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Machine learning-enabled inverse design of bioinspired layered composite structures with maximum auxetic performance. 具有最大辅助性能的生物启发层状复合材料结构的机器学习逆设计。
Pub Date : 2025-11-24 DOI: 10.1038/s44172-025-00557-5
Yuze Li, Rui Li, Yin Fan, Zhouyu Zheng, Hui-Shen Shen, Xiuhua Chen, Minhua Wen, James Lin, Woong-Ryeol Yu, Yeqing Wang

Layered composite structures inspired by biological tissues can exhibit out-of-plane negative Poisson's ratio, but identifying layups that maximize auxetic performance is challenging in high-dimensional designs. Here, we introduce an inverse design framework that searches for laminate layups with minimum Poisson's ratio. The approach combines multi-start resampling with machine learning-guided clustering to map layup families across layer numbers. Analytical relations from laminate mechanics link ply angles to effective properties, and computer simulations with laboratory measurements validate the predicted minima. The analysis resolves three layup categories, explains how shear-strain mismatch across bonded plies drives through-thickness auxetic expansion, and shows that simple symmetry rules reduce the search space. The framework reproduces previously reported minima and uncovers layups that approach lower Poisson's ratios under practical constraints. These results provide a physics-grounded, data-efficient route to engineer layered composite structures with strong auxetic responses and offer concise design rules for impact mitigation, vibration control, and flexible structures.

受生物组织启发的层状复合材料结构可以表现出面外负泊松比,但在高维设计中,确定最大化消耗性能的层状复合材料结构是一项挑战。在这里,我们引入了一个逆设计框架,搜索具有最小泊松比的层叠层。该方法结合了多起点重采样和机器学习引导聚类来映射跨层数的分层族。从层压板力学、铺层角到有效性能的分析关系,以及实验室测量的计算机模拟验证了预测的最小值。分析解决了三种铺层类别,解释了剪切应变不匹配如何在粘合层之间驱动厚度的补充膨胀,并表明简单的对称规则减少了搜索空间。该框架再现了先前报道的最小值,并揭示了在实际约束下接近较低泊松比的铺层。这些结果为设计具有强辅助响应的层状复合材料结构提供了一种基于物理的、数据高效的途径,并为减少冲击、振动控制和柔性结构提供了简明的设计规则。
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引用次数: 0
Democratizing high-Q plasmonic optical fiber biosensing with low-resolution interrogation and Fourier demodulation. 利用低分辨率询问和傅立叶解调实现高q等离子体光纤生物传感的民主化。
Pub Date : 2025-11-24 DOI: 10.1038/s44172-025-00534-y
Hadrien Fasseaux, Médéric Loyez, Christophe Caucheteur

Gold-coated tilted fiber Bragg gratings have established themselves as powerful plasmonic biosensors, but their widespread deployment remains hindered by the need for costly, high-resolution interrogators and complex signal processing. Here, we demonstrate that tilted fiber Bragg gratings sensors can be effectively interrogated using a low-cost, coarsely resolved fiber Bragg grating interrogator with only 256 pixels spanning 45 nm, corresponding to a low resolution (~180 pm, 10 times coarser than standard interrogators). By applying a fast Fourier transform-based demodulation technique to the dense, comb-like cladding mode spectrum, we extract robust sensing information using only a narrow spectral window of a few tens of nanometers. This dramatically reduces hardware and computational requirements while preserving high sensitivity. We validate our approach in both refractometry and biosensing, targeting the clinically relevant biomarker Proteinase 3. Furthermore, we show that temperature cross-sensitivity can be compensated directly within this narrow spectral range by tracking a dedicated cladding mode resonance, eliminating the need to reference the Bragg mode. These advances pave the way for compact, cost-effective, and user-friendly plasmonic fiber sensor systems deployable in real-world biomedical environments.

