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Drug Utilization Study in Pediatric Patients with Typhoid Fever 小儿伤寒患者的药物利用研究
Pub Date : 2023-05-15 DOI: 10.55544/jrasb.2.2.34
Prakruti K. Jadav, Pinal Sukharamwala, Nirmala Mehta
Drug utilization study was observational concurrent study in which 75 pediatric patients with culture or serologically proven typhoid fever were enrolled from 5 private children hospitals of Surat region during September to December, 2021. Information like age, sex, weight, treatment history, presenting symptoms, haematological and diagnostic test data, pattern of use of antibiotic including type, route, dose, frequency, duration and response of patient to drug in term of fever clearance time were collected in patient data collection form. The typhoid fever was predominantly found in patients of age between 2 to 10 years. Ceftriaxone was used in 86.6% of patients.  Only 18.3% patients had received dose of Ceftriaxone in range recommended by IAP and WHO i.e. between 75-100mg/kg. Rest patients had received drugs like cefixime, azithromycin, ofloxacin, ciprofloxacin, gatifloxacin or chloramphenicol alone or in combination. The clinical resistance with ceftriaxone was observed in 6% of patients. Mean fever clearance time with ceftriaxone used as single therapy was found to be 3.30 days, which was not significantly different from that of those patients who received its combination with other drugs. Anemia, moderate thrombocytopenia and leukocytosis were found in 50.7%, 9.3% and 14.7% of patients respectively. The predominant features were fever (100%), anorexia (63.33%) followed by cough (25.33%), abdominal pain (24%) and diarrhea (18.6%). In Surat region, ceftriaxone is commonly used antimicrobial in hospitalized children with typhoid fever. Treatment protocol is not matched with IAP guideline but matched with trend of antibiotic used in another region. Indiscriminate use of drug is one of the important factors leading to drug resistance.
药物利用研究是一项观察性并发研究,于2021年9月至12月从苏拉特地区5家私立儿童医院招募75例培养或血清学证实的伤寒患儿。在患者资料收集表中收集患者的年龄、性别、体重、治疗史、症状、血液学及诊断试验资料、抗生素使用方式(包括抗生素的种类、途径、剂量、使用频率、持续时间、退热时间等)等信息。伤寒主要见于年龄在2至10岁之间的病人。86.6%的患者使用头孢曲松。只有18.3%的患者接受了IAP和WHO推荐范围内的头孢曲松剂量,即75-100mg/kg。其余患者单独或联合使用头孢克肟、阿奇霉素、氧氟沙星、环丙沙星、加替沙星或氯霉素等药物。6%的患者出现头孢曲松临床耐药。头孢曲松单药治疗的平均退热时间为3.30天,与其他药物联合治疗的平均退热时间无显著差异。贫血、中度血小板减少和白细胞增多分别占50.7%、9.3%和14.7%。主要表现为发热(100%)、厌食(63.33%)、咳嗽(25.33%)、腹痛(24%)、腹泻(18.6%)。在苏拉特地区,头孢曲松是住院伤寒儿童常用的抗微生物药物。治疗方案与IAP指南不匹配,但与其他地区抗生素使用趋势相匹配。滥用药物是导致耐药的重要因素之一。
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引用次数: 0
Treatment of Psoriasis with the Help of Curcumin Hydrogel 姜黄素水凝胶治疗银屑病
Pub Date : 2023-05-13 DOI: 10.55544/jrasb.2.2.32
Y. Gupta, Neeraj Kumar, A. Shukla, Vishal Rai
Psoriasis is a chronic inflammatory skin disorder that affects millions of people worldwide. Current treatments for psoriasis include topical corticosteroids, immunomodulators, and phototherapy, but these treatments may have limited efficacy or cause side effects. Curcumin, a natural compound with anti-inflammatory and antioxidant properties, has been shown to have potential as an alternative treatment for psoriasis. However, the low solubility and bioavailability of curcumin limit its effectiveness when administered orally or topically. Curcumin hydrogel, a topical formulation of curcumin, has been developed to address these limitations. In this review, we summarize the current research on the use of curcumin hydrogel in the treatment of psoriasis. We discuss the pharmacological properties of curcumin, the formulation of curcumin hydrogel, and the preclinical and clinical studies investigating the efficacy and safety of curcumin hydrogel in psoriasis. Overall, the available evidence suggests that curcumin hydrogel may be a promising alternative treatment for psoriasis, with potential benefits in reducing inflammation, promoting wound healing, and improving overall quality of life for psoriasis patients. Further research is needed to fully elucidate the mechanism of action of curcumin hydrogel and to optimize its formulation and delivery for maximum efficacy.
