首页 > 最新文献

npj Flexible Electronics最新文献

英文 中文
Switchable photothermal conversion efficiency for reprogrammable actuation 可编程驱动的可切换光热转换效率
IF 14.6 1区 材料科学 Q1 Engineering Pub Date : 2023-10-20 DOI: 10.1038/s41528-023-00281-0
Yongcheng He, Haojun Liu, Jiajia Luo, Nuo Li, Lihua Li, Puxian Xiong, Jiulin Gan, Zhongmin Yang
Reprogrammable soft matter brings flexibility to soft robots so that they can display various motions, which is flourishing in soft robotics. However, the reprogramming of photoresponsive materials used in soft robots is time-consuming using existing methods. In this study, we promote a strategy for rapid reprogramming via switchable photothermal conversion efficiency (PCE). The liquid crystalline elastomers doped with semiconductor bismuth compounds (Bi-LCE) used in this work exhibited large photothermal actuation with over 35% shrinkage in 5 s at high PCE state, which demonstrated little deformation at low PCE state. Furthermore, the material was capable of being reprogrammed up to 10 times, with only 20 min required for one PCE reversible switch. Based on this switchable PCE effect, the same Bi-LCE film displayed various shape changes through different programmable pattern. Additionally, a reprogrammable hollow tube made of PCE reprogrammable materials could tune the diameter, cross-section configuration, and surface morphology, which was crucial for microfluidics field. Reprogrammable materials provide endless possibilities for reusability and sustainability in robotics.
可编程软物质为软机器人带来了灵活性,使其能够显示各种运动,这在软机器人中蓬勃发展。然而,使用现有方法对软机器人中使用的光响应材料进行重新编程是耗时的。在这项研究中,我们提出了一种通过可切换光热转换效率(PCE)快速重新编程的策略。本工作中使用的掺杂有半导体铋化合物(Bi-LCE)的液晶弹性体在5 其在低PCE状态下表现出小的变形。此外,该材料能够被重新编程多达10次,只有20次 一个PCE可逆开关所需的最小值。基于这种可切换的PCE效应,同一Bi-LCE薄膜通过不同的可编程图案显示出不同的形状变化。此外,由PCE可重编程材料制成的可重编程中空管可以调节直径、横截面配置和表面形态,这对微流体领域至关重要。可重新编程的材料为机器人的可重复使用性和可持续性提供了无限的可能性。
{"title":"Switchable photothermal conversion efficiency for reprogrammable actuation","authors":"Yongcheng He, Haojun Liu, Jiajia Luo, Nuo Li, Lihua Li, Puxian Xiong, Jiulin Gan, Zhongmin Yang","doi":"10.1038/s41528-023-00281-0","DOIUrl":"10.1038/s41528-023-00281-0","url":null,"abstract":"Reprogrammable soft matter brings flexibility to soft robots so that they can display various motions, which is flourishing in soft robotics. However, the reprogramming of photoresponsive materials used in soft robots is time-consuming using existing methods. In this study, we promote a strategy for rapid reprogramming via switchable photothermal conversion efficiency (PCE). The liquid crystalline elastomers doped with semiconductor bismuth compounds (Bi-LCE) used in this work exhibited large photothermal actuation with over 35% shrinkage in 5 s at high PCE state, which demonstrated little deformation at low PCE state. Furthermore, the material was capable of being reprogrammed up to 10 times, with only 20 min required for one PCE reversible switch. Based on this switchable PCE effect, the same Bi-LCE film displayed various shape changes through different programmable pattern. Additionally, a reprogrammable hollow tube made of PCE reprogrammable materials could tune the diameter, cross-section configuration, and surface morphology, which was crucial for microfluidics field. Reprogrammable materials provide endless possibilities for reusability and sustainability in robotics.","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41528-023-00281-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71491803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skin-integrated, biocompatible, and stretchable silicon microneedle electrode for long-term EMG monitoring in motion scenario 皮肤集成、生物相容、可拉伸的硅微针电极,用于运动场景中的长期EMG监测
IF 14.6 1区 材料科学 Q1 Engineering Pub Date : 2023-10-17 DOI: 10.1038/s41528-023-00279-8
Huawei Ji, Mingyu Wang, Yutong Wang, Zhouheng Wang, Yinji Ma, Lanlan Liu, Honglei Zhou, Ze Xu, Xian Wang, Ying Chen, Xue Feng
