Saudi Dental Journal最新文献

Objective

Matrix metalloproteinase (MMP-1 and −9), Epidermal Growth Factor (EGF), and Transforming Growth factor (TGF)-β are expressed in the oral ulcer wound-healing process. The Adipose mesenchymal stem cell metabolites (AdMSCMs) may accelerate wound-healing. This study aimed to investigate the expression of MMP-1, MMP-9, EGF, and TGF-β in the oral mucosa ulcer rat model treated with topical AdMSCMs.

Materials and Methods

Oral ulcer models were created in twenty healthy male Wistar rats (Rattus novergicus) divided into AdMSCMs and control groups. The oral ulcer model was treated topically using AdMSCMs oral gel three times daily for 3 and 7 days. The expression of MMP-1, MMP-9, EGF, TGF-β was evaluated through histological examination using the immunohistochemistry method. Independent t-test was used to compare the mean of expression of MMP-1, MMP-9, EGF, TGF-β between control and treatment groups (AdMSCMs), and paired t-test was used to analyze the mean between day 3 and day 7 of each group.

Results

A lower expression of MMP-1, MMP-9 in AdMSCMs group and higher expression EGF and TGF-β in AdMSCMs group compared to the control group in day 3 and day 7. Independent t-test results showed a significant difference in the expression of MMP-1, MMP-9, EGF between the control and AdMSCMs group in day 3 and day 7. Only TGF-β expression mean difference between day 3 and day 7 showed a significant difference compared to the control groups (p < 0.05)

Conclusions

AdMSCMs oral gel may accelerate oral ulcer healing models by reducing the expression MMP-1, MMP-9, and increasing EGF and TGF-β expressions during the wound-healing process.

Purpose

Post removal may be necessary for many reasons and is inevitable after the re-application of a dental post. The present study investigated the bond strength between root dentin and a re-applied fibre-reinforced composite (FRC) post by a pull-out test.

Materials and methods

After root canal treatments of 30 extracted human maxillary canine teeth, post spaces were prepared (10 mm), and FRC posts (Hi-Rem Post; Overfibres, İmola, Italy) were luted with self-adhesive resin cement. The samples were than randomly divided into test and control groups (n = 15 in each). The FRC posts were removed in the test group, and new posts were cemented. The pull-out test (1 mm/minute speed) was used to measure the bond strength. Failure types were determined using a stereomicroscope. Mann-Whitney U, chi-square and Fisher-Freeman-Halton exact tests were used for statistical analysis.

Results

The bond strength values of the test (119.5 ± 36.86 N) and control (115.55 ± 55.44 N) groups did not differ significantly (p >.05). In terms of the percentage of failure types, there was a significant difference only in the test group between the mixed failure type and the other failure types (p <.05).

Conclusions

The re-application of FRC post did not seem to affect the bond strength. The distribution of failure types was similar between the control and test groups.

Objective

To assess the remineralizing efficiency of caesin phosphopepdide amorphous calcium phosphate (CPP-ACP) versus topical fluorides on early enamel lesions in vivo.

Data sources

PubMed, Web of Science, Scopus, EBSCO were searched based on the PICOS criteria up to December 2022 with English language restriction. All relevant studies were subjected to two separate reviews before being included at the title, abstract, and full text levels.

Study selection

41 studies were reviewed and 11 selected for inclusion in the final sample for the review. All were randomized clinical trials with the follow-up period of the studies ranging from 3 to 12 months. Out of the 11 studies, only two are with low risk of bias on assessment with Cochrane risk of bias assessment tool, while the other nine articles were with the moderate and high risk of bias.

Conclusions

Conflicting evidence exists on the clinical efficacy of CPP-ACP compared to the various fluoride forms tested, and no adverse effect associated with CPP-ACP use was discovered in comparison to fluorides that had certain detrimental health impacts. Although, the review results in favor of both fluorides and CPP-ACP with similar clinical efficiency, when ill effects are considered the CPP-ACP can be a choice of remineralizing early enamel lesions. However, before concrete suggestions can be given, high-quality, well-designed clinical research in this area are still necessary.

Clinical significance

A considerable remineralizing impact has been shown in both in vitro and in vivo experiments, making CPP-ACP/CPP-ACPF a more promising remineralizing agent than fluorides. Therefore, this can be applied clinically to early enamel carious lesion.

