDV系统可用于皮肤内毛细血管血流速度的显微层析成像。
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引用次数: 2
期刊
American Journal of Physics and Applications
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