Flexible sensing array integrated with multiple sensors is an attractive approach for flight parameter detection. However, the poor resolution of flexible sensors and time-consuming neural network processes mitigate their accuracy and adaptability in predicting flight parameters. Here we present an ultra-thin flexible sensing patch with a new configuration, comprising a differential pressure sensor array and a vector flow velocity sensor. The capacitive differential pressure sensor array is fabricated by a multilayer polyimide bonding technique, reaching a resolution of 0.14 Pa. To solve flight parameters with the flexible sensing patch, we develop an analytical pressure-velocity fusion algorithm, enabling fast response and high accuracy in flight parameter detection. The average errors in calculating the angle of attack, angle of sideslip, and airspeed are 0.22°, 0.35°, and 0.73 m s−1, respectively. The high-resolution flexible sensors and novel analytical pressure-velocity fusion algorithm pave the way for flexible sensing patch-based air data sensing techniques.
多传感器集成柔性传感阵列是一种有吸引力的飞行参数检测方法。然而,柔性传感器分辨率较差,神经网络处理耗时,降低了其预测飞行参数的准确性和适应性。在这里,我们提出了一种具有新配置的超薄柔性传感贴片,包括一个差压传感器阵列和一个矢量流速传感器。该电容式差压传感器阵列采用多层聚酰亚胺键合技术制备,分辨率为0.14 Pa。为了利用柔性传感贴片求解飞行参数,我们开发了一种解析式压力-速度融合算法,实现了快速响应和高精度的飞行参数检测。计算迎角、侧滑角和空速的平均误差分别为0.22°、0.35°和0.73 m s−1。高分辨率柔性传感器和新型分析压力-速度融合算法为基于柔性传感贴片的空气数据传感技术铺平了道路。
{"title":"An analytical pressure-velocity fusion algorithm-empowered flexible sensing patch for flight parameter detection","authors":"Yunfan Li, Zihao Dong, Zheng Gong, Zhiqiang Ma, Xin Ke, Tianyu Sheng, Xiaochang Yang, Xilun Ding, Yonggang Jiang","doi":"10.1038/s41528-025-00442-3","DOIUrl":"https://doi.org/10.1038/s41528-025-00442-3","url":null,"abstract":"<p>Flexible sensing array integrated with multiple sensors is an attractive approach for flight parameter detection. However, the poor resolution of flexible sensors and time-consuming neural network processes mitigate their accuracy and adaptability in predicting flight parameters. Here we present an ultra-thin flexible sensing patch with a new configuration, comprising a differential pressure sensor array and a vector flow velocity sensor. The capacitive differential pressure sensor array is fabricated by a multilayer polyimide bonding technique, reaching a resolution of 0.14 Pa. To solve flight parameters with the flexible sensing patch, we develop an analytical pressure-velocity fusion algorithm, enabling fast response and high accuracy in flight parameter detection. The average errors in calculating the angle of attack, angle of sideslip, and airspeed are 0.22°, 0.35°, and 0.73 m s<sup>−1</sup>, respectively. The high-resolution flexible sensors and novel analytical pressure-velocity fusion algorithm pave the way for flexible sensing patch-based air data sensing techniques.</p>","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":"90 1","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144712355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Organic electrochemical transistors (OECTs) based on poly(3,4-ethylenedioxythiophene) (PEDOT) have been extensively studied, yet devices fabricated via electropolymerization remain underexplored in terms of the underlying ionic dynamics and the potential for flexible integration. In this work, we demonstrate robust OECTs based on electropolymerized PEDOT, exhibiting negligible drain current degradation after 1000 cycles of operation in aqueous NaCl. Compared to inkjet-printed devices, they offer markedly superior cycling stability, which is further enhanced by the incorporation of the small anionic dopant ClO4−. We also show flexible, lightweight OECTs by electropolymerizing PEDOT on ultrathin parylene substrates, achieving stable performance under mechanical strain. Furthermore, Electrochemical Quartz Crystal Microbalance with Dissipation (EQCM-D) analysis reveals distinct ion transport behavior in PEDOT:ClO4, where dopant ejection dominates doping/dedoping process, unlike in PEDOT:PSS. This study underscores the advantages of electropolymerization and small-ion doping, offering new mechanistic insights and advancing the design of high-performance, flexible OECTs for bioelectronic applications.
