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Nanotechnology based devices and applications in medicine: An overview 基于纳米技术的设备及其在医学中的应用:综述
Pub Date : 2012-01-01 DOI: 10.4103/2229-5186.94320
E. Martis, Rewa R Badve, Mukta D Degwekar
Nanotechnology has been the most explored and extensively studied area in recent times. Many devices which were earlier impossible to imagine, are being developed at a lightning speed with the application of nanotechnology. To overcome the challenges offered by the most dreaded diseases, such as cancer or any disease involving the central nervous system or other inaccessible areas of the human body, nanotechnology has been proved to be a boon in making the treatment more target specific and minimizing the toxicities. This review describes a handful of important devices and applications based on nanotechnology in medicine made in recent times. This article also describes in brief the regulatory concerns and the ethical issues pertaining to nanomedical devices.
纳米技术是近年来探索和广泛研究最多的领域。由于纳米技术的应用,许多以前无法想象的设备正在以闪电般的速度发展。为了克服最可怕的疾病所带来的挑战,例如癌症或任何涉及中枢神经系统或人体其他难以触及的区域的疾病,纳米技术已被证明是一种福音,它使治疗更有针对性,并将毒性降到最低。本文综述了近年来基于纳米技术在医学上的一些重要设备和应用。本文还简要介绍了与纳米医疗设备有关的监管问题和伦理问题。
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引用次数: 39
A study of psychiatric morbidity in patients of peptic ulcer diseases 消化性溃疡患者精神疾病发病率的研究
Pub Date : 2012-01-01 DOI: 10.4103/2229-5186.94310
J. Klair, B. Sidhu
Aims and Objectives: To study the prevalence of psychiatric morbidity among patients of peptic ulcer disease and to study the patients of peptic ulcer disease with psychiatric morbidity in comparison to patients of peptic ulcer disease without psychiatric morbidity on following variables: sociodemographic variables and attributes/risk factors of peptic ulcer disease. Materials and Methods: Fifty cases of clinically proven acid peptic diseases and 30 cases of the control group were screened in department of General Medicine, outdoor as well as indoor patients. Instruments applied for the purpose of the study were Personal Bio-data Performa (Appendix-I), (SCL)- 80 (Appendix-II), Hamilton rating scale for anxiety and depression, (P.S.L.E.); clinical diagnosis of psychiatric disorders was made as per ICD- 10 criteria. Data collected shall be subjected to statistical analysis. Results and Findings: The psychiatric morbidity was significantly ( P P P P P P P P 10 years, compared to 23.80% in patients without psychiatric morbidity. Lastly, 48.27% of patients with psychiatric morbidity had significantly ( P Conclusions: There is a significant relationship between the peptic ulcer disease and the various psychiatric morbidity factors as illustrated from the findings of this study.
目的:研究消化性溃疡患者中精神疾病的患病率,并将消化性溃疡患者中有精神疾病的患者与无精神疾病的消化性溃疡患者进行比较,研究消化性溃疡的社会人口学变量和消化性溃疡的属性/危险因素。材料与方法:选取全科、室外及室内患者中经临床证实的胃酸消化性疾病患者50例,对照组30例。本研究使用的工具为个人生物数据量表(附录i), (SCL)- 80(附录ii),汉密尔顿焦虑和抑郁评定量表(P.S.L.E.);按照ICD- 10标准对精神障碍进行临床诊断。收集的数据应进行统计分析。结果与发现:10年精神病发病率P P P P P P P显著高于无精神病发病率P P P P P的23.80%。结论:本研究结果表明消化性溃疡与各种精神疾病发病因素之间存在显著的关系。
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引用次数: 0
Antibiotic coresistance among extended-spectrum beta lactamase-producing urinary isolates in a tertiary medical center: A prospective study 三级医疗中心产β -内酰胺酶尿分离株的抗生素共耐药:一项前瞻性研究
Pub Date : 2012-01-01 DOI: 10.4103/2229-5186.94318
N. Das, AK Borthakur