Electromyography (EMG) signal is the electrical potential generated by contracting muscle cells. Long-term and accurate EMG monitoring is desirable for neuromuscular function assessment in clinical and the human–computer interfaces. Herein, we report a skin-integrated, biocompatible, and stretchable silicon microneedle electrode (SSME) inspired by the plant thorns. The silicon microneedles are half encapsulated by the polyimide (PI) to enhance the adaptability to deformation and resistance to fatigue. Thorn-like SSME is realized by the semi-additive method with a stretchability of not less than 36%. The biocompatibility of SSME has been verified using cytotoxicity tests. EMG monitoring in motion and long-term has been conducted to demonstrate the feasibility and performance of the SSME, which is compared with a commercial wet electrode. Hopefully, the strategies reported here can lead to accurate and long-term EMG monitoring, facilitating an effective and reliable human–computer interface.
肌电图(EMG)信号是肌肉细胞收缩产生的电位。临床和人机界面中的神经肌肉功能评估需要长期准确的肌电图监测。在此,我们报道了一种受植物刺启发的皮肤集成、生物相容和可拉伸的硅微针电极(SSME)。硅微针被聚酰亚胺(PI)半包封,以增强对变形的适应性和抗疲劳性。刺状SSME通过具有不小于36%的拉伸性的半加成法实现。SSME的生物相容性已通过细胞毒性试验得到验证。已经进行了运动和长期的EMG监测,以证明SSME的可行性和性能,并将其与商用湿电极进行了比较。希望本文报道的策略能够实现准确和长期的肌电图监测,促进有效和可靠的人机界面。
{"title":"Skin-integrated, biocompatible, and stretchable silicon microneedle electrode for long-term EMG monitoring in motion scenario","authors":"Huawei Ji, Mingyu Wang, Yutong Wang, Zhouheng Wang, Yinji Ma, Lanlan Liu, Honglei Zhou, Ze Xu, Xian Wang, Ying Chen, Xue Feng","doi":"10.1038/s41528-023-00279-8","DOIUrl":"10.1038/s41528-023-00279-8","url":null,"abstract":"Electromyography (EMG) signal is the electrical potential generated by contracting muscle cells. Long-term and accurate EMG monitoring is desirable for neuromuscular function assessment in clinical and the human–computer interfaces. Herein, we report a skin-integrated, biocompatible, and stretchable silicon microneedle electrode (SSME) inspired by the plant thorns. The silicon microneedles are half encapsulated by the polyimide (PI) to enhance the adaptability to deformation and resistance to fatigue. Thorn-like SSME is realized by the semi-additive method with a stretchability of not less than 36%. The biocompatibility of SSME has been verified using cytotoxicity tests. EMG monitoring in motion and long-term has been conducted to demonstrate the feasibility and performance of the SSME, which is compared with a commercial wet electrode. Hopefully, the strategies reported here can lead to accurate and long-term EMG monitoring, facilitating an effective and reliable human–computer interface.","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41528-023-00279-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71491800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scalable and eco-friendly flexible loudspeakers for distributed human-machine interactions 可扩展且环保的柔性扬声器,实现分布式人机交互
IF 14.6 1区 材料科学 Q1 Engineering Pub Date : 2023-10-07 DOI: 10.1038/s41528-023-00278-9
Yucong Pi, Qiutong Liu, Zhaoyang Li, Dazhe Zhao, Kaijun Zhang, Zhirui Liu, Bingpu Zhou, Iek Man Lei, Yuan Ma, Junwen Zhong
Flexible loudspeakers that can be easily distributed in the surrounding environment are essential for creating immersive experiences in human-machine interactions, as these devices can transmit acoustic information conveniently. In this paper, we present a flexible electret loudspeaker that offers numerous benefits, such as eco-friendly, easy fabrication, flexible customization, strong durability, and excellent outputs. The output sound pressure level (SPL) and frequency response characteristic are optimized according to the simulation and experiment results. At a distance of 50 meters, a large-size loudspeaker (50 × 40 cm2) can produce an average SPL of 60 dB (normal SPL range of human voices is between 40 to 70 dB). The frequency response of our loudspeaker is high and relatively consistent up to 15 kHz, which covers the normal frequency range of human voices (<8 kHz). As demonstrated in this work, our loudspeakers can be used for scalable applications, such as being integrated with curtains or hung up like posters, offering a promising and practical solution for creating better human-machine interaction experiences.