{"title":"Robust and flexible organic electrochemical transistors enabled by electropolymerized PEDOT","authors":"Meijing Wang, Jiaxin Fan, Michel Bilodeau-Calame, Chihyeong Kim, Cheng-Ling Chiang, Ademar Fabricio Chaverri Segura, Vito Vurro, Ilaria Bargigia, Janine Mauzeroll, Fabio Cicoira","doi":"10.1038/s41528-025-00457-w","DOIUrl":"https://doi.org/10.1038/s41528-025-00457-w","url":null,"abstract":"<p>Organic electrochemical transistors (OECTs) based on poly(3,4-ethylenedioxythiophene) (PEDOT) have been extensively studied, yet devices fabricated via electropolymerization remain underexplored in terms of the underlying ionic dynamics and the potential for flexible integration. In this work, we demonstrate robust OECTs based on electropolymerized PEDOT, exhibiting negligible drain current degradation after 1000 cycles of operation in aqueous NaCl. Compared to inkjet-printed devices, they offer markedly superior cycling stability, which is further enhanced by the incorporation of the small anionic dopant ClO<sub>4</sub><sup>−</sup>. We also show flexible, lightweight OECTs by electropolymerizing PEDOT on ultrathin parylene substrates, achieving stable performance under mechanical strain. Furthermore, Electrochemical Quartz Crystal Microbalance with Dissipation (EQCM-D) analysis reveals distinct ion transport behavior in PEDOT:ClO<sub>4</sub>, where dopant ejection dominates doping/dedoping process, unlike in PEDOT:PSS. This study underscores the advantages of electropolymerization and small-ion doping, offering new mechanistic insights and advancing the design of high-performance, flexible OECTs for bioelectronic applications.</p>","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":"26 1","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144712214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-19DOI: 10.1038/s41528-025-00451-2
Dongik Kam, Girak Gwon, Yoonsang Ra, Donghan Lee, Yu-seop Kim, Joonmin Chae, Jong Woo Kim, Dongwhi Choi
Triboelectricity-driven acoustic transducers with various merits have demonstrated significant potential in energy harvesting and self-powered sensing. The transducers generally require additionally a spacer and a corresponding exquisite process for smooth operation, which provides an unnecessary interface between the elements. The exploration of a novel manufacturing approach for triboelectricity-driven acoustic transducers is warranted to resolve this issue. Here, Triboelectricity-driven Oscillating Nano-Electricity generator (TONE) developed via mechanically guided four-dimensional (4D) printing is introduced for acoustic energy harvesting and self-powered voice recognition. The mechanically buckled structure of the TONE facilitates its smooth oscillation by sound wave without the use of an additional spacer, enabling the TONE to exhibit outputs of 156 V and 10 μA. The output characteristics of the TONE are analyzed based on the acoustic-structural-triboelectric interaction mechanism. The TONE demonstrates practical versatility by providing power to commercial electronics from controlled/daily sound and being utilized in artificial intelligence-based human voice recognition sensors.
