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Venipuncture-related traumatic neuroma of the ulnar nerve on the dorsal of a hand: A case report. 手背尺神经静脉穿刺相关创伤性神经瘤:病例报告。
Pub Date : 2024-03-01 Epub Date: 2022-10-26 DOI: 10.1177/11297298221131395
Yidan Chen, Linfang Zhao, Chang Liu

A large number of venipunctures are placed on the dorsal of the hand, and it is suitable for the majority of patients with the advantage of few complications. Here, the ulnar nerve on the dorsal was injured during peripheral intravenous catheter insertion, and a painful traumatic neuroma was discovered a week later. Through oral medication and topical lidocaine medicated plaster, the patient's pain is greatly reduced, and allowed to engage in nearly all activities. Knowledge of this complication may help with its recognition and early treatment.

大量的静脉穿刺都是在手背上进行的,它适合大多数患者,并具有并发症少的优点。本例患者在插入外周静脉导管时损伤了手背的尺神经,一周后发现了疼痛的创伤性神经瘤。通过口服药物和局部利多卡因药物膏药,患者的疼痛大大减轻,几乎可以从事所有活动。了解这种并发症有助于识别和早期治疗。
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引用次数: 0
CFTR pharmacology. CFTR 药理学。
IF 8 Pub Date : 2017-01-01 Epub Date: 2016-10-04 DOI: 10.1007/s00018-016-2392-x
Olga Zegarra-Moran, Luis J V Galietta

CFTR protein is an ion channel regulated by cAMP-dependent phosphorylation and expressed in many types of epithelial cells. CFTR-mediated chloride and bicarbonate secretion play an important role in the respiratory and gastrointestinal systems. Pharmacological modulators of CFTR represent promising drugs for a variety of diseases. In particular, correctors and potentiators may restore the activity of CFTR in cystic fibrosis patients. Potentiators are also potentially useful to improve mucociliary clearance in patients with chronic obstructive pulmonary disease. On the other hand, CFTR inhibitors may be useful to block fluid and electrolyte loss in secretory diarrhea and slow down the progression of polycystic kidney disease.

CFTR 蛋白是一种受 cAMP 依赖性磷酸化调控的离子通道,在多种上皮细胞中均有表达。CFTR 介导的氯化物和碳酸氢盐分泌在呼吸系统和胃肠系统中发挥着重要作用。CFTR 的药理调节剂是治疗多种疾病的有效药物。特别是,纠正剂和增效剂可恢复囊性纤维化患者 CFTR 的活性。增效剂还可能用于改善慢性阻塞性肺病患者的粘液纤毛清除率。另一方面,CFTR 抑制剂可能有助于阻止分泌性腹泻患者的体液和电解质流失,并减缓多囊肾疾病的进展。
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引用次数: 0
Editorial For a Brighter Future: Solid State Lighting 社论为更光明的未来:固态照明
Pub Date : 2010-12-30 DOI: 10.1109/TCAPT.2010.2095051
M. Arik, A. Bar-Cohen, A. Pautsch
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引用次数: 1
Influence of Die Attach Layer on Thermal Performance of High Power Light Emitting Diodes 贴片层对大功率发光二极管热性能的影响
Pub Date : 2010-12-01 DOI: 10.1109/TCAPT.2009.2032097
B. Yan, J. You, N. Tran, Yongzhi He, F. Shi
In this paper, the influence of the die attach adhesive (DAA) layer on the thermal performance of high power light emitting diodes was first investigated by using finite element analysis, and some key results were verified by the experimental data. Effective thermal management of the studied light emitting diode package can be achieved by selecting a DAA material with a proper thermal conductivity and by manipulating the geometry parameters of the DAA layer, such as the DAA area, and the bond-line thickness. The significance of DAA thermal conductivity to heat dissipation was further demonstrated by an analysis of the bottleneck to heat transfer.
本文首先采用有限元分析方法研究了DAA层对大功率发光二极管热性能的影响,并通过实验数据验证了一些关键结果。通过选择具有适当热导率的DAA材料,并通过控制DAA层的几何参数(如DAA面积和键线厚度),可以实现对所研究的发光二极管封装的有效热管理。通过对传热瓶颈的分析,进一步证明了DAA导热系数对散热的重要性。
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引用次数: 35
Electrical Contact Resistance in Thin $({leq}{rm 0.5}~mu{rm m})$ Gold Plated Contacts: Effect of Gold Plating Thickness 薄触点电阻$({leq}{rm 0.5}~mu{rm m})$镀金触点:镀金厚度的影响
Pub Date : 2010-11-29 DOI: 10.1109/TCAPT.2010.2060340
P. Misra, J. Nagaraju
This paper describes the electrical contact resistance (ECR) measurements made on thin gold plated (gold plating of ≤ 0.5 μm with a Ni underlayer of ~2 μm) oxygen free high conductivity (OFHC) Cu contacts in vacuum environment. ECR in gold plated OFHC Cu contacts is found to be slightly higher than that in bare OFHC Cu contacts. Even though gold is a softer material than copper, the relatively high ECR values observed in gold plated contacts are mainly due to the higher hardness and electrical resistivity of the underlying Ni layer. It is well known that ECR is directly related to plating factor, which increases with increasing coating thickness when the electrical resistivity of coating material is more than that of substrate. Surprisingly, in the present case it is found that the ECR decreases with increasing gold layer thickness on OFHC Cu substrate (gold has higher electrical resistivity than OFHC Cu). It is analytically demonstrated from the topography and microhardness measurements results that this peculiar behavior is associated with thin gold platings, where the changes in surface roughness and microhardness with increasing layer thickness overshadow the effect of plating factor on ECR.
