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Insights into the mechanisms of body weight control. 对体重控制机制的洞察。
IF 1.7 4区 教育学 Q2 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2026-03-01 Epub Date: 2025-12-18 DOI: 10.1152/advan.00091.2025
Sandra Pereira

Body weight plays an important role in health. Despite key findings associated with body weight control, many underlying physiological mechanisms still need to be discovered. In body weight control, the brain is the integrating center that receives information from the external and internal environments and ultimately enacts a response. Our brains seem to be wired to ensure survival because it appears that it is easier to gain weight than to lose it. In the present review, the current understanding of the mechanisms of body weight control by nutrients and hormones, with a focus on leptin, insulin, and glucagon-like peptide-1 (GLP-1), is discussed. Gaps in the literature are also highlighted.NEW & NOTEWORTHY This review provides a brief summary of the key current mechanisms of body weight regulation.

体重对健康起着重要作用。尽管有了与体重控制相关的关键发现,但许多潜在的生理机制仍有待发现。在体重控制中,大脑是接收来自外部和内部环境的信息并最终做出反应的整合中心。我们的大脑似乎与确保生存息息相关,因为看起来增重比减重更容易。本文综述了目前对营养物质和激素控制体重的机制的理解,重点讨论了瘦素、胰岛素和胰高血糖素样肽-1 (GLP-1)。文献中的空白也被强调。
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引用次数: 0
Assessing the use of cardiac ultrasound as an adjunct to physiology education at the medical school level. 评估心脏超声在医学院生理学教学中的辅助作用。
IF 1.7 4区 教育学 Q2 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2026-03-01 Epub Date: 2025-12-23 DOI: 10.1152/advan.00216.2025
Sydney R Sudler, Spencer A Vroegop, Halley M McDonald, Ethan Weiss, Derek Dennard, Chase Irwin, Charles Finch, Layla Al-Nakkash

At Midwestern University-Glendale, hands-on point-of-care ultrasound (POCUS) training is integrated throughout the 4-year medical curriculum. The core physiology courses are completed by all first-year osteopathic medical students [Arizona College of Osteopathic Medicine (AZCOM)] and podiatric medical students [Arizona College of Podiatric Medicine (AZPOD)]. We hypothesized that the incorporation of a cardiac ultrasound workshop would enhance students' perceived confidence in their understanding of cardiac physiology and increase students' perceived confidence to perform cardiac POCUS scans and, additionally, that student perceived confidence in either area of cardiac physiology or POCUS may affect either or both of these metrics. The study utilized brief pre- and postworkshop surveys, administered on paper; questions assessed confidence in cardiac physiology and ultrasound principles and perceived gains in understanding and practical skills measuring cardiac output (CO), velocity time integral (VTI), measurement of aortic diameter, and E-point septal separation (EPSS). Additionally, all student participant-captured images were evaluated by a clinical faculty expert in ultrasound instruction using a grading rubric based on image clarity and anatomical and measurement accuracy. The pre- and postsurvey analyses demonstrated 1) significantly increased confidence in basic ultrasound machine use and 2) significantly increased confidence in obtaining the parasternal long axis (PLAX) view, integral to measuring CO, VTI, and EPSS, and that 3) participants with lower baseline confidence in physiology showed greater overall gains in confidence in obtaining the PLAX view and 4) participants with higher prior POCUS confidence reported significantly higher subjective learning in cardiac physiology. Average scores for all images assessed fell into the "fair" category for image clarity and anatomical and measurement accuracy. Our findings offer evidence of and meaningful insights into the educational value of integrating POCUS-based learning experiences within medical physiology courses.NEW & NOTEWORTHY This study assesses the utility of cardiac ultrasound workshops within a medical physiology course. Students were surveyed; stratifying respondents into high- and low-prior confidence groups, we demonstrate which students may benefit the most from hands-on ultrasound workshops. Additionally, students' technical skill proficiency in POCUS was assessed and evaluated from images of cardiac anatomical structures and corresponding physiological measurements. The large experimental group utilized (291 surveys) yields increased sensitivity and supports significant findings.