{"title":"Mechanically guided 4D printing of a triboelectricity-driven acoustic transducer for self-powered and intelligent voice recognition","authors":"Dongik Kam, Girak Gwon, Yoonsang Ra, Donghan Lee, Yu-seop Kim, Joonmin Chae, Jong Woo Kim, Dongwhi Choi","doi":"10.1038/s41528-025-00451-2","DOIUrl":"https://doi.org/10.1038/s41528-025-00451-2","url":null,"abstract":"<p>Triboelectricity-driven acoustic transducers with various merits have demonstrated significant potential in energy harvesting and self-powered sensing. The transducers generally require additionally a spacer and a corresponding exquisite process for smooth operation, which provides an unnecessary interface between the elements. The exploration of a novel manufacturing approach for triboelectricity-driven acoustic transducers is warranted to resolve this issue. Here, Triboelectricity-driven Oscillating Nano-Electricity generator (TONE) developed via mechanically guided four-dimensional (4D) printing is introduced for acoustic energy harvesting and self-powered voice recognition. The mechanically buckled structure of the TONE facilitates its smooth oscillation by sound wave without the use of an additional spacer, enabling the TONE to exhibit outputs of 156 V and 10 μA. The output characteristics of the TONE are analyzed based on the acoustic-structural-triboelectric interaction mechanism. The TONE demonstrates practical versatility by providing power to commercial electronics from controlled/daily sound and being utilized in artificial intelligence-based human voice recognition sensors.</p>","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":"109 1","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144664532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-18DOI: 10.1038/s41528-025-00452-1
Sang Gil Lee, Kyeong-Bin Kim, Hyesu Choi, Joo Hwan Shin, Chanho Jeong, Geonoh Choe, Gyan Raj Koirala, Jae-seung Shim, Yujin Mun, Young Gil Kim, Yei Hwan Jung, Eun-Ho Lee, Tae-il Kim
Integrating surface-mounted devices (SMDs) onto textiles remains a key challenge in wearable electronics due to textile surface irregularities and heat sensitivity. Conventional methods like soldering or anisotropic conductive films (ACFs) often fail in such environments. We introduce a low-stress anisotropic conductive adhesive (LS-ACA) composed of eutectic gallium–indium (EGaIn) liquid metal particles (LMPs) embedded in a pressure-sensitive SIS matrix. LS-ACA offers excellent electrical conductivity, mechanical flexibility, and durability under bending, stretching, and crumpling. Finite element analysis shows it reduces interfacial stress concentrations compared to soldering, maintaining uniform stress even under 10% strain. It achieves ultra-low contact resistance (1.5 mΩ at >64 wt% LMPs) and enables low-temperature bonding on diverse substrates. Moreover, LS-ACA supports over 10 reuse cycles without surface damage or performance loss. This scalable, reusable material offers a promising path for integrating electronics into fabrics, advancing sustainable and flexible wearable technologies.
{"title":"Mechanically stable, and reversible integration of microchips on textile: liquid metal-based anisotropic conductive adhesive","authors":"Sang Gil Lee, Kyeong-Bin Kim, Hyesu Choi, Joo Hwan Shin, Chanho Jeong, Geonoh Choe, Gyan Raj Koirala, Jae-seung Shim, Yujin Mun, Young Gil Kim, Yei Hwan Jung, Eun-Ho Lee, Tae-il Kim","doi":"10.1038/s41528-025-00452-1","DOIUrl":"https://doi.org/10.1038/s41528-025-00452-1","url":null,"abstract":"<p>Integrating surface-mounted devices (SMDs) onto textiles remains a key challenge in wearable electronics due to textile surface irregularities and heat sensitivity. Conventional methods like soldering or anisotropic conductive films (ACFs) often fail in such environments. We introduce a low-stress anisotropic conductive adhesive (LS-ACA) composed of eutectic gallium–indium (EGaIn) liquid metal particles (LMPs) embedded in a pressure-sensitive SIS matrix. LS-ACA offers excellent electrical conductivity, mechanical flexibility, and durability under bending, stretching, and crumpling. Finite element analysis shows it reduces interfacial stress concentrations compared to soldering, maintaining uniform stress even under 10% strain. It achieves ultra-low contact resistance (1.5 mΩ at >64 wt% LMPs) and enables low-temperature bonding on diverse substrates. Moreover, LS-ACA supports over 10 reuse cycles without surface damage or performance loss. This scalable, reusable material offers a promising path for integrating electronics into fabrics, advancing sustainable and flexible wearable technologies.</p>","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":"8 1","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-16DOI: 10.1038/s41528-025-00426-3
A. Mazzotta, S. Taccola, I. Cesini, M. Sanchez Sifuentes, R. A. Harris, V. Mattoli
Tactile displays often face challenges like high power consumption, bulky control systems, and limited portability, hindering their application in wearable technologies. This work presents a novel thermo-pneumatic tactile display that operates via localized heating of a small air volume, enabling low-voltage operation with standard batteries. Its fully portable design integrates control electronics into a wearable bracelet with Bluetooth activation, enhancing practicality. Mechanical tests demonstrated the device’s ability to generate forces exceeding 30 mN and displacements of tens of microns using pulsed signals with modulable durations and frequencies. User tests with voluntary participants confirmed its effectiveness as a tactile display, achieving 83% accuracy in recognizing Braille patterns. By addressing key limitations of traditional systems, this approach offers a promising solution for compact, low-power wearable tactile interfaces.
