首页 > 最新文献

International Journal For Research in Applied Sciences and Biotechnology最新文献

英文 中文
An Analysis of How Artificial Intelligence is Used in the Field of Image Identification 人工智能在图像识别领域的应用分析
Pub Date : 2023-06-18 DOI: 10.55544/jrasb.2.3.14
Swarnima Mishra
Humans are adept at recognizing and detecting items that are right in front of them. People are extremely aware of how quickly and accurately the human visual system can carry out difficult tasks like object recognition and identification. But imagine a scenario in which they must retrieve a ring from a table that contains various-sized boxes and other objects. It will take a while to look for the key, and they will encounter several challenges. With the help of a computer program, one can quickly locate a ring, and with the help of a large quantity of data and an algorithm, one can quickly train datasets to accurately recognize and categorize a variety of items. Machine learning (ML) and artificial intelligence (AI) are current trends. The most well-known area of artificial intelligence is computer vision. Computer science and software that can detect and comprehend pictures are known as "computer vision." It also has object detection, imagine recognition, and more. Author of the paper has tried to describe the ideas behind contemporary object detection, object categorization, and object recognition.
人类善于识别和探测近在眼前的事物。人们非常清楚人类视觉系统在执行物体识别和识别等困难任务时是多么迅速和准确。但是想象一下这样一个场景:它们必须从包含各种大小的盒子和其他对象的表中检索一个环。寻找钥匙需要一段时间,他们会遇到一些挑战。在计算机程序的帮助下,人们可以快速定位一个戒指,在大量数据和算法的帮助下,人们可以快速训练数据集,以准确识别和分类各种物品。机器学习(ML)和人工智能(AI)是当前的趋势。人工智能最著名的领域是计算机视觉。能够检测和理解图片的计算机科学和软件被称为“计算机视觉”。它还具有对象检测、想象识别等功能。本文的作者试图描述当代目标检测、目标分类和目标识别背后的思想。
{"title":"An Analysis of How Artificial Intelligence is Used in the Field of Image Identification","authors":"Swarnima Mishra","doi":"10.55544/jrasb.2.3.14","DOIUrl":"https://doi.org/10.55544/jrasb.2.3.14","url":null,"abstract":"Humans are adept at recognizing and detecting items that are right in front of them. People are extremely aware of how quickly and accurately the human visual system can carry out difficult tasks like object recognition and identification. But imagine a scenario in which they must retrieve a ring from a table that contains various-sized boxes and other objects. It will take a while to look for the key, and they will encounter several challenges. With the help of a computer program, one can quickly locate a ring, and with the help of a large quantity of data and an algorithm, one can quickly train datasets to accurately recognize and categorize a variety of items. Machine learning (ML) and artificial intelligence (AI) are current trends. The most well-known area of artificial intelligence is computer vision. Computer science and software that can detect and comprehend pictures are known as \"computer vision.\" It also has object detection, imagine recognition, and more. Author of the paper has tried to describe the ideas behind contemporary object detection, object categorization, and object recognition.","PeriodicalId":13755,"journal":{"name":"International Journal For Research in Applied Sciences and Biotechnology","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85352360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methods Used for Solving Linear Equation Systems 求解线性方程组的方法
Pub Date : 2023-06-18 DOI: 10.55544/jrasb.2.3.15
Ghulam Omer Abdullah
The two variable equations of  whose degree of variables is
变量阶为的两变量方程
{"title":"Methods Used for Solving Linear Equation Systems","authors":"Ghulam Omer Abdullah","doi":"10.55544/jrasb.2.3.15","DOIUrl":"https://doi.org/10.55544/jrasb.2.3.15","url":null,"abstract":"The two variable equations of  whose degree of variables is","PeriodicalId":13755,"journal":{"name":"International Journal For Research in Applied Sciences and Biotechnology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79198523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategic Analysis of Agriculture Students’ Employability by SWOT Technic 运用SWOT技术对农业专业学生就业能力的战略分析
Pub Date : 2023-06-18 DOI: 10.55544/jrasb.2.3.13
Saeedullah Shinwari, Asadullah Sadat, Y. Mohammadi, Mohammad Sadiq Salihi
Without a doubt, having a high education will help you land a good career, but employers demand more from their workforce to benefit their business. The job market is tough these days. Employees that want to be competitive must possess a variety of employability skills. The primary goal of this study is to show the employability skills required of graduates in agriculture. The study site was at Iran's Bu-Ali-Sina University's Faculty of Agriculture in Hamadan province. There were 45 participants in the study; of these, 15 were lecturers, 15 were employers, and 15 were B.Sc. and M.Sc.-level students. Based on the result of the SWOT analysis strategy for agricultural students' employability are include “Prepare suitable work environment for students to gain work experience”, “before entering the job market, Holding entrepreneurial conferences and seminars to encourage entrepreneurs and explain government support for entrepreneurship”, “also giving government facility and support their new business”, “Increasing practical lessons than theoretical”, “and providing capital for starting a new business”, “To avoid a mental problem student should be chosen according to their interest field”, “and Increasing government funding to provide job opportunity for new graduates youths.”
