Pub Date : 2024-11-26DOI: 10.1038/s41422-024-01056-6
Cell Research Editorial Team
{"title":"Sanofi-Cell Research outstanding paper award of 2023","authors":"Cell Research Editorial Team","doi":"10.1038/s41422-024-01056-6","DOIUrl":"10.1038/s41422-024-01056-6","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"34 12","pages":"817-817"},"PeriodicalIF":28.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41422-024-01056-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-26DOI: 10.1038/s41422-024-01047-7
Wen Zhang, David Artis
{"title":"Stressing out the intestinal microbiota via a brain-neuroglandular circuit.","authors":"Wen Zhang, David Artis","doi":"10.1038/s41422-024-01047-7","DOIUrl":"https://doi.org/10.1038/s41422-024-01047-7","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1038/s41422-024-01051-x
Yingying Zhang, Jiahuai Han
The beneficial role of gasdermin activation and pyroptosis induction in antitumor immunity has been implicated by several studies; however, the question of how to specifically and efficiently activate cancer cell death while minimizing toxicity to host cells remains unsolved. In a recent paper published inCell, Wu and Lieberman groups identified a GSDMD agonist that can induce low-level pyroptosis in cancer cells but not in host cells, offering potential applications in cancer vaccine development and therapy in combination with checkpoint blockade.
{"title":"A GSDMD agonist boosts specific antitumor immunity","authors":"Yingying Zhang, Jiahuai Han","doi":"10.1038/s41422-024-01051-x","DOIUrl":"https://doi.org/10.1038/s41422-024-01051-x","url":null,"abstract":"<p><b>The beneficial role of gasdermin activation and pyroptosis induction in antitumor immunity has been implicated by several studies; however, the question of how to specifically and efficiently activate cancer cell death while minimizing toxicity to host cells remains unsolved. In a recent paper published in</b> <b><i>Cell</i></b><b>, Wu and Lieberman groups identified a GSDMD agonist that can induce low-level pyroptosis in cancer cells but not in host cells, offering potential applications in cancer vaccine development and therapy in combination with checkpoint blockade</b>.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"41 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-31DOI: 10.1038/s41422-024-01045-9
Korbinian Traeuble, Matthias Heinig
{"title":"A cross-species foundation model for single cells","authors":"Korbinian Traeuble, Matthias Heinig","doi":"10.1038/s41422-024-01045-9","DOIUrl":"10.1038/s41422-024-01045-9","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"34 12","pages":"818-819"},"PeriodicalIF":28.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41422-024-01045-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-17DOI: 10.1038/s41422-024-01027-x
Ting Zhao, Xueying Guan, Yan Hu, Ziqian Zhang, Han Yang, Xiaowen Shi, Jin Han, Huan Mei, Luyao Wang, Lei Shao, Hongyu Wu, Qianqian Chen, Yongyan Zhao, Jiaying Pan, Yupeng Hao, Zeyu Dong, Xuan Long, Qian Deng, Shengjun Zhao, Mengke Zhang, Yumeng Zhu, Xiaowei Ma, Zequan Chen, Yayuan Deng, Zhanfeng Si, Xin Li, Tianzhen Zhang, Fei Gu, Xiaofeng Gu, Lei Fang
DNA methylation plays multiple regulatory roles in crop development. However, the relationships of methylation polymorphisms with genetic polymorphisms, gene expression, and phenotypic variation in natural crop populations remain largely unknown. Here, we surveyed high-quality methylomes, transcriptomes, and genomes obtained from the 20-days-post-anthesis (DPA) cotton fibers of 207 accessions and extended the classical framework of population genetics to epigenetics. Over 287 million single methylation polymorphisms (SMPs) were identified, 100 times more than the number of single nucleotide polymorphisms (SNPs). These SMPs were significantly enriched in intragenic regions while depleted in transposable elements. Association analysis further identified a total of 5,426,782 cis-methylation quantitative trait loci (cis-meQTLs), 5078 cis-expression quantitative trait methylation (cis-eQTMs), and 9157 expression quantitative trait loci (eQTLs). Notably, 36.39% of cis-eQTM genes were not associated with genetic variation, indicating that a large number of SMPs associated with gene expression variation are independent of SNPs. In addition, out of the 1715 epigenetic loci associated with yield and fiber quality traits, only 36 (2.10%) were shared with genome-wide association study (GWAS) loci. The construction of multi-omics regulatory networks revealed 43 cis-eQTM genes potentially involved in fiber development, which cannot be identified by GWAS alone. Among these genes, the role of one encoding CBL-interacting protein kinase 10 in fiber length regulation was successfully validated through gene editing. Taken together, our findings prove that DNA methylation data can serve as an additional resource for breeding purposes and can offer opportunities to enhance and expedite the crop improvement process.
{"title":"Population-wide DNA methylation polymorphisms at single-nucleotide resolution in 207 cotton accessions reveal epigenomic contributions to complex traits","authors":"Ting Zhao, Xueying Guan, Yan Hu, Ziqian Zhang, Han Yang, Xiaowen Shi, Jin Han, Huan Mei, Luyao Wang, Lei Shao, Hongyu Wu, Qianqian Chen, Yongyan Zhao, Jiaying Pan, Yupeng Hao, Zeyu Dong, Xuan Long, Qian Deng, Shengjun Zhao, Mengke Zhang, Yumeng Zhu, Xiaowei Ma, Zequan Chen, Yayuan Deng, Zhanfeng Si, Xin Li, Tianzhen Zhang, Fei Gu, Xiaofeng Gu, Lei Fang","doi":"10.1038/s41422-024-01027-x","DOIUrl":"10.1038/s41422-024-01027-x","url":null,"abstract":"DNA methylation plays multiple regulatory roles in crop development. However, the relationships of methylation polymorphisms with genetic polymorphisms, gene expression, and phenotypic variation in natural crop populations remain largely unknown. Here, we surveyed high-quality methylomes, transcriptomes, and genomes obtained from the 20-days-post-anthesis (DPA) cotton fibers of 207 accessions and extended the classical framework of population genetics to epigenetics. Over 287 million single methylation polymorphisms (SMPs) were identified, 100 times more than the number of single nucleotide polymorphisms (SNPs). These SMPs were significantly enriched in intragenic regions while depleted in transposable elements. Association analysis further identified a total of 5,426,782 cis-methylation quantitative trait loci (cis-meQTLs), 5078 cis-expression quantitative trait methylation (cis-eQTMs), and 9157 expression quantitative trait loci (eQTLs). Notably, 36.39% of cis-eQTM genes were not associated with genetic variation, indicating that a large number of SMPs associated with gene expression variation are independent of SNPs. In addition, out of the 1715 epigenetic loci associated with yield and fiber quality traits, only 36 (2.10%) were shared with genome-wide association study (GWAS) loci. The construction of multi-omics regulatory networks revealed 43 cis-eQTM genes potentially involved in fiber development, which cannot be identified by GWAS alone. Among these genes, the role of one encoding CBL-interacting protein kinase 10 in fiber length regulation was successfully validated through gene editing. Taken together, our findings prove that DNA methylation data can serve as an additional resource for breeding purposes and can offer opportunities to enhance and expedite the crop improvement process.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"34 12","pages":"859-872"},"PeriodicalIF":28.1,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41422-024-01027-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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