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Capacity planning in a decentralized autologous cell therapy manufacturing network for low-cost resilience. 去中心化自体细胞治疗制造网络的产能规划,实现低成本的弹性。
IF 2.7 3区 工程技术 Q2 Engineering Pub Date : 2023-01-01 Epub Date: 2022-11-05 DOI: 10.1007/s10696-022-09475-6
Junxuan Li, Chelsea C White

The goals for increased patient access and fast fulfillment have motivated considerable interest in autologous cell therapy manufacturing networks having multiple and geographically distributed manufacturing facilities. However, the cost of safety manufacturing capacity to mitigate supplier disruption risk-a significant risk in the emerging cell manufacturing industry-would be lower if manufacturing is centralized. In this paper, we analyze a decentralized network that has as its objective to minimize the cost of network resilience for mitigating supplier disruption by making use of the fact that bioreactors for autologous therapy manufacturing are small enough to be relocatable. We model this problem as a Markov decision process and develop efficient algorithms that are based on real-time demand data to minimize safety manufacturing capacity and determine how relocatable capacity should be distributed while satisfying resilience constraints. In case studies, based in part on data collected from a Chimeric antigen receptor T cell therapy manufacturing facility at the University of Pennsylvania, we compare decentralized network models with different heuristic algorithms. Results indicate that transshipment in a decentralized network can result in a significant reduction of required safety capacity, reducing the cost of network resilience.

增加患者访问和快速实现的目标激发了人们对具有多个地理分布的制造设施的自体细胞治疗制造网络的极大兴趣。然而,如果制造业集中化,降低供应商中断风险(新兴电池制造业的重大风险)的安全制造能力成本将更低。在本文中,我们分析了一个去中心化网络,其目标是通过利用用于自体治疗制造的生物反应器小到可以重新定位这一事实,最大限度地降低网络弹性成本,以缓解供应商中断。我们将这个问题建模为马尔可夫决策过程,并开发基于实时需求数据的高效算法,以最大限度地减少安全制造能力,并确定在满足弹性约束的情况下应如何分配可重新定位的能力。在案例研究中,部分基于从宾夕法尼亚大学嵌合抗原受体T细胞治疗制造厂收集的数据,我们将去中心化网络模型与不同的启发式算法进行了比较。结果表明,分散网络中的转运可以显著降低所需的安全容量,降低网络弹性的成本。
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引用次数: 1
Multi-objective-based differential evolution for balancing production cost, diversity and aggregated performance attributes in product family design 产品族设计中平衡生产成本、多样性和聚合性能属性的多目标差分进化
IF 2.7 3区 工程技术 Q2 Engineering Pub Date : 2022-12-26 DOI: 10.1007/s10696-022-09480-9
Ismail M. Ali, H. Turan, R. Chakrabortty, S. Elsawah
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引用次数: 1
Energy-efficient on/off control in serial production lines with Bernoulli machines 伯努利机器串联生产线的节能开关控制
IF 2.7 3区 工程技术 Q2 Engineering Pub Date : 2022-12-13 DOI: 10.1007/s10696-022-09481-8
Xiaohan Wang, Yaping Dai, Zhiyang Jia
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引用次数: 1
Integrated task sequence planning and assignment for human–robot collaborative assembly station 人机协同装配站的集成任务序列规划与分配
IF 2.7 3区 工程技术 Q2 Engineering Pub Date : 2022-12-10 DOI: 10.1007/s10696-022-09479-2
Yichen Wang, Junfeng Wang, Jindan Feng, Jinshan Liu, Xiaojun Liu
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引用次数: 2
Analytics and Optimization in Healthcare Management 医疗保健管理中的分析和优化
IF 2.7 3区 工程技术 Q2 Engineering Pub Date : 2022-12-09 DOI: 10.1007/s10696-022-09478-3
Vincent Augusto, N. Lahrichi, Ettore Lanzarone, Taesik Lee, Jie Song
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引用次数: 0
Correction to: Robust multi-period capacity, location, and access of rural cardiovascular services under uncertainty 修正为:不确定条件下农村心血管服务的多期能力、位置和可及性
IF 2.7 3区 工程技术 Q2 Engineering Pub Date : 2022-12-01 DOI: 10.1007/s10696-022-09451-0
Dominic Breuer, Khedidja Seridi, N. Lahrichi, Mohit Shukla, J. Benneyan
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引用次数: 0
Balancing and sequencing of mixed-model assembly line considering preventive maintenance scenarios: mathematical model and a migrating birds optimization algorithm 考虑预防性维修场景的混合装配线平衡与排序:数学模型与候鸟优化算法
IF 2.7 3区 工程技术 Q2 Engineering Pub Date : 2022-11-20 DOI: 10.1007/s10696-022-09477-4
Kai Meng, Qiuhua Tang, Zikai Zhang
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引用次数: 2
Decision modeling of the challenges to human–robot collaboration in industrial environment: a real world example of an emerging economy 工业环境中人机协作挑战的决策建模:一个新兴经济体的现实例子
IF 2.7 3区 工程技术 Q2 Engineering Pub Date : 2022-11-14 DOI: 10.1007/s10696-022-09474-7
Koppiahraj Karuppiah, Bathrinath Sankaranarayanan, S. Ali, R. Bhalaji
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引用次数: 1
Maritime inventory routing with transshipment: the case of Yamal LNG 具有转运的海运库存路线:亚马尔液化天然气案例
IF 2.7 3区 工程技术 Q2 Engineering Pub Date : 2022-11-05 DOI: 10.1007/s10696-022-09476-5
Mingyu Li, K. Fagerholt, P. Schütz
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引用次数: 2
Berth planning and real-time disruption recovery: a simulation study for a tidal port 泊位规划与实时中断恢复:潮汐港的模拟研究
IF 2.7 3区 工程技术 Q2 Engineering Pub Date : 2022-11-05 DOI: 10.1007/s10696-022-09473-8
Jaap-Jan van der Steeg, Menno Oudshoorn, N. Yorke-Smith
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引用次数: 3
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Flexible Services and Manufacturing Journal
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