{"title":"Low-voltage wearable tactile display with thermo-pneumatic actuation","authors":"A. Mazzotta, S. Taccola, I. Cesini, M. Sanchez Sifuentes, R. A. Harris, V. Mattoli","doi":"10.1038/s41528-025-00426-3","DOIUrl":"https://doi.org/10.1038/s41528-025-00426-3","url":null,"abstract":"<p>Tactile displays often face challenges like high power consumption, bulky control systems, and limited portability, hindering their application in wearable technologies. This work presents a novel thermo-pneumatic tactile display that operates via localized heating of a small air volume, enabling low-voltage operation with standard batteries. Its fully portable design integrates control electronics into a wearable bracelet with Bluetooth activation, enhancing practicality. Mechanical tests demonstrated the device’s ability to generate forces exceeding 30 mN and displacements of tens of microns using pulsed signals with modulable durations and frequencies. User tests with voluntary participants confirmed its effectiveness as a tactile display, achieving 83% accuracy in recognizing Braille patterns. By addressing key limitations of traditional systems, this approach offers a promising solution for compact, low-power wearable tactile interfaces.</p>","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":"12 1","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-16DOI: 10.1038/s41528-025-00453-0
Hila Man, Paul F. Funk, Dvir Ben-Dov, Chen Bar-Haim, Bara Levit, Orlando Guntinas-Lichius, Yael Hanein
Facial muscles are uniquely attached to the skin, densely innervated, and exhibit complex co-activation patterns enabling fine motor control. Facial surface Electromyography (sEMG) effectively assesses muscle function, yet traditional setups require precise electrode placement and limit mobility due to mechanical artifacts. Signal extraction is hindered by noise and cross-talk from adjacent muscles, making it challenging to associate facial muscle activity with expressions. We leverage a novel 16-channel conformal sEMG system to extract meaningful electrophysiological data from 32 healthy individuals. By applying denoising and source separation techniques, we extracted independent components, clustered them spatially, and built a facial muscle atlas. Furthermore, we established a functional mapping between these clusters and specific muscle units, providing a framework for understanding facial muscle activation. Using this foundation, we demonstrated a deep-learning model to predict facial expressions. This approach enables precise, participant-specific monitoring with applications in medical rehabilitation and psychological research.