毫无疑问,受过高等教育会帮助你找到一份好工作,但雇主对员工的要求更高,以有利于他们的业务。最近就业市场很不景气。想要有竞争力的员工必须拥有各种各样的就业技能。本研究的主要目的是显示农业毕业生所需的就业技能。该研究地点位于伊朗哈马丹省的Bu-Ali-Sina大学农学院。这项研究有45名参与者;其中15人是讲师,15人是雇主,15人是学士和硕士级别的学生。根据SWOT分析的结果,农业学生就业能力的策略包括“为学生准备合适的工作环境以获得工作经验”,“在进入就业市场之前,举办创业会议和研讨会以鼓励企业家并解释政府对创业的支持”,“也给予政府便利和支持他们的新业务”,“增加实践课程而不是理论”,“为创业提供资金”,“为了避免心理问题,应根据学生的兴趣领域选择学生”,“以及增加政府资助,为应届毕业生提供就业机会。”
{"title":"Strategic Analysis of Agriculture Students’ Employability by SWOT Technic","authors":"Saeedullah Shinwari, Asadullah Sadat, Y. Mohammadi, Mohammad Sadiq Salihi","doi":"10.55544/jrasb.2.3.13","DOIUrl":"https://doi.org/10.55544/jrasb.2.3.13","url":null,"abstract":"Without a doubt, having a high education will help you land a good career, but employers demand more from their workforce to benefit their business. The job market is tough these days. Employees that want to be competitive must possess a variety of employability skills. The primary goal of this study is to show the employability skills required of graduates in agriculture. The study site was at Iran's Bu-Ali-Sina University's Faculty of Agriculture in Hamadan province. There were 45 participants in the study; of these, 15 were lecturers, 15 were employers, and 15 were B.Sc. and M.Sc.-level students. Based on the result of the SWOT analysis strategy for agricultural students' employability are include “Prepare suitable work environment for students to gain work experience”, “before entering the job market, Holding entrepreneurial conferences and seminars to encourage entrepreneurs and explain government support for entrepreneurship”, “also giving government facility and support their new business”, “Increasing practical lessons than theoretical”, “and providing capital for starting a new business”, “To avoid a mental problem student should be chosen according to their interest field”, “and Increasing government funding to provide job opportunity for new graduates youths.”","PeriodicalId":13755,"journal":{"name":"International Journal For Research in Applied Sciences and Biotechnology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82985083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Socioeconomic Impacts of Development-Induced Displacement on Informal Settlement in Qalacha Khamdan, Kabul City, Afghanistan 发展导致的流离失所对阿富汗喀布尔市Qalacha Khamdan非正规住区的社会经济影响
Pub Date : 2023-06-17 DOI: 10.55544/jrasb.2.3.11
Mubarak Shah Hakimzai, Naeemullah Zaheer, Saber Shah Saberi
Development-induced displacement projects mainly involved locations with informal settlements, especially slum and squatter areas which left behind many socioeconomic impacts on displacement households. This forced displacement has caused breaking living patterns and social networks, destroying economic status, increasing infectious diseases, and other severe health problems. Many development projects, such as dam projects, airports, and road projects, have been implemented since 2001 in Afghanistan. The Kabul-Logar Road extension project, located on the southern side of Kabul city, has foreseen will destroy the existing socioeconomic status of Qalacha Khamdan's dwellers. Therefore, this paper examines the socioeconomic impacts of development-induced displacement on informal settlements in Qalacha Khamdan by the Kabul-Logar Road extension project. Data has been collected through site observation, questionnaires survey of heads of families affected, interviews with key informants, committees’ members, and some data from Cernea's model (IRR). The finding shows that the displaced population has lost social cohesion, social ties, close connectivity with brothers, relatives and neighbourhoods, businesses, valuable lands and well-designed homes. Finally, this study argues for more government and private sector involvement to manage the socioeconomic impacts of development-induced displacement after displacement.