金涂层倾斜光纤布拉格光栅已经成为强大的等离子体生物传感器,但其广泛部署仍然受到昂贵,高分辨率询问器和复杂信号处理的需求的阻碍。在这里,我们证明了倾斜光纤Bragg光栅传感器可以使用低成本、粗分辨率的光纤Bragg光栅询问器进行有效询问,该询问器只有256个像素,跨越45 nm,对应于低分辨率(~180 pm,比标准询问器粗10倍)。通过将基于快速傅立叶变换的解调技术应用于密集的梳状包层模式光谱,我们仅使用几十纳米的窄光谱窗口提取鲁棒传感信息。这大大减少了硬件和计算需求,同时保持高灵敏度。我们验证了我们的方法在折射和生物传感,针对临床相关的生物标志物蛋白酶3。此外,我们表明,温度交叉灵敏度可以通过跟踪专用包层模式共振在这个狭窄的光谱范围内直接补偿,从而消除了参考布拉格模式的需要。这些进步为在现实生物医学环境中部署的紧凑、经济、用户友好的等离子体光纤传感器系统铺平了道路。
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引用次数: 0
Photonic fully-connected hybrid beamforming using microring weight banks. 使用微环重量库的光子全连接混合波束形成。
Pub Date : 2025-11-24 DOI: 10.1038/s44172-025-00532-0
Mitchell Nichols, Hugh Morison, Armaghan Eshaghi, Bhavin Shastri, Lutz Lampe

Wireless communication at higher frequency bands has attracted research interest for fifth generation and beyond (5GB) wireless networks due to the large amount of unused bandwidth at these frequencies. However, there are substantial challenges associated with higher frequency bands due to the high path loss of the propagation environment and the high power consumption of the transceivers. Hybrid beamforming with massive multiple-input multiple-output (MIMO) has emerged as a solution to these problems by combining the performance and flexibility of digital beamforming with the energy efficiency of analog beamforming. Optical beamforming has recently been considered as an alternative to implement the analog component of a hybrid beamformer, which may offer improvements in size, weight and power consumption in comparison to conventional electronics. This paper proposes a new approach to implement an optical beamforming system based on photonic vector modulators using tunable photonic filters. Our experimental demonstration of the proposed optical beamformer shows that microring resonator (MRR)-based photonic vector modulators can be calibrated to achieve a root-mean-square (RMS) phase error of better than 2° and an amplitude error of 0.3 dB. Our findings identify a pathway to realize large-scale, fully-connected hybrid beamformers by leveraging compact and low loss photonic resonators.

由于在这些频率上有大量未使用的带宽,更高频段的无线通信已经引起了第五代及以上(5GB)无线网络的研究兴趣。然而,由于传播环境的高路径损耗和收发器的高功耗,存在与更高频段相关的实质性挑战。大规模多输入多输出(MIMO)混合波束形成将数字波束形成的性能和灵活性与模拟波束形成的能量效率相结合,成为解决这些问题的一种方法。光学波束形成最近被认为是实现混合波束形成器模拟组件的替代方案,与传统电子设备相比,它可以在尺寸、重量和功耗方面提供改进。本文提出了一种利用可调谐光子滤波器实现基于光子矢量调制器的光束形成系统的新方法。我们的实验证明,基于微环谐振器(MRR)的光子矢量调制器可以校准,实现均方根(RMS)相位误差优于2°,幅度误差为0.3 dB。我们的研究结果确定了通过利用紧凑和低损耗的光子谐振器实现大规模,全连接的混合波束形成的途径。
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引用次数: 0
Inverted perovskite solar modules with 99.3% geometrical fill factor via nanosecond single laser patterning. 通过纳秒单激光图件,具有99.3%几何填充因子的倒置钙钛矿太阳能组件。
Pub Date : 2025-11-21 DOI: 10.1038/s44172-025-00512-4
Andrés E R Soto, Vera C M Duarte, Adélio Mendes, Luísa Andrade

Perovskite solar cells (PSCs) hold promise for high-efficiency photovoltaic technology but face commercialization challenges due to scaling difficulties. A common approach for scaling PSCs involves creating perovskite solar modules (PSMs) with subcells connected in series, using P1, P2, and P3 laser scribing process to reduce interconnection losses. In this study, a standard nanosecond pulse UV laser was used to perform these scribes. Here we demonstrated that, by employing a single 45 µm laser line for each scribe, it can significantly reduce the dead area, resulting in exceptionally high geometric fill factors (GFFs). In inverted PSMs with active areas of 4.0 cm2 and 10.8 cm2, it was reached GFFs of 99.3% and 98.8%, respectively. To the best of author's knowledge, this work demonstrates the first successful use of a single nanosecond laser source for continuous P1-P2-P3 scribing, achieving a dead area as low as 0.7% in a 4 cm2 module.