Dental general anesthesia (DGA) can be a preferred approach for treating children with special health needs (CSHCN). It has many benefits, most importantly, the support of the anesthesia team to control the medical status and treat the patient safely. The aim of this study was to evaluate the dental treatment provided to (CSHCN) under (DGA) in a tertiary-care hospital. Moreover, to compare the dental procedures between different medical conditions. This retrospective study involves a sample of 730 children aged between (1–16 years) with complex medical conditions treated under DGA between January 2009 until April 2022. The results show that 4.93 % of these patients had DGA twice. For those children who had DGA only once, the most frequent medical conditions were neuro-developmental disorders (31.8 %), pediatric oncology (17.4 %), and behavioral disorders (autism, ADHD, etc.) (15.1 %). The average age was 6.9 years; almost half were preschool children (4–6 years old, 48.41 %) followed by younger school children (7–9 years old, 28.82 %). The most common dental procedures done were extractions followed by restorative procedures. The use of fissure sealant was significantly higher in neuro-developmental and behavioral disabilities patients than other medical conditions.

Objective

This study aims to evaluate the sexual dimorphism of maxillary sinuses (MS) using cone-beam computed tomography (CBCT).

Method

A total of 80 CBCT scans were taken from Peruvian patients aged between 20 and 70 years-old. The dimensions (length, width, and height) of the MS were measured and evaluated. The data were analyzed using the Mann-Whitney U test with a significance level of p < 0.05.

Results

The left MS was wider than the right MS. Meanwhile, the right MS was longer than the left MS. In addition, the height of the right and left MS was significantly different in males and females, with p-value of 0.003 and 0.044 respectively. Bigger dimension of height of the MS was found in patients aged between 30 and 39 as well as patients aged between 40 and 49, whereas smaller dimension of height of the MS was found in patients aged between 60 and 70. Furthermore, the height of the right MS was significantly different in dentate and edentulous patients, with p-value of 0.033 and 0.043 respectively. The height of the right MS was predicted at 65 % in males and 70 % in females (p = 0.002).

Conclusion

The morphometry of the maxillary sinuses can be used for predicting sexual dimorphism.

Introduction

Endodontic treatment failures often stem from the presence of microbial pathogens, particularly Enterococcus faecalis and Candida albicans. This study systematically assesses the prevalence of E. faecalis and C. albicans in endodontic retreatment cases, aiming to explore their impact on treatment outcomes.

Methods

Employing a systematic sampling approach, 30 patients with a history of previous endodontic treatment were selected. Rigorous clinical and radiographic assessments were conducted, following standardized protocols for root canal sample collection. Microbiological analysis, utilizing selective culture media, was employed to identify and quantify E. faecalis and C. albicans. Statistical analyses, including chi-square and logistic regression tests, were performed.

Results

The study involved 30 patients undergoing endodontic retreatment, with comprehensive clinical and radiographic evaluations for cases with and without periradicular lesions. Microbiological analysis unveiled a significant prevalence of E. faecalis and C. albicans, establishing a robust association between these pathogens and retreatment failure. These findings underscore the critical need for targeted antimicrobial interventions to enhance the overall success rates of endodontic retreatment procedures.

Conclusion

This study highlights the substantial prevalence of E. faecalis and C. albicans in endodontic retreatment cases, emphasizing the importance of identifying and effectively managing these pathogens for successful treatment outcomes. The notable association between these microbial agents and retreatment failure underscores the imperative for tailored antimicrobial strategies to enhance the efficacy of endodontic retreatment procedures.

Introduction

Vesiculobullous disorders are a group of autoimmune diseases manifesting as chronic ulcers in the oral cavity. Ocular involvement may accompany oral ulcers and cause various problems for patients. This review summarizes the data regarding ocular involvement in patients with oral vesiculobullous.

Methods

Web of Science, Scopus, PubMed/MEDLINE, and Embase electronic databases were searched according to related keywords. Finally, 58 articles were included, all of which were case reports or series. Characteristics such as the age and sex of patients, location and type of oral lesion, type of ophthalmic injury, the interval between oral and ocular lesion, and treatment of oral and ocular disorders were summarized in tables.

Results

Eye involvement was 1.6 times more prevalent in women, and most patients were between 30 and 60 years old (67.4 %). Pemphigus vulgaris accounted for almost half of the cases (48.4 %), though lichen planus is more prevalent in the general population. The most frequently affected oral site was the buccal mucosa (17.5 %), and oral ulcers usually presented as erythema, erosion, or inflammation (22.7 %). Conjunctivitis was the most common type of eye involvement (18.4 %), and ophthalmic lesions regularly appeared 12–60 months after the development of oral lesions (30.1 %). Blindness was reported in only one case. Corticosteroids and immunosuppressives were the most frequent oral and ocular lesion therapies.