本文介绍了真空环境下无氧高导电性铜(OFHC)薄镀金(镀金≤0.5 μm,下镀Ni ~2 μm)触点的接触电阻(ECR)测量。发现镀金的OFHC铜触点的ECR略高于裸的OFHC铜触点。尽管金是一种比铜更软的材料,但在镀金触点中观察到的相对较高的ECR值主要是由于下面的Ni层的硬度和电阻率更高。众所周知,ECR与镀层因子直接相关,当镀层材料的电阻率大于衬底的电阻率时,ECR随镀层厚度的增加而增大。令人惊讶的是,在这种情况下,发现ECR随着OFHC Cu衬底上金层厚度的增加而降低(金的电阻率比OFHC Cu高)。从形貌和显微硬度测量结果分析表明,这种特殊行为与薄镀金层有关,其中表面粗糙度和显微硬度随层厚度的变化掩盖了镀因子对ECR的影响。
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引用次数: 15
Editorial - Science, Technology, and Industrial Policy 编辑-科学、技术和产业政策
Pub Date : 2010-11-29 DOI: 10.1109/TCAPT.2010.2078350
M. Pecht, L. Zuga
This editorial presents a case for the development of cohesive and non-partisan industrial and S&T policies that will foster engagement with other countries in the development of S&T. Examples of China and the U.S. are presented.
这篇社论提出了一个制定有凝聚力和无党派的工业和科技政策的案例,这些政策将促进与其他国家在科技发展方面的合作。以中国和美国为例。
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引用次数: 0
Glowing Connection Experiments With Alternating Currents Below 1${rm A}_{rm rms}$ 交流电流低于1${rm A}_{rm rms}$的发光连接实验
Pub Date : 2010-11-22 DOI: 10.1109/TCAPT.2010.2077737
J. Urbas
It was experimentally shown that a glowing connection can develop in an electrical switch at a terminal connection comprised of a connector that utilizes a spring action against a conductor to provide electrical contact in household electrical appliances where vibration exists, and when the connection is loose. This can happen at a current flow such as 0.6 Arms at 120-V. Further, the glow can provide sufficient heat to degrade plastic in contact with the terminal components. Violent arcing involving intense gasification can then develop on nearby plastic areas, sometimes accompanied by intensely glowing areas inside the plastic. Sometimes the intense glowing areas inside plastic develop without the violent arcing. The intense arcing or the glow inside plastic often develops into flaming, which can be of sufficient intensity and duration to ignite combustible materials near the connection.
实验表明,发光连接可以在电气开关的终端连接中发展,该终端连接由连接器组成,该连接器利用弹簧作用对抗导体,在存在振动的家用电器中提供电接触,并且当连接松动时。这可能发生在电流流,如0.6臂在120伏。此外,辉光可以提供足够的热量来降解与终端组件接触的塑料。剧烈的气化会在附近的塑料区域产生剧烈的电弧,有时会伴随着塑料内部的强烈发光区域。有时塑料内部的强烈发光区域在没有剧烈电弧的情况下发展。塑料内部的强烈电弧或发光经常发展成火焰,其强度和持续时间足以点燃连接处附近的可燃物。
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引用次数: 0
Thermal Resistance and Reliability of High-Power LED Packages Under WHTOL and Thermal Shock Tests 大功率LED封装在WHTOL和热冲击试验下的耐热性和可靠性
Pub Date : 2010-11-22 DOI: 10.1109/TCAPT.2010.2065805
M. Tsai, Chun-Hung Chen, W.L. Tsai
The light emitting diode (LED) packaging problems associated with high cost, high junction temperature, low luminous efficiency, and low reliability have to be resolved before the LED gaining more market acceptance. In this paper, chip-on-plate (CoP) LED packages with and without phosphors are evaluated in terms of thermal resistance and reliability under wet and high-temperature operation life (WHTOL) and thermal shock tests. The WHTOL test is with the condition of 85°C/85%RH and 350 mA of forward current for 1008 h, while thermal shock test is with 200 cycles at temperature ranging from -40°C to 125°C. The thermal behavior of the CoP packages was analyzed by 1-D thermal resistance circuit (1-D TRC) with and without spreading angle, 3-D TRC method, and 2-D axisymmetric finite element method. The feasibility of these analyses was evaluated and discussed in detail by comparing those results with experimental measurements. The reliability results indicated that all CoP packages with phosphors in the silicone encapsulant failed after 309 h in the WHTOL test, but all those without phosphors still survived after 1008 h. The failure modes were found to be the debonding of the aluminum wire from the chip or copper pad of the substrate. However, after the aluminum wire was replaced by gold wire, all the packages with and without phosphors passed after 1008 h. For these survival packages in the WHTOL test, their thermal resistances of junction-to-air and junction-to-aluminum substrate increased by about 12 and 9°C/W, respectively. Moreover, it was also found that there is a difference of 38°C/W in the junction-to-air thermal resistances for the packages between under natural and forced convections in the chamber during the WHTOL test. This might yield the different reliability data, unless the flow conditions in the test chamber are specified in this standard test. Furthermore, all the packages with and without phosphors could pass 200 cycles in thermal shock test, with minor changes in the thermal resistances. However, the degradation of luminous flux in the packages with phosphors was found to be greater than those without phosphors by 14% vs. 9%.