Aim: Urinary tract infections are among the most common infections encountered in clinical practice. Study was conducted to detect extended-spectrum beta lactamase (ESBL) type of resistance in urinary isolates in North Eastern Region of India. Materials and Methods: Midstream urine sample was collected from 200 patients clinically suspected to be suffering from urinary tract infections and attending Outpatients Departments and different wards in Assam Medical College and Hospital Dibrugarh, a tertiary teaching hospital from September 2007 to August 2008. The patients who did not have a course of antibiotic before 15 days of study were included, whereas patients with known history of diabetes, thyroid disorders, renal disease, and hypertension were excluded from the study group. Urine samples were cultured as per guidelines and ESBL detected by double disc diffusion tests. Statistical Analysis: Test of proportion and two-tailed Z test were used for data analysis. Results: In all, 171 isolates of Gram-negative bacilli were detected of which 42 isolates produced ESBL. So the detection rate of ESBL in the study was 24.56%. The ESBL-producing isolates were 19 (28.78%) in males and 23 (21.9%) in females, and this difference was not found to be significant ( P > 0.05). In 97.61% of isolates, associated resistance was observed for ampicillin and cotrimoxazole. Ciprofloxacin and gatifloxacin showed coresistance of 69.04% and 71.42%, respectively. Associated resistance for amoxycillin/clavulanic acid and piperacillin/tazobactum was 38.09% and 35.71%. All the isolates of Enterobacteriaceae producing ESBL were 100% sensitive to imipenem. Conclusion: These data provided the much needed information on the prevalence of antimicrobial resistance among pathogens causing urinary tract infections. Results seem helpful in providing useful guidelines in choosing an effective antibiotic in cases with urinary tract infection and also initiating therapy in antimicrobial-resistant strains.
目的:尿路感染是临床最常见的感染之一。对印度东北地区尿分离株进行了广谱β -内酰胺酶(ESBL)型耐药检测。材料与方法:收集2007年9月至2008年8月在阿萨姆邦医学院和三级教学医院迪布鲁加尔医院门诊和不同病房就诊的200例临床疑似尿路感染患者的中程尿液样本。研究前15天未使用过抗生素的患者被纳入研究范围,而已知有糖尿病、甲状腺疾病、肾脏疾病和高血压病史的患者被排除在研究范围之外。尿液样本按照指南进行培养,并通过双椎间盘扩散试验检测ESBL。统计分析:采用比例检验和双尾Z检验进行数据分析。结果:共检出革兰氏阴性杆菌171株,产生ESBL 42株。本组ESBL检出率为24.56%。产esbl的菌株雄性19株(28.78%),雌性23株(21.9%),差异无统计学意义(P > 0.05)。97.61%的分离菌对氨苄西林和复方新诺明均有耐药。环丙沙星与加替沙星共耐药率分别为69.04%和71.42%。阿莫西林/克拉维酸和哌拉西林/他唑巴坦的相关耐药率分别为38.09%和35.71%。产ESBL的肠杆菌科分离株对亚胺培南的敏感性均为100%。结论:这些数据为了解尿路感染病原菌耐药情况提供了必要的信息。结果似乎有助于为尿路感染病例选择有效的抗生素提供有用的指导,也有助于对耐药菌株进行治疗。
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引用次数: 14
Nanoparticles - A paradigm for topical drug delivery 纳米颗粒-局部给药的范例
Pub Date : 2012-01-01 DOI: 10.4103/2229-5186.94311
Yogesh S. Chaudhari
Topical drug delivery is still a challenge due to the difficulties in controlling the active pharmaceutical ingredient (API) fate within the skin. Due to the safety of the component material and controlled release abilities, nanoparticles offer an excellent opportunity for the rational delivery of drugs to the desired target site and hence these carrier systems are effectively used for topical delivery of variety of active principles for both pharmaceutical as well as cosmetic purposes. Recently, solid lipid nanoparticles (SLNs) have shown a great potential as carriers for topical administration of active substances, principally owing to the possible targeting effect and controlled release in different skin strata. Also, nanostructured lipid carriers (NLCs) are a new type of topical delivery system offering improved performance in terms of drug loading and long-term stability with the ability to form highly concentrated dispersions. Another invention in the field of topical drug delivery is the use of micellar nanoparticles (MNPs) that offer a potentially fast and inexpensive pharmaceutical development model by using drugs already proven safe and effective to create new proprietary formulations. These novel drug delivery systems have gained much interest as they combine both the technology of lipid sciences and nanosciences, and hence may be better alternative carriers.
