There is no concord about indications for Fibular osteosynthesis in the extra articular fracture of Distal Tibia. A case report demonstrates that the Fibular fracture fixation increases the rotational stability in patient with Distal Tibia Fracture with reduce risk of malunion.
{"title":"Tibiofibular intussusception complicating fracture fixation of distal third both bone leg fracture","authors":"P. Velmurugan, RV Raghav, Mohan Kumar M","doi":"10.31254/jmr.2023.9301","DOIUrl":"https://doi.org/10.31254/jmr.2023.9301","url":null,"abstract":"There is no concord about indications for Fibular osteosynthesis in the extra articular fracture of Distal Tibia. A case report demonstrates that the Fibular fracture fixation increases the rotational stability in patient with Distal Tibia Fracture with reduce risk of malunion.","PeriodicalId":50132,"journal":{"name":"Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42986253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The main objective of this study is to elaborate the crucial effect of dioxins and phthalates on thyroid hormones such as tetraiodothyronine (T4) and tri-iodothyronine (T3) in body fluids. The literature evidences have been collected from Google Scholar, PubMed and Medline by using different key words. All literature evidences showed a drastic effect of dioxins and phthalates on the status of thyroid hormones. Hexachlorobenzene (HCB) is an environmental pollutant that increases activity of malic enzyme (ME) by increasing ME gene transcription. ME interact with aryl hydrocarbon receptors (AhR) and modulate the expression of genes with specific xenobiotic or DRE in their promoters that respond to dioxin. HCB increases activity of thyroid enzymes whose induction depends on thyroid hormone (TH) levels. Dioxin decreases T4 levels and increases TSH levels in neonatal plasma. Dioxin and HCB also causes various disorders in infants. Phthalates disrupt the thyroid hormones levels especially in pregnant women and infants through various mechanisms. Phthalates mainly decrease T4 levels and further studies are in process to describe exact mechanism.
{"title":"Induction of Thyroid Hormones Disruption by Exposure of Dioxins and Phthalates: A Comprehensive Review","authors":"A. Qader, Z. Batool, H. Tariq","doi":"10.31254/jmr.2023.9308","DOIUrl":"https://doi.org/10.31254/jmr.2023.9308","url":null,"abstract":"The main objective of this study is to elaborate the crucial effect of dioxins and phthalates on thyroid hormones such as tetraiodothyronine (T4) and tri-iodothyronine (T3) in body fluids. The literature evidences have been collected from Google Scholar, PubMed and Medline by using different key words. All literature evidences showed a drastic effect of dioxins and phthalates on the status of thyroid hormones. Hexachlorobenzene (HCB) is an environmental pollutant that increases activity of malic enzyme (ME) by increasing ME gene transcription. ME interact with aryl hydrocarbon receptors (AhR) and modulate the expression of genes with specific xenobiotic or DRE in their promoters that respond to dioxin. HCB increases activity of thyroid enzymes whose induction depends on thyroid hormone (TH) levels. Dioxin decreases T4 levels and increases TSH levels in neonatal plasma. Dioxin and HCB also causes various disorders in infants. Phthalates disrupt the thyroid hormones levels especially in pregnant women and infants through various mechanisms. Phthalates mainly decrease T4 levels and further studies are in process to describe exact mechanism.","PeriodicalId":50132,"journal":{"name":"Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49048557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akash K. Dumbhare, Nirmal M. Channe, S. Gajbhiye, S. Zodpey
Fungal infections are a worrisome threat to public health. We report a rare case of a 75-year-old male patient presented to the Ear, Nose, and Throat (ENT) Outpatient Department (OPD) with chief complaints of pus discharge from the left nose. The patient was already diagnosed with rhino orbital mucormycosis in July 2021. The patient had a history of stroke 1 year ago and is a known case of diabetes mellitus type 2 and systemic hypertension and is on medications. This case is extremely rare in Indian healthcare settings and can have an extensive impact on multiple organs.