Conclusion

Considering the serious burdens of any ocular injury, monitoring the ocular health of patients with oral vesiculobullous diseases is highly recommended in high-risk cases, especially middle-aged women with oral pemphigus vulgaris.

Objective

To assess the impact of a novel touch-cure polymerization of dual-curing resin cement on the push-out bonding strength (PBS) of the conventional prefabricated glass fiber-reinforced composite (GFRC) and custom-made glass fiber (GF) posts at different root sections.

Methods

Forty single-root mandibular first premolars were treated endodontically and prepared for receiving the posts, the prepared roots were randomly divided into 4 groups. Group I: A prefabricated (GFRC) post was cemented by G-CEM ONE resin cement with adhesive-enhancing primer (AEP). Group II: A prefabricated (GFRC) post was cemented by G-CEM ONE without AEP. Group III: A customized (GF) post was cemented by G-CEM ONE with AEP. Group IV: A customized (GF) post was cemented by G-CEM ONE without AEP. (n = 10 for each group). The PBS was tested with a universal testing machine, and the values were analyzed with (ANOVA) and Tukey’s post hoc test at a P ≤ 0.05 significance level.

Results

Group III revealed the greatest PBS values, followed by Group IV, Group I, and finally, Group II showed the lowest PBS values. The coronal root slices showed the highest PBS in comparison with the middle and apical third.

Conclusion

The touch-cure polymerization improved the PBS of the prefabricated and customized fiber posts. Therefore, ‟touch and cure” cement may be considered a clinical alternative to conventional types of resin cement. The customized (GF) posts exhibited a higher PBS than the prefabricated (GFRC). The combination of customized posts and G-CEM ONE with AEP is recommended as a new strategic approach to improve interfacial adhesion.

Introduction

The association between the visceral swallowing pattern (VSP) and dentofacial abnormalities remains controversial. This cross-sectional study aimed to investigate the association between the VSP and various factors including type of birth, gender, tongue posture, lip incompetence, eruption of primary molars, habits and the presence of malocclusions in children with primary and early mixed dentition.

Material and method

A total of 219 children (102 boys and 117 girls) were evaluated using a combination of a questionnaire and a structured clinical examination by one pediatric specialist dentist. Kittel’s method of tongue posture evaluation and the Payne technique for assessment of swallowing pattern were included in the clinical examination of myofunctional status. After checking for normality, normal and non-normal distributed data were analyzed using two-sample t-test and Mann-Whitney U test, respectively. Analysis of categorical variables was done using a chi-square test, and Bonferroni correction was used as correction for multiple comparisons.

Results

A total of 56.2 % of the study population had a VSP. The chi-square test indicated a statistically significant higher presence of VSP in male gender. Statistically significant associations were seen between the VSP and lip incompetency, pathologic resting tongue position, habits, anterior open bite and increased overjet. On the other hand, no statistically significant associations were found between VSP and children’s age within the sample population, type of birth, uni- or bilateral crossbites, increased overbite, edge-to-edge anterior bite or completion of eruption of primary molars and/or permanent incisors.

Conclusions

The association between VSP and male gender, pathologic tongue posture, lip incompetency and habits and occlusal traits such as anterior open bite and increased anterior overjet is supported by the results of the present study.

Objective

To investigate the effectiveness of the microsurgical treatment in restoring full sensory recovery following trigeminal nerve injuries caused by iatrogenic oral and maxillofacial surgical interventions.

Methods

A detailed search was conducted on the Cochrane central register of controlled trials, Medline and Embase. Clinical studies with at least twelve months of follow up were included and assessment of risks of bias was made using the Robbin I assessment tool.

Results

Six studies were identified in the searches which include 227 patients. The lingual nerve was the most common injured nerve, followed by the inferior alveolar nerve. Third molar removal was the most frequent cause of nerve injury, followed by root canal treatment, pathology excision, coronectomy, orthognathic surgery, dental implants and then local anaesthetic injections. Overall, surgical interventions for nerve injuries showed neurosensory improvement postoperatively in the majority of patients.

Conclusion

Direct neurorrhaphy is still the gold-standard technique when the tension at the surgical site is minimal. Promising results have been noted on conduit applications following traditional repair or grafting. Further research is needed on the efficacy of allografting and conduit applications in nerve repair.