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Analyzing the relationship between air temperature and respiratory morbidity in children and the elderly in Porto Alegre, Brazil, before and during the COVID-19 pandemic 分析2019冠状病毒病大流行之前和期间巴西阿雷格里港气温与儿童和老年人呼吸道疾病的关系
IF 3.2 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2023-07-12 DOI: 10.1007/s00484-023-02516-1
Eduardo L Krüger, Anderson Spohr Nedel, Ana Carla dos Santos Gomes, Paulo S. Lúcio

The aim of the study was to analyze the relationship between air temperature data against hospital admissions due to respiratory diseases of children (under five years of age) and the elderly (over 65) in subtropical Porto Alegre, Brazil, comparing outcomes for 3 sequential years, 2018–2020, pre- and post-COVID 19 pandemic. Meteorological and hospital admission (HA) data for Porto Alegre, marked by a Koeppen-Geiger’s Cfa climate type with well-defined seasons, were used in the analyses. HA was obtained for respiratory diseases (J00–99, according to the International Classification of Diseases, ICD-10) from the Brazilian DATASUS (Unified Health System database). We performed correlation analysis between variables (HA versus air temperature and heat stress) in order to identify existing relationships and lag effects (between meteorological condition and morbidity). Relative risk (RR) was also obtained for the two age groups during the three years. Results showed that the pandemic year disrupted observed patterns of association between analyzed variables, with either very low or non-existent correlations.

该研究的目的是分析巴西亚热带阿雷格里港的气温数据与因呼吸道疾病住院的儿童(5岁以下)和老年人(65岁以上)之间的关系,并比较2018-2020年、covid - 19大流行前后连续3年的结果。在分析中使用了阿雷格里港的气象和住院(HA)数据,这些数据以具有明确季节的koepen - geiger Cfa气候类型为标志。从巴西DATASUS(统一卫生系统数据库)获得呼吸系统疾病的HA(根据国际疾病分类,ICD-10) (J00-99)。我们进行了变量之间的相关分析(HA与气温和热应激),以确定存在的关系和滞后效应(气象条件和发病率之间)。相对危险度(RR)在三年内也得到了两个年龄组。结果表明,大流行年份破坏了所分析变量之间观察到的关联模式,相关性非常低或不存在相关性。
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引用次数: 0
Effect of hydrotherapy, balneotherapy, and spa therapy on blood pressure: a mini-review 水疗法、浴疗和温泉疗法对血压的影响:一个小回顾
IF 3.2 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2023-07-12 DOI: 10.1007/s00484-023-02512-5
Arezoo Moini Jazani, Hamidreza Nasimi Doost Azgomi, Alireza Nasimi Doost Azgomi, Ramin Nasimi Doost Azgomi

Abstract

Hypertension (high blood pressure) is one of the most common health conditions. When your blood pressure is high for a long term, it can cause health problems, such as heart disease. In addition to the main methods of treatment, there are various methods of adjuvant therapy, one of the most common of which is hydrotherapy. In this review study, we examined the effects of hydrotherapy, balneotherapy, and spa therapy on blood pressure. We searched the PubMed/MEDLINE, Web of Science, Scopus, and Science Direct databases until April 2022 using related keywords. In summary, the current study shows that different hydrotherapy methods may improve blood pressure. Hydrotherapy as one of the adjunctive therapy methods can be effective in lowering blood pressure. Blood circulation is smoothed by the warmth of the water. This improvement may be achieved by regulating heart rate, releasing hormones that control blood pressure, or regulating the activity of baroreceptors or chemoreceptors. In addition to using medications, hypertension patients also use non-pharmacological approaches in their care, including hydrotherapy, balneotherapy, and warm water foot soaks performed at home. Although several lines of evidence show the potential effects of hydrotherapy, balneotherapy, and spa therapy on blood pressure, many clinical trials are needed.