{"title":"Facial muscle mapping and expression prediction using a conformal surface-electromyography platform","authors":"Hila Man, Paul F. Funk, Dvir Ben-Dov, Chen Bar-Haim, Bara Levit, Orlando Guntinas-Lichius, Yael Hanein","doi":"10.1038/s41528-025-00453-0","DOIUrl":"https://doi.org/10.1038/s41528-025-00453-0","url":null,"abstract":"<p>Facial muscles are uniquely attached to the skin, densely innervated, and exhibit complex co-activation patterns enabling fine motor control. Facial surface Electromyography (sEMG) effectively assesses muscle function, yet traditional setups require precise electrode placement and limit mobility due to mechanical artifacts. Signal extraction is hindered by noise and cross-talk from adjacent muscles, making it challenging to associate facial muscle activity with expressions. We leverage a novel 16-channel conformal sEMG system to extract meaningful electrophysiological data from 32 healthy individuals. By applying denoising and source separation techniques, we extracted independent components, clustered them spatially, and built a facial muscle atlas. Furthermore, we established a functional mapping between these clusters and specific muscle units, providing a framework for understanding facial muscle activation. Using this foundation, we demonstrated a deep-learning model to predict facial expressions. This approach enables precise, participant-specific monitoring with applications in medical rehabilitation and psychological research.</p>","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":"2 1","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Conductive polymers like poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT: PSS) are key materials in bioelectronics, but balancing ultrahigh conductivity with long-term tissue contact stability remains a challenge. Here, we present a solvent-mediated solid-liquid interface doping strategy to engineer vertically phase-separated (VPS) PEDOT: PSS films. By adjusting thickness and doping solvents, a thicker PEDOT: PSS film with a strong VPS structure was achieved, featuring a higher PSS/PEDOT ratio on the surface and a lower ratio at the bottom. Doping the pristine film with a metastable liquid-liquid contact solution enables gradual PSS migration and a significant component gradient, yielding films with a hydrophilic surface and one of the highest reported conductivities ( ~ 8800 S cm−1) for bioelectronic devices. The films patterned by laser processing present high-fidelity signal acquisition, and excellent electrochemical stability. With low impedance and long-term biocompatibility, they are employed for real-time wearable and implantable sensors for electrophysiological monitoring, showcasing broad potentials in bioelectronics and human–machine interactions.
导电聚合物如聚(3,4-乙烯二氧噻吩):聚苯乙烯磺酸盐(PEDOT: PSS)是生物电子学中的关键材料,但平衡超高导电性和长期组织接触稳定性仍然是一个挑战。在这里,我们提出了一种溶剂介导的固液界面掺杂策略来设计垂直相分离(VPS) PEDOT: PSS薄膜。通过调整厚度和掺杂溶剂,得到了较厚的具有较强VPS结构的PEDOT: PSS膜,表面PSS/PEDOT比较高,底部PSS/PEDOT比较低。用亚稳液-液接触溶液掺杂原始膜,使PSS逐渐迁移和显著的组分梯度,得到具有亲水性表面和生物电子器件最高电导率之一(~ 8800 S cm−1)的膜。激光加工的薄膜具有高保真信号采集和优异的电化学稳定性。由于具有低阻抗和长期生物相容性,它们被用于电生理监测的实时可穿戴和可植入传感器,在生物电子学和人机交互方面显示出广阔的潜力。
{"title":"Highly conductive polymer with vertical phase separation for enhanced bioelectronic interfaces","authors":"Jiahuan Qiu, Yuyao Lu, Xinyuan Qian, Junxian Yao, Chengcan Han, Ziliang Wu, Hui Ye, Guorong Shan, Qiang Zheng, Kaichen Xu, Miao Du","doi":"10.1038/s41528-025-00441-4","DOIUrl":"https://doi.org/10.1038/s41528-025-00441-4","url":null,"abstract":"<p>Conductive polymers like poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT: PSS) are key materials in bioelectronics, but balancing ultrahigh conductivity with long-term tissue contact stability remains a challenge. Here, we present a solvent-mediated solid-liquid interface doping strategy to engineer vertically phase-separated (VPS) PEDOT: PSS films. By adjusting thickness and doping solvents, a thicker PEDOT: PSS film with a strong VPS structure was achieved, featuring a higher PSS/PEDOT ratio on the surface and a lower ratio at the bottom. Doping the pristine film with a metastable liquid-liquid contact solution enables gradual PSS migration and a significant component gradient, yielding films with a hydrophilic surface and one of the highest reported conductivities ( ~ 8800 S cm<sup>−1</sup>) for bioelectronic devices. The films patterned by laser processing present high-fidelity signal acquisition, and excellent electrochemical stability. With low impedance and long-term biocompatibility, they are employed for real-time wearable and implantable sensors for electrophysiological monitoring, showcasing broad potentials in bioelectronics and human–machine interactions.</p>","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":"12 1","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144640397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-14DOI: 10.1038/s41528-025-00447-y
Robin Kim, Yuxuan Liu, Jiaao Zhang, Chong Xie, Lan Luan
Neural representations arise from high-dimensional population activity, but current neuromodulation methods lack the precision to write information into the central nervous system at this complexity. In this perspective, we propose high-dimensional stimulation as an approach to better approximate natural neural codes for brain-machine interfaces. Key advancements in resolution, coverage, and safety are essential, with flexible microelectrode arrays offering a promising path toward precise synthetic neural codes.