发展导致的流离失所项目主要涉及非正规住区,特别是贫民窟和棚户区,这些地区对流离失所家庭造成了许多社会经济影响。这种被迫流离失所破坏了生活方式和社会网络,破坏了经济地位,增加了传染病和其他严重的健康问题。自2001年以来,阿富汗实施了许多发展项目,如大坝项目、机场和道路项目。位于喀布尔市南侧的喀布尔-洛加尔公路扩建项目预计将破坏Qalacha Khamdan居民现有的社会经济地位。因此,本文研究了喀布尔-洛加尔公路扩建项目对卡拉恰汗丹非正式定居点的发展导致的流离失所的社会经济影响。通过现场观察、对受影响家庭户主的问卷调查、对关键举报人、委员会成员的访谈以及Cernea模型(IRR)的一些数据来收集数据。调查结果表明,流离失所的人口失去了社会凝聚力、社会联系、与兄弟、亲戚和邻居、企业、宝贵的土地和精心设计的住房的密切联系。最后,本研究主张政府和私营部门应更多地参与管理发展导致的一次又一次流离失所的社会经济影响。
{"title":"Socioeconomic Impacts of Development-Induced Displacement on Informal Settlement in Qalacha Khamdan, Kabul City, Afghanistan","authors":"Mubarak Shah Hakimzai, Naeemullah Zaheer, Saber Shah Saberi","doi":"10.55544/jrasb.2.3.11","DOIUrl":"https://doi.org/10.55544/jrasb.2.3.11","url":null,"abstract":"Development-induced displacement projects mainly involved locations with informal settlements, especially slum and squatter areas which left behind many socioeconomic impacts on displacement households. This forced displacement has caused breaking living patterns and social networks, destroying economic status, increasing infectious diseases, and other severe health problems. Many development projects, such as dam projects, airports, and road projects, have been implemented since 2001 in Afghanistan. The Kabul-Logar Road extension project, located on the southern side of Kabul city, has foreseen will destroy the existing socioeconomic status of Qalacha Khamdan's dwellers. Therefore, this paper examines the socioeconomic impacts of development-induced displacement on informal settlements in Qalacha Khamdan by the Kabul-Logar Road extension project. Data has been collected through site observation, questionnaires survey of heads of families affected, interviews with key informants, committees’ members, and some data from Cernea's model (IRR). The finding shows that the displaced population has lost social cohesion, social ties, close connectivity with brothers, relatives and neighbourhoods, businesses, valuable lands and well-designed homes. Finally, this study argues for more government and private sector involvement to manage the socioeconomic impacts of development-induced displacement after displacement.","PeriodicalId":13755,"journal":{"name":"International Journal For Research in Applied Sciences and Biotechnology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78257027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Influential Factors on Students' Mathematical Interest in Schools 学校学生数学兴趣的影响因素探讨
Pub Date : 2023-06-17 DOI: 10.55544/jrasb.2.3.10
A. Abid, Ahmad Shah Noori
This research study aimed to identify and examine the factors that influence the level of interest among high school students in mathematics education. The study explored various factors, including student characteristics, teacher attributes, government involvement, infrastructure challenges, instructional strategies, class size, and concerns related to mathematics. A central high school in Khost was selected as the research site. A random sampling technique was employed to select participants from each class, ensuring representation based on age and gender. The findings revealed that seven factors significantly predicted high school students’ interest in mathematics education. Specifically, the teacher factor, student factor, instructional strategy, math concern, and infrastructure problem positively correlated with the level of interest. At the same time, the class size and government involvement exhibited a negative association. These findings highlight the significance of these factors in shaping students' engagement with mathematics. Based on the results, it is recommended that the government implement regular professional development programs for mathematics teachers to enhance their instructional strategies, enabling them to nurture students' interest in mathematics education effectively.