高血压(高血压)是最常见的健康状况之一。当你的血压长期偏高时,它会导致健康问题,比如心脏病。除了主要的治疗方法外,还有各种辅助治疗的方法,其中最常见的一种是水疗法。在本综述研究中,我们研究了水疗法、温泉疗法和水疗疗法对血压的影响。我们使用相关关键词检索了PubMed/MEDLINE、Web of Science、Scopus和Science Direct数据库,直到2022年4月。总之,目前的研究表明,不同的水疗方法可能会改善血压。水疗作为一种辅助治疗方法,可以有效降低血压。水的温暖使血液循环顺畅。这种改善可以通过调节心率,释放控制血压的激素,或调节压力感受器或化学感受器的活动来实现。除了使用药物治疗外,高血压患者还使用非药物治疗方法,包括水疗法、浴疗和在家进行温水足部浸泡。虽然有几条证据表明水疗法、浴疗和水疗疗法对血压有潜在影响,但还需要进行许多临床试验。
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引用次数: 1
The effect of ambient temperature and risk of cardiovascular disease hospitalization in China: a meta-analysis 环境温度对中国心血管疾病住院风险的影响:一项荟萃分析
IF 3.2 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2023-07-11 DOI: 10.1007/s00484-023-02509-0
Guangyu Zhai, Yiwen Tian, Yuqi Zhang, Wenjuan Zhou

The effect of ambient temperature on relative risk (RR) of cardiovascular disease (CVD) is different in China than in other countries due to the different geographical environment, climate the different inter- and intra-individual characteristics of the population within China. It is therefore important to integrate information to evaluate the impact of temperature on RR of CVD in China. We performed a meta-analysis to evaluate the effect of temperature on RR of CVD. The Web of Science, Google Scholar, and China National Knowledge Infrastructure databases were searched back to 2022 and nine studies were included in the study. The Cochran Q test and I2 statistics were used to assess heterogeneity, while Egger’s test was used to assess publication bias. The pooled estimated size of the relationship between ambient temperature and CVD hospitalization in the random effect model was 1.2044 (95%CI: 1.0610—1.3671) for the cold effect and 1.1982 (95%CI: 1.0166—1.4122) for the heat effect. The Egger’s test showed a potential publication bias for the cold effect, whereas there was no apparent publication bias for the heat effect. There is a significant effect of ambient temperature on RR of CVD for both the cold effect and heat effect. The effect of socioeconomic factors should be considered more thoroughly in future studies.

由于中国不同的地理环境、气候以及不同的人群个体间和个体内特征,环境温度对心血管疾病(CVD)相对危险度(RR)的影响与其他国家不同。因此,综合信息评价温度对中国CVD发病风险的影响具有重要意义。我们进行了一项荟萃分析来评估温度对心血管疾病RR的影响。该研究检索了Web of Science、Google Scholar和中国国家知识基础设施数据库,检索时间回溯至2022年,共纳入了9项研究。采用Cochran Q检验和I2统计量评估异质性,采用Egger检验评估发表偏倚。在随机效应模型中,环境温度与心血管疾病住院率之间关系的汇总估计大小为冷效应为1.2044 (95%CI: 1.0610-1.3671),热效应为1.1982 (95%CI: 1.0166-1.4122)。艾格检验显示冷效应有潜在的发表偏倚,而热效应没有明显的发表偏倚。环境温度对CVD的冷效应和热效应都有显著的影响。在今后的研究中,应更全面地考虑社会经济因素的影响。
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引用次数: 0
Gender inequalities in heat-related mortality in the Czech Republic 捷克共和国与高温有关的死亡率中的性别不平等
IF 3.2 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2023-07-10 DOI: 10.1007/s00484-023-02507-2
Chloé Vésier, Aleš Urban

It is acknowledged that climate change exacerbates social inequalities, and women have been reported as more vulnerable to heat than men in many studies in Europe, including the Czech Republic. This study aimed at investigating the associations between daily temperature and mortality in the Czech Republic in the light of a sex and gender perspective, taking into account other factors such as age and marital status. Daily mean temperature and individual mortality data recorded during the five warmest months of the year (from May to September) over the period 1995–2019 were used to fit a quasi-Poisson regression model, which included a distributed lag non-linear model (DLNM) to account for the delayed and non-linear effects of temperature on mortality. The heat-related mortality risks obtained in each population group were expressed in terms of risk at the 99th percentile of summer temperature relative to the minimum mortality temperature. Women were found generally more at risk to die because of heat than men, and the difference was larger among people over 85 years old. Risks among married people were lower than risks among single, divorced, and widowed people, while risks in divorced women were significantly higher than in divorced men. This is a novel finding which highlights the potential role of gender inequalities in heat-related mortality. Our study underlines the relevance of including a sex and gender dimension in the analysis of the impacts of heat on the population and advocates the development of gender-based adaptation policies to extreme heat.