钙钛矿太阳能电池(PSCs)有望成为高效光伏技术,但由于规模化困难,面临商业化挑战。扩展PSCs的一种常见方法是创建钙钛矿太阳能组件(psm),将子电池串联起来,使用P1, P2和P3激光刻划工艺来减少互连损失。在本研究中,使用标准的纳秒脉冲紫外激光器进行这些刻划。在这里,我们证明,通过为每个划线器使用单个45 μ m激光线,它可以显着减少死区,从而产生极高的几何填充因子(GFFs)。在活性面积为4.0 cm2和10.8 cm2的倒置psm中,gff分别达到99.3%和98.8%。据作者所知,这项工作首次成功地使用了单纳秒激光源进行连续P1-P2-P3刻划,在4 cm2模块中实现了低至0.7%的死区。
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引用次数: 0
Validation of an electroencephalography data assimilation-based computational approach for estimating cortical excitation-inhibition balance. 一种基于脑电图数据同化的估算皮层兴奋-抑制平衡的计算方法的验证。
Pub Date : 2025-11-20 DOI: 10.1038/s44172-025-00525-z
Hiroshi Yokoyama, Yoshihiro Noda, Masataka Wada, Mayuko Takano, Keiichi Kitajo

The excitation and inhibition (E/I) balance of neural circuits is a crucial index of neurophysiological homeostasis associated with healthy brain functioning. Although several cutting-edge methods exist to assess E/I balance in an intact brain, they have inherent limitations, such as difficulties in tracking changes in E/I balance over time. To address this, we introduced neural-mass-model-based tracking using a data assimilation (DA) approach. While we previously demonstrated that sleep-dependent E/I changes could be estimated from electroencephalography (EEG) data, the neurophysiological validity of this method had not been directly evaluated. In this study, we developed an enhanced DA-based method and compared its E/I estimates with the concurrent transcranial magnetic stimulation and electroencephalography (TMS-EEG) based measures. Our results revealed significant correlations between the DA-based estimates and TMS-EEG indices of E/I balance in the dorsolateral prefrontal cortex. These findings indicate that our computational approach provides neurophysiologically valid estimations of time-varying E/I balance.

神经回路的兴奋和抑制(E/I)平衡是与健康脑功能相关的神经生理稳态的重要指标。尽管有几种先进的方法可以评估完整大脑的E/I平衡,但它们都有固有的局限性,例如难以追踪E/I平衡随时间的变化。为了解决这个问题,我们使用数据同化(DA)方法引入了基于神经质量模型的跟踪。虽然我们之前证明睡眠依赖的E/I变化可以从脑电图(EEG)数据中估计出来,但这种方法的神经生理学有效性尚未得到直接评估。在这项研究中,我们开发了一种增强的基于da的方法,并将其E/I估计值与基于并发经颅磁刺激和脑电图(TMS-EEG)的测量结果进行了比较。我们的研究结果显示,基于da的估计值与TMS-EEG的背外侧前额皮质E/I平衡指数之间存在显著相关性。这些发现表明,我们的计算方法提供了时变E/I平衡的神经生理学有效估计。
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引用次数: 0
Pillar arrays as tunable interfacial barriers for microphysiological systems. 柱阵列作为微生理系统的可调界面屏障。
Pub Date : 2025-11-20 DOI: 10.1038/s44172-025-00527-x
Ishan Goswami, Yongdeok Kim, Gabriel Neiman, Brian Siemons, Jazmin I Velazquez, Kerem Yazgan, Tammy Ng, Sudipta Ashe, Kevin E Healy

We report on the design and fabrication of a circular pillar array as an interfacial barrier for microfluidic microphysiological systems (MPS). Traditional barrier interfaces, such as porous membranes and microchannel arrays, present limitations due to inconsistent pore size, complex fabrication and device assembly, and a lack of tunability using a scalable design. Our pillar array overcomes these limitations by providing precise control over pore size, porosity, and hydraulic resistance through simple modifications of pillar dimensions. Serving as an interface between microfluidic compartments, it facilitates cell aggregation for tissue formation and acts as a tunable diffusion barrier that mimics diffusion in vivo. We demonstrate the utility of barrier design to engineer physiologically relevant cardiac microtissues and a heterotypic model with vasculature within the device. The tunable properties offer significant potential for drug screening/testing and disease modeling, enabling comparisons of drug permeability and cell migration in MPS tissue with or without vasculature.