本研究旨在探讨影响高中生数学教育兴趣水平的因素。该研究探讨了各种因素,包括学生特征、教师属性、政府参与、基础设施挑战、教学策略、班级规模以及与数学相关的问题。霍斯特的一所中心高中被选为研究地点。采用随机抽样技术从每个班级中选择参与者,以确保年龄和性别的代表性。结果发现,七个因素显著预测高中生对数学教育的兴趣。具体而言,教师因素、学生因素、教学策略、数学关注和基础设施问题与兴趣水平呈正相关。同时,班级规模与政府参与呈负相关。这些发现强调了这些因素在塑造学生参与数学的重要性。根据研究结果,建议政府针对数学教师实施定期的专业发展计划,以改善其教学策略,使其能够有效地培养学生对数学教育的兴趣。
{"title":"Exploring the Influential Factors on Students' Mathematical Interest in Schools","authors":"A. Abid, Ahmad Shah Noori","doi":"10.55544/jrasb.2.3.10","DOIUrl":"https://doi.org/10.55544/jrasb.2.3.10","url":null,"abstract":"This research study aimed to identify and examine the factors that influence the level of interest among high school students in mathematics education. The study explored various factors, including student characteristics, teacher attributes, government involvement, infrastructure challenges, instructional strategies, class size, and concerns related to mathematics. A central high school in Khost was selected as the research site. A random sampling technique was employed to select participants from each class, ensuring representation based on age and gender. The findings revealed that seven factors significantly predicted high school students’ interest in mathematics education. Specifically, the teacher factor, student factor, instructional strategy, math concern, and infrastructure problem positively correlated with the level of interest. At the same time, the class size and government involvement exhibited a negative association. These findings highlight the significance of these factors in shaping students' engagement with mathematics. Based on the results, it is recommended that the government implement regular professional development programs for mathematics teachers to enhance their instructional strategies, enabling them to nurture students' interest in mathematics education effectively.","PeriodicalId":13755,"journal":{"name":"International Journal For Research in Applied Sciences and Biotechnology","volume":"339 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77655134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combine Therapy of Gallic Acid and Allicin in Management of Diabetes 没食子酸与大蒜素联合治疗糖尿病
Pub Date : 2023-06-17 DOI: 10.55544/jrasb.2.3.12
R. Kumar, Prachi Sood, Dr. Vinod Rana, A. Prajapati
Type 2 diabetes, also known (DM) is a metabolic disorder with a high mortality and disability incidence. The development and activation of oxidative stress (OS) are crucial to the pathogenic development of DM. Pathophysiological evidence suggests that OS contributes to the onset and progression of DM through its association with hyperglycemia, resistance to insulin, and inflammation. It's worth noting that more and more studies are investigating the benefits of natural antioxidants for managing DM. Many different types of culinary and herbal plants contain the antioxidant and anti-inflammatory compounds gallic acid (GA) and allicin, respectively. The synthesis of advanced glycation end products (AGEs) is inhibited, fat is stored less, blood sugar and weight are improved, and the body produces fewer AGEs, according to the study's authors. Inhibition of RAGEs and prevention of AGE activity following treatment with GA and allicin resulted in reduced oxidative stress and enhanced insulin secretion. The goals of this article are to (1) provide evidence that GA and allicin may be effective antihyperglycemic treatments for DM and its complications and (2) provide a comprehensive review of the current state of knowledge regarding studies examining the role of oleic acid in this disease.