众所周知,气候变化加剧了社会不平等,在欧洲包括捷克共和国的许多研究中,报告称女性比男性更容易受到高温的影响。这项研究的目的是调查捷克共和国的日常温度和死亡率之间的关系,从性别和性别的角度来看,考虑到其他因素,如年龄和婚姻状况。利用1995-2019年一年中最热的五个月(5月至9月)记录的日平均气温和个体死亡率数据,拟合了一个准泊松回归模型,该模型包括一个分布式滞后非线性模型(DLNM),以解释温度对死亡率的延迟和非线性影响。在每个人群组中获得的与热相关的死亡风险以夏季温度相对于最低死亡温度的第99个百分位数的风险表示。研究发现,女性通常比男性更容易因高温而死亡,在85岁以上的人群中,这一差异更大。已婚人群的风险低于单身、离婚和丧偶人群的风险,而离婚女性的风险明显高于离婚男性。这是一项新发现,强调了性别不平等在高温相关死亡率中的潜在作用。我们的研究强调了在分析高温对人口的影响时纳入性别维度的相关性,并倡导制定基于性别的极端高温适应政策。
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引用次数: 0
Application of microcontroller-based systems in human biometeorology studies: a bibliometric analysis 基于微控制器的系统在人类生物气象学研究中的应用:文献计量学分析
IF 3.2 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2023-07-10 DOI: 10.1007/s00484-023-02518-z
Eduardo Krüger, Walter Ihlenfeld, Solange Leder, Linccon Carvalho Lima

Urban development creates several inadvertent impacts related to urban climate and human biometeorology. Monitoring systems based on microcontrollers are slowly emerging as an alternative to conventional devices for monitoring outdoor thermal comfort (OTC), thus overcoming limitations imposed by the high costs of commercially available equipment. This review was conducted using the Scopus database, searching for articles and conference papers according to a pre-defined search string, which included the terms “microcontrollers” and “human thermal comfort” up to 2022. From a total sample of 113 articles, 52 papers met the desired criteria (written in English, published in peer-reviewed journals, and within the given time frame). Results show a growing, yet timid trend of published material on low-cost, open-source technologies for diverse applications in human biometeorology.

城市发展在不经意间对城市气候和人类生物气象产生了一些影响。基于微控制器的监测系统正逐渐成为监测室外热舒适(OTC)的传统设备的替代方案,从而克服了市售设备高成本所带来的限制。本综述使用Scopus数据库进行,根据预定义的搜索字符串搜索文章和会议论文,其中包括术语“微控制器”和“人体热舒适”,直到2022年。从113篇文章的总样本中,52篇论文达到了期望的标准(用英文写作,发表在同行评议的期刊上,并在给定的时间框架内)。研究结果表明,在人类生物气象学的各种应用中,关于低成本、开源技术的出版材料呈增长趋势,但趋势不大。
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引用次数: 0
Comparative assessment of growth performance of indigenous and cross-bred calves subjected to combined stressors (heat and nutritional) 本地犊牛和杂交犊牛在高温和营养双重应激条件下生长性能的比较
IF 3.2 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2023-07-07 DOI: 10.1007/s00484-023-02511-6
C. G. Shashank, R. G. Prashant, Parveen Kumar, Nitish A. Kulkarni, Manish Tiwari, S. Jayakumar, V. Sejian