可以轻松分布在周围环境中的灵活扬声器对于在人机交互中创造身临其境的体验至关重要,因为这些设备可以方便地传输声学信息。在本文中,我们提出了一种柔性驻极体扬声器,它具有许多优点,如环保、易于制造、灵活定制、坚固耐用和出色的输出。根据仿真和实验结果,对输出声压级和频率响应特性进行了优化。在50米的距离处,一个大尺寸扬声器(50 × 40 cm2)可以产生60的平均SPL dB(人声的正常SPL范围在40到70之间 dB)。我们扬声器的频率响应很高,并且相对一致,最高可达15 kHz,其覆盖人声的正常频率范围(<;8 kHz)。正如这项工作所展示的,我们的扬声器可以用于可扩展的应用,例如与窗帘集成或像海报一样挂起来,为创造更好的人机交互体验提供了一个有前景和实用的解决方案。
{"title":"Scalable and eco-friendly flexible loudspeakers for distributed human-machine interactions","authors":"Yucong Pi,&nbsp;Qiutong Liu,&nbsp;Zhaoyang Li,&nbsp;Dazhe Zhao,&nbsp;Kaijun Zhang,&nbsp;Zhirui Liu,&nbsp;Bingpu Zhou,&nbsp;Iek Man Lei,&nbsp;Yuan Ma,&nbsp;Junwen Zhong","doi":"10.1038/s41528-023-00278-9","DOIUrl":"10.1038/s41528-023-00278-9","url":null,"abstract":"Flexible loudspeakers that can be easily distributed in the surrounding environment are essential for creating immersive experiences in human-machine interactions, as these devices can transmit acoustic information conveniently. In this paper, we present a flexible electret loudspeaker that offers numerous benefits, such as eco-friendly, easy fabrication, flexible customization, strong durability, and excellent outputs. The output sound pressure level (SPL) and frequency response characteristic are optimized according to the simulation and experiment results. At a distance of 50 meters, a large-size loudspeaker (50 × 40 cm2) can produce an average SPL of 60 dB (normal SPL range of human voices is between 40 to 70 dB). The frequency response of our loudspeaker is high and relatively consistent up to 15 kHz, which covers the normal frequency range of human voices (&lt;8 kHz). As demonstrated in this work, our loudspeakers can be used for scalable applications, such as being integrated with curtains or hung up like posters, offering a promising and practical solution for creating better human-machine interaction experiences.","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41528-023-00278-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71491795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Resilient conductive membrane synthesized by in-situ polymerisation for wearable non-invasive electronics on moving appendages of cyborg insect 作者更正:通过原位聚合合成弹性导电膜,用于在半机械昆虫活动附肢上安装可穿戴无创电子设备
IF 14.6 1区 材料科学 Q1 Engineering Pub Date : 2023-09-20 DOI: 10.1038/s41528-023-00277-w
Qifeng Lin, Rui Li, Feilong Zhang, Kazuki Kai, Zong Chen Ong, Xiaodong Chen, Hirotaka Sato
{"title":"Author Correction: Resilient conductive membrane synthesized by in-situ polymerisation for wearable non-invasive electronics on moving appendages of cyborg insect","authors":"Qifeng Lin,&nbsp;Rui Li,&nbsp;Feilong Zhang,&nbsp;Kazuki Kai,&nbsp;Zong Chen Ong,&nbsp;Xiaodong Chen,&nbsp;Hirotaka Sato","doi":"10.1038/s41528-023-00277-w","DOIUrl":"10.1038/s41528-023-00277-w","url":null,"abstract":"","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41528-023-00277-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136308417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skin-interfaced colorimetric microfluidic devices for on-demand sweat analysis 用于按需汗液分析的皮肤界面比色微流控装置
IF 14.6 1区 材料科学 Q1 Engineering Pub Date : 2023-09-01 DOI: 10.1038/s41528-023-00275-y
Weiyi Liu, Huanyu Cheng, Xiufeng Wang