牛皮癣是一种慢性炎症性皮肤病,影响着全世界数百万人。目前银屑病的治疗方法包括局部皮质类固醇、免疫调节剂和光疗,但这些治疗方法可能疗效有限或引起副作用。姜黄素是一种具有抗炎和抗氧化特性的天然化合物,已被证明有可能作为牛皮癣的替代治疗方法。然而,姜黄素的低溶解度和生物利用度限制了口服或局部给药的有效性。姜黄素水凝胶,姜黄素的局部配方,已开发,以解决这些限制。本文就姜黄素水凝胶在银屑病治疗中的应用研究现状进行综述。本文就姜黄素的药理作用、姜黄素水凝胶的制备方法、姜黄素水凝胶治疗银屑病的临床前和临床研究进行了综述。总的来说,现有证据表明姜黄素水凝胶可能是银屑病的一种有希望的替代治疗方法,具有减少炎症、促进伤口愈合和改善银屑病患者整体生活质量的潜在益处。为了充分阐明姜黄素水凝胶的作用机理,优化其配方和给药方式,使其发挥最大的功效,还需要进一步的研究。
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引用次数: 0
Assessment of Almond (Prunus dulcis L.) for Self-Compatibility and Stigma Receptivity Period Based on Fruit Set Index 基于坐果指数评价杏仁(Prunus dulcis L.)自亲和性和柱头接受期
Pub Date : 2023-05-13 DOI: 10.55544/jrasb.2.2.31
Yasin Kawsar, Hakimullah Abid, Naseer Mukhlis, Saifullah Mangal
Regarding to the self-compatibility test the 6 genotypes under the study show low self-fertilization and categorized in self-incompatible group, in evaluating the best time for hand pollination, the emasculated genotypes in the same day show significantly difference in responding to the hand pollination in  the days After emasculation which the highest fruit set percentage recorded in 3 days after emasculation and decreased in other days when considering the 0 day to 8  days after emasculation the study shows the importance and emphasis of choosing the overlapping varieties in an orchard and considering the self- incompatibility of genotypes and pollinator in reform and development of new almond orchard.
在自交亲和试验中,6个基因型自交受精率低,属于自交亲和组,在评价手传粉最佳时机时,在阉割后的第0天至第8天,阉割后3天坐果率最高,其余时间坐果率下降。研究表明,在果园中选择重叠品种,考虑基因型与传粉者的自交不亲和性对改革和发展的重要性和重点新的杏树园。
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引用次数: 0
Assessment of the Role of Pharmacists in Preventing Medication Errors in Hospital Settings 评价药师在预防医院用药差错中的作用
Pub Date : 2023-05-12 DOI: 10.55544/jrasb.2.2.30
Yash Gupta, Neeraj Kumar, Amrita Shukla, Vishal Rai
Medication errors can have serious consequences for patients in hospital settings. As medication experts, pharmacists play a critical role in preventing medication errors. This literature review examines the roles of pharmacists in preventing medication errors in hospital settings. The review identified several roles of pharmacists in preventing medication errors, including medication order review, medication reconciliation, providing drug information and education, and participation in interdisciplinary teams. The review also identified barriers to pharmacist involvement in preventing medication errors, such as limited access to patient information and limited communication with other healthcare professionals. Overall, the literature suggests that pharmacists can play a crucial role in preventing medication errors in hospital settings and that efforts should be made to overcome the barriers to their involvement.
用药错误会对住院患者造成严重后果。作为药物专家,药剂师在预防用药错误中起着至关重要的作用。本文献综述探讨了药剂师在预防医院用药错误中的作用。本综述确定了药师在预防用药差错方面的若干作用,包括医嘱审查、药物调解、提供药物信息和教育以及参与跨学科团队。该综述还确定了药剂师参与预防用药错误的障碍,例如获取患者信息的渠道有限,与其他医疗保健专业人员的沟通有限。总的来说,文献表明,药剂师可以发挥关键作用,在医院设置预防用药错误,应努力克服障碍,他们的参与。
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引用次数: 1
Growth and Instability in Area, Production and Productivity of Grape Crop in Afghanistan 阿富汗葡萄种植面积、产量和生产力的生长与不稳定
Pub Date : 2023-05-11 DOI: 10.55544/jrasb.2.2.25
Hamidullah Younisi, Zabihullah Farid, Khalid Joya
Grapes constitute a widely grown fruit in Afghanistan. Grapes can be grown just in anywhere but mostly in Kabul, Parwan, Kandahar, Zabul and Ghazni provinces. In Afghanistan there are three local varieties that offer the best commercial return for export: Shindokhani, Kishmishi and Taifi. New commercial varieties are also being introduced, such as Thompson Seedless and Red Globe, and are beginning to make inroads into foreign markets. The present study estimates the growth rate and instability of area, production, productivity of grape in top five provinces and Afghanistan as a whole during years 2011-12 to 2019-20. To analyse the growth rate and instability of area, production and productivity of grape, the statistical tools like Compound growth rate (CGR) and Coefficient of Variation (CV) were used. The result of the study showed that, the CGR for production in the Kandahar and Ghazni provinces were found positive and significant. While negative growth rate were found in Kabul, Parwan and Zabul provinces. The instability of production and area were very high in Kandahar province compare to the other selected provinces.