2型糖尿病,也被称为(DM)是一种高死亡率和致残率的代谢性疾病。氧化应激(OS)的发生和激活对糖尿病的发病至关重要。病理生理学证据表明,氧化应激与高血糖、胰岛素抵抗和炎症有关,有助于糖尿病的发生和进展。值得注意的是,越来越多的研究正在调查天然抗氧化剂对管理糖尿病的好处。许多不同类型的烹饪和草药植物分别含有抗氧化剂和抗炎化合物没食子酸(GA)和大蒜素。该研究的作者表示,晚期糖基化终产物(AGEs)的合成受到抑制,脂肪储存减少,血糖和体重得到改善,身体产生的AGEs减少。GA和大蒜素对RAGEs的抑制和AGE活性的预防导致氧化应激的减少和胰岛素分泌的增加。本文的目的是:(1)提供证据,证明GA和大蒜素可能是糖尿病及其并发症的有效降糖治疗方法;(2)对油酸在糖尿病中的作用的研究现状进行全面回顾。
{"title":"Combine Therapy of Gallic Acid and Allicin in Management of Diabetes","authors":"R. Kumar, Prachi Sood, Dr. Vinod Rana, A. Prajapati","doi":"10.55544/jrasb.2.3.12","DOIUrl":"https://doi.org/10.55544/jrasb.2.3.12","url":null,"abstract":"Type 2 diabetes, also known (DM) is a metabolic disorder with a high mortality and disability incidence. The development and activation of oxidative stress (OS) are crucial to the pathogenic development of DM. Pathophysiological evidence suggests that OS contributes to the onset and progression of DM through its association with hyperglycemia, resistance to insulin, and inflammation. It's worth noting that more and more studies are investigating the benefits of natural antioxidants for managing DM. Many different types of culinary and herbal plants contain the antioxidant and anti-inflammatory compounds gallic acid (GA) and allicin, respectively. The synthesis of advanced glycation end products (AGEs) is inhibited, fat is stored less, blood sugar and weight are improved, and the body produces fewer AGEs, according to the study's authors. Inhibition of RAGEs and prevention of AGE activity following treatment with GA and allicin resulted in reduced oxidative stress and enhanced insulin secretion. The goals of this article are to (1) provide evidence that GA and allicin may be effective antihyperglycemic treatments for DM and its complications and (2) provide a comprehensive review of the current state of knowledge regarding studies examining the role of oleic acid in this disease.","PeriodicalId":13755,"journal":{"name":"International Journal For Research in Applied Sciences and Biotechnology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84819668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Recent Approaches of Matrix Release Tablet in NDDS System 矩阵缓释片在NDDS系统中的研究进展
Pub Date : 2023-06-14 DOI: 10.55544/jrasb.2.3.9
Sashank Shekhar, Alok Kumar, Vinod Rana, R. Kumar, Chavi Mittal, Kanchan Tariyal
The purpose of this analysis is to categorize matrix tablets according to the kind of polymer they are made of as well as the rate at which they release their contents. When it came to medicinal applications, the matrix system was the very first oral extended release platform ever developed. The utilization of matrix tablets enables the modification of drug release characteristics. They are highly favored for this kind of treatment because of the benefits they give for the patient in terms of better adherence to the treatment, more stable medication levels, decreased dose and bad effects, and a bigger safety margin for highly potent medications. Because of their versatility in delivering a desired drug release profile, cheap cost, and general regulatory acceptability, hydrophilic polymer matrix systems are frequently used in oral controlled drug delivery dosage forms. Because of the rapid diffusion of the dissolved medication via the hydrophilic gel network, the use of hydrophilic matrix alone for delayed drug release is not possible for medicines that are very water soluble. It is now generally accepted that the formulation of such drugs requires the use of matrix systems that incorporate hydrophobic polymers. It would appear that the most successful strategy would be to create a formulation for oral controlled release by employing matrix tablets.