As sweat biomarker levels are continuously changing over metabolism and daily activities, pathological and physiological processes can be dynamically analyzed by wearable devices. The colorimetric skin-interfaced microfluidic devices that do not have external circuit modules exhibit enhanced deformability with a small footprint. However, it is difficult to achieve sampling over time and self-feedback for closed-loop systems. This review summarizes recent advances in microfluidic valves for biofluid management and chrono-sampling, as well as active triggers in microfluidics self-feedback. After enumerating the current limitations in temporal resolution and reliability, we further point out a few potential feasible strategies for future developments.
由于汗液中的生物标志物水平会随着新陈代谢和日常活动而不断变化,因此可穿戴设备可对病理和生理过程进行动态分析。无外部电路模块的皮肤比色微流控设备具有更强的可变形性,且占地面积小。然而,闭环系统很难实现随时间采样和自我反馈。本综述总结了用于生物流体管理和计时采样的微流体阀门以及微流体自反馈主动触发器的最新进展。在列举了目前在时间分辨率和可靠性方面的局限性之后,我们进一步指出了未来发展的一些潜在可行策略。
{"title":"Skin-interfaced colorimetric microfluidic devices for on-demand sweat analysis","authors":"Weiyi Liu,&nbsp;Huanyu Cheng,&nbsp;Xiufeng Wang","doi":"10.1038/s41528-023-00275-y","DOIUrl":"10.1038/s41528-023-00275-y","url":null,"abstract":"As sweat biomarker levels are continuously changing over metabolism and daily activities, pathological and physiological processes can be dynamically analyzed by wearable devices. The colorimetric skin-interfaced microfluidic devices that do not have external circuit modules exhibit enhanced deformability with a small footprint. However, it is difficult to achieve sampling over time and self-feedback for closed-loop systems. This review summarizes recent advances in microfluidic valves for biofluid management and chrono-sampling, as well as active triggers in microfluidics self-feedback. After enumerating the current limitations in temporal resolution and reliability, we further point out a few potential feasible strategies for future developments.","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41528-023-00275-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48279818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resilient conductive membrane synthesized by in-situ polymerisation for wearable non-invasive electronics on moving appendages of cyborg insect 通过原位聚合合成弹性导电膜,用于在机械昆虫的活动附肢上安装可穿戴无创电子设备
IF 14.6 1区 材料科学 Q1 Engineering Pub Date : 2023-09-01 DOI: 10.1038/s41528-023-00274-z
Qifeng Lin, Rui Li, Feilong Zhang, Kazuki Kai, Zong Chen Ong, Xiaodong Chen, Hirotaka Sato
By leveraging their high mobility and small size, insects have been combined with microcontrollers to build up cyborg insects for various practical applications. Unfortunately, all current cyborg insects rely on implanted electrodes to control their movement, which causes irreversible damage to their organs and muscles. Here, we develop a non-invasive method for cyborg insects to address above issues, using a conformal electrode with an in-situ polymerized ion-conducting layer and an electron-conducting layer. The neural and locomotion responses to the electrical inductions verify the efficient communication between insects and controllers by the non-invasive method. The precise “S” line following of the cyborg insect further demonstrates its potential in practical navigation. The conformal non-invasive electrodes keep the intactness of the insects while controlling their motion. With the antennae, important olfactory organs of insects preserved, the cyborg insect, in the future, may be endowed with abilities to detect the surrounding environment.