葡萄是阿富汗广泛种植的一种水果。葡萄可以在任何地方种植,但主要是在喀布尔、帕尔万、坎大哈、扎布尔和加兹尼省。在阿富汗,有三种当地品种为出口提供了最好的商业回报:Shindokhani、Kishmishi和Taifi。新的商业品种也被引进,如汤普森无籽和红地球,并开始进入国外市场。本研究估算了2011-12年至2019-20年阿富汗五大省和整个阿富汗的葡萄面积、产量和生产力的增长率和不稳定性。采用复合生长率(CGR)和变异系数(CV)等统计工具分析葡萄的生长速率和面积、产量和生产力的不稳定性。研究结果表明,坎大哈省和加兹尼省的生产CGR为正而显著。而在喀布尔、帕尔万和扎布尔省则出现了负增长。与其他选定的省份相比,坎大哈省的产量和面积的不稳定性非常高。
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引用次数: 0
A Review Article: Free Radical and Replacement Synthetic Antioxidant by Natural Antioxidant 综述:自由基与天然抗氧化剂替代合成抗氧化剂
Pub Date : 2023-05-11 DOI: 10.55544/jrasb.2.2.29
Roaa M. H. Shoker, Wasan Hamza Al-Shammery, S. AL-Aidy
Free radical may be responsible of several pathophysiology disease for threatening human life, and they are produced from endogenous and exogenous sources. Using the balanced amount  of nutritious diet lead to a good health, may be neutralizing or scavenging  free radicals by antioxidants compounds. daily diet have large number of vitamin A, E and C, carotenoids, polyphenols, etc. as natural antioxidants, the main bases of them are fruits, cereals, vegetables, and beverages. Enzymatic and non-enzymatic antioxidant substances are two different kinds that lessen the reactions of free radicals. In order to protect itself from reactive oxygen species, the human body uses an enzyme antioxidant. The two kinds of non-enzymatic antioxidants are natural antioxidants and synthetic antioxidants. The aim of this review is to knowledge a reasons which causes the free radical and balance them by natural antioxidant constituents, and replacement synthetic antioxidant by natural antioxidant, due to daily diet have large amounts from natural antioxidants, and natural antioxidants more effective than synthetic antioxidants, in additional they occurrence in nature and more inexpensive.
自由基可能是几种威胁人类生命的病理生理疾病的原因,它们有内源性和外源性来源。使用均衡的营养饮食导致身体健康,可能是中和或清除自由基的抗氧化剂化合物。日常饮食中含有大量的维生素A、E、C、类胡萝卜素、多酚等天然抗氧化剂,其主要来源是水果、谷物、蔬菜和饮料。酶促抗氧化物质和非酶促抗氧化物质是两种不同的减轻自由基反应的物质。为了保护自己免受活性氧的侵害,人体使用一种酶抗氧化剂。两种非酶促抗氧化剂是天然抗氧化剂和合成抗氧化剂。本文综述的目的是了解自由基产生的原因,并用天然抗氧化剂成分来平衡自由基,并用天然抗氧化剂来替代合成抗氧化剂,因为日常饮食中含有大量的天然抗氧化剂,而且天然抗氧化剂比合成抗氧化剂更有效,而且它们在自然界中存在且更便宜。
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引用次数: 1
Use and Phytochemical Activity of Celosia Argentea Linn 阿根廷芹的利用及植物化学活性研究
Pub Date : 2023-05-11 DOI: 10.55544/jrasb.2.2.24
R. Sangeetha, L. Kanchana, M. Suresh
Since ancient time in India. Celosia argentea linn. Is widely used in traditional medicine, to cure several disorders such as fever, diarrhea, mouth sores, itching wound, jaundice, gonorrhea and inflammation. Literaterature survey from books and journal of traditional Indian medicine revealed that celosia argentia linn. has a lot of medicinal properties. Leaves, stem and root have been reported for medicinal activity, the plant has pharmacologically been studied for various cativities like anti-cancer, hepatoprotection, anti-dibetes etc. However too many scientific studies have been carried out on this plant. For exploring these traditional uses. The present report is deals with traditional uses and pharmacological activity of celosia argentea linn. In the treatment of various diseases.
