Brain and Cognition最新文献

Background

Despite accumulation of a substantial body of literature supporting the role of exercise on frontal lobe functioning, relatively less is understood of the interconnectivity of ventromedial prefrontal cortical (vmPFC) regions that underpin cardio-autonomic regulation predict cardiac chronotropic competence (CC) in response to sub-maximal exercise.

Methods

Eligibility of 161 adults (mean age = 48.6, SD = 18.3, 68% female) was based upon completion of resting state brain scan and sub-maximal bike test. Sliding window analysis of the resting state signal was conducted over 45-s windows, with 50% overlap, to assess how changes in photoplethysmography-derived HRV relate to vmPFC functional connectivity with the whole brain. CC was assessed based upon heart rate (HR) changes during submaximal exercise (HR change /HRmax (206–0.88 × age) – HRrest).

Results

During states of elevated HRV the vmPFC showed greater rsFC with an 83-voxel region of the hypothalamus (p < 0.001, uncorrected). Beta estimates of vmPFC connectivity extracted from a 6-mm sphere around this region emerged as the strongest predictor of CC (b = 0.283, p <.001) than age, BMI, and resting HRV F(8,144) = 6.30, p <.001.

Conclusion

Extensive glutamatergic innervation of the hypothalamus by the vmPFC allows for top-down control of the hypothalamus and its various autonomic efferents which facilitate chronotropic response during sub-maximal exercise.

Background

Working memory refers to our ability to temporarily store and process information, and it is crucial for efficient cognition and motor control. In the context of badminton matches, athletes need to make quick decisions and reactions in rapidly changing situations. Athletes with strong working memory capacity can better process this information and translate it into actual motor performance. Although previous research has demonstrated that exercise can improve brain function and structure, it remains unclear how the brain functions of athletes engaged in long-term professional training are specifically involved in performing working memory tasks.

Method

In this study, we assessed behavioral performance and cerebral oxygenation in the prefrontal lobe, using functional near-infrared spectroscopy, with 22 athletes and 30 non-athletes. Each participant was evaluated while performing 1-back, 2-back, and 3-back tasks. The area under the curve (AUC) of HbO (oxyhemoglobin) is used as an indicator of cortical brain oxygenation.

Results

The behavioral performance results indicated no difference between badminton athletes and non-athletes in the n-back task. We observed significantly different activation in channels of left FPA, right DLPFC, and left VLPFC when performing 3-back tasks. Brain activation indicated that long-term training in badminton caused a better performance in high-load working memory tasks.

Conclusions

Long-term professional training in badminton primarily activates the left frontal-parietal attention network (left FPA), right dorsolateral prefrontal cortex (right DLPFC), and left ventrolateral prefrontal cortex (left VLPFC) during working memory tasks.

Variance characterizes the structure of the environment. This statistical concept plays a critical role in evaluating the reliability of evidence for human decision-making. The present study examined the involvement of subcortical structures in the processing of visual variance. To this end, we used a stereoscope to sequentially present two circle arrays in a dichoptic or monocular fashion while participants compared the perceived variance of the two arrays. In Experiment 1, two arrays were presented monocularly to the same eye, dichopticly to different eyes, or binocularly to both eyes. The variance judgment was less accurate in different-eye condition than the other conditions. In Experiment 2, the first circle array was split into a large-variance and a small-variance set, with either the large-variance or small-variance set preceding the presentation of the second circle array in the same eye. The variance of the first array was judged larger when the second array was preceded by the large-variance set in the same eye, showing that the perception of variance was modulated by the visual variance processed in the same eye. Taken together, these findings provide evidence for monocular processing of visual variance, suggesting that subcortical structures capture the statistical structure of the visual world.

Evidence accumulates to show that semantic cognition requires, in addition to semantic representations, control processes that regulate the accessibility and use of semantic knowledge in a task- and time-appropriate fashion. Semantic control has been recently proposed to rely on a distributed network that includes the posterior temporal cortex. Along these lines, recent meta-analyses of neuroimaging data and studies with patients suffering from semantic aphasia have suggested that the left posterior middle temporal gyrus (pMTG) is critically involved whenever situational context must constrain semantic retrieval. In the present experiment, we used transcranial direct current stimulation over the left posterior temporal lobe in an attempt to interfere with semantic control while participants performed a DRM task, a procedure for inducing conceptually-based false recognition that is contingent on both activation and control processes. Paralleling findings with patients suffering from brain damage restricted to the temporoparietal cortex, anodal stimulation (relative to sham stimulation) resulted in increased false recognition but intact true recognition. These findings fit well with the idea that the left pMTG is a key component of a semantic control network, the alteration of which results in memory performance that is affected by the intrusion of contextually-inappropriate semantic information.

A primary objective of current human neuropsychological performance research is to define the physiological correlates of adaptive knowledge utilization, in order to support the enhanced execution of both simple and complex tasks. Within the present article, electroencephalography-based neurophysiological indices characterizing expert psychomotor performance, will be explored. As a means of characterizing fundamental processes underlying efficient psychometric performance, the neural efficiency model will be evaluated in terms of alpha-wave-based selective cortical processes. Cognitive and motor domains will initially be explored independently, which will act to encapsulate the task-related neuronal adaptive requirements for enhanced psychomotor performance associating with the neural efficiency model. Moderating variables impacting the practical application of such neuropsychological model, will also be investigated. As a result, the aim of this review is to provide insight into detectable task-related modulation involved in developed neurocognitive strategies which support heightened psychomotor performance, for the implementation within practical settings requiring a high degree of expert performance (such as sports or military operational settings).