在发光二极管(LED)获得更多的市场接受之前,必须解决与高成本、高结温、低发光效率和低可靠性相关的封装问题。本文对带荧光粉和不带荧光粉的chip-on-plate (CoP) LED封装在湿、高温工作寿命(WHTOL)和热冲击测试下的耐热性和可靠性进行了评估。WHTOL测试在85°C/85%RH和350 mA正向电流条件下进行1008 h,热冲击测试在-40°C至125°C的温度范围内进行200次循环。采用一维热阻电路(1-D TRC)法、三维TRC法和二维轴对称有限元法对CoP封装的热行为进行了分析。通过与实验结果的比较,对这些分析的可行性进行了详细的评价和讨论。可靠性测试结果表明,含荧光粉的硅酮封装在309h后失效,而未含荧光粉的封装在1008h后仍然存活。失效模式为铝线与芯片或衬底铜衬垫的脱粘。而将铝线替换为金线后,1008 h后含荧光粉和不含荧光粉的封装全部通过。对于这些在WHTOL测试中的存活封装,其结对空气和结对铝基板的热阻分别提高了约12°C/W和9°C/W。此外,还发现在WHTOL测试中,在腔室中自然对流和强制对流之间,封装的结对空气热阻相差38°C/W。这可能会产生不同的可靠性数据,除非在本标准试验中规定了试验室内的流动条件。此外,所有带荧光粉和不带荧光粉的封装都可以通过200次热冲击测试,热阻变化很小。然而,光通量的衰减在有荧光粉的封装中比没有荧光粉的封装大14%比9%。
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引用次数: 23
Analysis of Thermal and Luminous Performance of MR-16 LED Lighting Module MR-16 LED照明模组的散热及发光性能分析
Pub Date : 2010-11-22 DOI: 10.1109/TCAPT.2010.2073469
W. Chi, T. Chou, Cheng-Nan Han, Shin-Yueh Yang, K. Chiang
Light emitting diode (LED) with a long lifetime, low power consumption, and low pollution has been successfully applied in many products. However, due to its low electro-optical conversion efficiency, high percentage of input power transformed to redundant heat, thus increasing the LED temperature. This phenomenon decreases the luminous flux, changing light color, and useful life span of LED. Therefore, thermal management becomes an important issue in high power LED. In this paper, the variation of luminous flux and light color for different LED lighting modules under long time operation has been measured and discussed. In addition, a detailed finite element model of LED lighting module, MR-16, with a corresponding input power and suitable boundary conditions is established by using the ANSYS finite element analysis program. Furthermore, to validate the simulation results, the current-voltage-temperature method for characterization of a diode is utilized to measure the junction temperature of LED chip indirectly and compare with simulation results. After the simulation is validated, various thermal performance assessments under the different design parameters of the LED package and lighting module are also investigated in this paper. The methodology and analysis results of this paper can provide a guideline for the LED lighting module such as MR-16 design in the future.