本分析的目的是根据它们所制成的聚合物的种类以及它们释放其内容物的速度对基质片进行分类。在医学应用方面,基质系统是有史以来开发的第一个口服缓释平台。利用基质片可以改变药物的释放特性。他们非常喜欢这种治疗因为他们给病人带来的好处是更好地坚持治疗,更稳定的药物水平,减少剂量和不良影响,以及更大的安全边际对于强效药物。由于亲水性聚合物基质系统在提供所需药物释放方面的通用性,成本低廉,以及一般的监管可接受性,因此经常用于口服控制药物递送剂型。由于溶解的药物通过亲水性凝胶网络迅速扩散,对于水溶性很强的药物,仅使用亲水性基质来延迟药物释放是不可能的。现在人们普遍认为,这类药物的配方需要使用含有疏水聚合物的基质系统。看来,最成功的策略是利用基质片剂制造一种口服控释制剂。
{"title":"Recent Approaches of Matrix Release Tablet in NDDS System","authors":"Sashank Shekhar, Alok Kumar, Vinod Rana, R. Kumar, Chavi Mittal, Kanchan Tariyal","doi":"10.55544/jrasb.2.3.9","DOIUrl":"https://doi.org/10.55544/jrasb.2.3.9","url":null,"abstract":"The purpose of this analysis is to categorize matrix tablets according to the kind of polymer they are made of as well as the rate at which they release their contents. When it came to medicinal applications, the matrix system was the very first oral extended release platform ever developed. The utilization of matrix tablets enables the modification of drug release characteristics. They are highly favored for this kind of treatment because of the benefits they give for the patient in terms of better adherence to the treatment, more stable medication levels, decreased dose and bad effects, and a bigger safety margin for highly potent medications. Because of their versatility in delivering a desired drug release profile, cheap cost, and general regulatory acceptability, hydrophilic polymer matrix systems are frequently used in oral controlled drug delivery dosage forms. Because of the rapid diffusion of the dissolved medication via the hydrophilic gel network, the use of hydrophilic matrix alone for delayed drug release is not possible for medicines that are very water soluble. It is now generally accepted that the formulation of such drugs requires the use of matrix systems that incorporate hydrophobic polymers. It would appear that the most successful strategy would be to create a formulation for oral controlled release by employing matrix tablets.","PeriodicalId":13755,"journal":{"name":"International Journal For Research in Applied Sciences and Biotechnology","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82343259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
A Review on Fluconazole 氟康唑研究进展
Pub Date : 2023-06-14 DOI: 10.55544/jrasb.2.3.6
Sharanpreet Kaur, N. Kaur, Gursimran Kaur, Prabhat Kumar
The improvement of a significant dissolution manner for drug merchandise with restrained water solubility has been a project to the pharmaceutical industry. fluconazole (BCS Class 1 drug) is an anti-fungal drug. There isn't any reputable dissolution medium to be had withinside the literature. In the prevailing study, parameters inclusive of solubility, medium pH, surfactant type, dissolution behaviour of formulations, impact of sink situations, stability, and discriminatory impact of dissolution checking out had been studied for the choice of a right dissolution medium. Results of solubility facts found out that solubility elevated with a growth in pH. The drug and advertised formulations had been strong withinside the dissolution media used. An agitation velocity of fifty rpm confirmed a greater discriminating drug launch profile than seventy-five rpm. The discriminating dissolution technique for fluconazole components is paddle at 50 rpm, 900 mL pH 6.8 phosphate buffer, more than 80% of the label quantity is launched over 60 minutes.
改善具有限制水溶性的药品的重要溶出方式一直是制药工业的一个项目。氟康唑是一种抗真菌药物。在文献中没有任何可靠的溶解介质。在目前的研究中,研究了溶解度、介质pH、表面活性剂类型、配方的溶解行为、沉降情况的影响、稳定性和溶解检查的歧视性影响等参数,以选择合适的溶解介质。溶解度事实的结果发现,溶解度随着ph值的增长而提高。药物和广告配方在使用的溶解介质中很强。与75转/分相比,50转/分的搅拌速度证实了更强的药物发射特征。氟康唑成分的鉴别溶出技术是桨速50 rpm, 900 mL pH 6.8磷酸盐缓冲液,超过80%的标签量在60分钟内启动。