利用昆虫的高机动性和体积小的特点,人们将昆虫与微控制器结合起来,制造出了各种实际应用的半机械昆虫。遗憾的是,目前所有的半机械昆虫都依靠植入电极来控制运动,这对它们的器官和肌肉造成了不可逆的损伤。为了解决上述问题,我们开发了一种非侵入性的半机械昆虫方法,使用一种带有原位聚合离子导电层和电子导电层的保形电极。昆虫对电感应的神经和运动反应验证了这种非侵入式方法在昆虫和控制器之间的高效通信。电子昆虫精确的 "S "线跟踪进一步证明了其在实际导航中的潜力。保形非侵入式电极在控制昆虫运动的同时保持了昆虫的完整性。由于保留了昆虫的触角和重要的嗅觉器官,半机械昆虫将来可能具有探测周围环境的能力。
{"title":"Resilient conductive membrane synthesized by in-situ polymerisation for wearable non-invasive electronics on moving appendages of cyborg insect","authors":"Qifeng Lin,&nbsp;Rui Li,&nbsp;Feilong Zhang,&nbsp;Kazuki Kai,&nbsp;Zong Chen Ong,&nbsp;Xiaodong Chen,&nbsp;Hirotaka Sato","doi":"10.1038/s41528-023-00274-z","DOIUrl":"10.1038/s41528-023-00274-z","url":null,"abstract":"By leveraging their high mobility and small size, insects have been combined with microcontrollers to build up cyborg insects for various practical applications. Unfortunately, all current cyborg insects rely on implanted electrodes to control their movement, which causes irreversible damage to their organs and muscles. Here, we develop a non-invasive method for cyborg insects to address above issues, using a conformal electrode with an in-situ polymerized ion-conducting layer and an electron-conducting layer. The neural and locomotion responses to the electrical inductions verify the efficient communication between insects and controllers by the non-invasive method. The precise “S” line following of the cyborg insect further demonstrates its potential in practical navigation. The conformal non-invasive electrodes keep the intactness of the insects while controlling their motion. With the antennae, important olfactory organs of insects preserved, the cyborg insect, in the future, may be endowed with abilities to detect the surrounding environment.","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41528-023-00274-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135048269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring 用于模块化癌症治疗和实时监测的完全植入式无电池无线光电系统
IF 14.6 1区 材料科学 Q1 Engineering Pub Date : 2023-08-28 DOI: 10.1038/s41528-023-00276-x
Kiho Kim, In Sik Min, Tae Hee Kim, Do Hyeon Kim, Seungwon Hwang, Kyowon Kang, Kyubeen Kim, Sangun Park, Jongmin Lee, Young Uk Cho, Jung Woo Lee, Woon-Hong Yeo, Young Min Song, Youngmee Jung, Ki Jun Yu
Photodynamic therapy (PDT) is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues, exhibit fewer side effects, and lack pain during treatments. Implantable PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive treatment. Existing implantable PDT systems, however, are not able to perform multiple functions simultaneously, such as modulating light intensity, measuring, and transmitting tumor-related data, resulting in the complexity of cancer treatment. Here, we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in real-time. This system exploits micro inorganic light-emitting diodes (μ-LED) that emit light with a wavelength of 624 nm, designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity of μ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation (2–3 weeks). The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments, ray-tracing simulation results, and a tumor xenograft mouse model in vivo. This all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.