This study evaluated the impact of combined stressors (heat and nutritional stresses) on the growth and adaptive capability of Sahiwal (SW) and Karan Fries (KF) calves during the summer season. Calves in each breed were randomly divided into four groups. In SW breed the groupings were as follows: SWC (n = 4; Sahiwal Control); SWHS (n = 4; Sahiwal Heat Stress); SWNS (n = 4; Sahiwal Nutritional Stress) and SWCS (n = 4; Sahiwal Combined Stresses). Likewise, in the KF breed, KFC (n = 4; Karan Fries Control); KFHS (n = 4; Karan Fries Heat Stress); KFNS (n = 4; Karan Fries Nutritional Stress), and KFCS (n = 4; Karan Fries Combined Stresses). Control (C) and Heat Stress (HS) calves were fed ad libitum while Nutritional Stress (NS) and Combined Stresses (CS) calves were fed restricted feed (50% of C calves of respective breed) to induce nutritional stress in both the breeds. SWHS, SWCS, KFHS, and KFCS were exposed to summer heat stress from 1000 to 1600 h. All growth and adaptation variables were recorded at fortnightly intervals. Respiration rate, pulse rate, and rectal temperature during the afternoon were significantly (P < 0.01) higher in the CS group in both breeds. Further, CS had significantly (P < 0.05) higher plasma growth hormone and cortisol levels. Insulin-like growth factor-1, Triiodothyronine, and Thyroxine levels significantly decreased (P < 0.05) in the CS group in both breeds. Interestingly, heat stress didn’t affect SWHS and KFHS bodyweight, however, a significant (P < 0.05) decrease in body weight of SWCS and KFCS was observed when compared with C. Hepatic mRNA expression of growth hormone, insulin-like growth factor-1, and growth hormone receptor significantly (P < 0.05) varied when compared between C and CS groups in both the breeds. The overall magnitude of stress was more pronounced in KF compared to the SW breed. This study concludes that when two stressors occur concurrently, they may have a greater influence on the adaptive capability of calves. Further, SW had better tolerance levels than KF, confirming the indigenous breed's superiority over cross-bred.

本研究评估了夏季热应激和营养应激对萨希瓦尔(SW)和卡兰弗里斯(KF)犊牛生长和适应能力的影响。每个品种的犊牛随机分为4组。在SW品种中分组如下:SWC (n = 4);。Sahiwal控制);SWHS (n = 4;Sahiwal热应力);SWNS (n = 4;Sahiwal营养应激)和SWCS (n = 4;Sahiwal组合应力)。同样,在KF品种中,KFC (n = 4;Karan Fries Control);KFHS (n = 4;Karan Fries热应激);KFNS (n = 4;Karan Fries营养应激)和KFCS (n = 4;Karan Fries综合压力)。对照(C)和热应激(HS)犊牛自由饲喂,营养应激(NS)犊牛和复合应激(CS)犊牛分别饲喂各自品种50%的限制性饲料,以诱导两个品种的营养应激。SWHS、SWCS、KFHS和KFCS在1000 ~ 1600 h经受夏季热胁迫,每隔两周记录所有生长和适应变量。2个品种的呼吸频率、脉搏频率和下午直肠温度均显著高于CS组(P < 0.01)。此外,CS组血浆生长激素和皮质醇水平显著升高(P < 0.05)。CS组胰岛素样生长因子-1、三碘甲状腺原氨酸和甲状腺素水平显著降低(P < 0.05)。有趣的是,热应激对SWHS和KFHS的体重没有影响,但与C组相比,SWCS和KFCS的体重显著降低(P < 0.05)。两个品种的肝脏生长激素、胰岛素样生长因子-1和生长激素受体mRNA表达在C组和CS组之间差异显著(P < 0.05)。与SW品种相比,KF品种的总体应激程度更为明显。本研究认为,当两种应激源同时存在时,它们可能对犊牛的适应能力产生更大的影响。此外,SW比KF具有更好的耐受水平,证实了本地品种比杂交品种的优势。
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引用次数: 1
The influence of virtual environment on thermal perception: physical reaction and subjective thermal perception on outdoor scenarios in virtual reality 虚拟环境对热感知的影响:虚拟现实户外场景的物理反应和主观热感知
IF 3.2 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2023-07-07 DOI: 10.1007/s00484-023-02495-3
Chunya Wu, Jinyuan Cui, Xiaowan Xu, Dexuan Song