我们报道了一种圆形柱阵列作为微流控微生理系统(MPS)的界面屏障的设计和制造。传统的屏障界面,如多孔膜和微通道阵列,由于孔径不一致,制造和器件组装复杂,以及使用可扩展设计缺乏可调性而存在局限性。通过简单修改柱的尺寸,我们的柱阵列可以精确控制孔径、孔隙度和水力阻力,从而克服了这些限制。作为微流体隔室之间的界面,它促进细胞聚集以形成组织,并作为可调节的扩散屏障,模拟体内扩散。我们展示了屏障设计的实用性,以工程生理相关的心脏微组织和异型模型的血管在设备内。这种可调特性为药物筛选/测试和疾病建模提供了巨大的潜力,可以比较有或没有脉管系统的MPS组织中的药物渗透性和细胞迁移。
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引用次数: 0
Computational modelling of hollow fibre haemodialysers: current status and future directions. 中空纤维血液透析器的计算模型:现状与未来方向。
Pub Date : 2025-11-20 DOI: 10.1038/s44172-025-00526-y
Ruhit Sinha, Anne E Staples

Current in silico dialyser models remain accurate only under narrowly constrained conditions. Advances in computing power and increasing levels of interdisciplinary collaboration, however, now set the stage for more robust computational haemodialyser models. In this review, we survey existing modelling approaches-long used to guide haemodialyser design and clinical nephrology practice-identify key unresolved challenges, and propose computational strategies poised to accelerate the development of dialyser technologies that better meet the needs of kidney failure patients.

目前的硅透析器模型仅在狭窄的约束条件下保持准确。然而,计算能力的进步和跨学科合作水平的提高,现在为更强大的计算血液透析模型奠定了基础。在这篇综述中,我们调查了现有的建模方法——长期用于指导血液透析设计和临床肾脏病实践——确定了关键的未解决的挑战,并提出了计算策略,以加速透析技术的发展,更好地满足肾衰竭患者的需求。
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引用次数: 0
Degrees of uncertainty: conformal deep learning for non-invasive core body temperature prediction in extreme environments. 不确定度:适形深度学习在极端环境下的无创核心体温预测。
Pub Date : 2025-11-20 DOI: 10.1038/s44172-025-00548-6
Joel Strickland, Marco Ghisoni, Hannah Marshall, Thomas Whitehead, Bogdan Nenchev, Ben Pellegrini, Charles Phillips, Karl Tassenberg, Sarah Davey, Sandra Dorman, Joseph Sol, David Ferguson, Gareth Conduit

Accurate estimation of core body temperature (CBT) is essential for physiological monitoring, yet current non-invasive methods lack statistically calibrated uncertainty estimates required for safety-critical use. Here we introduce a conformal deep learning framework for real-time, non-invasive CBT prediction with calibrated uncertainty, demonstrated in high-risk heat-stress environments. Developed from over 140,000 physiological measurements across six operational domains, the model achieves a test error of 0.29 °C, outperforming the widely used ECTemp™ algorithm with a 12-fold improvement in calibrated probabilistic accuracy and statistically valid prediction intervals. Designed for integration with wearable devices, the system uses accessible physiological, demographic, and environmental inputs to support practical, confidence-informed monitoring. A customizable alert engine enables proactive safety interventions based on user-defined thresholds and model confidence. By combining deep learning with conformal prediction, this approach establishes a generalizable foundation for trustworthy, non-invasive physiological monitoring, demonstrated here for CBT under heat stress but applicable to broader safety-critical settings.

准确估计核心体温(CBT)对于生理监测至关重要,但目前的非侵入性方法缺乏安全关键应用所需的统计校准不确定性估计。在这里,我们引入了一个适形深度学习框架,用于实时、无创的CBT预测,具有校准的不确定性,在高风险热应激环境中得到了验证。该模型从六个操作域的140,000多个生理测量数据中开发而来,测试误差为0.29°C,优于广泛使用的ECTemp™算法,校准概率精度和统计有效预测区间提高了12倍。该系统设计用于与可穿戴设备集成,使用可访问的生理、人口统计和环境输入来支持实用的、有信心的监测。可定制的警报引擎支持基于用户定义的阈值和模型置信度的主动安全干预。通过将深度学习与适形预测相结合,这种方法为可信赖的、无创的生理监测建立了一个可推广的基础,这里展示了热应激下的CBT,但适用于更广泛的安全关键环境。
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引用次数: 0
Huge transverse Maxwell stress in ferroelectric fluids and prototyping of new ferroelectric motors. 铁电流体中的巨大横向麦克斯韦应力及新型铁电马达的原型设计。
Pub Date : 2025-11-19 DOI: 10.1038/s44172-025-00530-2
Tatsuhiro Tsukamoto, Suzushi Nishimura