发光二极管(LED)具有长寿命、低功耗、低污染等优点,已成功应用于许多产品中。然而,由于其电光转换效率低,输入功率转化为冗余热量的比例很高,从而提高了LED的温度。这种现象降低了LED的光通量,改变了光色,降低了LED的使用寿命。因此,热管理成为大功率LED的一个重要问题。本文对不同LED照明模组在长时间工作下的光通量和光色变化进行了测量和讨论。此外,利用ANSYS有限元分析程序建立了具有相应输入功率和合适边界条件的LED照明模块MR-16的详细有限元模型。此外,为了验证仿真结果,采用电流-电压-温度表征二极管的方法间接测量LED芯片的结温,并与仿真结果进行比较。仿真验证后,本文还研究了LED封装和照明模块在不同设计参数下的各种热性能评估。本文的方法和分析结果可以为今后MR-16等LED照明模块的设计提供指导。
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引用次数: 43
Experimental/Numerical Analysis of Thermally Induced Warpage of Ultrathin Chip-on-Flex (UTCOF) Interconnects 超薄挠性芯片(UTCOF)互连热致翘曲的实验/数值分析
Pub Date : 2010-11-22 DOI: 10.1109/TCAPT.2010.2080273
Su-Tsai Lu, Wen-Hwa Chen
Future applications of flexible displays and wearable electronics will need 3-D stacked flexible interconnects. The interconnection of an ultrathin chip-on-flex (UTCOF) that can provide flexibility is one approach that meets this requirement. Therefore, thermally induced warpage of UTCOF interconnects using anisotropic conductive adhesive (ACA) is investigated. In this paper, the effects of the ACA joint material properties, bonding temperature, and chip thickness on warpage of ACA-bonded UTCOF interconnects are examined experimentally and numerically. Two film types of ACA materials, ACA-P and ACA-F, are assembled under different bonding temperatures to study the effects of bonding temperature on warpage via out-of-plane deformation measurements using a micro figure measurement instrument. Micro Au-bump and compliant-bump assemblies in 80-μm-pitch dummy test vehicles are evaluated. Moreover, ultrathin chips with 25-50 μm thickness were assembled onto polyimide flex substrates to study the effects of chip thickness on thermally induced warpage. The 85°C/85% relative humidity thermal humidity storage test (RH THST) was also conducted for 1000 h for the UTCOF assembled with the selected process parameters. The interfaces between the ultrathin silicon chip and substrate are inspected in cross-sectional scanning electron microscopy (SEM) images. To validate the results of the experiments, a rigorous 3-D finite element (FE) analysis model integrating both thermal and thermal-mechanical behaviors of the UTCOF is established and performed using the ANSYS program. Experimental and numerical results indicate that the warpage of the micro compliant-bump assembly is less than that of the micro Au bump. Furthermore, the averaged warpage of the ACA-P-bonded samples with the Au bump using a 50- μm-thick chip is around 50.3 μm at a bonding temperature of 160°C whereas that of the ACA-F-bonded samples is 64.4 μm at 190°C. Additionally, both thermal expansion mismatch and the thermal gradient between the ultrathin silicon chip and substrate strongly affect the thermal-mechanical behaviors of the UTCOF interconnects. As expected, warpage increases as thickness of an ultrathin silicon chip decreases. A strong correlation exists between FE analysis results and experimental results. The manufacturing technology for high-density and flexible UTCOF interconnects with ACA joints is thus established.
柔性显示器和可穿戴电子产品的未来应用将需要3-D堆叠柔性互连。能够提供灵活性的超薄柔性芯片(UTCOF)互连是满足这一要求的一种方法。因此,研究了各向异性导电胶(ACA)对UTCOF互连的热致翘曲。本文通过实验和数值研究了ACA连接材料性能、连接温度和芯片厚度对ACA连接UTCOF互连翘曲的影响。在不同的键合温度下组装ACA- p和ACA- f两种薄膜材料,利用微图测量仪测量面外变形,研究键合温度对翘曲的影响。对80 μm节距假人试验车上的微au碰撞和柔顺碰撞组件进行了评估。此外,将厚度为25 ~ 50 μm的超薄芯片组装在聚酰亚胺柔性衬底上,研究了芯片厚度对热致翘曲的影响。采用所选工艺参数组装的UTCOF,进行85°C/85%相对湿度的热湿储存试验(RH THST) 1000 h。采用扫描电镜(SEM)对超薄硅片与衬底之间的界面进行了研究。为了验证实验结果,建立了综合了UTCOF热行为和热力学行为的严格三维有限元分析模型,并利用ANSYS程序对其进行了分析。实验和数值结果表明,微柔碰撞组件的翘曲小于微金碰撞组件的翘曲。此外,在160℃的键合温度下,50 μm厚的aca - p键合样品的平均翘曲量约为50.3 μm,而在190℃的键合温度下,aca - f键合样品的平均翘曲量为64.4 μm。此外,超薄硅片与衬底之间的热膨胀失配和热梯度都强烈影响UTCOF互连的热力学行为。正如预期的那样,翘曲随着超薄硅片厚度的减小而增加。有限元分析结果与实验结果具有较强的相关性。由此建立了具有ACA接头的高密度柔性UTCOF互连的制造技术。
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引用次数: 11
期刊
IEEE Transactions on Components and Packaging Technologies
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