在中西部大学格伦代尔分校,实践护理点超声(POCUS)培训被整合到整个4年的医学课程中。核心生理学课程由所有一年级骨科医学学生(AZCOM)和足病医学学生(AZPOD)完成。我们假设合并心脏超声研讨会将增强学生对心脏生理学理解的感知信心,并增加学生对心脏POCUS扫描的感知信心,此外,学生对心脏生理学或POCUS任一领域的感知信心可能会影响这些指标中的一项或两项。这项研究采用了简短的研讨会前后调查,以书面形式进行;问题评估了对心脏生理学和超声原理的信心,对心输出量(CO)、速度时间积分(VTI)、主动脉直径测量和e点间隔分离(EPSS)的理解和实践技能的感知增益。此外,所有学生参与者捕获的图像由临床超声教学专家使用基于图像清晰度,解剖和测量准确性的分级标准进行评估。调查前后的分析显示:(1)对基本超声仪器使用的信心显著增加,(2)对获得胸骨旁长轴(PLAX)视图的信心显著增加,这是测量CO, VTI和EPSS的组成部分,(3)生理基线信心较低的参与者对获得PLAX视图的信心总体增加,(4)先前POCUS信心较高的参与者报告了显著更高的心脏生理学主观学习。在图像清晰度、解剖结构和测量精度方面,所有评估图像的平均得分都属于“公平”类别。我们的研究结果为医学生理学课程中整合基于pocus的学习经验的教育价值提供了证据和有意义的见解。
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引用次数: 0
Endometriosis: pathophysiology and the potential role of diet. 子宫内膜异位症:病理生理学和饮食的潜在作用。
IF 1.7 4区 教育学 Q2 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2026-03-01 Epub Date: 2025-12-12 DOI: 10.1152/advan.00198.2025
Lillian H Wilder, Hannah E Cabre, Madison S Dickey, Leanne M Redman

Endometriosis (ENDO) is a chronic, estrogen-dependent condition affecting over 190 million females worldwide. Characterized by cyclic pelvic pain, infertility, and systemic inflammation, its symptoms profoundly impact quality of life, interfering with mental health, relationships, education, work, and sexual well-being. Despite this burden, treatment options remain limited. For symptom relief, many females turn to self-management strategies, particularly dietary modifications. This review explores the relationship between ENDO, quality of life, and diet. First, we summarize the ENDO classification and assessment. Second, we provide an overview of the pathophysiology and etiology of ENDO including current diagnosis methods. Finally, we review evidence on anti-inflammatory and elimination diets, such as the Mediterranean and low fermentable oligo-, di-, monosaccharides and polyols (low-FODMAP) diets, which are adopted to reduce ENDO-associated pain through inflammatory and estrogen-mediated mechanisms. Retrospective studies suggest the adoption of diets with anti-inflammatory properties may improve ENDO symptoms and quality of life, yet high-quality randomized controlled trials remain scarce. Before clinical recommendations regarding dietary management strategies for ENDO are developed, rigorous and comprehensive randomized trials are needed.NEW & NOTEWORTHY This review synthesizes current evidence for the potential of utilizing diet as a nonpharmacological strategy for managing endometriosis-associated pain and other symptomatology. It emphasizes the importance of addressing patient-identified barriers and patient-centered research designs. By bridging clinical findings with current data, this work offers educators and clinicians a more holistic framework to guide discussions around symptom management and the role of nutrition in chronic disease care.

子宫内膜异位症(ENDO)是一种慢性雌激素依赖性疾病,影响全球超过1.9亿女性。以周期性盆腔疼痛、不孕症和全身性炎症为特征,其症状严重影响生活质量,干扰心理健康、人际关系、教育、工作和性生活。尽管有这种负担,但治疗选择仍然有限。为了缓解症状,许多女性转向自我管理策略,特别是饮食调整。这篇综述探讨了ENDO、生活质量和饮食之间的关系。首先,我们总结了ENDO的分类和评估。其次,我们提供了病理生理学和病因的概述,包括目前的诊断方法。最后,我们回顾了抗炎和消除饮食的证据,如地中海和低fodmap饮食,它们通过炎症和雌激素介导的机制来减少内啡肽相关的疼痛。回顾性研究表明,采用具有抗炎特性的饮食可以改善ENDO症状和生活质量,但高质量的随机对照试验仍然很少。在制定关于ENDO饮食管理策略的临床建议之前,需要进行严格和全面的随机试验。
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引用次数: 0
Implementing an integrated epistemic framework: a multimodal active learning approach in translational neuroscience. 实现一个集成的认知框架:在转化神经科学中的多模态主动学习方法。
IF 1.7 4区 教育学 Q2 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2026-03-01 Epub Date: 2025-11-18 DOI: 10.1152/advan.00160.2025
Kambiz N Alavian