自古以来就存在于印度。阿根廷芹。在传统医学中被广泛使用,用于治疗发烧、腹泻、口腔溃疡、伤口瘙痒、黄疸、淋病和炎症等几种疾病。对印度传统医学书籍和杂志的文献调查显示,阿根廷芹属植物。有很多药用价值。叶、茎、根已被报道具有药用活性,药理研究表明其具有抗癌、保肝、抗糖尿病等多种活性。然而,对这种植物进行了太多的科学研究。探索这些传统的用途。本文介绍了青花的传统用途和药理活性。在治疗各种疾病。
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引用次数: 0
Certified Organic Production of Babycorn (Zea mays L.) based Legume Intercropping System as a Substitute Pathway for Sustainable Agriculture - A Review 以玉米(Zea mays L.)为基础的豆科作物间作体系有机认证生产——可持续农业替代途径综述
Pub Date : 2023-05-11 DOI: 10.55544/jrasb.2.2.28
A. Hekmat, Mohammad Daud Ahmadzai, Khanzad Gul Zazai, H. Ayoubi, Ahmad Javid Hekmat
Baby corn (Zea mays L.) refers to the whole, entirely edible cobs of immature corn harvested just before fertilization at 2-3 cm long silk emergence stage. The baby corn has a medium plant type and provides sweet, succulent and delicious green cobs within 65-75 days of sowing. Low quality yield of legumes and low yield of baby corn experienced due to continuous monoculture resulting from persistent soil depletion in the developing world have caused the need for a sustainable practice to improve quality and yield of aforementioned.
幼玉米(Zea mays L.)是指在2-3厘米长的出丝期,在受精前收获的完整的、完全可食用的未成熟玉米穗轴。小玉米有中等植株类型,在播种后65-75天内提供甜,多汁和美味的绿色穗轴。在发展中国家,由于持续的单一栽培造成持续的土壤枯竭,豆科作物和玉米幼体产量低,因此需要一种可持续的做法来提高上述作物的质量和产量。
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引用次数: 0
A Descriptive Look at the Factors Influencing the Geopolitics of Afghanistan 对影响阿富汗地缘政治因素的描述性分析
Pub Date : 2023-05-11 DOI: 10.55544/jrasb.2.2.26
Ziaulhaq Amiri, Sharifullah Habibyar
Geopolitics means the effect of the geographical location of the region on the policies of other governments. Afghanistan, as a landlocked country, is a strategic geographical area because of ​​its neighbors, and in principle, a country with a strategic position is inevitably part of the military strategy. Afghanistan also has this potential, so Afghanistan's geopolitical attractions have attracted the attention of superpowers from the past to the present. Understanding geopolitical codes is one of the factors that politicians of any government should try to identify to use the appropriate strategy to establish a strong diplomatic relationship with other countries.
地缘政治是指一个地区的地理位置对其他政府政策的影响。阿富汗作为一个内陆国家,由于周边邻国的关系,是一个战略地理区域,原则上,具有战略地位的国家必然是军事战略的一部分。阿富汗也有这种潜力,所以阿富汗的地缘政治吸引力从过去到现在一直吸引着超级大国的注意。理解地缘政治规则是任何政府的政治家都应该尝试确定的因素之一,以便使用适当的策略与其他国家建立牢固的外交关系。
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引用次数: 0
Comparing System of Wheat Intensification with Normal Practices Under Different Levels of Organic and Inorganic Fertilizer in Southeast Region of Afghanistan 阿富汗东南地区不同有机肥和无机肥水平下小麦集约化与常规做法体系比较
Pub Date : 2023-05-11 DOI: 10.55544/jrasb.2.2.27
A. Hekmat, Mohammad Daud Ahmadzai, Nazir khan Mohammadi
A field experiment was conducted to study the influence of NPK and FYM under normal practice and system of wheat intensification (SWI). The soil of the experimental area was sandy loam with pH (8.4); and available N (117.3 kg ha-1), medium in available P (13.85 kg ha-1) and high in available K (270 kg ha-1). Mazar 99 variety of wheat was chosen for the study. The experiment was laid out in split plot design with 24 treatments combination and three replications on a plot size of 1.5 x 3 m. Different cropping system (Broadcast method of sowing and system of wheat intensification) and different levels of NPK (50, 75 and 100%) were taken in main plot. Different levels of farm yard manure (0, 20, 40, 60, 80 and 100%) were assigned to sub plot in a