光动力疗法(PDT)可选择性地破坏恶性组织,副作用小,治疗过程中无痛苦,作为新一代癌症治疗方法备受关注。为了解决传统光导疗法系统体积庞大、价格昂贵的问题,并实现连续和重复治疗,最近开发出了植入式光导疗法系统。然而,现有的植入式光导治疗系统无法同时实现多种功能,如调节光强度、测量和传输肿瘤相关数据,从而导致癌症治疗的复杂性。在这里,我们介绍了一种灵活、完全可植入的无线光电系统,该系统融合了光动力疗法和热疗技术,能够持续、有效地治疗癌症,并能实时监测肿瘤大小。该系统利用微型无机发光二极管(μ-LED)发出波长为 624 纳米的光,通过利用完全可编程的μ-LED 光强度,在长期植入过程中(2-3 周)通过硅光电晶体管精确监测肿瘤大小,从而避免影响周围正常组织。通过体外实验、射线追踪模拟结果和体内肿瘤异种移植小鼠模型,证实了我们的系统通过手机无线供电和数据传输同时进行癌症治疗和肿瘤大小监测功能的优越性。这种用于癌症治疗的一体化单一系统不仅能有效治疗组织深部的肿瘤,还能精确、持续地实时监测肿瘤大小。
{"title":"Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring","authors":"Kiho Kim,&nbsp;In Sik Min,&nbsp;Tae Hee Kim,&nbsp;Do Hyeon Kim,&nbsp;Seungwon Hwang,&nbsp;Kyowon Kang,&nbsp;Kyubeen Kim,&nbsp;Sangun Park,&nbsp;Jongmin Lee,&nbsp;Young Uk Cho,&nbsp;Jung Woo Lee,&nbsp;Woon-Hong Yeo,&nbsp;Young Min Song,&nbsp;Youngmee Jung,&nbsp;Ki Jun Yu","doi":"10.1038/s41528-023-00276-x","DOIUrl":"10.1038/s41528-023-00276-x","url":null,"abstract":"Photodynamic therapy (PDT) is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues, exhibit fewer side effects, and lack pain during treatments. Implantable PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive treatment. Existing implantable PDT systems, however, are not able to perform multiple functions simultaneously, such as modulating light intensity, measuring, and transmitting tumor-related data, resulting in the complexity of cancer treatment. Here, we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in real-time. This system exploits micro inorganic light-emitting diodes (μ-LED) that emit light with a wavelength of 624 nm, designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity of μ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation (2–3 weeks). The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments, ray-tracing simulation results, and a tumor xenograft mouse model in vivo. This all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41528-023-00276-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46801477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A soft, high-density neuroelectronic array 软性高密度神经电子阵列
IF 14.6 1区 材料科学 Q1 Engineering Pub Date : 2023-08-22 DOI: 10.1038/s41528-023-00271-2
Kyung Jin Seo, Mackenna Hill, Jaehyeon Ryu, Chia-Han Chiang, Iakov Rachinskiy, Yi Qiang, Dongyeol Jang, Michael Trumpis, Charles Wang, Jonathan Viventi, Hui Fang
Techniques to study brain activities have evolved dramatically, yet tremendous challenges remain in acquiring high-throughput electrophysiological recordings minimally invasively. Here, we develop an integrated neuroelectronic array that is filamentary, high-density and flexible. Specifically, with a design of single-transistor multiplexing and current sensing, the total 256 neuroelectrodes achieve only a 2.3 × 0.3 mm2 area, unprecedentedly on a flexible substrate. A single-transistor multiplexing acquisition circuit further reduces noise from the electrodes, decreases the footprint of each pixel, and potentially increases the device’s lifetime. The filamentary neuroelectronic array also integrates with a rollable contact pad design, allowing the device to be injected through a syringe, enabling potential minimally invasive array delivery. Successful acute auditory experiments in rats validate the ability of the array to record neural signals with high tone decoding accuracy. Together, these results establish soft, high-density neuroelectronic arrays as promising devices for neuroscience research and clinical applications.