The theoretical and practical aspects of science education are often uncoupled, resulting in decontextualized learning. To address this concern, the present work adopts the view that scientific discovery is a form of learning and that its hypothetico-deductive and transformative processes are essential for learning in scientific disciplines. This article presents an educational practice developed for a graduate-level translational neuroscience module, centered on the process of scientific inquiry through student-led, hypothesis-driven research design. The project adopts a multimodal framework, based on multiple pedagogical and philosophical concepts including transformative learning, threshold concepts, social constructivism, and the philosophies of Popper and Kuhn, to integrate content knowledge with epistemological development. By mirroring the logistics and logic of scientific discovery, and through iterative cycles of discussion, reflection, and critical evaluation, the students navigate both cognitive and affective domains and engage with complex and often troublesome topics in translational neuroscience.NEW & NOTEWORTHY Grounded in Popper's hypothetico-deductive logic, Kuhn's focus on anomalies, threshold concepts, and transformative learning, the Virtual Research Project (VRP) turns the scientific method into pedagogy.

科学教育的理论和实践方面往往是不耦合的,导致非情境化的学习。为了解决这一问题,本研究采用了这样一种观点,即科学发现是一种学习形式,其假设-演绎和转化过程对科学学科的学习至关重要。本文介绍了为研究生水平的转化神经科学模块开发的教育实践,通过学生主导的、假设驱动的研究设计,以科学探究的过程为中心。该项目采用多模态框架,基于多种教学和哲学概念,包括变革学习、门槛概念、社会建构主义以及波普尔和库恩的哲学,将内容知识与认识论发展相结合。通过反映科学发现的逻辑和逻辑,通过讨论、反思和批判性评估的迭代循环,学生们可以在认知和情感领域中导航,并参与转化神经科学中复杂且经常棘手的主题。
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引用次数: 0
A pedagogical initiative promoting Exercise is Medicine® for cancer prevention and supportive care. 促进运动的教学倡议是癌症预防和支持性护理的医学®。
IF 1.7 4区 教育学 Q2 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2026-03-01 Epub Date: 2025-12-24 DOI: 10.1152/advan.00187.2025
Laura A Richardson, Steven J Elmer, Sandra K Knecht, Dennis J Kerrigan, Melissa M Sherman, Garett J Griffith

Cancer is a major global health challenge. Despite strong evidence supporting exercise in cancer prevention and care, its integration into treatment plans remains limited. This article outlines an experiential learning initiative combining cancer prevention, exercise physiology, and innovative teaching to raise awareness of exercise in cancer prevention and supportive care. An interdisciplinary team from a professional organization designed and implemented an Exercise is Medicine® video-based challenge. Undergraduate students created short, evidence-based videos that highlighted exercise's role in cancer prevention and care. Submissions were evaluated by the team and also shared for public voting at an annual regional conference. The challenge engaged 14 students, producing 12 videos with credible evidence and creative media. Finalist videos, promoted through social media and professional networks, generated >1,000 views, broadening awareness of exercise oncology. Awards recognized top submissions, encouraging student engagement, collaboration, and advocacy for exercise in supportive cancer care. The initiative showed that students could synthesize and communicate complex scientific concepts effectively. This novel, student-driven initiative demonstrated that experiential learning can be meaningfully integrated into physiology principles of oncology care. By engaging students in creative, evidence-based communication, the project deepened understanding of exercise's pathophysiological basis in cancer care and stressed multidisciplinary collaboration. This scalable educational model raises awareness of exercise oncology among future health professionals and supports a workforce ready to deliver patient-centered, evidence-based cancer care.NEW & NOTEWORTHY This article outlines the intersection of cancer prevention, exercise physiology education, and pedagogical innovation. An exercise oncology initiative was used to educate students on the role of exercise in cancer prevention and supportive care through a video-based challenge. Participants integrated exercise physiology into cancer care advocacy, promoting collaborative care. The initiative raised awareness of exercise oncology and created a scalable framework for future education, emphasizing multidisciplinary collaboration in supportive cancer care.