split plot design. Application of 100 percent RDF under system of wheat intensification significantly influenced growth and growth attributes of wheat at different crop growth stages. Application of 100% RDF under system of wheat intensification (SWI) registered significantly higher plant height (23.4, 52.3, 77.7 and 82.9 cm), and dry matter accumulation (60, 257, 753 and 964 gram) at tillering, blooming, flowering and maturity stages and number of leaves (1130.0, 1722.3 and 2020.8) and number of tillers (187.9, 280.2 and 310) of wheat was also registered higher in same treatments at tillering, blooming and flowering stages of wheat respectively as compared to rest of the treatments. Different treatments of cropping system and different levels of RDF and FYM significantly influenced yield and yield attributes of wheat. Among the cropping system, M4 (100% RDF + SWI) registered significantly higher grain yield (3794.3 kg ha-1) and straw yield (6096.8 kg ha-1) as compared to rest of the treatments. Application of 100 percent farm yard manure recorded significant and maximum grain yield (3553.7 kg ha-1) as compared to rest of the treatments. While, the minimum grain yield (3060.8 kg ha-1) was recorded in S1 due to application of 0% FYM. Similarly, application of 100 percent farm yard manure recorded significantly higher straw yield (5935.5 kg ha-1) as compared to rest of the treatments. However, the lower grain yield (3060.8 kg ha-1) and straw yield (5373.4 kg ha-1) was observed in S1 due to application of zero percent farm yard manure. The interaction of 100% RDF + SWI with 100 % FYM showed highest grain yield (4060.0 kg ha-1) and straw yield (6450.0 kg ha-1) as compared to rest of the treatments. vOn the basis of economic analysis it is concluded that wheat cv. ‘Mazar 99’ sown under system of wheat intensification treated by 100% recommended dose of fertilizer (120-60-60 kg NPK/ha) accompanied with 20% N through FYM proved to be the most remunerative dose which will increase the grain yield of wheat by 33 percent as compared to M1S1 due to application of 100% RDF + 0% FYM under broadcast method of sowing. However, SWI will increase the net return by 36 percent as compared to broadcast method of sowing.
通过田间试验,研究了氮磷钾和氮肥在常规做法和小麦集约化制度下的影响。试验区土壤为砂壤土,pH值为8.4;速效氮(117.3 kg hm -1),速效磷中等(13.85 kg hm -1),速效钾高(270 kg hm -1)。小麦品种Mazar 99被选为研究对象。试验采用分割小区设计,24个处理组合,3个重复,小区面积为1.5 x 3 m。主田采用不同的种植制度(撒播法和小麦集约化制度)和不同水平的氮磷钾(50%、75%和100%)。采用分块设计,将不同水平的厩肥(0、20、40、60、80和100%)分配到分地块。在小麦集约化制度下施用100% RDF对小麦不同生育期的生长和生长性状有显著影响。在小麦强化体系(SWI)下,施用100% RDF显著提高了小麦的株高(23.4、52.3、77.7和82.9 cm),分蘖期、开花期、开花期和成熟期的干物质积累(60、257、753和964 g),分蘖期的叶片数(1130.0、1722.3和2020.8)和分蘖数(187.9、280.2和310)。与其他处理相比,小麦的开花和开花阶段。不同的种植制度和不同的RDF和FYM水平对小麦的产量和产量属性有显著影响。其中,M4 (100% RDF + SWI)的籽粒产量(3794.3 kg ha-1)和秸秆产量(6096.8 kg ha-1)显著高于其他处理。与其他处理相比,施用100%农场厩肥的籽粒产量显著且最高(3553.7 kg hm -1)。而施0%化肥的S1籽粒产量最低,为3060.8 kg hm -1。同样,与其他处理相比,施用100%农场厩肥的秸秆产量显著提高(5935.5 kg hm -1)。然而,由于施用0%农家肥,S1的谷物产量(3060.8 kg hm -1)和秸秆产量(5373.4 kg hm -1)较低。与其他处理相比,100% RDF + SWI与100% FYM互作的籽粒产量最高(4060.0 kg ha-1),秸秆产量最高(6450.0 kg ha-1)。在经济分析的基础上,得出了小麦产量与产量的关系。“Mazar 99”在小麦强化制度下,施用100%推荐用量(120-60-60公斤氮磷钾/公顷)和20%氮肥,经证实是最有利的施用剂量,与M1S1相比,由于施用100% RDF + 0%氮肥,在撒播法下播种,小麦产量将增加33%。然而,与播种法相比,SWI将使净收益增加36%。
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引用次数: 0
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International Journal For Research in Applied Sciences and Biotechnology
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