研究大脑活动的技术已经有了长足的发展,但在以微创方式获取高通量电生理记录方面仍面临巨大挑战。在这里,我们开发了一种丝状、高密度和灵活的集成神经电子阵列。具体来说,通过单晶体管复用和电流感应设计,总共 256 个神经电极的面积仅为 2.3 × 0.3 平方毫米,这在柔性基底上是前所未有的。单晶体管多路复用采集电路进一步降低了来自电极的噪声,减少了每个像素的占地面积,并有可能延长设备的使用寿命。丝状神经电子阵列还集成了可滚动接触垫设计,允许通过注射器注射该装置,从而实现潜在的微创阵列传输。在大鼠身上成功进行的急性听觉实验验证了该阵列记录神经信号的能力,具有很高的音调解码精度。这些研究成果共同确立了软性高密度神经电子阵列作为神经科学研究和临床应用设备的前景。
{"title":"A soft, high-density neuroelectronic array","authors":"Kyung Jin Seo,&nbsp;Mackenna Hill,&nbsp;Jaehyeon Ryu,&nbsp;Chia-Han Chiang,&nbsp;Iakov Rachinskiy,&nbsp;Yi Qiang,&nbsp;Dongyeol Jang,&nbsp;Michael Trumpis,&nbsp;Charles Wang,&nbsp;Jonathan Viventi,&nbsp;Hui Fang","doi":"10.1038/s41528-023-00271-2","DOIUrl":"10.1038/s41528-023-00271-2","url":null,"abstract":"Techniques to study brain activities have evolved dramatically, yet tremendous challenges remain in acquiring high-throughput electrophysiological recordings minimally invasively. Here, we develop an integrated neuroelectronic array that is filamentary, high-density and flexible. Specifically, with a design of single-transistor multiplexing and current sensing, the total 256 neuroelectrodes achieve only a 2.3 × 0.3 mm2 area, unprecedentedly on a flexible substrate. A single-transistor multiplexing acquisition circuit further reduces noise from the electrodes, decreases the footprint of each pixel, and potentially increases the device’s lifetime. The filamentary neuroelectronic array also integrates with a rollable contact pad design, allowing the device to be injected through a syringe, enabling potential minimally invasive array delivery. Successful acute auditory experiments in rats validate the ability of the array to record neural signals with high tone decoding accuracy. Together, these results establish soft, high-density neuroelectronic arrays as promising devices for neuroscience research and clinical applications.","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487278/pdf/nihms-1926792.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10605698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in flexible noninvasive electrodes for surface electromyography acquisition 柔性无创表面肌电采集电极的最新进展
IF 14.6 1区 材料科学 Q1 Engineering Pub Date : 2023-08-16 DOI: 10.1038/s41528-023-00273-0
Lian Cheng, Jun Li, Aiying Guo, Jianhua Zhang
Surface electromyography (sEMG) is used to detect and analyze human muscle biopotential. Recently, flexible noninvasive electrodes (FNEs) have emerged to extract bioelectrical signals from individual bodies. For FNEs to be deployed as a central component of physiological signal acquisition, the quest for elevated signal-to-noise ratio and density is compelling owing to the small amplitude of sEMG. Herein, we review recent progress in FNEs for sEMG acquisition. We summarize the needed properties of FNEs, compare the differences between passive electrodes and active electrodes and exemplify applications of FNEs. We also conclude the current challenges and future opportunities in sEMG acquisition.