癌症是一项重大的全球健康挑战。尽管有强有力的证据支持锻炼在癌症预防和治疗中的作用,但将其纳入治疗计划的程度仍然有限。本文概述了一项结合癌症预防、运动生理学和创新教学的体验式学习倡议,以提高运动在癌症预防和护理中的意识。来自专业组织的跨学科团队设计并实施了基于视频的“运动是医学”挑战。本科生制作了以证据为基础的短视频,突出了锻炼在癌症预防和治疗中的作用。提交的作品由团队进行评估,并在年度区域会议上进行公众投票。14名学生参与了这项挑战,用可信的证据和创造性的媒体制作了12个视频。通过社交媒体和专业网络推广的入围视频产生了超过1000次的观看量,扩大了人们对运动肿瘤学的认识。奖项认可了最好的提交,鼓励学生参与,合作和倡导癌症治疗中的锻炼。这一举措表明,学生能够有效地综合和交流复杂的科学概念。这种新颖的,学生驱动的倡议表明,体验式学习可以有意义地整合到肿瘤护理的生理学原理。通过让学生参与创造性的、基于证据的交流,该项目加深了对运动在癌症治疗中的病理生理基础的理解,并强调了多学科合作。这种可扩展的教育模式提高了未来健康专业人员对运动肿瘤学的认识,并支持一支以患者为中心、以证据为基础的癌症护理队伍。
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引用次数: 0
Effective mentoring in the academic biomedical sciences: a collaborative effort that takes a village. 在学术生物医学科学方面的有效指导:需要全村协作的努力。
IF 1.7 4区 教育学 Q2 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2026-03-01 Epub Date: 2025-12-18 DOI: 10.1152/advan.00247.2025
John Henry Dasinger, Barbara T Alexander

NEW & NOTEWORTHY Mentoring can be one of the most rewarding components of a career in academic science and research. This article outlines key guidelines for establishing a successful mentor-mentee relationship, creating a supportive environment that fosters professional and scientific growth and discovery.

这不仅需要一个村庄来训练你在学术科学和研究方面的职业生涯,而且也需要一个村庄来成为一个成功的科学家和在你的职业生涯中的导师。好导师的定义是什么?如何建立良好的师徒关系?对师弟关系的洞察包括几个关键因素,当与对指导的热情相结合时,可以导致学术研究和科学职业生涯中最有价值的组成部分之一。然而,一个成功的师徒关系也需要合作的努力。指导包括对导师和被徒弟角色的清晰理解,被徒弟在设定目标和掌握自己的专业发展方面发挥积极作用。
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引用次数: 0
How are States Guiding Educators’ Implementation of Specially Designed Instruction: A Policy Documentation Review 国家如何引导教育工作者实施专门设计的教学:政策文件审查
IF 2.8 3区 教育学 Q1 EDUCATION, SPECIAL Pub Date : 2026-02-09 DOI: 10.1177/00144029251413482
Bradley S. Witzel, Jonté A. Myers, Pamela J. Mims
Specially Designed Instruction (SDI) is a legal and educational mandate that ensures students with disabilities receive individualized, evidence-based interventions to enhance their academic and behavioral outcomes. However, SDI is inconsistently implemented due to varying state policies, limited educator guidance, and disparities in defining research or evidence-based practices (EBPs). This study examined how state laws define and regulate SDI as well as incorporate EBPs to ensure instructional fidelity. We systematically analyzed state laws and policies to identify similarities, gaps, and inconsistencies within definitions of SDI, EBPs, and recommended instructional strategies. Findings indicate the need for a standardized definition of SDI, more precise policy guidance as to the planning and delivery of EBPs, and enhanced educator training to improve student outcomes.
特别设计指导(SDI)是一项法律和教育授权,确保残疾学生接受个性化的、基于证据的干预,以提高他们的学业和行为成绩。然而,由于各州政策不同,教育工作者指导有限,以及在定义研究或循证实践(ebp)方面存在差异,SDI的实施并不一致。本研究考察了州法律如何定义和规范SDI以及纳入ebp以确保教学保真度。我们系统地分析了各州的法律和政策,以确定SDI、ebp定义中的相似点、差距和不一致之处,并推荐了教学策略。研究结果表明,需要对SDI进行标准化定义,对ebp的规划和实施进行更精确的政策指导,并加强对教育工作者的培训,以提高学生的成绩。
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引用次数: 0
Missing Data Reporting and Handling in Special Education Group Intervention Research 特殊教育群体干预研究中的缺失数据报告与处理
IF 2.8 3区 教育学 Q1 EDUCATION, SPECIAL Pub Date : 2026-02-09 DOI: 10.1177/00144029251410299
Daniel R. Espinas, Alexis Swanz, Allyson L. Hanson, Jessica A. R. Logan
We conducted a systematic review of missing data handling and reporting in a 1-year cross-section (2020) of group design special education intervention research. We identified 121 intervention studies. Of these 72 (60%) reported missing data at the case, variable, or item level. Few studies examined the mechanism underlying their missing data and most handled the missingness with either complete case analysis (listwise) or pairwise deletion. We discuss the implications of these findings and offer recommendations for improved reporting and handling methods.
我们对一项为期1年(2020年)的群体设计特殊教育干预研究中缺失的数据处理和报告进行了系统回顾。我们确定了121项干预研究。其中72例(60%)报告了病例、变量或项目级别的数据缺失。很少有研究检查了缺失数据背后的机制,大多数研究都是通过完整的病例分析(列表法)或两两删除来处理缺失的。我们讨论了这些发现的含义,并提出了改进报告和处理方法的建议。
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引用次数: 0
Mutual gains: Non-presenting undergraduate attendance at regional scientific meetings benefits students and scientific societies. 互惠互利:不出席区域科学会议的本科生使学生和科学社团受益。
IF 1.7 4区 教育学 Q2 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2026-02-09 DOI: 10.1152/advan.00213.2025
Alex M Champagne, Sabrina E Dunning, Maryam H Mahmoud, Elissa T Fisher, Sara N Shah, Heidi E Walsh