由于难以控制活性药物成分(API)在皮肤内的命运,局部药物递送仍然是一个挑战。由于成分材料的安全性和可控释放能力,纳米颗粒为药物的合理递送提供了极好的机会,因此这些载体系统有效地用于药物和化妆品目的的各种活性成分的局部递送。近年来,固体脂质纳米颗粒(SLNs)作为外用活性物质的载体显示出巨大的潜力,主要是由于其可能的靶向作用和在不同皮肤层的控释。此外,纳米结构脂质载体(nlc)是一种新型的局部给药系统,在药物负载和长期稳定性方面具有改进的性能,能够形成高度浓缩的分散体。局部给药领域的另一项发明是使用胶束纳米颗粒(MNPs),它通过使用已经被证明安全有效的药物来创建新的专有配方,提供了一种潜在的快速和廉价的药物开发模式。这些新型药物输送系统结合了脂质科学和纳米科学技术,因此可能是更好的替代载体,因此引起了人们的极大兴趣。
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引用次数: 10
Promising future of probiotics for human health: Current scenario 益生菌对人类健康的前景:现状
Pub Date : 2012-01-01 DOI: 10.4103/2229-5186.94308
G. Tiwari, R. Tiwari, S. Pandey, P. Pandey
Probiotics are nonpathogenic microorganisms mostly of human origin which, when administered in adequate amounts, confer a health benefit on the host and enable to prevent or improve some diseases. Probiotics may be a natural temporary constituent of the resident intestinal microflora, but their concentration is not sufficient for therapeutic purposes. The microbiota, the intestinal epithelium, and the mucosal immune system constitute the gastrointestinal ecosystem. All three components are essential for complete functional and developmental maturity of the system. Probiotics are defined as live microbial food ingredients that have a beneficial effect on human health. The use of antibiotics, immunosuppressive therapy, and irradiation, among other means of treatment, may cause alterations in the composition and have an effect on the gastrointestinal tract flora. Therefore, the introduction of beneficial bacterial species to GI tract may be a very attractive option to re-establish the microbial equilibrium and prevent disease. The efficacy of probiotics in acute enteric infections and post-antibiotic syndromes is now established and there is emerging evidence for a role in necrotizing enterocolitis, irritable bowel syndrome, periodontal diseases, and some forms of inflammatory bowel disease.
益生菌是一种非致病性微生物,主要来自人类,当给予足够的量时,可以给宿主带来健康益处,并能够预防或改善某些疾病。益生菌可能是常驻肠道菌群的天然临时成分,但其浓度不足以达到治疗目的。微生物群、肠上皮和粘膜免疫系统构成胃肠道生态系统。这三个组件对于系统的完整功能和开发成熟度都是必不可少的。益生菌被定义为对人体健康有益的活微生物食品成分。除其他治疗手段外,抗生素、免疫抑制治疗和照射的使用可能导致组合物的改变并对胃肠道菌群产生影响。因此,引入有益菌种到胃肠道可能是一个非常有吸引力的选择,以重建微生物平衡和预防疾病。益生菌对急性肠道感染和抗生素后综合征的疗效现已确定,并且有新的证据表明益生菌在坏死性小肠结肠炎、肠易激综合征、牙周病和某些形式的炎症性肠病中起作用。
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引用次数: 33
Evaluation of wound healing potential of Pterocarpus marsupium heart wood extract in normal and diabetic rats 有袋翼树心木提取物对正常和糖尿病大鼠伤口愈合潜力的评价
Pub Date : 2012-01-01 DOI: 10.4103/2229-5186.94313
A. Singhal, Manisha Gupta, S. Edwin, Rupesh Soni
Aim: The aim of the present study is to evaluate and compare the cutaneous wound healing potential of Pterocarpus marsupium in normal and diabetic rats and make inference for the cutaneous wound healing potential by possible mode of action P. marsupium extract. Materials and Methods: The effect of heart wood extract of P. marsupium on wound healing has been studied in diabetic and normal animals. The effect has also been compared with standard (mupirocin ointment) application. In the absence of specific animal model for cutaneous diabetic wound healing, we have used common model of wound healing (excision wound model) in animals having diabetes (by administration of alloxan monohydrate 120 mg/kg i.p.). Statistics Analysis: Data were analyzed by using one-way ANOVA, followed by Tukey's post hoc tests, using the Graph Pad Software (5.0 demo version), and P value Results and Conclusion : Rats treated with 200 mg/kg/day of P. marsupium heart wood extract had high rate of wound contraction, significantly decreased epithelization period, and significant increase in dry weight, wet weight, and hydroxyproline content of the granulation tissue when compared with the diabetic control and normal control groups. Wound contraction together with increased tensile strength and hydroxyproline content support the use of P. marsupium heart wood extract in the management of wound healing in normal and diabetic rats.