{"title":"Sporobolomyces salmonicolor Infection in a Type 2 Diabetic Patient with a History of Rhino Orbital Mucormycosis and Stroke: A Rare Case Report from Maharashtra, India","authors":"Akash K. Dumbhare, Nirmal M. Channe, S. Gajbhiye, S. Zodpey","doi":"10.31254/jmr.2023.9302","DOIUrl":"https://doi.org/10.31254/jmr.2023.9302","url":null,"abstract":"Fungal infections are a worrisome threat to public health. We report a rare case of a 75-year-old male patient presented to the Ear, Nose, and Throat (ENT) Outpatient Department (OPD) with chief complaints of pus discharge from the left nose. The patient was already diagnosed with rhino orbital mucormycosis in July 2021. The patient had a history of stroke 1 year ago and is a known case of diabetes mellitus type 2 and systemic hypertension and is on medications. This case is extremely rare in Indian healthcare settings and can have an extensive impact on multiple organs.","PeriodicalId":50132,"journal":{"name":"Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46618418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
[Objective] ZEB2 is known to be participated in several cancers, yet there is no comprehensive analysis about its function in pan-cancer. This study aimed to investigate the role ZEB2 plays in pan-cancer. [Methods] The data was downloaded from the University of California Santa Cruz (UCSC) Xena and the Cancer Genome Atlas (TCGA). The mRNA expression status of ZEB2 was studied in the TCGA_GTEx samples, TCGA samples and paired samples in TCGA, respectively, and protein expression status was obtained from the University of Alabama at Birmingham Cancer data analysis Portal (UALCAN). Kaplan-Meier analysis was applied to 33 kinds of tumors in TCGA, then among the cancers that ZEB2 can affect prognosis, clinical correlation analysis and univariate and multivariate Cox regression analysis were performed. Furthermore, to confirm the prognostic value of ZEB2 in cancers, nomogram models were constructed on lung adenocarcinoma (LUAD) and stomach adenocarcinoma (STAD). The relationship between ZEB2 mRNA expression and immune cell infiltrates was determined by tumor immune estimation resource (TIMER2.0). Protein-protein interaction (PPI) networks were constructed by the STRING. Functional enrichment analysis was also performed using the “ClusterProfiler” package. [Results] ZEB2 was expressed in most tumors, either upregulated or downregulated, and correlated with clinical characteristics in a part of tumors. The expression level of ZEB2 was also found to impact the prognosis of tumors. Additionally, ZEB2 expression was significantly related to immune cells infiltration level in tumor microenvironment. [Conclusion] we propose that ZEB2 has the potential to be a prognostic biomarker and a promising target for cancer immunotherapy.
{"title":"A prognostic and immune infiltration analysis of ZEB2 in pan-cancer","authors":"Yihuang Zhan, Hui Ren, Chen Wang, Miao Yan, Zhiwei Yu, Mingzhe Li","doi":"10.6913/mrhk.050202","DOIUrl":"https://doi.org/10.6913/mrhk.050202","url":null,"abstract":"[Objective] ZEB2 is known to be participated in several cancers, yet there is no comprehensive analysis about its function in pan-cancer. This study aimed to investigate the role ZEB2 plays in pan-cancer. [Methods] The data was downloaded from the University of California Santa Cruz (UCSC) Xena and the Cancer Genome Atlas (TCGA). The mRNA expression status of ZEB2 was studied in the TCGA_GTEx samples, TCGA samples and paired samples in TCGA, respectively, and protein expression status was obtained from the University of Alabama at Birmingham Cancer data analysis Portal (UALCAN). Kaplan-Meier analysis was applied to 33 kinds of tumors in TCGA, then among the cancers that ZEB2 can affect prognosis, clinical correlation analysis and univariate and multivariate Cox regression analysis were performed. Furthermore, to confirm the prognostic value of ZEB2 in cancers, nomogram models were constructed on lung adenocarcinoma (LUAD) and stomach adenocarcinoma (STAD). The relationship between ZEB2 mRNA expression and immune cell infiltrates was determined by tumor immune estimation resource (TIMER2.0). Protein-protein interaction (PPI) networks were constructed by the STRING. Functional enrichment analysis was also performed using the “ClusterProfiler” package. [Results] ZEB2 was expressed in most tumors, either upregulated or downregulated, and correlated with clinical characteristics in a part of tumors. The expression level of ZEB2 was also found to impact the prognosis of tumors. Additionally, ZEB2 expression was significantly related to immune cells infiltration level in tumor microenvironment. [Conclusion] we propose that ZEB2 has the potential to be a prognostic biomarker and a promising target for cancer immunotherapy.","PeriodicalId":50132,"journal":{"name":"Journal of Medical Research","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88290434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ekono Michel Roger Guy, NgahaYaneu Junie, Elong Adolphe Félix, AminatouYababba Moussa Gambo, T. Charlotte
Introduction: The aim of this study was to describe the epidemiological-clinical profile of patients who underwent myomectomy by laparotomy in two first-level hospitals in the city of Douala, Cameroon. Methods: This was a retrospective descriptive study including the records of patients who underwent myomectomy by laparotomy from January 1, 2012 to December 31, 2020 at the General Hospital and the Gyneco-Obstetrics and Pediatric Hospital of Douala. Epidemiological, clinical and paraclinical data were collected. The results were analyzed using SPSS version 25 and Microsoft Excel 2016 software. Results: A total of 204 patients were enrolled. The mean age was 37.02±4.9 years. The nulliparous and the infertile respectively represented 68.1 and 66.7% of the participants. Abnormal bleeding (68.2%) was the most common reason for consultation. Anemia affected 72.1% of patients. Overweight and obesity were found respectively in 34.8 and 31.9% of patients. More than 7 out of 10 patients had a uterus larger than 16 weeks of amenorrhea. 4.40 cm. Interstitial and submucosal myomas involved respectively 82 and 53% of patients. Endometrial polyps were associated in 28.6% of explored cases. Conclusion: Myomectomy is performed in relatively elderly patients, consulting for abnormal bleeding, and associating infertility, overweight, and anemia. They present a large uterus, comprising voluminous myomas, mainly interstitial, but also submucosal, which can coexist with polyps, hence the interest of hysterosonography.