表面肌电图(sEMG)用于检测和分析人体肌肉的生物电位。最近,出现了柔性无创电极(FNE),用于从人体提取生物电信号。由于 sEMG 的振幅较小,要将 FNE 用作生理信号采集的核心部件,就必须提高信噪比和密度。在此,我们回顾了用于采集 sEMG 的 FNE 的最新进展。我们总结了 FNE 所需的特性,比较了无源电极和有源电极之间的差异,并举例说明了 FNE 的应用。此外,我们还总结了当前在 sEMG 采集方面面临的挑战和未来的机遇。
{"title":"Recent advances in flexible noninvasive electrodes for surface electromyography acquisition","authors":"Lian Cheng,&nbsp;Jun Li,&nbsp;Aiying Guo,&nbsp;Jianhua Zhang","doi":"10.1038/s41528-023-00273-0","DOIUrl":"10.1038/s41528-023-00273-0","url":null,"abstract":"Surface electromyography (sEMG) is used to detect and analyze human muscle biopotential. Recently, flexible noninvasive electrodes (FNEs) have emerged to extract bioelectrical signals from individual bodies. For FNEs to be deployed as a central component of physiological signal acquisition, the quest for elevated signal-to-noise ratio and density is compelling owing to the small amplitude of sEMG. Herein, we review recent progress in FNEs for sEMG acquisition. We summarize the needed properties of FNEs, compare the differences between passive electrodes and active electrodes and exemplify applications of FNEs. We also conclude the current challenges and future opportunities in sEMG acquisition.","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41528-023-00273-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45722090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
270 nm ultra-thin self-adhesive conformable and long-term air-stable complimentary organic transistors and amplifiers 270纳米超薄不干胶兼容和长期空气稳定赠送有机晶体管和放大器
IF 14.6 1区 材料科学 Q1 Engineering Pub Date : 2023-08-11 DOI: 10.1038/s41528-023-00267-y
Mohammad Javad Mirshojaeian Hosseini, Yi Yang, Walter Kruger, Tomoyuki Yokota, Sunghoon Lee, Takao Someya, Robert A. Nawrocki
Lightweight, flexible, and conformal bioelectronics are essential for wearable technologies. This paper introduces 270 nm thin organic electronics amplifying circuits that are self-adhesive, skin conformal, and long-term air-stable. This report studies the effect of total device thickness, namely 3 μm and 270 nm devices, on the characterization of organic devices before and after buckling, the longevity of organic field-effect transistors (OFETs) over 5 years, and the lamination of OFETs on the human skin. A single-stage organic complementary inverter and a pseudo-complementary amplifier are fabricated to compare their electrical characteristics, with amplification gains of 10 and 64, respectively. Finally, the study demonstrates a five-stage organic complementary inverter can successfully amplify artificial electromyogram and electrocardiogram signals with gains of 1000 and 1088, respectively.
轻便、灵活、保形的生物电子器件对可穿戴技术至关重要。本文介绍的 270 纳米薄型有机电子放大电路具有自粘性、皮肤保形性和长期空气稳定性。该报告研究了总器件厚度(即 3 μm 和 270 nm 器件)对有机器件降压前后特性的影响、有机场效应晶体管(OFET)5 年的寿命以及 OFET 在人体皮肤上的层压。研究还制作了单级有机互补逆变器和伪互补放大器,以比较它们的电气特性,其放大增益分别为 10 和 64。最后,研究证明五级有机互补逆变器可以成功放大人工肌电图和心电图信号,增益分别为 1000 和 1088。
{"title":"270 nm ultra-thin self-adhesive conformable and long-term air-stable complimentary organic transistors and amplifiers","authors":"Mohammad Javad Mirshojaeian Hosseini,&nbsp;Yi Yang,&nbsp;Walter Kruger,&nbsp;Tomoyuki Yokota,&nbsp;Sunghoon Lee,&nbsp;Takao Someya,&nbsp;Robert A. Nawrocki","doi":"10.1038/s41528-023-00267-y","DOIUrl":"10.1038/s41528-023-00267-y","url":null,"abstract":"Lightweight, flexible, and conformal bioelectronics are essential for wearable technologies. This paper introduces 270 nm thin organic electronics amplifying circuits that are self-adhesive, skin conformal, and long-term air-stable. This report studies the effect of total device thickness, namely 3 μm and 270 nm devices, on the characterization of organic devices before and after buckling, the longevity of organic field-effect transistors (OFETs) over 5 years, and the lamination of OFETs on the human skin. A single-stage organic complementary inverter and a pseudo-complementary amplifier are fabricated to compare their electrical characteristics, with amplification gains of 10 and 64, respectively. Finally, the study demonstrates a five-stage organic complementary inverter can successfully amplify artificial electromyogram and electrocardiogram signals with gains of 1000 and 1088, respectively.","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41528-023-00267-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45033899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
npj Flexible Electronics
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1