目的:对正常大鼠和糖尿病大鼠的皮肤创面愈合电位进行评价和比较,并通过有袋蕨提取物可能的作用方式对皮肤创面愈合电位进行推断。材料与方法:研究了袋草心木提取物对糖尿病动物和正常动物创面愈合的影响。效果也与标准应用(莫匹罗星软膏)进行了比较。在缺乏糖尿病皮肤创面愈合特异性动物模型的情况下,我们采用了糖尿病动物创面愈合的通用模型(切除创面模型)(通过给药一水四氧嘧啶120 mg/kg i.p)。统计分析:数据采用单因素方差分析,采用Tukey事后检验,使用Graph Pad软件(5.0演示版),P值。与糖尿病对照组和正常对照组相比,给药200 mg/kg/d的大鼠创面收缩率高,上皮细胞形成周期明显缩短,肉芽组织干重、湿重和羟脯氨酸含量显著增加。伤口收缩,增加抗拉强度和羟脯氨酸含量支持使用袋草心木提取物在伤口愈合管理正常和糖尿病大鼠。
{"title":"Evaluation of wound healing potential of Pterocarpus marsupium heart wood extract in normal and diabetic rats","authors":"A. Singhal, Manisha Gupta, S. Edwin, Rupesh Soni","doi":"10.4103/2229-5186.94313","DOIUrl":"https://doi.org/10.4103/2229-5186.94313","url":null,"abstract":"Aim: The aim of the present study is to evaluate and compare the cutaneous wound healing potential of Pterocarpus marsupium in normal and diabetic rats and make inference for the cutaneous wound healing potential by possible mode of action P. marsupium extract. Materials and Methods: The effect of heart wood extract of P. marsupium on wound healing has been studied in diabetic and normal animals. The effect has also been compared with standard (mupirocin ointment) application. In the absence of specific animal model for cutaneous diabetic wound healing, we have used common model of wound healing (excision wound model) in animals having diabetes (by administration of alloxan monohydrate 120 mg/kg i.p.). Statistics Analysis: Data were analyzed by using one-way ANOVA, followed by Tukey's post hoc tests, using the Graph Pad Software (5.0 demo version), and P value Results and Conclusion : Rats treated with 200 mg/kg/day of P. marsupium heart wood extract had high rate of wound contraction, significantly decreased epithelization period, and significant increase in dry weight, wet weight, and hydroxyproline content of the granulation tissue when compared with the diabetic control and normal control groups. Wound contraction together with increased tensile strength and hydroxyproline content support the use of P. marsupium heart wood extract in the management of wound healing in normal and diabetic rats.","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":"31 1","pages":"42"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88614299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Study of trends of poisoning in the cases reported to government hospital, Yavatmal 亚瓦塔马尔政府医院报告病例中毒趋势的研究
Pub Date : 2012-01-01 DOI: 10.4103/2229-5186.94321
Y. Vaidya, S. Hulke
Context: India is a developing country in south Asia. Rural population of this country is mostly dependant on agriculture. Pesticides, mainly the organophosphorus compounds are the most frequently used substances in agriculture and thus are easily accessible. Animal bites such as snake bite, scorpion bites are also common, as people here are mainly involved in the field work. Aims: This includes, knowing the pattern of poisoning in India along with various parameters, such as mode of poisoning, type of poison, outcome of the poisoning, the most vulnerable age group involved in poisoning, so that the study will help in rapid clinical diagnosis and immediate treatment of the cases leading to decreased mortality and morbidity. Setting and design: Retrospective observational study. Materials and Methods: The study was conducted at Govt. Hospital, Yavatmal. Poisoning cases reported to casualty and post-mortem cases of poisoning brought to the hospital from 01/06/2003 to 30/05/2004 were included in the study. Result: Total 1003 patients studied; acute poisoning in the age group of 21-30 years was the most common with higher frequency in males. Most common mode was suicidal. Most common agent responsible for poisoning was organophosphorus compounds followed by snake bite. Overall mortality due to poisoning was 12%. It was highest in insecticidal poisoning. Conclusion: It was seen that adults between 21 and 30 years of age were more prone to suicidal poisoning with organophosphorous compounds followed by accidental poisoning due to snake bite. Steps are needed to be taken to educate the people, to improve their socioeconomic status and also to provide better treatment facilities at grass root level.