Positive thermal perception can affect users’ climate-controlling behavior, indirectly reducing a building’s operational carbon emissions. Studies show that some visual elements, such as window sizes and light colors, can influence thermal perception. However, until recently there has been little interest in the interaction of thermal perception and outdoor visual scenarios or natural elements like water or trees, and little quantitative evidence has been found associating visual natural elements and thermal comfort. This experiment explores and quantifies the extent to which visual scenarios outdoors affect thermal perception. The experiment used a double-blind clinical trial. All tests were done in a stable laboratory environment to eliminate temperature changes, and scenarios were shown through a virtual reality (VR) headset. Forty-three participants were divided into three groups randomly, separately watched VR-outdoor scenarios with natural elements, VR-indoor scenarios, and a control scenario of the real laboratory, then finished a subjective questionnaire conducted to evaluate their thermal, environmental, and overall perceptions while their physical data (heart rate, blood pressure, pulse) was real-time recorded. Results show that visual scenarios could significantly influence thermal perception (Cohen’s d between groups > 0.8). Significant positive correlations were found between key thermal perception index, thermal comfort, and visual perception indexes including visual comfort, pleasantness, and relaxation (all PCCs ≤ 0.01). Outdoor scenarios, with better visual perception, rank higher average scores (M ± SD = 1.0 ± 0.7) in thermal comfort than indoor groups (average M ± SD = 0.3 ± 1.0) while the physical environment remains unchanged. This connection between thermal and environmental perception can be used in building design. By being visually exposed to pleasing outdoor environments, the positive thermal perception will increase, and thus reduce building energy consumption. Designing positive visual environments with outdoor natural elements is not only a requirement for health but also a feasible path toward a sustainable net-zero future.

积极的热感知可以影响用户的气候控制行为,间接减少建筑的运行碳排放。研究表明,一些视觉元素,如窗户大小和光线颜色,可以影响热感知。然而,直到最近,人们对热感知与室外视觉场景或水或树木等自然元素的相互作用几乎没有兴趣,并且很少发现将视觉自然元素与热舒适联系起来的定量证据。本实验探索并量化了户外视觉场景对热感知的影响程度。该实验采用双盲临床试验。所有测试均在稳定的实验室环境中进行,以消除温度变化,并通过虚拟现实(VR)耳机显示场景。43名参与者随机分为三组,分别观看带有自然元素的vr户外场景、vr室内场景和真实实验室的对照场景,然后完成一份主观问卷,评估他们的热、环境和整体感知,同时实时记录他们的身体数据(心率、血压、脉搏)。结果表明,视觉情景对热知觉有显著影响(组间Cohen’s d > 0.8)。主要热知觉指数、热舒适与视觉舒适、愉悦、放松等视觉知觉指数呈显著正相关(均≤0.01)。在物理环境不变的情况下,室外场景的热舒适平均得分(M±SD = 1.0±0.7)高于室内组(M±SD = 0.3±1.0)。这种热与环境感知之间的联系可以用于建筑设计。通过在视觉上暴露在令人愉悦的室外环境中,积极的热感知将增加,从而减少建筑能耗。设计具有户外自然元素的积极视觉环境不仅是健康的要求,也是通往可持续零净未来的可行途径。
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引用次数: 0
Effects of indoor temperature and its fluctuation on blood pressure and its variability 室内温度及其波动对血压及其变异性的影响
IF 3.2 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2023-07-06 DOI: 10.1007/s00484-023-02469-5
Ting Chen, Jian Ge, Xiaoyu Luo

Cardiovascular diseases (CVDs) are the number one health threat globally. Adverse indoor thermal environments are associated with excess mortality caused by CVDs in the cold season. While many studies have focused on the impact of indoor temperature on CVDs, none has considered the fluctuation of indoor temperature. To quantify the effect of indoor temperature on blood pressure and the effect of indoor temperature fluctuation on blood pressure variability (BPV), 172 middle-aged and elderly people in areas that experience both hot summers and cold winters in China completed a household survey regarding their characteristics and living habits. A hierarchical linear model (HLM) was used to analyze the impact of indoor temperature on home blood pressure. A multiple linear model was used to analyze the effect of indoor temperature fluctuation on day-to-day home blood pressure variability. The results showed that there was a significant negative correlation between morning temperature below 18 °C and blood pressure, especially systolic blood pressure (SBP). At the same time, morning temperature fluctuations have an independent influence on BPV, and a deviation of morning temperature fluctuation greater than 1.1 °C significantly increased BPV. Morning temperature and its fluctuation threshold for the rise of SBP and its variability of middle-aged and elderly people were clarified, which can provide a basis for the design, operation, and evaluation of residential thermal environmental health performance for the middle-aged and elderly population in this area, thereby reducing the cardiovascular health risk of the corresponding population.