{"title":"Towards precise synthetic neural codes: high-dimensional stimulation with flexible electrodes","authors":"Robin Kim, Yuxuan Liu, Jiaao Zhang, Chong Xie, Lan Luan","doi":"10.1038/s41528-025-00447-y","DOIUrl":"https://doi.org/10.1038/s41528-025-00447-y","url":null,"abstract":"<p>Neural representations arise from high-dimensional population activity, but current neuromodulation methods lack the precision to write information into the central nervous system at this complexity. In this perspective, we propose high-dimensional stimulation as an approach to better approximate natural neural codes for brain-machine interfaces. Key advancements in resolution, coverage, and safety are essential, with flexible microelectrode arrays offering a promising path toward precise synthetic neural codes.</p>","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":"38 1","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-12DOI: 10.1038/s41528-025-00445-0
Kai Liu, Yifan Xu, Xiaozhu Tian, Junxuan Liang, Zhihui Zhao, Jun Wang, Ziqi Zhang, Kewei Zhang, Song Yang
Aiming at the poor selectivity of electrically conductive metal-organic framework (EC-MOF) chemoresistive materials, this study develops a breakthrough room temperature ammonia (NH3) sensor by stacking ionically conductive MOF (IC-MOF) on an environmentally friendly biofabric. The synergism between ionic conductivity, tailored metal-nitrogen interaction, and fabric porosity enables the sensor with high response (R0/Rg = 14.7 towards 1 ppm NH3), low detection limit (36 ppb), and remarkable selectivity (coefficient >5.12 against common organic interferents). Notably, the optimized sensor yields a sixfold enhancement in response as compared with traditional EC-MOF powders. A linear regression model validated by fivefold cross-validation achieves 98.4% accuracy in NH3 concentration prediction, while the kNN classifier shows 96% accuracy in gas identification (tested on 192 samples). Preliminary clinical tests show that the sensor can clearly differentiate the exhaled NH3 signals of four patients with HE from those of healthy individuals, demonstrating the potential for non-invasive diagnostics.