Motivational deficits in patients recovering from stroke are common and can reduce active participation in rehabilitation and thereby impede functional recovery. We investigated whether stroke patients with clinically reduced drive, initiation, and endurance during functional rehabilitative training (n = 30) display systematic alterations in effort-based decision making compared to age, sex, and severity-matched stroke patients (n = 30) whose drive appeared unaffected. Notably, the two groups did not differ in self-reported ratings of apathy and depression. However, on an effort-based decision-making task, stroke patients with clinically apparent drive impairment showed intact willingness to accept effort for reward, but were more likely to fail to execute the required effort compared to patients without apparent drive impairments. In other words, the decision behavioural assessment revealed that stroke patients that displayed reduced drive, initiation, and endurance during inpatient neurorehabilitation failed to persist in goal-directed effort production, even over very short periods. These findings indicate that reduced drive during rehabilitative therapy in post-stroke patients is not due to a diminished motivation to invest physical effort, but instead is related to a reduced persistence with effortful behaviour.

Previous studies found that prolonged musical training can promote language processing, but few studies have examined whether and how musical training affects the processing of accentuation in spoken language. In this study, a vocabulary detection task was conducted, with Chinese single sentences as materials, to investigate how musicians and non-musicians process corrective accent and information accent in the sentence-middle and sentence-final positions. In the sentence-middle position, results of the cluster-based permutation t-tests showed significant differences in the 574–714 ms time window for the control group. In the sentence-final position, the cluster-based permutation t-tests revealed significant differences in the 612–810 ms time window for the music group and in the 616–812 ms time window for the control group. These significant positive effects were induced by the processing of information accent relative to that of corrective accent. These results suggest that both groups were able to distinguish corrective accent from information accent, but they processed the two accent types differently in the sentence-middle position. These findings show that musical training has a cross-domain effect on spoken language processing and that the accent position also affects its processing.

A depersonalization episode occurred unexpectedly during an electroencephalogram (EEG) recording for a study. Experience reports tracked the time course of this event and, in conjunction, with EEG data, were analyzed. The source activity across canonical frequency bands was analyzed across four periods ended by retrospective experience reports (depersonalization was reported in the 2nd period). Delta and theta decreases occurred across all time periods with no relation to reported events. Theta and alpha increases occurred in right secondary visual areas following depersonalization, which also coincided with surges in beta and gamma. The largest increases occurred in bilateral fronto-polar and medial prefrontal cortex, followed by inferior left lateral fronto-insula-temporal cortices and right secondary visual cortex. A high frequency functional network with a principal hub in left insula closely overlapped inferior left cortical gamma band-power increases. Bilateral frontal increases in gamma are consistent with studies of dissociation. We interpret gamma and later beta, alpha, and theta band increases as arising from the generation of visual priors, in the absence of precise visual signals, which constrain interoceptive and proprioceptive predictions to reestablish a stable sense of physiological-self. Beta showed local increases following the pattern of gamma but showed no changes in functional connectivity.

Background

The Penn Computerized Neurocognitive Battery is an efficient tool for assessing brain-behavior domains, and its efficiency was augmented via computerized adaptive testing (CAT). This battery requires validation in a separate sample to establish psychometric properties.

Methods

In a mixed community/clinical sample of N = 307 18-to-35-year-olds, we tested the relationships of the CAT tests with the full-form tests. We compared discriminability among recruitment groups (psychosis, mood, control) and examined how their scores relate to demographics. CAT-Full relationships were evaluated based on a minimum inter-test correlation of 0.70 or an inter-test correlation within at least 0.10 of the full-form correlation with a previous administration of the full battery. Differences in criterion relationships were tested via mixed models.

Results

Most tests (15/17) met the minimum criteria for replacing the full-form with the updated CAT version (mean r = 0.67; range = 0.53–0.80) when compared to relationships of the full-forms with previous administrations of the full-forms (mean r = 0.68; range = 0.50–0.85). Most (16/17) CAT-based relationships with diagnostics and other validity criteria were indistinguishable (interaction p > 0.05) from their full-form counterparts.

Conclusions

The updated CNB shows psychometric properties acceptable for research. The full-forms of some tests should be retained due to insufficient time savings to justify the loss in precision.

Studies with individuals with developmental dyslexia (DD) have documented impaired perception of words and faces, both of which are domains of visual expertise for human adults. In this study, we examined a possible mechanism that might be associated with the impaired acquisition of visual expertise for words and faces in DD, namely, the atypical engagement of the monocular visual pathway. Participants with DD and typical readers (TR) judged whether a pair of sequentially presented unfamiliar faces or nonwords were the same or different, and the pair of stimuli were displayed in an eye-specific fashion using a stereoscope. Based on evidence of greater reliance on subcortical structures early in development, we predicted differences between the groups in the engagement of lower (monocular) versus higher (binocular) regions of the visual pathways. Whereas the TR group showed a monocular advantage for both stimulus types, the DD participants evinced a monocular advantage for faces and words that was much greater than that measured in the TRs. These findings indicate that the DD individuals have enhanced subcortical engagement and that this might arise from the failure to fine-tune cortical correlates mediating the discrimination of homogeneous exemplars in domains of expertise.