心血管疾病(cvd)是全球头号健康威胁。不利的室内热环境与寒冷季节心血管疾病造成的超额死亡率有关。虽然许多研究都集中在室内温度对心血管疾病的影响上,但没有一个研究考虑室内温度的波动。为了量化室内温度对血压的影响以及室内温度波动对血压变异性(BPV)的影响,172名中国夏热冬冷地区的中老年人完成了一项关于他们的特征和生活习惯的家庭调查。采用层次线性模型(HLM)分析室内温度对家庭血压的影响。采用多元线性模型分析室内温度波动对日常家庭血压变异性的影响。结果显示,早晨温度低于18℃与血压,尤其是收缩压(SBP)呈显著负相关。同时,清晨温度波动对BPV有独立的影响,当清晨温度波动偏差大于1.1℃时,BPV显著升高。明确中老年人清晨温度及其波动阈值对收缩压上升的影响,为该地区中老年人住宅热环境健康性能的设计、运行和评价提供依据,从而降低相应人群的心血管健康风险。
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引用次数: 0
Exploring the potential role of health resort medicine in the management of breast cancer-related lymphedema: a viable alternative for innovative rehabilitation opportunities? 探索疗养医学在乳腺癌相关淋巴水肿管理中的潜在作用:创新康复机会的可行选择?
IF 3.2 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2023-07-06 DOI: 10.1007/s00484-023-02514-3
Maria Chiara Maccarone, Erika Venturini, Stefano Masiero

Lymphedema is a chronic and progressive disorder of the lymphatic system that impairs the return of lymphatic fluid. Breast cancer treatment can cause breast cancer-related lymphedema (BCRL), with axillary lymph node dissection and regional lymph node radiation being established risk factors. BCRL can cause severe morbidity, disability, and reduced quality of life. Early detection and treatment are essential to prevent the disease from progressing and causing complications. According to the International Society of Lymphology, complex decongestive therapy (CDT) is the most effective conservative treatment for lymphedema. Aquatic exercise is a safe and effective form of therapeutic CDT exercise that can improve joint range of motion, reduce pain, and positively impact limb volume. Additionally, health resort medicine and thermal mineral-rich waters may provide synergistic benefits for therapeutic exercise programs. Therefore, we believe that consideration should be given to whether the spa setting could represent a viable alternative for the rehabilitation of BCRL patients.

淋巴水肿是一种慢性进行性淋巴系统疾病,妨碍淋巴液的回流。乳腺癌治疗可引起乳腺癌相关淋巴水肿(BCRL),腋窝淋巴结清扫和局部淋巴结放疗是确定的危险因素。BCRL可导致严重的发病率、残疾和生活质量下降。早期发现和治疗对于防止疾病发展和引起并发症至关重要。根据国际淋巴学会,综合消血疗法(CDT)是治疗淋巴水肿最有效的保守疗法。水上运动是一种安全有效的治疗性CDT运动形式,可以改善关节活动范围,减轻疼痛,并对肢体体积产生积极影响。此外,疗养药物和热矿物质丰富的水可以为治疗性运动项目提供协同效益。因此,我们认为应该考虑水疗设置是否可以作为BCRL患者康复的可行选择。
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引用次数: 0
Ambient temperature modulates body weight changes in patients with advanced oncological diseases and anorexia cachexia syndrome 环境温度调节晚期肿瘤疾病和厌食性恶病质综合征患者的体重变化
IF 3.2 3区 地球科学 Q2 BIOPHYSICS Pub Date : 2023-07-04 DOI: 10.1007/s00484-023-02513-4
Paloma Encinas, Jose Luis Rodriguez-Arias, Luis Miguel Luengo Pérez, Daniel Cortizo, Emilio Gutierrez

Objective

To assess the impact of ambient temperature (AT) on the evolution of bodyweight in patients with heterogeneous types of cancer in advanced stages of the disease (stages III and IV) and anorexia- cachexia syndrome (ACS).