背景:印度是南亚的一个发展中国家。这个国家的农村人口大多以农业为生。农药,主要是有机磷化合物,是农业中最常用的物质,因此很容易获得。动物咬伤,如蛇咬伤,蝎子咬伤也很常见,因为这里的人主要从事野外工作。目的:这包括,了解印度的中毒模式以及各种参数,如中毒模式,中毒类型,中毒结果,中毒最脆弱的年龄组,以便研究将有助于快速临床诊断和立即治疗导致死亡率和发病率降低的病例。背景和设计:回顾性观察性研究。材料和方法:研究在Yavatmal的政府医院进行。研究对象包括2003年6月1日至2004年5月30日期间送往医院的伤亡中毒报告个案及死后中毒个案。结果:共1003例患者;急性中毒以21 ~ 30岁年龄组最常见,以男性居多。最常见的模式是自杀。最常见的中毒原因是有机磷化合物,其次是蛇咬伤。中毒导致的总死亡率为12%。以杀虫剂中毒最高。结论:21 ~ 30岁的成年人以有机磷类化合物自杀性中毒发生率最高,其次为蛇咬意外中毒。需要采取措施教育人民,改善他们的社会经济地位,并在基层提供更好的治疗设施。
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引用次数: 19
Patient safety risk assessment and risk management: A review on Indian hospitals 患者安全风险评估与风险管理:对印度医院的回顾
Pub Date : 2011-10-01 DOI: 10.4103/2229-5186.93022
Gaurav Sharma, S. Awasthi, Anuj Dixit, Garima Sharma
This paper is intended to discuss a critical need expressed by present healthcare system of India, and how to provide a better health facility and diluting the medication errors caused by inappropriate management of the hospitals. Adverse events related to medication occur due to pathetic infrastructures, corporal punishment by the patient if unsatisfied, doctors on strike and working only for riches, trivial financial aid, and lack of basic amenities in the government-run hospitals of India. Government should reduce the barriers of awareness, accountability, ability, and action into accelerators of patient safety in the government organizations. Physicians, nurses, and pharmacists are truly the critical ingredient to rapid safety practice adoption. Various approaches like Technological Iatrogenesis, Computerized Provider Order Entry, and Electronic Health Record should be used. Although patient safety is recognized as a serious issue in health system, there is an urgent need for development and implementation of strategies for prevention and early detection of errors.