Participation in scientific meetings confers many benefits to undergraduate students and promotes their success and retention in science. However, the cost and time required to attend a scientific meeting is often prohibitive for students, and university funding is often restricted to students presenting research. Small regional scientific meetings offer an opportunity to promote non-presenting undergraduate attendance because of their reduced registration fees and travel time, but the benefits of attending regional scientific meetings have not been extensively studied. We recruited 45 non-presenting undergraduate students to attend the annual meeting of the Indiana Physiological Society and provided students with pre- and post-meeting surveys measuring self-perceptions of their professional abilities, sense of belonging in science, confidence in their degree program and career pathway, and reflections on the conference experience. Additionally, because non-presenting undergraduates made up nearly half of all meeting attendees, we surveyed other meeting attendees to assess the impact of these students on the meeting environment. After attending the meeting, students reported increased confidence talking to other scientists and presenting future research, a greater sense of belonging within the scientific community, more interest in pursuing research after graduation, and increased enthusiasm to attend future meetings. Other meeting attendees felt that the non-presenting undergraduates had a positive impact on the meeting and enhanced the environment for student presenters. Our results suggest that the attendance of non-presenting undergraduates at small regional scientific meetings provides mutual benefits to students, universities, and regional scientific societies.

参加科学会议给本科生带来了许多好处,并促进了他们在科学领域的成功和保留。然而,参加科学会议所需的费用和时间对学生来说往往是令人望而却步的,而大学的资助往往仅限于展示研究成果的学生。小型区域科学会议提供了一个机会,以促进不出席的本科生出席,因为他们减少了注册费和旅行时间,但参加区域科学会议的好处还没有得到广泛的研究。我们招募了45名未出席印第安纳生理学会年会的本科生,并为学生提供了会前和会后的调查,测量他们对专业能力的自我认知、对科学的归属感、对学位课程和职业道路的信心,以及对会议经历的反思。此外,由于未出席会议的本科生占所有与会者的近一半,我们调查了其他与会者,以评估这些学生对会议环境的影响。参加会议后,学生们报告说,与其他科学家交谈和展示未来研究的信心增加了,在科学界有了更大的归属感,毕业后对从事研究的兴趣更大,参加未来会议的热情也增加了。其他与会者认为,不发言的本科生对会议产生了积极的影响,并改善了学生发言的环境。我们的研究结果表明,不出席小型区域科学会议的本科生为学生、大学和区域科学社团提供了互利。
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引用次数: 0
Exploring implementation of the UK Misogyny in Music report’s recommendations to address gender inequalities in music education in England 探索英国《音乐中的厌女症》报告建议的实施情况,以解决英国音乐教育中的性别不平等问题
IF 2 3区 教育学 Q3 EDUCATION & EDUCATIONAL RESEARCH Pub Date : 2026-02-09 DOI: 10.1017/s0265051726100679
Anna Bull
In 2024, the Women and Equalities Select Committee in the UK Parliament published a report entitled Misogyny in Music . It included the recommendations that ‘music colleges, conservatoires and other educational settings need to do more to address the gendering of instruments, roles and genres and improve the visibility of and support for female role models’. While there is a dearth of policy levers available to implement this recommendation, this article critically analyses three existing policy/regulatory frameworks that could be used for its implementation in England. The article also highlights a significant limitation of the report – its exclusion of trans and non-binary musicians.
2024年,英国议会妇女与平等特别委员会发表了一份题为《音乐中的厌女症》的报告。报告建议,“音乐学院、音乐学院和其他教育机构需要采取更多措施,解决乐器、角色和流派的性别问题,提高女性榜样的知名度和支持度。”虽然缺乏可用于实施这一建议的政策杠杆,但本文批判性地分析了可用于在英国实施这一建议的三个现有政策/监管框架。文章还强调了该报告的一个重大局限性-它排除了跨性别和非二元音乐家。
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引用次数: 0
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