Methods

A prospective naturalistic multicenter study of patients undergoing oncological treatment at four hospitals during a three-year period (2017–2020) in the Autonomous Community of Extremadura in southwestern Spain with a continentalized Mediterranean climate of mild and relatively rainy winters, and particularly hot and sunny summers. Bodyweight changes were obtained from the medical records of 84 oncological patients (59 men and 25 women, age range 37–91 yrs). Mean monthly AT was used to examine the association of weight changes across cold and warm bimesters -BIMs (December and January, vs. July and August), Trimesters -TRIMs (July to September vs. December to February), and Semesters -SEMs (May to October vs. November to April). Weight changes between two consecutive weight measures were categorized as weight gain, weight loss, or no weight change. Differences across cold and warm seasons were analysed using parametric (ANOVA), and nonparametric statistics (Chi-square and binomial z tests). An alpha-rate of 0.05 was used for all analyses.

Results

A weight loss trend was observed during BIMs cold periods in comparison to warm ones (p 0.04). However, differences in average bodyweight were not significant. The negative impact of cold periods was more marked in men than in women, (p = 0.05; p = 0.03, for cold vs. warm BIMs and TRIMs, respectively). In contrast, significantly higher weight gain percentages were found in women during warm TRIMs and SEMs (p = 0.03, and p = 0.01, respectively). As for the number of patients dying during the study (N = 56; 39 men, 17 women), there were a significant interaction between temperature (cold/warm), and mean weight F (1, 499) = 6.06, p = 0.01, which revealed a pattern of weight loss in the cold semester as opposed to weight gain during the warm SEM months.

Conclusions

AT temperature modulated body weight changes in patients with advanced oncological disease and ACS. Two main limitations of the study were the absence of information on diets as a moderating factor of weight loss/gain, and the lack of the patients’ weight measurements closest to the date of diagnosis prior to admittance to the study. As for the practical implications, it remains to be seen whether an adjunctive heat supply will serve a buffering effect on weight loss during colder seasons for patients with advanced cancer and ACS.

目的探讨环境温度(AT)对异质性癌症晚期(III期和IV期)及厌食症-恶病质综合征(ACS)患者体重演变的影响。方法对西班牙西南部埃斯特雷马杜拉自治区的四家医院接受肿瘤治疗的患者进行为期三年(2017-2020年)的前瞻性自然多中心研究,该地区为大陆性地中海气候,冬季温和且相对多雨,夏季特别炎热且阳光充足。从84例肿瘤患者的医疗记录中获得体重变化(男性59例,女性25例,年龄37-91岁)。使用平均月平均AT来检查寒冷和温暖的两个月- bim(12月和1月,相对于7月和8月),三个月-TRIMs(7月至9月相对于12月至2月)和学期- sem(5月至10月相对于11月至4月)之间体重变化的关联。连续两次体重测量之间的体重变化被分类为体重增加、体重减少或体重没有变化。使用参数(ANOVA)和非参数统计(卡方检验和二项z检验)分析冷暖季节的差异。所有分析均采用α -率0.05。结果BIMs冷期体重下降趋势较暖期明显(p < 0.04)。然而,平均体重的差异并不显著。寒期的负面影响在男性中比女性更明显,(p = 0.05;p = 0.03,分别为冷bim与暖bim和TRIMs)。相比之下,在温暖的TRIMs和SEMs中,女性的体重增加百分比明显更高(p = 0.03和p = 0.01)。研究期间死亡患者人数(N = 56;39名男性,17名女性),温度(冷/暖)和平均体重之间存在显著的相互作用,F (1,499) = 6.06, p = 0.01,这揭示了在寒冷学期体重减轻的模式,而在温暖的SEM月份体重增加。结论体温可调节晚期肿瘤及ACS患者的体重变化。该研究的两个主要局限性是缺乏饮食作为体重减轻/增加的调节因素的信息,以及缺乏患者在进入研究之前最接近诊断日期的体重测量。至于实际意义,辅助供暖是否会对晚期癌症和ACS患者在寒冷季节的体重减轻起到缓冲作用,还有待观察。
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International Journal of Biometeorology
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