Electrostatic actuators typically rely on Maxwell stress, whereas the use of transverse electrostatic force (TEF) has been overlooked because of its weakness. The discovery of polar nematic liquid crystals in 2017 changed this, enabling lower operating voltages and high output power. We here explore TEF in a ferroelectric fluid and demonstrate a ferroelectric motor based on a new driving principle. Using ferroelectric nematic liquid crystals, we show that TEF can elevate the fluid between electrodes with a gap of 2.5 mm up to more than 80 mm at only 28 V mm-1, corresponding to a stress greater than 1000 N m-2. Polarization analysis also revealed a continuous paraelectric-to-ferroelectric transition. Unlike electromagnetic motors, ferroelectric motors require no metal rotors or magnets, resulting in a lower weight and simplified device structure and eliminating the need for rare-earth materials. These results suggest that ferroelectric fluids can enhance electrostatic actuator performance and practicability.

静电致动器通常依赖于麦克斯韦应力,而横向静电力(TEF)的使用由于其弱点而被忽视。2017年极性向列液晶的发现改变了这一点,实现了更低的工作电压和高输出功率。我们在此探索铁电流体中的TEF,并展示一种基于新驱动原理的铁电马达。利用铁电向列液晶,我们发现TEF可以在28 V mm-1的条件下将电极间隙为2.5 mm的流体提升到80 mm以上,对应于大于1000 N m-2的应力。极化分析也揭示了一个连续的准电到铁电的转变。与电磁电机不同,铁电电机不需要金属转子或磁铁,因此重量更轻,简化了设备结构,并且消除了对稀土材料的需求。这些结果表明,铁电流体可以提高静电执行器的性能和实用性。
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引用次数: 0
Dynamic hovering for uncrewed underwater vehicles via an error-separation-based cooperative strategy. 基于误差分离的无人潜航器动态悬停协同策略。
Pub Date : 2025-11-18 DOI: 10.1038/s44172-025-00528-w
Xiaoli Luan, Shenhan Yu, Haiying Wan, Fei Liu

Uncrewed underwater vehicles(UUVs) play an indispensable role in ocean resource efficiency utilization due to their security and cost-effectiveness. However, the significant uncertainties, time-varying disturbances, and unstructured subsea environments pose challenges for UUVs in achieving precise and efficient marine missions. To address these challenges, this study introduces a novel cooperative control framework for UUVs. The proposed framework minimizes the high control efforts of sliding mode control while preserving robustness, enabling efficiency and precision for long-duration dynamic hovering missions of UUVs. Specifically, a key innovation is the development of a deviation separation strategy, which, for the first time, decouples hovering deviations into task-specific and anti-disturbance components using an influence function. This enables real-time disturbance estimation without prior knowledge enabling adaptive disturbance compensation. By cooperating between LQR and SMC, the proposed method avoids the performance conflicts commonly observed in single-controller schemes. This structure improves compensation accuracy, robustness to disturbances, and energy efficiency across various operating conditions. The results demonstrate that the proposed cooperative control strategy effectively counters current perturbations by leveraging the real-time insights from the error segregation, while concurrently executing high-precision hovering tasks with low control costs. This work advances UUVs control, offering a versatile solution for complex underwater tasks.

无人潜航器以其安全性和经济性在海洋资源高效利用中发挥着不可或缺的作用。然而,巨大的不确定性、时变干扰和非结构化海底环境对uuv实现精确、高效的海上任务构成了挑战。为了解决这些挑战,本研究引入了一种新的uuv协同控制框架。该框架最大限度地减少了滑模控制的高控制工作量,同时保持了鲁棒性,使无人潜航器长时间动态悬停任务的效率和精度得以实现。具体来说,一个关键的创新是偏差分离策略的发展,该策略首次使用影响函数将悬停偏差解耦为特定任务和抗干扰组件。这使得实时干扰估计没有先验知识,使自适应干扰补偿。该方法通过LQR和SMC的协作,避免了单控制器方案中常见的性能冲突。这种结构提高了补偿精度,对干扰的鲁棒性,以及在各种操作条件下的能源效率。结果表明,所提出的协同控制策略利用误差分离的实时洞察,有效地对抗当前扰动,同时以较低的控制成本执行高精度悬停任务。这项工作推进了uuv控制,为复杂的水下任务提供了一个通用的解决方案。
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引用次数: 0
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Communications engineering
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