{"title":"A Review on Fluconazole","authors":"Sharanpreet Kaur, N. Kaur, Gursimran Kaur, Prabhat Kumar","doi":"10.55544/jrasb.2.3.6","DOIUrl":"https://doi.org/10.55544/jrasb.2.3.6","url":null,"abstract":"The improvement of a significant dissolution manner for drug merchandise with restrained water solubility has been a project to the pharmaceutical industry. fluconazole (BCS Class 1 drug) is an anti-fungal drug. There isn't any reputable dissolution medium to be had withinside the literature. In the prevailing study, parameters inclusive of solubility, medium pH, surfactant type, dissolution behaviour of formulations, impact of sink situations, stability, and discriminatory impact of dissolution checking out had been studied for the choice of a right dissolution medium. Results of solubility facts found out that solubility elevated with a growth in pH. The drug and advertised formulations had been strong withinside the dissolution media used. An agitation velocity of fifty rpm confirmed a greater discriminating drug launch profile than seventy-five rpm. The discriminating dissolution technique for fluconazole components is paddle at 50 rpm, 900 mL pH 6.8 phosphate buffer, more than 80% of the label quantity is launched over 60 minutes.","PeriodicalId":13755,"journal":{"name":"International Journal For Research in Applied Sciences and Biotechnology","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90515534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Randomized Phase III Trial Comparing Epirubicin/ Doxorubicin Plus Docetaxel and Epirubicin/ Doxorubicin Plus Paclitaxel as First Line Treatment in Women with Advanced Breast Cancer 比较表柔比星/阿霉素+多西他赛和表柔比星/阿霉素+紫杉醇作为晚期乳腺癌妇女一线治疗的随机III期试验
Pub Date : 2023-06-12 DOI: 10.55544/jrasb.2.3.8
R. Guru Nirmal Raj, Aditya Kumar, Prachi Sood, Roshan Kumar, Vinod Rana
This study aimed to examine the efficacy of docetaxel plus epirubicin against docetaxel plus capecitabine as first-line therapy for women with advanced breast cancer (ABC). Patients with ABC who had not been treated in the past were split into two groups: those who received docetaxel and epirubicin (DE) on day 1 and those who received docetaxel and capecitabine (DC) on day 1 and twice daily on days 1-14 of each 21-day cycle. Prior neoadjuvant treatment with anthracyclines was permitted if it had been finished more than a year prior to enrolment. The study's major aim was to evaluate the difference in time to disease progression (TTP). Median TTP for DE was 10.6 months and for DC it was 11.0 months (P = 0.7), with each arm treating 170 women. Using the RECIST criterion, we found that the rates of complete responses were higher in DC (61%) than in DE (11%), and that the rates of partial responses were lower in DC (40%) than in DE (45%) (P = 0.8). Grade 3-4 neutropenia was more common with DE than DC (57% vs. 46%, P = 0.07), as were febrile neutropenia (11% vs. 8%, P = 0.4), hand-foot syndrome (0% vs. 4%, P = 0.02), grade 2-3 anemia (20% vs. 7%, P = 0.001), and asthenia (12% vs. 6%, P = 0.09).
本研究旨在探讨多西他赛联合表柔比星与多西他赛联合卡培他滨作为一线治疗晚期乳腺癌(ABC)的疗效。过去未接受过治疗的ABC患者分为两组:第1天接受多西他赛和表柔比星(DE)治疗的患者和第1天接受多西他赛和卡培他滨(DC)治疗的患者,每21天周期的第1-14天每天两次。如果在入组前一年以上完成蒽环类药物的新辅助治疗,则允许使用蒽环类药物。该研究的主要目的是评估疾病进展时间(TTP)的差异。DE的中位TTP为10.6个月,DC的中位TTP为11.0个月(P = 0.7),每组治疗170名妇女。使用RECIST标准,我们发现DC患者的完全缓解率(61%)高于DE患者(11%),DC患者的部分缓解率(40%)低于DE患者(45%)(P = 0.8)。3-4级中性粒细胞减少症在DE患者中比DC患者更常见(57%比46%,P = 0.07),发热性中性粒细胞减少症(11%比8%,P = 0.4)、手足综合征(0%比4%,P = 0.02)、2-3级贫血(20%比7%,P = 0.001)和虚弱(12%比6%,P = 0.09)也是如此。