{"title":"Stacking growth of ionically conductive MOF on biofabrics enables reliable NH3 sensor for hepatic encephalopathy diagnosis","authors":"Kai Liu, Yifan Xu, Xiaozhu Tian, Junxuan Liang, Zhihui Zhao, Jun Wang, Ziqi Zhang, Kewei Zhang, Song Yang","doi":"10.1038/s41528-025-00445-0","DOIUrl":"https://doi.org/10.1038/s41528-025-00445-0","url":null,"abstract":"<p>Aiming at the poor selectivity of electrically conductive metal-organic framework (EC-MOF) chemoresistive materials, this study develops a breakthrough room temperature ammonia (NH<sub>3</sub>) sensor by stacking ionically conductive MOF (IC-MOF) on an environmentally friendly biofabric. The synergism between ionic conductivity, tailored metal-nitrogen interaction, and fabric porosity enables the sensor with high response (<i>R</i><sub><i>0</i></sub>/<i>R</i><sub><i>g</i></sub> = 14.7 towards 1 ppm NH<sub>3</sub>), low detection limit (36 ppb), and remarkable selectivity (coefficient >5.12 against common organic interferents). Notably, the optimized sensor yields a sixfold enhancement in response as compared with traditional EC-MOF powders. A linear regression model validated by fivefold cross-validation achieves 98.4% accuracy in NH<sub>3</sub> concentration prediction, while the kNN classifier shows 96% accuracy in gas identification (tested on 192 samples). Preliminary clinical tests show that the sensor can clearly differentiate the exhaled NH<sub>3</sub> signals of four patients with HE from those of healthy individuals, demonstrating the potential for non-invasive diagnostics.</p>","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":"44 1","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-11DOI: 10.1038/s41528-025-00444-1
Gyeongho Lee, Sunwoo Jeong, Hyeonjung Kim, Yeong Jae Kim, Seyong Oh, Junhwan Choi, Hocheon Yoo
This study presents dual-mode memory transistor that accommodates memory and synaptic operations utilizing photoinduced charge trapping at the interface between poly(1,4-butanediol diacrylate) (pBDDA) and Parylene dielectric layer. Memory characteristics were implemented based on the photoresponsivity of dinaphtho[2,3-b:2′,3′-f]thieno[3,2-b]thiophene (DNTT), enabling instantaneous electron storage under combined optical and electrical inputs, with retention times up to 10,000 s. Meanwhile, synaptic characteristics were induced by gradual charge trapping via optical pulse stimulation. Synaptic plasticity was confirmed via the potentiation–depression curve, emulating key features of biological nervous system, namely short-term memory (STM) and long-term memory (LTM). Furthermore, the fingerprint recognition tasks highlighted identification and authentication abilities by incorporating our synaptic function into an artificial neural network (ANN). The dual-mode memory transistor, fabricated on a business card, showed excellent compatibility with flexible optoelectronics, maintaining stable memory and synaptic performance over 500 bending cycles with minimal changes in memory window, memory ratio, and potentiation–depression behavior.
{"title":"Photoresponsive dual-mode memory transistor for optoelectronic computing: charge storage and synaptic signal processing","authors":"Gyeongho Lee, Sunwoo Jeong, Hyeonjung Kim, Yeong Jae Kim, Seyong Oh, Junhwan Choi, Hocheon Yoo","doi":"10.1038/s41528-025-00444-1","DOIUrl":"https://doi.org/10.1038/s41528-025-00444-1","url":null,"abstract":"<p>This study presents dual-mode memory transistor that accommodates memory and synaptic operations utilizing photoinduced charge trapping at the interface between poly(1,4-butanediol diacrylate) (pBDDA) and Parylene dielectric layer. Memory characteristics were implemented based on the photoresponsivity of dinaphtho[2,3-<i>b</i>:2′,3′-<i>f</i>]thieno[3,2-<i>b</i>]thiophene (DNTT), enabling instantaneous electron storage under combined optical and electrical inputs, with retention times up to 10,000 s. Meanwhile, synaptic characteristics were induced by gradual charge trapping via optical pulse stimulation. Synaptic plasticity was confirmed via the potentiation–depression curve, emulating key features of biological nervous system, namely short-term memory (STM) and long-term memory (LTM). Furthermore, the fingerprint recognition tasks highlighted identification and authentication abilities by incorporating our synaptic function into an artificial neural network (ANN). The dual-mode memory transistor, fabricated on a business card, showed excellent compatibility with flexible optoelectronics, maintaining stable memory and synaptic performance over 500 bending cycles with minimal changes in memory window, memory ratio, and potentiation–depression behavior.</p>","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":"694 1","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}