{"title":"Epidemio-clinical profile of patients who underwent myomectomy in two first-level hospitals in the city of Douala, Cameroon","authors":"Ekono Michel Roger Guy, NgahaYaneu Junie, Elong Adolphe Félix, AminatouYababba Moussa Gambo, T. Charlotte","doi":"10.31254/jmr.2023.9303","DOIUrl":"https://doi.org/10.31254/jmr.2023.9303","url":null,"abstract":"Introduction: The aim of this study was to describe the epidemiological-clinical profile of patients who underwent myomectomy by laparotomy in two first-level hospitals in the city of Douala, Cameroon. Methods: This was a retrospective descriptive study including the records of patients who underwent myomectomy by laparotomy from January 1, 2012 to December 31, 2020 at the General Hospital and the Gyneco-Obstetrics and Pediatric Hospital of Douala. Epidemiological, clinical and paraclinical data were collected. The results were analyzed using SPSS version 25 and Microsoft Excel 2016 software. Results: A total of 204 patients were enrolled. The mean age was 37.02±4.9 years. The nulliparous and the infertile respectively represented 68.1 and 66.7% of the participants. Abnormal bleeding (68.2%) was the most common reason for consultation. Anemia affected 72.1% of patients. Overweight and obesity were found respectively in 34.8 and 31.9% of patients. More than 7 out of 10 patients had a uterus larger than 16 weeks of amenorrhea. 4.40 cm. Interstitial and submucosal myomas involved respectively 82 and 53% of patients. Endometrial polyps were associated in 28.6% of explored cases. Conclusion: Myomectomy is performed in relatively elderly patients, consulting for abnormal bleeding, and associating infertility, overweight, and anemia. They present a large uterus, comprising voluminous myomas, mainly interstitial, but also submucosal, which can coexist with polyps, hence the interest of hysterosonography.","PeriodicalId":50132,"journal":{"name":"Journal of Medical Research","volume":"1217 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41279046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
[Objective] To explore the correlation between helicobacter pylori infection and several pathological features of gastritis, and provide evidence for pathological features analysis and diagnosis in helicobacter pylori associated gastritis. [Methods] We collected 180 patients with gastritis admitted to the Seventh Affiliated Hospital of Sun Yat-sen University from 2021 to 2022, and make a retrospective analysis of their status of H. pylori with PCR technology. Then we further detected the resistant results of clarithromycin and fluoroquinolone in H. pylori positive group. Chi-Squared Test were used to analyzed the relationship between helicobacter pylori status and pathological features of gastritis. [Results] Erosion or ulcers in the H. pylori-positive group were significantly higher than those in the H. pylori-negative group (P<0.05). Meanwhile, H. pylori-positive group were tended to have more severe activity or inflammation in the biopsy specimen. However, there was no significant difference in resistance to clarithromycin or fluoroquinolone in H. pylori-positive group with erosion, ulcers, or active inflammation. [Conclusion] Helicobacter pylori infection is correlated with gastritis pathological features such as erosion, ulcers, inflammation or activity, but the pathological features of H. pylori-positive patients could not predict the antibiotic resistance. The experiment of screening drug resistance still has important clinical significance.