{"title":"Randomized Phase III Trial Comparing Epirubicin/ Doxorubicin Plus Docetaxel and Epirubicin/ Doxorubicin Plus Paclitaxel as First Line Treatment in Women with Advanced Breast Cancer","authors":"R. Guru Nirmal Raj, Aditya Kumar, Prachi Sood, Roshan Kumar, Vinod Rana","doi":"10.55544/jrasb.2.3.8","DOIUrl":"https://doi.org/10.55544/jrasb.2.3.8","url":null,"abstract":"This study aimed to examine the efficacy of docetaxel plus epirubicin against docetaxel plus capecitabine as first-line therapy for women with advanced breast cancer (ABC). Patients with ABC who had not been treated in the past were split into two groups: those who received docetaxel and epirubicin (DE) on day 1 and those who received docetaxel and capecitabine (DC) on day 1 and twice daily on days 1-14 of each 21-day cycle. Prior neoadjuvant treatment with anthracyclines was permitted if it had been finished more than a year prior to enrolment. The study's major aim was to evaluate the difference in time to disease progression (TTP). Median TTP for DE was 10.6 months and for DC it was 11.0 months (P = 0.7), with each arm treating 170 women. Using the RECIST criterion, we found that the rates of complete responses were higher in DC (61%) than in DE (11%), and that the rates of partial responses were lower in DC (40%) than in DE (45%) (P = 0.8). Grade 3-4 neutropenia was more common with DE than DC (57% vs. 46%, P = 0.07), as were febrile neutropenia (11% vs. 8%, P = 0.4), hand-foot syndrome (0% vs. 4%, P = 0.02), grade 2-3 anemia (20% vs. 7%, P = 0.001), and asthenia (12% vs. 6%, P = 0.09).","PeriodicalId":13755,"journal":{"name":"International Journal For Research in Applied Sciences and Biotechnology","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79561506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Evaluation of the Level of Histamine 1 and 2 Receptors with Some Biochemical Variables in Patients with Hepatitis C Virus Infection 丙型肝炎病毒感染患者组胺1、2受体水平及生化指标的评价
Pub Date : 2023-06-12 DOI: 10.55544/jrasb.2.3.7
Moamen Mohamed Shaker, Firas Shawqi Algburi
The current study was carried out at Ibn - Sina Hospital in Nineveh Governorate, where the relationship between histamine receptors1&2, liver enzyme functions, Albumin, and Alkaline phosphate was studied in patients with hepatitis C virus type. Samples were taken from patients diagnosed with hepatitis C, 60 of whom were compared with 30 controls. Take 5ml of blood, separate it with a centrifuge, and test the serum. The sample size was equal for Men and Women, and the age range was 18 to 78 years. ALT (GPT), Albumin, Alkaline phosphates, and histamine-2 receptor levels were statistically significant, while AST (GOT) and histamine-1 receptor levels were not statistically significant.
目前的研究是在尼尼微省Ibn - Sina医院进行的,研究了丙型肝炎病毒患者组胺受体1和2、肝酶功能、白蛋白和碱性磷酸盐之间的关系。样本取自诊断为丙型肝炎的患者,其中60人与30人对照。取5ml血液,用离心机分离,检测血清。男性和女性的样本量相等,年龄范围为18至78岁。ALT (GPT)、白蛋白(Albumin)、碱性磷酸盐(Alkaline phosphate)、组胺-2受体水平差异均有统计学意义,AST (GOT)、组胺-1受体水平差异无统计学意义。
{"title":"Evaluation of the Level of Histamine 1 and 2 Receptors with Some Biochemical Variables in Patients with Hepatitis C Virus Infection","authors":"Moamen Mohamed Shaker, Firas Shawqi Algburi","doi":"10.55544/jrasb.2.3.7","DOIUrl":"https://doi.org/10.55544/jrasb.2.3.7","url":null,"abstract":"The current study was carried out at Ibn - Sina Hospital in Nineveh Governorate, where the relationship between histamine receptors1&2, liver enzyme functions, Albumin, and Alkaline phosphate was studied in patients with hepatitis C virus type. Samples were taken from patients diagnosed with hepatitis C, 60 of whom were compared with 30 controls. Take 5ml of blood, separate it with a centrifuge, and test the serum. The sample size was equal for Men and Women, and the age range was 18 to 78 years. ALT (GPT), Albumin, Alkaline phosphates, and histamine-2 receptor levels were statistically significant, while AST (GOT) and histamine-1 receptor levels were not statistically significant.","PeriodicalId":13755,"journal":{"name":"International Journal For Research in Applied Sciences and Biotechnology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91544264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal For Research in Applied Sciences and Biotechnology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1