本文旨在讨论印度目前的医疗保健系统所表达的关键需求,以及如何提供更好的医疗设施和稀释由医院管理不当引起的用药错误。与药物有关的不良事件的发生是由于印度的基础设施不完善、病人不满意就会体罚、医生罢工和只为财富工作、微不足道的经济援助以及政府医院缺乏基本设施。政府应减少意识、问责、能力和行动方面的障碍,使其成为政府组织中患者安全的加速器。医生、护士和药剂师确实是快速采用安全实践的关键因素。应使用各种方法,如技术医疗发生、计算机化提供者订单输入和电子健康记录。虽然患者安全被认为是卫生系统中的一个严重问题,但迫切需要制定和实施预防和早期发现错误的战略。
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引用次数: 9
Antifilarial activity of gum from Moringa oleifera Lam. on human lymphatic filaria Brugia malayi 辣木树胶的抗丝活性研究。马来人淋巴丝虫病的研究
Pub Date : 2011-10-01 DOI: 10.4103/2229-5186.93025
V. Kushwaha, K. Saxena, S. Verma, V. Lakshmi, Rashmi Sharma, P. Murthy
Aim: Currently available antifilarial drugs diethylcarbamazine, ivermectin and albendazole and their combinations, are not able to control lymphatic filariasis. Therefore, a better antifilarial agent is urgently required for proper management of the disease. Materials and Methods: In this study, we evaluated the antifilarial activity of gum extract of plant Moringa oleifera Lam. against the human lymphatic filarial parasite Brugia malayi using adult worms and microfilariae (mf) in two in vitro assays (motility and inhition in MTT reduction) for viability and two animal models, primary (Meriones unguiculatus implanted with B. malayi adult worms in the peritoneal cavity) and secondary (subcutaneous B. malayi infective larvae induced Mastomys coucha, the model closer to the natural human filarial infection) screens. Results: The gum extract inhibited 100% motility (irreversible loss of motility) of mf and inhibited more than 56% MTT reduction potential of the adult female worms. The extract was safe in cytotoxicity test using Vero cell line, therefore followed in vivo in primary and secondary screens. In primary screen, the extract (5×500 mg/kg) caused 69% macrofilaricidal and 83% sterilization of female worms and 44% macrofilaricidal activity in secondary screen (5 × 1000 mg/kg) by oral route. Conclusion: Thus, it is concluded that the gum of the plant is macrofilaricidal in both in vitro and in vivo and may provide valuable leads for design and development of new antifilarial agents. This is the first ever report on the antifilarial efficacy of M. oleifera.
目的:目前已有的抗丝虫病药物乙基卡马嗪、伊维菌素和阿苯达唑及其联合用药均不能有效控制淋巴丝虫病。因此,迫切需要一种更好的抗丝虫药来适当地控制这种疾病。材料与方法:研究了辣木树胶提取物的抗丝活性。利用成虫和微丝虫(mf)对人淋巴丝虫病马来布鲁氏菌(Brugia malayi)的活性进行了两项体外实验(运动和抑制MTT降低),并对两种动物模型进行了筛选,一种是在腹膜腔内植入马来布鲁氏菌成虫,另一种是在皮下诱导马来布鲁氏菌感染幼虫,该模型更接近自然的人丝虫病感染)。结果:树胶提取物对成年雌虫100%的运动(不可逆运动丧失)和56%以上的MTT还原电位有抑制作用。该提取物在Vero细胞系细胞毒性试验中是安全的,因此在体内进行了一次和二次筛选。初筛(5×500 mg/kg)对雌虫的杀灭率为69%,绝育率为83%;二次筛(5× 1000 mg/kg)口服对雌虫的杀灭率为44%。结论:该植物树胶具有体外和体内的大丝虫杀灭作用,可为新型抗丝剂的设计和开发提供参考。这是迄今为止首次报道了油桐的抗丝虫作用。
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引用次数: 21
Drug delivery using alginate and chitosan beads: An Overview 海藻酸盐和壳聚糖微球给药综述
Pub Date : 2011-10-01 DOI: 10.4103/2229-5186.93023
R. Bhattarai, N. Dhandapani, Ayush Shrestha
Alginate and chitosan are commonly used polymers in modifying the drug release. These two polymers can be used together or separately to form drug loaded modified release beads. The ionotropic gelation method and a slight modification in various ways are used to prepare these beads of different characteristics. The bead characteristics like morphology, buoyancy, swelling nature, drug entrapment efficiency, adsorption, and release behavior are of importance. Also the therapeutic uses of the different modifications of the beads can be immense for the drugs which have low water solubility, short biological half life, require organ specific targeting, and are proteineous in nature.
海藻酸盐和壳聚糖是修饰药物释放的常用聚合物。这两种聚合物可以一起使用,也可以单独使用,形成载药改性释放珠。利用离子化凝胶法和各种方法的轻微改性制备了这些不同特性的微球。微球的形态、浮力、溶胀性、药物包封效率、吸附和释放行为等特征是重要的。此外,对于水溶性低、生物半衰期短、需要器官特异性靶向和本质上是蛋白质的药物,不同修饰珠的治疗用途可能是巨大的。
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引用次数: 22
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