{"title":"The analysis of pathological features of gastritis and Helicobacter pylori infection","authors":"Jianxian Huang, Chao‐Zhao Liang, Tianzhi Zhang","doi":"10.6913/mrhk.050201","DOIUrl":"https://doi.org/10.6913/mrhk.050201","url":null,"abstract":"[Objective] To explore the correlation between helicobacter pylori infection and several pathological features of gastritis, and provide evidence for pathological features analysis and diagnosis in helicobacter pylori associated gastritis. [Methods] We collected 180 patients with gastritis admitted to the Seventh Affiliated Hospital of Sun Yat-sen University from 2021 to 2022, and make a retrospective analysis of their status of H. pylori with PCR technology. Then we further detected the resistant results of clarithromycin and fluoroquinolone in H. pylori positive group. Chi-Squared Test were used to analyzed the relationship between helicobacter pylori status and pathological features of gastritis. [Results] Erosion or ulcers in the H. pylori-positive group were significantly higher than those in the H. pylori-negative group (P<0.05). Meanwhile, H. pylori-positive group were tended to have more severe activity or inflammation in the biopsy specimen. However, there was no significant difference in resistance to clarithromycin or fluoroquinolone in H. pylori-positive group with erosion, ulcers, or active inflammation. [Conclusion] Helicobacter pylori infection is correlated with gastritis pathological features such as erosion, ulcers, inflammation or activity, but the pathological features of H. pylori-positive patients could not predict the antibiotic resistance. The experiment of screening drug resistance still has important clinical significance.","PeriodicalId":50132,"journal":{"name":"Journal of Medical Research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75218412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irsa Shabbir, A. Qader, Z. Ahmad, H. Tariq, M. Davis, Sadia Rafique, Ali Zia
The aim of our study is to enhance the awareness about monkeypox virus among people so that its drastic effects can be overcome easily. An orthopox virus of the poxviridae family called the monkeypox virus (MPV) is currently causing worry on a global scale. It has two recognized viral clades and is indigenous to central and western Africa. The natural reservoirs are probably a variety of African rodents and primates. Direct contact with diseased animals, such as bites, scratches, and butchering, results in zoonotic transmission. Human to human transmission happens when two people come into close touch (for example, through skin-to-skin contact, sexual contact, or respiratory droplets). Human MPV illness often starts with a fever prodrome and lymphadenopathy,and then progresses to a diffuse maculopapular to vesiculopustular skin/mucosal lesion eruption. The febrile prodrome may be lacking in the current 2022 outbreak, which is mostly affecting males who have sex with men (MSM), and skin/mucosal lesions. The data in this study was collected from different data basis like google scholar, pubmed and medline etc by using various key words. However, the existing data is clearly indicating the drastic impact of MPV on human health and necessay steps must be taken to overcome it.
{"title":"Monleypox virus a rising concern in current age: A Mini Review on Epedmilogy, Clinical menifestations and Therapeutic interventions","authors":"Irsa Shabbir, A. Qader, Z. Ahmad, H. Tariq, M. Davis, Sadia Rafique, Ali Zia","doi":"10.31254/jmr.2023.9306","DOIUrl":"https://doi.org/10.31254/jmr.2023.9306","url":null,"abstract":"The aim of our study is to enhance the awareness about monkeypox virus among people so that its drastic effects can be overcome easily. An orthopox virus of the poxviridae family called the monkeypox virus (MPV) is currently causing worry on a global scale. It has two recognized viral clades and is indigenous to central and western Africa. The natural reservoirs are probably a variety of African rodents and primates. Direct contact with diseased animals, such as bites, scratches, and butchering, results in zoonotic transmission. Human to human transmission happens when two people come into close touch (for example, through skin-to-skin contact, sexual contact, or respiratory droplets). Human MPV illness often starts with a fever prodrome and lymphadenopathy,and then progresses to a diffuse maculopapular to vesiculopustular skin/mucosal lesion eruption. The febrile prodrome may be lacking in the current 2022 outbreak, which is mostly affecting males who have sex with men (MSM), and skin/mucosal lesions. The data in this study was collected from different data basis like google scholar, pubmed and medline etc by using various key words. However, the existing data is clearly indicating the drastic impact of MPV on human health and necessay steps must be taken to overcome it.","PeriodicalId":50132,"journal":{"name":"Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48023868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. M. Chia, Mohammad Hameed, A. A. Ugande, I. Obekpa
Background: Benign prostatic hypertrophy (BPH) is a major global public health problem and the most common benign prostatic disease in elderly men. Although rarely life-threatening, the increased morbidity significantly lowers men's quality of life, necessitating significant financial commitment to their annual health budgetary expenditure. We aim at determining the sonographic volumes of the prostate and post void residual urine in adult Nigerian men with BPH in Makurdi and to document any relevant relationship between the two values. Materials and methods: This was a 10-month prospective cross-sectional study conducted from June 2021 to April 2022. Transabdominal ultrasound (TAUS) was used to measure the prostate and post-void residual urine volumes of 78 men aged 40years and older, with normal levels of prostatic-specific antigen (PSA), who were referred to the ultrasound unit of radiology department of Benue State University Teaching Hospital (BSUTH), Makurdi. Collected data were analyzed using SPSS and Microsoft excel with P<0.05. Results: Postvoid residual urine volume (PVR) was observed to increase alongside the prostate volume (PV) from the 5th to the 6th decade of life; however, PVR began fluctuating from the 7th to the 8th decade, even though PV continued to increase steadily to its peak value at the 70-79 years of age, or the 8th decade. Overall, the mean prostate and post void residual urine volumes were 64.07±37.00ml and 76.44±110.34ml, respectively. A statistically significant (P=0.017) relationship existed between age and prostate volume but not between PV and PVR (P=0.128), where there was instead a weak, positive correlation. Although the bladder wall thickness (BWT) was greater than 5mm in more than half of the respondents 43(55.10%), there was no statistically significant (P=0.130) relationship between age and BWT. Conclusion: We established 64.07±37.00ml and 76.44±110.34ml respectively, as the overall mean sonographic volumes of the prostate and post void residual urine in adult Nigerian men with BPH in Makurdi. Despite the weak correlation between the two volumes, they can be used as a baseline for monitoring the progression of prostatic hyperplasia, bladder outlet obstruction and deciding on the best treatment option.
{"title":"Sonographic assessment of Prostate and Post void Residual Urine Volumes in patients with benign prostatic hypertrophy in Makurdi, North-central Nigeria","authors":"D. M. Chia, Mohammad Hameed, A. A. Ugande, I. Obekpa","doi":"10.31254/jmr.2023.9305","DOIUrl":"https://doi.org/10.31254/jmr.2023.9305","url":null,"abstract":"Background: Benign prostatic hypertrophy (BPH) is a major global public health problem and the most common benign prostatic disease in elderly men. Although rarely life-threatening, the increased morbidity significantly lowers men's quality of life, necessitating significant financial commitment to their annual health budgetary expenditure. We aim at determining the sonographic volumes of the prostate and post void residual urine in adult Nigerian men with BPH in Makurdi and to document any relevant relationship between the two values. Materials and methods: This was a 10-month prospective cross-sectional study conducted from June 2021 to April 2022. Transabdominal ultrasound (TAUS) was used to measure the prostate and post-void residual urine volumes of 78 men aged 40years and older, with normal levels of prostatic-specific antigen (PSA), who were referred to the ultrasound unit of radiology department of Benue State University Teaching Hospital (BSUTH), Makurdi. Collected data were analyzed using SPSS and Microsoft excel with P<0.05. Results: Postvoid residual urine volume (PVR) was observed to increase alongside the prostate volume (PV) from the 5th to the 6th decade of life; however, PVR began fluctuating from the 7th to the 8th decade, even though PV continued to increase steadily to its peak value at the 70-79 years of age, or the 8th decade. Overall, the mean prostate and post void residual urine volumes were 64.07±37.00ml and 76.44±110.34ml, respectively. A statistically significant (P=0.017) relationship existed between age and prostate volume but not between PV and PVR (P=0.128), where there was instead a weak, positive correlation. Although the bladder wall thickness (BWT) was greater than 5mm in more than half of the respondents 43(55.10%), there was no statistically significant (P=0.130) relationship between age and BWT. Conclusion: We established 64.07±37.00ml and 76.44±110.34ml respectively, as the overall mean sonographic volumes of the prostate and post void residual urine in adult Nigerian men with BPH in Makurdi. Despite the weak correlation between the two volumes, they can be used as a baseline for monitoring the progression of prostatic hyperplasia, bladder outlet obstruction and deciding on the best treatment option.","PeriodicalId":50132,"journal":{"name":"Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46773280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Dengue and malaria are infectious diseases transmitted by mosquitos mainly in tropical countries, including Indonesia, but there are only a few cases where both diseases are endemic in the same region. Malaria is difficult to diagnose in a dengue-endemic area due to the similar clinical symptoms. As a result, it can be misdiagnosed and affect treatment, resulting in a negative outcome. Case Presentation: This study presented a case of dengue and malaria coinfection in a 14-year-old overweight boy who was admitted to the hospital with fever, shivers, and a severe headache. Microscopic examination showed several form of Plasmodium falciparum’s trophozoite ring (Fig 1). Laboratories test showed a low thrombocyte level, 79.000/µL, hematocrit of 43.8%, serologic anti-dengue IgM was negative, and anti-dengue IgG was positive. Dengue therapy was administered in accordance with the World Health Organization's Dengue Diagnosis Guidelines, as well as the antimalarial drugs dihydroartemisinin-piperaquine and primaquine. There was no bleeding or shock during the five days of treatment, and no severe malaria complications were discovered. The patient was discharged with an improved general condition and normal hematological results. Conclusion: This paper aimed to emphasize the significance of early detection and appropriate management of dengue and malaria co-infection in dengue endemic areas in order to achieve a positive outcome and prevent complications.
{"title":"Dengue and Malaria Coinfection in An Overweight Child","authors":"Ninny Meutia Pelupessy, Lory Iswanto Latief, Ratna Dewi Artati, Destya Maulani","doi":"10.31254/jmr.2023.9204","DOIUrl":"https://doi.org/10.31254/jmr.2023.9204","url":null,"abstract":"Background: Dengue and malaria are infectious diseases transmitted by mosquitos mainly in tropical countries, including Indonesia, but there are only a few cases where both diseases are endemic in the same region. Malaria is difficult to diagnose in a dengue-endemic area due to the similar clinical symptoms. As a result, it can be misdiagnosed and affect treatment, resulting in a negative outcome. Case Presentation: This study presented a case of dengue and malaria coinfection in a 14-year-old overweight boy who was admitted to the hospital with fever, shivers, and a severe headache. Microscopic examination showed several form of Plasmodium falciparum’s trophozoite ring (Fig 1). Laboratories test showed a low thrombocyte level, 79.000/µL, hematocrit of 43.8%, serologic anti-dengue IgM was negative, and anti-dengue IgG was positive. Dengue therapy was administered in accordance with the World Health Organization's Dengue Diagnosis Guidelines, as well as the antimalarial drugs dihydroartemisinin-piperaquine and primaquine. There was no bleeding or shock during the five days of treatment, and no severe malaria complications were discovered. The patient was discharged with an improved general condition and normal hematological results. Conclusion: This paper aimed to emphasize the significance of early detection and appropriate management of dengue and malaria co-infection in dengue endemic areas in order to achieve a positive outcome and prevent complications.","PeriodicalId":50132,"journal":{"name":"Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41594949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Mousavi, Faezeh Heidari, Shahin Eghbali, Tahereh Fallah, Mahdie Hamidfar, S. Shahcheraghi
AIDS is an immune system deficiency disease. Still, the best way to control AIDS is prevention and awareness about this disease. The aim of the present study was to measure the level of knowledge of medical interns about AIDS. The present study was a cross-sectional study. A questionnaire was used in this research. The studied community included medical interns in 2019 and 2020. Finally, SPSS was used for analyzing. This study was conducted on 211 medical students. There was no significant difference in the knowledge level of the interns in terms of gender. The score of the questionnaire of the students who passed the infectious part was higher. In the current study was proved that the sex and marriage of the students was not effective on the awareness about AIDS.
{"title":"The level of awareness of medical students of the internship course of Shahid Sadoughi Hospital of Yazd about AIDS","authors":"S. Mousavi, Faezeh Heidari, Shahin Eghbali, Tahereh Fallah, Mahdie Hamidfar, S. Shahcheraghi","doi":"10.31254/jmr.2023.9206","DOIUrl":"https://doi.org/10.31254/jmr.2023.9206","url":null,"abstract":"AIDS is an immune system deficiency disease. Still, the best way to control AIDS is prevention and awareness about this disease. The aim of the present study was to measure the level of knowledge of medical interns about AIDS. The present study was a cross-sectional study. A questionnaire was used in this research. The studied community included medical interns in 2019 and 2020. Finally, SPSS was used for analyzing. This study was conducted on 211 medical students. There was no significant difference in the knowledge level of the interns in terms of gender. The score of the questionnaire of the students who passed the infectious part was higher. In the current study was proved that the sex and marriage of the students was not effective on the awareness about AIDS.","PeriodicalId":50132,"journal":{"name":"Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43067535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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